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Conserved domains on  [gi|490533394|ref|WP_004398566|]
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MULTISPECIES: DUF3199 family protein [Bacillus]

Protein Classification

head-tail connector protein( domain architecture ID 11189273)

phage gp6-like head-tail connector protein is critical in the assembly of the connector, a specialized phage structure that serves as an interface for head and tail attachment, as well as a point at which DNA exits the head during infection by the bacteriophage

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
DUF3199 pfam11436
Protein of unknown function (DUF3199); Some members in this family of proteins with unknown ...
 4-129 5.82e-70

Protein of unknown function (DUF3199); Some members in this family of proteins with unknown function are annotated as YqbG however this cannot be confirmed. Currently the proteins has no known function.


:

Pssm-ID: 402857  Cd Length: 123  Bit Score: 205.82  E-value: 5.82e-70
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490533394    4 ITPDELKSYSVFESVKTRPDELLKQDILEATADIILKVGHDFSDAEYIPLPETVRLALLKLSQFYALINGDESIIKGYTT 83
Cdd:pfam11436   1 ITPDDVISYSVFERVKNRPPELLEQDIIEAEAEIKLIVGHDFSDELYDPLPEKVRLALLKLAQYFALINSDESITKGYQS 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 490533394   84 EKIGDYSYTLGDGSSLQKPDVYALIKDYVKPAdPDLEgiEAKVRMR 129
Cdd:pfam11436  81 EKIGDYSYTLANGQTLQKPDVYALLEDYIKPK-LTTE--STRLKVR 123
 
Name Accession Description Interval E-value
DUF3199 pfam11436
Protein of unknown function (DUF3199); Some members in this family of proteins with unknown ...
 4-129 5.82e-70

Protein of unknown function (DUF3199); Some members in this family of proteins with unknown function are annotated as YqbG however this cannot be confirmed. Currently the proteins has no known function.


Pssm-ID: 402857  Cd Length: 123  Bit Score: 205.82  E-value: 5.82e-70
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490533394    4 ITPDELKSYSVFESVKTRPDELLKQDILEATADIILKVGHDFSDAEYIPLPETVRLALLKLSQFYALINGDESIIKGYTT 83
Cdd:pfam11436   1 ITPDDVISYSVFERVKNRPPELLEQDIIEAEAEIKLIVGHDFSDELYDPLPEKVRLALLKLAQYFALINSDESITKGYQS 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 490533394   84 EKIGDYSYTLGDGSSLQKPDVYALIKDYVKPAdPDLEgiEAKVRMR 129
Cdd:pfam11436  81 EKIGDYSYTLANGQTLQKPDVYALLEDYIKPK-LTTE--STRLKVR 123
Yqbg cd08053
Putative Head-Tail Connector Protein Yqbg from Bacillus subtilis and similar proteins; The ...
 4-114 2.11e-37

Putative Head-Tail Connector Protein Yqbg from Bacillus subtilis and similar proteins; The uncharacterized Bacillus subtilis Yqbg protein, whose gene is part of the unusual genetic element called skin, shows a similar structure to the connector proteins gp6 and gp15 from bacteriophage HK97 and SPP1, respectively. gp6 and gp15 are critical in the assembly of the connector, a specialized structure that serves as an interface for head and tail attachment, as well as a point at which DNA exits the head during infection by the bacteriophage. They form dodecameric ring structures that comprise the middle ring of the connector, located between the portal protein (attached to the head) and the gp7/gp16 ring (attached to the tail). The Yqbg gene is surrounded with genes similar to genes in the Bacillus subtilis prophage-like element PBSX, which encode for proteins comprising contractile-tailed phage-like particles that are produced upon mitomycin C treatment. Yqbg likely acts as a head-tail connector protein, similar to gp6 and gp15, of the PBSX-like prophage encoded in the skin element.


Pssm-ID: 153445  Cd Length: 121  Bit Score: 123.24  E-value: 2.11e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490533394   4 ITPDELKSYSVFESVKTRPDELLKQDILEATADIILKVGHDFSDAEYIPLPETVRLALLKLSQFYALINGDESIIKGYTT 83
Cdd:cd08053    1 MTYADYEFYTEEYYGKERPEELLKKDILRASAKIDKITFGRFDDLGYPEIPEEVKLAVCALAEYIALIDGDESSGGGVTS 80

                         90       100       110
                 ....*....|....*....|....*....|...
gi 490533394  84 EKIGDYSYTLGDGSS--LQKPDVYALIKDYVKP 114
Cdd:cd08053   81 ESIGDYSVSYSSGTSgsLAKKDVYNLLLDYLAP 113
 
Name Accession Description Interval E-value
DUF3199 pfam11436
Protein of unknown function (DUF3199); Some members in this family of proteins with unknown ...
 4-129 5.82e-70

Protein of unknown function (DUF3199); Some members in this family of proteins with unknown function are annotated as YqbG however this cannot be confirmed. Currently the proteins has no known function.


Pssm-ID: 402857  Cd Length: 123  Bit Score: 205.82  E-value: 5.82e-70
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490533394    4 ITPDELKSYSVFESVKTRPDELLKQDILEATADIILKVGHDFSDAEYIPLPETVRLALLKLSQFYALINGDESIIKGYTT 83
Cdd:pfam11436   1 ITPDDVISYSVFERVKNRPPELLEQDIIEAEAEIKLIVGHDFSDELYDPLPEKVRLALLKLAQYFALINSDESITKGYQS 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 490533394   84 EKIGDYSYTLGDGSSLQKPDVYALIKDYVKPAdPDLEgiEAKVRMR 129
Cdd:pfam11436  81 EKIGDYSYTLANGQTLQKPDVYALLEDYIKPK-LTTE--STRLKVR 123
Yqbg cd08053
Putative Head-Tail Connector Protein Yqbg from Bacillus subtilis and similar proteins; The ...
 4-114 2.11e-37

Putative Head-Tail Connector Protein Yqbg from Bacillus subtilis and similar proteins; The uncharacterized Bacillus subtilis Yqbg protein, whose gene is part of the unusual genetic element called skin, shows a similar structure to the connector proteins gp6 and gp15 from bacteriophage HK97 and SPP1, respectively. gp6 and gp15 are critical in the assembly of the connector, a specialized structure that serves as an interface for head and tail attachment, as well as a point at which DNA exits the head during infection by the bacteriophage. They form dodecameric ring structures that comprise the middle ring of the connector, located between the portal protein (attached to the head) and the gp7/gp16 ring (attached to the tail). The Yqbg gene is surrounded with genes similar to genes in the Bacillus subtilis prophage-like element PBSX, which encode for proteins comprising contractile-tailed phage-like particles that are produced upon mitomycin C treatment. Yqbg likely acts as a head-tail connector protein, similar to gp6 and gp15, of the PBSX-like prophage encoded in the skin element.


Pssm-ID: 153445  Cd Length: 121  Bit Score: 123.24  E-value: 2.11e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490533394   4 ITPDELKSYSVFESVKTRPDELLKQDILEATADIILKVGHDFSDAEYIPLPETVRLALLKLSQFYALINGDESIIKGYTT 83
Cdd:cd08053    1 MTYADYEFYTEEYYGKERPEELLKKDILRASAKIDKITFGRFDDLGYPEIPEEVKLAVCALAEYIALIDGDESSGGGVTS 80

                         90       100       110
                 ....*....|....*....|....*....|...
gi 490533394  84 EKIGDYSYTLGDGSS--LQKPDVYALIKDYVKP 114
Cdd:cd08053   81 ESIGDYSVSYSSGTSgsLAKKDVYNLLLDYLAP 113
gp6_gp15_like cd08051
Head-Tail Connector Proteins gp6 and gp15, and similar proteins; Members of this family ...
 7-112 1.18e-33

Head-Tail Connector Proteins gp6 and gp15, and similar proteins; Members of this family include the proteins gp6 and gp15 from bacteriophage HK97 and SPP1, respectively. They are critical in the assembly of the connector, a specialized structure that serves as an interface for head and tail attachment, as well as a point at which DNA exits the head during infection by the bacteriophage. They form dodecameric ring structures that comprise the middle ring of the connector, located between the portal protein (attached to the head) and the gp7/gp16 ring (attached to the tail). They are components of the mature phage and the absence or mutation of HK97 gp6 or SPP1 gp15, respectively, result in defective head-tail joining and the absence of mature phage particles. The genome maps of HK97 and SPP1 show that genes encoding gp6 and gp15 are in the same relative position on the genome, located adjacent to the major capsid protein (MCP) gene and in between head and tail genes. Also included in this family is the uncharacterized Bacillus subtilis Yqbg protein, whose gene is part of the unusual genetic element called skin. The Yqbg gene is surrounded with genes similar to genes in the Bacillus subtilis prophage-like element PBSX, which encode for proteins comprising contractile-tailed phage-like particles that are produced upon mitomycin C treatment. Yqbg likely acts as a head-tail connector protein, similar to gp6 and gp15, of the PBSX-like prophage encoded in the skin element.


Pssm-ID: 153444  Cd Length: 94  Bit Score: 112.81  E-value: 1.18e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490533394   7 DELKSYSVFESVktRPDELLKQDILEATADIILKVGHDFSDAEYIPLPETVRLALLKLSQFYALINGDESIIKGytteki 86
Cdd:cd08051    1 SLFKQQIEFEED--DRDELLTLYAQAAFDYC*RWCDEPFWDAVAADIPAAVKGAVLKVFQFYFEHRGAQSIIKD------ 72

                         90       100
                 ....*....|....*....|....*.
gi 490533394  87 gdysYTLGDGSSLQKPDVYALIKDYV 112
Cdd:cd08051   73 ----TTLGEVQLYENAAAER**FIYR 94
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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