|
Name |
Accession |
Description |
Interval |
E-value |
| AKR_AKR13C1_2 |
cd19078 |
AKR13C family of aldo-keto reductase (AKR); The AKR13C family includes Helicobacter pyroli ... |
74-372 |
0e+00 |
|
AKR13C family of aldo-keto reductase (AKR); The AKR13C family includes Helicobacter pyroli aldehyde reductase (AKR13C1) and Thermotoga maritima aldo-keto reductase (AKR13C2). Aldehyde reductase (EC 1.1.1.21), also called aldose reductase, is a cytosolic NADPH-dependent oxidoreductase that catalyzes the reduction of a variety of aldehydes and carbonyls, including monosaccharides.
Pssm-ID: 381304 [Multi-domain] Cd Length: 301 Bit Score: 507.16 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490304600 74 LEVSSMGLGCLPMVGYYGGgPRDRKAMVSLIRAAFEQGITFFDTAEVYGPHLSEEFVGEALAPVRDRVVIATKFGFGVEE 153
Cdd:cd19078 2 LEVSAIGLGCMGMSHGYGP-PPDKEEMIELIRKAVELGITFFDTAEVYGPYTNEELVGEALKPFRDQVVIATKFGFKIDG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490304600 154 GKPTS--LNSHPDHIRRAVEGSLKRLKTDHIDLLYQHRPDPNVPIEDVAETVKALILEGKVKHWGLSEASARTIRRAHAV 231
Cdd:cd19078 81 GKPGPlgLDSRPEHIRKAVEGSLKRLQTDYIDLYYQHRVDPNVPIEEVAGTMKELIKEGKIRHWGLSEAGVETIRRAHAV 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490304600 232 LPVTAVQSEYAMWWREPETRIFPTLEELGIGFVPYCPTARSFLAGAVNPSQRFDSTDRRHNLPRFQPDALAKNMVLLEFA 311
Cdd:cd19078 161 CPVTAVQSEYSMMWREPEKEVLPTLEELGIGFVPFSPLGKGFLTGKIDENTKFDEGDDRASLPRFTPEALEANQALVDLL 240
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 490304600 312 QSWARRKNTTPVQFALAWVMAQRPWIVPIPGTTQYPHLIENSGAPQVRLTDRELREIDAAL 372
Cdd:cd19078 241 KEFAEEKGATPAQIALAWLLAKKPWIVPIPGTTKLSRLEENIGAADIELTPEELREIEDAL 301
|
|
| AKR_AKR13A_13D |
cd19076 |
AKR13A and AKR13D families of aldo-keto reductase (AKR); Schizosaccharomyces pombe aldo-keto ... |
68-368 |
1.37e-146 |
|
AKR13A and AKR13D families of aldo-keto reductase (AKR); Schizosaccharomyces pombe aldo-keto reductase YakC is a founding member of aldo-keto reductase family 13 member A1 (AKR13A1). It catalyzes the reversible reduction of ketones to the respective alcohols using NADP(+) as a hydride donor. Rauvolfia serpentina PR is a founding member of aldo-keto reductase family 13 member D1 (AKR13D1). It catalyzes the NADPH-dependent reduction of the aldehyde perakine to yield the alcohol raucaffrinoline in the biosynthetic pathway of ajmaline in Rauvolfia, a key step in indole alkaloid biosynthesis. This family also includes Arabidopsis thaliana aldo-keto reductases, ALKR1-6.
Pssm-ID: 381302 [Multi-domain] Cd Length: 303 Bit Score: 417.39 E-value: 1.37e-146
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490304600 68 TRKLGS--LEVSSMGLGCLPMVGYYGggPRDRKAMVSLIRAAFEQGITFFDTAEVYGPHLSEEFVGEALAPVRDRVVIAT 145
Cdd:cd19076 2 TRKLGTqgLEVSALGLGCMGMSAFYG--PADEEESIATLHRALELGVTFLDTADMYGPGTNEELLGKALKDRRDEVVIAT 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490304600 146 KFGFGVEEG-KPTSLNSHPDHIRRAVEGSLKRLKTDHIDLLYQHRPDPNVPIEDVAETVKALILEGKVKHWGLSEASART 224
Cdd:cd19076 80 KFGIVRDPGsGFRGVDGRPEYVRAACEASLKRLGTDVIDLYYQHRVDPNVPIEETVGAMAELVEEGKVRYIGLSEASADT 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490304600 225 IRRAHAVLPVTAVQSEYAMWWREPETRIFPTLEELGIGFVPYCPTARSFLAGAVNPSQRFDSTDRRHNLPRFQPDALAKN 304
Cdd:cd19076 160 IRRAHAVHPITAVQSEYSLWTRDIEDEVLPTCRELGIGFVAYSPLGRGFLTGAIKSPEDLPEDDFRRNNPRFQGENFDKN 239
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 490304600 305 MVLLEFAQSWARRKNTTPVQFALAWVMAQRPWIVPIPGTTQYPHLIENSGAPQVRLTDRELREI 368
Cdd:cd19076 240 LKLVEKLEAIAAEKGCTPAQLALAWVLAQGDDIVPIPGTKRIKYLEENVGALDVVLTPEELAEI 303
|
|
| PdxI |
COG0667 |
Pyridoxal reductase PdxI or related oxidoreductase, aldo/keto reductase family [Coenzyme ... |
67-376 |
3.12e-121 |
|
Pyridoxal reductase PdxI or related oxidoreductase, aldo/keto reductase family [Coenzyme transport and metabolism, General function prediction only];
Pssm-ID: 440431 [Multi-domain] Cd Length: 316 Bit Score: 353.71 E-value: 3.12e-121
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490304600 67 TTRKLGS--LEVSSMGLGCLPMVGYYGggPRDRKAMVSLIRAAFEQGITFFDTAEVYGPHLSEEFVGEALAPV-RDRVVI 143
Cdd:COG0667 2 EYRRLGRsgLKVSRLGLGTMTFGGPWG--GVDEAEAIAILDAALDAGINFFDTADVYGPGRSEELLGEALKGRpRDDVVI 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490304600 144 ATKFGFGVEEGkPTSLNSHPDHIRRAVEGSLKRLKTDHIDLLYQHRPDPNVPIEDVAETVKALILEGKVKHWGLSEASAR 223
Cdd:COG0667 80 ATKVGRRMGPG-PNGRGLSREHIRRAVEASLRRLGTDYIDLYQLHRPDPDTPIEETLGALDELVREGKIRYIGVSNYSAE 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490304600 224 TIRRAHAVL----PVTAVQSEYAMWWREPETRIFPTLEELGIGFVPYCPTARSFLAGAVNPSQRFDSTDRRhNLPRFQPD 299
Cdd:COG0667 159 QLRRALAIAeglpPIVAVQNEYSLLDRSAEEELLPAARELGVGVLAYSPLAGGLLTGKYRRGATFPEGDRA-ATNFVQGY 237
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 490304600 300 ALAKNMVLLEFAQSWARRKNTTPVQFALAWVMAQRPWIVPIPGTTQYPHLIENSGAPQVRLTDRELREIDAALAKIP 376
Cdd:COG0667 238 LTERNLALVDALRAIAAEHGVTPAQLALAWLLAQPGVTSVIPGARSPEQLEENLAAADLELSAEDLAALDAALAAVP 314
|
|
| AKR_AKR13D1 |
cd19145 |
AKR13D family of aldo-keto reductase (AKR); Rauvolfia serpentina PR is a founding member of ... |
68-368 |
1.95e-116 |
|
AKR13D family of aldo-keto reductase (AKR); Rauvolfia serpentina PR is a founding member of aldo-keto reductase family 13 member D1 (AKR13D1). It catalyzes the NADPH-dependent reduction of the aldehyde perakine to yield the alcohol raucaffrinoline in the biosynthetic pathway of ajmaline in Rauvolfia, a key step in indole alkaloid biosynthesis. This family also includes Arabidopsis thaliana aldo-keto reductases, ALKR1-6.
Pssm-ID: 381371 [Multi-domain] Cd Length: 304 Bit Score: 340.95 E-value: 1.95e-116
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490304600 68 TRKLGS--LEVSSMGLGCLPMVGYYGGgPRDRKAMVSLIRAAFEQGITFFDTAEVYGPHLSEEFVGEAL-APVRDRVVIA 144
Cdd:cd19145 2 RVKLGSqgLEVSAQGLGCMGLSGDYGA-PKPEEEGIALIHHAFNSGVTFLDTSDIYGPNTNEVLLGKALkDGPREKVQLA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490304600 145 TKFGFGVEEGKPTSLNSHPDHIRRAVEGSLKRLKTDHIDLLYQHRPDPNVPIEDVAETVKALILEGKVKHWGLSEASART 224
Cdd:cd19145 81 TKFGIHEIGGSGVEVRGDPAYVRAACEASLKRLDVDYIDLYYQHRIDTTVPIEITMGELKKLVEEGKIKYIGLSEASADT 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490304600 225 IRRAHAVLPVTAVQSEYAMWWREPETRIFPTLEELGIGFVPYCPTARSFLAGAVNPSQRFDSTDRRHNLPRFQPDALAKN 304
Cdd:cd19145 161 IRRAHAVHPITAVQLEWSLWTRDIEEEIIPTCRELGIGIVPYSPLGRGFFAGKAKLEELLENSDVRKSHPRFQGENLEKN 240
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 490304600 305 MVLLEFAQSWARRKNTTPVQFALAWVMAQRPWIVPIPGTTQYPHLIENSGAPQVRLTDRELREI 368
Cdd:cd19145 241 KVLYERVEALAKKKGCTPAQLALAWVLHQGEDVVPIPGTTKIKNLNQNIGALSVKLTKEDLKEI 304
|
|
| AKR_AKR11B1-like |
cd19084 |
AKR11B1/AKR11B2 subfamily of aldo-keto reductase (AKR); Bacillus subtilis YhdN, also called ... |
73-369 |
1.16e-106 |
|
AKR11B1/AKR11B2 subfamily of aldo-keto reductase (AKR); Bacillus subtilis YhdN, also called general stress protein 69 (GSP69), is a founding member of aldo-keto reductase family 11 member B1 (AKR11B1). It acts as an aldo-keto reductase (AKR) that catalyzes the reversible reduction of ketones to the respective alcohols using NAD(P)H as a hydride donor. Escherichia coli YdjG is a founding member of aldo-keto reductase family 11 member B2 (AKR11B2). It catalyzes the NADH-dependent reduction of methylglyoxal (2-oxopropanal) in vitro. It may play some role in intestinal colonization.
Pssm-ID: 381310 [Multi-domain] Cd Length: 296 Bit Score: 315.62 E-value: 1.16e-106
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490304600 73 SLEVSSMGLGCLPMVGYYGGGPRDRKAmVSLIRAAFEQGITFFDTAEVYGPHLSEEFVGEALAPVRDRVVIATKFGFGVE 152
Cdd:cd19084 1 DLKVSRIGLGTWAIGGTWWGEVDDQES-IEAIKAAIDLGINFFDTAPVYGFGHSEEILGKALKGRRDDVVIATKCGLRWD 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490304600 153 EGKPTSLNSHPDHIRRAVEGSLKRLKTDHIDlLYQ-HRPDPNVPIEDVAETVKALILEGKVKHWGLSEASARTIRRAHAV 231
Cdd:cd19084 80 GGKGVTKDLSPESIRKEVEQSLRRLQTDYID-LYQiHWPDPNTPIEETAEALEKLKKEGKIRYIGVSNFSVEQLEEARKY 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490304600 232 LPVTAVQSEYAMWWREPETRIFPTLEELGIGFVPYCPTARSFLAGAVNPSQRFDSTDRRHNLPRFQPDALAKNMVLLEFA 311
Cdd:cd19084 159 GPIVSLQPPYSMLEREIEEELLPYCRENGIGVLPYGPLAQGLLTGKYKKEPTFPPDDRRSRFPFFRGENFEKNLEIVDKL 238
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*...
gi 490304600 312 QSWARRKNTTPVQFALAWVMAQRPWIVPIPGTTQYPHLIENSGAPQVRLTDRELREID 369
Cdd:cd19084 239 KEIAEKYGKSLAQLAIAWTLAQPGVTSAIVGAKNPEQLEENAGALDWELTEEELKEID 296
|
|
| AKR_AKR13A1 |
cd19144 |
AKR13A family of aldo-keto reductase (AKR); Schizosaccharomyces pombe aldo-keto reductase YakC ... |
66-381 |
2.83e-94 |
|
AKR13A family of aldo-keto reductase (AKR); Schizosaccharomyces pombe aldo-keto reductase YakC is a founding member of aldo-keto reductase family 13 member A1 (AKR13A1). It catalyzes the reversible reduction of ketones to the respective alcohols using NADP(+) as a hydride donor.
Pssm-ID: 381370 [Multi-domain] Cd Length: 323 Bit Score: 285.11 E-value: 2.83e-94
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490304600 66 LTTRKLGSL--EVSSMGLGCLPMVGYYGGGPRDRKAMvSLIRAAFEQGITFFDTAEVYGPHlsEEFVGE--ALAP-VRDR 140
Cdd:cd19144 1 IPTRTLGRNgpSVPALGFGAMGLSAFYGPPKPDEERF-AVLDAAFELGCTFWDTADIYGDS--EELIGRwfKQNPgKREK 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490304600 141 VVIATKFGF-GVEEGKPTSLNSHPDHIRRAVEGSLKRLKTDHIDLLYQHRPDPNVPIEDVAETVKALILEGKVKHWGLSE 219
Cdd:cd19144 78 IFLATKFGIeKNVETGEYSVDGSPEYVKKACETSLKRLGVDYIDLYYQHRVDGKTPIEKTVAAMAELVQEGKIKHIGLSE 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490304600 220 ASARTIRRAHAVLPVTAVQSEYAMW---WREPETRIFPTLEELGIGFVPYCPTARSFLAGAVNPSQRFDSTDRRHNLPRF 296
Cdd:cd19144 158 CSAETLRRAHAVHPIAAVQIEYSPFsldIERPEIGVLDTCRELGVAIVAYSPLGRGFLTGAIRSPDDFEEGDFRRMAPRF 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490304600 297 QPDALAKNMVLLEFAQSWARRKNTTPVQFALAWVMAQRPWIVPIPGTTQYPHLIENSGAPQVRLTDRELREIDAALAKIP 376
Cdd:cd19144 238 QAENFPKNLELVDKIKAIAKKKNVTAGQLTLAWLLAQGDDIIPIPGTTKLKRLEENLGALKVKLTEEEEKEIREIAEEAE 317
|
....*
gi 490304600 377 LQGGR 381
Cdd:cd19144 318 VVGER 322
|
|
| AKR_AKR11B3 |
cd19085 |
Synechococcus sp. aldo-keto reductase (SakR1) and similar proteins; Synechococcus sp. SakR1 is ... |
76-371 |
4.29e-87 |
|
Synechococcus sp. aldo-keto reductase (SakR1) and similar proteins; Synechococcus sp. SakR1 is a founding member of aldo-keto reductase family 11 member B3(AKR11B3). It is responsible for methylglyoxal detoxification.
Pssm-ID: 381311 [Multi-domain] Cd Length: 292 Bit Score: 265.60 E-value: 4.29e-87
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490304600 76 VSSMGLGCLPMVGYYGGGPRDRKAMVSLIRAAFEQGITFFDTAEVYGPHLSEEFVGEALAPVRDRVVIATKFGFGveegk 155
Cdd:cd19085 1 VSRLGLGCWQFGGGYWWGDQDDEESIATIHAALDAGINFFDTAEAYGDGHSEEVLGKALKGRRDDVVIATKVSPD----- 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490304600 156 ptslNSHPDHIRRAVEGSLKRLKTDHIDLLYQHRPDPNVPIEDVAETVKALILEGKVKHWGLSEASARTIRRAHAVLPVT 235
Cdd:cd19085 76 ----NLTPEDVRKSCERSLKRLGTDYIDLYQIHWPSSDVPLEETMEALEKLKEEGKIRAIGVSNFGPAQLEEALDAGRID 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490304600 236 AVQSEYAMWWREPETRIFPTLEELGIGFVPYCPTARSFLAGAVNPSQRFDSTDRRHNLPR-FQPDALAKNMVLLEFAQSW 314
Cdd:cd19085 152 SNQLPYNLLWRAIEYEILPFCREHGIGVLAYSPLAQGLLTGKFSSAEDFPPGDARTRLFRhFEPGAEEETFEALEKLKEI 231
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*...
gi 490304600 315 ARRKNTTPVQFALAWVMaQRPWIV-PIPGTTQYPHLIENSGAPQVRLTDRELREIDAA 371
Cdd:cd19085 232 ADELGVTMAQLALAWVL-QQPGVTsVIVGARNPEQLEENAAAVDLELSPSVLERLDEI 288
|
|
| AKR_AKR8A1-2 |
cd19077 |
AKR8A family of aldo-keto reductase (AKR); Schizosaccharomyces pombe PLR and PLR2 are founding ... |
72-369 |
9.26e-85 |
|
AKR8A family of aldo-keto reductase (AKR); Schizosaccharomyces pombe PLR and PLR2 are founding members of aldo-keto reductase family 8 member A1-2 (AKR8A1-2), respectively. PLR (EC 1.1.1.65), also called PL reductase (PL-red), catalyzes the reduction of pyridoxal (PL) with NADPH and oxidation of pyridoxine (PN) with NADP(+).
Pssm-ID: 381303 [Multi-domain] Cd Length: 302 Bit Score: 260.25 E-value: 9.26e-85
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490304600 72 GSLEVSSMGLGCLPMVGyyGGGPRDRKAMVSLIRAAFEQGITFFDTAEVYG---PHLSEEFVGEALA---PVRDRVVIAT 145
Cdd:cd19077 1 NGKLVGPIGLGLMGLTW--RPNPTPDEEAFETMKAALDAGSNLWNGGEFYGppdPHANLKLLARFFRkypEYADKVVLSV 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490304600 146 KFGFGVEEGKPTSlnsHPDHIRRAVEGSLKRLK-TDHIDLLYQHRPDPNVPIEDVAETVKALILEGKVKHWGLSEASART 224
Cdd:cd19077 79 KGGLDPDTLRPDG---SPEAVRKSIENILRALGgTKKIDIFEPARVDPNVPIEETIKALKELVKEGKIRGIGLSEVSAET 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490304600 225 IRRAHAVLPVTAVQSEYAMWWREPETR-IFPTLEELGIGFVPYCPTARSFLAGAVNPSQRFDSTDRRHNLPRFQPDALAK 303
Cdd:cd19077 156 IRRAHAVHPIAAVEVEYSLFSREIEENgVLETCAELGIPIIAYSPLGRGLLTGRIKSLADIPEGDFRRHLDRFNGENFEK 235
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 490304600 304 NMVLLEFAQSWARRKNTTPVQFALAWVMAQ-RPWIVPIPGTTQYPHLIENSGAPQVRLTDRELREID 369
Cdd:cd19077 236 NLKLVDALQELAEKKGCTPAQLALAWILAQsGPKIIPIPGSTTLERVEENLKAANVELTDEELKEIN 302
|
|
| AKR_AKR11B2 |
cd19149 |
Escherichia coli NADH-specific methylglyoxal reductase (YdjG) and similar proteins; ... |
68-370 |
8.30e-80 |
|
Escherichia coli NADH-specific methylglyoxal reductase (YdjG) and similar proteins; Escherichia coli YdjG is a founding member of aldo-keto reductase family 11 member B2 (AKR11B2). It catalyzes the NADH-dependent reduction of methylglyoxal (2-oxopropanal) in vitro. It may play some role in intestinal colonization.
Pssm-ID: 381375 [Multi-domain] Cd Length: 315 Bit Score: 247.96 E-value: 8.30e-80
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490304600 68 TRKLGS--LEVSSMGLGCLPMVGYYGGGPRDRKAMVSLIRAAFEQGITFFDTAEVYGPHLSEEFVGEALAPVRDRVVIAT 145
Cdd:cd19149 1 YRKLGKsgIEASVIGLGTWAIGGGPWWGGSDDNESIRTIHAALDLGINLIDTAPAYGFGHSEEIVGKAIKGRRDKVVLAT 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490304600 146 KFG----------FGVEEGKPTSLNSHPDHIRRAVEGSLKRLKTDHIDLLYQHRPDPNVPIEDVAETVKALILEGKVKHW 215
Cdd:cd19149 81 KCGlrwdreggsfFFVRDGVTVYKNLSPESIREEVEQSLKRLGTDYIDLYQTHWQDVETPIEETMEALEELKRQGKIRAI 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490304600 216 GLSEASARTIRRAHAVLPVTAVQSEYAMWWREPETRIFPTLEELGIGFVPYCPTARSFLAGAVNPSQRFDSTDRRHNLPR 295
Cdd:cd19149 161 GASNVSVEQIKEYVKAGQLDIIQEKYSMLDRGIEKELLPYCKKNNIAFQAYSPLEQGLLTGKITPDREFDAGDARSGIPW 240
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 490304600 296 FQPDALAKNMVLLEFAQSWARRKNTTPVQFALAWVMAQRPWIVPIPGTTQYPHLIENSGAPQVRLTDRELREIDA 370
Cdd:cd19149 241 FSPENREKVLALLEKWKPLCEKYGCTLAQLVIAWTLAQPGITSALCGARKPEQAEENAKAGDIRLSAEDIATMRS 315
|
|
| Aldo_ket_red |
pfam00248 |
Aldo/keto reductase family; This family includes a number of K+ ion channel beta chain ... |
103-372 |
4.95e-79 |
|
Aldo/keto reductase family; This family includes a number of K+ ion channel beta chain regulatory domains - these are reported to have oxidoreductase activity.
Pssm-ID: 425554 [Multi-domain] Cd Length: 290 Bit Score: 244.91 E-value: 4.95e-79
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490304600 103 LIRAAFEQGITFFDTAEVYGPHLSEEFVGEALAPV---RDRVVIATKFGFGVEEGKPtslNSHPDHIRRAVEGSLKRLKT 179
Cdd:pfam00248 23 ALRAALEAGINFIDTAEVYGDGKSEELLGEALKDYpvkRDKVVIATKVPDGDGPWPS---GGSKENIRKSLEESLKRLGT 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490304600 180 DHIDLLYQHRPDPNVPIEDVAETVKALILEGKVKHWGLSEASARTIRRA--HAVLPVTAVQSEYAMWWREPETRIFPTLE 257
Cdd:pfam00248 100 DYIDLYYLHWPDPDTPIEETWDALEELKKEGKIRAIGVSNFDAEQIEKAltKGKIPIVAVQVEYNLLRRRQEEELLEYCK 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490304600 258 ELGIGFVPYCPTARSFLAGAVNPSQRFDSTDRRHNLPRFQPdalaKNMVLLEFAQSWARRKNTTPVQFALAWVMAQRPWI 337
Cdd:pfam00248 180 KNGIPLIAYSPLGGGLLTGKYTRDPDKGPGERRRLLKKGTP----LNLEALEALEEIAKEHGVSPAQVALRWALSKPGVT 255
|
250 260 270
....*....|....*....|....*....|....*
gi 490304600 338 VPIPGTTQYPHLIENSGAPQVRLTDRELREIDAAL 372
Cdd:pfam00248 256 IPIPGASNPEQLEDNLGALEFPLSDEEVARIDELL 290
|
|
| AKR_AKR13B1 |
cd19088 |
AKR13B family of aldo-keto reductase (AKR); Xylella fastidiosa phenylacetaldehyde ... |
76-361 |
2.53e-76 |
|
AKR13B family of aldo-keto reductase (AKR); Xylella fastidiosa phenylacetaldehyde dehydrogenase is a founding member of aldo-keto reductase family 13 member B1 (AKR13B1). phenylacetaldehyde dehydrogenase (EC 1.2.1.39) catalyzes the NAD+-dependent oxidation of phenylactealdehyde to phenylacetic acid.
Pssm-ID: 381314 [Multi-domain] Cd Length: 256 Bit Score: 236.73 E-value: 2.53e-76
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490304600 76 VSSMGLGCLPMVGYYG-GGPRDRKAMVSLIRAAFEQGITFFDTAEVYGPHLSEEFVGEALAPVRDRVVIATKFGFGVEEG 154
Cdd:cd19088 1 VSRLGYGAMRLTGPGIwGPPADREEAIAVLRRALELGVNFIDTADSYGPDVNERLIAEALHPYPDDVVIATKGGLVRTGP 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490304600 155 KPTSLNSHPDHIRRAVEGSLKRLKTDHIDLLYQHRPDPNVPIEDVAETVKALILEGKVKHWGLSEASARTIRRAHAVLPV 234
Cdd:cd19088 81 GWWGPDGSPEYLRQAVEASLRRLGLDRIDLYQLHRIDPKVPFEEQLGALAELQDEGLIRHIGLSNVTVAQIEEARAIVRI 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490304600 235 TAVQSEYAMWWREPETrIFPTLEELGIGFVPYCPtarsfLAGAvnpsqrfdstdrrhnlprfqpdALAKNMVLLefaQSW 314
Cdd:cd19088 161 VSVQNRYNLANRDDEG-VLDYCEAAGIAFIPWFP-----LGGG----------------------DLAQPGGLL---AEV 209
|
250 260 270 280
....*....|....*....|....*....|....*....|....*..
gi 490304600 315 ARRKNTTPVQFALAWVMAQRPWIVPIPGTTQYPHLIENSGAPQVRLT 361
Cdd:cd19088 210 AARLGATPAQVALAWLLARSPVMLPIPGTSSVEHLEENLAAAGLRLS 256
|
|
| AKR_unchar |
cd19102 |
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ... |
76-372 |
1.11e-74 |
|
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.
Pssm-ID: 381328 [Multi-domain] Cd Length: 302 Bit Score: 234.10 E-value: 1.11e-74
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490304600 76 VSSMGLGCLPMVG---YYGGGPRDRKAMVSLIRAAFEQGITFFDTAEVYGPHLSEEFVGEALAPVRDRVVIATKFG-FGV 151
Cdd:cd19102 1 LTTIGLGTWAIGGggwGGGWGPQDDRDSIAAIRAALDLGINWIDTAAVYGLGHSEEVVGRALKGLRDRPIVATKCGlLWD 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490304600 152 EEGKPTSLNShPDHIRRAVEGSLKRLKTDHIDLLYQHRPDPNVPIEDVAETVKALILEGKVKHWGLSEASARTIRRAHAV 231
Cdd:cd19102 81 EEGRIRRSLK-PASIRAECEASLRRLGVDVIDLYQIHWPDPDEPIEEAWGALAELKEEGKVRAIGVSNFSVDQMKRCQAI 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490304600 232 LPVTAVQSEYAMWWREPETRIFPTLEELGIGFVPYCPTARSFLAGAVNPS--QRFDSTDRRHNLPRFQPDALAKNMVLLE 309
Cdd:cd19102 160 HPIASLQPPYSLLRRGIEAEILPFCAEHGIGVIVYSPMQSGLLTGKMTPErvASLPADDWRRRSPFFQEPNLARNLALVD 239
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 490304600 310 FAQSWARRKNTTPVQFALAWVMAqRPWIV-PIPGTTQYPHLIENSGAPQVRLTDRELREIDAAL 372
Cdd:cd19102 240 ALRPIAERHGRTVAQLAIAWVLR-RPEVTsAIVGARRPDQIDETVGAADLRLTPEELAEIEALL 302
|
|
| AKR_SF |
cd06660 |
Aldo-keto reductase (AKR) superfamily; Aldo-keto reductases (AKRs) are a superfamily of ... |
77-352 |
4.71e-70 |
|
Aldo-keto reductase (AKR) superfamily; Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications. Members have very distinct functions and include the prokaryotic 2,5-diketo-D-gluconic acid reductases and beta-keto ester reductases, the eukaryotic aldose reductases, aldehyde reductases, hydroxysteroid dehydrogenases, steroid 5beta-reductases, potassium channel beta-subunits, and aflatoxin aldehyde reductases, among others.
Pssm-ID: 381296 [Multi-domain] Cd Length: 232 Bit Score: 220.08 E-value: 4.71e-70
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490304600 77 SSMGLGCLPMvgyygGGPRDRKAMVSLIRAAFEQGITFFDTAEVYGPHLSEEFVGEALA--PVRDRVVIATKFGFGVEEG 154
Cdd:cd06660 1 SRLGLGTMTF-----GGDGDEEEAFALLDAALEAGGNFFDTADVYGDGRSERLLGRWLKgrGNRDDVVIATKGGHPPGGD 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490304600 155 KPTSLNShPDHIRRAVEGSLKRLKTDHIDLLYQHRPDPNVPIEDVAETVKALILEGKVKHWGLSEASARTIRRAHAVL-- 232
Cdd:cd06660 76 PSRSRLS-PEHIRRDLEESLRRLGTDYIDLYYLHRDDPSTPVEETLEALNELVREGKIRYIGVSNWSAERLAEALAYAka 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490304600 233 ----PVTAVQSEYAMWWREP-ETRIFPTLEELGIGFVPYCPTARsflaGavnpsqrfdstdrrhnlprfqpdalaknmvl 307
Cdd:cd06660 155 hglpGFAAVQPQYSLLDRSPmEEELLDWAEENGLPLLAYSPLAR----G------------------------------- 199
|
250 260 270 280
....*....|....*....|....*....|....*....|....*
gi 490304600 308 lefaqswarrknttPVQFALAWVMAQRPWIVPIPGTTQYPHLIEN 352
Cdd:cd06660 200 --------------PAQLALAWLLSQPFVTVPIVGARSPEQLEEN 230
|
|
| AKR_AKR11A1_11D1 |
cd19083 |
AKR11A and AKR11D families of aldo-keto reductase (AKR); Bacillus subtilis aldo-keto ... |
68-371 |
1.60e-69 |
|
AKR11A and AKR11D families of aldo-keto reductase (AKR); Bacillus subtilis aldo-keto reductase IolS, also called vegetative protein 147 (VEG147), is a founding member of aldo-keto reductase family 11 member A1 (AKR11A1). It is able to reduce the standard aldo-keto reductase (AKR) substrates DL-glyceraldehyde, D-erythrose, and methylglyoxal in the presence of NADPH, albeit with poor efficiency in vitro. Bacillus aryabhattai aldo keto reductase is a founding member of aldo-keto reductase family 11 member D1 (AKR11D1).
Pssm-ID: 381309 [Multi-domain] Cd Length: 307 Bit Score: 221.14 E-value: 1.60e-69
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490304600 68 TRKLG--SLEVSSMGLGclpmVGYYGGG---PR-DRKAMVSLIRAAFEQGITFFDTAEVYGPHLSEEFVGEALA-PVRDR 140
Cdd:cd19083 1 KVKLGksDIDVNPIGLG----TNAVGGHnlyPNlDEEEGKDLVREALDNGVNLLDTAFIYGLGRSEELVGEVLKeYNRNE 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490304600 141 VVIATKFGFGVEEGKpTSLNSHPDHIRRAVEGSLKRLKTDHIDLLYQHRPDPNVPIEDVAETVKALILEGKVKHWGLSEA 220
Cdd:cd19083 77 VVIATKGAHKFGGDG-SVLNNSPEFLRSAVEKSLKRLNTDYIDLYYIHFPDGETPKAEAVGALQELKDEGKIRAIGVSNF 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490304600 221 SARTIRRAHAVLPVTAVQSEYAMWWREPETRIFPTLEELGIGFVPYCPTARSFLAGAVNPSQRFDSTDRRHNLPRFQPDA 300
Cdd:cd19083 156 SLEQLKEANKDGYVDVLQGEYNLLQREAEEDILPYCVENNISFIPYFPLASGLLAGKYTKDTKFPDNDLRNDKPLFKGER 235
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 490304600 301 LAKNMVLLEFAQSWARRKNTTPVQFALAWVMAqRPWI-VPIPGTTQYPHLIENSGAPQVRLTDRELREIDAA 371
Cdd:cd19083 236 FSENLDKVDKLKSIADEKGVTVAHLALAWYLT-RPAIdVVIPGAKRAEQVIDNLKALDVTLTEEEIAFIDAL 306
|
|
| AKR_AKR12A1_B1_C1 |
cd19087 |
AKR12A, AKR12B, AKR12C families of aldo-keto reductase (AKR); Streptomyces fradiae TylCII, ... |
69-370 |
3.15e-67 |
|
AKR12A, AKR12B, AKR12C families of aldo-keto reductase (AKR); Streptomyces fradiae TylCII, Saccharopolyspora erythraea EryBII, and Streptomyces avermitilis aveBVIII are founding members of aldo-keto reductase family 12 member A1 (AKR12A1), B1 (AKR12B1), and C1(AKR12C1), respectively. TylCII acts as a NDP-hexose 2,3-enoyl reductase. EryBII is a mycarose/desosamine reductase involved in L-mycarose and D-desosamine production. aveBVIII functions as a dTDP-4-keto-6-deoxy-L-hexose-2,3-reductase.
Pssm-ID: 381313 [Multi-domain] Cd Length: 310 Bit Score: 215.51 E-value: 3.15e-67
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490304600 69 RKLG--SLEVSSMGLGCLPMvgyygGGPRDRKAMVSLIRAAFEQGITFFDTAEVYGPHLSEEFVGEALAPVRDRVVIATK 146
Cdd:cd19087 4 RTLGrtGLKVSRLCLGTMNF-----GGRTDEETSFAIMDRALDAGINFFDTADVYGGGRSEEIIGRWIAGRRDDIVLATK 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490304600 147 FGFGVEEGkPTSLNSHPDHIRRAVEGSLKRLKTDHIDLLYQHRPDPNVPIEdvaETVKA---LILEGKVKHWGLSE---- 219
Cdd:cd19087 79 VFGPMGDD-PNDRGLSRRHIRRAVEASLRRLQTDYIDLYQMHHFDRDTPLE---ETLRAlddLVRQGKIRYIGVSNfaaw 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490304600 220 --ASARTIRRAHAVLPVTAVQSEYAMWWREPETRIFPTLEELGIGFVPYCPTARSFLAGAVNPSQRFDSTDRRHNLPRFQ 297
Cdd:cd19087 155 qiAKAQGIAARRGLLRFVSEQPMYNLLKRQAELEILPAARAYGLGVIPYSPLAGGLLTGKYGKGKRPESGRLVERARYQA 234
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 490304600 298 PDALAKNMVLLEFAQSWARRKNTTPVQFALAWVMAQrPWIV-PIPGTTQYPHLIENSGAPQVRLTDRELREIDA 370
Cdd:cd19087 235 RYGLEEYRDIAERFEALAAEAGLTPASLALAWVLSH-PAVTsPIIGPRTLEQLEDSLAALEITLTPELLAEIDE 307
|
|
| AKR_AKR11C1 |
cd19086 |
AKR11C family of aldo-keto reductase (AKR); Bacillus subtilis uncharacterized oxidoreductase ... |
74-355 |
3.15e-65 |
|
AKR11C family of aldo-keto reductase (AKR); Bacillus subtilis uncharacterized oxidoreductase YqkF is a founding member of aldo-keto reductase family 11 member C1 (AKR11C1). It may function as oxidoreductase. This family also includes Bacillus halodurans AKR11C1, an NADPH-dependent 4-hydroxy-2,3-trans-nonenal reductase.
Pssm-ID: 381312 [Multi-domain] Cd Length: 238 Bit Score: 207.72 E-value: 3.15e-65
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490304600 74 LEVSSMGLGCLPMVGYYGGGPRDRKAmVSLIRAAFEQGITFFDTAEVYGPHLSEEFVGEALAPVRDRVVIATKFGFGVEE 153
Cdd:cd19086 1 LEVSEIGFGTWGLGGDWWGDVDDAEA-IRALRAALDLGINFFDTADVYGDGHSERLLGKALKGRRDKVVIATKFGNRFDG 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490304600 154 GKPTSLNSHPDHIRRAVEGSLKRLKTDHIDLLYQHRPDPNV-PIEDVAETVKALILEGKVKHWGLSEASARTIRRAHAVL 232
Cdd:cd19086 80 GPERPQDFSPEYIREAVEASLKRLGTDYIDLYQLHNPPDEVlDNDELFEALEKLKQEGKIRAYGVSVGDPEEALAALRRG 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490304600 233 PVTAVQSEYAMWWREPETRIFPTLEELGIGFVPYCPTARSFLAGavnpsqrfdstdrrhnlprfqpdalaknmvllefaq 312
Cdd:cd19086 160 GIDVVQVIYNLLDQRPEEELFPLAEEHGVGVIARVPLASGLLTG------------------------------------ 203
|
250 260 270 280
....*....|....*....|....*....|....*....|...
gi 490304600 313 swarrkntTPVQFALAWVMAQRPWIVPIPGTTQYPHLIENSGA 355
Cdd:cd19086 204 --------KLAQAALRFILSHPAVSTVIPGARSPEQVEENAAA 238
|
|
| AKR_EcYajO-like |
cd19079 |
Escherichia coli YajO and similar proteins; Escherichia coli YajO is the prototype of this ... |
70-369 |
6.38e-65 |
|
Escherichia coli YajO and similar proteins; Escherichia coli YajO is the prototype of this family. It is an uncharacterized aldo/keto reductase family oxidoreductase.
Pssm-ID: 381305 [Multi-domain] Cd Length: 312 Bit Score: 209.36 E-value: 6.38e-65
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490304600 70 KLGS--LEVSSMGLGClpmVGYygGGPRDRKAMV------SLIRAAFEQGITFFDTAEVYGPHLSEEFVGEAL---APvR 138
Cdd:cd19079 4 RLGNsgLKVSRLCLGC---MSF--GDPKWRPWVLdeeesrPIIKRALDLGINFFDTANVYSGGASEEILGRALkefAP-R 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490304600 139 DRVVIATKFGFGVEEGKPTSLNSHpDHIRRAVEGSLKRLKTDHIDLLYQHRPDPNVPIEDVAETVKALILEGKVKHWGLS 218
Cdd:cd19079 78 DEVVIATKVYFPMGDGPNGRGLSR-KHIMAEVDASLKRLGTDYIDLYQIHRWDYETPIEETLEALHDVVKSGKVRYIGAS 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490304600 219 E------ASARTIRRAHAVLPVTAVQSEYAMWWREPETRIFPTLEELGIGFVPYCPTARSFLAGAVNPSQRFDSTDRRhn 292
Cdd:cd19079 157 SmyawqfAKALHLAEKNGWTKFVSMQNHYNLLYREEEREMIPLCEEEGIGVIPWSPLARGRLARPWGDTTERRRSTTD-- 234
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 490304600 293 LPRFQPDALA-KNMVLLEFAQSWARRKNTTPVQFALAWVMAQRPWIVPIPGTTQYPHLIENSGAPQVRLTDRELREID 369
Cdd:cd19079 235 TAKLKYDYFTeADKEIVDRVEEVAKERGVSMAQVALAWLLSKPGVTAPIVGATKLEHLEDAVAALDIKLSEEEIKYLE 312
|
|
| AKR_AKR3F1-like |
cd19072 |
Thermotoga maritime Tm1743, Escherichia coli YeaE and similar proteins; Thermotoga maritime ... |
75-369 |
2.26e-64 |
|
Thermotoga maritime Tm1743, Escherichia coli YeaE and similar proteins; Thermotoga maritime Tm1743 is a founding member of aldo-keto reductase family 3 member F1 (AKR3F1). It is a aldo/keto reductase family oxidoreductase. Escherichia coli YeaE may act as an aldo-keto reductase (AKR) that catalyzes the reversible reduction of ketones to the respective alcohols using NAD(P)H as a hydride donor.
Pssm-ID: 381298 [Multi-domain] Cd Length: 263 Bit Score: 206.31 E-value: 2.26e-64
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490304600 75 EVSSMGLGCLPMVGYYGGGPRDRKAMVSLIRAAFEQGITFFDTAEVYGPHLSEEFVGEALAPV-RDRVVIATKFgfgvee 153
Cdd:cd19072 3 EVPVLGLGTWGIGGGMSKDYSDDKKAIEALRYAIELGINLIDTAEMYGGGHAEELVGKAIKGFdREDLFITTKV------ 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490304600 154 gkpTSLNSHPDHIRRAVEGSLKRLKTDHIDlLYQ-HRPDPNVPIEDVAETVKALILEGKVKHWGLSEASARTIRRAHAVL 232
Cdd:cd19072 77 ---SPDHLKYDDVIKAAKESLKRLGTDYID-LYLiHWPNPSIPIEETLRAMEELVEEGKIRYIGVSNFSLEELEEAQSYL 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490304600 233 ---PVTAVQSEYAMWWREPETRIFPTLEELGIGFVPYCPTARSFLAGAvnpsqrfdstdrrhnlprfqpdalaknmVLLE 309
Cdd:cd19072 153 kkgPIVANQVEYNLFDREEESGLLPYCQKNGIAIIAYSPLEKGKLSNA----------------------------KGSP 204
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|
gi 490304600 310 FAQSWARRKNTTPVQFALAWVMaQRPWIVPIPGTTQYPHLIENSGAPQVRLTDRELREID 369
Cdd:cd19072 205 LLDEIAKKYGKTPAQIALNWLI-SKPNVIAIPKASNIEHLEENAGALGWELSEEDLQRLD 263
|
|
| Aldo_ket_red_shaker-like |
cd19074 |
Shaker potassium channel beta subunit family and similar proteins; This family includes ... |
74-362 |
5.74e-63 |
|
Shaker potassium channel beta subunit family and similar proteins; This family includes voltage-gated potassium channel subunits, beta-1 (KCAB1B), beta-2 (KCAB2B) and beta-3 (KCAB3B). KCAB1B and KCAB2B are cytoplasmic potassium channel subunits that modulate the characteristics of the channel-forming alpha-subunits. KCAB3B is an accessory potassium channel protein which modulates the activity of the pore-forming alpha subunit. The family also includes Drosophila melanogaster Hk protein, a founding member of aldo-keto reductase family 6 member B1 (AKR6B1), as well as voltage-gated potassium channel subunit beta (KCAB) from Arabidopsis thaliana and Egeria densa, founding members of AKR6C1and AKR6C2, respectively. Hk protein, also called hyperkinetic, is a beta subunit of Shaker (Sh) K+ channels and shows high sequence homology to aldoketoreductase. KCAB, also called Shaker channel b-subunit, or K(+) channel subunit beta, or potassium voltage beta 1, or KV-beta1, or KAB1, is a probable accessory potassium channel protein which modulates the activity of the pore-forming alpha subunit.
Pssm-ID: 381300 [Multi-domain] Cd Length: 297 Bit Score: 203.98 E-value: 5.74e-63
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490304600 74 LEVSSMGLGCLPMVGyyggGPRDRKAMVSLIRAAFEQGITFFDTAEVYGPHLSEEFVGEALAPV-RDRVVIATKFGFGVE 152
Cdd:cd19074 2 LKVSELSLGTWLTFG----GQVDDEDAKACVRKAYDLGINFFDTADVYAAGQAEEVLGKALKGWpRESYVISTKVFWPTG 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490304600 153 EGKPTSLNSHPdHIRRAVEGSLKRLKTDHIDLLYQHRPDPNVPIEDVAETVKALILEGKVKHWGLSEASARTIRRAHAV- 231
Cdd:cd19074 78 PGPNDRGLSRK-HIFESIHASLKRLQLDYVDIYYCHRYDPETPLEETVRAMDDLIRQGKILYWGTSEWSAEQIAEAHDLa 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490304600 232 -----LPVTAVQSEYAMWWREPETRIFPTLEELGIGFVPYCPTARSFLAG-----AVNPSQRF--DSTDRRHNLPRFQPD 299
Cdd:cd19074 157 rqfglIPPVVEQPQYNMLWREIEEEVIPLCEKNGIGLVVWSPLAQGLLTGkyrdgIPPPSRSRatDEDNRDKKRRLLTDE 236
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 490304600 300 ALAKNMVLLEFAQswarRKNTTPVQFALAWVMAQRPWIVPIPGTTQYPHLIENSGAPQVRLTD 362
Cdd:cd19074 237 NLEKVKKLKPIAD----ELGLTLAQLALAWCLRNPAVSSAIIGASRPEQLEENVKASGVKLSP 295
|
|
| AKR_AKR11B1 |
cd19148 |
Bacillus subtilis aldo-keto reductase YhdN and similar proteins; Bacillus subtilis YhdN, also ... |
74-372 |
7.13e-62 |
|
Bacillus subtilis aldo-keto reductase YhdN and similar proteins; Bacillus subtilis YhdN, also called general stress protein 69 (GSP69), is a founding member of aldo-keto reductase family 11 member B1 (AKR11B1). It acts as an aldo-keto reductase (AKR) that catalyzes the reversible reduction of ketones to the respective alcohols using NAD(P)H as a hydride donor.
Pssm-ID: 381374 [Multi-domain] Cd Length: 302 Bit Score: 201.38 E-value: 7.13e-62
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490304600 74 LEVSSMGLGCLPMVGYYGGGPRDRKAmVSLIRAAFEQGITFFDTAEVYGPHLSEEFVGEALA--PVRDRVVIATKFGFGV 151
Cdd:cd19148 2 LPVSRIALGTWAIGGWMWGGTDEKEA-IETIHKALDLGINLIDTAPVYGFGLSEEIVGKALKeyGKRDRVVIATKVGLEW 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490304600 152 EEGKPTSLNSHPDHIRRAVEGSLKRLKTDHIDlLYQ-HRPDPNVPIEDVAETVKALILEGKVKHWGLSEASARTIRRAHA 230
Cdd:cd19148 81 DEGGEVVRNSSPARIRKEVEDSLRRLQTDYID-LYQvHWPDPLVPIEETAEALKELLDEGKIRAIGVSNFSPEQMETFRK 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490304600 231 VLPVTAVQSEYAMWWREPETRIFPTLEELGIGFVPYCPTARSFLAGAVNPSQRFDSTDRRHNLPRFQPDALAKNMVLLEF 310
Cdd:cd19148 160 VAPLHTVQPPYNLFEREIEKDVLPYARKHNIVTLAYGALCRGLLSGKMTKDTKFEGDDLRRTDPKFQEPRFSQYLAAVEE 239
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 490304600 311 AQSWARRKNTTPV-QFALAWVMAQRPWIVPIPGTTQYPHLIENSGAPQVRLTDRELREIDAAL 372
Cdd:cd19148 240 LDKLAQERYGKSViHLAVRWLLDQPGVSIALWGARKPEQLDAVDEVFGWSLNDEDMKEIDAIL 302
|
|
| AKR_AKR9A_9B |
cd19080 |
AKR9A and AKR9B families of aldo-keto reductase (AKR); The AKR9A family includes Aspergillus ... |
69-369 |
3.60e-61 |
|
AKR9A and AKR9B families of aldo-keto reductase (AKR); The AKR9A family includes Aspergillus nidulans sterigmatocystin biosynthesis dehydrogenase StcV, Aspergillus flavus norsolorinic acid reductase (NOR), and Phanerochaete chrysosporium aryl-alcohol dehydrogenase [NADP(+)] (AAD), are founding members of aldo-keto reductase family 9 member A1-3 (AKR9A1-3), respectively. StcV may be involved in the dehydration of 5'-hydroxyaverantin to form averufin. NOR is involved in aflatoxin biosynthesis. AAD (EC1.1.1.91) is involved in lignin degradation and reduces aromatic benzaldehydes to their respective alcohols in the presence of NADP(H). The AKR9B family includes Saccharomyces cerevisiae aryl-alcohol dehydrogenases AAD14p, AAD3p, AAD4p, and AAD10p, which are founding members of aldo-keto reductase family 9 member B1-4 (AKR9B1-4), respectively.
Pssm-ID: 381306 [Multi-domain] Cd Length: 307 Bit Score: 199.75 E-value: 3.60e-61
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490304600 69 RKLGS--LEVSSMGLGCLPMVGYYGGG--PRDRKAMVsliRAAFEQGITFFDTAEVYGPHLSEEFVGEALAPVRDRVVIA 144
Cdd:cd19080 1 RLLGRsgLRVSPLALGTMTFGTEWGWGadREEARAMF---DAYVEAGGNFIDTANNYTNGTSERLLGEFIAGNRDRIVLA 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490304600 145 TKFGFGVEEGKPTSLNSHPDHIRRAVEGSLKRLKTDHIDLLYQHRPDPNVPIEDVAETVKALILEGKVKHWGLSE----- 219
Cdd:cd19080 78 TKYTMNRRPGDPNAGGNHRKNLRRSVEASLRRLQTDYIDLLYVHAWDFTTPVEEVMRALDDLVRAGKVLYVGISDtpawv 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490304600 220 -ASARTIRRAHAVLPVTAVQSEYAMWWREPETRIFPTLEELGIGFVPYCPTARSFLAGAVNPSQRfdSTDRRHNLPRFQP 298
Cdd:cd19080 158 vARANTLAELRGWSPFVALQIEYSLLERTPERELLPMARALGLGVTPWSPLGGGLLTGKYQRGEE--GRAGEAKGVTVGF 235
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 490304600 299 DAL-AKNMVLLEFAQSWARRKNTTPVQFALAWVMAQRPWIVPIPGTTQYPHLIENSGAPQVRLTDRELREID 369
Cdd:cd19080 236 GKLtERNWAIVDVVAAVAEELGRSAAQVALAWVRQKPGVVIPIIGARTLEQLKDNLGALDLTLSPEQLARLD 307
|
|
| AKR_AtPLR-like |
cd19093 |
Arabidopsis thaliana pyridoxal reductase (PLR) and similar proteins; Arabidopsis thaliana PLR ... |
75-369 |
2.05e-57 |
|
Arabidopsis thaliana pyridoxal reductase (PLR) and similar proteins; Arabidopsis thaliana PLR (EC 1.1.1.65) is the prototype of this family. It catalyzes the reduction of pyridoxal (PL) with NADPH and oxidation of pyridoxine (PN) with NADP(+), and is involved in the PLP salvage pathway.
Pssm-ID: 381319 [Multi-domain] Cd Length: 293 Bit Score: 189.36 E-value: 2.05e-57
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490304600 75 EVSSMGLGCLPM--VGYYGGGPRDRKAMVSLIRAAFEQGITFFDTAEVYGPHLSEEFVGEALA--PVRDRVVIATKFGfg 150
Cdd:cd19093 1 EVSPLGLGTWQWgdRLWWGYGEYGDEDLQAAFDAALEAGVNLFDTAEVYGTGRSERLLGRFLKelGDRDEVVIATKFA-- 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490304600 151 veegkPTSLNSHPDHIRRAVEGSLKRLKTDHIDLLYQHRPDPNVP-IEDVAETVKALILEGKVKHWGLSEASARTIRRAH 229
Cdd:cd19093 79 -----PLPWRLTRRSVVKALKASLERLGLDSIDLYQLHWPGPWYSqIEALMDGLADAVEEGLVRAVGVSNYSADQLRRAH 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490304600 230 AVL-----PVTAVQSEYAMWWREPETR-IFPTLEELGIGFVPYCPTARSFLAGAVNPSQRFDSTDRRHNLPRFqpdaLAK 303
Cdd:cd19093 154 KALkergvPLASNQVEYSLLYRDPEQNgLLPACDELGITLIAYSPLAQGLLTGKYSPENPPPGGRRRLFGRKN----LEK 229
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 490304600 304 NMVLLEFAQSWARRKNTTPVQFALAWVMAQrpWIVPIPGTTQYPHLIENSGAPQVRLTDRELREID 369
Cdd:cd19093 230 VQPLLDALEEIAEKYGKTPAQVALNWLIAK--GVVPIPGAKNAEQAEENAGALGWRLSEEEVAELD 293
|
|
| AKR_AKR9C1 |
cd19081 |
AKR9C family of aldo-keto reductase (AKR); Haloferax volcanii aldo-keto reductase is a ... |
74-369 |
1.16e-56 |
|
AKR9C family of aldo-keto reductase (AKR); Haloferax volcanii aldo-keto reductase is a founding member of aldo-keto reductase family 9 member C1 (AKR9C1).
Pssm-ID: 381307 [Multi-domain] Cd Length: 308 Bit Score: 187.81 E-value: 1.16e-56
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490304600 74 LEVSSMGLGClpMVGyygGGPRDRKAMVSLIRAAFEQGITFFDTAEVYGPH-------LSEEFVGEALA--PVRDRVVIA 144
Cdd:cd19081 7 LSVSPLCLGT--MVF---GWTADEETSFALLDAFVDAGGNFIDTADVYSAWvpgnaggESETIIGRWLKsrGKRDRVVIA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490304600 145 TKFGFGVEEGKPtslNSHPDHIRRAVEGSLKRLKTDHIDLLYQHRPDPNVPIEDVAETVKALILEGKVKHWGLSEASART 224
Cdd:cd19081 82 TKVGFPMGPNGP---GLSRKHIRRAVEASLRRLQTDYIDLYQAHWDDPATPLEETLGALNDLIRQGKVRYIGASNYSAWR 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490304600 225 IRRA------HAVLPVTAVQSEYAMWWREP-ETRIFPTLEELGIGFVPYCPTARSFLAGAVNPSQRFDSTDRRH-NLPRF 296
Cdd:cd19081 159 LQEAlelsrqHGLPRYVSLQPEYNLVDRESfEGELLPLCREEGIGVIPYSPLAGGFLTGKYRSEADLPGSTRRGeAAKRY 238
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 490304600 297 QPDalaKNMVLLEFAQSWARRKNTTPVQFALAWVMAqRPWI-VPIPGTTQYPHLIENSGAPQVRLTDRELREID 369
Cdd:cd19081 239 LNE---RGLRILDALDEVAAEHGATPAQVALAWLLA-RPGVtAPIAGARTVEQLEDLLAAAGLRLTDEEVARLD 308
|
|
| AKR_PsAKR |
cd19091 |
Polaromonas Sp. aldo-keto reductase and similar proteins; The prototype of this family is an ... |
69-371 |
4.21e-56 |
|
Polaromonas Sp. aldo-keto reductase and similar proteins; The prototype of this family is an uncharacterized aldo-keto reductase from Polaromonas sp.
Pssm-ID: 381317 [Multi-domain] Cd Length: 319 Bit Score: 186.66 E-value: 4.21e-56
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490304600 69 RKLGS--LEVSSMGLGCL------PMVGYYGGgpRDRKAMVSLIRAAFEQGITFFDTAEVYGPHLSEEFVGEALAPVRDR 140
Cdd:cd19091 4 RTLGRsgLKVSELALGTMtfggggGFFGAWGG--VDQEEADRLVDIALDAGINFFDTADVYSEGESEEILGKALKGRRDD 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490304600 141 VVIATKFGFGVEEGkPTSLNSHPDHIRRAVEGSLKRLKTDHIDLLYQHRPDPNVPIEDVAETVKALILEGKVKHWGLSEA 220
Cdd:cd19091 82 VLIATKVRGRMGEG-PNDVGLSRHHIIRAVEASLKRLGTDYIDLYQLHGFDALTPLEETLRALDDLVRQGKVRYIGVSNF 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490304600 221 SARTIRRAHAV------LPVTAVQSEYAMWWREPETRIFPTLEELGIGFVPYCPTARSFLAGAVNPSQRFDSTDRRHNLP 294
Cdd:cd19091 161 SAWQIMKALGIserrglARFVALQAYYSLLGRDLEHELMPLALDQGVGLLVWSPLAGGLLSGKYRRGQPAPEGSRLRRTG 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490304600 295 RFQP---DALAKNMV--LLEFAQswarRKNTTPVQFALAWVMAQRPWIVPIPGTTQYPHLIENSGAPQVRLTDRELREID 369
Cdd:cd19091 241 FDFPpvdRERGYDVVdaLREIAK----ETGATPAQVALAWLLSRPTVSSVIIGARNEEQLEDNLGAAGLSLTPEEIARLD 316
|
..
gi 490304600 370 AA 371
Cdd:cd19091 317 KV 318
|
|
| AKR_AKR6C1_2 |
cd19143 |
AKR6C family of aldo-keto reductase (AKR); Voltage-gated potassium channel subunit beta (KCAB) ... |
69-371 |
7.32e-50 |
|
AKR6C family of aldo-keto reductase (AKR); Voltage-gated potassium channel subunit beta (KCAB) from Arabidopsis thaliana and Egeria densa are founding members of aldo-keto reductase family 6 member C1 (AKR6C1) and C2 (AKR6C2), respectively. KCAB, also called Shaker channel b-subunit, or K(+) channel subunit beta, or potassium voltage beta 1, or KV-beta1, or KAB1, is a probable accessory potassium channel protein which modulates the activity of the pore-forming alpha subunit.
Pssm-ID: 381369 [Multi-domain] Cd Length: 319 Bit Score: 170.47 E-value: 7.32e-50
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490304600 69 RKLGS--LEVSSMGLGClpMVGYygGGPRDRKAMVSLIRAAFEQGITFFDTAEVYGPHLSEEFVGEALAPV---RDRVVI 143
Cdd:cd19143 4 RRLGRsgLKVSALSFGS--WVTF--GNQVDVDEAKECMKAAYDAGVNFFDNAEVYANGQSEEIMGQAIKELgwpRSDYVV 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490304600 144 ATKFGFGVEEGKPTSLNSHPDHIRRAVEGSLKRLKTDHIDLLYQHRPDPNVPIEdvaETVKA---LILEGKVKHWGLSEA 220
Cdd:cd19143 80 STKIFWGGGGPPPNDRGLSRKHIVEGTKASLKRLQLDYVDLVFCHRPDPATPIE---ETVRAmndLIDQGKAFYWGTSEW 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490304600 221 SARTIRRAHAV------LPVTAVQSEYAMWWREP-ETRIFPTLEELGIGFVPYCPTARSFLAGAVN----PSQRFDSTDR 289
Cdd:cd19143 157 SAQQIEEAHEIadrlglIPPVMEQPQYNLFHRERvEVEYAPLYEKYGLGTTTWSPLASGLLTGKYNngipEGSRLALPGY 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490304600 290 RHNLPRFQPDALAKNMVLLEFAQSwARRKNTTPVQFALAWVmAQRPWI--VpIPGTTQYPHLIENSGAPQV--RLTDREL 365
Cdd:cd19143 237 EWLKDRKEELGQEKIEKVRKLKPI-AEELGCSLAQLAIAWC-LKNPNVstV-ITGATKVEQLEENLKALEVlpKLTPEVM 313
|
....*.
gi 490304600 366 REIDAA 371
Cdd:cd19143 314 EKIEAI 319
|
|
| AKR_BsYcsN_EcYdhF-like |
cd19092 |
Bacillus subtilis YcsN, Escherichia coli YdhF and similar proteins; Bacillus subtilis YcsN and ... |
74-364 |
3.14e-47 |
|
Bacillus subtilis YcsN, Escherichia coli YdhF and similar proteins; Bacillus subtilis YcsN and Escherichia coli YdhF are prototypes of this family. They are uncharacterized aldo/keto reductase family oxidoreductases.
Pssm-ID: 381318 [Multi-domain] Cd Length: 287 Bit Score: 162.73 E-value: 3.14e-47
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490304600 74 LEVSSMGLGCLPMvgyyGGGPRDRKAMVSLIRAAFEQGITFFDTAEVYGPHLSEEFVGEALA---PVRDRVVIATK---- 146
Cdd:cd19092 4 LEVSRLVLGCMRL----ADWGESAEELLSLIEAALELGITTFDHADIYGGGKCEELFGEALAlnpGLREKIEIQTKcgir 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490304600 147 FGFGVEEGKPTSLNSHPDHIRRAVEGSLKRLKTDHIDLLYQHRPDPNVPIEDVAETVKALILEGKVKHWGLSEASARTIR 226
Cdd:cd19092 80 LGDDPRPGRIKHYDTSKEHILASVEGSLKRLGTDYLDLLLLHRPDPLMDPEEVAEAFDELVKSGKVRYFGVSNFTPSQIE 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490304600 227 --RAHAVLPVTAVQSEYAMWWREP-ETRIFPTLEELGIGFVPYCPTARSFLAGAvnpsqrfdstdrrhNLPRFQPdalak 303
Cdd:cd19092 160 llQSYLDQPLVTNQIELSLLHTEAiDDGTLDYCQLLDITPMAWSPLGGGRLFGG--------------FDERFQR----- 220
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 490304600 304 nmvLLEFAQSWARRKNTTPVQFALAWVMAQRPWIVPIPGTTQYPHLIENSGAPQVRLTdRE 364
Cdd:cd19092 221 ---LRAALEELAEEYGVTIEAIALAWLLRHPARIQPILGTTNPERIRSAVKALDIELT-RE 277
|
|
| AKR_YeaE |
cd19138 |
Escherichia coli YeaE and similar proteins; Escherichia coli YeaE is the prototype of this ... |
68-369 |
2.40e-46 |
|
Escherichia coli YeaE and similar proteins; Escherichia coli YeaE is the prototype of this family. It acts as an aldo-keto reductase (AKR) that catalyzes the reversible reduction of ketones to the respective alcohols using NAD(P)H as a hydride donor.
Pssm-ID: 381364 [Multi-domain] Cd Length: 266 Bit Score: 159.72 E-value: 2.40e-46
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490304600 68 TRKLGSLE-VSSMGLGCLPMvgyyGGGPRDRKAMVSLIRAAFEQGITFFDTAEVYGPHLSEEFVGEALAPVRDRVVIATK 146
Cdd:cd19138 2 TVTLPDGTkVPALGQGTWYM----GEDPAKRAQEIEALRAGIDLGMTLIDTAEMYGDGGSEELVGEAIRGRRDKVFLVSK 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490304600 147 FgfgveegKPTslNSHPDHIRRAVEGSLKRLKTDHIDLLYQHRPDpNVPIEDVAETVKALILEGKVKHWGLSEASARTIR 226
Cdd:cd19138 78 V-------LPS--NASRQGTVRACERSLRRLGTDYLDLYLLHWRG-GVPLAETVAAMEELKKEGKIRAWGVSNFDTDDME 147
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490304600 227 RAHAVL---PVTAVQSEYAMWWREPETRIFPTLEELGIGFVPYCPTARSflagavnpsqrfdstdrrhnlpRFQPDALAK 303
Cdd:cd19138 148 ELWAVPgggNCAANQVLYNLGSRGIEYDLLPWCREHGVPVMAYSPLAQG----------------------GLLRRGLLE 205
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 490304600 304 NMVLlefaQSWARRKNTTPVQFALAWVMAQrPWIVPIPGTTQYPHLIENSGAPQVRLTDRELREID 369
Cdd:cd19138 206 NPTL----KEIAARHGATPAQVALAWVLRD-GNVIAIPKSGSPEHARENAAAADLELTEEDLAELD 266
|
|
| AKR_Tas-like |
cd19094 |
Escherichia coli Tas protein and similar proteins; Escherichia coli Tas protein is the ... |
107-370 |
5.72e-45 |
|
Escherichia coli Tas protein and similar proteins; Escherichia coli Tas protein is the prototype of this family. It is an NADP(H)-dependent aldo-keto reductase that catalyzes the reversible reduction of ketones to the respective alcohols using NADP(H) as a hydride donor.
Pssm-ID: 381320 [Multi-domain] Cd Length: 328 Bit Score: 157.73 E-value: 5.72e-45
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490304600 107 AFEQGITFFDTAEVY-------GPHLSEEFVGEALA--PVRDRVVIATKF-----GFGVEEGKPTSLNshPDHIRRAVEG 172
Cdd:cd19094 27 AFDEGVNFIDTAEMYpvppspeTQGRTEEIIGSWLKkkGNRDKVVLATKVagpgeGITWPRGGGTRLD--RENIREAVEG 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490304600 173 SLKRLKTDHIDLLYQHRPDPNVP------------------IEDVAETVKALILEGKVKHWGLSEASA----RTIR--RA 228
Cdd:cd19094 105 SLKRLGTDYIDLYQLHWPDRYTPlfgggyytepseeedsvsFEEQLEALGELVKAGKIRHIGLSNETPwgvmKFLElaEQ 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490304600 229 HAVLPVTAVQSEYAMWWREPETrifpTLEEL----GIGFVPYCPTARSFLAGAVNPSQRFDSTDR----RHNLPRF-QPD 299
Cdd:cd19094 185 LGLPRIVSIQNPYSLLNRNFEE----GLAEAchreNVGLLAYSPLAGGVLTGKYLDGAARPEGGRlnlfPGYMARYrSPQ 260
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 490304600 300 ALAKNMVLLEFAQSWarrkNTTPVQFALAWVmAQRPWIVP-IPGTTQYPHLIENSGAPQVRLTDRELREIDA 370
Cdd:cd19094 261 ALEAVAEYVKLARKH----GLSPAQLALAWV-RSRPFVTStIIGATTLEQLKENIDAFDVPLSDELLAEIDA 327
|
|
| AKR_AKR14A1_2 |
cd19089 |
AKR14A family of aldo-keto reductase (AKR); Escherichia coli L-glyceraldehyde 3-phosphate ... |
74-365 |
2.04e-44 |
|
AKR14A family of aldo-keto reductase (AKR); Escherichia coli L-glyceraldehyde 3-phosphate reductase (GPR/YghZ), also called GAP reductase, is a founding member of aldo-keto reductase family 14 member A1 (AKR14A1). It catalyzes the stereospecific, NADPH-dependent reduction of L-glyceraldehyde 3-phosphate (L-GAP). It is also involved in the stress response as a methylglyoxal reductase which converts the toxic metabolite methylglyoxal to acetol in vitro and in vivo. Salmonella enterica AKR is a founding member of aldo-keto reductase family 14 member A2 (AKR14A2). It catalyzes the conversion of 3-hydroxybutanal (3-HB) to 1,3-butanediol (1,3-BDO) by using NADPH as a cofactor.
Pssm-ID: 381315 [Multi-domain] Cd Length: 308 Bit Score: 155.88 E-value: 2.04e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490304600 74 LEVSSMGLGCLPmvgyygGGPRDRKAMVSLIRAAFEQGITFFDTAEVYGPH--LSEEFVGEAL----APVRDRVVIATKF 147
Cdd:cd19089 11 LPAISLGLWHNF------GDYTSPEEARELLRTAFDLGITHFDLANNYGPPpgSAEENFGRILkrdlRPYRDELVISTKA 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490304600 148 GFGVEEGkPTSLNSHPDHIRRAVEGSLKRLKTDHIDLLYQHRPDPNVPIEDVAETVKALILEGKVKHWGLSEASARTIRR 227
Cdd:cd19089 85 GYGMWPG-PYGDGGSRKYLLASLDQSLKRMGLDYVDIFYHHRYDPDTPLEETMTALADAVRSGKALYVGISNYPGAKARR 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490304600 228 AHAVL-----PVTAVQSEYAMWWREPETRIFPTLEELGIGFVPYCPTARSFLAGAvnPSQRFDSTDRRHNLPRFQPDAL- 301
Cdd:cd19089 164 AIALLrelgvPLIIHQPRYSLLDRWAEDGLLEVLEEAGIGFIAFSPLAQGLLTDK--YLNGIPPDSRRAAESKFLTEEAl 241
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 490304600 302 --AKNMVLLEFAQsWARRKNTTPVQFALAWVMaQRPWI--VPIpGTTQYPHLIENSGA-PQVRLTDREL 365
Cdd:cd19089 242 tpEKLEQLRKLNK-IAAKRGQSLAQLALSWVL-RDPRVtsVLI-GASSPSQLEDNVAAlKNLDFSEEEL 307
|
|
| YdhF |
COG4989 |
Predicted oxidoreductase YdhF [General function prediction only]; |
74-364 |
1.23e-43 |
|
Predicted oxidoreductase YdhF [General function prediction only];
Pssm-ID: 444013 [Multi-domain] Cd Length: 299 Bit Score: 153.38 E-value: 1.23e-43
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490304600 74 LEVSSMGLGCLPMvgyyGGGPRDRKAMVSLIRAAFEQGITFFDTAEVYGPHLSEEFVGEALA--PV-RDRVVIATKFG-- 148
Cdd:COG4989 11 LSVSRIVLGCMRL----GEWDLSPAEAAALIEAALELGITTFDHADIYGGYTCEALFGEALKlsPSlREKIELQTKCGir 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490304600 149 --FGVEEGKPTSLNSHPDHIRRAVEGSLKRLKTDHIDLLYQHRPDPNVPIEDVAETVKALILEGKVKHWGLSEASARTIR 226
Cdd:COG4989 87 lpSEARDNRVKHYDTSKEHIIASVEGSLRRLGTDYLDLLLLHRPDPLMDPEEVAEAFDELKASGKVRHFGVSNFTPSQFE 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490304600 227 --RAHAVLPVTAVQSEYAMWWREPetrIFP-TLEelgigfvpYC------PTARSFLAGAvnpsqRFDSTDRrhnlprfq 297
Cdd:COG4989 167 llQSALDQPLVTNQIELSLLHTDA---FDDgTLD--------YCqlngitPMAWSPLAGG-----RLFGGFD-------- 222
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490304600 298 PDALAKNMVLLEFAQswarRKNTTPVQFALAWVM---AQrpwIVPIPGTTQYPHLIENSGAPQVRLTdRE 364
Cdd:COG4989 223 EQFPRLRAALDELAE----KYGVSPEAIALAWLLrhpAG---IQPVIGTTNPERIKAAAAALDIELT-RE 284
|
|
| AKR_AKR7A1-5 |
cd19075 |
AKR7A family of aldo-keto reductase (AKR); Aflatoxin B1 aldehyde reductase member 1/3 (AKR7A1 ... |
81-331 |
2.08e-43 |
|
AKR7A family of aldo-keto reductase (AKR); Aflatoxin B1 aldehyde reductase member 1/3 (AKR7A1/AKR7A3/AFAR) from Rattus norvegicus, aflatoxin B1 aldehyde reductase member 2 (AKR7A2/AFAR1/AFAR) and aflatoxin B1 aldehyde reductase member 3 (AKR7A3/AFAR2) from Homo sapiens, aflatoxin B1 aldehyde reductase member 2 (AKR7A2/AFAR2) from Rattus norvegicus, and aflatoxin B1 aldehyde reductase member 2 (AKR7A2/AKR7A5/AFAR) from Mus musculus, are founding members of aldo-keto reductase family 7 member A1-5 (AKR7A1-5), respectively. AKR7A2 (EC 1.1.1.n11), also called AFB1 aldehyde reductase 1, or AFB1-AR 1, or aldoketoreductase 7, or succinic semialdehyde reductase, or SSA reductase, catalyzes the NADPH-dependent reduction of succinic semialdehyde to gamma-hydroxybutyrate (GHB). It has NADPH-dependent aldehyde reductase activity towards 2-carboxybenzaldehyde, 2-nitrobenzaldehyde and pyridine-2-aldehyde (in vitro). AKR7A2, AKR7A3 (also called AFB1 aldehyde reductase 2 or AFB1-AR 2), and AKR7A4 (also called AFB1 aldehyde reductase 3, or AFB1-AR 3, or aldoketoreductase 7-like), may be involved in protection of liver against the toxic and carcinogenic effects of aflatoxin B1 (AFB1), a potent hepatocarcinogen. They can reduce the dialdehyde protein-binding form of AFB1 to the non-binding AFB1 dialcohol.
Pssm-ID: 381301 [Multi-domain] Cd Length: 304 Bit Score: 153.10 E-value: 2.08e-43
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490304600 81 LGCLPMvGYYGG--GPRDRKAMVSLIRAAfeqGITFFDTAEVYGPHLSEEFVGEALAPVRdRVVIATKFGFGVeegkPTS 158
Cdd:cd19075 5 LGTMTF-GSQGRftTAEAAAELLDAFLER---GHTEIDTARVYPDGTSEELLGELGLGER-GFKIDTKANPGV----GGG 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490304600 159 LNshPDHIRRAVEGSLKRLKTDHIDLLYQHRPDPNVPIEDVAETVKALILEGKVKHWGLSEASARTIRRAHA-------V 231
Cdd:cd19075 76 LS--PENVRKQLETSLKRLKVDKVDVFYLHAPDRSTPLEETLAAIDELYKEGKFKEFGLSNYSAWEVAEIVEickengwV 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490304600 232 LPvTAVQSEYAMWWREPETRIFPTLEELGIGFVPYCPTARSFLAGavnpsqRFDSTDRRHNLPRFQPD-ALAKNM----- 305
Cdd:cd19075 154 LP-TVYQGMYNAITRQVETELFPCLRKLGIRFYAYSPLAGGFLTG------KYKYSEDKAGGGRFDPNnALGKLYrdryw 226
|
250 260 270
....*....|....*....|....*....|.
gi 490304600 306 --VLLEFAQSW---ARRKNTTPVQFALAWVM 331
Cdd:cd19075 227 kpSYFEALEKVeeaAEKEGISLAEAALRWLY 257
|
|
| AKR_unchar |
cd19752 |
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ... |
77-356 |
1.36e-42 |
|
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.
Pssm-ID: 381391 [Multi-domain] Cd Length: 291 Bit Score: 150.56 E-value: 1.36e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490304600 77 SSMGLGCLpmvgyYGGGPRDRKAMVSLIRAAFEQGITFFDTAEVYGPHL-------SEEFVGEALA--PVRDRVVIATKF 147
Cdd:cd19752 1 SELCLGTM-----YFGTRTDEETSFAILDRYVAAGGNFLDTANNYAFWTeggvggeSERLIGRWLKdrGNRDDVVIATKV 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490304600 148 GFGVEE--GKPTSLNS-HPDHIRRAVEGSLKRLKTDHIDLLYQHRPDPNVPIEDVAETVKALILEGKVKHWGLSE----- 219
Cdd:cd19752 76 GAGPRDpdGGPESPEGlSAETIEQEIDKSLRRLGTDYIDLYYAHVDDRDTPLEETLEAFNELVKAGKVRAIGASNfaawr 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490304600 220 -ASARTIRRAHAVLPVTAVQSEYAMWWREPETRI---FPTLEEL--------GIGFVPYCPTarsfLAGAvnpsqrFDST 287
Cdd:cd19752 156 lERARQIARQQGWAEFSAIQQRHSYLRPRPGADFgvqRIVTDELldyassrpDLTLLAYSPL----LSGA------YTRP 225
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 490304600 288 DRRHNLPRFQPDALAKNMVLLEFAQswarRKNTTPVQFALAWVMAQRPWIVPIPGTTQYPHLIENSGAP 356
Cdd:cd19752 226 DRPLPEQYDGPDSDARLAVLEEVAG----ELGATPNQVVLAWLLHRTPAIIPLLGASTVEQLEENLAAL 290
|
|
| AKR_AKR10A1_2 |
cd19082 |
AKR10A family of aldo-keto reductase (AKR); Streptomyces bluensis aldo-keto reductase (BlmT) ... |
103-352 |
5.88e-42 |
|
AKR10A family of aldo-keto reductase (AKR); Streptomyces bluensis aldo-keto reductase (BlmT) and Streptomyces glaucescens aldo-keto reductase (StrT) are founding members of aldo-keto reductase family 10 member A1 (AKR10A1) and A2 (AKR10A2). BlmT is bluensomycin aldo-keto reductase (AKR) and StrT is streptomycin AKR.
Pssm-ID: 381308 [Multi-domain] Cd Length: 291 Bit Score: 148.86 E-value: 5.88e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490304600 103 LIRAAFEQGITFFDTAEVYG----PHLSEEFVGEALA--PVRDRVVIATKFGFGVEEGKPTSlNSHPDHIRRAVEGSLKR 176
Cdd:cd19082 22 LLDAFVELGGNFIDTARVYGdwveRGASERVIGEWLKsrGNRDKVVIATKGGHPDLEDMSRS-RLSPEDIRADLEESLER 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490304600 177 LKTDHIDLLYQHRPDPNVPIEDVAETVKALILEGKVKHWGLSE------ASARTIRRAHAVLPVTAVQSEY-------AM 243
Cdd:cd19082 101 LGTDYIDLYFLHRDDPSVPVGEIVDTLNELVRAGKIRAFGASNwsteriAEANAYAKAHGLPGFAASSPQWslarpnePP 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490304600 244 W------WREPETRIFptLEELGIGFVPYCPTARSFLAGAVNPSQRFDSTDRR-----HNLPRfqpdalaknmvlLEFAQ 312
Cdd:cd19082 181 WpgptlvAMDEEMRAW--HEENQLPVFAYSSQARGFFSKRAAGGAEDDSELRRvyyseENFER------------LERAK 246
|
250 260 270 280
....*....|....*....|....*....|....*....|
gi 490304600 313 SWARRKNTTPVQFALAWVMAQRPWIVPIPGTTQYPHLIEN 352
Cdd:cd19082 247 ELAEEKGVSPTQIALAYVLNQPFPTVPIIGPRTPEQLRDS 286
|
|
| PRK10376 |
PRK10376 |
putative oxidoreductase; Provisional |
68-370 |
1.70e-41 |
|
putative oxidoreductase; Provisional
Pssm-ID: 236676 [Multi-domain] Cd Length: 290 Bit Score: 147.81 E-value: 1.70e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490304600 68 TRKLGSLEVSSMGLGCLPMVG-YYGGGPRDRKAMVSLIRAAFEQGITFFDTAEVYGPHLSEEFVGEALAPVRDRVVIATK 146
Cdd:PRK10376 9 TFTLGGRSVNRLGYGAMQLAGpGVFGPPKDRDAAIAVLREAVALGVNHIDTSDFYGPHVTNQLIREALHPYPDDLTIVTK 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490304600 147 FGF--GVEEGKPTSLNshPDHIRRAVEGSLKRLKTDHIDLLY------QHRPDPNvPIEDVAETVKALILEGKVKHWGLS 218
Cdd:PRK10376 89 VGArrGEDGSWLPAFS--PAELRRAVHDNLRNLGLDVLDVVNlrlmgdGHGPAEG-SIEEPLTVLAELQRQGLVRHIGLS 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490304600 219 EASARTIRRAHAVLPVTAVQSEYAMWWREPETRIfPTLEELGIGFVPYCPTarsflaGAVNPsqrfdstdrrhnlprFQP 298
Cdd:PRK10376 166 NVTPTQVAEARKIAEIVCVQNHYNLAHRADDALI-DALARDGIAYVPFFPL------GGFTP---------------LQS 223
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 490304600 299 DALAknmvllefaqSWARRKNTTPVQFALAWVMAQRPWIVPIPGTTQYPHLIENSGAPQVRLTDRELREIDA 370
Cdd:PRK10376 224 STLS----------DVAASLGATPMQVALAWLLQRSPNILLIPGTSSVAHLRENLAAAELVLSEEVLAELDG 285
|
|
| ARA1 |
COG0656 |
Aldo/keto reductase, related to diketogulonate reductase [Secondary metabolites biosynthesis, ... |
84-371 |
3.47e-41 |
|
Aldo/keto reductase, related to diketogulonate reductase [Secondary metabolites biosynthesis, transport and catabolism];
Pssm-ID: 440421 [Multi-domain] Cd Length: 259 Bit Score: 145.97 E-value: 3.47e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490304600 84 LPMVGY--YGGGPRDRKAMVsliRAAFEQGITFFDTAEVYGphlSEEFVGEALAPV---RDRVVIATKFgfgveegkpts 158
Cdd:COG0656 5 IPALGLgtWQLPGEEAAAAV---RTALEAGYRHIDTAAMYG---NEEGVGEAIAASgvpREELFVTTKV----------- 67
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490304600 159 LNSH--PDHIRRAVEGSLKRLKTDHIDLLYQHRPDPnvpiEDVAETVKALI-L--EGKVKHWGLSEASARTIRRAHAVLP 233
Cdd:COG0656 68 WNDNhgYDDTLAAFEESLERLGLDYLDLYLIHWPGP----GPYVETWRALEeLyeEGLIRAIGVSNFDPEHLEELLAETG 143
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490304600 234 VT--AVQSEYAMWWREPETRifPTLEELGIGFVPYCPTARSflagavnpsqrfdstdrrhnlprfqpdALAKNMVLLEFA 311
Cdd:COG0656 144 VKpaVNQVELHPYLQQRELL--AFCREHGIVVEAYSPLGRG---------------------------KLLDDPVLAEIA 194
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|
gi 490304600 312 QswarRKNTTPVQFALAWVMAQRpwIVPIPGTTQYPHLIENSGAPQVRLTDRELREIDAA 371
Cdd:COG0656 195 E----KHGKTPAQVVLRWHLQRG--VVVIPKSVTPERIRENLDAFDFELSDEDMAAIDAL 248
|
|
| AKR_PA4992-like |
cd19095 |
Pseudomona aeruginosa PA4992 and similar proteins; Pseudomona aeruginosa PA4992 is the ... |
80-355 |
3.50e-40 |
|
Pseudomona aeruginosa PA4992 and similar proteins; Pseudomona aeruginosa PA4992 is the prototype of this family. It is a putative aldo-keto reductase that catalyzes the reversible reduction of ketones to the respective alcohols using NAD(P)H as a hydride donor.
Pssm-ID: 381321 [Multi-domain] Cd Length: 253 Bit Score: 143.14 E-value: 3.50e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490304600 80 GLGCLpmvGYYGG-GPRDRKAMVSLIRAAFEQGITFFDTAEVYGphLSEEFVGEALAPV-RDRVVIATKFGFGVEEGKPT 157
Cdd:cd19095 4 GLGTS---GIGRVwGVPSEAEAARLLNTALDLGINLIDTAPAYG--RSEERLGRALAGLrRDDLFIATKVGTHGEGGRDR 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490304600 158 SLNShPDHIRRAVEGSLKRLKTDHIDLLYQHRPDPNVPIEDVAETVKALILEGKVKHWGLSeASARTIRRAHAVLPVTAV 237
Cdd:cd19095 79 KDFS-PAAIRASIERSLRRLGTDYIDLLQLHGPSDDELTGEVLETLEDLKAAGKVRYIGVS-GDGEELEAAIASGVFDVV 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490304600 238 QSEYAMWWREpETRIFPTLEELGIGFVpycptARSFLAGAVNPSQRFDSTDRRHNLPRFQPDALAKnmvllefAQSWArr 317
Cdd:cd19095 157 QLPYNVLDRE-EEELLPLAAEAGLGVI-----VNRPLANGRLRRRVRRRPLYADYARRPEFAAEIG-------GATWA-- 221
|
250 260 270
....*....|....*....|....*....|....*...
gi 490304600 318 knttpvQFALAWVMAQRPWIVPIPGTTQYPHLIENSGA 355
Cdd:cd19095 222 ------QAALRFVLSHPGVSSAIVGTTNPEHLEENLAA 253
|
|
| AKR_AKR9A1-2 |
cd19146 |
Aspergillus nidulans sterigmatocystin biosynthesis dehydrogenase StcV, Aspergillus flavus ... |
71-372 |
4.17e-40 |
|
Aspergillus nidulans sterigmatocystin biosynthesis dehydrogenase StcV, Aspergillus flavus norsolorinic acid reductase (NOR), and similar proteins; Aspergillus nidulans sterigmatocystin biosynthesis dehydrogenase StcV and Aspergillus flavus norsolorinic acid reductase (NOR), are founding members of aldo-keto reductase family 9 member A1-2 (AKR9A1-2), respectively. StcV may be involved in the dehydration of 5'-hydroxyaverantin to form averufin. NOR is involved in aflatoxin biosynthesis.
Pssm-ID: 381372 [Multi-domain] Cd Length: 326 Bit Score: 144.87 E-value: 4.17e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490304600 71 LGSLEVSSMGLGCLPMVGYYGG--GPRDRKAMVSLIRAAFEQGITFFDTAEVYGPHLSEEFVGEALAP--VRDRVVIATK 146
Cdd:cd19146 6 TAGVRVSPLCLGAMSFGEAWKSmmGECDKETAFKLLDAFYEQGGNFIDTANNYQGEESERWVGEWMASrgNRDEMVLATK 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490304600 147 FGFGVEEGKPTSLNS-----HPDHIRRAVEGSLKRLKTDHIDLLYQHRPDPNVPIEDVAETVKALILEGKVKHWGLSEAS 221
Cdd:cd19146 86 YTTGYRRGGPIKIKSnyqgnHAKSLRLSVEASLKKLQTSYIDILYVHWWDYTTSIPELMQSLNHLVAAGKVLYLGVSDTP 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490304600 222 ARTIR------RAHAVLPVTAVQSEYAMWWREPETRIFPTLEELGIGFVPYCPTARSFLAGAVNPSQRfdSTDRRHNLPR 295
Cdd:cd19146 166 AWVVSkanayaRAHGLTQFVVYQGHWSAAFRDFERDILPMCEAEGMALAPWGVLGQGQFRTEEEFKRR--GRSGRKGGPQ 243
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 490304600 296 FQPDALAkNMVLLEFAQswarRKNTTPVQFALAWVMAQRPWIVPIPGTTQYPHLIENSGAPQVRLTDRELREIDAAL 372
Cdd:cd19146 244 TEKERKV-SEKLEKVAE----EKGTAITSVALAYVMHKAPYVFPIVGGRKVEHLKGNIEALGISLSDEEIQEIEDAY 315
|
|
| AKR_AKR3F1 |
cd19137 |
Thermotoga maritime Tm1743 and similar proteins; Thermotoga maritime Tm1743 is a founding ... |
75-369 |
4.88e-39 |
|
Thermotoga maritime Tm1743 and similar proteins; Thermotoga maritime Tm1743 is a founding member of aldo-keto reductase family 3 member F1 (AKR3F1). It is a aldo/keto reductase family oxidoreductase.
Pssm-ID: 381363 [Multi-domain] Cd Length: 260 Bit Score: 140.40 E-value: 4.88e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490304600 75 EVSSMGLGCLPMVGY-YGGGPRDRKaMVSLIRAAFEQGITFFDTAEVYGPHLSEEFVGEALAPV-RDRVVIATKFgfgve 152
Cdd:cd19137 3 KIPALGLGTWGIGGFlTPDYSRDEE-MVELLKTAIELGYTHIDTAEMYGGGHTEELVGKAIKDFpREDLFIVTKV----- 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490304600 153 egKPTSLNShpDHIRRAVEGSLKRLKTDHIDLLYQHRPDPNVPIEDVAETVKALILEGKVKHWGLSEASARTIRRAHAVL 232
Cdd:cd19137 77 --WPTNLRY--DDLLRSLQNSLRRLDTDYIDLYLIHWPNPNIPLEETLSAMAEGVRQGLIRYIGVSNFNRRLLEEAISKS 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490304600 233 --PVTAVQSEYAMWWREPETR-IFPTLEELGIGFVPYCPTARSflagavnpsqrfdstdrrhnlprfqpdALAKNMVLLE 309
Cdd:cd19137 153 qtPIVCNQVKYNLEDRDPERDgLLEYCQKNGITVVAYSPLRRG---------------------------LEKTNRTLEE 205
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|
gi 490304600 310 FAQSWARrkntTPVQFALAWVMaQRPWIVPIPGTTQYPHLIENSGAPQVRLTDRELREID 369
Cdd:cd19137 206 IAKNYGK----TIAQIALAWLI-QKPNVVAIPKAGRVEHLKENLKATEIKLSEEEMKLLD 260
|
|
| AKR_AKR3F2_3 |
cd19073 |
Escherichia coli 2,5-diketo-D-gluconic acid reductase B (DkgB/YafB), Sinorhizobium meliloti ... |
84-369 |
2.59e-38 |
|
Escherichia coli 2,5-diketo-D-gluconic acid reductase B (DkgB/YafB), Sinorhizobium meliloti isatin reductase and similar proteins; Escherichia coli DkgB/YafB (EC 1.1.1.346), also called 2,5-didehydrogluconate reductase (2-dehydro-L-gulonate-forming), or 2,5-DKG reductase B, or 2,5-DKGR B, or 25DKGR-B, is a founding member of aldo-keto reductase family 3 member F2 (AKR3F2). It catalyzes the reduction of 2,5-diketo-D-gluconic acid (25DKG) to 2-keto-L-gulonic acid (2KLG). Sinorhizobium meliloti isatin reductase is a founding member of aldo-keto reductase family 3 member F3 (AKR3F3). It is a aldo/keto reductase family oxidoreductase.
Pssm-ID: 381299 [Multi-domain] Cd Length: 243 Bit Score: 137.79 E-value: 2.59e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490304600 84 LPMVGYYGGGPRDRKAmVSLIRAAFEQGITFFDTAEVYGphlSEEFVGEALAPV---RDRVVIATKfgfgVEEGkptslN 160
Cdd:cd19073 1 IPALGLGTWQLRGDDC-ANAVKEALELGYRHIDTAEIYN---NEAEVGEAIAESgvpREDLFITTK----VWRD-----H 67
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490304600 161 SHPDHIRRAVEGSLKRLKTDHIDLLYQHRPDPNVPIEDVAETVKALILEGKVKHWGLSEASARTIRRAHAV--LPVTAVQ 238
Cdd:cd19073 68 LRPEDLKKSVDRSLEKLGTDYVDLLLIHWPNPTVPLEETLGALKELKEAGKVKSIGVSNFTIELLEEALDIspLPIAVNQ 147
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490304600 239 SEYAMWWREPETRIFptLEELGIGFVPYCPTARsflaGAVnpsqrfdstdrrhnlprfqpdalAKNMVLLEFAQswarRK 318
Cdd:cd19073 148 VEFHPFLYQAELLEY--CRENDIVITAYSPLAR----GEV-----------------------LRDPVIQEIAE----KY 194
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|.
gi 490304600 319 NTTPVQFALAWVMAQRpwIVPIPGTTQYPHLIENSGAPQVRLTDRELREID 369
Cdd:cd19073 195 DKTPAQVALRWLVQKG--IVVIPKASSEDHLKENLAIFDWELTSEDVAKID 243
|
|
| AKR_unchar |
cd19105 |
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ... |
68-228 |
1.08e-35 |
|
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.
Pssm-ID: 381331 [Multi-domain] Cd Length: 250 Bit Score: 131.17 E-value: 1.08e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490304600 68 TRKLG--SLEVSSMGLGClpmvgyyGGGPRDRkamVSLIRAAFEQGITFFDTAEVYGPHLSEEFVGEALA-PVRDRVVIA 144
Cdd:cd19105 3 YRTLGktGLKVSRLGFGG-------GGLPRES---PELLRRALDLGINYFDTAEGYGNGNSEEIIGEALKgLRRDKVFLA 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490304600 145 TKFGFGVEEGKptslnshPDHIRRAVEGSLKRLKTDHIDLLYQHRPDPNVPIEDVAETVKALI-L--EGKVKHWGLSEAS 221
Cdd:cd19105 73 TKASPRLDKKD-------KAELLKSVEESLKRLQTDYIDIYQLHGVDTPEERLLNEELLEALEkLkkEGKVRFIGFSTHD 145
|
....*....
gi 490304600 222 --ARTIRRA 228
Cdd:cd19105 146 nmAEVLQAA 154
|
|
| AKR_AKR14A2 |
cd19151 |
Salmonella enterica aldo-keto reductase (AKR) and similar protein; Salmonella enterica AKR is ... |
92-366 |
2.64e-35 |
|
Salmonella enterica aldo-keto reductase (AKR) and similar protein; Salmonella enterica AKR is a founding member of aldo-keto reductase family 14 member A2 (AKR14A2).
Pssm-ID: 381377 [Multi-domain] Cd Length: 309 Bit Score: 131.76 E-value: 2.64e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490304600 92 GGPRDRKAMVSLIRAAFEQGITFFDTAEVYGPHL--SEEFVG----EALAPVRDRVVIATKFGFGVEEGKPTSLNSHpDH 165
Cdd:cd19151 24 GDVDRYENSRAMLRRAFDLGITHFDLANNYGPPPgsAEENFGrilkEDLKPYRDELIISTKAGYTMWPGPYGDWGSK-KY 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490304600 166 IRRAVEGSLKRLKTDHIDLLYQHRPDPNVPIEdvaETVKAL---ILEGKVKHWGLSEASARTIRRAHAVL-----PVTAV 237
Cdd:cd19151 103 LIASLDQSLKRMGLDYVDIFYHHRPDPETPLE---ETMGALdqiVRQGKALYVGISNYPPEEAREAAAILkdlgtPCLIH 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490304600 238 QSEYAMWWREPETRIFPTLEELGIGFVPYCPTARSFLA----GAVNPSQRFDSTDRRHNLPRFQPDALAKNMVLLEFAQs 313
Cdd:cd19151 180 QPKYSMFNRWVEEGLLDVLEEEGIGCIAFSPLAQGLLTdrylNGIPEDSRAAKGSSFLKPEQITEEKLAKVRRLNEIAQ- 258
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....
gi 490304600 314 warRKNTTPVQFALAWVMAQRPWIVPIPGTTQYPHLIENSGA-PQVRLTDRELR 366
Cdd:cd19151 259 ---ARGQKLAQMALAWVLRNKRVTSVLIGASKPSQIEDAVGAlDNREFSEEELA 309
|
|
| AKR_AKR1-5-like |
cd19071 |
AKR1/2/3/4/5 family of aldo-keto reductase (AKR) and similar proteins; Aldo-keto reductases ... |
84-369 |
7.65e-35 |
|
AKR1/2/3/4/5 family of aldo-keto reductase (AKR) and similar proteins; Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. The family includes AKR1A/B/C/D/E/G/I, AKR2A/B/C/D/E, AKR3A/B/C/D/E/G, AKR4A/B/C, AKR5A/B/C/D/E/F/G/H, and similar proteins.
Pssm-ID: 381297 [Multi-domain] Cd Length: 251 Bit Score: 128.75 E-value: 7.65e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490304600 84 LPMVGYyGGGPRDRKAMVSLIRAAFEQGITFFDTAEVYGphlSEEFVGEALA---PVRDRVVIATKFgfgveegkpTSLN 160
Cdd:cd19071 1 MPLIGL-GTYKLKPEETAEAVLAALEAGYRHIDTAAAYG---NEAEVGEAIResgVPREELFITTKL---------WPTD 67
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490304600 161 SHPDHIRRAVEGSLKRLKTDHIDLLYQHRPDPNVPI---EDVAETVKALI---LEGKVKHWGLSEASARTIRR--AHAVL 232
Cdd:cd19071 68 HGYERVREALEESLKDLGLDYLDLYLIHWPVPGKEGgskEARLETWRALEelvDEGLVRSIGVSNFNVEHLEEllAAARI 147
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490304600 233 PVTAVQSEYAMWWREPETRIFptLEELGIGFVPYCPtarsfLAGAVNPsqrfdstdrrhnlprfqpdaLAKNMVLLEFAQ 312
Cdd:cd19071 148 KPAVNQIELHPYLQQKELVEF--CKEHGIVVQAYSP-----LGRGRRP--------------------LLDDPVLKEIAK 200
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*..
gi 490304600 313 swarRKNTTPVQFALAWVMaQRPwIVPIPGTTQYPHLIENSGAPQVRLTDRELREID 369
Cdd:cd19071 201 ----KYGKTPAQVLLRWAL-QRG-VVVIPKSSNPERIKENLDVFDFELSEEDMAAID 251
|
|
| AKR_unchar |
cd19100 |
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ... |
68-264 |
1.96e-34 |
|
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.
Pssm-ID: 381326 [Multi-domain] Cd Length: 238 Bit Score: 127.21 E-value: 1.96e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490304600 68 TRKLGS--LEVSSMGLGCLPMvgyyggGPRDRKAMVSLIRAAFEQGITFFDTAEVYGPhlSEEFVGEALAPVRDRVVIAT 145
Cdd:cd19100 1 YRRLGRtgLKVSRLGFGGGPL------GRLSQEEAAAIIRRALDLGINYFDTAPSYGD--SEEKIGKALKGRRDKVFLAT 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490304600 146 KFGfgveegkptslNSHPDHIRRAVEGSLKRLKTDHIDLLYQH----RPDPNVPIED--VAETVKALILEGKVKHWGLS- 218
Cdd:cd19100 73 KTG-----------ARDYEGAKRDLERSLKRLGTDYIDLYQLHavdtEEDLDQVFGPggALEALLEAKEEGKIRFIGISg 141
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|..
gi 490304600 219 ---EASARTIRRAH--AVL-PVTAVQSEYamwwREPETRIFPTLEELGIGFV 264
Cdd:cd19100 142 hspEVLLRALETGEfdVVLfPINPAGDHI----DSFREELLPLAREKGVGVI 189
|
|
| AKR_AKR3F3 |
cd19140 |
Sinorhizobium meliloti isatin reductase and similar proteins; Sinorhizobium meliloti isatin ... |
79-370 |
1.36e-33 |
|
Sinorhizobium meliloti isatin reductase and similar proteins; Sinorhizobium meliloti isatin reductase is a founding member of aldo-keto reductase family 3 member F3 (AKR3F3). It is a aldo/keto reductase family oxidoreductase.
Pssm-ID: 381366 [Multi-domain] Cd Length: 253 Bit Score: 125.45 E-value: 1.36e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490304600 79 MGLGCLPMVGyygggprdrKAMVSLIRAAFEQGITFFDTAEVYGphlSEEFVGEALA--PV-RDRVVIATKFGFgveegk 155
Cdd:cd19140 11 LGLGTYPLTG---------EECTRAVEHALELGYRHIDTAQMYG---NEAQVGEAIAasGVpRDELFLTTKVWP------ 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490304600 156 ptsLNSHPDHIRRAVEGSLKRLKTDHIDLLYQHRPDPNVPIEDVAETVKALILEGKVKHWGLSEASARTIRRA--HAVLP 233
Cdd:cd19140 73 ---DNYSPDDFLASVEESLRKLRTDYVDLLLLHWPNKDVPLAETLGALNEAQEAGLARHIGVSNFTVALLREAveLSEAP 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490304600 234 VTAVQSEYamwwrEP---ETRIFPTLEELGIGFVPYCPTARsflaGAVnpsqrfdstdrrhnlprfqpdalAKNMVLLEF 310
Cdd:cd19140 150 LFTNQVEY-----HPyldQRKLLDAAREHGIALTAYSPLAR----GEV-----------------------LKDPVLQEI 197
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|
gi 490304600 311 aqswARRKNTTPVQFALAWVMaQRPWIVPIPGTTQYPHLIENSGAPQVRLTDRELREIDA 370
Cdd:cd19140 198 ----GRKHGKTPAQVALRWLL-QQEGVAAIPKATNPERLEENLDIFDFTLSDEEMARIAA 252
|
|
| AKR_unchar |
cd19104 |
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ... |
68-279 |
2.55e-33 |
|
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.
Pssm-ID: 381330 [Multi-domain] Cd Length: 321 Bit Score: 126.61 E-value: 2.55e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490304600 68 TRKLG--SLEVSSMGLGClpmvGYYGG--GPRDRKAMVSLIRAAFEQGITFFDTAEVYGPHLSEEFVGEALAPVRDRVVI 143
Cdd:cd19104 2 YRRFGrtGLKVSELTFGG----GGIGGlmGRTTREEQIAAVRRALDLGINFFDTAPSYGDGKSEENLGRALKGLPAGPYI 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490304600 144 ATKFGFGveegkPTSLNSHPDHIRRAVEGSLKRLKTDHIDLLYQH---------RPDPNVPIED------VAETVKALIL 208
Cdd:cd19104 78 TTKVRLD-----PDDLGDIGGQIERSVEKSLKRLKRDSVDLLQLHnrigderdkPVGGTLSTTDvlglggVADAFERLRS 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490304600 209 EGKVKHWGLSEAS-ARTIRRAHAVLPVTAVQSEY------------AMWWREPETRIFPTLEELGIGFVPYCPTARSFLA 275
Cdd:cd19104 153 EGKIRFIGITGLGnPPAIRELLDSGKFDAVQVYYnllnpsaaearpRGWSAQDYGGIIDAAAEHGVGVMGIRVLAAGALT 232
|
....
gi 490304600 276 GAVN 279
Cdd:cd19104 233 TSLD 236
|
|
| COG1453 |
COG1453 |
Predicted oxidoreductase of the aldo/keto reductase family [General function prediction only]; |
68-371 |
1.81e-31 |
|
Predicted oxidoreductase of the aldo/keto reductase family [General function prediction only];
Pssm-ID: 441062 [Multi-domain] Cd Length: 365 Bit Score: 122.62 E-value: 1.81e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490304600 68 TRKLGS--LEVSSMGLGCLPMvgyygggPR-DRKAMVSLIRAAFEQGITFFDTAEVYgpHLSEEFVGEALAPVRDRVVIA 144
Cdd:COG1453 3 YRRLGKtgLEVSVLGFGGMRL-------PRkDEEEAEALIRRAIDNGINYIDTARGY--GDSEEFLGKALKGPRDKVILA 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490304600 145 TKFgfgveegkPTSLNShPDHIRRAVEGSLKRLKTDHIDLLYQHRPDPNVPIE------DVAETVKALILEGKVKHWGLS 218
Cdd:COG1453 74 TKL--------PPWVRD-PEDMRKDLEESLKRLQTDYIDLYLIHGLNTEEDLEkvlkpgGALEALEKAKAEGKIRHIGFS 144
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490304600 219 easartirrAHAVLPV--TAVQS---EYAM-------WWREPETRIFPTLEELGIGFV---PycptarsfLAGA--VNPS 281
Cdd:COG1453 145 ---------THGSLEVikEAIDTgdfDFVQlqynyldQDNQAGEEALEAAAEKGIGVIimkP--------LKGGrlANPP 207
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490304600 282 QRFdstdrrhnlprfqpdalaknMVLLEfaqswarrKNTTPVQFALAWVmAQRPWI-VPIPGTTQYPHLIEN--SGAPQV 358
Cdd:COG1453 208 EKL--------------------VELLC--------PPLSPAEWALRFL-LSHPEVtTVLSGMSTPEQLDENlkTADNLE 258
|
330
....*....|...
gi 490304600 359 RLTDRELREIDAA 371
Cdd:COG1453 259 PLTEEELAILERL 271
|
|
| AKR_AKR15A-like |
cd19090 |
AKR15A family of aldo-keto reductase and similar proteins; The AKR15 family includes ... |
77-276 |
2.52e-31 |
|
AKR15A family of aldo-keto reductase and similar proteins; The AKR15 family includes Microbacterium luteolum pyridoxal 4-dehydrogenase (PLD), Pseudomonas sp. D-threo-aldose 1-dehydrogenase (FDH) and similar proteins. PLD (EC1.1.1.107) catalyzes irreversible oxidation of pyridoxal. FDH (EC1.1.1.122), also called (2S,3R)-aldose dehydrogenase, or L-fucose dehydrogenase, catalyzes the oxidation of L-fucose to L-fuconolactone in the presence of NADP(+). It is also active against L-galactose and, to a much lesser degree, D-arabinose. FDH (EC1.1.1.122), also called (2S,3R)-aldose dehydrogenase, or L-fucose dehydrogenase, catalyzes the oxidation of L-fucose to L-fuconolactone in the presence of NADP(+). It is also active against L-galactose and, to a much lesser degree, D-arabinose. The family also includes L-galactose dehydrogenase (L-galDH) and D-arabinose 1-dehydrogenase (ARA2). L-galDH (EC 1.1.1.316), also called L-galactose 1-dehydrogenase, catalyzes the oxidation of L-galactose to L-galactono-1,4-lactone in the presence of NAD(+). It uses NAD(+) as a hydrogen acceptor much more efficiently than NADP(+). ARA2 (EC1.1.1.116), also called NAD(+)-specific D-arabinose dehydrogenase, catalyzes the the oxidation of D-arabinose to D-arabinono-1,4-lactone in the presence of NAD(+).
Pssm-ID: 381316 [Multi-domain] Cd Length: 278 Bit Score: 120.35 E-value: 2.52e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490304600 77 SSMGLGCLPMVGYYGGGPRDRKamVSLIRAAFEQGITFFDTAEVYGPhlSEEFVGEALA-PVRDRVVIATKFGFGVEEGK 155
Cdd:cd19090 1 SALGLGTAGLGGVFGGVDDDEA--VATIRAALDLGINYIDTAPAYGD--SEERLGLALAeLPREPLVLSTKVGRLPEDTA 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490304600 156 PTSlnshPDHIRRAVEGSLKRLKTDHIDLLYQHRPD--PNVPIEDVAETVKALIL---EGKVKHWGLS----EASARTIR 226
Cdd:cd19090 77 DYS----ADRVRRSVEESLERLGRDRIDLLMIHDPErvPWVDILAPGGALEALLElkeEGLIKHIGLGggppDLLRRAIE 152
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|..
gi 490304600 227 RAH--AVLPVtavqSEYAMWWREPETRIFPTLEELGIGFVPYCPTARSFLAG 276
Cdd:cd19090 153 TGDfdVVLTA----NRYTLLDQSAADELLPAAARHGVGVINASPLGMGLLAG 200
|
|
| AKR_KCAB3B_AKR6A9-like |
cd19160 |
voltage-gated potassium channel subunit beta-3 (KCAB3B) and similar proteins; KCAB3B from Homo ... |
69-376 |
3.58e-31 |
|
voltage-gated potassium channel subunit beta-3 (KCAB3B) and similar proteins; KCAB3B from Homo sapiens, Rattus norvegicus, and Mus musculus, are founding members of aldo-keto reductase family 6 member A9 (AKR6A9), A12 (AKR6A12), A14 (AKR6A14), respectively. KCAB3B, also called Shaker channel b-subunit 3 (Kvb3), K(+) channel subunit beta-3, or Kv-beta-3, is an accessory potassium channel protein which modulates the activity of the pore-forming alpha subunit. It alters the functional properties of Kv1.5.
Pssm-ID: 381386 [Multi-domain] Cd Length: 325 Bit Score: 120.86 E-value: 3.58e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490304600 69 RKLGS--LEVSSMGLGCLPMvgyYGGGPRDRKAMvSLIRAAFEQGITFFDTAEVYGPHLSEEFVGEALAPV---RDRVVI 143
Cdd:cd19160 6 RNLGKsgLRVSCLGLGTWVT---FGSQISDETAE-DLLTVAYEHGVNLFDTAEVYAAGKAERTLGNILKSKgwrRSSYVV 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490304600 144 ATKFGFGVEEGKPTSLNShpDHIRRAVEGSLKRLKTDHIDLLYQHRPDPNVPIEDVAETVKALILEGKVKHWGLSEASAR 223
Cdd:cd19160 82 TTKIYWGGQAETERGLSR--KHIIEGLRGSLDRLQLEYVDIVFANRSDPNSPMEEIVRAMTYVINQGMAMYWGTSRWSAM 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490304600 224 TIRRAHAV------LPVTAVQSEYAMWWREP-ETRIFPTLEELGIGFVPYCPTARSFLAGAVN---PSQRFDSTDRRHNL 293
Cdd:cd19160 160 EIMEAYSVarqfnlIPPVCEQAEYHLFQREKvEMQLPELYHKIGVGSVTWSPLACGLITGKYDgrvPDTCRAAVKGYQWL 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490304600 294 P-RFQPDALAKNMVLLEFAQSWARRKNTTPVQFALAWVMAQRPWIVPIPGTTQYPHLIENSGAPQV--RLTDRELREIDA 370
Cdd:cd19160 240 KeKVQSEEGKKQQAKVKELHPIADRLGCTVAQLAIAWCLRSEGVSSVLLGVSSAEQLIENLGSIQVlsQLTPQTVMEIDA 319
|
....*.
gi 490304600 371 ALAKIP 376
Cdd:cd19160 320 LLGNKP 325
|
|
| AKR_KCAB1B_AKR6A3-like |
cd19159 |
voltage-gated potassium channel subunit beta-1 (KCAB1B) and similar proteins; KCAB1B from Homo ... |
69-376 |
3.70e-31 |
|
voltage-gated potassium channel subunit beta-1 (KCAB1B) and similar proteins; KCAB1B from Homo sapiens, Mus musculus, Mustela putorius, Rattus norvegicus, and Kvb1.1, Kvb1.2 from Oryctolagus cuniculus, are founding members of aldo-keto reductase family 6 member A3 (AKR6A3), A8 (AKR6A8), A10a (AKR6A10a), A13 (AKR6A13), A7 (AKR6A7) and A10b (AKR6A10b), respectively. KCAB1B, also called Shaker channel b-subunit 1(Kvb1), K(+) channel subunit beta-1, or Kv-beta-1, is a cytoplasmic potassium channel subunit that modulates the characteristics of the channel-forming alpha-subunits. It modulates action potentials via its effect on the pore-forming alpha subunits.
Pssm-ID: 381385 [Multi-domain] Cd Length: 323 Bit Score: 120.92 E-value: 3.70e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490304600 69 RKLGS--LEVSSMGLGCLPMvgyYGGGPRDRKAMvSLIRAAFEQGITFFDTAEVYGPHLSEEFVGEALAPV---RDRVVI 143
Cdd:cd19159 4 RNLGKsgLRVSCLGLGTWVT---FGGQISDEVAE-RLMTIAYESGVNLFDTAEVYAAGKAEVILGSIIKKKgwrRSSLVI 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490304600 144 ATKFGFGVEEGKPTSLNSHpdHIRRAVEGSLKRLKTDHIDLLYQHRPDPNVPIEDVAETVKALILEGKVKHWGLSEASAR 223
Cdd:cd19159 80 TTKLYWGGKAETERGLSRK--HIIEGLKGSLQRLQLEYVDVVFANRPDSNTPMEEIVRAMTHVINQGMAMYWGTSRWSAM 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490304600 224 TIRRAHAV------LPVTAVQSEYAMWWREPETRIFPTL-EELGIGFVPYCPTARSFLAGAVNPSQRfDSTdrRHNLPRF 296
Cdd:cd19159 158 EIMEAYSVarqfnmIPPVCEQAEYHLFQREKVEVQLPELyHKIGVGAMTWSPLACGIISGKYGNGVP-ESS--RASLKCY 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490304600 297 QpdALAKNMVLLEFAQSWARRKNTTPV---------QFALAWVMAQRPWIVPIPGTTQYPHLIENSGAPQV--RLTDREL 365
Cdd:cd19159 235 Q--WLKERIVSEEGRKQQNKLKDLSPIaerlgctlpQLAVAWCLRNEGVSSVLLGSSTPEQLIENLGAIQVlpKMTSHVV 312
|
330
....*....|.
gi 490304600 366 REIDAALAKIP 376
Cdd:cd19159 313 NEIDNILRNKP 323
|
|
| AKR_AKR9A3_9B1-4 |
cd19147 |
Phanerochaete chrysosporium aryl-alcohol dehydrogenase [NADP(+)] (AAD) and similar proteins; ... |
70-369 |
9.95e-31 |
|
Phanerochaete chrysosporium aryl-alcohol dehydrogenase [NADP(+)] (AAD) and similar proteins; Phanerochaete chrysosporium ADD (EC1.1.1.91) is a founding member of aldo-keto reductase family 9 member A3. It is involved in lignin degradation and reduces aromatic benzaldehydes to their respective alcohols in the presence of NADP(H). This family also includes Saccharomyces cerevisiae aryl-alcohol dehydrogenases AAD14p, AAD3p, AAD4p, and AAD10p, which are founding members of aldo-keto reductase family 9 member B1-4 (AKR9B1-4), respectively.
Pssm-ID: 381373 [Multi-domain] Cd Length: 319 Bit Score: 119.54 E-value: 9.95e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490304600 70 KLGSLEVSSMGLGCLPMVGYYGG--GPRDRKAMVSLIRAAFEQGITFFDTAEVYGPHLSEEFVGE--ALAPVRDRVVIAT 145
Cdd:cd19147 4 KTAGIRVSPLILGAMSIGDAWSGfmGSMDKEQAFELLDAFYEAGGNFIDTANNYQDEQSETWIGEwmKSRKNRDQIVIAT 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490304600 146 KFGF---GVEEGKPTSLNSHPDHIRR---AVEGSLKRLKTDHIDLLYQHRPDPNVPIEDVAETVKALILEGKVKHWGLSE 219
Cdd:cd19147 84 KFTTdykAYEVGKGKAVNYCGNHKRSlhvSVRDSLRKLQTDWIDILYVHWWDYTTSIEEVMDSLHILVQQGKVLYLGVSD 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490304600 220 ------ASARTIRRAHAVLPVTAVQSEYAMWWREPETRIFPTLEELGIGFVPY---------CPTARSFLAGAVNPSQRF 284
Cdd:cd19147 164 tpawvvSAANYYATAHGKTPFSVYQGRWNVLNRDFERDIIPMARHFGMALAPWdvlgggkfqSKKAVEERKKNGEGLRSF 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490304600 285 DSTDRRHNLPRFQPDALAKnmvllefaqsWARRKNTTPVQ-FALAWVMAQRPWIVPIPGTTQYPHLIENSGAPQVRLTDR 363
Cdd:cd19147 244 VGGTEQTPEEVKISEALEK----------VAEEHGTESVTaIALAYVRSKAPNVFPLVGGRKIEHLKDNIEALSIKLTPE 313
|
....*.
gi 490304600 364 ELREID 369
Cdd:cd19147 314 EIEYLE 319
|
|
| AKR_KCAB2B_AKR6A1-like |
cd19158 |
voltage-gated potassium channel subunit beta-2 (KCAB2B) and similar proteins; KCAB2B from Bos ... |
69-376 |
2.13e-30 |
|
voltage-gated potassium channel subunit beta-2 (KCAB2B) and similar proteins; KCAB2B from Bos taurus, Rattus norvegicus, Mus musculus, Homo sapiens, and Oryctolagus cuniculus, are founding members of aldo-keto reductase family 6 member A1 (AKR6A1), A2 (AKR6A2), A4 (AKR6A4), A5 (AKR6A5), and A6 (AKR6A6), respectively. KCAB2B, also called Shaker channel b-subunit 2 (Kvb2), or K(+) channel subunit beta-2, or Kv-beta-2, or Kvbeta2, is a cytoplasmic potassium channel subunit that modulates the characteristics of the channel-forming alpha-subunits. It may be involved in the regulation of nerve signaling, and prevents neuronal hyperexcitability.
Pssm-ID: 381384 [Multi-domain] Cd Length: 324 Bit Score: 119.03 E-value: 2.13e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490304600 69 RKLGS--LEVSSMGLGCLPMvgyYGGGPRDRKAMvSLIRAAFEQGITFFDTAEVYGPHLSEEFVGEALAPV---RDRVVI 143
Cdd:cd19158 4 RNLGKsgLRVSCLGLGTWVT---FGGQITDEMAE-HLMTLAYDNGINLFDTAEVYAAGKAEVVLGNIIKKKgwrRSSLVI 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490304600 144 ATKFGFGVEEGKPTSLNShpDHIRRAVEGSLKRLKTDHIDLLYQHRPDPNVPIEDVAETVKALILEGKVKHWGLSEASAR 223
Cdd:cd19158 80 TTKIFWGGKAETERGLSR--KHIIEGLKASLERLQLEYVDVVFANRPDPNTPMEETVRAMTHVINQGMAMYWGTSRWSSM 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490304600 224 TIRRAHAV------LPVTAVQSEYAMWWREPETRIFPTL-EELGIGFVPYCPTARSFLAGAVN----PSQRFDSTDRRHN 292
Cdd:cd19158 158 EIMEAYSVarqfnlIPPICEQAEYHMFQREKVEVQLPELfHKIGVGAMTWSPLACGIVSGKYDsgipPYSRASLKGYQWL 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490304600 293 LPRFQPDALAKNMVLLEFAQSWARRKNTTPVQFALAWVMAQRPWIVPIPGTTQYPHLIENSGAPQV--RLTDRELREIDA 370
Cdd:cd19158 238 KDKILSEEGRRQQAKLKELQAIAERLGCTLPQLAIAWCLRNEGVSSVLLGASNAEQLMENIGAIQVlpKLSSSIVHEIDS 317
|
....*.
gi 490304600 371 ALAKIP 376
Cdd:cd19158 318 ILGNKP 323
|
|
| Aldo_ket_red_shaker |
cd19141 |
Shaker potassium channel beta subunit (AKR6A) family of aldo-keto reductase (AKR); This family ... |
69-359 |
3.60e-30 |
|
Shaker potassium channel beta subunit (AKR6A) family of aldo-keto reductase (AKR); This family includes voltage-gated potassium channel subunits, beta-1 (KCAB1B), beta-2 (KCAB2B) and beta-3 (KCAB3B). KCAB1B and KCAB2B are cytoplasmic potassium channel subunits that modulate the characteristics of the channel-forming alpha-subunits. KCAB3B is an accessory potassium channel protein which modulates the activity of the pore-forming alpha subunit.
Pssm-ID: 381367 [Multi-domain] Cd Length: 310 Bit Score: 117.93 E-value: 3.60e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490304600 69 RKLGS--LEVSSMGLGCLPMvgyYGGGPRDRKAMvSLIRAAFEQGITFFDTAEVYGPHLSEEFVGEALAPV---RDRVVI 143
Cdd:cd19141 3 RNLGKsgLRVSCLGLGTWVT---FGSQISDEVAE-ELVTLAYENGINLFDTAEVYAAGKAEIVLGKILKKKgwrRSSYVI 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490304600 144 ATKFGFGveeGKP-TSLNSHPDHIRRAVEGSLKRLKTDHIDLLYQHRPDPNVPIEDVAETVKALILEGKVKHWGLSEASA 222
Cdd:cd19141 79 TTKIFWG---GKAeTERGLSRKHIIEGLKASLERLQLEYVDIVFANRPDPNTPMEEIVRAFTHVINQGMAMYWGTSRWSA 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490304600 223 RTIRRAHAV------LPVTAVQSEYAMWWREPETRIFPTL-EELGIGFVPYCPTARSFLAG----AVNPSQRFDSTDRRH 291
Cdd:cd19141 156 MEIMEAYSVarqfnlIPPIVEQAEYHLFQREKVEMQLPELfHKIGVGAMTWSPLACGILSGkyddGVPEYSRASLKGYQW 235
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 490304600 292 NLPRFQPDALAKNMVLLEFAQSWARRKNTTPVQFALAWVMAQRPWIVPIPGTTQYPHLIENSGAPQVR 359
Cdd:cd19141 236 LKEKILSEEGRRQQAKLKELQIIADRLGCTLPQLAIAWCLKNEGVSSVLLGASSTEQLYENLQAIQVL 303
|
|
| AKR_unchar |
cd19103 |
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ... |
106-371 |
8.76e-29 |
|
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.
Pssm-ID: 381329 [Multi-domain] Cd Length: 299 Bit Score: 113.97 E-value: 8.76e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490304600 106 AAFEQGITFFDTAEVYGPHLSEEFVGEALAPV-RDRVVIATKFgfgveegKPTSLNSHPDHIRRAVEGSLKRLKTDHIDL 184
Cdd:cd19103 40 KAMAAGLNLWDTAAVYGMGASEKILGEFLKRYpREDYIISTKF-------TPQIAGQSADPVADMLEGSLARLGTDYIDI 112
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490304600 185 LYQHRPDpnvpieDVAETVKALIL---EGKVKHWGLSEASARTIRRAHAVL-----PVTAVQSEYAMWWREPET-RIFPT 255
Cdd:cd19103 113 YWIHNPA------DVERWTPELIPllkSGKVKHVGVSNHNLAEIKRANEILakagvSLSAVQNHYSLLYRSSEEaGILDY 186
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490304600 256 LEELGIGFVPYCPTARSFLAGAvnpsqrfdsTDRRHNLPRFQPDALAKNMVLLEFA------QSWARRKNTTPVQFALAW 329
Cdd:cd19103 187 CKENGITFFAYMVLEQGALSGK---------YDTKHPLPEGSGRAETYNPLLPQLEeltavmAEIGAKHGASIAQVAIAW 257
|
250 260 270 280
....*....|....*....|....*....|....*....|..
gi 490304600 330 VMAQRpwIVPIPGTTQYPHLIENSGAPQVRLTDRELREIDAA 371
Cdd:cd19103 258 AIAKG--TTPIIGVTKPHHVEDAARAASITLTDDEIKELEQL 297
|
|
| AKR_unchar |
cd19101 |
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ... |
92-372 |
2.37e-28 |
|
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.
Pssm-ID: 381327 [Multi-domain] Cd Length: 304 Bit Score: 112.69 E-value: 2.37e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490304600 92 GGPRDRKAMVSLIRAAFEQGITFFDTAEVYGPhlSEEFVGEALAPVR------DRVVIATKFGFGVEEGKPTslnshPDH 165
Cdd:cd19101 17 GGIRDEDAAVRAMAAYVDAGLTTFDCADIYGP--AEELIGEFRKRLRrerdaaDDVQIHTKWVPDPGELTMT-----RAY 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490304600 166 IRRAVEGSLKRLKTDHIDLLYQHRPDPNVP-IEDVAETVKALILEGKVKHWGLSEASARTIRRA-HAVLPVTAVQSEYAM 243
Cdd:cd19101 90 VEAAIDRSLKRLGVDRLDLVQFHWWDYSDPgYLDAAKHLAELQEEGKIRHLGLTNFDTERLREIlDAGVPIVSNQVQYSL 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490304600 244 WWREPETRIFPTLEELGIGFVPYCPTARSFLagavnpSQRF----DSTDRRHNLPRfqpdaLAKNMVLLEFAQSW----- 314
Cdd:cd19101 170 LDRRPENGMAALCEDHGIKLLAYGTLAGGLL------SEKYlgvpEPTGPALETRS-----LQKYKLMIDEWGGWdlfqe 238
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 490304600 315 --------ARRKNTTPVQFALAWVMaQRPWIV-PIPGTTQYPHLIENSGAPQVRLTDRELREIDAAL 372
Cdd:cd19101 239 llrtlkaiADKHGVSIANVAVRWVL-DQPGVAgVIVGARNSEHIDDNVRAFSFRLDDEDRAAIDAVL 304
|
|
| PRK09912 |
PRK09912 |
L-glyceraldehyde 3-phosphate reductase; Provisional |
58-373 |
3.48e-28 |
|
L-glyceraldehyde 3-phosphate reductase; Provisional
Pssm-ID: 182140 [Multi-domain] Cd Length: 346 Bit Score: 113.16 E-value: 3.48e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490304600 58 AAPVRKETLTTRKLGS--LEVSSMGLGCLPMVGYYGGGPRDRkamvSLIRAAFEQGITFFDTAEVYGP--HLSEEFVG-- 131
Cdd:PRK09912 5 ANPERYGQMQYRYCGKsgLRLPALSLGLWHNFGHVNALESQR----AILRKAFDLGITHFDLANNYGPppGSAEENFGrl 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490304600 132 --EALAPVRDRVVIATKFGFGVEEGkPTSLNSHPDHIRRAVEGSLKRLKTDHIDLLYQHRPDPNVPIEDVAETVKALILE 209
Cdd:PRK09912 81 lrEDFAAYRDELIISTKAGYDMWPG-PYGSGGSRKYLLASLDQSLKRMGLEYVDIFYSHRVDENTPMEETASALAHAVQS 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490304600 210 GKVKHWGLSEAS-ARTIRRAHAV----LPVTAVQSEYAMW--WREpETRIFPTLEELGIGFVPYCPTARSFLAGA-VNPS 281
Cdd:PRK09912 160 GKALYVGISSYSpERTQKMVELLrewkIPLLIHQPSYNLLnrWVD-KSGLLDTLQNNGVGCIAFTPLAQGLLTGKyLNGI 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490304600 282 QRFDSTDRRHNLPR-FQPDALAK-NMVLLEFAQSWARRKNTTPVQFALAWVMAQRPWIVPIPGTTQYPHLIENSGA-PQV 358
Cdd:PRK09912 239 PQDSRMHREGNKVRgLTPKMLTEaNLNSLRLLNEMAQQRGQSMAQMALSWLLKDERVTSVLIGASRAEQLEENVQAlNNL 318
|
330
....*....|....*
gi 490304600 359 RLTDRELREIDAALA 373
Cdd:PRK09912 319 TFSTEELAQIDQHIA 333
|
|
| AKR_galDH |
cd19163 |
L-galactose dehydrogenase (L-galDH) and similar proteins; L-galDH (EC 1.1.1.316), also called ... |
69-218 |
6.70e-28 |
|
L-galactose dehydrogenase (L-galDH) and similar proteins; L-galDH (EC 1.1.1.316), also called L-galactose 1-dehydrogenase, catalyzes the oxidation of L-galactose to L-galactono-1,4-lactone in the presence of NAD(+). It uses NAD(+) as a hydrogen acceptor much more efficiently than NADP(+).
Pssm-ID: 381389 [Multi-domain] Cd Length: 293 Bit Score: 111.10 E-value: 6.70e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490304600 69 RKLGS--LEVSSMGLGCLPMVGYYGggPRDRKAMVSLIRAAFEQGITFFDTAEVYGPHLSEEFVGEALAPV-RDRVVIAT 145
Cdd:cd19163 4 RKLGKtgLKVSKLGFGASPLGGVFG--PVDEEEAIRTVHEALDSGINYIDTAPWYGQGRSETVLGKALKGIpRDSYYLAT 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490304600 146 KFG-FGVEEgkPTSLNSHPDHIRRAVEGSLKRLKTDHIDLLYQHrpDPN-VPIED--VAETVKAL---ILEGKVKHWGLS 218
Cdd:cd19163 82 KVGrYGLDP--DKMFDFSAERITKSVEESLKRLGLDYIDIIQVH--DIEfAPSLDqiLNETLPALqklKEEGKVRFIGIT 157
|
|
| AKR_AKR6B1 |
cd19142 |
AKR6B family of aldo-keto reductase (AKR); Drosophila melanogaster Hk protein is a founding ... |
69-376 |
1.13e-25 |
|
AKR6B family of aldo-keto reductase (AKR); Drosophila melanogaster Hk protein is a founding member of aldo-keto reductase family 6 member B1 (AKR6B1). Hk protein, also called hyperkinetic, is a beta subunit of Shaker (Sh) K+ channels and shows high sequence homology to aldoketoreductase.
Pssm-ID: 381368 [Multi-domain] Cd Length: 325 Bit Score: 106.01 E-value: 1.13e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490304600 69 RKLGS--LEVSSMGLGCLPMVGYygggPRDRKAMVSLIRAAFEQGITFFDTAEVYGPHLSEEFVGEAL---APVRDRVVI 143
Cdd:cd19142 4 RNLGKsgLRVSNVGLGTWSTFST----AISEEQAEEIVTLAYENGINYFDTSDAFTSGQAETELGRILkkkGWKRSSYIV 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490304600 144 ATK-FGFGVEEGKPTSLNshpdHIRRAVEGSLKRLKTDHIDLLYQHRPDPNVPIEDVAETVKALILEGKVKHWGLSEAS- 221
Cdd:cd19142 80 STKiYWSYGSEERGLSRK----HIIESVRASLRRLQLDYIDIVIIHKADPMCPMEEVVRAMSYLIDNGLIMYWGTSRWSp 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490304600 222 -----ARTIRRAHAVLPVTAVQSEYAMWWREPETRIFPTL-EELGIGFVPYCPTARSFLAGaVNPSQRFDSTDRRHNLPR 295
Cdd:cd19142 156 veimeAFSIARQFNCPTPICEQSEYHMFCREKMELYMPELyNKVGVGLITWSPLSLGLDPG-ISEETRRLVTKLSFKSSK 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490304600 296 FQPDALAKNMVLLEFAQS--------WARRKNTTPVQFALAWVMAQRPWIVPIPGTTQYPHLIENSGAPQV--RLTDREL 365
Cdd:cd19142 235 YKVGSDGNGIHEETRRAShklrelslIAERLGCDLTQLLIAWSLKNENVQCVLIGASSLEQLYSQLNSLQLlpKLNSAVM 314
|
330
....*....|.
gi 490304600 366 REIDAALAKIP 376
Cdd:cd19142 315 EELERILDNKP 325
|
|
| AKR_AKR14A1 |
cd19150 |
Escherichia coli L-glyceraldehyde 3-phosphate reductase (GPR/YghZ/AKR14A1) and similar ... |
103-365 |
2.23e-25 |
|
Escherichia coli L-glyceraldehyde 3-phosphate reductase (GPR/YghZ/AKR14A1) and similar proteins; Escherichia coli L-glyceraldehyde 3-phosphate reductase (GPR/YghZ), also called GAP reductase, is a founding member of aldo-keto reductase family 14 member A1 (AKR14A1). It catalyzes the stereospecific, NADPH-dependent reduction of L-glyceraldehyde 3-phosphate (L-GAP). It is also involved in the stress response as a methylglyoxal reductase which converts the toxic metabolite methylglyoxal to acetol in vitro and in vivo.
Pssm-ID: 381376 [Multi-domain] Cd Length: 309 Bit Score: 104.84 E-value: 2.23e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490304600 103 LIRAAFEQGITFFDTAEVYGPHL--SEEFVGEAL----APVRDRVVIATKFGFGVEEGKPTSLNSHpDHIRRAVEGSLKR 176
Cdd:cd19150 35 ILRTAFDLGITHFDLANNYGPPPgsAEENFGRILredfAGYRDELIISTKAGYDMWPGPYGEWGSR-KYLLASLDQSLKR 113
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490304600 177 LKTDHIDLLYQHRPDPNVPIEDVAETVKALILEGKVKHWGLSEASARTIRRAHAVL-----PVTAVQSEYAMW--WREpE 249
Cdd:cd19150 114 MGLDYVDIFYSHRFDPDTPLEETMGALDHAVRSGKALYVGISSYSPERTREAAAILrelgtPLLIHQPSYNMLnrWVE-E 192
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490304600 250 TRIFPTLEELGIGFVPYCPTARSFLAGAVNPSQRFDStdRRHNLPRFQPDAL-AKNMVLLEFAQSWARRKNTTPVQFALA 328
Cdd:cd19150 193 SGLLDTLQELGVGCIAFTPLAQGLLTDKYLNGIPEGS--RASKERSLSPKMLtEANLNSIRALNEIAQKRGQSLAQMALA 270
|
250 260 270
....*....|....*....|....*....|....*...
gi 490304600 329 WVMAQRPWIVPIPGTTQYPHLIENSGA-PQVRLTDREL 365
Cdd:cd19150 271 WVLRDGRVTSALIGASRPEQLEENVGAlDNLTFSADEL 308
|
|
| AKR_Fe-S_oxidoreductase |
cd19096 |
Fe-S oxidoreductase and similar proteins; The family includes a group of uncharacterized Fe-S ... |
80-218 |
3.93e-25 |
|
Fe-S oxidoreductase and similar proteins; The family includes a group of uncharacterized Fe-S oxidoreductase that belongs to aldo-keto reductase (AKR) superfamily. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.
Pssm-ID: 381322 [Multi-domain] Cd Length: 255 Bit Score: 102.64 E-value: 3.93e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490304600 80 GLGC--LPMVGyygGGPRDRKAMVSLIRAAFEQGITFFDTAEVYGPHLSEEFVGEALAPV-RDRVVIATKFgfgveegkP 156
Cdd:cd19096 4 GFGTmrLPESD---DDSIDEEKAIEMIRYAIDAGINYFDTAYGYGGGKSEEILGEALKEGpREKFYLATKL--------P 72
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 490304600 157 TSLNSHPDHIRRAVEGSLKRLKTDHIDLLYQH---RPD--PNVPIEDVAETVKALILEGKVKHWGLS 218
Cdd:cd19096 73 PWSVKSAEDFRRILEESLKRLGVDYIDFYLLHglnSPEwlEKARKGGLLEFLEKAKKEGLIRHIGFS 139
|
|
| AKR_unchar |
cd19097 |
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ... |
96-337 |
4.67e-24 |
|
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.
Pssm-ID: 381323 [Multi-domain] Cd Length: 267 Bit Score: 99.91 E-value: 4.67e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490304600 96 DRKAMVSLIRAAFEQGITFFDTAEVYGphLSEEFVGEALAPvRDRVVIATKFGFGVEEGKptslnSHPDHIRRAVEGSLK 175
Cdd:cd19097 24 SEKEAKKILEYALKAGINTLDTAPAYG--DSEKVLGKFLKR-LDKFKIITKLPPLKEDKK-----EDEAAIEASVEASLK 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490304600 176 RLKTDHIDLLYQHRPDpNVPI--EDVAETVKALILEGKVKHWGLSEASARTIRRAHAVLPVTAVQSEYAMW-WREPETRI 252
Cdd:cd19097 96 RLKVDSLDGLLLHNPD-DLLKhgGKLVEALLELKKEGLIRKIGVSVYSPEELEKALESFKIDIIQLPFNILdQRFLKSGL 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490304600 253 FPTLEELGIGFVpycptARS-FLAGAVnpsqrFDSTDRRhnlprfqPDALAKNMVLLEFAQSWARRKNTTPVQFALAWVM 331
Cdd:cd19097 175 LAKLKKKGIEIH-----ARSvFLQGLL-----LMEPDKL-------PAKFAPAKPLLKKLHELAKKLGLSPLELALGFVL 237
|
....*.
gi 490304600 332 AQrPWI 337
Cdd:cd19097 238 SL-PEI 242
|
|
| AKR_unchar |
cd19099 |
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ... |
74-352 |
1.34e-23 |
|
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.
Pssm-ID: 381325 [Multi-domain] Cd Length: 316 Bit Score: 99.70 E-value: 1.34e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490304600 74 LEVSSMGLGClpmvgyYGGGPRD--RKAMVSLIRAAFEQGITFFDTAEVYGPHLSEEFVGEALAPV-------RDRVVIA 144
Cdd:cd19099 1 LTLSSLGLGT------YRGDSDDetDEEYREALKAALDSGINVIDTAINYRGGRSERLIGKALRELiekggikRDEVVIV 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490304600 145 TKFGF-------------GVEEGKPTSLNS-----------HPDHIRRAVEGSLKRLKTDHIDLLYQHRP-------DPN 193
Cdd:cd19099 75 TKAGYipgdgdeplrplkYLEEKLGRGLIDvadsaglrhciSPAYLEDQIERSLKRLGLDTIDLYLLHNPeeqllelGEE 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490304600 194 VPIEDVAETVKAL---ILEGKVKHWGLS--------EASARTI------RRAHAV-----------LPVTAVQSE-YAMW 244
Cdd:cd19099 155 EFYDRLEEAFEALeeaVAEGKIRYYGIStwdgfrapPALPGHLsleklvAAAEEVggdnhhfkviqLPLNLLEPEaLTEK 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490304600 245 WREPE--TRIFPTLEELGIGFVpycpTARSFLAGAVNPSQRFdstDRRHNLPRFQPDAlaknmvllefaqswarrknttp 322
Cdd:cd19099 235 NTVKGeaLSLLEAAKELGLGVI----ASRPLNQGQLLGELRL---ADLLALPGGATLA---------------------- 285
|
330 340 350
....*....|....*....|....*....|
gi 490304600 323 vQFALAWVMAQRPWIVPIPGTTQYPHLIEN 352
Cdd:cd19099 286 -QRALQFARSTPGVDSALVGMRRPEHVDEN 314
|
|
| AKR_FDH |
cd19162 |
D-threo-aldose 1-dehydrogenase (FDH) and similar proteins; FDH (EC1.1.1.122), also called (2S, ... |
77-286 |
9.04e-21 |
|
D-threo-aldose 1-dehydrogenase (FDH) and similar proteins; FDH (EC1.1.1.122), also called (2S,3R)-aldose dehydrogenase, or L-fucose dehydrogenase, catalyzes the oxidation of L-fucose to L-fuconolactone in the presence of NADP(+). It is also active against L-galactose, and to a much lesser degree, D-arabinose.
Pssm-ID: 381388 [Multi-domain] Cd Length: 290 Bit Score: 91.27 E-value: 9.04e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490304600 77 SSMGLGCLPMVGYYGGGPRDRKAMVSlirAAFEQGITFFDTAEVYGPHLSEEFVGEALAP-VRDRVVIATKFGFGVEEGK 155
Cdd:cd19162 1 PRLGLGAASLGNLARAGEDEAAATLD---AAWDAGIRYFDTAPLYGLGLSERRLGAALARhPRAEYVVSTKVGRLLEPGA 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490304600 156 PTSLNSHP-------DHIRRAVEGSLKRLKTDHIDLLYQHRPDP--NVPIEDVAETVKALILEGKVKHWGLSEASARTIR 226
Cdd:cd19162 78 AGRPAGADrrfdfsaDGIRRSIEASLERLGLDRLDLVFLHDPDRhlLQALTDAFPALEELRAEGVVGAIGVGVTDWAALL 157
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 490304600 227 RA--HAVLPVTAVQSEYAMWWREPETRIFPTLEELGIGFVPYCPTARSFLAGAVNPSQRFDS 286
Cdd:cd19162 158 RAarRADVDVVMVAGRYTLLDRRAATELLPLCAAKGVAVVAAGVFNSGILATDDPAGDRYDY 219
|
|
| AKR_galDH-like |
cd19153 |
L-galactose dehydrogenase (L-galDH), D-arabinose 1-dehydrogenase (ARA2) and similar proteins; ... |
68-239 |
2.03e-20 |
|
L-galactose dehydrogenase (L-galDH), D-arabinose 1-dehydrogenase (ARA2) and similar proteins; L-galDH (EC 1.1.1.316), also called L-galactose 1-dehydrogenase, catalyzes the oxidation of L-galactose to L-galactono-1,4-lactone in the presence of NAD(+). It uses NAD(+) as a hydrogen acceptor much more efficiently than NADP(+). ARA2 (EC1.1.1.116), also called NAD(+)-specific D-arabinose dehydrogenase, catalyzes the the oxidation of D-arabinose to D-arabinono-1,4-lactone in the presence of NAD(+).
Pssm-ID: 381379 [Multi-domain] Cd Length: 294 Bit Score: 90.67 E-value: 2.03e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490304600 68 TRKLGS--LEVSSMGLGCLPMVGYYGGGPRDRKAmVSLIRAAFEQGITFFDTAEVYGPHLSEEFVGEALAPV---RDRVV 142
Cdd:cd19153 2 GETLEIalGNVSPVGLGTAALGGVYGDGLEQDEA-VAIVAEAFAAGINHFDTSPYYGAESSEAVLGKALAALqvpRSSYT 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490304600 143 IATKFGFGVEEGKPTSlnshPDHIRRAVEGSLKRLKTDHIDLLYQHRPDPNVPIEDVAETVKALIL---EGKVKHWGLS- 218
Cdd:cd19153 81 VATKVGRYRDSEFDYS----AERVRASVATSLERLHTTYLDVVYLHDIEFVDYDTLVDEALPALRTlkdEGVIKRIGIAg 156
|
170 180
....*....|....*....|....
gi 490304600 219 ---EASARTIRRAhAVLPVTAVQS 239
Cdd:cd19153 157 yplDTLTRATRRC-SPGSLDAVLS 179
|
|
| AKR_ARA2 |
cd19164 |
D-arabinose 1-dehydrogenase (ARA2) and similar proteins; ARA2 (EC1.1.1.116), also called NAD(+) ... |
73-218 |
6.26e-20 |
|
D-arabinose 1-dehydrogenase (ARA2) and similar proteins; ARA2 (EC1.1.1.116), also called NAD(+)-specific D-arabinose dehydrogenase, catalyzes the the oxidation of D-arabinose to D-arabinono-1,4-lactone in the presence of NAD(+).
Pssm-ID: 381390 [Multi-domain] Cd Length: 298 Bit Score: 89.26 E-value: 6.26e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490304600 73 SLEVSSMGLGCLPMVGYYGGGPRDRKAmVSLIRAAFEQGITFFDTAEVYGPhlSEEFVGEALAPV-----RDRVVIATKF 147
Cdd:cd19164 10 LAGLPPLIFGAATFSYQYTTDPESIPP-VDIVRRALELGIRAFDTSPYYGP--SEIILGRALKALrdefpRDTYFIITKV 86
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 490304600 148 G-FGVEEgkptsLNSHPDHIRRAVEGSLKRLKTDHIDLLYQHrpDPN-VPIEDVAETVKALIL---EGKVKHWGLS 218
Cdd:cd19164 87 GrYGPDD-----FDYSPEWIRASVERSLRRLHTDYLDLVYLH--DVEfVADEEVLEALKELFKlkdEGKIRNVGIS 155
|
|
| AKR_AKR3F2 |
cd19139 |
Escherichia coli 2,5-diketo-D-gluconic acid reductase B (DkgB/YafB) and similar proteins; ... |
104-370 |
1.06e-19 |
|
Escherichia coli 2,5-diketo-D-gluconic acid reductase B (DkgB/YafB) and similar proteins; Escherichia coli DkgB/YafB (EC 1.1.1.346), also called 2,5-didehydrogluconate reductase (2-dehydro-L-gulonate-forming), or 2,5-DKG reductase B, or 2,5-DKGR B, or 25DKGR-B, is a founding member of aldo-keto reductase family 3 member F2 (AKR3F2). It catalyzes the reduction of 2,5-diketo-D-gluconic acid (25DKG) to 2-keto-L-gulonic acid (2KLG).
Pssm-ID: 381365 [Multi-domain] Cd Length: 248 Bit Score: 87.41 E-value: 1.06e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490304600 104 IRAAFEQGITFFDTAEVYGphlSEEFVGEALA--PV-RDRVVIATKFGFGveegkptslNSHPDHIRRAVEGSLKRLKTD 180
Cdd:cd19139 20 VRTALELGYRHIDTAQIYD---NEAAVGQAIAesGVpRDELFITTKIWID---------NLSKDKLLPSLEESLEKLRTD 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490304600 181 HIDLLYQHRPDPNVPIEdVAETVKALIL---EGKVKHWGLSEASARTIRRAHAVL---PVTAVQSEyamwwrepetrIFP 254
Cdd:cd19139 88 YVDLTLIHWPSPNDEVP-VEEYIGALAEakeQGLTRHIGVSNFTIALLDEAIAVVgagAIATNQIE-----------LSP 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490304600 255 TLEELGIgfVPYCptarsflagavnpsqrfdstdRRHNLP--RFQPdaLAKNMVL-LEFAQSWARRKNTTPVQFALAWVM 331
Cdd:cd19139 156 YLQNRKL--VAHC---------------------KQHGIHvtSYMT--LAYGKVLdDPVLAAIAERHGATPAQIALAWAM 210
|
250 260 270
....*....|....*....|....*....|....*....
gi 490304600 332 aQRPWIVpIPGTTQYPHLIENSGAPQVRLTDRELREIDA 370
Cdd:cd19139 211 -ARGYAV-IPSSTKREHLRSNLLALDLTLDADDMAAIAA 247
|
|
| AKR_AKR15A1 |
cd19161 |
Microbacterium luteolum pyridoxal 4-dehydrogenase (PLD) and similar proteins; Microbacterium ... |
77-288 |
4.64e-19 |
|
Microbacterium luteolum pyridoxal 4-dehydrogenase (PLD) and similar proteins; Microbacterium luteolum PLD (EC1.1.1.107) is a founding member of aldo-keto reductase family 15 member A1 (AKR15A1). It catalyzes irreversible oxidation of pyridoxal.
Pssm-ID: 381387 [Multi-domain] Cd Length: 310 Bit Score: 87.00 E-value: 4.64e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490304600 77 SSMGLGCLPMVGYYGggPRDRKAMVSLIRAAFEQGITFFDTAEVYGPHLSEEFVGEALAPV-RDRVVIATKFG---FGVE 152
Cdd:cd19161 1 SELGLGTAGLGNLYT--AVSNADADATLDAAWDSGIRYFDTAPMYGHGLAEHRLGDFLREKpRDEFVLSTKVGrllKPAR 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490304600 153 EG---------KPTSLNSHPDH----IRRAVEGSLKRLKTDHIDLLYQHRPDPnVPIEDVAETV----------KA---L 206
Cdd:cd19161 79 EGsvpdpngfvDPLPFEIVYDYsydgIMRSFEDSLQRLGLNRIDILYVHDIGV-YTHGDRKERHhfaqlmsggfKAleeL 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490304600 207 ILEGKVKHWGLSEASARTIRRA--HAVLPVTAVQSEYAMWWREPETRIFPTLEELGIGFVPYCPTARSFLAGAVNPSQRF 284
Cdd:cd19161 158 KKAGVIKAFGLGVNEVQICLEAldEADLDCFLLAGRYSLLDQSAEEEFLPRCEQRGTSLVIGGVFNSGILATGTKSGAKF 237
|
....
gi 490304600 285 DSTD 288
Cdd:cd19161 238 NYGD 241
|
|
| AKR_AKR3C2-3 |
cd19120 |
Saccharomyces pombe NAD/NADP-dependent indole-3-acetaldehyde reductase, Candida parapsilosis ... |
83-376 |
5.89e-19 |
|
Saccharomyces pombe NAD/NADP-dependent indole-3-acetaldehyde reductase, Candida parapsilosis NADPH-dependent conjugated polyketone reductase C2 (CPR), and similar proteins; Saccharomyces pombe NAD/NADP-dependent indole-3-acetaldehyde reductase (EC 1.1.1.190/EC 1.1.1.191) and Candida parapsilosis NADPH-dependent CPR (EC 1.1.1.358/EC 1.1.1.168) are founding members of aldo-keto reductase family 3 member C2 (AKR3C2) and C3 (AKR3C3), respectively. Saccharomyces pombe NAD/NADP-dependent indole-3-acetaldehyde reductase catalyzes the conversion from (Indol-3-yl)ethanol to (indol-3-yl)acetaldehyde in a NAD/NADP-dependent manner. CPR, also called 2-dehydropantolactone reductase, or 2-dehydropantolactone reductase (A-specific), or ketopantoyl-lactone reductase, acts as a NADPH-dependent conjugated polyketone reductase with broad substrate specificity and strict stereospecificity. It reduces ketopantoyl lactone and isatin.
Pssm-ID: 381346 [Multi-domain] Cd Length: 269 Bit Score: 85.75 E-value: 5.89e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490304600 83 CLPMVGY------YGGGPRDR-KAMVSLIRAAFEQGITFFDTAEVYGphlSEEFVGEALAPV---RDRVVIATKFGFGVe 152
Cdd:cd19120 3 KIPAIAFgtgtawYKSGDDDIqRDLVDSVKLALKAGFRHIDTAEMYG---NEKEVGEALKESgvpREDLFITTKVSPGI- 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490304600 153 egkptslnshpDHIRRAVEGSLKRLKTDHIDLLYQHRP----DPNVPIEDVAETVKALILEGKVKHWGLSEASARTIRR- 227
Cdd:cd19120 79 -----------KDPREALRKSLAKLGVDYVDLYLIHSPffakEGGPTLAEAWAELEALKDAGLVRSIGVSNFRIEDLEEl 147
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490304600 228 -AHAVLPVTAVQSEYamwwrepetriFPTLEELGIGFVPYCptarsflagavnpsqrfdstdRRHN-----------LPR 295
Cdd:cd19120 148 lDTAKIKPAVNQIEF-----------HPYLYPQQPALLEYC---------------------REHGivvsaysplspLTR 195
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490304600 296 FQPDALAKnmVLLEFAQswarRKNTTPVQFALAWVMAQRpwIVPIPGTTQYPHLIENSGAPQVRLTDRELREIDAALAKI 375
Cdd:cd19120 196 DAGGPLDP--VLEKIAE----KYGVTPAQVLLRWALQKG--IVVVTTSSKEERMKEYLEAFDFELTEEEVEEIDKAGKQK 267
|
.
gi 490304600 376 P 376
Cdd:cd19120 268 H 268
|
|
| PLN02587 |
PLN02587 |
L-galactose dehydrogenase |
69-218 |
3.52e-18 |
|
L-galactose dehydrogenase
Pssm-ID: 178198 [Multi-domain] Cd Length: 314 Bit Score: 84.44 E-value: 3.52e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490304600 69 RKLGS--LEVSSMGLGCLPMVGYYGGGPRDrkAMVSLIRAAFEQGITFFDTAEVYGPHLSEEFVGEAL--APV-RDRVVI 143
Cdd:PLN02587 2 RELGStgLKVSSVGFGASPLGSVFGPVSEE--DAIASVREAFRLGINFFDTSPYYGGTLSEKVLGKALkaLGIpREKYVV 79
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 490304600 144 ATKFGFGVEegkptSLNSHPDHIRRAVEGSLKRLKTDHIDLLYQHRPDPNVPIEDVAETVKALIL---EGKVKHWGLS 218
Cdd:PLN02587 80 STKCGRYGE-----GFDFSAERVTKSVDESLARLQLDYVDILHCHDIEFGSLDQIVNETIPALQKlkeSGKVRFIGIT 152
|
|
| AKR_AKR15A |
cd19152 |
AKR15A family of aldo-keto reductase; The AKR15 family includes Microbacterium luteolum ... |
79-276 |
6.95e-18 |
|
AKR15A family of aldo-keto reductase; The AKR15 family includes Microbacterium luteolum pyridoxal 4-dehydrogenase (PLD), Pseudomonas sp. D-threo-aldose 1-dehydrogenase (FDH), and similar proteins. PLD (EC1.1.1.107) catalyzes irreversible oxidation of pyridoxal. FDH(EC1.1.1.122), also called (2S,3R)-aldose dehydrogenase, or L-fucose dehydrogenase, catalyzes the oxidation of L-fucose to L-fuconolactone in the presence of NADP(+). It is also active against L-galactose, and to a much lesser degree, D-arabinose. FDH (EC1.1.1.122), also called (2S,3R)-aldose dehydrogenase, or L-fucose dehydrogenase, catalyzes the oxidation of L-fucose to L-fuconolactone in the presence of NADP(+). It is also active against L-galactose, and to a much lesser degree, D-arabinose.
Pssm-ID: 381378 [Multi-domain] Cd Length: 308 Bit Score: 83.43 E-value: 6.95e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490304600 79 MGLGCLPMVGYYGGGPRDRkaMVSLIRAAFEQGITFFDTAEVYGPHLSEEFVGEALAPV-RDRVVIATKFGF------GV 151
Cdd:cd19152 3 LGFGTAPLGNLYEAVSDEE--AKATLVAAWDLGIRYFDTAPWYGAGLSEERLGAALRELgREDYVISTKVGRllvplqEV 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490304600 152 EEGKPTSLNSHPDH----------IRRAVEGSLKRLKTDHIDLLYQHRPDPNVPI--------EDVAETVKALIL---EG 210
Cdd:cd19152 81 EPTFEPGFWNPLPFdavfdysydgILRSIEDSLQRLGLSRIDLLSIHDPDEDLAGaesdehfaQAIKGAFRALEElreEG 160
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 490304600 211 KVKHWGLSEASARTIRRA--HAVLPVTAVQSEYAMWWREPETRIFPTLEELGIGFVPYCPTARSFLAG 276
Cdd:cd19152 161 VIKAIGLGVNDWEVILRIleEADLDWVMLAGRYTLLDHSAARELLPECEKRGVKVVNAGPFNSGFLAG 228
|
|
| AKR_AKR1G1_CeAKR |
cd19154 |
Caenorhabditis elegans aldo-keto reductase (CeAKR) and similar proteins; CeAKR is a founding ... |
84-370 |
1.23e-16 |
|
Caenorhabditis elegans aldo-keto reductase (CeAKR) and similar proteins; CeAKR is a founding member of aldo-keto reductase family 1 member G1 (AKR1G1). It may catalyze the reversible reduction of ketones to the respective alcohols using NAD(P)H as a hydride donor.
Pssm-ID: 381380 [Multi-domain] Cd Length: 303 Bit Score: 79.76 E-value: 1.23e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490304600 84 LPMVGY--YGGGPRDrkaMVSLIRAAFEQGITFFDTAEVYGphlSEEFVGEALAPV-------RDRVVIATKFGFGVEEg 154
Cdd:cd19154 12 MPLIGLgtWQSKGAE---GITAVRTALKAGYRLIDTAFLYQ---NEEAIGEALAELleegvvkREDLFITTKLWTHEHA- 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490304600 155 kptslnshPDHIRRAVEGSLKRLKTDHIDLLYQHRP-------------------DPNVPIEDVAETVKALILEGKVKHW 215
Cdd:cd19154 85 --------PEDVEEALRESLKKLQLEYVDLYLIHAPaafkddegesgtmengmsiHDAVDVEDVWRGMEKVYDEGLTKAI 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490304600 216 GLSEASARTIRRAHAV--LPVTAVQSEYAMWWREPETRIFptLEELGIGFVPYCPTARsflAGAVNPsqrfDSTDRRHNL 293
Cdd:cd19154 157 GVSNFNNDQIQRILDNarVKPHNNQVECHLYFPQKELVEF--CKKHNISVTSYATLGS---PGRANF----TKSTGVSPA 227
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 490304600 294 PRFQPDALAKNMvllefaqswARRKNTTPVQFALAWVMaQRPWIVpIPGTTQYPHLIENSGAPQVRLTDRELREIDA 370
Cdd:cd19154 228 PNLLQDPIVKAI---------AEKHGKTPAQVLLRYLL-QRGIAV-IPKSATPSRIKENFNIFDFSLSEEDMATLEE 293
|
|
| tas |
PRK10625 |
putative aldo-keto reductase; Provisional |
73-371 |
2.16e-16 |
|
putative aldo-keto reductase; Provisional
Pssm-ID: 236727 [Multi-domain] Cd Length: 346 Bit Score: 79.51 E-value: 2.16e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490304600 73 SLEVSSMGLGCLPmvgyYGGGPRDRKAMVSLiRAAFEQGITFFDTAEVYG--PH-----LSEEFVGEALAPV--RDRVVI 143
Cdd:PRK10625 10 SLEVSTLGLGTMT----FGEQNSEADAHAQL-DYAVAQGINLIDVAEMYPvpPRpetqgLTETYIGNWLAKRgsREKLII 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490304600 144 ATKFGfGVEEGKPTSLNSHP----DHIRRAVEGSLKRLKTDHIDLLYQHRPD--------------PNVPIEDVAETVKA 205
Cdd:PRK10625 85 ASKVS-GPSRNNDKGIRPNQaldrKNIREALHDSLKRLQTDYLDLYQVHWPQrptncfgklgyswtDSAPAVSLLETLDA 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490304600 206 L---ILEGKVKHWGLSEASARTIRR------AHAVLPVTAVQSEYAMWWREPETRIFPTLEELGIGFVPYCPTARSFL-- 274
Cdd:PRK10625 164 LaeqQRAGKIRYIGVSNETAFGVMRylhlaeKHDLPRIVTIQNPYSLLNRSFEVGLAEVSQYEGVELLAYSCLAFGTLtg 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490304600 275 --------AGAVNP-SQRFDstdrRHNLPRFQpDALAKNMVLlefaqswARRKNTTPVQFALAWVmAQRPWIVP-IPGTT 344
Cdd:PRK10625 244 kylngakpAGARNTlFSRFT----RYSGEQTQ-KAVAAYVDI-------AKRHGLDPAQMALAFV-RRQPFVAStLLGAT 310
|
330 340
....*....|....*....|....*..
gi 490304600 345 QYPHLIENSGAPQVRLTDRELREIDAA 371
Cdd:PRK10625 311 TMEQLKTNIESLHLTLSEEVLAEIEAV 337
|
|
| AKR_CeZK1290-like |
cd19135 |
Caenorhabditis elegans ZK1290.5 and similar proteins; Caenorhabditis elegans ZK1290.5 is the ... |
74-370 |
3.38e-16 |
|
Caenorhabditis elegans ZK1290.5 and similar proteins; Caenorhabditis elegans ZK1290.5 is the prototype of this family. It is an uncharacterized aldo/keto reductase family oxidoreductase.
Pssm-ID: 381361 [Multi-domain] Cd Length: 265 Bit Score: 77.75 E-value: 3.38e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490304600 74 LEVSSMGLGCLPMVGYYgggprdRKAMVSLIRaafEQGITFFDTAEVYGphlSEEFVGEALAPV---RDRVVIATKFgFG 150
Cdd:cd19135 11 VEMPILGLGTSHSGGYS------HEAVVYALK---ECGYRHIDTAKRYG---CEELLGKAIKESgvpREDLFLTTKL-WP 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490304600 151 VEEGKPTSlnshpdhiRRAVEGSLKRLKTDHIDLLYQHRPDPNVPIEDV----AETVKALIL---EGKVKHWGLSEASA- 222
Cdd:cd19135 78 SDYGYEST--------KQAFEASLKRLGVDYLDLYLLHWPDCPSSGKNVketrAETWRALEElydEGLCRAIGVSNFLIe 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490304600 223 --RTIRRAHAVLPVtAVQSEYAMWWREPETRIFptLEELGIGFVPYCPtarsflagavnpsqrfdstdrrhnlprfqpda 300
Cdd:cd19135 150 hlEQLLEDCSVVPH-VNQVEFHPFQNPVELIEY--CRDNNIVFEGYCP-------------------------------- 194
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 490304600 301 LAKNMVLLEFA-QSWARRKNTTPVQFALAWVMAQRpwIVPIPGTTQYPHLIENSGAPQVRLTDRELREIDA 370
Cdd:cd19135 195 LAKGKALEEPTvTELAKKYQKTPAQILIRWSIQNG--VVTIPKSTKEERIKENCQVFDFSLSEEDMATLDS 263
|
|
| AKR_DrGR-like |
cd19136 |
Danio rerio glyoxal reductase-like (GR-like) protein and similar proteins; Danio rerio GR-like ... |
84-370 |
4.92e-15 |
|
Danio rerio glyoxal reductase-like (GR-like) protein and similar proteins; Danio rerio GR-like protein is the prototype of this family. It is an uncharacterized aldo/keto reductase family oxidoreductase similar to Bacillus subtilis glyoxal reductase (YvgN) that reduces glyoxal and methylglyoxal (2-oxopropanal).
Pssm-ID: 381362 [Multi-domain] Cd Length: 262 Bit Score: 74.21 E-value: 4.92e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490304600 84 LPMVGYyggGP---RDRKAMVSLIRAAFEQGITFFDTAEVYGphlSEEFVGEALAP-------VRDRVVIATKFG---FG 150
Cdd:cd19136 1 MPILGL---GTfrlRGEEEVRQAVDAALKAGYRLIDTASVYR---NEADIGKALRDllpkyglSREDIFITSKLApkdQG 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490304600 151 VEEGkptslnshpdhiRRAVEGSLKRLKTDHIDLLYQHRPDP-NVPIEDVA------ETVKAL---ILEGKVKHWGLSEA 220
Cdd:cd19136 75 YEKA------------RAACLGSLERLGTDYLDLYLIHWPGVqGLKPSDPRnaelrrESWRALedlYKEGKLRAIGVSNY 142
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490304600 221 SARTIR--RAHAVLPVTAVQSEYAMWWREPETRIFptLEELGIGFVPYCPTARSflagavnpsqrfdstdrrhnlprfqP 298
Cdd:cd19136 143 TVRHLEelLKYCEVPPAVNQVEFHPHLVQKELLKF--CKDHGIHLQAYSSLGSG-------------------------D 195
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 490304600 299 DALAKNMVLLEFAQSWARrkntTPVQFALAWVMAQRpwIVPIPGTTQYPHLIENSGAPQVRLTDRELREIDA 370
Cdd:cd19136 196 LRLLEDPTVLAIAKKYGR----TPAQVLLRWALQQG--IGVIPKSTNPERIAENIKVFDFELSEEDMAELNA 261
|
|
| AKR_AKR1G1_1I |
cd19111 |
Caenorhabditis elegans aldo-keto reductase (CeAKR), Coptotermes gestroi aldo-keto reductase ... |
104-369 |
1.10e-14 |
|
Caenorhabditis elegans aldo-keto reductase (CeAKR), Coptotermes gestroi aldo-keto reductase (CgAKR-1) and similar proteins; CeAKR is a founding member of aldo-keto reductase family 1 member G1 (AKR1G1). It may catalyze the reversible reduction of ketones to the respective alcohols using NAD(P)H as a hydride donor. Coptotermes gestroi aldo-keto reductase (CgAKR-1) is a founding member of aldo-keto reductase family 1 member I (AKR1I). It is a multipurpose enzyme with potential biotechnological applications.
Pssm-ID: 381337 [Multi-domain] Cd Length: 286 Bit Score: 73.69 E-value: 1.10e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490304600 104 IRAAFEQGITFFDTAEVYGphlSEEFVGEALAPV-------RDRVVIATKFgfgveegkPTSLNShPDHIRRAVEGSLKR 176
Cdd:cd19111 23 VDYALFVGYRHIDTALSYQ---NEKAIGEALKWWlkngklkREEVFITTKL--------PPVYLE-FKDTEKSLEKSLEN 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490304600 177 LKTDHIDLLYQHRPDPNV-------------PIEDVAETVKALILEGKVKHWGLSEASARTIRR--AHAVLPVTAVQSEY 241
Cdd:cd19111 91 LKLPYVDLYLIHHPCGFVnkkdkgerelassDVTSVWRAMEALVSEGKVKSIGLSNFNPRQINKilAYAKVKPSNLQLEC 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490304600 242 AMWWREPETRIFptLEELGIGFVPYCPTARSFLAGAVNPSQrfdstdrrhnlprfQPDALAKNMVLlefaqSWARRKNTT 321
Cdd:cd19111 171 HAYLQQRELRKF--CNKKNIVVTAYAPLGSPGRANQSLWPD--------------QPDLLEDPTVL-----AIAKELDKT 229
|
250 260 270 280
....*....|....*....|....*....|....*....|....*...
gi 490304600 322 PVQFALAWVMAQRpwIVPIPGTTQYPHLIENSGAPQVRLTDRELREID 369
Cdd:cd19111 230 PAQVLLRFVLQRG--TGVLPKSTNKERIEENFEVFDFELTEEHFKKLK 275
|
|
| AKR_AKR2E1-5 |
cd19116 |
AKR2E family of aldo-keto reductase (AKR); Bombyx mori 3-dehydroecdysone reductase is a ... |
83-370 |
4.51e-14 |
|
AKR2E family of aldo-keto reductase (AKR); Bombyx mori 3-dehydroecdysone reductase is a founding member of aldo-keto reductase family 2 member E4 (AKR2E4). It is a NADP-dependent oxidoreductase with high 3-dehydroecdysone reductase activity. It may play a role in the regulation of molting and has lower activity with phenylglyoxal and isatin (in vitro). This family also includes 3-dehydroecdysone 3b-reductase from Spodoptera littoralis and Trichoplusia ni, DL-glyceraldehyde reductase from Drosophila melanogaster, aldo-keto reductase from Bombyx mori, which correspond to aldo-keto reductase family 2 member E1, E2, E3 and E5 (AKR2E1/2/3/5), respectively.
Pssm-ID: 381342 [Multi-domain] Cd Length: 292 Bit Score: 71.93 E-value: 4.51e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490304600 83 CLPMVGYYGGGPRDRKAMVSLIRAAFEQGITFFDTAEVYGphlSEEFVGEALAPV-------RDRVVIATKFGfgveegk 155
Cdd:cd19116 10 EIPAIALGTWKLKDDEGVRQAVKHAIEAGYRHIDTAYLYG---NEAEVGEAIREKiaegvvkREDLFITTKLW------- 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490304600 156 ptslNSHPDH--IRRAVEGSLKRLKTDHIDLLYQHRP-------DPNVPIE------DVAETVKA---LILEGKVKHWGL 217
Cdd:cd19116 80 ----NSYHEReqVEPALRESLKRLGLDYVDLYLIHWPvafkennDSESNGDgslsdiDYLETWRGmedLVKLGLTRSIGV 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490304600 218 SEASARTIRR--AHAVLPVTAVQSEyamwwrepetrIFPTL---------EELGIGFVPYCPTARSFLAGAVNPSQRFDS 286
Cdd:cd19116 156 SNFNSEQINRllSNCNIKPAVNQIE-----------VHPTLtqeklvaycQSNGIVVMAYSPFGRLVPRGQTNPPPRLDD 224
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490304600 287 tdrrhnlprfqpdalaknmvllEFAQSWARRKNTTPVQFALAWVMaQRPwIVPIPGTTQYPHLIENSGAPQVRLTDRELR 366
Cdd:cd19116 225 ----------------------PTLVAIAKKYGKTTAQIVLRYLI-DRG-VVPIPKSSNKKRIKENIDIFDFQLTPEEVA 280
|
....
gi 490304600 367 EIDA 370
Cdd:cd19116 281 ALNS 284
|
|
| dkgB |
PRK11172 |
2,5-didehydrogluconate reductase DkgB; |
76-384 |
1.00e-13 |
|
2,5-didehydrogluconate reductase DkgB;
Pssm-ID: 183012 [Multi-domain] Cd Length: 267 Bit Score: 70.82 E-value: 1.00e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490304600 76 VSSMGLGCLPMVGyygggprdrKAMVSLIRAAFEQGITFFDTAEVYGphlSEEFVGEALAP---VRDRVVIATKFGfgVE 152
Cdd:PRK11172 3 IPAFGLGTFRLKD---------QVVIDSVKTALELGYRAIDTAQIYD---NEAAVGQAIAEsgvPRDELFITTKIW--ID 68
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490304600 153 egkptslNSHPDHIRRAVEGSLKRLKTDHIDLLYQHRPDPN--VPiedVAETVKALIlegKVKHWGLSEA---SARTI-- 225
Cdd:PRK11172 69 -------NLAKDKLIPSLKESLQKLRTDYVDLTLIHWPSPNdeVS---VEEFMQALL---EAKKQGLTREigiSNFTIal 135
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490304600 226 -RRAHAVLPVTAV---QSEYAMWWREPETRIFptLEELGIGFVPYCPTArsflAGAVnpsqrfdstdrrhnlprfqpdal 301
Cdd:PRK11172 136 mKQAIAAVGAENIatnQIELSPYLQNRKVVAF--AKEHGIHVTSYMTLA----YGKV----------------------- 186
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490304600 302 AKNMVLLEFAQswarRKNTTPVQFALAWVMaQRPWIVpIPGTTQYPHLIENSGAPQVRLTDRELREIdAALAKiplqGGR 381
Cdd:PRK11172 187 LKDPVIARIAA----KHNATPAQVILAWAM-QLGYSV-IPSSTKRENLASNLLAQDLQLDAEDMAAI-AALDR----NGR 255
|
....
gi 490304600 382 -ADP 384
Cdd:PRK11172 256 lVSP 259
|
|
| AKR_AKR5D1_E1 |
cd19132 |
AKR5D and AKR5E families of aldo-keto reductase (AKR); 2,5-diketo-D-gluconic acid reductase B ... |
80-370 |
3.50e-13 |
|
AKR5D and AKR5E families of aldo-keto reductase (AKR); 2,5-diketo-D-gluconic acid reductase B (DkgB) from Corynebacterium sp. and 2,5-diketo-D-gluconic acid reductase Zymomonas mobilis are founding members of aldo-keto reductase family 5 member D1 (AKR5D1) and E1 (AKR5E1), respectively. DkgB (EC 1.1.1.274), also called 2,5-didehydrogluconate reductase (2-dehydro-D-gluconate-forming), or 2,5-DKG reductase B, or 2,5-DKGR B, or 25DKGR-B, catalyzes the reduction of 2,5-diketo-D-gluconic acid (25DKG) to 2-keto-L-gulonic acid (2KLG).
Pssm-ID: 381358 [Multi-domain] Cd Length: 255 Bit Score: 68.84 E-value: 3.50e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490304600 80 GLGCLPMVGYYGggprdrkamVSLIRAAFEQGITFFDTAEVYGphlSEEFVGEALA----PvRDRVVIATKFGfGVEEGK 155
Cdd:cd19132 11 GFGTYPLKGDEG---------VEAVVAALQAGYRLLDTAFNYE---NEGAVGEAVRrsgvP-REELFVTTKLP-GRHHGY 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490304600 156 ptslnshpDHIRRAVEGSLKRLKTDHIDLLYQHRPDPNVpieDV-AETVKALI---LEGKVKHWGLS---EASARTIRRA 228
Cdd:cd19132 77 --------EEALRTIEESLYRLGLDYVDLYLIHWPNPSR---DLyVEAWQALIearEEGLVRSIGVSnflPEHLDRLIDE 145
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490304600 229 HAVLPVTAvQSEYAMWWREPETRIFptLEELGIGFVPYCPTARsflagavnpsqrfdstdrrhnlprfqPDALAKNMVLL 308
Cdd:cd19132 146 TGVTPAVN-QIELHPYFPQAEQRAY--HREHGIVTQSWSPLGR--------------------------GSGLLDEPVIK 196
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 490304600 309 EFAQswarRKNTTPVQFALAWvMAQRPwIVPIPGTTQYPHLIENSGAPQVRLTDRELREIDA 370
Cdd:cd19132 197 AIAE----KHGKTPAQVVLRW-HVQLG-VVPIPKSANPERQRENLAIFDFELSDEDMAAIAA 252
|
|
| AKR_BaDH-like |
cd19129 |
Bradyrhizobium diazoefficiens dehydrogenase (DH) and similar proteins; Bradyrhizobium ... |
80-334 |
2.32e-11 |
|
Bradyrhizobium diazoefficiens dehydrogenase (DH) and similar proteins; Bradyrhizobium diazoefficiens DH is the prototype of this family. It belongs to aldo/keto reductase family.
Pssm-ID: 381355 [Multi-domain] Cd Length: 295 Bit Score: 64.02 E-value: 2.32e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490304600 80 GLGCLPMVGYyGGGPRDRKAMVSLIRAAFEQGITFFDTAEVYgphLSEEFVGEALAPV-------RDRVVIATKFgfgve 152
Cdd:cd19129 2 GSGAIPALGF-GTLIPDPSATRNAVKAALEAGFRHFDCAERY---RNEAEVGEAMQEVfkagkirREDLFVTTKL----- 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490304600 153 egkpTSLNSHPDHIRRAVEGSLKRLKTDHIDLLYQHRP--------------------DPNVPIEDVAETVKALILEGKV 212
Cdd:cd19129 73 ----WNTNHRPERVKPAFEASLKRLQLDYLDLYLIHTPfafqpgdeqdprdangnviyDDGVTLLDTWRAMERLVDEGRC 148
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490304600 213 KHWGLSEAS---ARTIRRAHAVLPVtAVQSEYAMWWrePETRIFPTLEELGIGFVPYCPTArsflagavnpsqrfdstdr 289
Cdd:cd19129 149 KAIGLSDVSlekLREIFEAARIKPA-VVQVESHPYL--PEWELLDFCKNHGIVLQAFAPLG------------------- 206
|
250 260 270 280
....*....|....*....|....*....|....*....|....*
gi 490304600 290 rHNLprfQPDALAKNMVLlefaqSWARRKNTTPVQFALAWVMaQR 334
Cdd:cd19129 207 -HGM---EPKLLEDPVIT-----AIARRVNKTPAQVLLAWAI-QR 241
|
|
| AKR_AKR5C2 |
cd19131 |
Escherichia coli 2,5-diketo-D-gluconic acid reductase A (DkgA/YqhE) and similar proteins; ... |
101-218 |
2.71e-11 |
|
Escherichia coli 2,5-diketo-D-gluconic acid reductase A (DkgA/YqhE) and similar proteins; Escherichia coli DkgA/YqhE is a founding member of aldo-keto reductase family 5 member C2 (AKR5C2). DkgA/YqhE (EC 1.1.1.274), also called 2,5-DKG reductase A, or 2,5-DKGR A, or 25DKGR-A, or AKR5C, catalyzes the reduction of 2,5-diketo-D-gluconic acid (25DKG) to 2-keto-L-gulonic acid (2KLG). It is also capable of stereoselective -keto ester reductions on ethyl acetoacetate and other 2-substituted derivatives.
Pssm-ID: 381357 [Multi-domain] Cd Length: 256 Bit Score: 63.16 E-value: 2.71e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490304600 101 VSLIRAAFEQGITFFDTAEVYGphlSEEFVGEALAPV---RDRVVIATKFgfgveegkptsLNSHPDH--IRRAVEGSLK 175
Cdd:cd19131 26 ASAVREALEVGYRSIDTAAIYG---NEEGVGKAIRASgvpREELFITTKL-----------WNSDQGYdsTLRAFDESLR 91
|
90 100 110 120
....*....|....*....|....*....|....*....|....*..
gi 490304600 176 RLKTDHIDLLYQHRPdpnVPIED-VAETVKALI---LEGKVKHWGLS 218
Cdd:cd19131 92 KLGLDYVDLYLIHWP---VPAQDkYVETWKALIelkKEGRVKSIGVS 135
|
|
| AKR_AKR2B1-10 |
cd19113 |
AKR2B family of aldo-keto reductase (AKR); The AKR2B family of AKR includes NAD(P)H-dependent ... |
70-370 |
6.59e-11 |
|
AKR2B family of aldo-keto reductase (AKR); The AKR2B family of AKR includes NAD(P)H-dependent D-xylose reductase (XR) from Pichia stipites, Kluyveromyces lactis, Pachysolen tannophilus, Candida tropicalis, and Candida tenuis, Gre3p from Saccharomyces cerevisiae, XR from Candida tropicalis, Pichia guilliermondii, Debaryomyces hansenli, and Debaryomyces nepalensis, which correspond to aldo-keto reductase family 2 member B1-B10 (AKR2B1-10), respectively. XR (EC1.1.1.307) catalyzes the NAD(P)H dependent reduction of xylose to xylitol.
Pssm-ID: 381339 [Multi-domain] Cd Length: 310 Bit Score: 62.85 E-value: 6.59e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490304600 70 KLGS-LEVSSMGLGCLPMvgyygggprDRKAMVSLIRAAFEQGITFFDTAEVYGphlSEEFVGEALAPV-------RDRV 141
Cdd:cd19113 4 KLNSgYKMPSVGFGCWKL---------DNATAADQIYQAIKAGYRLFDGAEDYG---NEKEVGEGVNRAideglvkREEL 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490304600 142 VIATKFgfgveegkptsLNS--HPDHIRRAVEGSLKRLKTDHIDLLYQHRP--------------------DPNVPIEDV 199
Cdd:cd19113 72 FLTSKL-----------WNNfhDPKNVETALNKTLSDLKLDYVDLFLIHFPiafkfvpieekyppgfycgdGDNFVYEDV 140
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490304600 200 --AETVKA---LILEGKVKHWGLSEASARTIR---RAHAVLPVtAVQSEYAMWWREPetRIFPTLEELGIGFVPYCPTA- 270
Cdd:cd19113 141 piLDTWKAlekLVDAGKIKSIGVSNFPGALILdllRGATIKPA-VLQIEHHPYLQQP--KLIEYAQKAGITITAYSSFGp 217
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490304600 271 RSFLagavnpsqrfdstdrRHNLPRfqpdalAKNMVLL---EFAQSWARRKNTTPVQFALAWVmAQRPwIVPIPGTTQYP 347
Cdd:cd19113 218 QSFV---------------ELNQGR------ALNTPTLfehDTIKSIAAKHNKTPAQVLLRWA-TQRG-IAVIPKSNLPE 274
|
330 340
....*....|....*....|...
gi 490304600 348 HLIENSGAPQVRLTDRELREIDA 370
Cdd:cd19113 275 RLLQNLSVNDFDLTKEDFEEIAK 297
|
|
| AKR_AKR5F1 |
cd19133 |
the AKR5F family of aldo-keto reductase (AKR); Klebsiella sp. 2,5-diketo-D-gluconic acid ... |
107-370 |
8.64e-11 |
|
the AKR5F family of aldo-keto reductase (AKR); Klebsiella sp. 2,5-diketo-D-gluconic acid reductase (2,5-DKG reductase) is a founding member of aldo-keto reductase family 5 member F1 (AKR5F1). It catalyzes the reduction of 2,5-diketo-D-gluconic acid (25DKG) to 2-keto-L-gulonic acid (2KLG).
Pssm-ID: 381359 [Multi-domain] Cd Length: 255 Bit Score: 61.82 E-value: 8.64e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490304600 107 AFEQGITFFDTAEVYGphlSEEFVGEALAPV---RDRVVIATKFGFGveegkptslNSHPDHIRRAVEGSLKRLKTDHID 183
Cdd:cd19133 32 AIKAGYRLIDTAAAYG---NEEAVGRAIKKSgipREELFITTKLWIQ---------DAGYEKAKKAFERSLKRLGLDYLD 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490304600 184 LLYQHRpdpnvPIEDVAETVKA---LILEGKVKHWGLSEASARTIRR---AHAVLPvtAV-QSEYAMWWREPETRIFptL 256
Cdd:cd19133 100 LYLIHQ-----PFGDVYGAWRAmeeLYKEGKIRAIGVSNFYPDRLVDlilHNEVKP--AVnQIETHPFNQQIEAVEF--L 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490304600 257 EELGIGFVPYCPTARSflagavnpsqrfdstdrRHNlprfqpdaLAKNMVLLEFAQswarRKNTTPVQFALAWVMaQRPw 336
Cdd:cd19133 171 KKYGVQIEAWGPFAEG-----------------RNN--------LFENPVLTEIAE----KYGKSVAQVILRWLI-QRG- 219
|
250 260 270
....*....|....*....|....*....|....
gi 490304600 337 IVPIPGTTQYPHLIENSGAPQVRLTDRELREIDA 370
Cdd:cd19133 220 IVVIPKSVRPERIAENFDIFDFELSDEDMEAIAA 253
|
|
| AKR_unchar |
cd19098 |
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ... |
106-376 |
3.52e-10 |
|
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.
Pssm-ID: 381324 [Multi-domain] Cd Length: 318 Bit Score: 60.82 E-value: 3.52e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490304600 106 AAFEQGITFFDTAEVYGphLSEEFVG---EALAPVRDRVVIATKFGF----------GVEEGKPTSLnshpDHIRRAVEG 172
Cdd:cd19098 43 AAWAAGVRYFDAARSYG--RAEEFLGswlRSRNIAPDAVFVGSKWGYtytadwqvdaAVHEVKDHSL----ARLLKQWEE 116
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490304600 173 SLKRLKtDHIDlLYQ-HRPDPNVPIEDVAETVKALIlEGKVKHW--GLSEAS---ARTIRRAHAVLP-----VTAVQSEy 241
Cdd:cd19098 117 TRSLLG-KHLD-LYQiHSATLESGVLEDADVLAALA-ELKAEGVkiGLSLSGpqqAETLRRALEIEIdgarlFDSVQAT- 192
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490304600 242 amwWREPETRIFPTLEEL---GIGFVpycptARSFLA-GAVnpsqrfdstdrrhnLPRFQPDALAKNMVLLEFAqswARR 317
Cdd:cd19098 193 ---WNLLEQSAGEALEEAheaGMGVI-----VKEALAnGRL--------------TDRNPSPELAPLMAVLKAV---ADR 247
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|
gi 490304600 318 KNTTPVQFALAWVMAQrPWI-VPIPGTTQYPHLIENSGAPQVRLtDRELREIDAALAKIP 376
Cdd:cd19098 248 LGVTPDALALAAVLAQ-PFVdVVLSGAATPEQLRSNLRALDVSL-DLELLAALADLAEPP 305
|
|
| AKR_AKR3G1 |
cd19123 |
AKR3G family of aldo-keto reductase (AKR); Synechocystis sp. aldo/keto reductase slr0942 is a ... |
104-370 |
5.25e-10 |
|
AKR3G family of aldo-keto reductase (AKR); Synechocystis sp. aldo/keto reductase slr0942 is a founding member of aldo-keto reductase family 3 member G1 (AKR3G1). It is an aldo/keto reductase that catalyzes the NADPH-dependent reduction of aldehyde- and ketone-groups of different classes of carbonyl compounds to the corresponding alcohols.
Pssm-ID: 381349 [Multi-domain] Cd Length: 297 Bit Score: 60.12 E-value: 5.25e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490304600 104 IRAAFEQGITFFDTAEVYGphlSEEFVGEALAPV-------RDRVVIATKFGFgveegkptslNSH-PDHIRRAVEGSLK 175
Cdd:cd19123 31 VKQALEAGYRHIDCAAIYG---NEAEIGAALAEVfkegkvkREDLWITSKLWN----------NSHaPEDVLPALEKTLA 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490304600 176 RLKTDHIDLLYQHRP------------------DPNVPIEDVAETVKALILEGKVKHWGLSEASARTIRRAHA---VLPV 234
Cdd:cd19123 98 DLQLDYLDLYLMHWPvalkkgvgfpesgedllsLSPIPLEDTWRAMEELVDKGLCRHIGVSNFSVKKLEDLLAtarIKPA 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490304600 235 TAvQSEYAMWWREPETRIFptLEELGIGFVPYCPtarsflagavnpsqrFDSTDRRHNLPRFQPDALAKNMVLLEFAQsw 314
Cdd:cd19123 178 VN-QVELHPYLQQPELLAF--CRDNGIHLTAYSP---------------LGSGDRPAAMKAEGEPVLLEDPVINKIAE-- 237
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*.
gi 490304600 315 arRKNTTPVQFALAWVMaQRPWIVpIPGTTQYPHLIENSGAPQVRLTDRELREIDA 370
Cdd:cd19123 238 --KHGASPAQVLIAWAI-QRGTVV-IPKSVNPERIQQNLEAAEVELDASDMATIAA 289
|
|
| AKR_AKR5B1 |
cd19127 |
AKR5B family of aldo-keto reductase (AKR); Pseudomonas putida morphine 6-dehydrogenase (M6DH) ... |
101-370 |
2.31e-09 |
|
AKR5B family of aldo-keto reductase (AKR); Pseudomonas putida morphine 6-dehydrogenase (M6DH) is a founding member of the aldo-keto reductase family 5 member B1 (AKR5B1). M6DH (EC 1.1.1.218), also called naloxone reductase, oxidizes the C-6 hydroxy group of morphine and codeine.
Pssm-ID: 381353 [Multi-domain] Cd Length: 268 Bit Score: 57.80 E-value: 2.31e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490304600 101 VSLIRAAFEQGITFFDTAEVYGphlSEEFVGEAL---APVRDRVVIATKFgFGVEEGKptslnshpDHIRRAVEGSLKRL 177
Cdd:cd19127 25 ADAVATALADGYRLIDTAAAYG---NEREVGEGIrrsGVDRSDIFVTTKL-WISDYGY--------DKALRGFDASLRRL 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490304600 178 KTDHIDLLYQHRPDPNVpIEDVAETVKAL---ILEGKVKHWGLSEASARTIRR---AHAVLPvtAV-QSEYAMWWREPET 250
Cdd:cd19127 93 GLDYVDLYLLHWPVPND-FDRTIQAYKALeklLAEGRVRAIGVSNFTPEHLERlidATTVVP--AVnQVELHPYFSQKDL 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490304600 251 RIFPTleELGIGFVPYCPTarsflaGAVNPSQRFDSTDRRHNLprfqpdalaKNMVLLEFAQSWARrkntTPVQFALAWV 330
Cdd:cd19127 170 RAFHR--RLGIVTQAWSPI------GGVMRYGASGPTGPGDVL---------QDPTITGLAEKYGK----TPAQIVLRWH 228
|
250 260 270 280
....*....|....*....|....*....|....*....|
gi 490304600 331 MAQRpwIVPIPGTTQYPHLIENSGAPQVRLTDRELREIDA 370
Cdd:cd19127 229 LQNG--VSAIPKSVHPERIAENIDIFDFALSAEDMAAIDA 266
|
|
| AKR_AKR4A_4B |
cd19124 |
AKR4A and AKR4B families of aldo-keto reductase (AKR); The AKR4A family of AKR includes ... |
94-333 |
8.28e-09 |
|
AKR4A and AKR4B families of aldo-keto reductase (AKR); The AKR4A family of AKR includes Glycine max NAD(P)H-dependent 6'-deoxychalcone synthase (6DCS, EC 3.1.170), chalcone reductase (CHR, EC 2.3.1.74) from Medicago sativa, Glycyrrhiza echinate, and Glycyrrhiza glabra, which are founding members of aldo-keto reductase family 4 member A1 (AKR4A1), A2 (AKR4A2), A3 (AKR4A3), and A4 (AKR4A4), respectively. NAD(P)H-6DCS co-acts with chalcone synthase in formation of 4,2',4'-trihydroxychalcone, involved in the biosynthesis of glyceollin type phytoalexins. CHR, also called chalcone polyketide reductase, is a key enzyme of the flavonoid/isoflavonoid biosynthesis pathway. The AKR4B family of AKR includes Sesbania rostrate chalcone reductase (CHR, AKR4B1), Papaver somniferum codeinone reductase (COR, AKR4B2/ AKR4B3), Fragaria x ananassa D-galacturonate reductase (GalUR, AKR4B4), deoxymugineic acid synthase 1 (DMAS1) from Zea mays (AKR4B5), Oryza sativa (AKR4B6), Hordeum vulgare (AKR4B7), Triticum aestivum (AKR4B8), and Erythroxylum coca methylecgonone reductase (MecgoR, AKR4B10). CHR, also called chalcone polyketide reductase, is a key enzyme of the flavonoid/isoflavonoid biosynthesis pathway. NADPH-dependent COR and non-functional NADPH-dependent COR from Papaver somniferum are founding members of aldo-keto reductase family 4 member B2 (AKR4B2) and B3 (AKR4B3), respectively. NADPH-dependent COR (EC 1.1.1.247) reduces codeinone to codeine in the penultimate step in morphine biosynthesis. It can use morphinone, hydrocodone, and hydromorphone as substrates during reductive reaction with NADPH as cofactor, and morphine and dihydrocodeine as substrates during oxidative reaction with NADP as cofactor. GalUR (EC 1.1.1.365), also called aldo-keto reductase 2 (AKR2), is involved in ascorbic acid (vitamin C) biosynthesis by catalyzing the conversion from L-galactonate and NADP(+) to D-galacturonate and NADPH. DMAS1 (EC 1.1.1.285) catalyzes the reduction of a 3''-keto intermediate during the biosynthesis of 2'-deoxymugineic acid (DMA) from L-Met. It is involved in the formation of phytosiderophores (MAs) belonging to the mugineic acid family and required to acquire iron. MecgoR catalyzes the stereospecific reduction of methylecgonone to methylecgonine, the penultimate step in cocaine biosynthesis.
Pssm-ID: 381350 [Multi-domain] Cd Length: 281 Bit Score: 56.12 E-value: 8.28e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490304600 94 PRDRKAMVSLIRAAFEQGITFFDTAEVYGphlSEEFVGEALAPVRDRVVIATKFGFGVEEgKPTSLNSHPDHIRRAVEGS 173
Cdd:cd19124 16 PPSPEDIKAAVLEAIEVGYRHFDTAAAYG---TEEALGEALAEALRLGLVKSRDELFVTS-KLWCSDAHPDLVLPALKKS 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490304600 174 LKRLKTDHIDLLYQHRP---DP---NVPIEDvaETVKALILEG------KVKHWGLSEA------SARTIRR--AHAVLP 233
Cdd:cd19124 92 LRNLQLEYVDLYLIHWPvslKPgkfSFPIEE--EDFLPFDIKGvweameECQRLGLTKAigvsnfSCKKLQEllSFATIP 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490304600 234 VTAVQSEYAMWWREPETRIFptLEELGIGFVPYCPtarsfLAGAVNPsqrfdstdrrhnlprFQPDALAKNMVLLEFAQS 313
Cdd:cd19124 170 PAVNQVEMNPAWQQKKLREF--CKANGIHVTAYSP-----LGAPGTK---------------WGSNAVMESDVLKEIAAA 227
|
250 260
....*....|....*....|
gi 490304600 314 warrKNTTPVQFALAWVMAQ 333
Cdd:cd19124 228 ----KGKTVAQVSLRWVYEQ 243
|
|
| AKR_AKR2A1-2 |
cd19112 |
AKR2A family of aldo-keto reductase (AKR); The AKR2A family of AKR includes AKR2A1 ... |
84-370 |
8.33e-09 |
|
AKR2A family of aldo-keto reductase (AKR); The AKR2A family of AKR includes AKR2A1 (NADP-dependent D-sorbitol-6-phosphate dehydrogenase or NADP-S6PDH) from Malus domestica, and AKR2A2 (NADPH-dependent mannose-6-phosphate reductase or NADPH-M6PR) from Apium graveolens. NADP-S6PDH (EC 1.1.1.200), also called aldose-6-phosphate reductase [NADPH], synthesizes sorbitol-6-phosphate, a key intermediate in the synthesis of sorbitol which is a major photosynthetic product in many members of the Rosaceae family. NADPH-M6PR (EC 1.1.1.224), also called NADPH-dependent M6P reductase, is a key enzyme involved in mannitol biosynthesis.
Pssm-ID: 381338 [Multi-domain] Cd Length: 308 Bit Score: 56.34 E-value: 8.33e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490304600 84 LPMVGYyGGGPRDRKAMVSLIRAAFEQGITFFDTAEVYGphlSEEFVGEALAPV-------RDRVVIATKFgfgveegkp 156
Cdd:cd19112 11 MPVIGL-GVWRMEPGEIKELILNAIKIGYRHFDCAADYK---NEKEVGEALAEAfktglvkREDLFITTKL--------- 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490304600 157 tsLNSHPDHIRRAVEGSLKRLKTDHIDLLYQHRP-----------------------DPNVPIEDVAETVKALILEGKVK 213
Cdd:cd19112 78 --WNSDHGHVIEACKDSLKKLQLDYLDLYLVHFPvatkhtgvgttgsalgedgvldiDVTISLETTWHAMEKLVSAGLVR 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490304600 214 HWGLSEASARTIRRAHAvlpvtavQSEYAMWWREPETRIFPTLEELgigfVPYC------PTARSFLAGAVNPSQRFDST 287
Cdd:cd19112 156 SIGISNYDIFLTRDCLA-------YSKIKPAVNQIETHPYFQRDSL----VKFCqkhgisVTAHTPLGGAAANAEWFGSV 224
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490304600 288 DrrhnlPRFQPdalaknmVLLEFAQSWarrkNTTPVQFALAWVMaQRPWIVpIPGTTQYPHLIENSGAPQVRLTDRELRE 367
Cdd:cd19112 225 S-----PLDDP-------VLKDLAKKY----GKSAAQIVLRWGI-QRNTAV-IPKSSKPERLKENIDVFDFQLSKEDMKL 286
|
...
gi 490304600 368 IDA 370
Cdd:cd19112 287 IKS 289
|
|
| AKR_AKR4C1-15 |
cd19125 |
AKR4C family of aldo-keto reductase (AKR); The AKR4C family of AKR includes aldose reductase ... |
82-329 |
1.50e-08 |
|
AKR4C family of aldo-keto reductase (AKR); The AKR4C family of AKR includes aldose reductase (ALR) from Hordeum vulgare (AKR4C1), Bromus inermis (AKR4C2), Avena fatua (AKR4C3), and Xerophyta viscosa (AKR4C4), two aldose reductases, DpAR1 (AKR4C5) and DpAR2(AKR4C6), from Digitalis purpurea, aldehyde reductase from Zea mays (AKR4C7), four aldo-keto reductases from Arabidopsis thaliana (AKR4C8-11), and another three aldo-keto reductases from Aloe arborescens (AKR4C12) and Oryza sativa (AKR4C14/15). ALR (EC 1.1.1.21), also called AR, aldehyde reductase, or polyol dehydrogenase (NADP(+)), is a cytosolic NADPH-dependent oxidoreductase that catalyzes the reduction of a variety of aldehydes and carbonyls, including monosaccharides. Both DpAR1 and DpAR2 reduce the ketone group of steroid structures. They may be involved in plant steroid metabolism in general and in cardenolide biosynthesis in particular. Plant aldo-keto reductases of the AKR4C subfamily play key roles during stress and are attractive targets for developing stress-tolerant crops.
Pssm-ID: 381351 [Multi-domain] Cd Length: 287 Bit Score: 55.43 E-value: 1.50e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490304600 82 GCLPMVGY--YGGGPRDRKAMVsliRAAFEQGITFFDTAEVYGphlSEEFVGEALAPV-------RDRVVIATKFGfgve 152
Cdd:cd19125 9 AKIPAVGLgtWQADPGVVGNAV---KTAIKEGYRHIDCAAIYG---NEKEIGKALKKLfedgvvkREDLFITSKLW---- 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490304600 153 egkptsLNSH-PDHIRRAVEGSLKRLKTDHIDLLYQHRP----------DP-NVPIEDVAETVKA---LILEGKVKHWGL 217
Cdd:cd19125 79 ------CTDHaPEDVPPALEKTLKDLQLDYLDLYLIHWPvrlkkgahmpEPeEVLPPDIPSTWKAmekLVDSGKVRAIGV 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490304600 218 SEASARTIRRAHAVLPVT-AV-QSEYAMWWRepETRIFPTLEELGIGFVPYCPTARSflagavnpsqrfDSTDRRHNlpr 295
Cdd:cd19125 153 SNFSVKKLEDLLAVARVPpAVnQVECHPGWQ--QDKLHEFCKSKGIHLSAYSPLGSP------------GTTWVKKN--- 215
|
250 260 270
....*....|....*....|....*....|....
gi 490304600 296 fqpdaLAKNMVLLEFAQswarRKNTTPVQFALAW 329
Cdd:cd19125 216 -----VLKDPIVTKVAE----KLGKTPAQVALRW 240
|
|
| AKR_AKR5G1-3 |
cd19157 |
AKR5G family of aldo-keto reductase (AKR); Bacillus subtilis glyoxal reductase (GR), ... |
101-370 |
1.27e-07 |
|
AKR5G family of aldo-keto reductase (AKR); Bacillus subtilis glyoxal reductase (GR), uncharacterized oxidoreductase YtbE, and Bacillus aryabhattai aldo-keto reductase are founding members of aldo-keto reductase family 5 member G1-3 (AKR5G1-3), respectively. GR (YvgN, EC 1.1.1.283), also called methylglyoxal reductase, reduces glyoxal and methylglyoxal (2-oxopropanal). It is not involved in vitamin B6 biosynthesis.
Pssm-ID: 381383 [Multi-domain] Cd Length: 265 Bit Score: 52.39 E-value: 1.27e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490304600 101 VSLIRAAFEQGITFFDTAEVYGphlSEEFVGEALAPV---RDRVVIATKFgFGVEEGKPTSLnshpdhirRAVEGSLKRL 177
Cdd:cd19157 27 VNAVKTALKNGYRSIDTAAIYG---NEEGVGKGIKESgipREELFITSKV-WNADQGYDSTL--------KAFEASLERL 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490304600 178 KTDHIDLLYQHRPDPNVpiedVAETVKA---LILEGKVKHWGLSEASARTIRRAHAVLPVTAV--QSEYAMWWREPETRI 252
Cdd:cd19157 95 GLDYLDLYLIHWPVKGK----YKETWKAlekLYKDGRVRAIGVSNFQVHHLEDLLADAEIVPMvnQVEFHPRLTQKELRD 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490304600 253 FptLEELGIGFVPYCPtarsFLAGavnpsQRFDstdrrhnlprfqpdalakNMVLLEFAQSWarrkNTTPVQFALAWVMA 332
Cdd:cd19157 171 Y--CKKQGIQLEAWSP----LMQG-----QLLD------------------NPVLKEIAEKY----NKSVAQVILRWDLQ 217
|
250 260 270
....*....|....*....|....*....|....*...
gi 490304600 333 QRpwIVPIPGTTQYPHLIENSGAPQVRLTDRELREIDA 370
Cdd:cd19157 218 NG--VVTIPKSIKEHRIIENADVFDFELSQEDMDKIDA 253
|
|
| AKR_AKR1I_CgAKR1 |
cd19155 |
Coptotermes gestroi aldo-keto reductase (CgAKR-1) and similar proteins; Coptotermes gestroi ... |
104-369 |
1.83e-07 |
|
Coptotermes gestroi aldo-keto reductase (CgAKR-1) and similar proteins; Coptotermes gestroi aldo-keto reductase (CgAKR-1) is a founding member of aldo-keto reductase family 1 member I (AKR1I). It is a multipurpose enzyme with potential biotechnological applications.
Pssm-ID: 381381 [Multi-domain] Cd Length: 307 Bit Score: 52.14 E-value: 1.83e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490304600 104 IRAAFEQGITFFDTAEVYGphlSEEFVGEALAPV-------RDRVVIATKFgfgveegKPTSlnSHPDHIRRAVEGSLKR 176
Cdd:cd19155 31 VDTALEAGYRHIDTAYVYR---NEAAIGNVLKKWidsgkvkREELFIVTKL-------PPGG--NRREKVEKFLLKSLEK 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490304600 177 LKTDHIDLLYQHRP---------------------DPNVPIEDVAETVKALILEGKVKHWGLSEASARTIRR--AHAVLP 233
Cdd:cd19155 99 LQLDYVDLYLIHFPvgslskeddsgkldptgehkqDYTTDLLDIWKAMEAQVDQGLTRSIGLSNFNREQMARilKNARIK 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490304600 234 VTAVQSEYAMWWREPETRIFptLEELGIGFVPYCPTARSFLAgAVNPSqrfdstdrRHNLPRFQPDaLAKNMVLLEFAQs 313
Cdd:cd19155 179 PANLQVELHVYLQQKDLVDF--CSTHSITVTAYAPLGSPGAA-HFSPG--------TGSPSGSSPD-LLQDPVVKAIAE- 245
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*.
gi 490304600 314 warRKNTTPVQFALAWVMaQRPwIVPIPGTTQYPHLIENSGAPQVRLTDRELREID 369
Cdd:cd19155 246 ---RHGKSPAQVLLRWLM-QRG-VVVIPKSTNAARIKENFQVFDFELTEADMAKLS 296
|
|
| AKR_GlAR-like |
cd19128 |
Giardia lamblia aldose reductase (AR) and similar proteins; Giardia lamblia AR (EC 1.1.1.21), ... |
104-365 |
3.36e-07 |
|
Giardia lamblia aldose reductase (AR) and similar proteins; Giardia lamblia AR (EC 1.1.1.21), also called aldehyde reductase, is the prototype of this family. It catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols with a broad range of catalytic efficiencies.
Pssm-ID: 381354 [Multi-domain] Cd Length: 277 Bit Score: 51.37 E-value: 3.36e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490304600 104 IRAAFEQGITFFDTAEVYGphlSEEFVGEALAPV-------RDRVVIATKFGfgveegkPTslNSHPDHIRRAVEGSLKR 176
Cdd:cd19128 20 VKNAIKAGYRHIDCAYYYG---NEAFIGIAFSEIfkdggvkREDLFITSKLW-------PT--MHQPENVKEQLLITLQD 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490304600 177 LKTDHIDLLYQHRP---DPN----------------VPIEDVAETVKALILEGKVKHWGLSEASARTIRR--AHAVLPVT 235
Cdd:cd19128 88 LQLEYLDLFLIHWPlafDMDtdgdprddnqiqslskKPLEDTWRAMEQCVDEKLTKNIGVSNYSTKLLTDllNYCKIKPF 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490304600 236 AVQSEYAMWWrePETRIFPTLEELGIGFVPYCPTARSFLAGAVNPsqrfdstdrrhnlprfQPDALAKNMvllefaqswA 315
Cdd:cd19128 168 MNQIECHPYF--QNDKLIKFCIENNIHVTAYRPLGGSYGDGNLTF----------------LNDSELKAL---------A 220
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|..
gi 490304600 316 RRKNTTPVQFALAWVMAQRP--WIVpIPGTTQYPHLIENSGAPQVRLTDREL 365
Cdd:cd19128 221 TKYNTTPPQVIIAWHLQKWPknYSV-IPKSANKSRCQQNFDINDLALTKEDM 271
|
|
| dkgA |
PRK11565 |
2,5-didehydrogluconate reductase DkgA; |
101-218 |
3.87e-07 |
|
2,5-didehydrogluconate reductase DkgA;
Pssm-ID: 183203 [Multi-domain] Cd Length: 275 Bit Score: 51.23 E-value: 3.87e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490304600 101 VSLIRAAFEQGITFFDTAEVYGphlSEEFVGEALAPV---RDRVVIATKFgfgveegkptsLNSHPDHIRRAVEGSLKRL 177
Cdd:PRK11565 31 ITAIHKALEVGYRSIDTAAIYK---NEEGVGKALKEAsvaREELFITTKL-----------WNDDHKRPREALEESLKKL 96
|
90 100 110 120
....*....|....*....|....*....|....*....|....
gi 490304600 178 KTDHIDLLYQHRPDPnvPIEDVAETVKALIL---EGKVKHWGLS 218
Cdd:PRK11565 97 QLDYVDLYLMHWPVP--AIDHYVEAWKGMIElqkEGLIKSIGVC 138
|
|
| AKR_AKR1A1-4 |
cd19106 |
AKR1A family of aldo-keto reductase (AKR); The AKR1A family of AKR includes alcohol ... |
104-370 |
1.47e-06 |
|
AKR1A family of aldo-keto reductase (AKR); The AKR1A family of AKR includes alcohol dehydrogenase [NADP(+)] (ALR, EC 1.1.1.2) from Homo sapiens (AKR1A1), Sus scrofa (AKR1A2), Rattus norvegicus (liver, AKR1A3), and Mus musculus (AKR1A4). ALR, also known as aldehyde reductase, or ALDR1, catalyzes the NADPH-dependent reduction of a variety of aromatic and aliphatic aldehydes to their corresponding alcohols. In vitro substrates include succinic semialdehyde, 4-nitrobenzaldehyde, 1,2-naphthoquinone, methylglyoxal, and D-glucuronic acid.
Pssm-ID: 381332 [Multi-domain] Cd Length: 305 Bit Score: 49.31 E-value: 1.47e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490304600 104 IRAAFEQGITFFDTAEVYGphlSEEFVGEAL--------APVRDRVVIATKFgfgveegkptsLNS--HPDHIRRAVEGS 173
Cdd:cd19106 26 VKYALDAGYRHIDCAAVYG---NEQEVGEALkekvgpgkAVPREDLFVTSKL-----------WNTkhHPEDVEPALRKT 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490304600 174 LKRLKTDHIDLLYQHRP------------DPNVPIE----DVAETVKA---LILEGKVKHWGLSEASARTI-------RR 227
Cdd:cd19106 92 LKDLQLDYLDLYLIHWPyafergdnpfpkNPDGTIRydstHYKETWKAmekLVDKGLVKAIGLSNFNSRQIddilsvaRI 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490304600 228 AHAVLPVtavqseyamwwrepETRIFPTLEELgigfVPYCpTARSFLAGAVNPsqrFDSTDRrhnlPRFQPDalakNMVL 307
Cdd:cd19106 172 KPAVLQV--------------ECHPYLAQNEL----IAHC-KARGLVVTAYSP---LGSPDR----PWAKPD----EPVL 221
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 490304600 308 LEFA--QSWARRKNTTPVQFALAWVMaQRPwIVPIPGTTQYPHLIENSGAPQVRLTDRELREIDA 370
Cdd:cd19106 222 LEEPkvKALAKKYNKSPAQILLRWQV-QRG-VVVIPKSVTPSRIKQNIQVFDFTLSPEEMKQLDA 284
|
|
| AKR_AKR3A1-2 |
cd19117 |
AKR3A family of aldo-keto reductase (AKR); Saccharomyces cerevisiae Gcy1p and Ypr1p are ... |
104-369 |
1.91e-06 |
|
AKR3A family of aldo-keto reductase (AKR); Saccharomyces cerevisiae Gcy1p and Ypr1p are founding members of aldo-keto reductase family 3 member A1 (AKR3A1) and A2 (AKR3A2), respectively. Gcy1p, also called galactose-inducible crystallin-like protein 1, is a glycerol dehydrogenase involved in glycerol catabolism under microaerobic conditions. It has mRNA binding activity. Ypr1p acts as a 2-methylbutyraldehyde reductase that displays high specific activity towards 2-methylbutyraldehyde, as well as other aldehydes such as hexanal.
Pssm-ID: 381343 [Multi-domain] Cd Length: 284 Bit Score: 49.03 E-value: 1.91e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490304600 104 IRAAFEQGITFFDTAEVYGphlSEEFVGEAL----APvRDRVVIATKFGfgveegkptslNSHPDHIRRAVEGSLKRLKT 179
Cdd:cd19117 33 VEAALKAGYRHIDTAAIYG---NEEEVGQGIkdsgVP-REEIFITTKLW-----------CTWHRRVEEALDQSLKKLGL 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490304600 180 DHIDLLYQHRPDPNVP---------------------IEDVAETVKALILEGKVKHWGLSEASARTIRRAHAvlpvtavq 238
Cdd:cd19117 98 DYVDLYLMHWPVPLDPdgndflfkkddgtkdhepdwdFIKTWELMQKLPATGKVKAIGVSNFSIKNLEKLLA-------- 169
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170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490304600 239 seyamwwrEPETRIFPTLEELGI-------GFVPYCpTARSFLAGAVNPsqrFDSTDrrhnlprfqpDALAKNMVLLEFA 311
Cdd:cd19117 170 --------SPSAKIVPAVNQIELhpllpqpKLVDFC-KSKGIHATAYSP---LGSTN----------APLLKEPVIIKIA 227
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*...
gi 490304600 312 QSwarrKNTTPVQFALAWvMAQRPWIVpIPGTTQyPHLIENSGApQVRLTDRELREID 369
Cdd:cd19117 228 KK----HGKTPAQVIISW-GLQRGYSV-LPKSVT-PSRIESNFK-LFTLSDEEFKEID 277
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| AKR_AKR3C1 |
cd19119 |
Saccharomyces cerevisiae D-arabinose dehydrogenase [NAD(P)+] heavy chain (Ara1p) and similar ... |
84-211 |
2.01e-06 |
|
Saccharomyces cerevisiae D-arabinose dehydrogenase [NAD(P)+] heavy chain (Ara1p) and similar proteins; Saccharomyces cerevisiae Ara1p (EC 1.1.1.117), also called D-arabinose 1-dehydrogenase (NAD(P)(+)), is a founding members of aldo-keto reductase family 3 member C1 (AKR3C1). It catalyzes the oxidation of D-arabinose, L-xylose, L-fucose, and L-galactose in the presence of NADP(+).
Pssm-ID: 381345 [Multi-domain] Cd Length: 294 Bit Score: 49.03 E-value: 2.01e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490304600 84 LPMVGYYGGGPRDRKAMV-SLIRAAFEQGITFFDTAEVYGphlSEEFVGEALAPV-------RDRVVIATKFGfgveegk 155
Cdd:cd19119 12 IPALGLGTASPHEDRAEVkEAVEAAIKEGYRHIDTAYAYE---TEDFVGEAIKRAiddgsikREELFITTKVW------- 81
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*.
gi 490304600 156 PTSLnshpDHIRRAVEGSLKRLKTDHIDLLYQHRPDPNVPIEDvaETVKALILEGK 211
Cdd:cd19119 82 PTFY----DEVERSLDESLKALGLDYVDLLLVHWPVCFEKDSD--DSGKPFTPVND 131
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| AKR_AKR5C1 |
cd19130 |
Corynebacterium sp. 2,5-diketo-D-gluconic acid reductase A (DkgA) and similar proteins; ... |
84-192 |
7.87e-06 |
|
Corynebacterium sp. 2,5-diketo-D-gluconic acid reductase A (DkgA) and similar proteins; Corynebacterium sp. DkgA is a founding member of aldo-keto reductase family 5 member C1 (AKR5C1). DkgA (EC 1.1.1.346), also called 2,5-DKG reductase A, or 2,5-DKGR A, or 25DKGR-A, or AKR5C, catalyzes the reduction of 2,5-diketo-D-gluconic acid (25DKG) to 2-keto-L-gulonic acid (2KLG). 5-keto-D-fructose and dihydroxyacetone can also serve as substrates.
Pssm-ID: 381356 [Multi-domain] Cd Length: 256 Bit Score: 46.83 E-value: 7.87e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490304600 84 LPMVGY--YGGGPRDRKAMVSlirAAFEQGITFFDTAEVYGphlSEEFVGEALAP---VRDRVVIATKFGfgveegkptS 158
Cdd:cd19130 10 IPQLGYgvFKVPPADTQRAVA---TALEVGYRHIDTAAIYG---NEEGVGAAIAAsgiPRDELFVTTKLW---------N 74
|
90 100 110
....*....|....*....|....*....|....
gi 490304600 159 LNSHPDHIRRAVEGSLKRLKTDHIDLLYQHRPDP 192
Cdd:cd19130 75 DRHDGDEPAAAFAESLAKLGLDQVDLYLVHWPTP 108
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| AKR_AKR3B1-3 |
cd19118 |
AKR3B family of aldo-keto reductase (AKR); Sporidiobolus salmonicolor NADPH-dependent aldehyde ... |
84-225 |
9.45e-06 |
|
AKR3B family of aldo-keto reductase (AKR); Sporidiobolus salmonicolor NADPH-dependent aldehyde reductase 1 (ARI, EC 1.1.1.2), Trichosporonoides megachilieni NADPH-dependent erthyrose reductase (ER) 1/2 and 3, are founding members of aldo-keto reductase family 3 member B1 (AKR3B1), B2 (AKR3B2), and B3 (AKR3B3), respectively. Sporidiobolus salmonicolor NADPH-ARI, also called alcohol dehydrogenase [NADP(+)], or aldehyde reductase I, or ALR 1, catalyzes the asymmetric reduction of aliphatic and aromatic aldehydes and ketones to an R-enantiomer. It reduces ethyl 4-chloro-3-oxobutanoate to ethyl (R)-4-chloro-3-hydroxybutanoate. Trichosporonoides megachilieni NADPH-ERs catalyze the reduction of D-erythrose.
Pssm-ID: 381344 [Multi-domain] Cd Length: 283 Bit Score: 47.02 E-value: 9.45e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490304600 84 LPMVGY--YGGGPRDRKAMVsliRAAFEQGITFFDTAEVYGphlSEEFVGEALAPVRDRVViatkfGFGVEEGKPTSL-- 159
Cdd:cd19118 7 IPAIGLgtWQAEPGEVGAAV---KIALKAGYRHLDLAKVYQ---NQHEVGQALKELLKEEP-----GVKREDLFITSKlw 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490304600 160 -NSH-PDHIRRAVEGSLKRLKTDHIDLLYQHRP------------------------DPNVPIEDVAETVKALILEGKVK 213
Cdd:cd19118 76 nNSHrPEYVEPALDDTLKELGLDYLDLYLIHWPvafkptgdlnpltavptnggevdlDLSVSLVDTWKAMVELKKTGKVK 155
|
170
....*....|..
gi 490304600 214 HWGLSEASARTI 225
Cdd:cd19118 156 SIGVSNFSIDHL 167
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| AKR_AKR5A_5G |
cd19126 |
AKR5A and AKR5G families of aldo-keto reductase (AKR); The AKR5A family of AKR includes ... |
104-370 |
4.40e-05 |
|
AKR5A and AKR5G families of aldo-keto reductase (AKR); The AKR5A family of AKR includes prostaglandin F2-alpha synthase (PGFS) from Leishmania major (AKR5A1) and Trypanosoma brucei (AKR5A2). PGFS, also called 9,11-endoperoxide prostaglandin H2 reductase, catalyzes the NADP-dependent formation of prostaglandin F2-alpha from prostaglandin H2. It has also aldo/ketoreductase activity for synthetic substrates 9,10-phenanthrenequinone and p-nitrobenzaldehyde. The AKR5G family of AKR includes Bacillus subtilis glyoxal reductase (GR), uncharacterized oxidoreductase YtbE, and Bacillus aryabhattai aldo-keto reductase, which corresponds to aldo-keto reductase family 5 member G1-3 (AKR5G1-3), respectively. GR (YvgN, EC 1.1.1.283), also called methylglyoxal reductase, reduces glyoxal and methylglyoxal (2-oxopropanal). It is not involved in vitamin B6 biosynthesis.
Pssm-ID: 381352 [Multi-domain] Cd Length: 254 Bit Score: 44.74 E-value: 4.40e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490304600 104 IRAAFEQGITFFDTAEVYGphlSEEFVGEALAPV---RDRVVIATKFgFGVEEGKPTSLNshpdhirrAVEGSLKRLKTD 180
Cdd:cd19126 29 VQTALENGYRSIDTAAIYK---NEEGVGEAIRESgvpREELFVTTKL-WNDDQRARRTED--------AFQESLDRLGLD 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490304600 181 HIDLLYQHRPDPnvpiEDVAETVKAL---ILEGKVKHWGLSEASARTIRR--AHAVLPVTAVQSEYAMWWREPETRIFpt 255
Cdd:cd19126 97 YVDLYLIHWPGK----DKFIDTWKALeklYASGKVKAIGVSNFQEHHLEEllAHADVVPAVNQVEFHPYLTQKELRGY-- 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490304600 256 LEELGIgfvpyCPTARSFLAGAvnpsqrfdstdrrhnlprfqpdALAKNMVLLEFAQSWARrkntTPVQFALAWVMaQRP 335
Cdd:cd19126 171 CKSKGI-----VVEAWSPLGQG----------------------GLLSNPVLAAIGEKYGK----SAAQVVLRWDI-QHG 218
|
250 260 270
....*....|....*....|....*....|....*
gi 490304600 336 wIVPIPGTTQYPHLIENSGAPQVRLTDRELREIDA 370
Cdd:cd19126 219 -VVTIPKSVHASRIKENADIFDFELSEDDMTAIDA 252
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| AKR_AKR3D1 |
cd19121 |
AKR3D family of aldo-keto reductase (AKR); Trichoderma reesei D-galacturonate reductase (GAR1, ... |
74-195 |
4.47e-04 |
|
AKR3D family of aldo-keto reductase (AKR); Trichoderma reesei D-galacturonate reductase (GAR1, EC 1.1.1.365), also called D-galacturonic acid reductase, or GalUR, is a founding member of aldo-keto reductase family 3 member D1 (AKR3D1). It mediates the reduction of D-galacturonate to L-galactonate, the first step in D-galacturonate catabolic process. It also has activity with D-glucuronate and DL-glyceraldehyde. Its activity is seen only with NADPH and not with NADH.
Pssm-ID: 381347 [Multi-domain] Cd Length: 279 Bit Score: 41.75 E-value: 4.47e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490304600 74 LEVSSMGLGClpmvgYYGGGPRDRKAMVSLIRAafeqGITFFDTAEVYGphlSEEFVG----EALAPV--RDRVVIATKF 147
Cdd:cd19121 10 ASIPAVGLGT-----WQAKAGEVKAAVAHALKI----GYRHIDGALCYQ---NEDEVGegikEAIAGGvkREDLFVTTKL 77
|
90 100 110 120
....*....|....*....|....*....|....*....|....*...
gi 490304600 148 gfgveegkptsLNSHPDHIRRAVEGSLKRLKTDHIDLLYQHRPDPNVP 195
Cdd:cd19121 78 -----------WSTYHRRVELCLDRSLKSLGLDYVDLYLVHWPVLLNP 114
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| AKR_AKR5H1 |
cd19134 |
AKR5H family of aldo-keto reductase (AKR); Mycobacterium smegmatis MSMEG_2407 is a founding ... |
84-194 |
1.20e-03 |
|
AKR5H family of aldo-keto reductase (AKR); Mycobacterium smegmatis MSMEG_2407 is a founding member of aldo-keto reductase family 5 member H1 (AKR5H1). It is a NADPH-dependent aldo-keto reductase that reduces methylglyoxal and phenylglyoxal.
Pssm-ID: 381360 [Multi-domain] Cd Length: 263 Bit Score: 40.22 E-value: 1.20e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490304600 84 LPMVGYYGGGPRDRKAMVSlIRAAFEQGITFFDTAEVYGphlSEEFVGEALAPV---RDRVVIATKFgfgveegkptsln 160
Cdd:cd19134 11 MPVIGLGVGELSDDEAERS-VSAALEAGYRLIDTAAAYG---NEAAVGRAIAASgipRGELFVTTKL------------- 73
|
90 100 110
....*....|....*....|....*....|....*...
gi 490304600 161 SHPDH----IRRAVEGSLKRLKTDHIDLLYQHRPDPNV 194
Cdd:cd19134 74 ATPDQgftaSQAACRASLERLGLDYVDLYLIHWPAGRE 111
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| AKR_AKR5A1_2 |
cd19156 |
AKR5A family of aldo-keto reductase (AKR); Prostaglandin F2-alpha synthase (PGFS) from ... |
101-218 |
1.85e-03 |
|
AKR5A family of aldo-keto reductase (AKR); Prostaglandin F2-alpha synthase (PGFS) from Leishmania major and Trypanosoma brucei are founding members of aldo-keto reductase family 5 member A1 (AKR5A1) and A2 (AKR5A2), respectively. PGFS, also called 9,11-endoperoxide prostaglandin H2 reductase, catalyzes the NADP-dependent formation of prostaglandin F2-alpha from prostaglandin H2. It has also aldo/ketoreductase activity toward the synthetic substrates 9,10-phenanthrenequinone and p-nitrobenzaldehyde.
Pssm-ID: 381382 [Multi-domain] Cd Length: 266 Bit Score: 39.81 E-value: 1.85e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490304600 101 VSLIRAAFEQGITFFDTAEVYGphlSEEFVGEALAPV---RDRVVIATKFgFGVEEGKPTSLnshpdhirRAVEGSLKRL 177
Cdd:cd19156 26 ENAVKWAIEAGYRHIDTAAIYK---NEEGVGQGIRESgvpREEVFVTTKL-WNSDQGYESTL--------AAFEESLEKL 93
|
90 100 110 120
....*....|....*....|....*....|....*....|.
gi 490304600 178 KTDHIDLLYQHRPDPNvPIEDVAETVKALILEGKVKHWGLS 218
Cdd:cd19156 94 GLDYVDLYLIHWPVKG-KFKDTWKAFEKLYKEKKVRAIGVS 133
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