|
Name |
Accession |
Description |
Interval |
E-value |
| PRK07561 |
PRK07561 |
DNA topoisomerase I subunit omega; Validated |
2-849 |
0e+00 |
|
DNA topoisomerase I subunit omega; Validated
Pssm-ID: 236048 [Multi-domain] Cd Length: 859 Bit Score: 1529.34 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490999310 2 GKALVIVESPAKAKTINKYLGNDYVVKSSVGHIRDLPTSGSASKKSADStstkgakkpkkdersALVNRMGVDPWHDWDA 81
Cdd:PRK07561 1 GKSLVIVESPAKAKTINKYLGSDYVVKASVGHIRDLPTSASSVPAKEKG---------------ALWARMGVDPDHDFEA 65
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490999310 82 QYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIAWHLREVIGGDEKRYSRVVFNEITKNAIRQAFDKPGELNIDR 161
Cdd:PRK07561 66 LYEVLPGKEKVVSELKKAAKDADELYLATDPDREGEAIAWHLLEVLGGDDVPVKRVVFNEITKNAIQEAFENPRELDINL 145
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490999310 162 VNAQQARRFMDRVVGYMVSPLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEIDASTTTPGGDALPLQVTHK 241
Cdd:PRK07561 146 VNAQQARRFLDRLVGYMVSPLLWKKIARGLSAGRVQSVAVRLIVEREREIEAFVPEEYWDIHADLTTPRGDAFEARLTHL 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490999310 242 HDKPFRPV---NRDETMAAVALLEKASYSVLEREDKPTSSKPGAPFITSTLQQAASTRLGFGVKKTMMMAQRLYEAGYIT 318
Cdd:PRK07561 226 DGKKFAPVdllNEAQAEAAVAALEGARYSVASVEDKPTTRKPSAPFTTSTLQQEASRKLGFSVKKTMRIAQRLYEAGYIT 305
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490999310 319 YMRTDSTNLSQDALSMVRGYIGDNFGKKYLPENANQYASK-ENSQEAHEAIRPSDVNVMAEDLKGMEADALKLYQLIWRQ 397
Cdd:PRK07561 306 YMRTDSTNLSQEAINAARGYIGDNYGKKYLPEKPRQYSSKaKNAQEAHEAIRPSDVFRTPDQLKGLEGDAQRLYELIWKR 385
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490999310 398 FVACQMTPAQYDSTTLTVKAGDFKLKARGRTLRFDGWTKVMPALRKG---DEDRTLPVVNQGESLSLVELTPAQHFTKPP 474
Cdd:PRK07561 386 FVASQMAPARYDSTTVTIAAGDAELRATGRVLRFDGFLKVYVEGRDDaldDEDRRLPALKVGDALTLEKLDPTQHFTKPP 465
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490999310 475 ARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRRFYAEKMGEIVTDRLEENFRDLMNYDFTAQMEDRLDQVA 554
Cdd:PRK07561 466 ARYSEASLVKELEKLGIGRPSTYASIISTIQDRGYVRLENRRFYPEKMGRIVTDRLEEFFPRLVDYDFTARMEEELDDIA 545
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490999310 555 NHQAEWRQVLDHFFGDFTTQLETAEKDPEEGGMQPNPMVLTSIDCPTCGRQMGIRTASTGVFLGCSGYALppKERCKTTI 634
Cdd:PRK07561 546 NGEADWKPVLDDFYKDFSQQLEKAEELREEGGMRPNQMVITDRDCPTCGRGMGIRTGKTGVFLGCSGYAL--KERCKTTR 623
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490999310 635 NLVPENEVLNVLEGDDAETNALRAKrrcQKCGTAM-------DSYLI----DPKRKLHVC-GNNPTCDGYEIEEGEFRIK 702
Cdd:PRK07561 624 NLTPEEETLNVLEGEDAETRALGAD---PECGTAMvlrsgrfGPYVQegegDKPRRLSLPkGNNPECVGLEIALGLLSLP 700
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490999310 703 gydGPVVECEKCGSEMHLKMGRFGKYMAC--TNDECKNTRKILRNGEVAP---------PKEDPVPLPELPCEKSDAFFV 771
Cdd:PRK07561 701 ---RPVGEHPECGSEIQAKIGRFGPYVKCggTYASLKNTRKVLTIGLNRAvellaepkrPKEDPVPLPELGCPKSGAPFV 777
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490999310 772 LRDGAAGVFL----AANTFPKSRETRAPLVEELYRFRDRLPEKLRYLADAPQQDPEGNKTLVRFSRKTKQQYVASEKDGK 847
Cdd:PRK07561 778 LRDGRYGPYVkhgkANATLPKGRETRAPTVEEALELLAEKPEKLRYLADAPAKDPAGKKAAVKFSRKTKQQYVASEKDGK 857
|
..
gi 490999310 848 AT 849
Cdd:PRK07561 858 AT 859
|
|
| topA_bact |
TIGR01051 |
DNA topoisomerase I, bacterial; This model describes DNA topoisomerase I among the members of ... |
5-637 |
0e+00 |
|
DNA topoisomerase I, bacterial; This model describes DNA topoisomerase I among the members of bacteria. DNA topoisomerase I transiently cleaves one DNA strand and thus relaxes negatively supercoiled DNA during replication, transcription and recombination events. [DNA metabolism, DNA replication, recombination, and repair]
Pssm-ID: 273416 [Multi-domain] Cd Length: 610 Bit Score: 911.38 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490999310 5 LVIVESPAKAKTINKYLGNDYVVKSSVGHIRDLPTSgsaskksadststkgakkpkkdersalvnRMGVDPWHDWDAQYE 84
Cdd:TIGR01051 1 LVIVESPAKAKTIKKYLGDEYEVEASMGHIRDLPKS-----------------------------RLGVDIEKDFEPEYV 51
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490999310 85 VLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIAWHLREVIGGDEKRYSRVVFNEITKNAIRQAFDKPGELNIDRVNA 164
Cdd:TIGR01051 52 VSKGKKKVVKELKTLAKKADEVYLATDPDREGEAIAWHLAEVLKPKDPVYKRIVFNEITKKAIRAALKNPREIDMNLVNA 131
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490999310 165 QQARRFMDRVVGYMVSPLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEIDASTTTpGGDALPLQVTHKHDK 244
Cdd:TIGR01051 132 QQARRILDRLVGYTLSPLLWKKVAKGLSAGRVQSVALRLIVDREREIKRFVPEEYWTIDATFQK-GEETFEALLTEVNGK 210
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490999310 245 PFRPV---NRDETMAAVALLEKASYSVLEREDKPTSSKPGAPFITSTLQQAASTRLGFGVKKTMMMAQRLYEA------- 314
Cdd:TIGR01051 211 KLKAGsdlDEAEATALKEQLKGEELVVEEIEKKPKKSRPPPPFTTSTLQQEASRKLGFSAKKTMMIAQRLYEGvstgdgt 290
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490999310 315 -GYITYMRTDSTNLSQDALSMVRGYIGDNFGKKYLPENANQYASKE-NSQEAHEAIRPSDVNVMAEDLK-GMEADALKLY 391
Cdd:TIGR01051 291 iGLITYMRTDSTRLSNQAVNEARNLIDKNYGKEYLGPKPKRYKSKEkNAQEAHEAIRPTSVFRTPEELKdYLKRDEFRLY 370
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490999310 392 QLIWRQFVACQMTPAQYDSTTLTVKA--GDFKLKARGRTLRFDGWTKVMPALRKG---DEDRTLPVVNQGESLSLVELTP 466
Cdd:TIGR01051 371 ELIWKRFVASQMADARYDSTSVRLTNedGEYVFKATGRKLIFDGYYKVYVEGSDDpleEKDRILPPLKEGDAVKLVEVKP 450
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490999310 467 AQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRRFYAEKMGEIVTDRLEENFRDLMNYDFTAQM 546
Cdd:TIGR01051 451 NQHFTQPPARYTEASLVKELEELGIGRPSTYASIISTIQDRGYVKKENKRLYPTELGFAVTDLLEKHFGDVVDYDFTAKM 530
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490999310 547 EDRLDQVANHQAEWRQVLDHFFGDFTTQLETAEKdpeeggMQPNPMVLTSIDCPTCGRQMGIRTASTGVFLGCSGYalpp 626
Cdd:TIGR01051 531 EKDLDEIAEGKAEWKPVLKNFYTGFSSKVKKLRN------MRIIVDFKTSQDCPLCGRPMVVKLGKYGPFLACSNF---- 600
|
650
....*....|.
gi 490999310 627 kERCKTTINLV 637
Cdd:TIGR01051 601 -PECKYTKSIV 610
|
|
| PRK06599 |
PRK06599 |
DNA topoisomerase I; Validated |
1-742 |
0e+00 |
|
DNA topoisomerase I; Validated
Pssm-ID: 235840 [Multi-domain] Cd Length: 675 Bit Score: 878.42 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490999310 1 MGKALVIVESPAKAKTINKYLGNDYVVKSSVGHIRDLPtsgsaskksadstSTKGakkpkkdersalvnrmGVDPWHDWD 80
Cdd:PRK06599 1 MAKKLVIVESPAKAKTIKKYLGKDYKVLASFGHVRDLP-------------KKKG----------------GVDPDNDFA 51
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490999310 81 AQYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIAWHLREVIG---GDEKRYSRVVFNEITKNAIRQAFDKPGEL 157
Cdd:PRK06599 52 PKYEIIEGKEKVVDALKKAAKKADAVYLATDPDREGEAIAWHIAEVLKeakLKDKNVKRVVFNEITKKAVQEAIENPRDI 131
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490999310 158 NIDRVNAQQARRFMDRVVGYMVSPLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEIDASTTTPGGDALPLQ 237
Cdd:PRK06599 132 DMDLVDAQQARRALDYLVGFKLSPLLWKKVRRGLSAGRVQSVALRLICEREDEIEAFIPQEYWTIEADLATSNGEPFTAK 211
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490999310 238 VTHKHDK---PFRPVNRDETMAAVALLEKASYSVLEREDKPTSSKPGAPFITSTLQQAASTRLGFGVKKTMMMAQRLYEA 314
Cdd:PRK06599 212 LVEVNGKkleKFSITNEEQAKALVKALEGQAYTVDKIEKKERKRNPPPPFITSTLQQEASRKLGFSAKKTMRIAQKLYEG 291
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490999310 315 --------GYITYMRTDSTNLSQDALSMVRGYIGDNFGKKYLPENANQYASK-ENSQEAHEAIRPSDVNVMAEDLKG-ME 384
Cdd:PRK06599 292 idlgegtvGLITYMRTDSVRLSNEALDEARKYITKKYGKEYLPAKPRVYKKKsKNAQEAHEAIRPTSINRTPESLKPyLT 371
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490999310 385 ADALKLYQLIWRQFVACQMTPAQYDSTTLTVKA--GDFKLKARGRTLRFDGWTKVMPA---LRKGDEDRTLPVVNQGESL 459
Cdd:PRK06599 372 PDQFKLYELIWKRTVASQMAPAILDQTSVDIASenGKYVFRATGSVILFPGFLKVYGEskdDEEEDDEKLLPPLKEGEKL 451
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490999310 460 SLVELTPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRRFYAEKMGEIVTDRLEENFRDLMN 539
Cdd:PRK06599 452 KLDELLPEQHFTEPPPRYSEASLVKKLEEYGIGRPSTYASIISTLQDREYVELEKKRFIPTDLGRIVNDFLVEHFPKYVD 531
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490999310 540 YDFTAQMEDRLDQVANHQAEWRQVLDHFFGDFTTQLETAEKDPEEggmQPNPMVLTSIDCPTC-GRQMGIRTASTGVFLG 618
Cdd:PRK06599 532 YDFTAGLEDELDEIAEGKKDWKPVLREFWEPFISNLEKVEEDVRT---EKVTQEETDETCPKCgGGPLVLKLGKNGKFLG 608
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490999310 619 CSGYalpPKerCKTTINLVPENEVlnvlegddaetnalrakrrcqkcgtamdsylidpkrklhvcgnnptcdgyEIEEGE 698
Cdd:PRK06599 609 CSGY---PE--CKYTKNITRDEDE--------------------------------------------------PIEEEE 633
|
730 740 750 760
....*....|....*....|....*....|....*....|....*
gi 490999310 699 FRikgydgPVVECEKCGSEMHLKMGRFGKYMACTND-ECKNTRKI 742
Cdd:PRK06599 634 IV------EEEKCPKCGGPLVLKKGRYGKFLACSGYpECKHIKPL 672
|
|
| TopA |
COG0550 |
DNA topoisomerase IA [Replication, recombination and repair]; |
3-576 |
0e+00 |
|
DNA topoisomerase IA [Replication, recombination and repair];
Pssm-ID: 440316 [Multi-domain] Cd Length: 541 Bit Score: 863.25 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490999310 3 KALVIVESPAKAKTINKYLGNDYVVKSSVGHIRDLPTSGsaskksadststkgakkpkkdersalvnrMGVDPWHDWDAQ 82
Cdd:COG0550 1 KKLVIVESPAKAKTIAKYLGKDYVVTASVGHLRDLPKPE-----------------------------LDVDVENDFEPK 51
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490999310 83 YEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIAWHLREVIGgDEKRYSRVVFNEITKNAIRQAFDKPGELNIDRV 162
Cdd:COG0550 52 YEVIPGKKKQVKELKKLAKKADEVILATDPDREGEAIAWHLLELLG-DKKPVKRVVFNEITKKAIKEAFKNPRDIDMNLV 130
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490999310 163 NAQQARRFMDRVVGYMVSPLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEIDASTTTPGGdalPLQVTHKH 242
Cdd:COG0550 131 DAQQARRILDRLVGYNLSPLLWKKVKRGLSAGRVQSPALRLIVEREREIEAFVPEEYWTIEATFKTGGG---EFTAKLVK 207
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490999310 243 DKPFRPVNRDETMAAVALLEKASYSVLEREDKPTSSKPGAPFITSTLQQAASTRLGFGVKKTMMMAQRLYEAGYITYMRT 322
Cdd:COG0550 208 IDGKKILDEEEAEAILAALKGKTFTVTSVEKKPKKRNPPPPFTTSTLQQEASRKLGFSAKKTMSIAQRLYEVGLITYMRT 287
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490999310 323 DSTNLSQDALSMVRGYIGDNFGKKYLPENANQYASKENSQEAHEAIRPSDVNVMAEDLkgmEADALKLYQLIWRQFVACQ 402
Cdd:COG0550 288 DSVRLSEDAVAAAREYIEALYGKEYLPEKPRVYKTSKNAQEAHEAIRPTGVTRTPESL---SGDEFKLYDLIWKRFLASQ 364
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490999310 403 MTPAQYDSTTLTVKAGDFKLKARGRTLRFDGWTKVMPALR---KGDEDRTLPVVNQGESLSLVELTPAQHFTKPPARFSE 479
Cdd:COG0550 365 MPPAEYETTTVTIEVGGEEFRASGKVIKFPGFLKVYGEGKddeEEEEEKRLPPLKEGEKLKLKKIEPEQHFTKPPPRYTE 444
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490999310 480 ASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRRFYAEKMGEIVTDRLEENFRDLMNYDFTAQMEDRLDQVANHQAE 559
Cdd:COG0550 445 ASLVKAMEELGIGRPSTYASIIETLQDRGYVEREGKRLVPTELGFIVIDLLEEHFPDLVDYEFTAKMEEKLDEIAEGKLD 524
|
570
....*....|....*..
gi 490999310 560 WRQVLDHFFGDFTTQLE 576
Cdd:COG0550 525 WKDVLEEFYKPFKELVE 541
|
|
| PRK06319 |
PRK06319 |
DNA topoisomerase I/SWI domain fusion protein; Validated |
1-787 |
0e+00 |
|
DNA topoisomerase I/SWI domain fusion protein; Validated
Pssm-ID: 235778 [Multi-domain] Cd Length: 860 Bit Score: 600.27 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490999310 1 MGKALVIVESPAKAKTINKYLGNDYVVKSSVGHIRDLPTSGsaskksadststkgakkpkkdersalvnrMGVDPWHDWD 80
Cdd:PRK06319 1 MKKSLIIVESPAKIKTLQKLLGEGFIFASSLGHIVDLPAKE-----------------------------FGIDIENDFE 51
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490999310 81 AQYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIAWHLREVIGgDEKRYSRVVFNEITKNAIRQAFDKPGELNID 160
Cdd:PRK06319 52 PDYQILPDKEEVINKICKLAKKCDVVYLSPDPDREGEAIAWHIANQLP-KNTKIQRISFNAITKGAVTEALKHPREIDMA 130
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490999310 161 RVNAQQARRFMDRVVGYMVSPLLWKKIAR--GLSAGRVQSVAVRLVVEREREIKAFVPEEFWEIDASTTTPGGDALPLQV 238
Cdd:PRK06319 131 LVNAQQARRLLDRIVGYKISPILSRKLQRrsGVSAGRVQSVALKLVVDREKAIEAFVPVEYWNIRVHLKDPKTQKTFWAH 210
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490999310 239 TH--------------KHDKPFRPVNRDETM-AAVALLEKASYSVLEREDKPTSSKPGAPFITSTLQQAASTRLGFGVKK 303
Cdd:PRK06319 211 LYsvdgkkwekeipegKTEDEVLLINSKEKAdHIVELLESATYTVTRVESKEKRRNAYPPFITSTLQQEASRHFRFSSSR 290
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490999310 304 TMMMAQRLYEA---------GYITYMRTDSTNLSQDALSMVRGYIGDNFGKKYLPENANQYASKENSQEAHEAIRPSDVN 374
Cdd:PRK06319 291 TMNIAQTLYEGvdldsegatGLITYMRTDSVRTDPEALKQVRKYIEGTFGKEFLPSSPNVYTTKKMAQDAHEAIRPTDIT 370
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490999310 375 VMAEDLKG-MEADALKLYQLIWRQFVACQMTPAQYDSTTLTVKAG-DFKLKARGRTLRFDGWTKVMPALR----KGDEDR 448
Cdd:PRK06319 371 LTPEKLRSkLTEDQYKLYSLIWKRFVASQMIPAIYDTLAIRITTNkGIDLRATGSLLKFKGFLAVYEEKRddegDEEENI 450
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490999310 449 TLPVVNQGESLSLVELTPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRRFYAEKMGEIVTD 528
Cdd:PRK06319 451 HLPKLHEQDVLTKEELSAEQAFTKPLPRFTEASLVKELEKSGIGRPSTYATIMNKIQSREYTLKENQRLRPTELGKIISQ 530
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490999310 529 RLEENFRDLMNYDFTAQMEDRLDQVANHQAEWRQVLDHFFGDFTTQLETAEKDPEEggmqpnPMVLTSIDCPTCGRQMGI 608
Cdd:PRK06319 531 FLETNFPRIMDIGFTALMEDELELIADNKKPWKLLLQEFWELFLPVVVTAEKEAFI------PRIVTEIDCPKCHKGKLV 604
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490999310 609 RT-ASTGVFLGCSGYalppkerckttinlvpenevlnvlegddaetnalrakrrcqkcgtamdsylidpkrklhvcgnnP 687
Cdd:PRK06319 605 KIwAKNRYFYGCSEY----------------------------------------------------------------P 620
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490999310 688 TCDgYEIEEGE--FRIKGY------DGPvveCEKCGSEMHLKMGRFGKYMACTN-DECKNTRKILRNGEVAPPKEDPVPL 758
Cdd:PRK06319 621 ECD-YKTSEEEltFNKEDYaedtpwDSP---CPLCGGEMKVRHGRFGTFLGCENyPECRGIINIHKKGEEGIEPEETVPC 696
|
810 820
....*....|....*....|....*....
gi 490999310 759 PELPCekSDAFFVLRDGAAGVFLAANTFP 787
Cdd:PRK06319 697 PAIGC--TGHIVKRRSRFNKMFYSCSEYP 723
|
|
| PRK08780 |
PRK08780 |
DNA topoisomerase I; Provisional |
1-579 |
0e+00 |
|
DNA topoisomerase I; Provisional
Pssm-ID: 181555 [Multi-domain] Cd Length: 780 Bit Score: 564.00 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490999310 1 MGKALVIVESPAKAKTINKYLGNDYVVKSSVGHIRDL-PTSGSaskksadststkgakkpkkdersalvnrmgVDPWHDW 79
Cdd:PRK08780 1 MSKHLVIVESPAKAKTINKYLGKDFTVLASYGHVRDLvPKEGA------------------------------VDPENGF 50
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490999310 80 DAQYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIAWHLREVIGG----DEKRYSRVVFNEITKNAIRQAFDKPG 155
Cdd:PRK08780 51 AMRYDLIDKNEKHVEAIAKAAKSADDLYLATDPDREGEAISWHLAEILKErgllKDKPMQRVVFTEITPRAIKEAMAKPR 130
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490999310 156 ELNIDRVNAQQARRFMDRVVGYMVSPLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEIDASTTTPGgDALP 235
Cdd:PRK08780 131 DIASDLVDAQQARRALDYLVGFNLSPLLWRKIQRGLSAGRVQSPALRMIVEREEEIEAFIAREYWSIEADCAHPS-QPFN 209
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490999310 236 LQVTHKHDKPFRP---VNRDETMAAVALLEKASYSVL---EREDKPTSSKPGAPFITSTLQQAASTRLGFGVKKTMMMAQ 309
Cdd:PRK08780 210 AKLIKLDGQKFEQftiTDGDTAEAARLRIQQAAQGTLhvtDVESKERKRNPAPPFTTSTLQQEASRKLGFTTRRTMQVAQ 289
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490999310 310 RLYEA---------GYITYMRTDSTNLSQDALSMVRGYIGDNFGKKYLPENANQYASK-ENSQEAHEAIRPSDVNVMAED 379
Cdd:PRK08780 290 KLYEGvdlgdegsvGLITYMRTDSVNLSQDALAEIRDVIARDYGTASLPDQPNTYKTKsKNAQEAHEAVRPTSALRTPAQ 369
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490999310 380 LKG-MEADALKLYQLIWRQFVACQMTPAQYDSTTLTVKAGD-FKLKARGRTLRFDGWTKVMPALR------KGDEDRTLP 451
Cdd:PRK08780 370 VARfLSDDQRRLYELIWKRAVACQMIPATLNTVSVDLAAGSeHVFRATGSTVVVPGFLAVYEEGKddksaeDEDEGRKLP 449
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490999310 452 VVNQGESLSLVELTPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRRFYAEKMGEIVTDRLE 531
Cdd:PRK08780 450 PMKEGDNVPLERIRAEQHFTEPPPRYTEASLVKALEEYGIGRPSTYASIISTLQFRKYVEMEGRRFRPTDVGRAVNKFLT 529
|
570 580 590 600
....*....|....*....|....*....|....*....|....*...
gi 490999310 532 ENFRDLMNYDFTAQMEDRLDQVANHQAEWRQVLDHFFGDFTTQLETAE 579
Cdd:PRK08780 530 GHFTRYVDYDFTARLEDDLDAVSRGEKEWIPLMEKFWGPFKELVEEKK 577
|
|
| TOP1Ac |
cd00186 |
DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA ... |
159-571 |
2.89e-169 |
|
DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA and then rejoin the broken phosphodiester backbone. Proposed catalytic mechanism of single stranded DNA cleavage is by phosphoryl transfer through a tyrosine nucleophile using acid/base catalysis. Tyr is activated by a nearby group (not yet identified) acting as a general base for nucleophilic attack on the 5' phosphate of the scissile bond. Arg and Lys stabilize the pentavalent transition state. Glu then acts as a proton donor for the leaving 3'-oxygen, upon cleavage of the scissile strand.
Pssm-ID: 238110 [Multi-domain] Cd Length: 381 Bit Score: 495.59 E-value: 2.89e-169
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490999310 159 IDRVNAQQARRFMDRVVGYMVSPLLWKKIAR--GLSAGRVQSVAVRLVVEREREIKAFVPEEFWEIDASTttpggdalpl 236
Cdd:cd00186 1 ENLVNAQLARRILDRLVGFNLSRLLTKKLRRkgVLSAGRVQSPTLGLIVEREREIKAFVPEDYWEIKEAV---------- 70
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490999310 237 qvthkhdkpfrpvnrdetmaavallekasysVLEREDKPTSSKPGAPFITSTLQQAASTRLGFGVKKTMMMAQRLYEAGY 316
Cdd:cd00186 71 -------------------------------VVSVEKKEKKKNPPPPFTTSTLQQEASSKLGFSAKKTMQIAQKLYEAGL 119
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490999310 317 ITYMRTDSTNLSQDALSMVRGYIGDNFGKKYLPENANQ----YASKENSQEAHEAIRPSDVNVMAEDLKGMEADALKLYQ 392
Cdd:cd00186 120 ITYPRTDSTRLSEEAILEAREYIQAIYGKEYLYPAPLLgrrnPKRGKKEQGAHEAIRPTKVAPTPELEANLSEDEFKLYE 199
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490999310 393 LIWRQFVACQMTPAQYDSTTLTVKAGDFKLKARGRTLRFDGWTKVMPALRKGDEDrTLPVVNQGESLSLVELTPAQHFTK 472
Cdd:cd00186 200 LIWRRFLASQMADAKYEETTVTLEIGGEKFKASGKVLLEDGWLEVYPEEKDDEEE-EPPPLKEGDELKLEEVELEEKETQ 278
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490999310 473 PPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRRFYAEKMGEIVTDRLEENFRDLMNYDFTAQMEDRLDQ 552
Cdd:cd00186 279 PPPRYTEASLIKLMEKRGIGRPSTYASIIETLLDRGYVEKEKKKLIPTELGFAVIELLEKHFPELVDPEFTAKLEEKLDE 358
|
410
....*....|....*....
gi 490999310 553 VANHQAEWRQVLDHFFGDF 571
Cdd:cd00186 359 IAEGKKDYQEVLEEFYEEF 377
|
|
| Topoisom_bac |
pfam01131 |
DNA topoisomerase; This subfamily of topoisomerase is divided on the basis that these enzymes ... |
156-565 |
5.27e-159 |
|
DNA topoisomerase; This subfamily of topoisomerase is divided on the basis that these enzymes preferentially relax negatively supercoiled DNA, from a 5' phospho- tyrosine linkage in the enzyme-DNA covalent intermediate and has high affinity for single stranded DNA.
Pssm-ID: 426069 [Multi-domain] Cd Length: 410 Bit Score: 470.19 E-value: 5.27e-159
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490999310 156 ELNIDRVNAQQARRFMDRVVGYMVSPLLWKKI--ARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEIDASTTTPGGDA 233
Cdd:pfam01131 1 EIDENLVDAQLARRELDWLIGFNLSRLLTLKLkgNKLLSAGRVQTPTLALIVEREREIENFVPEPYWTIEATLKDGGGVF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490999310 234 lplqvTHKHDKPFRPVNRDETMAAVALLEKASYSVLEREDKPTSSKPGAPFITSTLQQAASTRLGFGVKKTMMMAQRLYE 313
Cdd:pfam01131 81 -----ANAKWKRGRIFDKEEAEAILEKLKKGTAVVTSVESKEKKKPPPLPFNTTTLQKEASRKLGFSAKKTMSIAQKLYE 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490999310 314 -AGYITYMRTDSTNLSQDA-LSMVRGYIGDNFGK--KYLPENANQYASK---ENSQ-EAHEAIRPSDVNVMAEDLKGmea 385
Cdd:pfam01131 156 kHGLITYPRTDSTYLSDDAtLKAILEYLTKNYGKylPYAPRLLKKTKGKltvGNAKvTAHEAIRPTGDIPVLPELSD--- 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490999310 386 DALKLYQLIWRQFVACQMTPAQYDSTTLTVKAGDFKLKARGRTLRFDGWTKVMPALRKgDEDRTLPVVNQGESLSLVELT 465
Cdd:pfam01131 233 DERKLYELIVRRFLASQMPPAVYETTTVVLEVGGEEFRASGKVILEDGWLKVYPYEKK-EDEEELPELKEGEELKVTQVE 311
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490999310 466 PAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRRFYAEKMGEIVTDRLeENFRDLMNYDFTAQ 545
Cdd:pfam01131 312 VEEKKTKPPPRYTEASLIKAMEKAGIGTPATRATIIETLLERGYVERKKKSLVPTELGKALVEAL-EKFPDLVDPELTAE 390
|
410 420
....*....|....*....|
gi 490999310 546 MEDRLDQVANHQAEWRQVLD 565
Cdd:pfam01131 391 LEEKLDEIAEGKLDWKDVLA 410
|
|
| TOP1Ac |
smart00437 |
Bacterial DNA topoisomerase I DNA-binding domain; Bacterial DNA topoisomerase I and III, ... |
272-526 |
6.23e-118 |
|
Bacterial DNA topoisomerase I DNA-binding domain; Bacterial DNA topoisomerase I and III, Eukaryotic DNA topoisomeraes III, reverse gyrase alpha subunit
Pssm-ID: 214663 [Multi-domain] Cd Length: 259 Bit Score: 358.48 E-value: 6.23e-118
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490999310 272 EDKPTSSKPGAPFITSTLQQAASTRLGFGVKKTMMMAQRLYEAGYITYMRTDSTNLSQDALSMVRGYIGDNFGKKYLPEN 351
Cdd:smart00437 1 EEKEKKKNPPPPFTTSTLQQEASRKLGFSAKKTMQIAQKLYEKGLITYPRTDSTRLSEEAVLEARNYIQKLYGKEYLDLA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490999310 352 A-----NQYASKENSQEAHEAIRPSDVNVMAEDLKGMEADALKLYQLIWRQFVACQMTPAQYDSTTLTVKAGDFKLKARG 426
Cdd:smart00437 81 VvllkpRKPRKGKKAQGAHEAIRPTKPIFTPELEKELSEDEFKLYELIWRRFLASQMPDAKYEETKVTIKIGGEKFKAKG 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490999310 427 RTLRFDGWTKVMPALRKgDEDRTLPVVNQGESLSLVELTPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQD 506
Cdd:smart00437 161 KTLLFDGWLKVYPEEKK-EEEIELPTLKKGDELKVEEVEVEEKETKPPARYTEASLIKLMEKRGIGRPSTYASIIETLLD 239
|
250 260
....*....|....*....|
gi 490999310 507 RGYVRVENRRFYAEKMGEIV 526
Cdd:smart00437 240 RGYVTKKKKKLIPTELGIAV 259
|
|
| PRK07219 |
PRK07219 |
DNA topoisomerase I; Validated |
5-793 |
1.08e-98 |
|
DNA topoisomerase I; Validated
Pssm-ID: 235971 [Multi-domain] Cd Length: 822 Bit Score: 326.57 E-value: 1.08e-98
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490999310 5 LVIVESPAKAKTINKYLGNdyvvkssvghirdlptsGSASKKSADSTSTK--GAKKPKKDERSALVNRMGVD---PWHDW 79
Cdd:PRK07219 3 LIIAEKNNAARRIADILSG-----------------GKAKKKRVNGVPYYefERKGEKWIVIGLSGHIVTVDfpeEYGDW 65
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490999310 80 ---------DAQYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAI---AWHLREVIGGDEKRysRVVFNEITKNAI 147
Cdd:PRK07219 66 rdvdpaeliDADPVKKITKQNYINALKKLAKDADEIIIATDYDREGELIgkeAYHILREVCQVPVK--RARFSSLTKKEI 143
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490999310 148 RQAFDKPGELNIDRVNAQQARRFMDRVVGYMVSPLLW---KKIARG--LSAGRVQSVAVRLVVEREREIKAFVPEEFWEI 222
Cdd:PRK07219 144 RKAFENPDEIDFNLADAGEARQIIDLYWGAALTRFLSlsvRQLGRWdfLSVGRVQTPTLAFIVDREREIRAFDPEDYWKI 223
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490999310 223 DAS-TTTPGGDALPLQVTHKHDKPFrpvnrDETMAAVA---LLEKASYSVLEREDKPTSSKPGAPFITSTLQQAASTRLG 298
Cdd:PRK07219 224 EALlDKEAQYFYRDLIGGHEAEKFW-----DEEEAEEIyekLKGAKEATVSSVKKRERTISPPAPFNTTEFLREASKIFG 298
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490999310 299 FGVKKTMMMAQRLYEAGYITYMRTDSTNLSQDaLSM-------VRGYIGDNFGKKYLPENANQYASKENSQEAHEAIRPS 371
Cdd:PRK07219 299 ISPKRAMEIAEKLYTAGYISYPRTDNTVYPDD-LDPkellkklSKKKEYGPYAESILEQENIKPTEGKKETTDHPPIHPV 377
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490999310 372 DVnVMAEDLKGmeaDALKLYQLIWRQFVACQMTPAQYDSTTLTVKAGDFKLKARGRTLRFDGWTKVMPALRKgdEDRTLP 451
Cdd:PRK07219 378 DV-PKREELSD---DEWKVYELIVRRFLATLADPAEWEYLKVELDVNGEIFKASGSRLVEEGWHEVYPYEKF--DEKELP 451
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490999310 452 VVNQGESLSLVELTPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVrVENRRFYAEKMGEIVTDRLE 531
Cdd:PRK07219 452 DLEEGEKLKVNKIEIEAKETQPPKRYTQSSLIKEMEKRGLGTKATRHDIIEKLYKRGYV-IEGDPPRPTDLGIAVIEALE 530
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490999310 532 ENFRDLMNYDFTAQMEDRLDQVANHQA-------EWRQVLDHFFGDFTTQlETAEKDPEEGGMQPNPMVLTSI-DCPTCG 603
Cdd:PRK07219 531 KYAPEIVSEEMTAQLEADMQAIEDGKKkkedvteESREMLKEILSELKEK-RKEIGDHLAGSLKAENRSLKTIgKCPECG 609
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490999310 604 RQMGIRTASTGV-FLGCSGYalppkERCKTTINLvPENEVLNVLEgddaetnalrakRRCQKCGTAMDSYLIDPKRKLHV 682
Cdd:PRK07219 610 GDLIIIRTDKGSrFVGCSGY-----PDCRNTFPL-PSTGRIKVLD------------EVCEKCGLPVIKILRGKQTFVVG 671
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490999310 683 CgnnPTCDGYEIEEGEFRIKGydgpvvECEKCGSEMHLKMGRFGKYMACTN-DECKNTRKILRNGEVAPPKEDpvplpel 761
Cdd:PRK07219 672 C---PDCEAEKEEEDPDEVIG------PCPKCGGELAIKQLKYGSFLGCTNyPKCKYTLPLPRRGKITVTDEK------- 735
|
810 820 830
....*....|....*....|....*....|..
gi 490999310 762 pCEKSDAFFVLRDGAAGVFLAANTFPKSRETR 793
Cdd:PRK07219 736 -CPECGLPLLRVKGGFGDELGCCNNPKCNYTE 766
|
|
| TopG2 |
COG1110 |
Reverse gyrase [Replication, recombination and repair]; |
4-568 |
7.77e-88 |
|
Reverse gyrase [Replication, recombination and repair];
Pssm-ID: 440727 [Multi-domain] Cd Length: 1219 Bit Score: 303.82 E-value: 7.77e-88
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490999310 4 ALVIVESPAKAKTINKYLGN-----------------DYV--VKSSVGHIRDLPTSGSAS-------------------K 45
Cdd:COG1110 631 ALVIVESPNKARTIASFFGKpsrrrigglrvyevsigDYLllITASGGHVFDLVTEAYARgfygvlvengrfipvydtiK 710
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490999310 46 KSAD--STSTKGAKKPKKDERSALVNrmgvdpwhdwdaqyevlpgKEKVVSELKQLAEKADHIYLATDLDREGEAIAWHL 123
Cdd:COG1110 711 RCLDcgEQFTDEVEVCPRCGSPNIVD-------------------SLEIVEALRELATEVDEVLIGTDPDTEGEKIGWDV 771
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490999310 124 REVIGGDEKRYSRVVFNEITKNAIRQAFDKPGELNIDRVNAQQARRFMDRVVGYMVSPLLWKKIARG-LSAGRVQSVAVR 202
Cdd:COG1110 772 YNLLRPYAKNIKRIEFHEVTRKAILEALKNPREIDENLVEAQIVRRIEDRWIGFTLSQKLWKVFGNRnLSAGRVQTPVLG 851
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490999310 203 LVVEREREikaFVPEEFWEIdaSTTTPGGdalPLQVTHKHDKPFRPVNRdetmaAVALLEKASYSVLEREDKPTSSKPga 282
Cdd:COG1110 852 WIIERYEE---SRKSKKYLI--ILTLENG---RLELSIEDLKEAEEVRK-----ALEKEVKVKVKKVEEEEEELNPLP-- 916
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490999310 283 PFITSTLQQAASTRLGFGVKKTMMMAQRLYEAGYITYMRTDSTNLSQDALSMVRGYIGDNFGKKYLpenanqYASKENSQ 362
Cdd:COG1110 917 PYTTDTLLRDASRRLGLSAEETMRLAQDLFESGLITYHRTDSTRVSDAGIAVAKEYISERFGEEYF------KPRRWGEG 990
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490999310 363 EAHEAIRPS---DvnvmAEDLKGM------------EADALKLYQLIWRQFVACQMTPA--QYDSTTLTVKAGDFKLKAR 425
Cdd:COG1110 991 GAHEAIRPTrplD----AEDLRRLieegvielpiplTRRHLRLYDLIFRRFMASQMRPAkvEKVKLRVSLELPGGEIEEE 1066
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490999310 426 GRT-LRFDGWTKVMPALRKGDEdrtlpvVNQGEslslVELTPAQHFTKPPAR-FSEASLVKELEKRGIGRPSTYASIIST 503
Cdd:COG1110 1067 RIVeIIEDGFLLIYPPIKVEPE------LKEGE----YKVTEVKIRKVPKVPlYTQGDLVREMKERGIGRPSTYAKIVET 1136
|
570 580 590 600 610 620
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 490999310 504 IQDRGYVRVENRR--FYAEKMGEIVTDRLEENFRDLMNYDFTAQMEDRLDQVANHQAEWRQVLDHFF 568
Cdd:COG1110 1137 LLRRGYVVESKKGkkLVPTKLGIEVYNYLSENFPDLVSEERTRELEEKMDEIEEGEADYQDVLEELY 1203
|
|
| rgy |
TIGR01054 |
reverse gyrase; This model describes reverse gyrase, found in both archaeal and bacterial ... |
4-568 |
2.17e-84 |
|
reverse gyrase; This model describes reverse gyrase, found in both archaeal and bacterial thermophiles. This enzyme, a fusion of a type I topoisomerase domain and a helicase domain, introduces positive supercoiling to increase the melting temperature of DNA double strands. Generally, these gyrases are encoded as a single polypeptide. An exception was found in Methanopyrus kandleri, where enzyme is split within the topoisomerase domain, yielding a heterodimer of gene products designated RgyB and RgyA. [DNA metabolism, DNA replication, recombination, and repair]
Pssm-ID: 273418 [Multi-domain] Cd Length: 1171 Bit Score: 293.66 E-value: 2.17e-84
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490999310 4 ALVIVESPAKAKTINKYLG-----------------NDYV--VKSSVGHIRDLPTSGS---------------ASKKSAD 49
Cdd:TIGR01054 603 ALLVVESPNKARTIARFFGkpsvrkiggsvvyevpvGDLIlmITASGGHVFDLVTDKGfhgvlvengryvpvyTSIKRCR 682
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490999310 50 STSTKGAKKPKKDERSALVNRMGvdpwhdwdaqyevlpgKEKVVSELKQLAEKADHIYLATDLDREGEAIAWHLREVIGG 129
Cdd:TIGR01054 683 DCGYQFTEDRESCPKCGSENIED----------------SKSIIEILRELAHEVDEVFIGTDPDTEGEKIGWDLALLLSP 746
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490999310 130 DEKRYSRVVFNEITKNAIRQAFDKPGELNIDRVNAQQARRFMDRVVGYMVSPLLWKKIA-RGLSAGRVQSVAVRLVVERE 208
Cdd:TIGR01054 747 YNPNVKRAEFHEVTRRAILEALESPRSVDENLVKAQVVRRIEDRWIGFTLSQKLWEAFNkRWLSAGRVQTPVLGWIIDRY 826
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490999310 209 REIKAFVPEEFWEIDAStttpggdALPLQVTHKHDKPFRPVNRDETMAAVALLEkasysvlEREDKPTsskPGAPFITST 288
Cdd:TIGR01054 827 RESREKRGYLLIFALES-------DFRLGLEHDNRLEAKEFEKDLTWLDVEDIA-------EREEERN---PLPPYTTDT 889
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490999310 289 LQQAASTRLGFGVKKTMMMAQRLYEAGYITYMRTDSTNLSQDALSMVRGYIGDNFGKKYlpenanQYASKENSQEAHEAI 368
Cdd:TIGR01054 890 MLEDANRKLGLSVKETMQIAQELFENGLITYHRTDSTRVSDVGMRVAKEYLASRLGGEY------FYPREWGEGGAHECI 963
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490999310 369 RPS------DVNVMAED----LKGMEADALKLYQLIWRQFVACQMTPAQYDSTTLTVKAGDFKLKARGRTLR-FDGWTKV 437
Cdd:TIGR01054 964 RPTrpldvdDLQRLILEgvieLEGLTREHLRLYDLIFRRFMASQMRPAKVDTKEITLKADGKEAEEEGIVEIvERGFELV 1043
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490999310 438 MPALRKGD-EDRTLPVVNQGESLSLVELTPaqhftkpparFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRR 516
Cdd:TIGR01054 1044 YPLWRKNElEKGSTFIVKDKELRSVPKVYP----------YTQGEIVQEMKERGIGRPSTYATIVEKLLRRGYVVESKGF 1113
|
570 580 590 600 610
....*....|....*....|....*....|....*....|....*....|..
gi 490999310 517 FYAEKMGEIVTDRLEENFRDLMNYDFTAQMEDRLDQVANHQAEWRQVLDHFF 568
Cdd:TIGR01054 1114 LIPTKLGIEVYNYLTNRYPKLVSEDRTRELEEAMDKIERGELDYLEVLESVY 1165
|
|
| PRK07726 |
PRK07726 |
DNA topoisomerase 3; |
82-622 |
1.52e-81 |
|
DNA topoisomerase 3;
Pssm-ID: 236078 [Multi-domain] Cd Length: 658 Bit Score: 275.89 E-value: 1.52e-81
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490999310 82 QYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIAwhlREVIG--GDEKRYSRVVFNEITKNAIRQAFD--KPGEL 157
Cdd:PRK07726 72 KLVVKKKTAKQFNVVKKLLKQATEIVIATDADREGELIA---REILDycGVRKPIKRLWISSLTDKAIKRAFAnlKPGKE 148
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490999310 158 NIDRVNAQQARRFMDRVVGYMVSPLLWKKIARG-----LSAGRVQSVAVRLVVEREREIKAFVPEEFWEIDASTTtpGGD 232
Cdd:PRK07726 149 TIPLYYSALARSRADWLVGINMTRAYTLLGRKAgyngvLSVGRVQTPTLALVVRRDEEIENFVPKPYWEVEAHLT--PGE 226
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490999310 233 ALPLQVTHKH---DKPFRPVNRDETMAAVALLEKASYSVLEREDKPTSSKPGAPFITSTLQQAASTRLGFGVKKTMMMAQ 309
Cdd:PRK07726 227 RFTAKWQPSEpyqDEEGRLLDRPLAEQVVARIQGQPAKVTEVETKRKKEYAPLLYDLSELQIDANKRFGLSAKETLDIAQ 306
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490999310 310 RLYE-AGYITYMRTDSTNLSQD----------ALSMVRGYigdnfgKKYLPENANqyaSKENSQ-------EAHEAIRPS 371
Cdd:PRK07726 307 SLYEtHKLITYPRTDSRYLPEDmvatlpevlnAISKVDPY------LLLAPPVLD---PSIRSRawndkkvTAHHAIIPT 377
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490999310 372 DVNVmaeDLKGMEADALKLYQLIWRQFVACQMTPAQYDSTTLTVKAGDFKLKARGRTLRFDGWTKVMPALRKGDE-DRTL 450
Cdd:PRK07726 378 EQPP---NLSKLSEDERKVYDLIARRYLAQFLPPAEYDKTTIELEIAGGTFIAKGKQVVEAGWKALLGKKEEDEEkEQPL 454
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490999310 451 PVVNQGESLSLVELTPAQHFTKPPARFSEASLV------------KELEKR-----GIGRPSTYASIISTIQDRGYVRVE 513
Cdd:PRK07726 455 PVLAKGDELKVEKGEVKEGQTQPPKRFTEGTLLsameniarfvqdKELKKTlketdGLGTEATRAGIIEKLFKRGYLEKK 534
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490999310 514 NRRFYAEKMGEIVTDRLEEnfrDLMNYDFTAQMEDRLDQVANHQAEwrqvLDHFFGDfttQLETAEKDPEEGGMQPNPMV 593
Cdd:PRK07726 535 GKYIHATDKGKQLIDALPE---ELTSPDMTAKWEQALDQISEGQLS----YQDFMQP---LKQWLKQLVEQAKQSSEKYK 604
|
570 580 590
....*....|....*....|....*....|..
gi 490999310 594 LTSID---CPTCGRQMGIRTASTGVFLGCSGY 622
Cdd:PRK07726 605 FDNLTgpkCPDCGKPMLKVKGKNGKMLVCQDR 636
|
|
| topA_arch |
TIGR01057 |
DNA topoisomerase I, archaeal; This model describes topoisomerase I from archaea. These ... |
7-622 |
8.78e-75 |
|
DNA topoisomerase I, archaeal; This model describes topoisomerase I from archaea. These enzymes are involved in the control of DNA topology. DNA topoisomerase I belongs to the type I topoisomerases, which are ATP-independent. [DNA metabolism, DNA replication, recombination, and repair]
Pssm-ID: 273420 [Multi-domain] Cd Length: 618 Bit Score: 256.29 E-value: 8.78e-75
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490999310 7 IVESPAKAKTINKYLGNDYVVKSSVG------HIRDlptsgsaSKKSADSTSTKGAKKPKKDERsalvnrmGVDPWHD-- 78
Cdd:TIGR01057 1 IAEKPKVAAKIAGALSDGRVLKKSEYgvpyweVRRD-------GKKIIVASAVGHLFGLHPKSR-------GGYPVFDie 66
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490999310 79 WDAQYEVLPGKE---KVVSELKQLAEKADHIYLATDLDREGEAIAWHLREViGGDEKRYSRVVFNEITKNAIRQAFDKPG 155
Cdd:TIGR01057 67 WVPIFEFDKGKGyvsKYIKALSKLAKGADEYINACDYDIEGEVIGFKALKY-FCGVERAKRMKFSTLTKQDIRRAYANPE 145
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490999310 156 ELNIDRVNAQQARRFMDRVVGYMVSPLLWKKIARG------LSAGRVQSVAVRLVVEREREIKAFVPEEFWEIDASTTTP 229
Cdd:TIGR01057 146 EIDYGMVDAGMARHILDWYWGINLSRALMEAIRAAagrwviLSAGRVQGPTLAFLVEREREINLFVPKPYWVIKATLEKG 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490999310 230 GGdalPLQVTHKHDKPFrpvNRDETMAAVALLEKA-SYSVLEREDKPTSSKPGAPFITSTLQQAASTRLGFGVKKTMMMA 308
Cdd:TIGR01057 226 GG---VFDARPEKWKIW---SEEEAKSIKEELKKSpWAAVEEVRSERSILKPPPPFDLGTLQREAYRIFGFSPKKTQSIA 299
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490999310 309 QRLYEAGYITYMRTDSTNLSQDalsmvRGY--IGDNFGK-----------KYLPENANQYASKENsqEAHEAIRPSDvNV 375
Cdd:TIGR01057 300 QELYEEALISYPRTSSQKLPPS-----INYraILDNLAKgplyreaaerlLETGVLKPVEGKKED--PAHPAIHPTG-EI 371
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490999310 376 MAEDLKgmeADALKLYQLIWRQFVACQMTPAQYDSTTLTVKAGDFKLKARGRTLRFDGWTKVMPALRKGDEdrTLPVVNQ 455
Cdd:TIGR01057 372 PSQELS---KDEKKVYDLIVRRFLAAFSEEAIREKSKVLLRIGQEKFRLSGLRVVKLGWLEYYHYSKFEEK--ELPPLDR 446
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490999310 456 GESLSLVELTPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVrVENRRFYAEKMGEIVTDRLEENFR 535
Cdd:TIGR01057 447 GDKIKVVRVDVRVKETQPPARYDKASLIREMESRGLGTKATRARIIETLYKRGYI-EGKKSIKVTPLGEAVIETLQRYCP 525
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490999310 536 DLMNYDFTAQMEDRLDQVANHQAEWRQVLDHFFGDFTTQLETAEKDPEEGGMQPNPMVLTS---IDCPTCGRQMGIRTAS 612
Cdd:TIGR01057 526 EIISEELTRRFESKLEDIMSGRITKDEVIDEAKKRLRKILEEFKKRLDDIGIELGKSLGSVevvGKCPKCGGKLVSKYAK 605
|
650
....*....|
gi 490999310 613 TGVFLGCSGY 622
Cdd:TIGR01057 606 KGRFVGCSNY 615
|
|
| PRK07220 |
PRK07220 |
DNA topoisomerase I; Validated |
73-666 |
2.55e-69 |
|
DNA topoisomerase I; Validated
Pssm-ID: 180892 [Multi-domain] Cd Length: 740 Bit Score: 244.28 E-value: 2.55e-69
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490999310 73 VDPWHDWDAQYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAI---AWHLREVIGGDEKrYSRVVFNEITKNAIRQ 149
Cdd:PRK07220 68 VDARDLIDAEIITTPTQKKIVTALKKLGKEADRVTIATDYDREGELIgveALNIIKKVNPDIK-FDRVRYSAITKKEIER 146
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490999310 150 AFDKPGELNIDRVNAQQARRFMDRVVGYMVSPllWKKIARG------LSAGRVQSVAVRLVVEREREIKAFVPEEFWEID 223
Cdd:PRK07220 147 AFSNPVEVDFNLADAGHSRQVIDLVWGAALTR--YISLAAGrlgkmfLSVGRVQSPTLALIVDREKEREAFVPTPYWEIY 224
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490999310 224 ASTTTPGGdalPLQVTHKHDkpfRPVNRDETMAAVALLEKASySVLEREDKPTSSKPGAPFITSTLQQAASTrLGFGVKK 303
Cdd:PRK07220 225 ATLENNGE---TFVAQHSTR---RFWEKEEADRVFEKLGKTA-EVTEVEKGTKTDKPPTPFNTTEFISAANS-IGFSAAN 296
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490999310 304 TMMMAQRLYEAGYITYMRTDSTNL--SQDALSMVRGYIGDNFGK--KYLPENANQYASKENSQEA-HEAIRPSDVNVMAE 378
Cdd:PRK07220 297 AMRIAESLYTNGYISYPRTDNTVYpeSLDLREQIEIFAEGPFGEyaQKLLEKGELVPTRGKKETTdHPPIYPASLAKKSE 376
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490999310 379 dlkgMEADALKLYQLIWRQFVACQMTPAQYDSTTLTVKAGDFKLKARGRTLRFDGWTKVMPALRKgdEDRTLPVVNQGES 458
Cdd:PRK07220 377 ----LKEDEWKVYELVVRRFFATFAGPAEWETMKLRFDIGGEEFRANGSRLTEPGWRWYYPYNAP--EDRLLPELSEGEE 450
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490999310 459 LSLVELTPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVR----VENRRFYAekmgeiVTDRLEENF 534
Cdd:PRK07220 451 LKVKKKEMLDKETQPPGRYGQGRLIKLMEDLGLGTKATRHEIISKLYSRAYIHgnpiQPTNTAFA------VVDALEKYA 524
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490999310 535 RDLMNYDFTAQMEDRLDQVANHQA-------EWRQVLDHFFGDfttqLETAEKDPEE---GGMQPNPMVLTsidCPTCGR 604
Cdd:PRK07220 525 PTITKPDMTSRLEEDMDKIAEGKIkedavleESREMLEQVFDE----LDKNREKIREslrEGLREDKIIGK---CPLCGS 597
|
570 580 590 600 610 620
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 490999310 605 QMGIRTASTGV-FLGCSGYAlppkeRCKTTINLVPENEVLnVLEgddaetnalrakRRCQKCG 666
Cdd:PRK07220 598 DLMVRRSKRGSrFIGCEGYP-----ECTFSLPLPKSGQII-VTD------------KVCEAHG 642
|
|
| topB |
TIGR01056 |
DNA topoisomerase III, bacteria and conjugative plasmid; This model describes topoisomerase ... |
3-622 |
1.76e-67 |
|
DNA topoisomerase III, bacteria and conjugative plasmid; This model describes topoisomerase III from bacteria and its equivalents encoded on plasmids. The gene is designated topB if found in the bacterial chromosome, traE on conjugative plasmid RP4, etc. These enzymes are involved in the control of DNA topology. DNA topoisomerase III belongs to the type I topoisomerases, which are ATP-independent. [DNA metabolism, DNA replication, recombination, and repair]
Pssm-ID: 273419 [Multi-domain] Cd Length: 660 Bit Score: 237.43 E-value: 1.76e-67
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490999310 3 KALVIVESPAKAKTINKYL------------GNDYVVKSSVGHIRDLptsgsaskksadststkgaKKPKK-DERSALVn 69
Cdd:TIGR01056 1 MTLVLCEKPSQARDLATVLakkkkgngyleiGVGGFVTWAVGHLVEL-------------------AEPEEyDEKYKNW- 60
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490999310 70 RMGVDPWHDWDAQYEVLPGKEKVVSELKQL--AEKADHIYLATDLDREGEAIA-WHLREVIGGDEKRYSRVVFNEITKNA 146
Cdd:TIGR01056 61 RTYDLPLEPEDWQLVVSDKTKKQFNVIKRIlkENKVDEVVIATDPDREGELIArEILDYLKVTDKVTIKRLWISSLVDSS 140
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490999310 147 IRQAFDK--PGELNIDRVNAQQARRFMDRVVGYMVSPLLWKK-----IARGLSAGRVQSVAVRLVVEREREIKAFVPEEF 219
Cdd:TIGR01056 141 IRKAFKNlrPKSETEGLYKSGVARARADWLVGINLTRAFTKLgreagNDGVLSVGRVQTPTLAMVVKRENEIKNFVGKPF 220
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490999310 220 WEIDASTTTPgGDALPLQVTHKHDKPFRPVNRDETMAAVALLEKASYSVLEREDKPTSSKPGAPFITSTLQQAASTRLGF 299
Cdd:TIGR01056 221 YEVSATINKD-EQEFTTEWQPYKDEEERELHEFLAENVVTDLTQKPALVTDIEKERKKTSAPLFYDLSALQEDANKRFGI 299
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490999310 300 GVKKTMMMAQRLYEAG-YITYMRTDSTNLSQD-------ALSMVRGYIGDNFGKKYLPENANQYASKENSQEAHEAIRPS 371
Cdd:TIGR01056 300 SAKRTLDIAQKLYETHkLITYPRTDSRYLPEDekemlleVLDALKVITPALLPIKKRDELTNNRLWNDKKIEDHHAIIPT 379
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490999310 372 DVNVMAEDLKGMEAdalKLYQLIWRQFVACQMTPAQYDSTTLTVKAGDFKLKARGRTLRFDGWTKVMPALRKGDED--RT 449
Cdd:TIGR01056 380 GNDFNLSDLSEEER---NVYKLIAQNYLMQFMPKEEYETTTIEIAIGKLMFEAKGKILQDNGWKALLGKQEEDEETedTT 456
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490999310 450 LPVVNQGESLSLVELTPAQHFTKPPARFSEASLVKEL-----------------EKRGIGRPSTYASIISTIQDRGYVRV 512
Cdd:TIGR01056 457 LPAFQKGDELDVETLELLEKQTKPPARYTEGTLLSAMtnpaafvqdkglkktlkETKGLGTEATRADIIENLFKRGFIQK 536
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490999310 513 ENRRFYAEKMGEIVTDRLEEnfrDLMNYDFTAQMEDRLDQVANHQAEwrqvLDHFfgdFTTQLETAEKDPEEGGMQPNPM 592
Cdd:TIGR01056 537 KKNKIYITKNGKLLCLLLPE---LLTKPDLTAQWEQYLNGISAGEKD----DDDF---INTINEMIKQTINEEKKNPETI 606
|
650 660 670
....*....|....*....|....*....|
gi 490999310 593 VLTSIDCPTCGRQMGIRTASTGVFLGCSGY 622
Cdd:TIGR01056 607 QKVAKEPVSCGGIAKCPAKDNGRLIDCKKF 636
|
|
| PRK05776 |
PRK05776 |
DNA topoisomerase I; Provisional |
2-551 |
1.90e-67 |
|
DNA topoisomerase I; Provisional
Pssm-ID: 235602 [Multi-domain] Cd Length: 670 Bit Score: 237.58 E-value: 1.90e-67
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490999310 2 GKALVIVESPAKAKTIN--------------------KYLGNDYVVKSSVGHIRDLptsgsaskksadSTSTKGAkkPKK 61
Cdd:PRK05776 1 GYILVIAEKPKAARKIAealsekpircriygvpywivKRDGKKIVVAPAAGHLFGL------------HTKSKGF--PVF 66
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490999310 62 DersalvnrmgvdpwHDWDAQYEVLPGK---EKVVSELKQLAEKADHIYLATDLDREGEAIAWHLREVIGgDEKRYSRVV 138
Cdd:PRK05776 67 D--------------YEWKPLYEIDKGSkytKKYYELLSSLSKYADEFINACDYDIEGSVIGYLIIKYLG-DPKKAKRMK 131
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490999310 139 FNEITKNAIRQAFDKPGELNIDRVNAQQARRFMDRVVGYMVSPLLWK--KIARG----LSAGRVQSVAVRLVVEREREIK 212
Cdd:PRK05776 132 FSALTKSDIRRAFRNLETLDYEMINAGIARHELDWLWGINVSRALMSsvRDASGkrviLSAGRVQSPTLKYVVEREIERN 211
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490999310 213 AFVPEEFWEIDAsTTTPGGDALPLQVthkHDKPFRpvNRDETMAAVALLEKASY-SVLEREDKPTSSKPGAPFITSTLQQ 291
Cdd:PRK05776 212 LFVPLPYFSVSI-IIEKNGYEFTLKY---ENKKFE--TKEEAKEILEEIKKTGYlKVTKVEVKIEILEPPPPFNLGDLQV 285
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490999310 292 AASTRLGFGVKKTMMMAQRLYEAGYITYMRTDS-------------TNLSQdaLSMVRGYIGDNF---GKKYLPENAnqy 355
Cdd:PRK05776 286 EAARIYGFSPYKTQSIAEDLYLDGLISYPRTNSqklpptlnirnilKGLSR--SPQYRPLVNLLLketKGVLKPVQG--- 360
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490999310 356 aSKENSqeAHEAIRPSdvnvmAEDLKGMEADALKLYQLIWRQFVACQMTPAQYDSTTLTVKAGDF--KLKARGRTLRFDG 433
Cdd:PRK05776 361 -PKDDP--AHPAIYPT-----GEPPKNLSKDEFKLYDLIVRRFLASFAAPAVLSNTIVTLRVPGFplVFSASGQRIEERG 432
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490999310 434 WTKVMPaLRKGDEDrTLPVVNQGESLSLVELTPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVE 513
Cdd:PRK05776 433 WLKYYP-FHKFDEE-ELPLLKKGERVKIVDVKVRKSYTKPPSRYSKASLLKWMESVGIGTEATRARIIETLFKRGYLTSN 510
|
570 580 590
....*....|....*....|....*....|....*...
gi 490999310 514 NRRFYAEKMGEIVTDRLEENFRDLMNYDFTAQMEDRLD 551
Cdd:PRK05776 511 GKYIEVTPLGFGVAEVLEKYFPDIVSVELTRDFEEKLE 548
|
|
| COG1754 |
COG1754 |
Uncharacterized C-terminal domain of topoisomerase IA [Function unknown]; |
1-639 |
2.77e-65 |
|
Uncharacterized C-terminal domain of topoisomerase IA [Function unknown];
Pssm-ID: 441360 [Multi-domain] Cd Length: 892 Bit Score: 235.48 E-value: 2.77e-65
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490999310 1 MGKALVIVESPAKAKTINKYLGNDYVVKSSVGHIRDLPtsgsaskksadststkGAKKPKKDERSALVNRMGVDPWHDWD 80
Cdd:COG1754 3 AAVLVVVVVVVVKVPAAKKVLPKYAKKKKGVKAVLKKA----------------DVAKADDKVVDDDDKKDDVDDDKKKK 66
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490999310 81 AQYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIAWHLREVIGGDEKRYSRVVFNEITKNAIRQAFDKPGELNID 160
Cdd:COG1754 67 KKLLKAAAKKKKALALALAADDEDEELLAADDELEEEKVIKLLLLELAVERVARAAAVRAAAAEAARLAALLRRRLVLRR 146
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490999310 161 RVNAQQARRFMDRVVGYMVSPLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFVPEEFWEIDAsTTTPGGDALPLQVTH 240
Cdd:COG1754 147 LVRRLLVRLLLLRLVLLLLRLLVARRAARRRRRRRRRRARRRELERRRERARAAEAEEAAAAAA-AAADAGRAAAARDGK 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490999310 241 KHDKPFRPVNRDETMAAVALLEKASYSVLEREDKPTSSKPgAPFITSTLQQAASTRLGFGVKKTMMMAQR-------LYE 313
Cdd:COG1754 226 GGGKLAAGGAAAAAAAAAAAAAAAAALAEAAAAAAVREPP-TPTTTTTAQAATTTTTRAAAARTTRSAQQaarrtrlGGE 304
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490999310 314 AGYITYMRTDSTNLSQDALSMVRGYIGDNFGKKYLPENANQYASKENSQEAHEAIRPSDVNV---MAEDLKGMEADALKL 390
Cdd:COG1754 305 GTYTTTTTTTTTTSAAAAAAAAAAAALAAAAAAAYAPPPPYYYKKKAAAAAAAAAAAAAAAArrpPAARAALLSDDRLLL 384
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490999310 391 YQLIWRQFVACQMTPAQYDSTTLTVKA----GDFKLKARGRTLRFDGWTKVMPALRK---GDEDRTLPVVNQGESLSLVE 463
Cdd:COG1754 385 ELLLLRRTAAAAAAAAAATATTTAAAAaagaGAVGTAAAGAVFFFGGFLLFAEEEDDdeeDDDDDDLPALEEGLPLLKEG 464
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490999310 464 LTPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENRRFYAEKMGEIVTDRLEENFRDLMNYDFT 543
Cdd:COG1754 465 VLADQHFTQPPPRYTEAPLVKRMEELGIGRPSTYASILSTLADRIYVRLDKRRLIPEDKGRLVTAFLFSFFRRYVEYDFT 544
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490999310 544 AQMEDRLDQVANHQAEWRQVLDHFFGDFT-TQLETAEKDPEEGGMQPNpmVLTSID------CPTCGRQMGIRTASTGVF 616
Cdd:COG1754 545 ADLEEFLDDVSDGELDWKAVLRRFWRDFSaAYDETGDLRISEVLDALE--DLGEIDpreinsCPLGTGGLSLRVGRYGPF 622
|
650 660
....*....|....*....|....*...
gi 490999310 617 LGCSGYA-----LPPkerCKTTINLVPE 639
Cdd:COG1754 623 IECSNYEprrasIPE---CLAPDELTPE 647
|
|
| PRK14973 |
PRK14973 |
DNA topoisomerase I; Provisional |
87-634 |
3.36e-62 |
|
DNA topoisomerase I; Provisional
Pssm-ID: 184936 [Multi-domain] Cd Length: 936 Bit Score: 227.04 E-value: 3.36e-62
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490999310 87 PGKEKVVSELKQLAEKADHIYLATDLDREGEAIAWHLREVIGGDEK--RYSRVVFNEITKNAIRQAFDKPGELNIDRVNA 164
Cdd:PRK14973 81 PTEKKIVGLIQKLAKKADRVTIATDFDTEGELIGKEAYELVRAVNPkvPIDRARFSAITKEEIVTAFAEPTDLDFALAAA 160
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490999310 165 QQARRFMDRVVGYMVSPLLWKKIARG----LSAGRVQSVAVRLVVEREREIKAFVPEEFWEIDASTTTpggDALPLQVTH 240
Cdd:PRK14973 161 GEARQIIDLIWGASLTRFISLAAHRGgdniLSVGRVQSPTLAMIVDREKEIEAFVPEKYWMLSLATEK---DGEGIEARH 237
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490999310 241 KH----DKPFRPVNRDETMAAVALLEKASYSVLERedKPTsskpgaPFITSTLQQAAStRLGFGVKKTMMMAQRLYEAGY 316
Cdd:PRK14973 238 THgrftDSAAAEAAYDATKEPLVVTEVKEGHKVDR--APT------PFDTTTFIVAAS-RLGFSAANAMRIAEDLYMNGY 308
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490999310 317 ITYMRTDST-------------NLSQDALSMVRGYIGDNF------GKKylpenanqyaskenSQEAHEAIRPSDVNVMA 377
Cdd:PRK14973 309 ISYPRTDNTiypksldlngvlaTLAKGAFSKDVAWVKDNRrpvptrGKK--------------SSTDHPPIHPTGVATRE 374
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490999310 378 EdlkgMEADALKLYQLIWRQFVACQMTPAQYDSTTLTVKAGDFKLKARGRTLRFDGWTKVMPALRKgdEDRTLPVVNQGE 457
Cdd:PRK14973 375 E----LGDDRWKLYELVVRRFLATLSPDAEWATMKVNFDAGGEPYTATGGRLLEAGWRTVYPYSEA--KENILPAFALGE 448
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490999310 458 SLSLVELTPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYvrVENRRFYAEKMGEIVTDRLEENFRDL 537
Cdd:PRK14973 449 KLPILAVNLEEKETQPPARYSQSRLIQRMEELGLGTKSTRHEVIGKLVSRKY--IEGNPLRPTLVGRAVTESLEEHAGTI 526
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490999310 538 MNYDFTAQMEDRLDQVANHQ-------AEWRQVLDHFFgdftTQLETAEKDPEEGGMQPNPMVLTSIDCPTCGRQMGIRT 610
Cdd:PRK14973 527 TEPDMTQTLEEHMQQIKERKrtrddvvTESRKMLHRAF----DELEANEAVIGRDIMERTAEELTIGPCPVCGKDLRIKH 602
|
570 580
....*....|....*....|....
gi 490999310 611 ASTGVFLGCSGYalpPKERCKTTI 634
Cdd:PRK14973 603 IGSSQFIGCSGY---PDCTFNIGL 623
|
|
| TOPRIM_TopoIA_TopoI |
cd03363 |
TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TOPRIM) domain found in members of the type IA ... |
3-154 |
3.16e-59 |
|
TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TOPRIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving one strand of the DNA duplex, covalently linking to the 5' phosphoryl end of the DNA break and, allowing the other strand of the duplex to pass through the gap. The TOPRIM domain has two conserved motifs, one of which centers at a conserved glutamate and the other one at two conserved aspartates (DxD). For topoisomerases the conserved glutamate is believed to act as a general base in strand joining and, as a general acid in strand cleavage. The DXD motif may co-ordinate Mg2+, a cofactor required for full catalytic function.
Pssm-ID: 173783 [Multi-domain] Cd Length: 123 Bit Score: 197.40 E-value: 3.16e-59
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490999310 3 KALVIVESPAKAKTINKYLGNDYVVKSSVGHIRDLPTSGsaskksadststkgakkpkkdersalvnrMGVDPWHD-WDA 81
Cdd:cd03363 1 KKLVIVESPAKAKTIKKYLGKEYEVLASVGHIRDLPKKG-----------------------------LGVDGEDDgFEP 51
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 490999310 82 QYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIAWHLREVIGGDeKRYSRVVFNEITKNAIRQAFDKP 154
Cdd:cd03363 52 KYVVIPGKKKVVKELKKLAKKADEIYLATDPDREGEAIAWHLAEVLKLK-KNVKRVVFNEITKEAIKEALKNP 123
|
|
| YrdD |
COG0551 |
DNA topoisomerase I, ssDNA-binding Zn-finger and Zn-ribbon domains [Replication, recombination ... |
43-738 |
5.15e-53 |
|
DNA topoisomerase I, ssDNA-binding Zn-finger and Zn-ribbon domains [Replication, recombination and repair];
Pssm-ID: 440317 [Multi-domain] Cd Length: 695 Bit Score: 197.01 E-value: 5.15e-53
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490999310 43 ASKKSADSTSTKGAKKPKKDERSALVNRMGVDPWHDWDAQYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIAWH 122
Cdd:COG0551 22 KKKKKKEGKKKGLAGALGLKKKLVDLLLKEKLKKLVENEKLIAELDIKDLKKLKKDKKKKAKALAAALAAADDDAIEAAA 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490999310 123 LREVIGGDEKRYSRVVFNEITKNAIRQAFDKPGELNIDRVNAQQARRFMDRVVGYMVSPLLWKKIARGLSAGRVQSVAVR 202
Cdd:COG0551 102 AADEEEALKAAEALEAIRKAVVEEVKSRARKRAARAPADVAAAAAAAALARLLLLAAASRALRLLLLLAAGRLRLLSAVA 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490999310 203 LVVEREREIKAFVPEEFWEIDASTTTPGGDALPL---QVTHKHDKPFRPVNRDETMAAVALLEKASYSVLEREDKPTSSK 279
Cdd:COG0551 182 AGLLELEELLKEFEEEEEEEAAEEEEEEEEAKKKkeeDKKKKKKKKKKDKEEETKAIKKKKKAAEAVLAAKKAAKEAKAK 261
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490999310 280 PGAPFITSTLQQAASTRLGFGVKKTMMMAQRLYEA----------GYITYMRTDSTNLSQDALSMVRGYIGDNFGKKYLP 349
Cdd:COG0551 262 KELPTTTTDALPEALATTSLTAAAAASALAAALLEeegellytggYIRYTRTPKSSEADALAALEALKKIAEEPPDERAK 341
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490999310 350 ENANQYASKENSQEAHEAIRPSDVNVMAEDLKGMEADALKLYQ-LIWRQFVACQMTPAQYDSTTLTVKAGDFKLKARGRT 428
Cdd:COG0551 342 KKKKKAKKKKASEAKETTDHPPIPPTTAAALLELLEDRKLLLElLVRRRFAAAADLAKVEELTKVEEADEEELVEAEGGL 421
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490999310 429 LRFDGWTKVMPAlrKGDEDRTLPVVNQGESLSLVELTPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRG 508
Cdd:COG0551 422 LEVLGEEEEDDE--DEEEELLLPPLEEGEPLLLEELLLEKQTTTPPPRYTTELLLKKLEEEGGGGRGTTATIIILILKRR 499
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490999310 509 YVRVENRRFYAEKMGEIVTDRLEENFRDLMNYDFTAQMEDRLDQVANHQAEWRQVLDHFFGDFTTQLETAEKDPEEGGmQ 588
Cdd:COG0551 500 YVVLEEKKTTPTELLVEVVLLLLLPFPKLEDTTETAEEEEALLDKEEGKEDKVVEIREEEYPFFKKLLEIAEEEGEEE-L 578
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490999310 589 PNPMVLTSIDCPTCGRQMGIRTASTGVFLGCSGYalpPKerCKTTINLvPENEVLNVlegddaetnalrakrRCQKCGTA 668
Cdd:COG0551 579 SEEDEVLGEKCPKCGKPLVIKKGRYGKFLGCSNY---PE--CKYTKPL-PKPEVTGV---------------KCPKCGKK 637
|
650 660 670 680 690 700 710
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 490999310 669 MDsyLIDPK--RKLHVCGNNPTCDgyeieegeFRIKgyDGPV-VECEKCGSEMHLKMGRFGkymaCTNDECKN 738
Cdd:COG0551 638 LV--LRKSKkgKVFYGCSNYPKCK--------FTEW--DKPVkEPCPKCGSPLVEKKTKKG----CANKLCGY 694
|
|
| PTZ00407 |
PTZ00407 |
DNA topoisomerase IA; Provisional |
5-554 |
9.31e-51 |
|
DNA topoisomerase IA; Provisional
Pssm-ID: 173597 [Multi-domain] Cd Length: 805 Bit Score: 191.69 E-value: 9.31e-51
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490999310 5 LVIVESPAKAKTINKYLGNDYVVKS---SVGHIRDLPTSgsASKKSADST-----STKGAKKPKKDERSALVNRMGVDPW 76
Cdd:PTZ00407 12 LVIVESPNKVIKVEGLLSDPKVIPDwsfKQSHLRRIGTG--AEKAVAMATtghfmALKEITWSPQASSPASVVGAGDEPF 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490999310 77 H------DWDAQYEVLPGK---EKVVSELKQLAEKADHIYLATDLDREGEAIAWHLREVIggdeKR--------YSRVVF 139
Cdd:PTZ00407 90 PsngtlaEYTLEWELLPGRriqETLERYIEEKADNVTEIILATDPDREGELIAVHALQTI----KRlypklkvpFSRAYM 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490999310 140 NEITKNAIRQAFDK--PGELNIDRVNAQQARRFMDRVVGYMVSPLLWKKIARGLSAGRVQSVAVRLVVEREREIKAFvpe 217
Cdd:PTZ00407 166 HSITEDGIRKAMRErhVEACDYDLANAAETRHAMDRIFGFLGSSVVRAANSQMRSIGRVQTPALILINEREDKIKAF--- 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490999310 218 efweIDASTTTPGGDALpLQVTHKHDKPFRPVN-------------RDETMAAVAL----LEKASYSVLEREDKPTSSK- 279
Cdd:PTZ00407 243 ----LESNKSTFEVQAM-CQFPSPHGTTFSQVVtitpdrkggashwATEAEARRCLeqwkLNNCTGFSVPLEPKPQPSVv 317
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490999310 280 -PGAPFITSTLQQAASTRLGFGVKKTMMMAQRLYEAGYITYMRTDSTNLSQDALSMVRGYIGDNFGKKYLPENANQYASK 358
Cdd:PTZ00407 318 pPPQPFTMATAIAKANRQLKYSSEMVSGCLQDLFQLGHITYPRTDSTRIDESALPDIYAAVKKEFGKEFLYRLEDRTVSA 397
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490999310 359 E-------------------------NSQEAHEAIRPSDVNVMAEDLkGMEADALKLYQLIWRQFVACQMTPAQYDSTTL 413
Cdd:PTZ00407 398 QegkgskktgkkrstkqkkgadtpvgNVEDAHEAIRPTNIDTTGESL-SLSPPTRAVYDLVRRNTLAVFMIPMKTEKIVA 476
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490999310 414 TVK----AGD-FKLKARGRTLRFDGWTKvmpALRKGDEDRTLPVV----------------------------------- 453
Cdd:PTZ00407 477 TVKftsgSGEkLEFELQGKRVVEPGWTR---AFHKGDKGTTGPAEetdeditaveegapvvpslsqeefkaimnlrsqlg 553
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490999310 454 --NQGESLSLVELTPAQHFTKPPARFSEASLVKELEKRGIGRPSTYASIISTIQDRGYVRVENR-RFYAEKMGEIVTDRL 530
Cdd:PTZ00407 554 sgVQKGFFELRSPQVRENRPVPPLPHSEGTLIEELKNNGVGRPSTYPMIVKTLLARGYIAVNPKgRCETTPVGRMLVETA 633
|
650 660
....*....|....*....|....
gi 490999310 531 EENFRDLMNYDFTAQMEDRLDQVA 554
Cdd:PTZ00407 634 KSTFPSIVDIGFTAAFEKKLDRIA 657
|
|
| TOPRIM_TopoIA |
cd01028 |
TOPRIM_TopoIA: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the ... |
3-154 |
5.38e-44 |
|
TOPRIM_TopoIA: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in the type IA family of DNA topoisomerases (TopoIA). This subgroup contains proteins similar to the Type I DNA topoisomerases: E. coli topisomerases I and III, eukaryotic topoisomerase III and, ATP-dependent reverse gyrase found in archaea and thermophilic bacteria. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA. These enzymes cleave one strand of the DNA duplex, covalently link to the 5' phosphoryl end of the DNA break and allow the other strand of the duplex to pass through the gap. Reverse gyrase is also able to insert positive supercoils in the presence of ATP and negative supercoils in the presence of AMPPNP. The TOPRIM domain has two conserved motifs, one of which centers at a conserved glutamate and the other one at two conserved aspartates (DxD). For topoisomerases the conserved glutamate is believed to act as a general base in strand joining and, as a general acid in strand cleavage. The DXD motif may co-ordinate Mg2+, a cofactor required for full catalytic function.
Pssm-ID: 173778 [Multi-domain] Cd Length: 142 Bit Score: 155.46 E-value: 5.38e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490999310 3 KALVIVESPAKAKTINKYLGN------------DYVVKSSVGHIRDLPTSGsaskksadststKGAKKPKKDERsalvnr 70
Cdd:cd01028 1 KVLIIAEKPSKAKTIAKILGKgskkkgfygeggGYVVTASVGHLLELPFPE------------EYVDWDKDWPL------ 62
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490999310 71 mgvdPWHDWDAQYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIAWHLREVIGGDEKRYSRVVFNEITKNAIRQA 150
Cdd:cd01028 63 ----ELFPFEPKYVVIPDKKKQLKALKKLAKKADEIVLATDPDREGELIAWEILEVLKCDNKPVKRAWFSEITPKAIREA 138
|
....
gi 490999310 151 FDKP 154
Cdd:cd01028 139 FKNL 142
|
|
| TOP1Bc |
smart00436 |
Bacterial DNA topoisomeraes I ATP-binding domain; Extension of TOPRIM in Bacterial DNA ... |
134-221 |
1.53e-42 |
|
Bacterial DNA topoisomeraes I ATP-binding domain; Extension of TOPRIM in Bacterial DNA topoisomeraes I and III, Eukaryotic DNA topoisomeraes III, reverse gyrase beta subunit
Pssm-ID: 214662 [Multi-domain] Cd Length: 89 Bit Score: 149.27 E-value: 1.53e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490999310 134 YSRVVFNEITKNAIRQAFDKPGELNIDRVNAQQARRFMDRVVGYMVSPLLWKKIAR-GLSAGRVQSVAVRLVVEREREIK 212
Cdd:smart00436 1 IKRIEFSEITKKAIREALKNPREIDENLVNAQLARRILDRLIGFNLSRLLTKKLRNgVLSAGRVQTPTLGLIVEREREIK 80
|
....*....
gi 490999310 213 AFVPEEFWE 221
Cdd:smart00436 81 NFVPKPYWE 89
|
|
| PRK08173 |
PRK08173 |
DNA topoisomerase III; Validated |
1-515 |
4.03e-41 |
|
DNA topoisomerase III; Validated
Pssm-ID: 236172 [Multi-domain] Cd Length: 862 Bit Score: 162.91 E-value: 4.03e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490999310 1 MGKALVIVESPAKAKTINKYLG-----------NDYVVKSSVGHIRDLptsgsaskksadststkgaKKPKKDErsalVN 69
Cdd:PRK08173 1 MSKALIIAEKPSVANDIARALGgftkhdeyfesDEYVLSSAVGHLLEI-------------------AAPEEYE----VK 57
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490999310 70 RmgvdpwHDWD-AQYEVLPGK------EKVVSELKQLAEKA-----DHIYLATDLDREGEAIAWHLREVIGGDeKRYSRV 137
Cdd:PRK08173 58 R------GKWSfAHLPVIPPHfdlnpiAKTESRLKVLTKLIkrkdvTRLINACDAGREGELIFRLIAQHAKAK-KPVKRL 130
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490999310 138 VFNEITKNAIRQAFDK--PGELNIDRVNAQQARRFMDRVVGYMVSpllwkkiaRGLSA-------------GRVQSVAVR 202
Cdd:PRK08173 131 WLQSMTPQAIRDGFANlrSDEDMQPLADAARCRSEADWLVGINGT--------RAMTAfnskgggfflttvGRVQTPTLS 202
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490999310 203 LVVEREREIKAFVPEEFWEIDASTTTPGGD--------ALPLQVTHKHDKPFRPVNRDETMAAVALLEKASYSVLErEDK 274
Cdd:PRK08173 203 IVVEREEKIRRFVPRDYWEVRAEFVAAAGFyegrwfdpKFKKDEFDPEKRASRLWSEAAAEAIVAACRGKPGTVTE-ESK 281
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490999310 275 PTSSKPGAPFITSTLQQAASTRLGFGVKKTMMMAQRLYEA-GYITYMRTDSTNLSQDALSMVR---GYIGDNFGkkYLPe 350
Cdd:PRK08173 282 PSTQLSPLLFDLTSLQREANGRFGFSAKNTLGLAQALYEKhKVLTYPRTDSRALPEDYLGTVKqtlEMLKESNN--YLP- 358
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490999310 351 NANQYASK----------ENSQEA-HEAIRPSdvNVMAEDLKGMEAdalKLYQLIWRQFVACQMTPAQYDSTTLTVKAGD 419
Cdd:PRK08173 359 HAKQILDKgwvkpnkrifDNSKISdHFAIIPT--LQAPKSLSEPEQ---KLYDLVVKRFLAVFFPAAEFLVTTRITEVAG 433
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490999310 420 FKLKARGRTLRFDGWTKVMpALRKGDEDRTLPVVNQGESLSLVELTPAQHFTKPPARFSEASLVKELE------------ 487
Cdd:PRK08173 434 HHFKTEGKVLVNPGWLAVY-GKEAQGADANLVPVQKGEKVKTDKIEAVALTTKPPARYNEATLLSAMEgagklveddelr 512
|
570 580 590
....*....|....*....|....*....|..
gi 490999310 488 ----KRGIGRPSTYASIISTIQDRGYVRVENR 515
Cdd:PRK08173 513 eamaEKGLGTPATRAAIIEGLLGEKYLVREGR 544
|
|
| PRK14724 |
PRK14724 |
DNA topoisomerase III; Provisional |
3-603 |
2.14e-35 |
|
DNA topoisomerase III; Provisional
Pssm-ID: 237803 [Multi-domain] Cd Length: 987 Bit Score: 145.10 E-value: 2.14e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490999310 3 KALVIVESPAKAKTI--------------NKYLGND-YVVKSSVGHIRDLptsgsaskKSADSTSTKGAKkpkkderSAL 67
Cdd:PRK14724 2 KTLVIAEKPSVAQDIvraltpvagkfekhDEHFESDsYVVTSAVGHLVEI--------QAPEEFDVKRGK-------WSF 66
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490999310 68 VNRMGVDPWHDwdaqyevLPGKEKVVSELK---QLAEKADHIYL--ATDLDREGEAIAWHLREVIGGDE----KRYSRVV 138
Cdd:PRK14724 67 ANLPVIPPYFD-------LKPVDKTKTRLNavvKLAKRKDVTELvnACDAGREGELIFRLIEQYAGGAKgglgKPVKRLW 139
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490999310 139 FNEITKNAIRQAFD--KPGELNIDRVNAQQARRFMDRVVGYMVSPLLWKKIARG-----LSAGRVQSVAVRLVVEREREI 211
Cdd:PRK14724 140 LQSMTPQAIRDGFDnlRSDAQMQGLASAARSRSEADWLVGINGTRAMTAFNSRDggfflTTVGRVQTPTLSLVVEREEKI 219
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490999310 212 KAFVPEEFWEIDASTTTPGGDALPLQVTHKHDKPF--------RPVNRDETMAAVALLEKASYSVLErEDKPTSSKPGAP 283
Cdd:PRK14724 220 RKFVSRDYWEIHAGFHAEAGEYLGKWFDPQWKKASddpearadRVWSEREARAIADAVRGKAATVTE-ESKPTTQASPLL 298
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490999310 284 FITSTLQQAASTRLGFGVKKTMMMAQRLYEA-GYITYMRTDSTNLSQDALSMVRGYIG--DNFGKKYLPENANQ------ 354
Cdd:PRK14724 299 FDLTSLQREANGKFGFSAKTTLALAQSLYERhKALTYPRTDSRALPEDYLPVAKQTFEmlATSGMRHLAPFAQQaldgny 378
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490999310 355 -YASK---ENSQEA-HEAIRPSdvnvmAEDLKGMEADALKLYQLIWRQFVACQMTPAQYDSTTLTVKAGDFKLKARGRTL 429
Cdd:PRK14724 379 vRPSKrifDNSKVSdHFAIIPT-----TQAPSGLSEAEQKLYDLVVRRFMAVFFPSAEYQVTTRISQVVGHSFKTEGKVL 453
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490999310 430 RFDGWTKV--------MPALRKGDEDRTLPVVNQGESLSLVELTPAQHFTKPPARFSEASLVKELE-------------- 487
Cdd:PRK14724 454 VKPGWLAIygkeaaneVEDAKDGDKGQPLVPVKPGEMVRTEFAEAKGLKTKPPARYSEATLLGAMEsagkqidddelrea 533
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490999310 488 --KRGIGRPSTYASIISTIQDRGYVRVENRRFY-AEKMGEIVTDRLEENFRDLMNYDFTAQMEDRLDQVANHQAEwRQVL 564
Cdd:PRK14724 534 mqEKGLGTPATRAAIIEGLLTEKYMLREGRELIpTAKAFQLMTLLRGLGVEELSRAELTGEWEYKLAQMEKGQLS-REAF 612
|
650 660 670
....*....|....*....|....*....|....*....
gi 490999310 565 DHFFGDFTTQLETAEKDPEEGGMqPNPMVLTSIDCPTCG 603
Cdd:PRK14724 613 MQQIAAMTEKLVKKAKEYDRDTI-PGDYATLSTPCPNCG 650
|
|
| TOPRIM_TopoIA_TopoIII |
cd03362 |
TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type ... |
3-154 |
1.08e-21 |
|
TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving one strand of the DNA duplex, covalently linking to the 5' phosphoryl end of the DNA break and, allowing the other strand of the duplex to pass through the gap. The TOPRIM domain has two conserved motifs, one of which centers at a conserved glutamate and the other one at two conserved aspartates (DxD). For topoisomerases the conserved glutamate is believed to act as a general base in strand joining and, as a general acid in strand cleavage. The DXD motif may co-ordinate Mg2+, a cofactor required for full catalytic function.
Pssm-ID: 173782 [Multi-domain] Cd Length: 151 Bit Score: 92.30 E-value: 1.08e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490999310 3 KALVIVESPAKAKTI------------------NKYLGNDYVVKSSVGHIRDLptsgsaskksadststkgakkpkkDER 64
Cdd:cd03362 1 MVLIIAEKPSVAKAIakilgggskkkgkgryyeFYGEGGGYVVTWASGHLLEL------------------------DFP 56
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490999310 65 SALVNRMGVDPWHD----WDAQYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIAWHLREVIG-GDEKRYSRVVF 139
Cdd:cd03362 57 EEYDPWDKVWPLEDplfpAPFKLKVDKGKKKQFKVLKKLAKRADEIVIATDADREGELIGREILEYAKcVKRKPVKRAWF 136
|
170
....*....|....*
gi 490999310 140 NEITKNAIRQAFDKP 154
Cdd:cd03362 137 SSLTPKAIRRAFKNL 151
|
|
| Topo_Zn_Ribbon |
pfam08272 |
Topoisomerase I zinc-ribbon-like; Some Proteobacteria topoisomerase I contain two ... |
824-862 |
8.42e-21 |
|
Topoisomerase I zinc-ribbon-like; Some Proteobacteria topoisomerase I contain two zinc-ribbon-like domains at the C-terminus that structurally homologous to pfam01396. However, this domain no longer bind zinc. Indeed, only one of the four cysteine residues remains.
Pssm-ID: 462415 [Multi-domain] Cd Length: 39 Bit Score: 85.79 E-value: 8.42e-21
10 20 30
....*....|....*....|....*....|....*....
gi 490999310 824 GNKTLVRFSRKTKQQYVASEKDGKATGWSAFYIDGKWTE 862
Cdd:pfam08272 1 GNPALVRFSRKTKEQYVLSEVDGKATGWLAAYTDGKWRE 39
|
|
| Toprim |
pfam01751 |
Toprim domain; This is a conserved region from DNA primase. This corresponds to the Toprim ... |
4-142 |
2.44e-19 |
|
Toprim domain; This is a conserved region from DNA primase. This corresponds to the Toprim domain common to DnaG primases, topoisomerases, OLD family nucleases and RecR proteins. Both DnaG motifs IV and V are present in the alignment, the DxD (V) motif may be involved in Mg2+ binding and mutations to the conserved glutamate (IV) completely abolish DnaG type primase activity. DNA primase EC:2.7.7.6 is a nucleotidyltransferase it synthesizes the oligoribonucleotide primers required for DNA replication on the lagging strand of the replication fork; it can also prime the leading stand and has been implicated in cell division. This family also includes the atypical archaeal A subunit from type II DNA topoisomerases. Type II DNA topoisomerases catalyze the relaxation of DNA supercoiling by causing transient double strand breaks.
Pssm-ID: 396354 [Multi-domain] Cd Length: 93 Bit Score: 83.56 E-value: 2.44e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490999310 4 ALVIVESPAKAKTINKYLG-NDYVVKSSVGHIRDLPTsgsaskksadststkgakkpkkdersalvnrmgvdpwhdwdaq 82
Cdd:pfam01751 1 ELIIVEGPSDAIALEKALGgGFQAVVAVLGHLLSLEK------------------------------------------- 37
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|
gi 490999310 83 yevlPGKEKVVSELKQLAEKADHIYLATDLDREGEAIAWHLREVIGGDEKRYSRVVFNEI 142
Cdd:pfam01751 38 ----GPKKKALKALKELALKAKEVILATDPDREGEAIALKLLELKELLENAGGRVEFSEL 93
|
|
| TOPRIM_TopoIA_RevGyr |
cd03361 |
TopoIA_RevGyr : The topoisomerase-primase (TORPIM) domain found in members of the type IA ... |
4-154 |
5.42e-17 |
|
TopoIA_RevGyr : The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to the ATP-dependent reverse gyrase found in archaea and thermophilic bacteria. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving one strand of the DNA duplex, covalently linking to the 5' phosphoryl end of the DNA break and, allowing the other strand of the duplex to pass through the gap. Reverse gyrase is also able to insert positive supercoils in the presence of ATP and negative supercoils in the presence of AMPPNP. The TOPRIM domain has two conserved motifs, one of which centers at a conserved glutamate and the other one at two conserved aspartates (DxD). For topoisomerases the conserved glutamate is believed to act as a general base in strand joining and, as a general acid in strand cleavage. The DXD motif may co-ordinate Mg2+, a cofactor required for full catalytic function.
Pssm-ID: 173781 [Multi-domain] Cd Length: 170 Bit Score: 79.28 E-value: 5.42e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490999310 4 ALVIVESPAKAKTINKYLG-----------------NDYV--VKSSVGHIRDLPTSGSASKKSADststKGAKKP----- 59
Cdd:cd03361 2 ALMIVESPNKARTIANFFGrpsvrrlgglvvyevstGDGVlmITASGGHVYDLVTKEGGHGVVED----DGRYVPvydsi 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490999310 60 KK--DERSALVNRMGVDPwhdwDAQYEVLPGKEKVVSELKQLAEKADHIYLATDLDREGEAIAWHLREVIGGDEKRYSRV 137
Cdd:cd03361 78 KRcrDCGYQFTEDSDKCP----RCGSENIDDKLETLEALRELALEVDEVLIATDPDTEGEKIAWDVYLALRPYNKNIKRA 153
|
170
....*....|....*..
gi 490999310 138 VFNEITKNAIRQAFDKP 154
Cdd:cd03361 154 EFHEVTRRAILEALRNP 170
|
|
| TOPRIM |
smart00493 |
topoisomerases, DnaG-type primases, OLD family nucleases and RecR proteins; |
3-130 |
3.74e-15 |
|
topoisomerases, DnaG-type primases, OLD family nucleases and RecR proteins;
Pssm-ID: 214695 [Multi-domain] Cd Length: 75 Bit Score: 70.75 E-value: 3.74e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490999310 3 KALVIVESPAKAKTINKYLGNDYVVKSSVGHIRdlptsgsaskksadststkgakkpkkdersalvnrmgvdpwhdwdaq 82
Cdd:smart00493 1 KVLIIVEGPADAIALEKAGGKRGNVVALGGHLL----------------------------------------------- 33
|
90 100 110 120
....*....|....*....|....*....|....*....|....*...
gi 490999310 83 yevlpgKEKVVSELKQLAEKAdHIYLATDLDREGEAIAWHLREVIGGD 130
Cdd:smart00493 34 ------SKEQIKLLKKLAKKA-EVILATDPDREGEAIAWELAELLKPA 74
|
|
| zf-C4_Topoisom |
pfam01396 |
Topoisomerase DNA binding C4 zinc finger; |
708-745 |
8.42e-13 |
|
Topoisomerase DNA binding C4 zinc finger;
Pssm-ID: 307520 [Multi-domain] Cd Length: 39 Bit Score: 63.05 E-value: 8.42e-13
10 20 30
....*....|....*....|....*....|....*....
gi 490999310 708 VVECEKCGSEMHLKMGRFGKYMACTN-DECKNTRKILRN 745
Cdd:pfam01396 1 GGKCPKCGGDLVLKRGRFGKFVGCSNyPECRFTRPLKKN 39
|
|
| TOPRIM |
cd00188 |
Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type ... |
3-139 |
5.78e-11 |
|
Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from bacterial and archaea, and bacterial DNA repair proteins of the RecR/M family. This domain has two conserved motifs, one of which centers at a conserved glutamate and the other one at two conserved aspartates (DxD). This glutamate and two aspartates, cluster together to form a highly acid surface patch. The conserved glutamate may act as a general base in nucleotide polymerization by primases and in strand joining in topoisomerases and, as a general acid in strand cleavage by topisomerases and nucleases. The DXD motif may co-ordinate Mg2+, a cofactor required for full catalytic function.
Pssm-ID: 173773 [Multi-domain] Cd Length: 83 Bit Score: 59.36 E-value: 5.78e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490999310 3 KALVIVESPAKAKTINKYLGNDYVVKSSVGHIRdlptsgsaskksadststkgakkpkkdersalvnrmgvdpwhdwdaq 82
Cdd:cd00188 1 KKLIIVEGPSDALALAQAGGYGGAVVALGGHAL----------------------------------------------- 33
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*..
gi 490999310 83 yevlpgkEKVVSELKQLAEKADHIYLATDLDREGEAIAWHLREVIGGDEKRYSRVVF 139
Cdd:cd00188 34 -------NKTRELLKRLLGEAKEVIIATDADREGEAIALRLLELLKSLGKKVRRLLL 83
|
|
| Topo_Zn_Ribbon |
pfam08272 |
Topoisomerase I zinc-ribbon-like; Some Proteobacteria topoisomerase I contain two ... |
757-791 |
6.54e-07 |
|
Topoisomerase I zinc-ribbon-like; Some Proteobacteria topoisomerase I contain two zinc-ribbon-like domains at the C-terminus that structurally homologous to pfam01396. However, this domain no longer bind zinc. Indeed, only one of the four cysteine residues remains.
Pssm-ID: 462415 [Multi-domain] Cd Length: 39 Bit Score: 46.50 E-value: 6.54e-07
10 20 30
....*....|....*....|....*....|....*....
gi 490999310 757 PLPELP--CEKSDAFFVLR--DGAAGVFLAANTFPKSRE 791
Cdd:pfam08272 1 GNPALVrfSRKTKEQYVLSevDGKATGWLAAYTDGKWRE 39
|
|
| zf-C4_Topoisom |
pfam01396 |
Topoisomerase DNA binding C4 zinc finger; |
597-638 |
1.09e-04 |
|
Topoisomerase DNA binding C4 zinc finger;
Pssm-ID: 307520 [Multi-domain] Cd Length: 39 Bit Score: 40.32 E-value: 1.09e-04
10 20 30 40
....*....|....*....|....*....|....*....|..
gi 490999310 597 IDCPTCGRQMGIRTASTGVFLGCSGYalpPKerCKTTINLVP 638
Cdd:pfam01396 2 GKCPKCGGDLVLKRGRFGKFVGCSNY---PE--CRFTRPLKK 38
|
|
| |
