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Conserved domains on  [gi|490986541|ref|WP_004848274|]
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MULTISPECIES: Lrp/AsnC family transcriptional regulator [Klebsiella]

Protein Classification

Lrp/AsnC family transcriptional regulator( domain architecture ID 11445815)

Lrp/AsnC (leucine-responsive regulatory protein/asparagine synthase C) family transcriptional regulator regulates many cellular processes such as amino acid metabolism, pili synthesis, and DNA repair and recombination

CATH:  3.30.70.920|1.10.10.10
Gene Ontology:  GO:0043565
PubMed:  16438681|21608015|27206730

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Lrp COG1522
DNA-binding transcriptional regulator, Lrp family [Transcription];
1-140 5.83e-51

DNA-binding transcriptional regulator, Lrp family [Transcription];


:

Pssm-ID: 441131 [Multi-domain]  Cd Length: 138  Bit Score: 159.17  E-value: 5.83e-51
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490986541   1 MLDKIDRKLLSLLQTDCTLSLQALADAVNLTTTPCWKRLKRLEDEGILCGRVALLDAEKVGLGLTAFVLIKTQHHSSDwy 80
Cdd:COG1522    2 ELDEIDRRILRLLQEDGRLSFAELAERVGLSESTVLRRVRRLEEAGVIRGYGAVVDPEKLGLGVTAFVEVKVPPHRLD-- 79

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 490986541  81 cRFVSEVTQMAEVLGFWRMAGEYDYLLRVQVADMKNYDDFYKRLVNSVPGLSDVTSSFAM 140
Cdd:COG1522   80 -EFAEALAAIPEVLECYLVTGDYDLLLKVVARDMEELERFLLERLAALPGVRRTETSFVL 138
 
Name Accession Description Interval E-value
Lrp COG1522
DNA-binding transcriptional regulator, Lrp family [Transcription];
1-140 5.83e-51

DNA-binding transcriptional regulator, Lrp family [Transcription];


Pssm-ID: 441131 [Multi-domain]  Cd Length: 138  Bit Score: 159.17  E-value: 5.83e-51
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490986541   1 MLDKIDRKLLSLLQTDCTLSLQALADAVNLTTTPCWKRLKRLEDEGILCGRVALLDAEKVGLGLTAFVLIKTQHHSSDwy 80
Cdd:COG1522    2 ELDEIDRRILRLLQEDGRLSFAELAERVGLSESTVLRRVRRLEEAGVIRGYGAVVDPEKLGLGVTAFVEVKVPPHRLD-- 79

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 490986541  81 cRFVSEVTQMAEVLGFWRMAGEYDYLLRVQVADMKNYDDFYKRLVNSVPGLSDVTSSFAM 140
Cdd:COG1522   80 -EFAEALAAIPEVLECYLVTGDYDLLLKVVARDMEELERFLLERLAALPGVRRTETSFVL 138
HTH_ASNC smart00344
helix_turn_helix ASNC type; AsnC: an autogenously regulated activator of asparagine synthetase ...
 2-111 2.38e-33

helix_turn_helix ASNC type; AsnC: an autogenously regulated activator of asparagine synthetase A transcription in Escherichia coli)


Pssm-ID: 214628 [Multi-domain]  Cd Length: 108  Bit Score: 113.38  E-value: 2.38e-33
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490986541     2 LDKIDRKLLSLLQTDCTLSLQALADAVNLTTTPCWKRLKRLEDEGILCGRVALLDAEKVGLGLTAFVLIKTqhHSSDWYC 81
Cdd:smart00344   1 LDEIDRKILEELQKDARISLAELAKKVGLSPSTVHNRVKRLEEEGVIKGYTAVLNPKKLGLSVTAFVGVTL--ENPDKLE 78

                           90       100       110
                   ....*....|....*....|....*....|
gi 490986541    82 RFVSEVTQMAEVLGFWRMAGEYDYLLRVQV 111
Cdd:smart00344  79 EFLEKLEKLPEVEEVYLVTGDYDYLLKVRA 108
PRK11169 PRK11169
leucine-responsive transcriptional regulator Lrp;
2-151 2.00e-26

leucine-responsive transcriptional regulator Lrp;


Pssm-ID: 183009 [Multi-domain]  Cd Length: 164  Bit Score: 97.52  E-value: 2.00e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490986541   2 LDKIDRKLLSLLQTDCTLSLQALADAVNLTTTPCWKRLKRLEDEGILCGRVALLDAEKVGLGLTAFVLIKTQHHSSDWYC 81
Cdd:PRK11169  12 LDRIDRNILNELQKDGRISNVELSKRVGLSPTPCLERVRRLERQGFIQGYTALLNPHYLDASLLVFVEITLNRGAPDVFE 91

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490986541  82 RFVSEVTQMAEVLGFWRMAGEYDYLLRVQVADMKNYDDFYKRLVNSVPGLSDVTSSFAMEQIKYTTALPI 151
Cdd:PRK11169  92 QFNAAVQKLEEIQECHLVSGDFDYLLKTRVPDMSAYRKLLGETLLRLPGVNDTRTYVVMEEVKQTNRLVI 161
AsnC_trans_reg pfam01037
Lrp/AsnC ligand binding domain; The l-leucine-responsive regulatory protein (Lrp/AsnC) family ...
 68-142 6.58e-20

Lrp/AsnC ligand binding domain; The l-leucine-responsive regulatory protein (Lrp/AsnC) family is a family of similar bacterial transcription regulatory proteins. The family is named after two E. coli proteins involved in regulating amino acid metabolism. This entry corresponds to the usually C-terminal regulatory ligand binding domain. Structurally this domain has a dimeric alpha/beta barrel fold. This domain binds almost exclusively amino acids but also 4-hydroxyphenylpyruvate and kynurenine (Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).


Pssm-ID: 426007  Cd Length: 73  Bit Score: 77.95  E-value: 6.58e-20
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 490986541   68 VLIKTQHHSsdWYCRFVSEVTQMAEVLGFWRMAGEYDYLLRVQVADMKNYDDFYKRLVNSVPGLSDVTSSFAMEQ 142
Cdd:pfam01037   1 VEVKLEPGH--ALEEFAEALAAIPEVVECYRVTGDYDYLLKVVARDLEALERFLREKLRSLPGVARTETSIVLST 73
HTH_ARSR cd00090
Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric ...
 1-51 1.29e-04

Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.


Pssm-ID: 238042 [Multi-domain]  Cd Length: 78  Bit Score: 38.43  E-value: 1.29e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|.
gi 490986541   1 MLDKIDRKLLSLLQTDCtLSLQALADAVNLTTTPCWKRLKRLEDEGILCGR 51
Cdd:cd00090    4 LSDPTRLRILRLLLEGP-LTVSELAERLGLSQSTVSRHLKKLEEAGLVESR 53
 
Name Accession Description Interval E-value
Lrp COG1522
DNA-binding transcriptional regulator, Lrp family [Transcription];
1-140 5.83e-51

DNA-binding transcriptional regulator, Lrp family [Transcription];


Pssm-ID: 441131 [Multi-domain]  Cd Length: 138  Bit Score: 159.17  E-value: 5.83e-51
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490986541   1 MLDKIDRKLLSLLQTDCTLSLQALADAVNLTTTPCWKRLKRLEDEGILCGRVALLDAEKVGLGLTAFVLIKTQHHSSDwy 80
Cdd:COG1522    2 ELDEIDRRILRLLQEDGRLSFAELAERVGLSESTVLRRVRRLEEAGVIRGYGAVVDPEKLGLGVTAFVEVKVPPHRLD-- 79

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 490986541  81 cRFVSEVTQMAEVLGFWRMAGEYDYLLRVQVADMKNYDDFYKRLVNSVPGLSDVTSSFAM 140
Cdd:COG1522   80 -EFAEALAAIPEVLECYLVTGDYDLLLKVVARDMEELERFLLERLAALPGVRRTETSFVL 138
HTH_ASNC smart00344
helix_turn_helix ASNC type; AsnC: an autogenously regulated activator of asparagine synthetase ...
 2-111 2.38e-33

helix_turn_helix ASNC type; AsnC: an autogenously regulated activator of asparagine synthetase A transcription in Escherichia coli)


Pssm-ID: 214628 [Multi-domain]  Cd Length: 108  Bit Score: 113.38  E-value: 2.38e-33
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490986541     2 LDKIDRKLLSLLQTDCTLSLQALADAVNLTTTPCWKRLKRLEDEGILCGRVALLDAEKVGLGLTAFVLIKTqhHSSDWYC 81
Cdd:smart00344   1 LDEIDRKILEELQKDARISLAELAKKVGLSPSTVHNRVKRLEEEGVIKGYTAVLNPKKLGLSVTAFVGVTL--ENPDKLE 78

                           90       100       110
                   ....*....|....*....|....*....|
gi 490986541    82 RFVSEVTQMAEVLGFWRMAGEYDYLLRVQV 111
Cdd:smart00344  79 EFLEKLEKLPEVEEVYLVTGDYDYLLKVRA 108
PRK11169 PRK11169
leucine-responsive transcriptional regulator Lrp;
2-151 2.00e-26

leucine-responsive transcriptional regulator Lrp;


Pssm-ID: 183009 [Multi-domain]  Cd Length: 164  Bit Score: 97.52  E-value: 2.00e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490986541   2 LDKIDRKLLSLLQTDCTLSLQALADAVNLTTTPCWKRLKRLEDEGILCGRVALLDAEKVGLGLTAFVLIKTQHHSSDWYC 81
Cdd:PRK11169  12 LDRIDRNILNELQKDGRISNVELSKRVGLSPTPCLERVRRLERQGFIQGYTALLNPHYLDASLLVFVEITLNRGAPDVFE 91

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490986541  82 RFVSEVTQMAEVLGFWRMAGEYDYLLRVQVADMKNYDDFYKRLVNSVPGLSDVTSSFAMEQIKYTTALPI 151
Cdd:PRK11169  92 QFNAAVQKLEEIQECHLVSGDFDYLLKTRVPDMSAYRKLLGETLLRLPGVNDTRTYVVMEEVKQTNRLVI 161
AsnC_trans_reg pfam01037
Lrp/AsnC ligand binding domain; The l-leucine-responsive regulatory protein (Lrp/AsnC) family ...
 68-142 6.58e-20

Lrp/AsnC ligand binding domain; The l-leucine-responsive regulatory protein (Lrp/AsnC) family is a family of similar bacterial transcription regulatory proteins. The family is named after two E. coli proteins involved in regulating amino acid metabolism. This entry corresponds to the usually C-terminal regulatory ligand binding domain. Structurally this domain has a dimeric alpha/beta barrel fold. This domain binds almost exclusively amino acids but also 4-hydroxyphenylpyruvate and kynurenine (Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).


Pssm-ID: 426007  Cd Length: 73  Bit Score: 77.95  E-value: 6.58e-20
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 490986541   68 VLIKTQHHSsdWYCRFVSEVTQMAEVLGFWRMAGEYDYLLRVQVADMKNYDDFYKRLVNSVPGLSDVTSSFAMEQ 142
Cdd:pfam01037   1 VEVKLEPGH--ALEEFAEALAAIPEVVECYRVTGDYDYLLKVVARDLEALERFLREKLRSLPGVARTETSIVLST 73
HTH_AsnC-type pfam13404
AsnC-type helix-turn-helix domain;
3-43 5.96e-15

AsnC-type helix-turn-helix domain;


Pssm-ID: 433180 [Multi-domain]  Cd Length: 41  Bit Score: 64.31  E-value: 5.96e-15
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 490986541    3 DKIDRKLLSLLQTDCTLSLQALADAVNLTTTPCWKRLKRLE 43
Cdd:pfam13404   1 DEIDRKILRLLQEDARISFAELAERVGLSESTVLRRIRRLE 41
HTH_24 pfam13412
Winged helix-turn-helix DNA-binding;
4-48 2.76e-13

Winged helix-turn-helix DNA-binding;


Pssm-ID: 404317 [Multi-domain]  Cd Length: 45  Bit Score: 60.14  E-value: 2.76e-13
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 490986541    4 KIDRKLLSLLQTDCTLSLQALADAVNLTTTPCWKRLKRLEDEGIL 48
Cdd:pfam13412   1 ETDRKILNLLQENPRISQRELAERLGLSPSTVNRRLKRLEEEGVI 45
BirA COG1654
Biotin operon repressor [Transcription];
1-78 4.89e-08

Biotin operon repressor [Transcription];


Pssm-ID: 441260 [Multi-domain]  Cd Length: 324  Bit Score: 50.75  E-value: 4.89e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490986541   1 MLDKIDRKLLSLLQTDCTLSLQALADAVNLTTTPCWKRLKRLEDEGI-----------LCGRVALLDAEKVGLGLTAFVL 69
Cdd:COG1654    1 MMSSTRLKLLRLLADGEFHSGEELAEELGVSRAAVWKHIKALRELGYeiesvpgkgyrLAEPPDLLDPEEIRAGLSTKRL 80


                 ....*....
gi 490986541  70 IKTQHHSSD 78
Cdd:COG1654   81 GREILYVIS 89
PRK11886 PRK11886
bifunctional biotin--[acetyl-CoA-carboxylase] ligase/biotin operon repressor BirA;
5-64 1.08e-05

bifunctional biotin--[acetyl-CoA-carboxylase] ligase/biotin operon repressor BirA;


Pssm-ID: 237010 [Multi-domain]  Cd Length: 319  Bit Score: 43.62  E-value: 1.08e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 490986541   5 IDRKLLSLLQTDCTLSLQALADAVNLTTTPCWKRLKRLEDEGILCGRVA-----------LLDAEKVGLGL 64
Cdd:PRK11886   5 VMLQLLSLLADGDFHSGEQLGEELGISRAAIWKHIQTLEEWGLDIFSVKgkgyrlaepldLLDPERISSQL 75
HTH_ARSR cd00090
Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric ...
 1-51 1.29e-04

Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.


Pssm-ID: 238042 [Multi-domain]  Cd Length: 78  Bit Score: 38.43  E-value: 1.29e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|.
gi 490986541   1 MLDKIDRKLLSLLQTDCtLSLQALADAVNLTTTPCWKRLKRLEDEGILCGR 51
Cdd:cd00090    4 LSDPTRLRILRLLLEGP-LTVSELAERLGLSQSTVSRHLKKLEEAGLVESR 53
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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