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Conserved domains on  [gi|491000781|ref|WP_004862503|]
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MULTISPECIES: sensor histidine kinase [Raoultella]

Protein Classification

sensor histidine kinase( domain architecture ID 11485193)

two-component system sensor histidine kinase with a PAS sensor and/or ligand binding domain functions as a protein kinase that phosphorylates a target protein in response to various signals, similar to Escherichia coli sensor histidine kinase DcuS and Bacillus subtilis sensor histidine kinase MalK

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PRK11086 PRK11086
sensory histidine kinase DcuS; Provisional
 6-539 0e+00

sensory histidine kinase DcuS; Provisional


:

Pssm-ID: 236839 [Multi-domain]  Cd Length: 542  Bit Score: 847.27  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491000781   6 ESIPPARKRLMSMKLSTAVTLMISSVIGSVLLLVYALWFIQISDTTRDGVKDTALAVARTFSDMPEVKQALTLPPQSGLI 85
Cdd:PRK11086   2 HSLPYMKKRKRPMKLSTTVTLMVSAVVFSVLLVVHLLYFSQISRMTRDGLAEKALAIARTVADSPIVIQGLQGKPDESGI 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491000781  86 QPLALAITRRNDLLYAVVTDMHGVRYSHPNARLIGKQFIGEDIQPAFNGKENVAVNHGVLAPALRVFTPVFNDQQQQIGV 165
Cdd:PRK11086  82 QTYAEAVRKRNDLLFIVVTDMQGIRYSHPNPQKIGKHFIGGDELPALKGKENVSINRGTLGQALRVFTPVYDENGKQIGV 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491000781 166 VVVGISLSKVDEQIAKGRWDVLLTVLFSALVCGIGTWSLVRGLKRVLLGLEPQEISTQFQQRQAMLHSLKEGVVAVDVEG 245
Cdd:PRK11086 162 VAVGISLSEVTEQINESRWSIYWSILFGALVGLIGTVILVRVLKRILFGLEPYEISTLFEQRQAMLQSIKEGVIAVDDRG 241

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491000781 246 RVTLINPAASEIL--LSG-----PGKEIAHTPLLADLQEVLQTGEPIYDRELGCNGFLLISNTVPVRSQNAIVGAISTFR 318
Cdd:PRK11086 242 EVTLINDEAKRLFnyKKGleddpLGTDVESWMPVSRLKEVLRTGTPRRDEEININGRLLLTNTVPVRVNGEIIGAIATFR 321

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491000781 319 DKTEVSQLLQRLDGMVNYVDALRTTSHEFMNKLHVILGLLNMKSYDKLEEYVLQTAHTYQADIGEIQHRIKSPVVAGFLI 398
Cdd:PRK11086 322 DKTEVRQLAQRLDGMVNYADALRAQSHEFMNKLHVILGLLHLKSYDQLEDYILKTANNYQEEIGSLLGKIKSPVIAGFLL 401

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491000781 399 GKIQRAKERGFTLNLAEESLVPDCPNEKQVTVLVTVLGNLIENALDAMSGQSEGEVGLLLHYQNGWLSGEVSDDGPGIPP 478
Cdd:PRK11086 402 GKISRARELGITLIISEDSQLPDSGDEDQVHELITILGNLIENALEAVGGEEGGEISVSLHYRNGWLHCEVSDDGPGIAP 481

                        490       500       510       520       530       540
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 491000781 479 ANIDAIFNKGFSTKGENRGVGLFLASQQLRELGGTLAVESEPGVFTQFFVHLPWDSKRKRA 539
Cdd:PRK11086 482 DEIDAIFDKGYSTKGSNRGVGLYLVKQSVENLGGSIAVESEPGVGTQFFVQIPWDGERSNR 542
 
Name Accession Description Interval E-value
PRK11086 PRK11086
sensory histidine kinase DcuS; Provisional
 6-539 0e+00

sensory histidine kinase DcuS; Provisional


Pssm-ID: 236839 [Multi-domain]  Cd Length: 542  Bit Score: 847.27  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491000781   6 ESIPPARKRLMSMKLSTAVTLMISSVIGSVLLLVYALWFIQISDTTRDGVKDTALAVARTFSDMPEVKQALTLPPQSGLI 85
Cdd:PRK11086   2 HSLPYMKKRKRPMKLSTTVTLMVSAVVFSVLLVVHLLYFSQISRMTRDGLAEKALAIARTVADSPIVIQGLQGKPDESGI 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491000781  86 QPLALAITRRNDLLYAVVTDMHGVRYSHPNARLIGKQFIGEDIQPAFNGKENVAVNHGVLAPALRVFTPVFNDQQQQIGV 165
Cdd:PRK11086  82 QTYAEAVRKRNDLLFIVVTDMQGIRYSHPNPQKIGKHFIGGDELPALKGKENVSINRGTLGQALRVFTPVYDENGKQIGV 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491000781 166 VVVGISLSKVDEQIAKGRWDVLLTVLFSALVCGIGTWSLVRGLKRVLLGLEPQEISTQFQQRQAMLHSLKEGVVAVDVEG 245
Cdd:PRK11086 162 VAVGISLSEVTEQINESRWSIYWSILFGALVGLIGTVILVRVLKRILFGLEPYEISTLFEQRQAMLQSIKEGVIAVDDRG 241

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491000781 246 RVTLINPAASEIL--LSG-----PGKEIAHTPLLADLQEVLQTGEPIYDRELGCNGFLLISNTVPVRSQNAIVGAISTFR 318
Cdd:PRK11086 242 EVTLINDEAKRLFnyKKGleddpLGTDVESWMPVSRLKEVLRTGTPRRDEEININGRLLLTNTVPVRVNGEIIGAIATFR 321

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491000781 319 DKTEVSQLLQRLDGMVNYVDALRTTSHEFMNKLHVILGLLNMKSYDKLEEYVLQTAHTYQADIGEIQHRIKSPVVAGFLI 398
Cdd:PRK11086 322 DKTEVRQLAQRLDGMVNYADALRAQSHEFMNKLHVILGLLHLKSYDQLEDYILKTANNYQEEIGSLLGKIKSPVIAGFLL 401

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491000781 399 GKIQRAKERGFTLNLAEESLVPDCPNEKQVTVLVTVLGNLIENALDAMSGQSEGEVGLLLHYQNGWLSGEVSDDGPGIPP 478
Cdd:PRK11086 402 GKISRARELGITLIISEDSQLPDSGDEDQVHELITILGNLIENALEAVGGEEGGEISVSLHYRNGWLHCEVSDDGPGIAP 481

                        490       500       510       520       530       540
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 491000781 479 ANIDAIFNKGFSTKGENRGVGLFLASQQLRELGGTLAVESEPGVFTQFFVHLPWDSKRKRA 539
Cdd:PRK11086 482 DEIDAIFDKGYSTKGSNRGVGLYLVKQSVENLGGSIAVESEPGVGTQFFVQIPWDGERSNR 542
CitA COG3290
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction ...
 184-535 4.05e-112

Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction mechanisms];


Pssm-ID: 442519 [Multi-domain]  Cd Length: 389  Bit Score: 338.36  E-value: 4.05e-112
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491000781 184 WDVLLTVLFSALVCGIGTWSLVRGLKRVLLGLEpQEISTQFQQRQAMLHSLKEGVVAVDVEGRVTLINPAASEILlsgpG 263
Cdd:COG3290   44 LFVIILLLLLLILLLILLLLLLLLLAALLLKLL-EEIARLVEEREAVLESIREGVIAVDRDGRITLINDAARRLL----G 118

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491000781 264 KEIAHTPLLADLQEVLQTGEpiYDRELGCNGFLLISNTVPVRSQNAIVGAISTFRDKTEVSQLLQRLDGMVNYVDALRTT 343
Cdd:COG3290  119 LDAIGRPIDEVLAEVLETGE--RDEEILLNGRVLVVNRVPIRDDGRVVGAVATFRDRTELERLEEELEGVKELAEALRAQ 196

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491000781 344 SHEFMNKLHVILGLLNMKSYDKLEEYVLQTAHTYQADIGEIQHRIKSPVVAGFLIGKIQRAKERGFTLNLAEESLVPDCP 423
Cdd:COG3290  197 RHDFRNHLHTISGLLQLGEYDEALEYIDEISEELQELIDSLLSRIGNPVLAALLLGKAARARERGIDLTIDIDSDLPDLP 276

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491000781 424 neKQVTVLVTVLGNLIENALDAMSGQ--SEGEVGLLLHYQNGWLSGEVSDDGPGIPPANIDAIFNKGFSTK-GENRGVGL 500
Cdd:COG3290  277 --LSDTDLVTILGNLLDNAIEAVEKLpeEERRVELSIRDDGDELVIEVEDSGPGIPEELLEKIFERGFSTKlGEGRGLGL 354

                        330       340       350
                 ....*....|....*....|....*....|....*
gi 491000781 501 FLASQQLRELGGTLAVESEPGVFTQFFVHLPWDSK 535
Cdd:COG3290  355 ALVKQIVEKYGGTIEVESEEGEGTVFTVRLPKEGE 389
HATPase_DpiB-CitA-like cd16915
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 431-531 5.52e-33

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 DpiB, DcuS, and Bacillus subtilis CitS, DctS, and YufL; This family includes histidine kinase-like ATPase domains of Escherichia coli K-12 DpiB and DcuS, and Bacillus subtilis CitS, DctS and MalK histidine kinases (HKs) all of which are two component transduction systems (TCSs). E. coli K-12 DpiB (also known as CitA) is the histidine kinase (HK) of DpiA-DpiB, a two-component signal transduction system (TCS) required for the expression of citrate-specific fermentation genes and genes involved in plasmid inheritance. E. coli K-12 DcuS (also known as YjdH) is the HK of DcuS-DcuR, a TCS that in the presence of the extracellular C4-dicarboxlates, activates the expression of the genes of anaerobic fumarate respiration and of aerobic C4-dicarboxylate uptake. CitS is the HK of Bacillus subtilis CitS-CitT, a TCS which regulates expression of CitM, the Mg-citrate transporter. Bacillus subtilis DctS forms a tripartite sensor unit (DctS/DctA/DctB) for sensing C4 dicarboxylates. Bacillus subtilis MalK (also known as YfuL) is the HK of MalK-MalR (YufL-YufM) a TCS which regulates the expression of the malate transporters MaeN (YufR) and YflS, and is essential for utilization of malate in minimal medium. Proteins having this DpiB-CitA-like HATPase domain generally have sensor domains such as Cache and PAS, and a histidine kinase A (HisKA)-like SpoOB-type, alpha-helical domain.


Pssm-ID: 340392 [Multi-domain]  Cd Length: 104  Bit Score: 121.24  E-value: 5.52e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491000781 431 LVTVLGNLIENALDAM--SGQSEGEVGLLLHYQNGWLSGEVSDDGPGIPPANIDAIFNKGFSTKGE-NRGVGLFLASQQL 507
Cdd:cd16915    1 LITIVGNLIDNALDALaaTGAPNKQVEVFLRDEGDDLVIEVRDTGPGIAPELRDKVFERGVSTKGQgERGIGLALVRQSV 80

                         90       100
                 ....*....|....*....|....
gi 491000781 508 RELGGTLAVESEPGVFTQFFVHLP 531
Cdd:cd16915   81 ERLGGSITVESEPGGGTTFSIRIP 104
HATPase_c smart00387
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
 431-531 5.74e-21

Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.


Pssm-ID: 214643 [Multi-domain]  Cd Length: 111  Bit Score: 88.09  E-value: 5.74e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491000781   431 LVTVLGNLIENALDAMsgQSEGEVGLLLHYQNGWLSGEVSDDGPGIPPANIDAIFNKGFSTKGENR-----GVGLFLASQ 505
Cdd:smart00387   6 LRQVLSNLLDNAIKYT--PEGGRITVTLERDGDHVEITVEDNGPGIPPEDLEKIFEPFFRTDKRSRkiggtGLGLSIVKK 83

                           90       100
                   ....*....|....*....|....*.
gi 491000781   506 QLRELGGTLAVESEPGVFTQFFVHLP 531
Cdd:smart00387  84 LVELHGGEISVESEPGGGTTFTITLP 109
HATPase_c pfam02518
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the ...
 431-531 5.35e-19

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.


Pssm-ID: 460579 [Multi-domain]  Cd Length: 109  Bit Score: 82.42  E-value: 5.35e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491000781  431 LVTVLGNLIENALDAMSGQSEGEVGLllhYQNGWLSGEVSDDGPGIPPANIDAIFNKGFS---TKGENRGVGLFLASQQL 507
Cdd:pfam02518   6 LRQVLSNLLDNALKHAAKAGEITVTL---SEGGELTLTVEDNGIGIPPEDLPRIFEPFSTadkRGGGGTGLGLSIVRKLV 82

                          90       100
                  ....*....|....*....|....
gi 491000781  508 RELGGTLAVESEPGVFTQFFVHLP 531
Cdd:pfam02518  83 ELLGGTITVESEPGGGTTVTLTLP 106
nifL_nitrog TIGR02938
nitrogen fixation negative regulator NifL; NifL is a modulator of the nitrogen fixation ...
 438-520 1.21e-06

nitrogen fixation negative regulator NifL; NifL is a modulator of the nitrogen fixation positive regulator protein NifA, and is therefore a negative regulator. It binds NifA. NifA and NifL are encoded by adjacent genes. [Central intermediary metabolism, Nitrogen fixation, Regulatory functions, Protein interactions]


Pssm-ID: 131984 [Multi-domain]  Cd Length: 494  Bit Score: 51.06  E-value: 1.21e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491000781  438 LIENALDAMS--GQSEGEVGLLLHYQNGWLSGEVSDDGPGIPPANIDAIFNKGFSTKG---ENRGVGLFLASQQLRELGG 512
Cdd:TIGR02938 395 LVDNAIEAMNikGWKRRELSITTALNGDLIVVSILDSGPGIPQDLRYKVFEPFFTTKGgsrKHIGMGLSVAQEIVADHGG 474


                  ....*...
gi 491000781  513 TLAVESEP 520
Cdd:TIGR02938 475 IIDLDDDY 482
 
Name Accession Description Interval E-value
PRK11086 PRK11086
sensory histidine kinase DcuS; Provisional
 6-539 0e+00

sensory histidine kinase DcuS; Provisional


Pssm-ID: 236839 [Multi-domain]  Cd Length: 542  Bit Score: 847.27  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491000781   6 ESIPPARKRLMSMKLSTAVTLMISSVIGSVLLLVYALWFIQISDTTRDGVKDTALAVARTFSDMPEVKQALTLPPQSGLI 85
Cdd:PRK11086   2 HSLPYMKKRKRPMKLSTTVTLMVSAVVFSVLLVVHLLYFSQISRMTRDGLAEKALAIARTVADSPIVIQGLQGKPDESGI 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491000781  86 QPLALAITRRNDLLYAVVTDMHGVRYSHPNARLIGKQFIGEDIQPAFNGKENVAVNHGVLAPALRVFTPVFNDQQQQIGV 165
Cdd:PRK11086  82 QTYAEAVRKRNDLLFIVVTDMQGIRYSHPNPQKIGKHFIGGDELPALKGKENVSINRGTLGQALRVFTPVYDENGKQIGV 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491000781 166 VVVGISLSKVDEQIAKGRWDVLLTVLFSALVCGIGTWSLVRGLKRVLLGLEPQEISTQFQQRQAMLHSLKEGVVAVDVEG 245
Cdd:PRK11086 162 VAVGISLSEVTEQINESRWSIYWSILFGALVGLIGTVILVRVLKRILFGLEPYEISTLFEQRQAMLQSIKEGVIAVDDRG 241

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491000781 246 RVTLINPAASEIL--LSG-----PGKEIAHTPLLADLQEVLQTGEPIYDRELGCNGFLLISNTVPVRSQNAIVGAISTFR 318
Cdd:PRK11086 242 EVTLINDEAKRLFnyKKGleddpLGTDVESWMPVSRLKEVLRTGTPRRDEEININGRLLLTNTVPVRVNGEIIGAIATFR 321

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491000781 319 DKTEVSQLLQRLDGMVNYVDALRTTSHEFMNKLHVILGLLNMKSYDKLEEYVLQTAHTYQADIGEIQHRIKSPVVAGFLI 398
Cdd:PRK11086 322 DKTEVRQLAQRLDGMVNYADALRAQSHEFMNKLHVILGLLHLKSYDQLEDYILKTANNYQEEIGSLLGKIKSPVIAGFLL 401

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491000781 399 GKIQRAKERGFTLNLAEESLVPDCPNEKQVTVLVTVLGNLIENALDAMSGQSEGEVGLLLHYQNGWLSGEVSDDGPGIPP 478
Cdd:PRK11086 402 GKISRARELGITLIISEDSQLPDSGDEDQVHELITILGNLIENALEAVGGEEGGEISVSLHYRNGWLHCEVSDDGPGIAP 481

                        490       500       510       520       530       540
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 491000781 479 ANIDAIFNKGFSTKGENRGVGLFLASQQLRELGGTLAVESEPGVFTQFFVHLPWDSKRKRA 539
Cdd:PRK11086 482 DEIDAIFDKGYSTKGSNRGVGLYLVKQSVENLGGSIAVESEPGVGTQFFVQIPWDGERSNR 542
CitA COG3290
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction ...
 184-535 4.05e-112

Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction mechanisms];


Pssm-ID: 442519 [Multi-domain]  Cd Length: 389  Bit Score: 338.36  E-value: 4.05e-112
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491000781 184 WDVLLTVLFSALVCGIGTWSLVRGLKRVLLGLEpQEISTQFQQRQAMLHSLKEGVVAVDVEGRVTLINPAASEILlsgpG 263
Cdd:COG3290   44 LFVIILLLLLLILLLILLLLLLLLLAALLLKLL-EEIARLVEEREAVLESIREGVIAVDRDGRITLINDAARRLL----G 118

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491000781 264 KEIAHTPLLADLQEVLQTGEpiYDRELGCNGFLLISNTVPVRSQNAIVGAISTFRDKTEVSQLLQRLDGMVNYVDALRTT 343
Cdd:COG3290  119 LDAIGRPIDEVLAEVLETGE--RDEEILLNGRVLVVNRVPIRDDGRVVGAVATFRDRTELERLEEELEGVKELAEALRAQ 196

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491000781 344 SHEFMNKLHVILGLLNMKSYDKLEEYVLQTAHTYQADIGEIQHRIKSPVVAGFLIGKIQRAKERGFTLNLAEESLVPDCP 423
Cdd:COG3290  197 RHDFRNHLHTISGLLQLGEYDEALEYIDEISEELQELIDSLLSRIGNPVLAALLLGKAARARERGIDLTIDIDSDLPDLP 276

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491000781 424 neKQVTVLVTVLGNLIENALDAMSGQ--SEGEVGLLLHYQNGWLSGEVSDDGPGIPPANIDAIFNKGFSTK-GENRGVGL 500
Cdd:COG3290  277 --LSDTDLVTILGNLLDNAIEAVEKLpeEERRVELSIRDDGDELVIEVEDSGPGIPEELLEKIFERGFSTKlGEGRGLGL 354

                        330       340       350
                 ....*....|....*....|....*....|....*
gi 491000781 501 FLASQQLRELGGTLAVESEPGVFTQFFVHLPWDSK 535
Cdd:COG3290  355 ALVKQIVEKYGGTIEVESEEGEGTVFTVRLPKEGE 389
dpiB PRK15053
sensor histidine kinase DpiB; Provisional
 49-531 8.02e-63

sensor histidine kinase DpiB; Provisional


Pssm-ID: 185013 [Multi-domain]  Cd Length: 545  Bit Score: 215.08  E-value: 8.02e-63
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491000781  49 DTTRDGVKDTALAVARTFSDMPEVKQALTLPPQSGLIQpLALAITRRNDLLYAVVTDMHGVRYSHPNARLIGKQFIGEDI 128
Cdd:PRK15053  47 DYLTLHVRDMAMNQAKIIASNDSVISAVKTRDYKRLAT-IANKLQRDTDFDYVVIGDRHSIRLYHPNPEKIGYPMQFTKP 125

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491000781 129 QPAFNGKENVAVNHGVLAPALRVFTPVFNDQQQQIGVVVVGISLSKVDEQiakgRWDVLLTvLFSALVCGIG-----TWS 203
Cdd:PRK15053 126 GALEKGESYFITGKGSMGMAMRAKTPIFDDDGKVIGVVSIGYLVSKIDSW----RLEFLLP-MAGVFVVLLGilmllSWF 200

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491000781 204 LVRGLKRVLLGLEPQEISTQFQQRQAMLHSLKEGVVAVDVEGRVTLINPAASEIL-LSGPGKEIAHTPLladlQEVL--- 279
Cdd:PRK15053 201 FAAHIRRQMMGMEPKQIARVVRQQEALFSSVYEGLIAVDPHGYITAINRNARKMLgLSSPGRQWLGKPI----AEVVrpa 276

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491000781 280 -----QTGEPIYDRELGCNGFLLISNTVPVRSQNAIVGAISTFRDKTEVSQLLQRLDGMVNYVDALRTTSHEFMNKLHVI 354
Cdd:PRK15053 277 dffteQIDEKRQDVVANFNGLSVIANREAIRSGDDLLGAIISFRSKDEISTLNAQLTQIKQYVESLRTLRHEHLNWMSTL 356

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491000781 355 LGLLNMKSYDKLEEYVLQTAHTYQADIGEIQHRIKSPVVAGFLIGKIQRAKERGFTLNLAEESLVPDCPNEKQVTVLVTV 434
Cdd:PRK15053 357 NGLLQMKEYDRVLEMVQGESQAQQQLIDSLREAFADRQVAGLLFGKVQRARELGLKMVIVPGSQLSQLPPGLDSTEFAAI 436

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491000781 435 LGNLIENALDAMSGQSEGE--VGLLLHYQNGWLSGEVSDDGPGIPPANIDAIFNKGFSTKGEN---RGVGLFLASQQLRE 509
Cdd:PRK15053 437 VGNLLDNAFEASLRSDEGNkiVELFLSDEGDDVVIEVADQGCGVPESLRDKIFEQGVSTRADEpgeHGIGLYLIASYVTR 516

                        490       500
                 ....*....|....*....|..
gi 491000781 510 LGGTLAVESEPGVFTQFFVHLP 531
Cdd:PRK15053 517 CGGVITLEDNDPCGTLFSIFIP 538
HATPase_DpiB-CitA-like cd16915
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 431-531 5.52e-33

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 DpiB, DcuS, and Bacillus subtilis CitS, DctS, and YufL; This family includes histidine kinase-like ATPase domains of Escherichia coli K-12 DpiB and DcuS, and Bacillus subtilis CitS, DctS and MalK histidine kinases (HKs) all of which are two component transduction systems (TCSs). E. coli K-12 DpiB (also known as CitA) is the histidine kinase (HK) of DpiA-DpiB, a two-component signal transduction system (TCS) required for the expression of citrate-specific fermentation genes and genes involved in plasmid inheritance. E. coli K-12 DcuS (also known as YjdH) is the HK of DcuS-DcuR, a TCS that in the presence of the extracellular C4-dicarboxlates, activates the expression of the genes of anaerobic fumarate respiration and of aerobic C4-dicarboxylate uptake. CitS is the HK of Bacillus subtilis CitS-CitT, a TCS which regulates expression of CitM, the Mg-citrate transporter. Bacillus subtilis DctS forms a tripartite sensor unit (DctS/DctA/DctB) for sensing C4 dicarboxylates. Bacillus subtilis MalK (also known as YfuL) is the HK of MalK-MalR (YufL-YufM) a TCS which regulates the expression of the malate transporters MaeN (YufR) and YflS, and is essential for utilization of malate in minimal medium. Proteins having this DpiB-CitA-like HATPase domain generally have sensor domains such as Cache and PAS, and a histidine kinase A (HisKA)-like SpoOB-type, alpha-helical domain.


Pssm-ID: 340392 [Multi-domain]  Cd Length: 104  Bit Score: 121.24  E-value: 5.52e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491000781 431 LVTVLGNLIENALDAM--SGQSEGEVGLLLHYQNGWLSGEVSDDGPGIPPANIDAIFNKGFSTKGE-NRGVGLFLASQQL 507
Cdd:cd16915    1 LITIVGNLIDNALDALaaTGAPNKQVEVFLRDEGDDLVIEVRDTGPGIAPELRDKVFERGVSTKGQgERGIGLALVRQSV 80

                         90       100
                 ....*....|....*....|....
gi 491000781 508 RELGGTLAVESEPGVFTQFFVHLP 531
Cdd:cd16915   81 ERLGGSITVESEPGGGTTFSIRIP 104
NtrB COG3852
Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms];
228-531 4.38e-32

Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms];


Pssm-ID: 443061 [Multi-domain]  Cd Length: 361  Bit Score: 126.50  E-value: 4.38e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491000781 228 QAMLHSLKEGVVAVDVEGRVTLINPAASEIL-LSGP---GKEIAH-----TPLLADLQEVLQTGEPIYDREL------GC 292
Cdd:COG3852   10 RAILDSLPDAVIVLDADGRITYVNPAAERLLgLSAEellGRPLAElfpedSPLRELLERALAEGQPVTEREVtlrrkdGE 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491000781 293 NGFLLISnTVPVRSQNAIVGAISTFRDKTEVSQL---LQRLDGMVNYVDALRTTSHEFMNKLHVILG---LLNMK-SYDK 365
Cdd:COG3852   90 ERPVDVS-VSPLRDAEGEGGVLLVLRDITERKRLereLRRAEKLAAVGELAAGLAHEIRNPLTGIRGaaqLLERElPDDE 168

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491000781 366 LEEY-----------------VLQTAHTYQA-----DIGEIQHRIKSPVVAGFligkiqrakERGFTLnlaEESLVPDCP 423
Cdd:COG3852  169 LREYtqliieeadrlnnlvdrLLSFSRPRPPerepvNLHEVLERVLELLRAEA---------PKNIRI---VRDYDPSLP 236

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491000781 424 ----NEKQvtvLVTVLGNLIENALDAMSGQseGEVGLLLHYQNGWLSG----------EVSDDGPGIPPANIDAIFNKGF 489
Cdd:COG3852  237 evlgDPDQ---LIQVLLNLVRNAAEAMPEG--GTITIRTRVERQVTLGglrprlyvriEVIDNGPGIPEEILDRIFEPFF 311

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|..
gi 491000781 490 STKGENRGVGLFLASQQLRELGGTLAVESEPGVFTQFFVHLP 531
Cdd:COG3852  312 TTKEKGTGLGLAIVQKIVEQHGGTIEVESEPGKGTTFRIYLP 353
NtrY COG5000
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism ...
 218-531 1.79e-28

Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms];


Pssm-ID: 444024 [Multi-domain]  Cd Length: 422  Bit Score: 117.37  E-value: 1.79e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491000781 218 QEISTQFQQRQAMLHSLKEGVVAVDVEGRVTLINPAASEIL----LSGPGKEIAHTPLLADLQEVLQT-----GEPIYDR 288
Cdd:COG5000   83 EELEERRRYLETILENLPAGVIVLDADGRITLANPAAERLLgiplEELIGKPLEELLPELDLAELLREalergWQEEIEL 162

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491000781 289 ELGCNGFLLISNTvPVRSQNAIVgaisTFRDKTEVSQLlQRLDgmvnyvdAL----RTTSHEFMNKLHVI---LGLLNMK 361
Cdd:COG5000  163 TRDGRRTLLVRAS-PLRDDGYVI----VFDDITELLRA-ERLA-------AWgelaRRIAHEIKNPLTPIqlsAERLRRK 229

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491000781 362 SYDKLE---EYVLQTAHTYQADIGEIQH---------RIKSPVV-----------AGFLIGKIQRAKERGFTLNLAEESL 418
Cdd:COG5000  230 LADKLEedrEDLERALDTIIRQVDRLKRivdefldfaRLPEPQLepvdlnellreVLALYEPALKEKDIRLELDLDPDLP 309

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491000781 419 VPDCpNEKQvtvLVTVLGNLIENALDAMSGQseGEVGLLLHYQNGWLSGEVSDDGPGIPPANIDAIFNKGFSTKGENRGV 498
Cdd:COG5000  310 EVLA-DRDQ---LEQVLINLLKNAIEAIEEG--GEIEVSTRREDGRVRIEVSDNGPGIPEEVLERIFEPFFTTKPKGTGL 383

                        330       340       350
                 ....*....|....*....|....*....|...
gi 491000781 499 GLFLASQQLRELGGTLAVESEPGVFTQFFVHLP 531
Cdd:COG5000  384 GLAIVKKIVEEHGGTIELESRPGGGTTFTIRLP 416
PRK11360 PRK11360
two-component system sensor histidine kinase AtoS;
172-538 2.65e-26

two-component system sensor histidine kinase AtoS;


Pssm-ID: 236901 [Multi-domain]  Cd Length: 607  Bit Score: 113.14  E-value: 2.65e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491000781 172 LSKVDEQIAKGRWDVLLtVLFSALVCGIG-TWSLVR-----------GLKRV----------LLGlEPQEIS---TQFQQ 226
Cdd:PRK11360 178 TEDIRRQAWKMDRRIYA-VLAAGLVIGLLlIFLLSRrfsanvdiikdGLSTLendlstrlppLPG-ELGEISqaiNNLAQ 255

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491000781 227 R--------QAMLHSLKEGVVAVDVEGRVTLINPAASEILLSGP----GKEIA-----HTPLLADLQEVLQTGEPIYDRE 289
Cdd:PRK11360 256 AlretrslnELILESIADGVIAIDRQGKITTMNPAAEVITGLQRhelvGKPYSelfppNTPFASPLLDTLEHGTEHVDLE 335

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491000781 290 LGCNGF-----LLISNTVPVRSQNAIVGAISTFRDKTEVSQLLQRldgmVNYVDALRT-------TSHEFMNKLHVILGL 357
Cdd:PRK11360 336 ISFPGRdrtieLSVSTSLLHNTHGEMIGALVIFSDLTERKRLQRR----VARQERLAAlgelvagVAHEIRNPLTAIRGY 411

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491000781 358 LNMksydkLEEYVLQTAHT-YQADIGEIQHRIKSPVVAGFLIGKIQRAKERGFTLN-LAEESLVPDCPNEKQVTVLVT-- 433
Cdd:PRK11360 412 VQI-----WRQQTSDPPSQeYLSVVLREVDRLNKVIDQLLEFSRPRESQWQPVSLNaLVEEVLQLFQTAGVQARVDFEte 486

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491000781 434 -----------------VLGNLIENALDAMSGqsEGEVGLLLHY-QNGWLSGEVSDDGPGIPPANIDAIFNKGFSTKGEN 495
Cdd:PRK11360 487 ldnelppiwadpellkqVLLNILINAVQAISA--RGKIRIRTWQySDGQVAVSIEDNGCGIDPELLKKIFDPFFTTKAKG 564

                        410       420       430       440
                 ....*....|....*....|....*....|....*....|...
gi 491000781 496 RGVGLFLASQQLRELGGTLAVESEPGVFTQFFVHLPWDSKRKR 538
Cdd:PRK11360 565 TGLGLALSQRIINAHGGDIEVESEPGVGTTFTLYLPINPQGNQ 607
COG4191 COG4191
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal ...
 434-531 2.48e-21

Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms];


Pssm-ID: 443345 [Multi-domain]  Cd Length: 361  Bit Score: 95.64  E-value: 2.48e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491000781 434 VLGNLIENALDAMSGQSEGEVGLLLHYQNGWLSGEVSDDGPGIPPANIDAIFNKGFSTKGENRGVGLFLA-SQQL-RELG 511
Cdd:COG4191  260 VLLNLLINAIDAMEEGEGGRITISTRREGDYVVISVRDNGPGIPPEVLERIFEPFFTTKPVGKGTGLGLSiSYGIvEKHG 339

                         90       100
                 ....*....|....*....|
gi 491000781 512 GTLAVESEPGVFTQFFVHLP 531
Cdd:COG4191  340 GRIEVESEPGGGTTFTITLP 359
HATPase_c smart00387
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
 431-531 5.74e-21

Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.


Pssm-ID: 214643 [Multi-domain]  Cd Length: 111  Bit Score: 88.09  E-value: 5.74e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491000781   431 LVTVLGNLIENALDAMsgQSEGEVGLLLHYQNGWLSGEVSDDGPGIPPANIDAIFNKGFSTKGENR-----GVGLFLASQ 505
Cdd:smart00387   6 LRQVLSNLLDNAIKYT--PEGGRITVTLERDGDHVEITVEDNGPGIPPEDLEKIFEPFFRTDKRSRkiggtGLGLSIVKK 83

                           90       100
                   ....*....|....*....|....*.
gi 491000781   506 QLRELGGTLAVESEPGVFTQFFVHLP 531
Cdd:smart00387  84 LVELHGGEISVESEPGGGTTFTITLP 109
BaeS COG0642
Signal transduction histidine kinase [Signal transduction mechanisms];
253-531 2.27e-20

Signal transduction histidine kinase [Signal transduction mechanisms];


Pssm-ID: 440407 [Multi-domain]  Cd Length: 328  Bit Score: 92.28  E-value: 2.27e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491000781 253 AASEILLSGPGKEIAHTPLLADLQEVLQTGEPIYDRELGCNGFLLISNTVPVRSQNAIVGAISTFRDKTEVSQLLQRLDG 332
Cdd:COG0642   29 LLLLALLLLLALLLLLLLLLLLLLLLALALLALLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLALLLLLEEANE 108

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491000781 333 MVNyvDALRTTSHEFMNKLHVILGLLNMksydkLEEYVLQTAHTYQADIGEIQHRIKSpVVAGFL-IGKIQRAKERGF-- 409
Cdd:COG0642  109 AKS--RFLANVSHELRTPLTAIRGYLEL-----LLEELDEEQREYLETILRSADRLLR-LINDLLdLSRLEAGKLELEpe 180

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491000781 410 TLNLAE--ESLVPDC---PNEKQVTV-----------------LVTVLGNLIENALDAMsgQSEGEVGLLLHYQNGWLSG 467
Cdd:COG0642  181 PVDLAEllEEVVELFrplAEEKGIELeldlpddlptvrgdpdrLRQVLLNLLSNAIKYT--PEGGTVTVSVRREGDRVRI 258

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 491000781 468 EVSDDGPGIPPANIDAIFNKGFSTKGENR----GVGLFLASQQLRELGGTLAVESEPGVFTQFFVHLP 531
Cdd:COG0642  259 SVEDTGPGIPPEDLERIFEPFFRTDPSRRgggtGLGLAIVKRIVELHGGTIEVESEPGKGTTFTVTLP 326
HATPase cd00075
Histidine kinase-like ATPase domain; This superfamily includes the histidine kinase-like ...
 431-530 3.84e-19

Histidine kinase-like ATPase domain; This superfamily includes the histidine kinase-like ATPase (HATPase) domains of several ATP-binding proteins such as histidine kinase, DNA gyrase B, topoisomerases, heat shock protein 90 (HSP90), phytochrome-like ATPases and DNA mismatch repair proteins. Domains belonging to this superfamily are also referred to as GHKL (gyrase, heat-shock protein 90, histidine kinase, MutL) ATPase domains.


Pssm-ID: 340391 [Multi-domain]  Cd Length: 102  Bit Score: 82.65  E-value: 3.84e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491000781 431 LVTVLGNLIENALDAMSgqSEGEVGLLLHYQNGWLSGEVSDDGPGIPPANIDAIFNKGFSTK----GENRGVGLFLASQQ 506
Cdd:cd00075    1 LEQVLSNLLDNALKYSP--PGGTIEISLRQEGDGVVLEVEDNGPGIPEEDLERIFERFYRGDksreGGGTGLGLAIVRRI 78

                         90       100
                 ....*....|....*....|....
gi 491000781 507 LRELGGTLAVESEPGVFTQFFVHL 530
Cdd:cd00075   79 VEAHGGRITVESEPGGGTTFTVTL 102
KdpD COG2205
K+-sensing histidine kinase KdpD [Signal transduction mechanisms];
325-531 3.97e-19

K+-sensing histidine kinase KdpD [Signal transduction mechanisms];


Pssm-ID: 441807 [Multi-domain]  Cd Length: 239  Bit Score: 86.50  E-value: 3.97e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491000781 325 QLLQRLDGMVNyvDALRTTSHEFMNKLHVILGLLNM------KSYDKLEEYvLQTAHT---------------YQADIGE 383
Cdd:COG2205    7 EELEELERLKS--EFLANVSHELRTPLTSILGAAELlldeedLSPEERREL-LEIIREsaerllrliedlldlSRLESGK 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491000781 384 IQHRiKSPVVAGFLIGKI-----QRAKERG--FTLNLAEESLVPDCPNEKqvtvLVTVLGNLIENALDAmsGQSEGEVGL 456
Cdd:COG2205   84 LSLE-LEPVDLAELLEEAveelrPLAEEKGirLELDLPPELPLVYADPEL----LEQVLANLLDNAIKY--SPPGGTITI 156

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 491000781 457 LLHYQNGWLSGEVSDDGPGIPPANIDAIFNKGFSTKGENR----GVGLFLASQQLRELGGTLAVESEPGVFTQFFVHLP 531
Cdd:COG2205  157 SARREGDGVRISVSDNGPGIPEEELERIFERFYRGDNSRGeggtGLGLAIVKRIVEAHGGTIWVESEPGGGTTFTVTLP 235
HATPase_c pfam02518
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the ...
 431-531 5.35e-19

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.


Pssm-ID: 460579 [Multi-domain]  Cd Length: 109  Bit Score: 82.42  E-value: 5.35e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491000781  431 LVTVLGNLIENALDAMSGQSEGEVGLllhYQNGWLSGEVSDDGPGIPPANIDAIFNKGFS---TKGENRGVGLFLASQQL 507
Cdd:pfam02518   6 LRQVLSNLLDNALKHAAKAGEITVTL---SEGGELTLTVEDNGIGIPPEDLPRIFEPFSTadkRGGGGTGLGLSIVRKLV 82

                          90       100
                  ....*....|....*....|....
gi 491000781  508 RELGGTLAVESEPGVFTQFFVHLP 531
Cdd:pfam02518  83 ELLGGTITVESEPGGGTTVTLTLP 106
KinE COG5809
Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome ...
 217-531 4.63e-18

Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];


Pssm-ID: 444511 [Multi-domain]  Cd Length: 489  Bit Score: 86.95  E-value: 4.63e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491000781 217 PQEISTQFQQ-RQAMLHSlKEGVVAVDVEGRVTLINPAASEIL-----------LSGPGKEIAHTPLLADLQEVLQTGEP 284
Cdd:COG5809  133 EEALRESEEKfRLIFNHS-PDGIIVTDLDGRIIYANPAACKLLgisieeligksILELIHSDDQENVAAFISQLLKDGGI 211

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491000781 285 IY--DRELGCNG--FLLISNTVPVRSQNAIVGAISTFRDKTEVSQLLQRLdgmvNYVDALR-------TTSHEFMNKLHV 353
Cdd:COG5809  212 AQgeVRFWTKDGrwRLLEASGAPIKKNGEVDGIVIIFRDITERKKLEELL----RKSEKLSvvgelaaGIAHEIRNPLTS 287

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491000781 354 ILGLLNMKSYDKLEEYvlqtAHTYQADIGEIQhRIKSpVVAGFLI-GKIQRAKERGFTLNLAEESLVP------------ 420
Cdd:COG5809  288 LKGFIQLLKDTIDEEQ----KTYLDIMLSELD-RIES-IISEFLVlAKPQAIKYEPKDLNTLIEEVIPllqpqallknvq 361

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491000781 421 -------DCP----NEKQvtvLVTVLGNLIENALDAMSGQseGEVGLLLHYQ-NGWLSGEVSDDGPGIPPANIDAIFNKG 488
Cdd:COG5809  362 ieleledDIPdilgDENQ---LKQVFINLLKNAIEAMPEG--GNITIETKAEdDDKVVISVTDEGCGIPEERLKKLGEPF 436

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|...
gi 491000781 489 FSTKGENRGVGLFLASQQLRELGGTLAVESEPGVFTQFFVHLP 531
Cdd:COG5809  437 YTTKEKGTGLGLMVSYKIIEEHGGKITVESEVGKGTTFSITLP 479
HATPase_HupT_MifS-like cd16976
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 434-530 3.00e-16

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhodobacter capsulatus HupT and Pseudomonas aeruginosa MifS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Rhodobacter capsulatus HupT of the HupT-HupR two-component regulatory system (TCS), which regulates the synthesis of HupSL, a membrane bound [NiFe]hydrogenase. It also contains the HATPase domain of Pseudomonas aeruginosa MifS, the HK of the MifS-MifR TCS, which may be involved in sensing alpha-ketoglutarate and regulating its transport and subsequent metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some also have a C-terminal PAS sensor domain.


Pssm-ID: 340435 [Multi-domain]  Cd Length: 102  Bit Score: 74.42  E-value: 3.00e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491000781 434 VLGNLIENALDAMSGQSEGEVGLLLHYQNGWLSGEVSDDGPGIPPANIDAIFNKGFSTK--GENRGVGLFLASQQLRELG 511
Cdd:cd16976    4 VLMNLLQNALDAMGKVENPRIRIAARRLGGRLVLVVRDNGPGIAEEHLSRVFDPFFTTKpvGKGTGLGLSISYGIVEEHG 83

                         90
                 ....*....|....*....
gi 491000781 512 GTLAVESEPGVFTQFFVHL 530
Cdd:cd16976   84 GRLSVANEEGAGARFTFDL 102
RocR COG3829
RocR-type transcriptional regulator, contains PAS, AAA-type ATPase, and DNA-binding Fis ...
 215-333 3.08e-16

RocR-type transcriptional regulator, contains PAS, AAA-type ATPase, and DNA-binding Fis domains [Transcription, Signal transduction mechanisms];


Pssm-ID: 443041 [Multi-domain]  Cd Length: 448  Bit Score: 80.97  E-value: 3.08e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491000781 215 LEPQEISTQFQqrqAMLHSLKEGVVAVDVEGRVTLINPAASEIlLSGPGKEIAHTPLLAD-----LQEVLQTGEPIYDRE 289
Cdd:COG3829    4 LELKELEEELE---AILDSLDDGIIVVDADGRITYVNRAAERI-LGLPREEVIGKNVTELipnspLLEVLKTGKPVTGVI 79

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 491000781 290 LGCNGFL--LISNTVPVRSQNAIVGAISTFRDKTEVSQLLQRLDGM 333
Cdd:COG3829   80 QKTGGKGktVIVTAIPIFEDGEVIGAVETFRDITELKRLERKLREE 125
KinA COG5805
Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle ...
 219-531 2.48e-14

Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];


Pssm-ID: 444507 [Multi-domain]  Cd Length: 496  Bit Score: 75.54  E-value: 2.48e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491000781 219 EISTQFQQRQAMLHSLKEGVVAVDVEGRVTLINPA------ASEILLSG-PGKEIAHTPLLADLQEVLQTGEP-----IY 286
Cdd:COG5805  151 ILQEQEERLQTLIENSPDLICVIDTDGRILFINESierlfgAPREELIGkNLLELLHPCDKEEFKERIESITEvwqefII 230

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491000781 287 DRE-LGCNGFLLI--SNTVPVRSQN-AIVGAISTFRD---KTEVSQLLQRLDgMVNYVDALRTT-SHEFMNKLHVILGLL 358
Cdd:COG5805  231 EREiITKDGRIRYfeAVIVPLIDTDgSVKGILVILRDiteKKEAEELMARSE-KLSIAGQLAAGiAHEIRNPLTSIKGFL 309

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491000781 359 N-MKSydKLEEYvlqtAHTYQADIGEIQhRIKS----------PVVAGF----LIGKIQR--------AKERGFTLNLAE 415
Cdd:COG5805  310 QlLQP--GIEDK----EEYFDIMLSELD-RIESiiseflalakPQAVNKekenINELIQDvvtlleteAILHNIQIRLEL 382

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491000781 416 ESLVPD--CpNEKQvtvLVTVLGNLIENALDAMsgQSEGEVGLLLHYQNGWLSGEVSDDGPGIPPANIDAIFNKGFSTKG 493
Cdd:COG5805  383 LDEDPFiyC-DENQ---IKQVFINLIKNAIEAM--PNGGTITIHTEEEDNSVIIRVIDEGIGIPEERLKKLGEPFFTTKE 456

                        330       340       350
                 ....*....|....*....|....*....|....*...
gi 491000781 494 ENRGVGLFLASQQLRELGGTLAVESEPGVFTQFFVHLP 531
Cdd:COG5805  457 KGTGLGLMVSYKIIENHNGTIDIDSKVGKGTTFTITLP 494
WalK COG5002
Sensor histidine kinase WalK [Signal transduction mechanisms];
186-531 4.37e-14

Sensor histidine kinase WalK [Signal transduction mechanisms];


Pssm-ID: 444026 [Multi-domain]  Cd Length: 390  Bit Score: 74.20  E-value: 4.37e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491000781 186 VLLTVLFSALVCGIGTWSLVRGLKRVLLGLEPQEISTQFQQRQAMLHSLKEGVVAVDVEGRVTLINPAASEILLSGPGKE 265
Cdd:COG5002   24 LLLLLLLLLLLLLLLLLLLLLLLLLLLLLALLLLLLLLLLLLLALLLLLLLLLLLLALALLLLALLLLLLLLLLLLALLI 103

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491000781 266 IAHTPLLADLQEVLQTGEPIYDRELGcngFLLISNTVPVRSQNAIVGAISTFRDKTEVSQLLQRLDGMVNYVdalrttSH 345
Cdd:COG5002  104 LLLLLALLILLAALLLLLSELLLLLL---LLGRLSLRLSALLLGLLLLAAVERDITELERLEQMRREFVANV------SH 174

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491000781 346 EFMNKLHVILGLL------NMKSYDKLEEYvLQTAHT---------------YQADIGEIQHRiKSPVVAGFLIGKI--- 401
Cdd:COG5002  175 ELRTPLTSIRGYLellldgAADDPEERREY-LEIILEeaerlsrlvndlldlSRLESGELKLE-KEPVDLAELLEEVvee 252

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491000781 402 --QRAKERGFTLNLaeeslvpDCPNEKqVTV------LVTVLGNLIENALDAmsGQSEGEVGLLLHYQNGWLSGEVSDDG 473
Cdd:COG5002  253 lrPLAEEKGIELEL-------DLPEDP-LLVlgdpdrLEQVLTNLLDNAIKY--TPEGGTITVSLREEDDQVRISVRDTG 322

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 491000781 474 PGIPPANIDAIF------NKGFSTKGENRGVGLFLASQQLRELGGTLAVESEPGVFTQFFVHLP 531
Cdd:COG5002  323 IGIPEEDLPRIFerfyrvDKSRSRETGGTGLGLAIVKHIVEAHGGRIWVESEPGKGTTFTITLP 386
HATPase_AtoS-like cd16943
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 431-531 7.23e-14

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 AtoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Escherichia coli AtoS, an HK of the AtoS-AtoC TCS. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have accessory domains such as HAMP or PAS sensor domains or CBS-pair domains.


Pssm-ID: 340419 [Multi-domain]  Cd Length: 105  Bit Score: 67.83  E-value: 7.23e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491000781 431 LVTVLGNLIENALDAMSGQSEGEVGLLLHYQNGWLsgEVSDDGPGIPPANIDAIFNKGFSTK--GENRGVGLFLASQQLR 508
Cdd:cd16943    4 LNQVLLNLLVNAAQAMEGRGRITIRTWAHVDQVLI--EVEDTGSGIDPEILGRIFDPFFTTKpvGEGTGLGLSLSYRIIQ 81

                         90       100
                 ....*....|....*....|...
gi 491000781 509 ELGGTLAVESEPGVFTQFFVHLP 531
Cdd:cd16943   82 KHGGTIRVASVPGGGTRFTIILP 104
HATPase_EvgS-ArcB-TorS-like cd16922
Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid ...
 434-531 2.21e-12

Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid sensor histidine kinases, similar to Escherichia coli EvgS, ArcB, TorS, BarA, RcsC; This family contains the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinases (HKs), including the following Escherichia coli HKs: EvgS, a HK of the EvgS-EvgA two-component system (TCS) that confers acid resistance; ArcB, a HK of the ArcB-ArcA TCS that modulates the expression of numerous genes in response to respiratory growth conditions; TorS, a HK of the TorS-TorR TCS which is involved in the anaerobic utilization of trimethylamine-N-oxide; BarA, a HK of the BarA-UvrY TCS involved in the regulation of carbon metabolism; and RcsC, a HK of the RcsB-RcsC TCS which regulates the expression of the capsule operon and of the cell division gene ftsZ. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), with most having accessory sensor domain(s) such as GAF, PAS and CHASE; many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.


Pssm-ID: 340399 [Multi-domain]  Cd Length: 110  Bit Score: 63.67  E-value: 2.21e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491000781 434 VLGNLIENAL---DamsgqsEGEVGLLLHYQN-----GWLSGEVSDDGPGIPPANIDAIFNK----GFSTKGENRGVGLF 501
Cdd:cd16922    4 ILLNLLGNAIkftE------EGEVTLRVSLEEeeedgVQLRFSVEDTGIGIPEEQQARLFEPfsqaDSSTTRKYGGTGLG 77

                         90       100       110
                 ....*....|....*....|....*....|..
gi 491000781 502 LA-SQQLREL-GGTLAVESEPGVFTQFFVHLP 531
Cdd:cd16922   78 LAiSKKLVELmGGDISVESEPGQGSTFTFTLP 109
PRK10364 PRK10364
two-component system sensor histidine kinase ZraS;
402-537 1.53e-11

two-component system sensor histidine kinase ZraS;


Pssm-ID: 236674 [Multi-domain]  Cd Length: 457  Bit Score: 66.35  E-value: 1.53e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491000781 402 QRAKERGFTLNLAEESLVPDCPNEKQVtvLVTVLGNLIENALDAMSGQSEGEVGLLLHYQNGWLSgeVSDDGPGIPPANI 481
Cdd:PRK10364 322 QDANSREIQLRFTANDTLPEIQADPDR--LTQVLLNLYLNAIQAIGQHGVISVTASESGAGVKIS--VTDSGKGIAADQL 397

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 491000781 482 DAIFNKGFSTKGENRGVGLFLASQQLRELGGTLAVESEPGVFTQFFVHLPWDSKRK 537
Cdd:PRK10364 398 EAIFTPYFTTKAEGTGLGLAVVHNIVEQHGGTIQVASQEGKGATFTLWLPVNITRR 453
HATPase_Glnl-NtrB-like cd16918
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 431-531 1.54e-11

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli GlnL (synonyms NtrB and NRII); This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs), similar to Escherichia coli GlnL/NtrB/NRII HK of the two-component regulatory system (TCS) GlnL/GlnG (NtrB-NtrC, or NRII-NRI), which regulates the transcription of genes encoding metabolic enzymes and permeases in response to carbon and nitrogen status in E. coli and related bacteria. Also included in this family are Rhodobacter capsulatus NtrB, Azospirillum brasilense NtrB, Vibrio alginolyticus NtrB, Rhizobium leguminosarum biovar phaseoli NtrB, and Herbaspirillum seropedicae NtrB. Escherichia coli GlnL/NtrB/NRII is both a kinase and a phosphatase, catalyzing the phosphorylation and dephosphorylation of GlnG/NtrC/NRI. The kinase and phosphatase activities of GlnL/NtrB/NRII are regulated by the PII signal transduction protein, which on binding to GlnL/NtrB/NRII, inhibits the kinase activity of GlnL/NtrB/NRII and activates the GlnL/NtrB/NRII phosphatase activity. Proteins having this HATPase domain also have a histidine kinase dimerization and phosphoacceptor domain (HisKA); some also contain PAS sensor domain(s).


Pssm-ID: 340395 [Multi-domain]  Cd Length: 109  Bit Score: 61.26  E-value: 1.54e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491000781 431 LVTVLGNLIENALDAMSGqSEGEVGLLLHYQNGW----------LSGEVSDDGPGIPPANIDAIFNKGFSTKGENRGVGL 500
Cdd:cd16918    1 LIQVFLNLVRNAAQALAG-SGGEIILRTRTQRQVtlghprhrlaLRVSVIDNGPGIPPDLQDTIFYPMVSGRENGTGLGL 79

                         90       100       110
                 ....*....|....*....|....*....|.
gi 491000781 501 FLASQQLRELGGTLAVESEPGvFTQFFVHLP 531
Cdd:cd16918   80 AIAQNIVSQHGGVIECDSQPG-HTVFSVSLP 109
HATPase_BvrS-ChvG-like cd16953
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 431-531 2.17e-11

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Brucella abortus BvrS and Sinorhizobium meliloti ChvG; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Brucella abortus BvrS of the BvrR-BvrS two-component regulatory system (TCS), which controls cell invasion and intracellular survival, as well as Sinorhizobium meliloti and Agrobacterium tumefaciens ChvG of the ChvI-ChvG TCS necessary for endosymbiosis and pathogenicity in plants. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), an accessory HAMP sensor domain, a periplasmic stimulus-sensing domain, and some also have a sensor N-terminal transmembrane domain.


Pssm-ID: 340429 [Multi-domain]  Cd Length: 110  Bit Score: 60.66  E-value: 2.17e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491000781 431 LVTVLGNLIENALdAMSGQSEGEVGLLLHYQNGWLSGEVSDDGPGIPPANIDAIFNKGFSTK------GENRGVGLFLAS 504
Cdd:cd16953    1 LGQVLRNLIGNAI-SFSPPDTGRITVSAMPTGKMVTISVEDEGPGIPQEKLESIFDRFYTERpaneafGQHSGLGLSISR 79

                         90       100       110
                 ....*....|....*....|....*....|.
gi 491000781 505 QQLRELGGTLAVE--SEPGVFT--QFFVHLP 531
Cdd:cd16953   80 QIIEAHGGISVAEnhNQPGQVIgaRFTVQLP 110
HATPase_TmoS-FixL-DctS-like cd16920
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 434-531 3.17e-11

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhizobium meliloti FixL, and Rhodobacter capsulatus DctS; includes hybrid sensor histidine kinase similar to Pseudomonas mendocina TmoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs), such as Pseudomonas mendocina TmoS HK of the TmoS-TmoT TCS, which controls the expression of the toluene-4-monooxygenase pathway, Rhizobium meliloti FixL HK of the FixL-FixJ TCS, which regulates the expression of the genes related to nitrogen fixation in the root nodule in response to O(2) levels, and Rhodobacter capsulatus DctS of the DctS-DctR TCS, which controls synthesis of the high-affinity C4-dicarboxylate transport system. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and PAS sensor domain(s); many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.


Pssm-ID: 340397 [Multi-domain]  Cd Length: 104  Bit Score: 60.10  E-value: 3.17e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491000781 434 VLGNLIENALDAMS-GQSEGEVGLLLHYQN--GWLSGEVSDDGPGIPPANIDAIFNKGFSTKGENRGVGLFLASQQLREL 510
Cdd:cd16920    4 VLINLVRNGIEAMSeGGCERRELTIRTSPAddRAVTISVKDTGPGIAEEVAGQLFDPFYTTKSEGLGMGLSICRSIIEAH 83

                         90       100
                 ....*....|....*....|.
gi 491000781 511 GGTLAVESEPGVFTQFFVHLP 531
Cdd:cd16920   84 GGRLSVESPAGGGATFQFTLP 104
PRK13837 PRK13837
two-component system VirA-like sensor kinase;
309-535 7.58e-11

two-component system VirA-like sensor kinase;


Pssm-ID: 237526 [Multi-domain]  Cd Length: 828  Bit Score: 65.08  E-value: 7.58e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491000781 309 AIVGAISTFRDKTEVSQLLQRLDgMVNYVDALRT----TSHEFMNKLHVILGLLNM-----KSYDKLEEYVLQTAHTYQA 379
Cdd:PRK13837 420 CLAHAIERRRLETERDALERRLE-HARRLEAVGTlasgIAHNFNNILGAILGYAEMalnklARHSRAARYIDEIISAGAR 498

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491000781 380 ---------DIGEIQHRIKSPVVAGFLIGKI----QRAKERGFTLNL---AEESLVPDCPNEKQVTVLvtvlgNLIENAL 443
Cdd:PRK13837 499 arliidqilAFGRKGERNTKPFDLSELVTEIapllRVSLPPGVELDFdqdQEPAVVEGNPAELQQVLM-----NLCSNAA 573

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491000781 444 DAMSGQSEGEVGLLLHY---QNGWLSGE----------VSDDGPGIPPANIDAIFNKGFSTKGENRGVGLFLASQQLREL 510
Cdd:PRK13837 574 QAMDGAGRVDISLSRAKlraPKVLSHGVlppgryvllrVSDTGAGIDEAVLPHIFEPFFTTRAGGTGLGLATVHGIVSAH 653

                        250       260
                 ....*....|....*....|....*
gi 491000781 511 GGTLAVESEPGVFTQFFVHLPWDSK 535
Cdd:PRK13837 654 AGYIDVQSTVGRGTRFDVYLPPSSK 678
sCache_3_2 pfam17203
Single cache domain 3; This domain is associated to sensor histidine kinases and recognizes ...
 58-156 2.34e-10

Single cache domain 3; This domain is associated to sensor histidine kinases and recognizes citrate and TCA cycle intermediates, Ag(II), Zn(II), Mg(II) (Matilla et al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).


Pssm-ID: 435783 [Multi-domain]  Cd Length: 140  Bit Score: 58.58  E-value: 2.34e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491000781   58 TALAVARTFSDMPEVKQALTLPPQSGLIQPLALAITRRNDLLYAVVTDMHGVRYSHPNARLIGKQFIGEDIQPAF-NGKE 136
Cdd:pfam17203  13 RALALARSVAASPVVRVALTDPEPYPGLQALVESVRRITGADYVVIADRRGRVLAHPDPERVGRRLSGPATAPALtAGRS 92

                          90       100
                  ....*....|....*....|
gi 491000781  137 NVAVNHGVLAPALRVFTPVF 156
Cdd:pfam17203  93 YTGTVTGTLGPSLDAKLPIF 112
HATPase_BceS-YxdK-YvcQ-like cd16948
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 431-531 2.31e-09

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis BceS, YxdK, and Bacillus thuringiensis YvcQ; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis BceS and Bacillus thuringiensis YvcQ, the HKs of the two-component regulatory system (TCSs) BceS-BceR and YvcQ-YvcP, repsectively, which are both involved in regulating bacitracin resistance. It also includes the HATPase domain of YxdK, the HK of YxdK-YxdJ TCS involved in sensing antimicrobial compounds.


Pssm-ID: 340424 [Multi-domain]  Cd Length: 109  Bit Score: 54.98  E-value: 2.31e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491000781 431 LVTVLGNLIENALDAMSGQSEGEVGLLLHYQNGWLSgeVSDDGPGIPPANIDAIFNKGFStkGENR-------GVGLFLA 503
Cdd:cd16948    6 LSFIIGQIVSNALKYSKQGGKIEIYSETNEQGVVLS--IKDFGIGIPEEDLPRVFDKGFT--GENGrnfqestGMGLYLV 81

                         90       100
                 ....*....|....*....|....*...
gi 491000781 504 SQQLRELGGTLAVESEPGVFTQFFVHLP 531
Cdd:cd16948   82 KKLCDKLGHKIDVESEVGEGTTFTITFP 109
HATPase_CckA-like cd16919
Histidine kinase-like ATPase domain of two-component sensor hybrid histidine kinases, similar ...
 431-531 2.32e-09

Histidine kinase-like ATPase domain of two-component sensor hybrid histidine kinases, similar to Brucella abortus 2308 CckA; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinase (HKs) similar to Brucella abortus 2308 CckA, which is a component of an essential protein phosphorelay that regulates expression of genes required for growth, division, and intracellular survival; phosphoryl transfer initiates from the sensor kinase CckA and proceeds via the ChpT phosphotransferase to two regulatory substrates: the DNA-binding response regulator CtrA and the phospho-receiver protein CpdR. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), a REC signal receiver domain, and some contain PAS or PAS and GAF sensor domain(s).


Pssm-ID: 340396 [Multi-domain]  Cd Length: 116  Bit Score: 55.08  E-value: 2.32e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491000781 431 LVTVLGNLIENALDAM--SGQSEGEV-------GLLLHYQN----GWLSGEVSDDGPGIPPANIDAIFNKGFSTKGENRG 497
Cdd:cd16919    1 LELAILNLAVNARDAMpeGGRLTIETsnqrvdaDYALNYRDlipgNYVCLEVSDTGSGMPAEVLRRAFEPFFTTKEVGKG 80

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 491000781 498 VGLFLASQQ--LRELGGTLAVESEPGVFTQFFVHLP 531
Cdd:cd16919   81 TGLGLSMVYgfVKQSGGHLRIYSEPGVGTTVRIYLP 116
HATPase_PhoQ-like cd16954
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 399-520 6.25e-09

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG. PhoQ is the histidine kinase (HK) of the PhoP-PhoQ two-component regulatory system (TCS), which responds to the levels of Mg2+ and Ca2+, controls virulence, mediates the adaptation to Mg2+-limiting environments, and regulates numerous cellular activities. Providencia stuartii AarG is a putative sensor kinase which controls the expression of the 2'-N-acetyltransferase and an intrinsic multiple antibiotic resistance (Mar) response in Providencia stuartii. The AarG product is similar to PhoQ in that it is able to restore wild-type levels of resistance to a Salmonella typhimurium phoQ mutant. However, the expression of the 2'-N-acetyltransferase gene and of aarP (a gene encoding a transcriptional activator of 2'-N-acetyltransferase) are not significantly affected by the levels of Mg2+ or Ca2+. Most proteins in this group contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have an accessory HAMP sensor domain, and some have an intracellular membrane -interaction PhoQ sensor domain.


Pssm-ID: 340430 [Multi-domain]  Cd Length: 135  Bit Score: 54.56  E-value: 6.25e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491000781 399 GKIQRAKERGFTLNLAEESLVPDCPNEkqvtvLVTVLGNLIENALDAMSGQsegeVGLLLHYQNGWLSGEVSDDGPGIPP 478
Cdd:cd16954   11 NKVYQRKGVSISLDISPELRFPGERND-----LMELLGNLLDNACKWCLEF----VEVTARQTDGGLHLIVDDDGPGVPE 81

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 491000781 479 ANIDAIFNKG--FSTKGENRGVGLFLASQQLRELGGTLAVESEP 520
Cdd:cd16954   82 SQRSKIFQRGqrLDEQRPGQGLGLAIAKEIVEQYGGELSLSDSP 125
COG4251 COG4251
Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal ...
 431-531 6.97e-09

Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms];


Pssm-ID: 443393 [Multi-domain]  Cd Length: 503  Bit Score: 58.26  E-value: 6.97e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491000781 431 LVTVLGNLIENALDAMSGQSEGEVGLLLHYQNGWLSGEVSDDGPGIPPANIDAIFN--KGFSTKGENR--GVGLFLASQQ 506
Cdd:COG4251  395 LRQVFQNLISNAIKYSRPGEPPRIEIGAEREGGEWVFSVRDNGIGIDPEYAEKIFEifQRLHSRDEYEgtGIGLAIVKKI 474

                         90       100
                 ....*....|....*....|....*
gi 491000781 507 LRELGGTLAVESEPGVFTQFFVHLP 531
Cdd:COG4251  475 VERHGGRIWVESEPGEGATFYFTLP 499
YesM COG2972
Sensor histidine kinase YesM [Signal transduction mechanisms];
345-531 8.57e-09

Sensor histidine kinase YesM [Signal transduction mechanisms];


Pssm-ID: 442211 [Multi-domain]  Cd Length: 445  Bit Score: 57.72  E-value: 8.57e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491000781 345 HEFMNKLHVILGLLNMKSYDKLEEYVLQTAHTYQADIG----------EIQHrIKSpvvagFLIGKIQRAKERgFTLNLA 414
Cdd:COG2972  254 HFLFNTLNSIRWLAELEDPEEAEEMLEALSKLLRYSLSkgdelvtleeELEL-IKS-----YLEIQKLRFGDR-LEVEIE 326

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491000781 415 EESLVPDCPnekqvtVLVTVLGNLIENA----LDAMSGQseGEVGLLLHYQNGWLSGEVSDDGPGIPPANIDAIFNKgFS 490
Cdd:COG2972  327 IDEELLDLL------IPKLILQPLVENAiehgIEPKEGG--GTIRISIRKEGDRLVITVEDNGVGMPEEKLEKLLEE-LS 397

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....
gi 491000781 491 TKGENRGVGLFLASQQLREL---GGTLAVESEPGVFTQFFVHLP 531
Cdd:COG2972  398 SKGEGRGIGLRNVRERLKLYygeEYGLEIESEPGEGTTVTIRIP 441
HATPase_CheA-like cd16916
Histidine kinase-like ATPase domain of the chemotaxis protein histidine kinase CheA, and some ...
 431-531 8.70e-09

Histidine kinase-like ATPase domain of the chemotaxis protein histidine kinase CheA, and some hybrid sensor histidine kinases; This family includes the cytoplasmic histidine kinase (HK) CheA, a transmembrane receptor which, together with cytoplasmic adaptor protein (CheW), forms the lattice at the core of the chemosensory array that controls the cellular chemotaxis of motile bacteria and archaea. CheA forms a two-component signal transduction system (TCS) with the response regulator CheY. Proteins having this CheA-like HATPase domain generally also have a histidine-phosphotransfer domain, a histidine kinase homodimeric domain, and a regulatory domain; some are hybrid sensor histidine kinases as they contain a REC signal receiver domain.


Pssm-ID: 340393 [Multi-domain]  Cd Length: 178  Bit Score: 55.28  E-value: 8.70e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491000781 431 LVTVLGNLIENALD----------AMSGQSEGEVGLLLHYQNGWLSGEVSDDGPGIPPANI------------------- 481
Cdd:cd16916   39 LADPLTHLLRNAVDhgieapeerlAAGKPPEGTITLRAEHQGNQVVIEVSDDGRGIDREKIrekaierglitadeaatls 118

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 491000781 482 -----DAIFNKGFSTKGE-----NRGVGLFLASQQLRELGGTLAVESEPGVFTQFFVHLP 531
Cdd:cd16916  119 ddevlNLIFAPGFSTAEQvtdvsGRGVGMDVVKRSIESLGGTIEVESEPGQGTTFTIRLP 178
PRK10490 PRK10490
sensor protein KdpD; Provisional
 434-531 2.97e-08

sensor protein KdpD; Provisional


Pssm-ID: 236701 [Multi-domain]  Cd Length: 895  Bit Score: 56.58  E-value: 2.97e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491000781 434 VLGNLIENALDAMSGQSEgeVGLLLHYQNGWLSGEVSDDGPGIPPANIDAIFNKgFStKGENR----GVGLFLA-SQQLR 508
Cdd:PRK10490 782 VLINLLENAVKYAGAQAE--IGIDAHVEGERLQLDVWDNGPGIPPGQEQLIFDK-FA-RGNKEsaipGVGLGLAiCRAIV 857

                         90       100
                 ....*....|....*....|....
gi 491000781 509 EL-GGTLAVESEPGVFTQFFVHLP 531
Cdd:PRK10490 858 EVhGGTIWAENRPEGGACFRVTLP 881
HATPase_AgrC-ComD-like cd16935
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 392-525 3.01e-08

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Staphylococcus aureus AgrC and Streptococcus pneumoniae ComD which are involved in quorum sensing; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) including Staphylococcus aureus AgrC which is an HK of the accessory gene regulator (agr) quorum sensing two-component regulatory system (TCS) AgrC-AgrA. The agr system plays a part in the transition from persistent to virulent phenotype. This family also includes Streptococcus pneumoniae ComD HK of the ComD-ComE TCS, involved in quorum sensing and genetic competence.


Pssm-ID: 340412 [Multi-domain]  Cd Length: 134  Bit Score: 52.58  E-value: 3.01e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491000781 392 VVAGFLIGKIQRAKERG--FTLNLAEESLVPDCPNEkqvtvLVTVLGNLIENALDAMSGQSEGE--VGLLLHYQNGWLSG 467
Cdd:cd16935    1 ALDSLLSEKLELAREKGieFTIEIDIPILLPISPLD-----LCIIFGNLLDNAIEACAKIDKENrfIHLKIRQKKGFLII 75

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 491000781 468 EVSDDGPGippaNIDAIFNKGFSTKGE-NRGVGLFLASQQLRELGGTLAVESEPGVFTQ 525
Cdd:cd16935   76 SIENSYEG----ELKKKNGLFLSTKKDkNHGIGLKSIREIVKKYNGNLSIEYENGIFTL 130
PRK13557 PRK13557
histidine kinase; Provisional
 344-536 8.37e-08

histidine kinase; Provisional


Pssm-ID: 237425 [Multi-domain]  Cd Length: 540  Bit Score: 54.68  E-value: 8.37e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491000781 344 SHEFMNKLHVILGLLNmksydkleeyVLQTAHTYQ-ADIGEIQ---HRIKSPVV-AGFLIGKI----QRAKERGFTLNL- 413
Cdd:PRK13557 171 AHDFNNLLQVMSGYLD----------VIQAALSHPdADRGRMArsvENIRAAAErAATLTQQLlafaRKQRLEGRVLNLn 240

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491000781 414 -------------------AEESLVPDCPN-EKQVTVLVTVLGNLIENALDAMSG------QSEG-EVGLL-LHYQNGWL 465
Cdd:PRK13557 241 glvsgmgelaertlgdavtIETDLAPDLWNcRIDPTQAEVALLNVLINARDAMPEggrvtiRTRNvEIEDEdLAMYHGLP 320

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491000781 466 SG-----EVSDDGPGIPPANIDAIFNKGFSTKGENRGVGLFL------ASQQlrelGGTLAVESEPGVFTQFFVHLPWDS 534
Cdd:PRK13557 321 PGryvsiAVTDTGSGMPPEILARVMDPFFTTKEEGKGTGLGLsmvygfAKQS----GGAVRIYSEVGEGTTVRLYFPASD 396


                 ..
gi 491000781 535 KR 536
Cdd:PRK13557 397 QA 398
HATPase_c_5 pfam14501
GHKL domain; This family represents the structurally related ATPase domains of histidine ...
 431-525 3.65e-07

GHKL domain; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.


Pssm-ID: 433996 [Multi-domain]  Cd Length: 102  Bit Score: 48.37  E-value: 3.65e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491000781  431 LVTVLGNLIENALDAMSGQSEG-EVGLLLHYQNGWLSGEVSDdgpgipPANIDAIFNKGF---STKGENRGVGLFLASQQ 506
Cdd:pfam14501   6 LCVIFGNLLDNAIEACSKIDDNrFIRLKIREKQNFLIIRIEN------TYEGELKFEGKLpstKTKGDGHGIGLKSIRRI 79

                          90
                  ....*....|....*....
gi 491000781  507 LRELGGTLAVESEPGVFTQ 525
Cdd:pfam14501  80 VKKYGGNLSTEIENGIFTL 98
PRK15347 PRK15347
two component system sensor kinase;
401-531 7.28e-07

two component system sensor kinase;


Pssm-ID: 237951 [Multi-domain]  Cd Length: 921  Bit Score: 52.34  E-value: 7.28e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491000781 401 IQ-RAKERGFTLnlaeESLV-PDCPNE--------KQVtvLVTVLGNlienaldAMSGQSEGEVGLLLHYQNGWLSGEVS 470
Cdd:PRK15347 484 IQgPAQSKSLTL----RTFVgAHVPLYlhldslrlRQI--LVNLLGN-------AVKFTETGGIRLRVKRHEQQLCFTVE 550

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 491000781 471 DDGPGIPPANIDAIFNKGFSTKGENRGVGLFL--ASQQLRELGGTLAVESEPGVFTQFFVHLP 531
Cdd:PRK15347 551 DTGCGIDIQQQQQIFTPFYQADTHSQGTGLGLtiASSLAKMMGGELTLFSTPGVGSCFSLVLP 613
SPOB_a pfam14689
Sensor_kinase_SpoOB-type, alpha-helical domain; Sporulation initiation phospho-transferase B ...
 337-370 9.31e-07

Sensor_kinase_SpoOB-type, alpha-helical domain; Sporulation initiation phospho-transferase B or SpoOB is part of a phospho-relay that initiates sporulation in Bacillus subtilis. Spo0B is a two-domain protein consisting of an N-terminal alpha-helical hairpin domain and a C-terminal alpha/beta domain. Two subunits of Spo0B dimerize by a parallel association of helical hairpins to form a novel four-helix bundle from which the active histidine - involved in the auto-phosphorylation - protrudes. In the phospho-relay, the signal-receptor histidine kinases are dephosphorylated by a common response regulator, Spo0F. Spo0B then takes phosphorylated Spo0F as substrate thereby mediating the transfer of a phosphoryl group to Spo0A, the ultimate transcription factor. The exact function of this alpha-helical domain is not known; it does not always occur just as the N-terminal domain of SPOB_ab, pfam14682. SCOP describes this domain as a histidine kinase-like fold lacking the kinase ATP-binding site.


Pssm-ID: 434130 [Multi-domain]  Cd Length: 62  Bit Score: 46.09  E-value: 9.31e-07
                          10        20        30
                  ....*....|....*....|....*....|....
gi 491000781  337 VDALRTTSHEFMNKLHVILGLLNMKSYDKLEEYV 370
Cdd:pfam14689  13 IKALRHQRHDFLNHLQVISGYLQLGRYDRAEEYI 46
nifL_nitrog TIGR02938
nitrogen fixation negative regulator NifL; NifL is a modulator of the nitrogen fixation ...
 438-520 1.21e-06

nitrogen fixation negative regulator NifL; NifL is a modulator of the nitrogen fixation positive regulator protein NifA, and is therefore a negative regulator. It binds NifA. NifA and NifL are encoded by adjacent genes. [Central intermediary metabolism, Nitrogen fixation, Regulatory functions, Protein interactions]


Pssm-ID: 131984 [Multi-domain]  Cd Length: 494  Bit Score: 51.06  E-value: 1.21e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491000781  438 LIENALDAMS--GQSEGEVGLLLHYQNGWLSGEVSDDGPGIPPANIDAIFNKGFSTKG---ENRGVGLFLASQQLRELGG 512
Cdd:TIGR02938 395 LVDNAIEAMNikGWKRRELSITTALNGDLIVVSILDSGPGIPQDLRYKVFEPFFTTKGgsrKHIGMGLSVAQEIVADHGG 474


                  ....*...
gi 491000781  513 TLAVESEP 520
Cdd:TIGR02938 475 IIDLDDDY 482
glnL PRK11073
nitrogen regulation protein NR(II);
230-531 1.63e-06

nitrogen regulation protein NR(II);


Pssm-ID: 182947 [Multi-domain]  Cd Length: 348  Bit Score: 50.08  E-value: 1.63e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491000781 230 MLHSLKEGVVAVDVEGRVTLINPAAsEILLSGPGKEIAHTPL----------LADLQEVLQTGEPIYDRELGC---NGFL 296
Cdd:PRK11073  12 ILNSLINSILLLDDDLAIHYANPAA-QQLLAQSSRKLFGTPLpellsyfslnIELMRESLQAGQGFTDNEVTLvidGRSH 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491000781 297 LISNTVPVRSQNAIVGAISTFRDKTEVSQLLQRLDGMVNYVDALRTTSHEFMNKLHVILG----LLNMKSYDKLEEY--- 369
Cdd:PRK11073  91 ILSLTAQRLPEGMILLEMAPMDNQRRLSQEQLQHAQQVAARDLVRGLAHEIKNPLGGLRGaaqlLSKALPDPALTEYtkv 170

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491000781 370 VLQtahtyQAD------------------IGEIQHRIKSPVVAGFLIGKIQRAK-ERGFTLNLAEESLVPDcpnekQVTv 430
Cdd:PRK11073 171 IIE-----QADrlrnlvdrllgpqrpgthVTESIHKVAERVVQLVSLELPDNVRlIRDYDPSLPELAHDPD-----QIE- 239

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491000781 431 lvTVLGNLIENALDAMsGQSEGEVGL--------LLHYQNGWLSG--EVSDDGPGIPPANIDAIFNKGFSTKGENRGVGL 500
Cdd:PRK11073 240 --QVLLNIVRNALQAL-GPEGGTITLrtrtafqlTLHGERYRLAAriDIEDNGPGIPPHLQDTLFYPMVSGREGGTGLGL 316

                        330       340       350
                 ....*....|....*....|....*....|.
gi 491000781 501 FLASQQLRELGGTLAVESEPGvFTQFFVHLP 531
Cdd:PRK11073 317 SIARNLIDQHSGKIEFTSWPG-HTEFSVYLP 346
PRK09303 PRK09303
histidine kinase;
434-531 2.92e-06

histidine kinase;


Pssm-ID: 236462 [Multi-domain]  Cd Length: 380  Bit Score: 49.56  E-value: 2.92e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491000781 434 VLGNLIENALDAMsgQSEGEVGL-LLHYQNGWLSGEVSDDGPGIPPANIDAIFNKGF----STKGENRGVGLFLASQQLR 508
Cdd:PRK09303 276 VLLNLLDNAIKYT--PEGGTITLsMLHRTTQKVQVSICDTGPGIPEEEQERIFEDRVrlprDEGTEGYGIGLSVCRRIVR 353

                         90       100
                 ....*....|....*....|...
gi 491000781 509 ELGGTLAVESEPGVFTQFFVHLP 531
Cdd:PRK09303 354 VHYGQIWVDSEPGQGSCFHFTLP 376
HATPase_EnvZ-like cd16950
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 434-514 2.93e-06

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli EnvZ and Pseudomonas aeruginosa BfmS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli EnvZ of the EnvZ-OmpR two-component regulatory system (TCS), which functions in osmoregulation. It also contains the HATPase domain of Pseudomonas aeruginosa BfmS, the HK of the BfmSR TCS, which functions in the regulation of the rhl quorum-sensing system and bacterial virulence in P. aeruginosa. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a periplasmic domain.


Pssm-ID: 340426 [Multi-domain]  Cd Length: 101  Bit Score: 45.90  E-value: 2.93e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491000781 434 VLGNLIENALDAMSG----QSEGEVGLLlhyqngWLSgeVSDDGPGIPPANIDAIFN---KGFSTKG-ENRGVGLFLASQ 505
Cdd:cd16950    4 VLSNLVDNALRYGGGwvevSSDGEGNRT------RIQ--VLDNGPGIAPEEVDELFQpfyRGDNARGtSGTGLGLAIVQR 75


                 ....*....
gi 491000781 506 QLRELGGTL 514
Cdd:cd16950   76 ISDAHGGSL 84
CheA COG0643
Chemotaxis protein histidine kinase CheA [Signal transduction mechanisms];
468-531 6.77e-06

Chemotaxis protein histidine kinase CheA [Signal transduction mechanisms];


Pssm-ID: 440408 [Multi-domain]  Cd Length: 563  Bit Score: 48.64  E-value: 6.77e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491000781 468 EVSDDGPGIPPANI-------------------DA-----IFNKGFSTKGE-----NRGVGLFLASQQLRELGGTLAVES 518
Cdd:COG0643  325 EVSDDGRGLDLEKIrakaiekglitaeeaaalsDEellelIFAPGFSTAEEvtdlsGRGVGMDVVKTNIEALGGTIEIES 404

                         90
                 ....*....|...
gi 491000781 519 EPGVFTQFFVHLP 531
Cdd:COG0643  405 EPGKGTTFTLRLP 417
COG3920 COG3920
Two-component sensor histidine kinase, HisKA and HATPase domains [Signal transduction ...
 271-536 8.40e-06

Two-component sensor histidine kinase, HisKA and HATPase domains [Signal transduction mechanisms];


Pssm-ID: 443125 [Multi-domain]  Cd Length: 495  Bit Score: 48.36  E-value: 8.40e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491000781 271 LLADLQEVLQTGEPIYDRELGCNGFLLISNTVPVRSQNAIVGAISTFRDKTEVSQLLQRLDGMVNYVDAL-RTTSHEFMN 349
Cdd:COG3920  229 ALLRLRAAVLEELERRRRARGLGRLLLLLLLLLLLLRALLLLAAGIRLVITERKRAEEELEASLEEKELLlRELHHRVKN 308

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491000781 350 KLHVILGLLNMKS-------------------------YDKLeeyvLQTAHTYQADIGEIQHRIKSPVVAGFLIGKIQra 404
Cdd:COG3920  309 NLQVVSSLLRLQArraddpearealeesqnriqalalvHELL----YQSEDWEGVDLRDYLRELLEPLRDSYGGRGIR-- 382

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491000781 405 kergFTLNLAEESLVPDcpnekQVTVLVTVLGNLIENALD-AMSGQSEGEVGLLLHYQNGWLSGEVSDDGPGIPPaNIDA 483
Cdd:COG3920  383 ----IELDGPDVELPAD-----AAVPLGLILNELVTNALKhAFLSGEGGRIRVSWRREDGRLRLTVSDNGVGLPE-DVDP 452

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|...
gi 491000781 484 ifnkgfstkGENRGVGLFLASQQLRELGGTLAVESEPGvfTQFFVHLPWDSKR 536
Cdd:COG3920  453 ---------PARKGLGLRLIRALVRQLGGTLELDRPEG--TRVRITFPLAELA 494
PAS COG2202
PAS domain [Signal transduction mechanisms];
228-330 1.70e-05

PAS domain [Signal transduction mechanisms];


Pssm-ID: 441804 [Multi-domain]  Cd Length: 258  Bit Score: 46.56  E-value: 1.70e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491000781 228 QAMLHSLKEGVVAVDVEGRVTLINPAASEILLSGPGKEIAHTP-----------LLADLQEVLQTGEPIYDREL-----G 291
Cdd:COG2202  140 RLLVENAPDGIFVLDLDGRILYVNPAAEELLGYSPEELLGKSLldllhpedrerLLELLRRLLEGGRESYELELrlkdgD 219

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 491000781 292 CNGFLLISNTVPVRSQNAIVGAISTFRDKTEVSQLLQRL 330
Cdd:COG2202  220 GRWVWVEASAVPLRDGGEVIGVLGIVRDITERKRAEEAL 258
RsbW COG2172
Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms];
425-521 1.77e-05

Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms];


Pssm-ID: 441775 [Multi-domain]  Cd Length: 127  Bit Score: 44.52  E-value: 1.77e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491000781 425 EKQVTVLVTVLGNLIENALD-AMSGQSEGEVGLLLHYQNGWLSGEVSDDGPGIPPANIDaifnKGFSTKGEnRGVGLFLA 503
Cdd:COG2172   29 EDDADDLVLAVSEAVTNAVRhAYGGDPDGPVEVELELDPDGLEIEVRDEGPGFDPEDLP----DPYSTLAE-GGRGLFLI 103

                         90
                 ....*....|....*...
gi 491000781 504 SQQLRELGgtlaVESEPG 521
Cdd:COG2172  104 RRLMDEVE----YESDPG 117
PRK11466 PRK11466
hybrid sensory histidine kinase TorS; Provisional
 468-531 1.82e-05

hybrid sensory histidine kinase TorS; Provisional


Pssm-ID: 236914 [Multi-domain]  Cd Length: 914  Bit Score: 47.59  E-value: 1.82e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 491000781 468 EVSDDGPGIPPANIDAIFNKGFSTKGENRGVGLFLA-SQQLRE-LGGTLAVESEPGVFTQFFVHLP 531
Cdd:PRK11466 596 EVEDSGCGIDPAKLAEIFQPFVQVSGKRGGTGLGLTiSSRLAQaMGGELSATSTPEVGSCFCLRLP 661
HATPase_CreC-like cd16945
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 435-521 2.44e-05

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CreC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli CreC of the CreC-CreB two-component regulatory system (TCS) involved in catabolic regulation. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and accessory sensory domain(s) such as HAMP, CACHE or PAS.


Pssm-ID: 340421 [Multi-domain]  Cd Length: 106  Bit Score: 43.60  E-value: 2.44e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491000781 435 LGNLIENALDAMSgqSEGEVGLLLHYQNGWLSGEVSDDGPGIPPANIDAIFNKGFS-----TKGENRGVGLFLASQQLRE 509
Cdd:cd16945    9 INNLLDNAIDFSP--EGGLIALQLEADTEGIELLVFDEGSGIPDYALNRVFERFYSlprphSGQKSTGLGLAFVQEVAQL 86

                         90
                 ....*....|..
gi 491000781 510 LGGTLAVESEPG 521
Cdd:cd16945   87 HGGRITLRNRPD 98
HATPase_YcbM-like cd16947
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 419-530 2.52e-05

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis YcbM; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis YcbM, a HK of the two-component system YcbM-YcbL. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA).


Pssm-ID: 340423 [Multi-domain]  Cd Length: 125  Bit Score: 44.04  E-value: 2.52e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491000781 419 VPDCPNEKQVT--VLVTVLGNLIENALDamSGQSEGEVGLLLHYQNGWLSGEVSDDGPGIPPANIDAIFNKGFsTKGENR 496
Cdd:cd16947    7 IPDRPIYANANteALQRILKNLISNAIK--YGSDGKFLGMTLREDEKHVYIDIWDKGKGISETEKDHVFERLY-TLEDSR 83

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 491000781 497 -------GVGLFLASQQLRELGGTLAVESEPGVFTQFFVHL 530
Cdd:cd16947   84 nsakqgnGLGLTITKRLAESMGGSIYVNSKPYEKTVFTVTL 124
PRK11100 PRK11100
sensory histidine kinase CreC; Provisional
 435-521 3.00e-05

sensory histidine kinase CreC; Provisional


Pssm-ID: 236846 [Multi-domain]  Cd Length: 475  Bit Score: 46.76  E-value: 3.00e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491000781 435 LGNLIENALD-AMSGqseGEVGLLLHYQNGWLSGEVSDDGPGIPPANIDAIFNKGFS-----TKGENRGVGLFLASQQLR 508
Cdd:PRK11100 373 LGNLLDNAIDfSPEG---GTITLSAEVDGEQVALSVEDQGPGIPDYALPRIFERFYSlprpaNGRKSTGLGLAFVREVAR 449

                         90
                 ....*....|...
gi 491000781 509 ELGGTLAVESEPG 521
Cdd:PRK11100 450 LHGGEVTLRNRPE 462
PRK11091 PRK11091
aerobic respiration control sensor protein ArcB; Provisional
 429-531 9.02e-05

aerobic respiration control sensor protein ArcB; Provisional


Pssm-ID: 236842 [Multi-domain]  Cd Length: 779  Bit Score: 45.32  E-value: 9.02e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491000781 429 TVLVTVLGNLIENAldaMSGQSEGEVGLLLHYQNG-WLSGEVSDDGPGIPPANIDAIFNKGFSTKGEN-------RGVGL 500
Cdd:PRK11091 397 TRLRQILWNLISNA---VKFTQQGGVTVRVRYEEGdMLTFEVEDSGIGIPEDELDKIFAMYYQVKDSHggkpatgTGIGL 473

                         90       100       110
                 ....*....|....*....|....*....|.
gi 491000781 501 FLASQQLRELGGTLAVESEPGVFTQFFVHLP 531
Cdd:PRK11091 474 AVSKRLAQAMGGDITVTSEEGKGSCFTLTIH 504
PAS pfam00989
PAS fold; The PAS fold corresponds to the structural domain that has previously been defined ...
 225-319 9.56e-05

PAS fold; The PAS fold corresponds to the structural domain that has previously been defined as PAS and PAC motifs. The PAS fold appears in archaea, eubacteria and eukarya. This domain can bind gases (O2, CO and NO), FAD, 4-hydroxycinnamic acid and NAD+ (Matilla et.al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).


Pssm-ID: 395786 [Multi-domain]  Cd Length: 113  Bit Score: 42.02  E-value: 9.56e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491000781  225 QQRQAMLHSLKEGVVAVDVEGRVTLINPAAsEILLSGPGKEIAHTPLLAD------------LQEVLQTGEP---IYDRE 289
Cdd:pfam00989   1 EDLRAILESLPDGIFVVDEDGRILYVNAAA-EELLGLSREEVIGKSLLDLipeeddaevaelLRQALLQGEEsrgFEVSF 79

                          90       100       110
                  ....*....|....*....|....*....|...
gi 491000781  290 LGCNG--FLLISNTVPVRS-QNAIVGAISTFRD 319
Cdd:pfam00989  80 RVPDGrpRHVEVRASPVRDaGGEILGFLGVLRD 112
ComP COG4585
Signal transduction histidine kinase ComP [Signal transduction mechanisms];
453-535 9.90e-05

Signal transduction histidine kinase ComP [Signal transduction mechanisms];


Pssm-ID: 443642 [Multi-domain]  Cd Length: 252  Bit Score: 44.22  E-value: 9.90e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491000781 453 EVGLLLHYQNGWLSGEVSDDGPGIPPANIDAifnkgfstkgenRGVGLFLASQQLRELGGTLAVESEPGVFTQFFVHLPW 532
Cdd:COG4585  182 RVTVTLEVDDGELTLTVRDDGVGFDPEAAPG------------GGLGLRGMRERAEALGGTLTIGSAPGGGTRVRATLPL 249


                 ...
gi 491000781 533 DSK 535
Cdd:COG4585  250 AAA 252
PRK10604 PRK10604
sensor protein RstB; Provisional
 434-520 1.23e-04

sensor protein RstB; Provisional


Pssm-ID: 236724 [Multi-domain]  Cd Length: 433  Bit Score: 44.59  E-value: 1.23e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491000781 434 VLGNLIENALDAMSGQSEgeVGLLLHYQNGWLsgEVSDDGPGIPPANIDAIF--------NKGFSTKGenRGVGLFLASQ 505
Cdd:PRK10604 323 VLDNLLNNALRYAHSRVR--VSLLLDGNQACL--IVEDDGPGIPPEERERVFepfvrldpSRDRATGG--CGLGLAIVHS 396

                         90
                 ....*....|....*
gi 491000781 506 QLRELGGTLAVESEP 520
Cdd:PRK10604 397 IALAMGGSVNCDESE 411
HATPase_TutC-TodS-like cd16925
Histidine kinase-like ATPase domain of hybrid sensor histidine kinases similar to Pseudomonas ...
 469-531 2.12e-04

Histidine kinase-like ATPase domain of hybrid sensor histidine kinases similar to Pseudomonas putida TodS and Thauera aromatica TutC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinase (HKs) such Pseudomonas putida TodS HK of the TodS-TodT two-component regulatory system (TCS) which controls the expression of a toluene degradation pathway. Thauera aromatica TutC may be part of a TCS that is involved in anaerobic toluene metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), PAS sensor domain(s) and a REC domain.


Pssm-ID: 340402 [Multi-domain]  Cd Length: 110  Bit Score: 40.94  E-value: 2.12e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 491000781 469 VSDDGPGIPPANIDAIFNK----GFSTKGENRGVGLFLA-SQQLREL-GGTLAVESEPGVFTQFFVHLP 531
Cdd:cd16925   42 VSDSGPGIPPNLREEIFERfrqgDGSSTRAHGGTGLGLSiVKEFVELhGGTVTVSDAPGGGALFQVELP 110
COG4192 COG4192
Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal ...
 403-518 2.52e-04

Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal transduction mechanisms];


Pssm-ID: 443346 [Multi-domain]  Cd Length: 640  Bit Score: 43.91  E-value: 2.52e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491000781 403 RAKERGFTLNLAEESLVPDCPnekqvTVLVTVLGNLIENALDAMSGQSEGEVGLLLhyQNGWLSGEVSDDGPGIPPAniD 482
Cdd:COG4192  521 RAKPQQITLHIPDDLMVQGDQ-----VLLEQVLVNLLVNALDAVATQPQISVDLLS--NAENLRVAISDNGNGWPLV--D 591

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 491000781 483 AIFNKGFSTKGENRGVGLFLASQQLRELGGTLAVES 518
Cdd:COG4192  592 KLFTPFTTTKEVGLGLGLSICRSIMQQFGGDLYLAS 627
HATPase_NtrY-like cd16944
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 434-521 2.54e-04

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Azorhizobium caulinodans NtrY; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Azorhizobium caulinodans ORS571 NtrY of the NtrY-NtrX TCS, which is involved in nitrogen fixation and metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also have PAS sensor domains.


Pssm-ID: 340420 [Multi-domain]  Cd Length: 108  Bit Score: 40.60  E-value: 2.54e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491000781 434 VLGNLIENALDAMSGQSE--GEVGLLLHY-QNGWLSGEVSDDGPGIPPANIDAIFNKGFSTKGENRGVGLFLASQQLREL 510
Cdd:cd16944    8 VLTNILKNAAEAIEGRPSdvGEVRIRVEAdQDGRIVLIVCDNGKGFPREMRHRATEPYVTTRPKGTGLGLAIVKKIMEEH 87

                         90
                 ....*....|.
gi 491000781 511 GGTLAVESEPG 521
Cdd:cd16944   88 GGRISLSNREA 98
HATPase_FilI-like cd16921
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 431-531 3.32e-04

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Methanosaeta harundinacea FilI and some hybrid sensor histidine kinases; This family includes FilI, the histidine kinase (HK) component of FilI-FilRs, a two-component signal transduction system (TCS) of the methanogenic archaeon, Methanosaeta harundinacea, which is involved in regulating methanogenesis. The cytoplasmic HK core consists of a C-terminal HK-like ATPase domain (represented here) and a histidine kinase dimerization and phosphoacceptor domain (HisKA) domain, which, in FilI, are coupled to CHASE, HAMP, PAS, and GAF sensor domains. FilI-FilRs catalyzes the phosphotransfer between FilI (HK) and FilRs (FilR1 and FilR2, response regulators) of the TCS. TCSs are predicted to be of bacterial origin, and acquired by archaea by horizontal gene transfer. This model also includes related HATPase domains such as that of Synechocystis sp. PCC6803 phytochrome-like protein Cph1. Proteins having this HATPase domain and HisKA domain also have accessory sensor domains such as CHASE, GAF, HAMP and PAS; some are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.


Pssm-ID: 340398 [Multi-domain]  Cd Length: 105  Bit Score: 40.00  E-value: 3.32e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491000781 431 LVTVLGNLIENALDAMSGQSEGEVGLllHYQ---NGWLSgEVSDDGPGIPP---ANIDAIFNKGFS-TKGENRGVGLFLA 503
Cdd:cd16921    1 LGQVLTNLLGNAIKFRRPRRPPRIEV--GAEdvgEEWTF-YVRDNGIGIDPeyaEKVFGIFQRLHSrEEYEGTGVGLAIV 77

                         90       100
                 ....*....|....*....|....*...
gi 491000781 504 SQQLRELGGTLAVESEPGVFTQFFVHLP 531
Cdd:cd16921   78 RKIIERHGGRIWLESEPGEGTTFYFTLP 105
PAS smart00091
PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising ...
 225-282 4.26e-04

PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels.


Pssm-ID: 214512  Cd Length: 67  Bit Score: 38.92  E-value: 4.26e-04
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 491000781   225 QQRQAMLHSLKEGVVAVDVEGRVTLINPAASEIL-------LSGPGKEIAHTPLLADLQEVLQTG 282
Cdd:smart00091   1 ERLRAILESLPDGIFVLDLDGRILYANPAAEELLgyspeelIGKSLLELIHPEDRERVQEALQRL 65
HATPase_CpxA-like cd16949
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 437-521 6.06e-04

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CpxA; This family includes the histidine kinase-like ATPase (HATPase) domains of two-component sensor histidine kinase (HKs) similar to Escherichia coli CpxA, HK of the CpxA-CpxR two-component regulatory system (TCS) which may function in acid stress and in cell wall stability. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a CpxA family periplasmic domain.


Pssm-ID: 340425 [Multi-domain]  Cd Length: 104  Bit Score: 39.23  E-value: 6.06e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491000781 437 NLIENALDamsgQSEGEVGLLLHYQNGWLSGEVSDDGPGIPPANIDAIFNKGF------STKGENRGVGLFLASQQLREL 510
Cdd:cd16949    7 NVLRNALR----YSPSKILLDISQDGDQWTITITDDGPGVPEDQLEQIFLPFYrvdsarDRESGGTGLGLAIAERAIEQH 82

                         90
                 ....*....|..
gi 491000781 511 GGTL-AVESEPG 521
Cdd:cd16949   83 GGKIkASNRKPG 94
HATPase_RstB-like cd16939
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 434-531 7.54e-04

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Salmonella typhimurium RstB; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Salmonella typhimurium RstB HK of the RstA-RstB two-component regulatory system (TCS), which regulates expression of the constituents participating in pyrimidine metabolism and iron acquisition, and may be required for regulation of Salmonella motility and invasion. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensor domain.


Pssm-ID: 340416 [Multi-domain]  Cd Length: 104  Bit Score: 38.95  E-value: 7.54e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491000781 434 VLGNLIENALdaMSGQSEGEVGLLLhyQNGWLSGEVSDDGPGIPPANIDAIF--------NKGFSTKGenRGVGLFLASQ 505
Cdd:cd16939    4 ALDNLLRNAL--RYAHRTVRIALLV--SGGRLTLIVEDDGPGIPAAARERVFepfvrldpSRDRATGG--FGLGLAIVHR 77

                         90       100
                 ....*....|....*....|....*.
gi 491000781 506 QLRELGGTLAVESEPGVFTQFFVHLP 531
Cdd:cd16939   78 VALWHGGHVECDDSELGGACFRLTWP 103
PAS_4 pfam08448
PAS fold; The PAS fold corresponds to the structural domain that has previously been defined ...
 231-325 8.54e-04

PAS fold; The PAS fold corresponds to the structural domain that has previously been defined as PAS and PAC motifs. The PAS fold appears in archaea, eubacteria and eukarya. This domain is associated to signalling systems and works as a signal sensor domain. It recognizes differently substituted aromatic hydrocarbons, oxygen, different dodecanoic acids, autoinducers, 3,5-dimethyl-pyrazin-2-ol and N-alanyl-aminoacetone (Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).


Pssm-ID: 312075 [Multi-domain]  Cd Length: 110  Bit Score: 38.93  E-value: 8.54e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491000781  231 LHSLKEGVVAVDVEGRVTLINPAASEILLSGP----GK-------EIAHTPLLADLQEVLQTGEPIYD-RELGCNGFL-- 296
Cdd:pfam08448   1 LDSLPDALAVLDPDGRVRYANAAAAELFGLPPeellGKtlaellpPEDAARLERALRRALEGEEPIDFlEELLLNGEErh 80

                          90       100       110
                  ....*....|....*....|....*....|
gi 491000781  297 LISNTVPVR-SQNAIVGAISTFRDKTEVSQ 325
Cdd:pfam08448  81 YELRLTPLRdPDGEVIGVLVISRDITERRR 110
PAS COG2202
PAS domain [Signal transduction mechanisms];
216-330 8.57e-04

PAS domain [Signal transduction mechanisms];


Pssm-ID: 441804 [Multi-domain]  Cd Length: 258  Bit Score: 41.16  E-value: 8.57e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491000781 216 EPQEISTQFQQRQAMLHSLKEGVVAVDVEGRVTLINPAASEI-------LLSGPGKEIAHTPLLADLQEVLQ---TGEPI 285
Cdd:COG2202    2 AEEALEESERRLRALVESSPDAIIITDLDGRILYVNPAFERLtgysaeeLLGKTLRDLLPPEDDDEFLELLRaalAGGGV 81

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 491000781 286 YDRELGC---NG--FLLISNTVPVR-SQNAIVGAISTFRDKTEVSQLLQRL 330
Cdd:COG2202   82 WRGELRNrrkDGslFWVELSISPVRdEDGEITGFVGIARDITERKRAEEAL 132
envZ PRK09467
osmolarity sensor protein; Provisional
 434-503 9.97e-04

osmolarity sensor protein; Provisional


Pssm-ID: 236531 [Multi-domain]  Cd Length: 435  Bit Score: 41.82  E-value: 9.97e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491000781 434 VLGNLIENALdamsgqsegevglllHYQNGWL---SG--------EVSDDGPGIPPANIDAIFnKGFsTKGE----NRGV 498
Cdd:PRK09467 335 ALANLVVNAA---------------RYGNGWIkvsSGtegkrawfQVEDDGPGIPPEQLKHLF-QPF-TRGDsargSSGT 397


                 ....*
gi 491000781 499 GLFLA 503
Cdd:PRK09467 398 GLGLA 402
HATPase_c_3 pfam13589
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents, additionally, ...
 431-504 1.17e-03

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents, additionally, the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.


Pssm-ID: 433332 [Multi-domain]  Cd Length: 135  Bit Score: 39.24  E-value: 1.17e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491000781  431 LVTVLGNLIENALDAMSGQsegeVGLLLHYQNGWLSG-EVSDDGPGIPPANIDAIFNKGFSTK----GEN----RGVGLF 501
Cdd:pfam13589   1 LEGALAELIDNSIDADATN----IKIEVNKNRGGGTEiVIEDDGHGMSPEELINALRLATSAKeakrGSTdlgrYGIGLK 76


                  ...
gi 491000781  502 LAS 504
Cdd:pfam13589  77 LAS 79
HATPase_EL346-LOV-HK-like cd16951
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 381-477 1.35e-03

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Erythrobacter litoralis blue light-activated histidine kinase 2; This domain family includes the histidine kinase-like ATPase (HATPase) domain of blue light-activated histidine kinase 2 of Erythrobacter litoralis (EL346). Signaling commonly occurs within HK dimers, however EL346 functions as a monomer. Also included in this family are the HATPase domains of ethanolamine utilization sensory transduction histidine kinase (EutW), whereby regulation of ethanolamine, a carbon and nitrogen source for gut bacteria, results in autophosphorylation and subsequent phosphoryl transfer to a response regulator (EutV) containing an RNA-binding domain. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have an accessory PAS sensor domain, while some have an N-terminal histidine kinase domain.


Pssm-ID: 340427 [Multi-domain]  Cd Length: 131  Bit Score: 38.94  E-value: 1.35e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491000781 381 IGEIQHRIKSPVVAGFLIGKIqrakergfTLNLAEESLvpDCPNEKqVTVLVTVLGNLIENALD-AMSGQSEGEVGLLLH 459
Cdd:cd16951    1 LGEYINRIASAINAIHAVGDI--------RINITGDTG--PVSSEV-ATAIGLVVNELLQNALKhAFSDREGGTITIRSV 69

                         90
                 ....*....|....*...
gi 491000781 460 YQNGWLSGEVSDDGPGIP 477
Cdd:cd16951   70 VDGDYLRITVIDDGVGLP 87
HATPase_PDK-like cd16929
Histidine kinase-like ATPase domain of pyruvate dehydrogenase kinase, branched-chain ...
 464-531 2.92e-03

Histidine kinase-like ATPase domain of pyruvate dehydrogenase kinase, branched-chain alpha-ketoacid dehydrogenase kinase and related domains; This family includes the histidine kinase-like ATPase (HATPase) domains of all four PDK isoforms (pyruvate dehydrogenase kinases 1-4) that have been described in mammals, and other PDKs including Saccharomyces Pkp1p and Pkp2p. PDKs and phosphatases tightly regulate the mitochondrial pyruvate dehydrogenase complex (PDC) by reversible phosphorylation. PDC catalyzes the oxidative decarboxylation of pyruvate to acetyl-CoA, connecting glycolysis and the TCA acid cycle. Also included in this family is mammalian branched-chain alpha-ketoacid dehydrogenase kinase (BDK), a mitochondrial protein kinase that phosphorylates a subunit of the branched-chain a-ketoacid dehydrogenase (BCKD) complex, which catalyzes the oxidative decarboxylation of branched-chain alpha-ketoacids derived from leucine, isoleucine, and valine, a rate-limiting step in the oxidative degradation of these branched-chain amino acids.


Pssm-ID: 340406 [Multi-domain]  Cd Length: 169  Bit Score: 38.86  E-value: 2.92e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491000781 464 WLSGEVSDDGPGIPPANIDAIFNKGFST-------------KGENR------GVGLFLASQQLRELGGTLAVESEPGVFT 524
Cdd:cd16929   83 DLTIKISDRGGGIPREDLARLFSYMYSTapqpslddfsdliSGTQPsplagfGYGLPMSRLYAEYFGGDLDLQSMEGYGT 162


                 ....*..
gi 491000781 525 QFFVHLP 531
Cdd:cd16929  163 DVYIYLK 169
PRK09959 PRK09959
acid-sensing system histidine kinase EvgS;
434-531 3.57e-03

acid-sensing system histidine kinase EvgS;


Pssm-ID: 182169 [Multi-domain]  Cd Length: 1197  Bit Score: 40.49  E-value: 3.57e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491000781  434 VLGNLIENALDAMSgqsEGEVGL---LLHYQN--GWLSGEVSDDGPGIPPANIDAIFnKGFSTKGENR-----GVGLFLA 503
Cdd:PRK09959  832 VLSNLLSNALKFTT---EGAVKIttsLGHIDDnhAVIKMTIMDSGSGLSQEEQQQLF-KRYSQTSAGRqqtgsGLGLMIC 907

                          90       100
                  ....*....|....*....|....*...
gi 491000781  504 SQQLRELGGTLAVESEPGVFTQFFVHLP 531
Cdd:PRK09959  908 KELIKNMQGDLSLESHPGIGTTFTITIP 935
TyrR COG3283
Transcriptional regulator TyrR of aromatic amino acids metabolism [Transcription, Amino acid ...
 228-258 3.64e-03

Transcriptional regulator TyrR of aromatic amino acids metabolism [Transcription, Amino acid transport and metabolism];


Pssm-ID: 442513 [Multi-domain]  Cd Length: 514  Bit Score: 39.79  E-value: 3.64e-03
                         10        20        30
                 ....*....|....*....|....*....|.
gi 491000781 228 QAMLHSLKEGVVAVDVEGRVTLINPAASEIL 258
Cdd:COG3283   83 DALLEALPDPVFSIDLKGKIELANPAALSLL 113
PRK04184 PRK04184
DNA topoisomerase VI subunit B; Validated
 431-487 5.49e-03

DNA topoisomerase VI subunit B; Validated


Pssm-ID: 235246 [Multi-domain]  Cd Length: 535  Bit Score: 39.49  E-value: 5.49e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 491000781 431 LVTVLGNLIENALDAmsgqSEgEVGLL---------LHYQNGWLSGEVSDDGPGIPPANIDAIFNK 487
Cdd:PRK04184  37 LYTTVKELVDNSLDA----CE-EAGILpdikieikrVDEGKDHYRVTVEDNGPGIPPEEIPKVFGK 97
HATPase_UhpB-NarQ-NarX-like cd16917
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 458-531 5.84e-03

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli UhpB, NarQ and NarX, and Bacillus subtilis YdfH, YhcY and YfiJ; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Escherichia coli UhpB, a HK of the UhpB-UhpA TCS, NarQ and NarX, HKs of the NarQ-NarP and NarX-NarL TCSs, respectively, and Bacillus YdfH, YhcY and YfiJ HKs, of the YdfH-YdfI, YhcY-YhcZ and YfiJ-YfiK TCSs, respectively. In addition, it includes Bacillus YxjM, ComP, LiaS and DesK, HKs of the YxjM-YxjML, ComP-ComA, LiaS-LiaR, DesR-DesK TCSs, respectively. Proteins having this HATPase domain have a histidine kinase dimerization and phosphoacceptor domain; some have accessory domains such as GAF, HAMP, PAS and MASE sensor domains.


Pssm-ID: 340394 [Multi-domain]  Cd Length: 87  Bit Score: 35.99  E-value: 5.84e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 491000781 458 LHYQNGWLSGEVSDDGPGIPPAnidaifnkgfsTKGENRGVGLFLASQQLRELGGTLAVESEPGVFTQFFVHLP 531
Cdd:cd16917   25 LSYTADELTLTVVDDGVGFDGP-----------APPGGGGFGLLGMRERAELLGGTLTIGSRPGGGTRVTARLP 87
PRK10815 PRK10815
two-component system sensor histidine kinase PhoQ;
431-520 5.86e-03

two-component system sensor histidine kinase PhoQ;


Pssm-ID: 182754 [Multi-domain]  Cd Length: 485  Bit Score: 39.23  E-value: 5.86e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491000781 431 LVTVLGNLIENA-------LDAMSGQSEGEVGLLlhyqngwlsgeVSDDGPGIPPANIDAIFNKG--FSTKGENRGVGLF 501
Cdd:PRK10815 379 FMEVMGNVLDNAckyclefVEISARQTDEHLHIV-----------VEDDGPGIPESKRELIFDRGqrADTLRPGQGLGLS 447

                         90
                 ....*....|....*....
gi 491000781 502 LASQQLRELGGTLAVESEP 520
Cdd:PRK10815 448 VAREITEQYEGKISAGDSP 466
sensory_box TIGR00229
PAS domain S-box; The PAS domain was previously described. This sensory box, or S-box domain ...
 229-330 6.88e-03

PAS domain S-box; The PAS domain was previously described. This sensory box, or S-box domain occupies the central portion of the PAS domain but is more widely distributed. It is often tandemly repeated. Known prosthetic groups bound in the S-box domain include heme in the oxygen sensor FixL, FAD in the redox potential sensor NifL, and a 4-hydroxycinnamyl chromophore in photoactive yellow protein. Proteins containing the domain often contain other regulatory domains such as response regulator or sensor histidine kinase domains. Other S-box proteins include phytochromes and the aryl hydrocarbon receptor nuclear translocator. [Regulatory functions, Small molecule interactions]


Pssm-ID: 272971 [Multi-domain]  Cd Length: 124  Bit Score: 36.89  E-value: 6.88e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 491000781  229 AMLHSLKEGVVAVDVEGRVTLINPAASEI-------LLSGPGKEIAHTPLLADLQEVLQ---TGEP---IYDRELGC-NG 294
Cdd:TIGR00229   7 AIFESSPDAIIVIDLEGNILYVNPAFEEIfgysaeeLIGRNVLELIPEEDREEVRERIErrlEGEPepvSEERRVRRkDG 86

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 491000781  295 --FLLISNTVPVRSQNAIVGAISTFRDKTEVSQLLQRL 330
Cdd:TIGR00229  87 seIWVEVSVSPIRTNGGELGVVGIVRDITERKEAEEAL 124
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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