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Conserved domains on  [gi|490795674|ref|WP_004657820|]
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MULTISPECIES: MarR family winged helix-turn-helix transcriptional regulator [Pseudomonas]

Protein Classification

MarR family winged helix-turn-helix transcriptional regulator( domain architecture ID 11448790)

MarR family winged helix-turn-helix (wHTH) transcriptional regulator similar to Bacillus thuringiensis DNA-binding transcriptional repressor TubR, a DNA-binding protein that is part of the type III plasmid partition system used to ensure correct segregation of the pBtoxis plasmid

Gene Ontology:  GO:0006355|GO:0003700
PubMed:  10498949|28670937
SCOP:  4000246

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MarR COG1846
DNA-binding transcriptional regulator, MarR family [Transcription];
2-132 3.18e-21

DNA-binding transcriptional regulator, MarR family [Transcription];


:

Pssm-ID: 441451 [Multi-domain]  Cd Length: 142  Bit Score: 83.48  E-value: 3.18e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490795674   2 SSAEPDTWFRFVRAHRCLIREIERRLAAAELPPyAWYDALWGVESGPQgmRRMHELADVMAIERYNLTRLIDRLESEGLV 81
Cdd:COG1846    6 DPAEERLGLLLRRLARALRRALDRALAELGLTP-AQFRVLAALAEAGG--LTQSELAERLGLTKSTVSRLLDRLEEKGLV 82

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 490795674  82 ERHRSDSDGRGAVAAITDKGRTLRKQMWQIYETAVDELFlAQFDAPQRRVF 132
Cdd:COG1846   83 EREPDPEDRRAVLVRLTEKGRALLEEARPALEALLAELL-AGLSEEELEAL 132
 
Name Accession Description Interval E-value
MarR COG1846
DNA-binding transcriptional regulator, MarR family [Transcription];
2-132 3.18e-21

DNA-binding transcriptional regulator, MarR family [Transcription];


Pssm-ID: 441451 [Multi-domain]  Cd Length: 142  Bit Score: 83.48  E-value: 3.18e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490795674   2 SSAEPDTWFRFVRAHRCLIREIERRLAAAELPPyAWYDALWGVESGPQgmRRMHELADVMAIERYNLTRLIDRLESEGLV 81
Cdd:COG1846    6 DPAEERLGLLLRRLARALRRALDRALAELGLTP-AQFRVLAALAEAGG--LTQSELAERLGLTKSTVSRLLDRLEEKGLV 82

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 490795674  82 ERHRSDSDGRGAVAAITDKGRTLRKQMWQIYETAVDELFlAQFDAPQRRVF 132
Cdd:COG1846   83 EREPDPEDRRAVLVRLTEKGRALLEEARPALEALLAELL-AGLSEEELEAL 132
HTH_MARR smart00347
helix_turn_helix multiple antibiotic resistance protein;
54-129 3.84e-13

helix_turn_helix multiple antibiotic resistance protein;


Pssm-ID: 197670 [Multi-domain]  Cd Length: 101  Bit Score: 61.46  E-value: 3.84e-13
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 490795674    54 MHELADVMAIERYNLTRLIDRLESEGLVERHRSDSDGRGAVAAITDKGRTLRKQMWQIYETAVDELFlAQFDAPQR 129
Cdd:smart00347  27 VSELAKRLGVSPSTVTRVLDRLEKKGLVRREPSPEDRRSVLVSLTEEGRELIEQLLEARSETLAELL-AGLTAEEQ 101
MarR_2 pfam12802
MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a ...
 34-92 7.14e-08

MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a non-specific resistance system. The expression of the mar operon is controlled by a repressor, MarR. A large number of compounds induce transcription of the mar operon. This is thought to be due to the compound binding to MarR, and the resulting complex stops MarR binding to the DNA. With the MarR repression lost, transcription of the operon proceeds. The structure of MarR is known and shows MarR as a dimer with each subunit containing a winged-helix DNA binding motif.


Pssm-ID: 432797 [Multi-domain]  Cd Length: 60  Bit Score: 46.43  E-value: 7.14e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 490795674   34 PYAWYDALWGVESGPQgmRRMHELADVMAIERYNLTRLIDRLESEGLVERHRSDSDGRG 92
Cdd:pfam12802   4 TPAQFRVLLALARNPG--LTVAELARRLGISKQTVSRLVKRLEAKGLVEREPSPADRRA 60
PRK03573 PRK03573
transcriptional regulator SlyA; Provisional
 11-120 1.44e-07

transcriptional regulator SlyA; Provisional


Pssm-ID: 179596  Cd Length: 144  Bit Score: 47.69  E-value: 1.44e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490795674  11 RFVRAHRCLIREierRLAAAELPPYAWYdALWGVESGPQGMRRMhELADVMAIERYNLTRLIDRLESEGLVERHRSDSDG 90
Cdd:PRK03573  11 RLVRIWRALIDH---RLKPLELTQTHWV-TLHNIHQLPPEQSQI-QLAKAIGIEQPSLVRTLDQLEEKGLISRQTCASDR 85

                         90       100       110
                 ....*....|....*....|....*....|
gi 490795674  91 RGAVAAITDKGRTLRKQMWQIYETAVDELF 120
Cdd:PRK03573  86 RAKRIKLTEKAEPLISEVEAVINKTRAEIL 115
 
Name Accession Description Interval E-value
MarR COG1846
DNA-binding transcriptional regulator, MarR family [Transcription];
2-132 3.18e-21

DNA-binding transcriptional regulator, MarR family [Transcription];


Pssm-ID: 441451 [Multi-domain]  Cd Length: 142  Bit Score: 83.48  E-value: 3.18e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490795674   2 SSAEPDTWFRFVRAHRCLIREIERRLAAAELPPyAWYDALWGVESGPQgmRRMHELADVMAIERYNLTRLIDRLESEGLV 81
Cdd:COG1846    6 DPAEERLGLLLRRLARALRRALDRALAELGLTP-AQFRVLAALAEAGG--LTQSELAERLGLTKSTVSRLLDRLEEKGLV 82

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 490795674  82 ERHRSDSDGRGAVAAITDKGRTLRKQMWQIYETAVDELFlAQFDAPQRRVF 132
Cdd:COG1846   83 EREPDPEDRRAVLVRLTEKGRALLEEARPALEALLAELL-AGLSEEELEAL 132
HTH_MARR smart00347
helix_turn_helix multiple antibiotic resistance protein;
54-129 3.84e-13

helix_turn_helix multiple antibiotic resistance protein;


Pssm-ID: 197670 [Multi-domain]  Cd Length: 101  Bit Score: 61.46  E-value: 3.84e-13
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 490795674    54 MHELADVMAIERYNLTRLIDRLESEGLVERHRSDSDGRGAVAAITDKGRTLRKQMWQIYETAVDELFlAQFDAPQR 129
Cdd:smart00347  27 VSELAKRLGVSPSTVTRVLDRLEKKGLVRREPSPEDRRSVLVSLTEEGRELIEQLLEARSETLAELL-AGLTAEEQ 101
MarR_2 pfam12802
MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a ...
 34-92 7.14e-08

MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a non-specific resistance system. The expression of the mar operon is controlled by a repressor, MarR. A large number of compounds induce transcription of the mar operon. This is thought to be due to the compound binding to MarR, and the resulting complex stops MarR binding to the DNA. With the MarR repression lost, transcription of the operon proceeds. The structure of MarR is known and shows MarR as a dimer with each subunit containing a winged-helix DNA binding motif.


Pssm-ID: 432797 [Multi-domain]  Cd Length: 60  Bit Score: 46.43  E-value: 7.14e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 490795674   34 PYAWYDALWGVESGPQgmRRMHELADVMAIERYNLTRLIDRLESEGLVERHRSDSDGRG 92
Cdd:pfam12802   4 TPAQFRVLLALARNPG--LTVAELARRLGISKQTVSRLVKRLEAKGLVEREPSPADRRA 60
PRK03573 PRK03573
transcriptional regulator SlyA; Provisional
 11-120 1.44e-07

transcriptional regulator SlyA; Provisional


Pssm-ID: 179596  Cd Length: 144  Bit Score: 47.69  E-value: 1.44e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490795674  11 RFVRAHRCLIREierRLAAAELPPYAWYdALWGVESGPQGMRRMhELADVMAIERYNLTRLIDRLESEGLVERHRSDSDG 90
Cdd:PRK03573  11 RLVRIWRALIDH---RLKPLELTQTHWV-TLHNIHQLPPEQSQI-QLAKAIGIEQPSLVRTLDQLEEKGLISRQTCASDR 85

                         90       100       110
                 ....*....|....*....|....*....|
gi 490795674  91 RGAVAAITDKGRTLRKQMWQIYETAVDELF 120
Cdd:PRK03573  86 RAKRIKLTEKAEPLISEVEAVINKTRAEIL 115
MarR pfam01047
MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a ...
 45-91 6.94e-07

MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a non-specific resistance system. The expression of the mar operon is controlled by a repressor, MarR. A large number of compounds induce transcription of the mar operon. This is thought to be due to the compound binding to MarR, and the resulting complex stops MarR binding to the DNA. With the MarR repression lost, transcription of the operon proceeds. The structure of MarR is known and shows MarR as a dimer with each subunit containing a winged-helix DNA binding motif.


Pssm-ID: 426012 [Multi-domain]  Cd Length: 59  Bit Score: 44.08  E-value: 6.94e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 490795674   45 ESGPQgmrRMHELADVMAIERYNLTRLIDRLESEGLVERHRSDSDGR 91
Cdd:pfam01047  14 EHGPL---TVSELAEKLGVSKSTVTRVLDRLEKKGLIERSRSPEDRR 57
PRK11512 PRK11512
multiple antibiotic resistance transcriptional regulator MarR;
56-111 2.04e-05

multiple antibiotic resistance transcriptional regulator MarR;


Pssm-ID: 183170  Cd Length: 144  Bit Score: 41.81  E-value: 2.04e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 490795674  56 ELADVMAIERYNLTRLIDRLESEGLVERHRSDSDGRGAVAAITDKGRTLRKQMWQI 111
Cdd:PRK11512  59 ELKKVLSVDLGALTRMLDRLVCKGWVERLPNPNDKRGVLVKLTTSGAAICEQCHQL 114
PRK10870 PRK10870
transcriptional repressor MprA; Provisional
 56-101 8.35e-04

transcriptional repressor MprA; Provisional


Pssm-ID: 182795  Cd Length: 176  Bit Score: 37.81  E-value: 8.35e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*.
gi 490795674  56 ELADVMAIERYNLTRLIDRLESEGLVERHRSDSDGRGAVAAITDKG 101
Cdd:PRK10870  76 ELSCALGSSRTNATRIADELEKRGWIERRESDNDRRCLHLQLTEKG 121
COG1672 COG1672
Predicted ATPase, archaeal AAA+ ATPase superfamily [General function prediction only];
50-99 5.20e-03

Predicted ATPase, archaeal AAA+ ATPase superfamily [General function prediction only];


Pssm-ID: 441278 [Multi-domain]  Cd Length: 324  Bit Score: 36.05  E-value: 5.20e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|
gi 490795674  50 GMRRMHELADVMAIERYNLTRLIDRLESEGLVERHRSDSDGRGAVAAITD 99
Cdd:COG1672  257 GATRLSEIASALGISSSSLSRYLKNLIDLGIIEKEVPVEKSKKGRYRIAD 306
COG3355 COG3355
Predicted transcriptional regulator [Transcription];
56-92 7.78e-03

Predicted transcriptional regulator [Transcription];


Pssm-ID: 442583 [Multi-domain]  Cd Length: 131  Bit Score: 34.55  E-value: 7.78e-03
                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 490795674  56 ELADVMAIERYNLTRLIDRLESEGLVERHRSDSDGRG 92
Cdd:COG3355   47 ELAEALDRSRSTVYRSLQKLLEAGLVEREKRNLEGGG 83
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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