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Conserved domains on  [gi|490432161|ref|WP_004304269|]
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MULTISPECIES: RteC domain-containing protein [Bacteria]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
RteC super family cl09614
RteC protein; Human colonic Bacteroides species harbor a family of large conjugative ...
 113-194 8.08e-27

RteC protein; Human colonic Bacteroides species harbor a family of large conjugative transposons, called tetracycline resistance (Tcr) elements. Activities of these elements are enhanced by pregrowth of bacteria in medium containing tetracycline, indicating that at least some Tcr element genes are regulated by tetracycline. An insertional disruption in the rteC gene abolished self-transfer of the Tcr element to Bacteroides recipients, indicating that the gene was essential for self-transfer.


The actual alignment was detected with superfamily member pfam09357:

Pssm-ID: 430555  Cd Length: 218  Bit Score: 101.49  E-value: 8.08e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490432161  113 LQWTGNAIDLVELIYGIDVMGCINNGNMPLKQLAPLLYKIFGVDSKDCYRFYTDIKRRKNeSRTYFIDRMQEKLNERMLR 192
Cdd:pfam09357 138 LKWTGSKTALVELIYALHSSGVINNGNADIKDIARVFETLFNVDLGDYYRTFLEIKNRKK-SRTKFLDKLKEALLKRMDE 216


                  ..
gi 490432161  193 DE 194
Cdd:pfam09357 217 DD 218
 
Name Accession Description Interval E-value
RteC pfam09357
RteC protein; Human colonic Bacteroides species harbor a family of large conjugative ...
 113-194 8.08e-27

RteC protein; Human colonic Bacteroides species harbor a family of large conjugative transposons, called tetracycline resistance (Tcr) elements. Activities of these elements are enhanced by pregrowth of bacteria in medium containing tetracycline, indicating that at least some Tcr element genes are regulated by tetracycline. An insertional disruption in the rteC gene abolished self-transfer of the Tcr element to Bacteroides recipients, indicating that the gene was essential for self-transfer.


Pssm-ID: 430555  Cd Length: 218  Bit Score: 101.49  E-value: 8.08e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490432161  113 LQWTGNAIDLVELIYGIDVMGCINNGNMPLKQLAPLLYKIFGVDSKDCYRFYTDIKRRKNeSRTYFIDRMQEKLNERMLR 192
Cdd:pfam09357 138 LKWTGSKTALVELIYALHSSGVINNGNADIKDIARVFETLFNVDLGDYYRTFLEIKNRKK-SRTKFLDKLKEALLKRMDE 216


                  ..
gi 490432161  193 DE 194
Cdd:pfam09357 217 DD 218
 
Name Accession Description Interval E-value
RteC pfam09357
RteC protein; Human colonic Bacteroides species harbor a family of large conjugative ...
 113-194 8.08e-27

RteC protein; Human colonic Bacteroides species harbor a family of large conjugative transposons, called tetracycline resistance (Tcr) elements. Activities of these elements are enhanced by pregrowth of bacteria in medium containing tetracycline, indicating that at least some Tcr element genes are regulated by tetracycline. An insertional disruption in the rteC gene abolished self-transfer of the Tcr element to Bacteroides recipients, indicating that the gene was essential for self-transfer.


Pssm-ID: 430555  Cd Length: 218  Bit Score: 101.49  E-value: 8.08e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490432161  113 LQWTGNAIDLVELIYGIDVMGCINNGNMPLKQLAPLLYKIFGVDSKDCYRFYTDIKRRKNeSRTYFIDRMQEKLNERMLR 192
Cdd:pfam09357 138 LKWTGSKTALVELIYALHSSGVINNGNADIKDIARVFETLFNVDLGDYYRTFLEIKNRKK-SRTKFLDKLKEALLKRMDE 216


                  ..
gi 490432161  193 DE 194
Cdd:pfam09357 217 DD 218
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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