|
Name |
Accession |
Description |
Interval |
E-value |
| PRK05122 |
PRK05122 |
major facilitator superfamily transporter; Provisional |
1-395 |
6.56e-165 |
|
major facilitator superfamily transporter; Provisional
Pssm-ID: 235348 [Multi-domain] Cd Length: 399 Bit Score: 467.83 E-value: 6.56e-165
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490303209 1 MSTSVSTTQLNLRIISIVVFTCICYLSIGLPLAVLPGYIHYQLGYSTFVAGIVISLQYISTLISRPHAGRYTDIWGPKKV 80
Cdd:PRK05122 4 AEPALSGLRLTLRIVSIVMFTFISYLTIGLPLAVLPGYVHDQLGFSAFLAGLVISLQYLATLLSRPHAGRYADTLGPKKA 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490303209 81 VSLGIVCCLLSGAFTLLAVALQATPMLAIAALLAGRVFLGVGESFTATGATLWGIKTVGAIHTSRVISWNGVATYVAMAV 160
Cdd:PRK05122 84 VVFGLCGCALSGLLYLLAGLLAAWPVLSLLLLLLGRLLLGIGESLAGTGSILWGIGRVGALHTGRVISWNGIATYGALAI 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490303209 161 GAPLGVTLNHYFGISGFATVVVLVAAIGLLFARTRQDVKVTAGARAPFHSVVRKIWPYGLGLAFGTVGFGVIATFITLYF 240
Cdd:PRK05122 164 GAPLGVLLYHWGGLAGLGLLIMLLALLGLLLARPRPAVPPVKGERLPFRRVLGRVWPYGMGLALASIGFGTIATFITLYY 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490303209 241 AAHSWQGAAFTLSLFSVGFICVRLVLGNTITRFGGVPVSLACFIIESLGLLLIWLAPSAWMAGVGAFLTGSGFSLVFPAL 320
Cdd:PRK05122 244 AARGWDGAALALTLFGVAFVGARLLFGNLINRLGGLRVAIVSLLVEILGLLLLWLAPSPWMALIGAALTGFGFSLVFPAL 323
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 490303209 321 GVEAVKQVEEQNQGTALGTYSAFLDLALGLTGPLAGWVAGFYDLATLYLLAAIVVALAFLLIFRVHRQQRLVARE 395
Cdd:PRK05122 324 GVEAVKRVPPQNRGAALGAYSVFLDLSLGITGPLAGLVASWFGYPSIFLAAALAALLGLALTWLLYRRAPRAVPE 398
|
|
| PRK12382 |
PRK12382 |
putative transporter; Provisional |
15-389 |
1.05e-109 |
|
putative transporter; Provisional
Pssm-ID: 183487 [Multi-domain] Cd Length: 392 Bit Score: 327.02 E-value: 1.05e-109
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490303209 15 ISIVVFtcICYLSIGLPLAVLPGYIHYQLGYSTFVAGIVISLQYISTLISRPHAGRYTDIWGPKKVVSLGIVCCLLSGAF 94
Cdd:PRK12382 20 IAFAVF--LTYMTVGLPLPVIPLFVHHDLGFGNTMVGIAVGIQFLATVLTRGYAGRLADQYGAKRSALQGMLACGLAGLA 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490303209 95 TLLAVALQATPMLAIAALLAGRVFLGVGESFTATGATLWGIKTVGAIHTSRVISWNGVATYVAMAVGAPLGVTLNHYFGI 174
Cdd:PRK12382 98 YLLAAILPVSAPFKFALLVVGRLILGFGESQLLTGALTWGLGLVGPKHSGKVMSWNGMAMYGALAAGAPLGLLLHSHFGF 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490303209 175 SGFATVVVLVAAIGLLFARTRQDVKVTAGARAPFHSVVRKIWPYGLGLAFGTVGFGVIATFITLYFAAHSWQGAAFTLSL 254
Cdd:PRK12382 178 AALALTTMVLPLLAWAFNGTVRKVPAHAGERPSLWSVVGLIWKPGLGLALQGVGFAVIGTFVSLYFASKGWAMAGFTLTA 257
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490303209 255 FSVGFICVRLVLGNTITRFGGVPVSLACFIIESLGLLLIWLAPSAWMAGVGAFLTGSGFSLVFPALGVEAVKQVEEQNQG 334
Cdd:PRK12382 258 FGGAFVLMRVLFGWMPDRFGGVKVAIVSLLVETVGLLLLWLAPTAWVALAGAALTGAGCSLIFPALGVEVVKRVPSQVRG 337
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*
gi 490303209 335 TALGTYSAFLDLALGLTGPLAGWVAGFYDLATLYLLAAIVVALAFLLIFRVHRQQ 389
Cdd:PRK12382 338 TALGGYAAFQDIAYGVSGPLAGMLATSFGYPSVFLAGAISAVLGIIVTILSFRRG 392
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
17-381 |
6.46e-73 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 232.10 E-value: 6.46e-73
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490303209 17 IVVFTCICYLSIGLPLAVLPGYIHyQLGYSTFVAGIVISLQYISTLISRPHAGRYTDIWGPKKVVSLGIVCCLLSGAFTL 96
Cdd:cd17489 1 ILLANFFFFLSFYLLLPVLPLYAH-DLGGSEAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490303209 97 LAVAlqatpmlaIAALLAGRVFLGVGESFTATGATLWGIKTVGAIHTSRVISWNGVATYVAMAVGAPLGVTLNHYFGISG 176
Cdd:cd17489 80 LATS--------VALLLVLRLIHGIGWGAFTTAAATLVADIIPPSRRGEGIGYYGLATTLAMALGPALGLFLYQHLGFAV 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490303209 177 FATVVVLVAAIGLLFARTRQDVKVTAGA------RAPFHSVVRKIWPYGLGLAFGTVGFGVIATFITLYFAAHSWQGAAF 250
Cdd:cd17489 152 LFIVAAVLALLALLLVFLVKDPPPVAAEeaeagtRAFRRLVEKKVLPPALILFLASIAYGAISTFLPLYAAERGISNAGL 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490303209 251 TLSLFSVGFICVRLVLGNTITRFGGVPVSLACFIIESLGLLLIWLAPSAWMAGVGAFLTGSGFSLVFPALGVEAVKQVEE 330
Cdd:cd17489 232 FFTVYAIALLLSRPFSGKLSDRKGPKTVIIPGLLLLALGLLLLSFAGSPWMLLLAAVLYGLGFGLLFPALQALAVDLVPP 311
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|.
gi 490303209 331 QNQGTALGTYSAFLDLALGLTGPLAGWVAGFYDLATLYLLAAIVVALAFLL 381
Cdd:cd17489 312 HRRGAANGTFFIFFDLGIGLGGLLLGLVAELFGYRAMFLLAAVVVLLALVL 362
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
21-384 |
1.81e-29 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 117.29 E-value: 1.81e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490303209 21 TCICYLSIGLPLAVLPGYIHyQLGYSTFVAGIVISLQYISTLISRPHAGRYTDIWGPKKVVSLGIvccLLSGAFTLLAVA 100
Cdd:cd17325 5 LFLDMLGYGIIIPILPLYAE-SLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGL---LLLAVSTLLFAF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490303209 101 LQATPMLAIAallagRVFLGVGESFTATGATLWGIKTVGAIHTSRVISWNGVATYVAMAVGAPLGVTLNHYFGISG---F 177
Cdd:cd17325 81 ATSYWQLLLA-----RFLQGLASAAVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRApflV 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490303209 178 ATVVVLVAAIGLLFARTRQDVKVTAGARAPFHS--------VVRKIWPYGLGLAFGTVGFGVIATFITLYFAAH---SWQ 246
Cdd:cd17325 156 CAALALLALVLALLLLPEPRPPPNKRAVSAARLrsglrlllRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELgglSPA 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490303209 247 GAAFTLSLFSVGFICVRLVLGNTITRFGGVPVSLACFIIESLGLLLIWLAPSAWMAGVGAFLTGSGFSLVFPALGVEAVK 326
Cdd:cd17325 236 QIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVALLLLPLATSFWLLLLLLALLGLGLGLVFPATLALLAD 315
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*...
gi 490303209 327 QVEEQNQGTALGTYSAFLDLALGLTGPLAGWVAGFYDLATLYLLAAIVVALAFLLIFR 384
Cdd:cd17325 316 IVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAFGFATPFLAAAALLLLAAVLFLL 373
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
1-347 |
4.89e-24 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 101.59 E-value: 4.89e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490303209 1 MSTSVSTTQLNLRIISIVVFtcICYLSIGLPLAVLPgYIHYQLGYSTFVAGIVISLQYISTLISRPHAGRYTDIWGPKKV 80
Cdd:COG2814 1 MPATPRRRWLALLALALGAF--LSGLGIGIVLPALP-LIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRV 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490303209 81 VSLGIVCCLLSGAFTLLAVAlqatpmlaIAALLAGRVFLGVGESFTATGATLWGIKTVGAIHTSRVISWNGVATYVAMAV 160
Cdd:COG2814 78 LLLGLLLFALGSLLCALAPS--------LWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPAL 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490303209 161 GAPLGVTLNHYFGISGFATVVVLVAAIGLLFA-----RTRQDVKVTAGARAPFHSVVRKIWPYGLGLAFGTVGFGVIATF 235
Cdd:COG2814 150 GPLLGGLLADLFGWRWVFLVNAVLALLALLLLlrllpESRPAARARLRGSLRELLRRPRLLLLLLLAFLLGFGFFALFTY 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490303209 236 ITLYFAAH---SWQGAAFTLSLFSVGFICVRLVLGNTITRFGGVPVSLACFIIESLGLLLIWLAPSAWMAGVGAFLTGSG 312
Cdd:COG2814 230 LPLYLQEVlglSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALGLLLLALAGSLWLLLLALFLLGFG 309
|
330 340 350
....*....|....*....|....*....|....*
gi 490303209 313 FSLVFPALGVEAVKQVEEQNQGTALGTYSAFLDLA 347
Cdd:COG2814 310 FGLLFPLLQALVAELAPPEARGRASGLYNSAFFLG 344
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
17-390 |
2.17e-18 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 86.06 E-value: 2.17e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490303209 17 IVVFTCICYLSIGLPLAVLP---GYIHYQLGYSTFVAGIVISLQYISTLISRPHAGRYTDIWGPKKVVSLGIVCCLLSGA 93
Cdd:COG0738 9 ALIAIYLLFFLWGFATALWGpliPALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMALGLL 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490303209 94 FTLLAVALqatpmlaiAALLAGRVFLGVGESFTATGATLWGIkTVGAIHTSRVISW----NGVATYVAMAVGA-----PL 164
Cdd:COG0738 89 LFALAPSY--------PLLLLALFLLGLGLGLLDVAANPYVA-ALGPETAASRLNLlhafFSLGALLGPLLGGllillGL 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490303209 165 GVTLNHYFGISGFATVVVLVAAIGLLFARTRQDVKVTAGARAPFHSVVRK--IWPYGLGLAFGTVGFGVIATFITLYFAA 242
Cdd:COG0738 160 SLSWHLPYLILAVLLLLLALLFLRSKLPEIEEEEEEAAGSAASLKSLLKNprLLLGGLAIFLYVGAEGAIGDWLPLYLKD 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490303209 243 H---SWQGAAFTLSLFSVGFICVRLVLGNTITRFGGVPVSLACFIIESLGLLLIWLAPSAWMAGVGAFLTGSGFSLVFPA 319
Cdd:COG0738 240 VlglSEATAALGLSLFWGGMTIGRFLGGFLLKRFGPVRLLRLSALLAAVGLLLALLAPGPWLALIGLALVGLGLSLMFPT 319
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 490303209 320 LGVEAVKQVEEqNQGTALGTYSAFLDLALGLTGPLAGWVAGFYDLATLYLLAAIVVALAFLLIFRVHRQQR 390
Cdd:COG0738 320 IFSLALDGLGK-RTAAAVSAVLIMGIVGGAIGPPLIGFLADAFGLRAAFLVPLVCYLLILLLALALKRKRR 389
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
34-383 |
9.89e-17 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 80.70 E-value: 9.89e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490303209 34 VLPGYIHYQLGYSTFVAGIVISLQYISTLISRPHAGRYTDIWGPKKVVSLGIVCCLLSGAFTLLAVALQAtpmlaiaaLL 113
Cdd:cd17473 21 ALPAIAQHFVPNSELLVPLLLTLPALFIALFAPLAGWLADRFGRKRLLIAGLLLYGIGGVAGLFLDSLYA--------LL 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490303209 114 AGRVFLGVGESFTATGAT-LWGIKTVGAiHTSRVISWNGVATY----VAMAVGAPLGVTLNHY-FGISGFATVVVLVAAI 187
Cdd:cd17473 93 ASRALLGIGVAGIMTLATaLIGDYFEGE-ERAKMLGLQSAAMSlggvVFLLLGGALAEIGWRApFLVYLLALPVLILVLL 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490303209 188 GLLFARTRQDVKVTAGARAPFHSVVRKIWPYGLGLAFGTVGFGVIATFITLYFAA---HSWQGAAFTLSLFSVGFICVRL 264
Cdd:cd17473 172 FLPEPARKSKSAASPGAATAAALPWKRVLPIYFLAFLAMLLFYVIPIQLPFLLQErggGSAALIGLALAIASLAGAIGAL 251
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490303209 265 VLGNTITRFGGVPVSLACFIIESLGLLLIWLAPSAWMAGVGAFLTGSGFSLVFPALGVEAVKQVEEQNQGTALGTYSAFL 344
Cdd:cd17473 252 LFGRLKRRLGKRRLLAIGFALMALGFLLLALASGLWVVLLGAILAGLGFGLLLPTLNSWAMSLVPPELRGRAMGIVTSAF 331
|
330 340 350 360
....*....|....*....|....*....|....*....|
gi 490303209 345 DLALGLTGPLAGW-VAGFYDLATLYLLAAIVVALAFLLIF 383
Cdd:cd17473 332 FLGQFLSPLVLGPlVNLTGGLSGAFLILGVLALVLAIVLL 371
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
41-384 |
5.80e-16 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 78.81 E-value: 5.80e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490303209 41 YQLGYSTFVAGIVISLQYISTLISRPHAGRYTDIWGPKKVVslgIVCCLLSGAFTLLAVALQATPMLAIAALLAGRVFLG 120
Cdd:cd06173 27 LQLTGSALLVGLVLAAFFLPFLLFSPFAGVLADRFDRRRLL---ILADLLRALLAAVLALLALLGSLSLWLLLVLAFLLG 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490303209 121 VGESFTATGATLWGIKTVGAIHTSRVISWNGVATYVAMAVGAPLGVTLNHYFGISG-FATVVVLVAAIGLLFARTRQDVK 199
Cdd:cd06173 104 IASAFFGPARQALLPELVPKEQLVRANALNSLATQLARIIGPALGGLLVALLGPGGaFAINALSFLLSALLLLFIRRPPP 183
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490303209 200 VTAGARAPFHS--------VVRKIWPYGLGLAFGTVGFGVIATFITL--YFAAHSWQGAAFTLSL----FSVGFICVRLV 265
Cdd:cd06173 184 AAPGESSSLLLrdlreglrYLRRSPLLRLLLLALALFALLGGALTVLlpLLAKEVLGGGAAGYGLllaaFGVGALLGALL 263
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490303209 266 LGNTITRFGGVPVSLACFIIESLGLLLIWLAPSAWMAGVGAFLTGSGFSLVFPALGVEAVKQVEEQNQGTALGTYSAFLD 345
Cdd:cd06173 264 LGRLSKRRRRGRLLLIGALLLGLALLVLGLSPSLWLLLAALFLLGLAGGLFNVPLNTLLQLRVPDELRGRVFSVYNALNS 343
|
330 340 350
....*....|....*....|....*....|....*....
gi 490303209 346 LALGLTGPLAGWVAGFYDLATLYLLAAIVVALAFLLIFR 384
Cdd:cd06173 344 GAMPLGALLAGLLADALGLSAVFLLAGALLLLAALLLLL 382
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
17-390 |
6.77e-15 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 75.29 E-value: 6.77e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490303209 17 IVVFTCICYLSIGLPLAVLP---GYIHYQLGYSTFVAGIVISLQYISTLISRPHAGRYTDIWGPKKVVSLGIVCCLLSGA 93
Cdd:COG2271 11 ILALLFLAYFLNYLDRSNLSvaaPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGLATL 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490303209 94 FTLLAVALqatpmlaiAALLAGRVFLGVGESFTATGATLWGIKTVGAIHTSRVISWNGVATYVAMAVGAPLGVTLNHYFG 173
Cdd:COG2271 91 LFGFATSF--------WQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAAFG 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490303209 174 ISGFATVVVLVAAIGLLFArtrqdvkvtagarapfhsvvrkIWPYGLGLAFGTVGFGVIATFITLYFAAH---SWQGAAF 250
Cdd:COG2271 163 WRAAFLILGLPGLLLALLR----------------------FWLLALAYFLVYFALYGFLTWLPTYLVEVrglSLAQAGL 220
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490303209 251 TLSLFSVGFICVRLVLGNTITRFG--GVPVSLACFIIESLGLLLIWLAPSAWMAGVGAFLTGSGFSLVFPALGVEAVKQV 328
Cdd:COG2271 221 LLSLPFLAGIVGSLLGGWLSDRLGrrRKLVLAIGLLLAALALLLLALLPSPALAIALLFLAGFGLGGAFGLLWALAAELF 300
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 490303209 329 EEQNQGTALGTYSAFLDLALGLTGPLAGWVAGFYDLATLYLLAAIVVALAFLLIFRVHRQQR 390
Cdd:COG2271 301 PKKARGTASGLVNTFGFLGGALGPLLVGYLLDATGYQAAFLLLAALALLAALLALLLLRETR 362
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
10-393 |
8.31e-14 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 72.22 E-value: 8.31e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490303209 10 LNLRIISIVVFTCICYLSIglpLAVLPGYIHYQLGYSTFVAGIVISLQYISTLISRPHAGRYTDIWGPKKVVSLGIVCCL 89
Cdd:COG2223 5 RVLLLATLAFFLAFGVWYL---WSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490303209 90 LSGAFTLLAVALqatpmlaiAALLAGRVFLGVGESFTATGATLWGIKTVGAIHTSRVISWNGVATYVAMAVGAPLGVTLN 169
Cdd:COG2223 82 IGLLLLALAVSY--------WLLLLLGLLLGIGGGGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLI 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490303209 170 HYFGIS---GFATVVVLVAAIGLLFARTRQDVKVTAGARAPFHSVV-----RKIWPYGLGLAFGTVGFGVIATFITLYFA 241
Cdd:COG2223 154 AAFGWRnafLILGILLLVVAVLAWLFLRDPPAGAAAAAKASLRDQLealrdPRFWLLSLLYFGTFGSFIGFSSWLPPYLV 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490303209 242 AH---SWQGAAFTLSLFSVGFICVRLVLGNTITRFGGVPVSLACFIIESLG-LLLIWLAPSAWMAGVGAFLTGSGFSLVF 317
Cdd:COG2223 234 DQfglSAATAGLLAALFALLGALGRPLGGWLSDRIGGRRVLLIVFALMALGlLLLALALGSLWLFLVLFLLLGLALGGGN 313
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 490303209 318 PALGVEAVKQVEEQNQGTALGTYSAFLDLALGLTGPLAGWV---AGFYDLATLYLLAAIVVALAFLLIFRVHRQQRLVA 393
Cdd:COG2223 314 GAVFALVPDIFPTKNAGAVYGLVGAAGGLGGFLGPLLFGALldaTGSYTAAFLVFAVLALVALVLTLLLYRRPRRAAAA 392
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
17-350 |
3.22e-13 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 70.14 E-value: 3.22e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490303209 17 IVVFTCICYLSIGLPLAVLPGYIHYQLGYSTFVAGIVISLQYISTLISRPHAGRYTDIWGPKKVVSLGIVCCLLSGAFTL 96
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490303209 97 LAValqatpmlAIAALLAGRVFLGVGESFTATGATLWGIKTVGAIHTSRVISWNGVATYVAMAVGAPLGVTLNHYFGISG 176
Cdd:pfam07690 81 FAS--------SLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRA 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490303209 177 ---FATVVVLVAAIGLLFARTRQDVKVTAGARAPFHSVV--------RKIWPYGLGLAFGTVGFGVIATFITLYFAAHSW 245
Cdd:pfam07690 153 aflILAILSLLAAVLLLLPRPPPESKRPKPAEEARLSLIvawkallrDPVLWLLLALLLFGFAFFGLLTYLPLYQEVLGL 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490303209 246 QG--AAFTLSLFSVGFICVRLVLGNTITRFGGVP---VSLACFIIESLGLLLIWLAPSAWMAGVGAFLTGSGFSLVFPAL 320
Cdd:pfam07690 233 SAllAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRrllLALLLLILAALGLLLLSLTLSSLWLLLALLLLGFGFGLVFPAL 312
|
330 340 350
....*....|....*....|....*....|
gi 490303209 321 GVEAVKQVEEQNQGTALGTYSAFLDLALGL 350
Cdd:pfam07690 313 NALVSDLAPKEERGTASGLYNTAGSLGGAL 342
|
|
| MFS_MosC_like |
cd17393 |
Membrane protein MosC and similar proteins of the Major Facilitator Superfamily of ... |
42-385 |
8.72e-12 |
|
Membrane protein MosC and similar proteins of the Major Facilitator Superfamily of transporters; The gene encoding Sinorhizobium meliloti membrane protein MosC is part of the mos locus, which encodes the biosynthesis of the rhizopine 3-O-methyl-scyllo-inosamine. MosC belongs to the bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4 (FucP/MFSD4) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340951 [Multi-domain] Cd Length: 373 Bit Score: 66.13 E-value: 8.72e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490303209 42 QLGYSTFVAGIVISLQYISTLISRPHAGRYTDIWGPKKVVSLGIVCCLLSgaftLLAVALQATPMLAIAALLAGRVFLGV 121
Cdd:cd17393 28 RLGLSDAALGLLLLALGVGALVAMPLAGRLVARFGSRRVTRLGALLLLLA----LLLLGLAPSVPALALALFLFGAANGA 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490303209 122 GE-SFTATGATL---WGIKTVGAIHTsrVISWNGVATYVAMAVGAPLGVTLNHYFGISGFATVVVLVAAIGLLFARTRQD 197
Cdd:cd17393 104 LDvAMNAQGVAVeraYGRPIMSSLHA--MWSLGGLAGALLGAAAIGAGVSPGVHLLAAAVLLLLAALVAIRALLPGTGEA 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490303209 198 VKVTAGARAPFHSVVRKIWPYGLGL--AFGTVGFGVIATFITLYF---AAHSWQGAAFTLSLFSVGFICVRLVLGNTITR 272
Cdd:cd17393 182 AEDRPDGAGKPGFLLPNRLLLLLGLlaLAAALAEGAAADWSALYLrdvLGASAALAALGYAVFSLAMTVGRLFGDRLVDR 261
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490303209 273 FGGVPVSLACFIIESLGLLLIWLAPSAWMAGVGAFLTGSGFSLVFPALgVEAVKQVEEQNQGTALGTYSAFLDLALGLTG 352
Cdd:cd17393 262 FGDVAVLRAGALLAALGLLLALLAPSVWVALAGFALMGLGLSVVVPLA-FSAAGALPGLAAGIAVARVATLGYLGFLVGP 340
|
330 340 350
....*....|....*....|....*....|...
gi 490303209 353 PLAGWVAGFYDLATLYLLAAIVVALAFLLIFRV 385
Cdd:cd17393 341 PLIGFLADATGLRTAFLVVALLALLVALLARAV 373
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
26-385 |
3.78e-11 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 64.13 E-value: 3.78e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490303209 26 LSIGLPLAVLPgYIHYQLGYSTFVAGIVISLQYISTLISRPHAGRYTDIWGPKKVVSLGIVCCLLSGAFTLLAVAlqatp 105
Cdd:cd17474 13 LGVSIVDPILP-AIAEALGASPAQVGLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGGLLCGLSDS----- 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490303209 106 mlaIAALLAGRVFLGVGES-FTATGATLWGiKTVGAIHTSRVISWNGVATYVAMAVGAPLGVTLN--HYFGISGFATVVV 182
Cdd:cd17474 87 ---FALLLAGRALQGIGAAgLGPLALTLIG-DLFEGGERAKAMGLYEAALGLGIAVGPLLGGLLAaiSWRYPFFLLAALI 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490303209 183 LVAAIGLLF----ARTRQDVKVTAGARAPFHSV-VRKIWPYGLGLAFGTVGFGVIATFITLYFAAHSWQGAA---FTLSL 254
Cdd:cd17474 163 PVAFLAILFllpePKEKAKSSSATKLRDLKKALrGRGLLTFLVSAFLYFFLYFAFLTYLPFLLELLYGISPIiigLLFAG 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490303209 255 FSVGFICVRLVLGNTIT-RFGGVPVSLACFIIESLGLLLIWLAPSAWMAGVGAFLTGSGFSLVFPALGVEAVKQVEEQNQ 333
Cdd:cd17474 243 WSVLLALGSLFVGRLLKkRFGARRILVIGLLLYALSLLLLGFVPSLALLLIAIVLFGLGLGLNLPLLTTLVTELAPEEER 322
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|..
gi 490303209 334 GTALGTYSAFLDLALGLTGPLAGWVAGFYDLATLYLLAAIVVALAFLLIFRV 385
Cdd:cd17474 323 GTASSLYNFVRFLGQAVGPLLFGLLLEIFGLSAPFLVGAAIALAAAVLLALL 374
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
26-384 |
3.82e-10 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 60.67 E-value: 3.82e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490303209 26 LSIGLPLAVLPGYI--HYQLGYSTFVAGIVISLQYISTLISRPHAGRYTDIWGPKKVVSLGIVCCLLSgaFTLLAVALqa 103
Cdd:cd17330 10 LGFGIVFPVLPFYVreFNKLGASGYYVGLLQSSYSLGQFLASPLWGRLSDRYGRKPVLLLSLAGSAVS--YVLLGLSR-- 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490303209 104 tpmlAIAALLAGRVFLGVGESFTATGATLWGIKTVGAIHTsRVISWNGVATYVAMAVGAPLGVTLNHYFGISGFATVVVL 183
Cdd:cd17330 86 ----NLWLLFLARFLDGLTGGNVSVAQAYIADITDEEERA-KAFGIISAAFGLGFILGPALGGFLSTPYGYALPFLVAAA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490303209 184 VAAIGLLFARTrqdvkvtagarapFHSVVRKIWPYGLGLAFGTVGFGVIATFITLYFAAHSWQGAAFTLSLFSVGFICVR 263
Cdd:cd17330 161 LALLNLVLVLF-------------FLPPLRRLLLVYFLIALAFAGLESVFSLFLKDRFGFSPSQIGLLLALVGIAGILAQ 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490303209 264 LVLGNTIT-RFGGVPVSLACFIIESLGLLLIWLAPSAWMAGVGAFLTGSGFSLVFPALGVEAVKQVEEQNQGTALGTYSA 342
Cdd:cd17330 228 LLLIPRLAkRLGERKLLRLGLLLAIIGLLLLPFASSVPLLVLAAAILAFGTGIVFPALSALLSKSVPSKEQGKAQGIIQS 307
|
330 340 350 360
....*....|....*....|....*....|....*....|..
gi 490303209 343 FLDLALGLTGPLAGWVAGFYDLATLYLLAAIVVALAFLLIFR 384
Cdd:cd17330 308 LQSLARIIGPLLAGPLYSFLGPGVPFLLAAGLLLIALFLLSL 349
|
|
| MFS_YxlH_like |
cd17490 |
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ... |
43-384 |
5.90e-10 |
|
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341043 [Multi-domain] Cd Length: 371 Bit Score: 60.31 E-value: 5.90e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490303209 43 LGYSTFVAGIVISLQYISTLISRPHAGRYTDIWGPKK-VVSLGIvccLLSGAFTLLAVALQATPMLAIAALLAGrvflgv 121
Cdd:cd17490 26 LGASLSMIGIILGAYGISQMLLRIPLGILSDRIGKRKlFIIIGL---LFTVLASLIMILFPSPWGLLIARFLSG------ 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490303209 122 gesftATGATlWGIKTV------GAIHTSRVISWNGVATYVAMAVGAPLGVTLNHYFGISGFATVVVLVAAIGLLFARTR 195
Cdd:cd17490 97 -----IAAAT-WVSFTVlyasyfPPDEAAKAMGLINLVNNLGQLIAFLIGGLIAEHFGMRAPFLLAALAGVLGFILSLFI 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490303209 196 QDVKVTAGARAPFHSVVRK-------IWPYGLGLAFGTVGFGVIATFITLYfaAHSWQGAAFTLSLFSVGFICV-----R 263
Cdd:cd17490 171 KEERREKKPVLTELKELLSvlkdkklLFFSLLAILQQMITFSTTFGFTPLI--AKQLGASSFQLGLLSIIYLLPnalasL 248
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490303209 264 LVLGNTITRFGGVPVSLACFIIESLGLLLIWLAPSAWMAGVGAFLTGSGFSLVFPALGVEAVKQVEEQNQGTALGTYSAF 343
Cdd:cd17490 249 LSGTLFYKKLGERNTIIIGFLLLGAYCFLIPFAPNLTLLYLLQALNGFGTGILFPLLMSLSIEGVPAEQRSTAMGFFQAI 328
|
330 340 350 360
....*....|....*....|....*....|....*....|...
gi 490303209 344 ldLALGLT-GP-LAGWVAGFYDLATLYLLAAIVVALAFLLIFR 384
Cdd:cd17490 329 --YALGMFlGPvLVGIISEAFGLQTGFFVIGVIALLAAILSLA 369
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
1-383 |
2.37e-09 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 58.73 E-value: 2.37e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490303209 1 MSTSVSTTQLNLRIISIVVFTCICYLSIGLPLAV-----LPGYIHYQLGYSTFVAGIVISLQYISTLISRPHAGRYTDIW 75
Cdd:COG2807 1 MSTTSSSARRSRRAGRWLLLLAIVLVALNLRPAItsvgpLLPEIRADLGLSATQAGLLTTLPLLAFGLFAPLAPRLARRF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490303209 76 GPKKVVSLGIVCCLLSGAFTLLAVAlqatpmlaIAALLAGRVFLGVGESFTATGATLWgIKTVGAIHTSRVISWNGVATY 155
Cdd:COG2807 81 GLERTLLLALLLLAAGLLLRSLAPS--------VALLLAGTALIGAGIAVGNVLLPGL-IKRWFPDRVGLMTGLYTAAMG 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490303209 156 VAMAVGAPLGVTLNHYFGISG----FATVVVLVAAIGLLFARTRQDVKVTAGARAPFHSVVRKIWPYGLGLAFG--TVGF 229
Cdd:COG2807 152 LGAALAAGLTVPLAAALGWRGalavWALLALLALLLWLPLLRRRPAAAAAAPAAASLRSLWRSPLAWLLTLFFGlqSLLY 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490303209 230 GVIATFITLYFAAHSW--QGAAFTLSLFSVGFICVRLVLGNTITRFGGV-PVSLACFIIESLGLLLIWLAPSAWMAgVGA 306
Cdd:COG2807 232 YAVVAWLPPILRDAGLsaATAGLLLSLFQLAGIPGSLLVPLLADRLGDRrPLLLLLGLLGLAGLLGLLLAPGSLPW-LWA 310
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490303209 307 FLTGSGFSLVFPALGVEAVKQVEEQNQGTALGTYSAFLDLALGLTGP-LAGWVA---GFYDLATLYLLAAIVVALAFLLI 382
Cdd:COG2807 311 VLLGLGQGGLFPLALTLIGLRARTPAEAAALSGMAQSVGYLLAALGPlLVGALHdatGSWTAALLLLAALAVLMLVAGLL 390
|
.
gi 490303209 383 F 383
Cdd:COG2807 391 A 391
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
215-385 |
1.07e-08 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 56.14 E-value: 1.07e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490303209 215 IWPYGLGLAFGTVGFGVIATFITLYFAAHSW--QGAAFTLSLFSVGFICVRLVLGNTITRFGGVPVSLACFIIESLGLLL 292
Cdd:COG2814 12 LLALALGAFLSGLGIGIVLPALPLIAADLGAspAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSLL 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490303209 293 IWLAPSAWMAGVGAFLTGSGFSLVFPALGVEAVKQVEEQNQGTALGTYSAFLDLALGLTGPLAGWVAGFYDLATLYLLAA 372
Cdd:COG2814 92 CALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWRWVFLVNA 171
|
170
....*....|...
gi 490303209 373 IVVALAFLLIFRV 385
Cdd:COG2814 172 VLALLALLLLLRL 184
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
43-383 |
1.33e-08 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 56.02 E-value: 1.33e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490303209 43 LGYSTFVAGIVISLQYISTLISRPHAGRYTDIWGPKKVVSLGIVCCLLSGAFTLLAVAlqatpmlaIAALLAGRVFLGVG 122
Cdd:cd17324 29 FGVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALAPS--------FALLLLARALAGLA 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490303209 123 ESFTATGATLWGIKTVGAIHTSRVISWNGVATYVAMAVGAPLGVTLNHYFGISG-FATVVVLVAAIGLLFART------R 195
Cdd:cd17324 101 HGGFWAIAAAYAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLGWRAaFLAIAVLALLAALLLWRLlpslppK 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490303209 196 QDVKVTAGARAPFHSVVRKIWPYGLGLAFGTVGFGVIATFITLYFAA---HSWQGAAFTLSLFSVGFICVRLVLGNTITR 272
Cdd:cd17324 181 KPGSLGLLSSLLLLLRNPRLRLAYLITFLLFGGFFALYTYLAPFLTDvpgFSSSAIIGLLLLFGVAGVVGSPLAGRLADR 260
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490303209 273 FGGVPVSLACFIIESLGLLLIWLAPSAWMAGVGAFLTGSGFSLVFPALGVeAVKQVEEQNQGTALGTYSAFLDLALGLTG 352
Cdd:cd17324 261 GGRRALLIALLLLAAALLLLTLLGPSPLLLLVGLVLWGLGFFAAHSALQT-RVLRLAPEARGLASSLYLAAYNLGGALGA 339
|
330 340 350
....*....|....*....|....*....|.
gi 490303209 353 PLAGWVAGFYDLATLYLLAAIVVALAFLLIF 383
Cdd:cd17324 340 ALGGLVLDHGGWAGVGWVGAALLLLALLLAL 370
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
38-385 |
3.49e-08 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 54.93 E-value: 3.49e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490303209 38 YIHYQLGYSTFVAGIVISLQYISTLISRPHAGRYTDIWGPKKVVSLGivcCLLSGAFTLLAVALQATPMLAIAALLagrv 117
Cdd:cd17329 25 YLHQQLGLSASIVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAG---LLLRALGFALLGFAHSPWLFAIALVL---- 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490303209 118 fLGVGESFTATGATLWGIKTVGAIHTSRVISWNGVATYVAMAVGAPLGVTLNHYFGISGF--ATVVVLVAAIGLLFARTR 195
Cdd:cd17329 98 -TGFGGGLFEPASEAMIADVTTPENRTRAFSLLYWAINLGVAIGPLLGGLLLLYSFRLLFlaAAVLFLLAALVLLFLLPE 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490303209 196 QDVKVTAGARAPFHSVVRKIWPYG--LGLAFGTVGFGVIATFITLYFAAHSWQGAAFTLSLFSVGF-------ICVRLVL 266
Cdd:cd17329 177 TRPKRRAAEKTEILRGYKIVLRDRafLLFLLASFLISLIYFQLESTLPVYVVEILGLGESLLGLLLalnalliVLLQFPV 256
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490303209 267 GNTITRFGGVPVSLACFIIESLGLLLIWLAPSAWMAGVGAFLTGSGFSLVFPALGVEAVKQVEEqnqgTALGTYSAFLDL 346
Cdd:cd17329 257 ARLVERFRLRKILMIGILLFAIGFAVLAFANTLAVLILAMIVLTLGEMLVFPAVQTLVAALAPP----DKRGSYMGFYAL 332
|
330 340 350 360
....*....|....*....|....*....|....*....|....
gi 490303209 347 ALGLTGPLAGWVAGF-----YDLATLYLLAAIVVALAFLLIFRV 385
Cdd:cd17329 333 AWGLGRAIGPLVGGLlldllGPGLPWLILAALGLIAAALLLGLQ 376
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
25-383 |
3.59e-08 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 54.74 E-value: 3.59e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490303209 25 YLSIGLPLAVLPGYIHyQLGYSTFVAGIVISLQYISTLISRPHAGRYTDIWGPKKVVSLGIVCCLLSGAFTLLAVAlqat 104
Cdd:cd06174 9 GLARGLISPLLPALLQ-SFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAFAPS---- 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490303209 105 pmlaIAALLAGRVFLGVGESFTATGATLWGIKTVGAIHTSRVISWNGVATYVAMAVGAPLGVTLNHYFGIS------GFA 178
Cdd:cd06174 84 ----FWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSLGFGwravflIAA 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490303209 179 TVVVLVAAIGLLFARTRQDVKVTAGARAPFHSVV---------RKIWPYGLGLAFGTVGFGVIATFITLYFAAH---SWQ 246
Cdd:cd06174 160 ALALLAAILLLLVVPDPPESARAKNEEASSKSVLkllkrvlknPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLgglSVA 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490303209 247 GAAFTLSLFSVGFICVRLVLGNTITRFGGV-PVSLACFIIESLGLLLIWLAPSAWMAGVGAFLTGSGFSLVFPALGVEAV 325
Cdd:cd06174 240 VAGLLLSLFGLAGALGSLLLGLLSDRLIGRkPLLLIGLLLMALGLALLLLAPSLLLLLLLLLLLGFGLGGLLPLSFALIA 319
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*....
gi 490303209 326 KQVEEQNQGTALGTYSAFLDLALGLTGPLAGWV-AGFYDLATLYLLAAIVVALAFLLIF 383
Cdd:cd06174 320 ELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLlAATFGLTGAFLVLAVLLLLAAILLL 378
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
220-385 |
8.25e-08 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 53.73 E-value: 8.25e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490303209 220 LGLAFGTVGFGVIATFITLYFAAH--SWQGAAFTLSLFSVGFICVRLVLGNTITRFGGVPVSLACFIIESLGLLLIWLAP 297
Cdd:cd17325 3 LALFLDMLGYGIIIPILPLYAESLgaSVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAFAT 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490303209 298 SAWMAGVGAFLTGSGFSLVFPALGVEAVKQVEEQNQGTALGTYSAFLDLALGLTGPLAGWVAGFYDLATLYLLAAIVVAL 377
Cdd:cd17325 83 SYWQLLLARFLQGLASAAVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLVCAALALL 162
|
....*...
gi 490303209 378 AFLLIFRV 385
Cdd:cd17325 163 ALVLALLL 170
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
248-387 |
1.68e-07 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 52.60 E-value: 1.68e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490303209 248 AAFTLSLFSVGFICVRLVLGNTITRFGGVPVSLACFIIESLGLLLIWLAPSAWMAGVGAFLTGSGFSLVFPALGVEAVKQ 327
Cdd:cd17489 33 AGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLLATSVALLLVLRLIHGIGWGAFTTAAATLVADI 112
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|
gi 490303209 328 VEEQNQGTALGTYSAFLDLALGLTGPLAGWVAGFYDLATLYLLAAIVVALAFLLIFRVHR 387
Cdd:cd17489 113 IPPSRRGEGIGYYGLATTLAMALGPALGLFLYQHLGFAVLFIVAAVLALLALLLVFLVKD 172
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
13-193 |
2.16e-07 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 52.58 E-value: 2.16e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490303209 13 RIISIVVFTCICYLSIGLPLAVLPGYIHYQLGYSTFVAGIVISLQYISTLISRPHAGRYTDIWGPKKVVSLGIVccLLSG 92
Cdd:cd17325 200 RLLALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLL--LSAV 277
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490303209 93 AFTLLAVALQATPMLAIAALlagrvfLGVGESFTATGATLWGIKTVGAIHTSRVISWNGVATYVAMAVGAPLGVTLNHYF 172
Cdd:cd17325 278 ALLLLPLATSFWLLLLLLAL------LGLGLGLVFPATLALLADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAF 351
|
170 180
....*....|....*....|....
gi 490303209 173 GISG---FATVVVLVAAIGLLFAR 193
Cdd:cd17325 352 GFATpflAAAALLLLAAVLFLLLR 375
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
68-356 |
8.06e-07 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 50.63 E-value: 8.06e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490303209 68 AGRYTDIWGPKKVVSLGIVCCLLSGAFTLLAVALqatpmlaiAALLAGRVFLGVGESFTATGATLWGIKTVGAIHTSRVI 147
Cdd:cd17321 51 AGRLGDRFGRKRVFLIGLALFGLASLLCALAPSL--------AFLIAARALQGIGAAAIMPASLALIAATFPGERRGRAL 122
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490303209 148 SWNGVATYVAMAVGAPLGVTLNHYFGISGFATVVVLVAAIGLLFARTRQDVKVTAgarapfhsvvrkiwpygLGLAFGTV 227
Cdd:cd17321 123 GLWGAVVGIGAALGPLLGGLLLELFGWRWIFLINVPIGLVALLLARTFSGAVLAA-----------------FLLGAALG 185
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490303209 228 GFGVIATFITLYFAAHSWQGAAFTLSLFSVGFICVRLVLGNTITRFGGVPVSLACFIIESLGLLLIWLAP---SAWMAGV 304
Cdd:cd17321 186 GLLFLLPLYLQGVLGYSPLQAGLALLPLALAMLVAAPLAGRLADRFGPRLVLVAGLLLTAVGLLLLALLGadsSVWLLLP 265
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|..
gi 490303209 305 GAFLTGSGFSLVFPALGVEAVKQVEEQNQGTALGTYSAFLDLALGLTGPLAG 356
Cdd:cd17321 266 GLVLLGLGLGLFATPLTNAALSSVPKEKAGAASGILNTARQLGGALGVALLG 317
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
220-385 |
1.60e-06 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 49.72 E-value: 1.60e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490303209 220 LGLAFGTVGFGVIATFITLYFAAH---SWQGAAFTLSLFSVGFICVRLVLGNTITRFGGVPVSLACFIIESLGLLLIWLA 296
Cdd:pfam07690 3 LAAFLAALGRSLLGPALPLLLAEDlgiSPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLFA 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490303209 297 PSAWMAGVGAFLTGSGFSLVFPALGVEAVKQVEEQNQGTALGTYSAFLDLALGLTGPLAGWVAGFYDLATLYLLAAIVVA 376
Cdd:pfam07690 83 SSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAILSL 162
|
....*....
gi 490303209 377 LAFLLIFRV 385
Cdd:pfam07690 163 LAAVLLLLP 171
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
220-387 |
1.84e-06 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 49.48 E-value: 1.84e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490303209 220 LGLAFGTVGFGVIATFITLYFAAH--SWQGAAFTLSLFSVGFICVRLVLGNTITRFGGVPVSLACFIIESLGLLLIWLAP 297
Cdd:cd17477 3 LSVALLGLGSGLLLPLLSLRLEREgvSTALIGLVASAYYLGILLGSPLVPRLIRRVGHIRAFAAGAAITAVSVLLLALTD 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490303209 298 SAWMAGVGAFLTGSGFSLVFPALGVEAVKQVEEQNQGTALGTYSAFLDLALGLtGPLAGWVAGfYDLATLYLLAAIVVAL 377
Cdd:cd17477 83 SPWVWFLLRFVMGIGLAGLFVVSESWLNALATNENRGRVLGLYSTVLGLGFAL-GPLLLALVG-TAGALPFLIAAVLLLL 160
|
170
....*....|
gi 490303209 378 AFLLIFRVHR 387
Cdd:cd17477 161 ALVPLLLTRR 170
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
33-383 |
2.53e-06 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 49.09 E-value: 2.53e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490303209 33 AVLPgYIHYQLGYSTFVAGIVISLQYISTLISRPHAGRYTDIWGPKKVVSLGIvccLLSGAFTLLAVALQATPMLAIAAL 112
Cdd:cd17478 17 ALLP-LLIAKLGLSYAQAGLLVSVFSITSSLLQPLFGYLADRKPRRYLLPLGP---LLTGLGLSLLGFAPNYWLLLLLVA 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490303209 113 LAGrvfLGVGeSFTATGATLwgIKTVGAIHTSRVISWNGVATYVAMAVGAPLGVTLNHYFGISGFATVVVLVAAIGLLFA 192
Cdd:cd17478 93 LAG---IGSA-AFHPEGARL--ASQAAGGRRGLAMSIFSVGGNLGFALGPLIAAALVALFGGLGLLILLIIPGLAVALLL 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490303209 193 RTRQDVKVTAGARAPFHSV---VRKIWPYGLGLAFGTVGFGVIA-----TFITLYFAAH--SWQGAAFTLSLFSVGFICV 262
Cdd:cd17478 167 LRLRPLKKPEAKKAAAKSSarsTLKGVWRALLLLLIIVFLRSWVlssltTFLPFYLVQRgySLVFAGLLLSLFLFAGAIG 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490303209 263 RLVLGNTITRFGGVPVSLACFIIESLGLLLIWLAPSAWmAGVGAFLTGSGFSLVFPALGVEAVKQVEEqNQGTALGTYSA 342
Cdd:cd17478 247 TLIGGPLSDRFGRRRVIIASLLLAAPFLLLFLLTPGIW-SYILLVLAGFLLFASFPVTVVLAQELLPG-NVGLASGLMMG 324
|
330 340 350 360
....*....|....*....|....*....|....*....|.
gi 490303209 343 FLDLALGLTGPLAGWVAGFYDLATLYLLAAIVVALAFLLIF 383
Cdd:cd17478 325 LSFGLGGIGAPVLGALADAFGLESVLLILALLPLLGALLAF 365
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
220-384 |
2.99e-06 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 48.76 E-value: 2.99e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490303209 220 LGLAFGTVGFGVIATFITLYFAAHSWQGAAFT---LSLFSVGFICVRLVLGNTITRFGGVPVSLACFIIESLGLLLIWLA 296
Cdd:cd17329 6 IGSFLNRLGFFMVWPFMAIYLHQQLGLSASIVglvLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFALLGFA 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490303209 297 PSAWMAGVGAFLTGSGFSLVFPALGVEAVKQVEEQNQGTALGTYSAFLDLALGLTGPLAGWVAGfYDLATLYLLAAIVVA 376
Cdd:cd17329 86 HSPWLFAIALVLTGFGGGLFEPASEAMIADVTTPENRTRAFSLLYWAINLGVAIGPLLGGLLLL-YSFRLLFLAAAVLFL 164
|
....*...
gi 490303209 377 LAFLLIFR 384
Cdd:cd17329 165 LAALVLLF 172
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
26-384 |
3.12e-06 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 49.13 E-value: 3.12e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490303209 26 LSIGLPLAVLPGYIHYQLGYSTFVAGIVISLQYISTLISRPHAGRYTD----IWGPKKVVsLGIVCCLLSGAFTLLAVAL 101
Cdd:COG2211 24 LAFGLLSAYLLYFYTDVLGLSAALVGLILLVARLWDAITDPLIGALSDrtrtRWGRRRPW-ILIGAIPLALSFVLLFTAP 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490303209 102 QATPMLAIAALLAGRVFLGVG-----ESFTATGATLwgikTVGAIHTSRVISWNGVATYVAMAVGAPLGVTLNHYFG--- 173
Cdd:COG2211 103 DLSPTGKLIYALVTYLLLGLAytlvnIPYSALGAEL----TPDYEERTRLSSWRFAFAGLGGLLASVLPPPLVAAFGgda 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490303209 174 ISGFATVVVLVAAIGLLF----ARTRQDVKVTAGARAPFHSVVRKI------WPYGLGLAFGTVGFGVIATFITLYFAAH 243
Cdd:COG2211 179 ALGYRLTALIFAVLGLLAflltFFGTKERPVPEEEKVSLKESLKALlknrpfLLLLLAYLLFFLALALVAALLLYYFKYV 258
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490303209 244 ---SWQGAAFTLSLFSVGFICVRLVLGNTITRFGGVPVSLACFIIESLGLLLIWLAP--SAWMAGVGAFLTGSGFSLVFP 318
Cdd:COG2211 259 lglSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGLLLLFFLGpgNLWLLLVLAALAGIGLGAILV 338
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490303209 319 ---ALGVEAVKQVEEQNQ----GTALGTYSAFLDLALGLTGPLAGWVAGFYD---------------LATLYLLAAIVVA 376
Cdd:COG2211 339 lpwAMLADVVDYDEWKTGrrreGLYFGIFTFAIKLGQALAGALAGLLLALFGyvagaaqspsaltgiRLLFFLLPAVLLL 418
|
....*...
gi 490303209 377 LAFLLIFR 384
Cdd:COG2211 419 LAALLLLF 426
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
10-168 |
9.11e-06 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 47.19 E-value: 9.11e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490303209 10 LNLRIISIVVFT--CICYLSIGL----PLAVLPGYIHYQLGYSTFVAGIVISLQYISTLISRPHAGRYTDIWGPKKVVSL 83
Cdd:cd17503 170 LDLRLFKDRNFTlgLLLSFLLGLglfgAMFLLPLYLQNVLGYSAFESGLVLAPGGLASAILSPLVGRLLDKFGPRLLLLA 249
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490303209 84 GIVCCLLSgaftlLAVALQATPMLAIAALLAGRVFLGVGESFTATGATLWGIKTVGAIHTSRVISWNGVATYVAMAVGAP 163
Cdd:cd17503 250 GLLLLALG-----TLLLAFLTPDTSLWLIILPLFIRGLGMGLVFMPLNTLALNSLPPEQIGDATALFNTIRQLGGSIGTA 324
|
....*
gi 490303209 164 LGVTL 168
Cdd:cd17503 325 LLATL 329
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
248-385 |
1.50e-05 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 46.77 E-value: 1.50e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490303209 248 AAFTLSLFSVGFICVRLVLGNTITRFGGVPVSLACFIIESLGLLLIWLAPSAWMAGVGAFLTGSGFSLVFPALGVEAVKQ 327
Cdd:cd17324 36 AGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALAPSFALLLLARALAGLAHGGFWAIAAAYAADL 115
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*...
gi 490303209 328 VEEQNQGTALGTYSAFLDLALGLTGPLAGWVAGFYDLATLYLLAAIVVALAFLLIFRV 385
Cdd:cd17324 116 VPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLGWRAAFLAIAVLALLAALLLWRL 173
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
42-382 |
2.44e-05 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 46.01 E-value: 2.44e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490303209 42 QLGYSTFVAGIVISLQYISTLISRPHAGRYTDIWGPKKVvslgivccLLSGAFTLLAVALQATPMLAIAALLAGRVFLGV 121
Cdd:cd17477 25 REGVSTALIGLVASAYYLGILLGSPLVPRLIRRVGHIRA--------FAAGAAITAVSVLLLALTDSPWVWFLLRFVMGI 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490303209 122 GESFTATGATLWGIKTVGAIHTSRVISWNGVATYVAMAVGAPLGVTLNHYFGISGFATVVVLVAAIGLLFARTRQDVKVT 201
Cdd:cd17477 97 GLAGLFVVSESWLNALATNENRGRVLGLYSTVLGLGFALGPLLLALVGTAGALPFLIAAVLLLLALVPLLLTRRAAPEIE 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490303209 202 AGARAPFHSVVRKIWPYGLGLAFGTVGFGVIATFITLYFAAH--SWQGAAFTLSLFSVGFICVRLVLGNTITRFGGVPVS 279
Cdd:cd17477 177 EAESISLRRLLRIAPLALLGAFVAGFLEGAFYSLLPLYGLRLglSVAQAALLLAAFVLGGLLLQWPLGWLADRFDRRRVL 256
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490303209 280 LACFIIESLGLLLIWLAPS-AWMAGVGAFLTGSGFSLVFPALGVEAVKQVEEQNQGTALGTYSAFLDLALGLTGPLAGWV 358
Cdd:cd17477 257 LGCALLGALAALLLPLVPGlPLALLVLLFLWGGAAGPLYTLALALAGDRLPGDELVAANAALLLLYGLGSVIGPLLAGAL 336
|
330 340
....*....|....*....|....
gi 490303209 359 AGFYDLATLYLLAAIVVALAFLLI 382
Cdd:cd17477 337 MDAFGPHGLFLFLAAVALLFLLFL 360
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
39-381 |
2.83e-05 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 45.72 E-value: 2.83e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490303209 39 IHYQLGYSTFVAGIVISLQYISTLISRPHAGRYTDIWGPKKVVSLGivCCLLSGAFTLLAVALQATPMLAIAALLagrVF 118
Cdd:cd17355 29 IIAEFGWSRAVISLAFTVGLLAFGLAQPFVGRLLDRFGPRRVMLLG--LLLLAAGLVLLALATSLWQLYLLWGLL---GG 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490303209 119 LGVGESFTATGATLWGIKTvgAIHTSRVISWNGVATYVAMAVGAPLGVTLNHYFGISG----FATVVVLVAAIGLLFART 194
Cdd:cd17355 104 GGAGTLAAVAFATVAAWWF--ERRRGLALGILTAGGGLGSLVFLPLGAALIEAFGWRTallvLALLALLVLVPVLLLLRR 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490303209 195 RQDVKVTAGARAPFHSVVRKIWPYGLG--------LAFGTVGF---GVIATFITLYFAAH-SWQGAAFTLSLFSVGFICV 262
Cdd:cd17355 182 RPADLALRAYDDASPASPGSTLKEALRsasfwllaLAFFLCGFavvGLIVHLVPYLADRGiSPAAAAVALALIGLFNIVG 261
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490303209 263 RLVLGNTITRFGGVPVSLACFIIESLGLLLIWLAPSawmAGVGAFLTGSGFSLVFPALGVEAVKQVEEQNQGTALGTYSA 342
Cdd:cd17355 262 RLLSGWLGDRYSPRRLLAASYALRALGLALLLLLPF---PPLALLLFAALFGLGWGATVPLTAALAARYFGARSYGTLFG 338
|
330 340 350 360
....*....|....*....|....*....|....*....|
gi 490303209 343 FLDLALGLTGPLAGWVAGF-YDLATLYLLAAIVVALAFLL 381
Cdd:cd17355 339 LVFAPHQLGSALGPWLGGLlYDRTGSYTAAWALAVALGLI 378
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
164-383 |
6.70e-05 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 44.46 E-value: 6.70e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490303209 164 LGVTLNHYFGISGFATVVVLVAAIGLLFARtrQDVKVTAGARAPFHSVVRKIWPYGLGLAFGTVGFGVIA----TFITLY 239
Cdd:cd17370 148 LYLLGGNYRTIFLLAAIPALLALLILLFVV--KEYPRPPKLRKKSKKTSLKKLPKAFWLYLLAVALFALGnfsfAFLILR 225
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490303209 240 FAAHSWQGAAFTL--SLFSVGFICVRLVLGNTITRFGGVPVSLACFIIESLGLLLIWLAPSAWMAGVGAFLTGSGFSLVF 317
Cdd:cd17370 226 AQELGLSAALIPLlyALFNLVYALAAYPAGRLSDRIGRKKLLILGYLSLALAYLGFALGSSLWLLLLGFILWGLYMGAQE 305
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 490303209 318 PALGVEAVKQVEEQNQGTALGTYSAFLDLALGLTGPLAGWVAGFYDLATLYLLAAIVVALAFLLIF 383
Cdd:cd17370 306 SIERAAVADLVPAELRGTAYGLFNTVVGIGWLLASLIAGYLWDLISPSAAFLFSAVLALIALLLLL 371
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
244-390 |
2.18e-04 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 42.94 E-value: 2.18e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490303209 244 SWQGAAFTLSLFSVGFICVRLVLGNTITRFGGVPVSLACFIIESLGLLLIWLAPSAWMAGVGAFLTGSGFSLVFPALGVe 323
Cdd:COG2807 51 SATQAGLLTTLPLLAFGLFAPLAPRLARRFGLERTLLLALLLLAAGLLLRSLAPSVALLLAGTALIGAGIAVGNVLLPG- 129
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 490303209 324 AVKQVEEQNQGTALGTYSAFLDLALGLTGPLAGWVAGFYDLATLYLLAAIVVALAFLLIFRVHRQQR 390
Cdd:COG2807 130 LIKRWFPDRVGLMTGLYTAAMGLGAALAAGLTVPLAAALGWRGALAVWALLALLALLLWLPLLRRRP 196
|
|
| MFS_MdtG_MDR_like |
cd17391 |
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ... |
47-192 |
2.24e-04 |
|
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340949 [Multi-domain] Cd Length: 380 Bit Score: 43.02 E-value: 2.24e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490303209 47 TFVAGIVISLQYISTLISRPHAGRYTDIWGPKKVvslgIVCCLLSGAFTLLAVALQATPMlaiaALLAGRVFLGVgesft 126
Cdd:cd17391 239 AFISGLVFSATGVSSLLSAPRLGKLGDRIGHHRI----LLGALLASALLYIPQAFVQTPW----QLGILRFLLGL----- 305
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 490303209 127 ATGATLWGIKTVGAIHT-----SRVISWNGVATYVAMAVGAPLGVTLNHYFGISgfatVVVLVAAIGLLFA 192
Cdd:cd17391 306 ATGGLLPAINSLLAKITpkevaGRIFGYNQSFQYLGNVAGPLLGSAIAAHFGYR----AVFVVTALLVLLN 372
|
|
| MFS_YjiJ |
cd06180 |
Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of ... |
34-385 |
5.41e-04 |
|
Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Escherichia coli YjiJ and other uncharacterized proteins. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340869 [Multi-domain] Cd Length: 371 Bit Score: 41.91 E-value: 5.41e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490303209 34 VLPGYIHyQLGYSTFVAGIVISLQYISTLISRPHAGRYTDIWGPKKVVSLGIVCCLLSgaftLLAVALQATPmlaiAALL 113
Cdd:cd06180 21 LLPLMLA-ELGLSYAQAGWIATANYAGYLVGALLASFLRRRGRARRLIRGGLLLTVLL----LAAMALTSGF----AALL 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490303209 114 AGRVFLGVGESFTATGATLWGIKTVGAIHTSRVISWNGVATYVAMAVGApLGVTLNHYFGIS---GFATVVVLVAAIGLL 190
Cdd:cd06180 92 ALRFLAGAASAFVFVFGSNLVLHHATAAGRGHLIGLLFAGVGLGIALSG-LLVPAGLGGGLSwraGWLALALLSAVLLLL 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490303209 191 FARTRQDVKVTAGARAPFHSVVRKIWPYG-LGLAFGTVGFGVI--ATFITLY---FAAHSWQGAAFtLSLFSVGFICVRL 264
Cdd:cd06180 171 SFLLLRRGPSAPTEASAAESAPGLNRPLWrLALAYGLFGFGYIitATFLPLIareTGAGSLLAGLL-WSLFGLAAVPSCF 249
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490303209 265 VLGNTITRFGGVPVSLACFIIESLGLLLIWLAPSAWMAGVGAFLTGSGFsLVFPALGVEAVKQVEEQNQGTALGTYSAFL 344
Cdd:cd06180 250 LWGALSDRWGTRRALAANLLVQAVGVLLPLLSPGPAGLVLSAVLFGGTF-MAITALVMALARELAPPAAPRALALMTASF 328
|
330 340 350 360
....*....|....*....|....*....|....*....|..
gi 490303209 345 DLALGLTGPLAGWVA-GFYDLATLYLLAAIVVALAFLLIFRV 385
Cdd:cd06180 329 GVGQILGPLLAGWLAdATGGFAPALILAAAALVVAALLALLV 370
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
38-382 |
7.81e-04 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 41.40 E-value: 7.81e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490303209 38 YIHYQLGYSTFVAGIVISLQYISTLISRPHAGRYTDIWGPKKVVslgIVCCLLSGAFTLLAVALQATPMLAIAallagRV 117
Cdd:cd17319 28 TIMKDLGLSPTQYGLIASAFFLGYALFQVPGGWLLDRFGARKVL---AVSMLLWSLFTALTGFATSLTSLYVL-----RF 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490303209 118 FLGVGESFTATGATLWGIKTVGAIHTSRVISWNGVATYVAMAVGAPLGVTLNHYFGISGfatVVVLVAAIGLLFArtrqd 197
Cdd:cd17319 100 LLGVAEAGFFPGAIKALAEWFPARERGRATGLFNSGAPLGAAIGPPLSGWLLLLFGWRW---AFIIEGLLGLLLA----- 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490303209 198 vkvtagarapfhSVVRKIWPYGLGLAFGTVGFGVIATFITLYFAahSWQGAAFTLSLFSVGFICVRLVLGNTITRFGGVP 277
Cdd:cd17319 172 ------------VLWWFYLRQVWGLALGYFGINYALYGLLTWLP--TYLKQARGFSLKQVGLLAAIPFLAGAIGMILGGR 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490303209 278 VS------------LACFIIESLGLLLIWLAPSAWMAGVGAFLTGSGFSLVFPALGVEAVKQVEEQNQGTALGTYSAFLD 345
Cdd:cd17319 238 LSdrllrgarrlviIIGLLLAAVGLLLAYLTTSPVVAVILLSLAGFGIGAASPVFWSLPADLLPGEAAATAGGLINSGGN 317
|
330 340 350
....*....|....*....|....*....|....*..
gi 490303209 346 LALGLTGPLAGWVAGFYDLATLYLLAAIVVALAFLLI 382
Cdd:cd17319 318 LGGFVAPLLIGYLVDATGSYTAAFLFLAAVALLAALL 354
|
|
| MFS_TetA |
cd17388 |
Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily ... |
250-386 |
8.32e-04 |
|
Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of tetracycline resistance proteins similar to Escherichia coli TetA(A), TetA(B), and TetA(E), which are metal-tetracycline/H(+) antiporters that confer resistance to tetracycline by an active tetracycline efflux, which is an energy-dependent process that decreases the accumulation of the antibiotic in cells. TetA-like tetracycline resistance proteins belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340946 [Multi-domain] Cd Length: 385 Bit Score: 41.08 E-value: 8.32e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490303209 250 FTLSLFSVGFICVR-LVLGNTITRFGGVPVSLACFIIESLGLLLIWLAPSAWMAGVGAFLTGSGfSLVFPALGVEAVKQV 328
Cdd:cd17388 246 LSLAVFGLLHALFQaFVTGPIAKRLGEKRAILLGLAADALGFLLLAFATQGWMVFPILILLALG-GIAGPALQGLLSRQV 324
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 490303209 329 EEQNQGTALGTYSAFLDLALGLTGPLAGWV---AGFYDLATLYLLAAIVVALAFLLIFRVH 386
Cdd:cd17388 325 PENEQGELQGVLTSLTSLTSIIGPLLFTGIfaaSPATWPGLAWIIGAALYLICLVLAYRFF 385
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
12-192 |
1.20e-03 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 40.62 E-value: 1.20e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490303209 12 LRIISIVVFTCICYLSIGLPLAVLPGYIHYQLGYSTFVAGIVISLQYISTLISRPHAGRYTDIWGPKKVVSLgIVCCLLS 91
Cdd:COG2271 180 LRFWLLALAYFLVYFALYGFLTWLPTYLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRRKLVL-AIGLLLA 258
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490303209 92 GAFTLLAVALQATPMLAIAALLAGRVFLGVGESFTATGATLWGIKTVGAihtsrVISWNGVATYVAMAVGAPLGVTLNHY 171
Cdd:COG2271 259 ALALLLLALLPSPALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGT-----ASGLVNTFGFLGGALGPLLVGYLLDA 333
|
170 180
....*....|....*....|.
gi 490303209 172 FGISGFATVVVLVAAIGLLFA 192
Cdd:COG2271 334 TGYQAAFLLLAALALLAALLA 354
|
|
| MFS_SLC45_SUC |
cd17313 |
Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily ... |
223-383 |
1.56e-03 |
|
Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily of transporters; This group includes the solute carrier 45 (SLC45) family as well as plant sucrose transporters (SUCs or SUTs) and similar proteins such as Schizosaccharomyces pombe general alpha-glucoside permease. the SLC45 family is composed of four (A1-A4) vertebrate proteins as well as related insect proteins such as Drosophila sucrose transporter SCRT or Slc45-1. Members of this group transport sucrose and other sugars like maltose into the cell, with the concomitant uptake of protons (symport system). Plant sucrose transporters are crucial to carbon partitioning, playing a key role in phloem loading/unloading. They play a key role in loading and unloading of sucrose into the phloem and as a result, they control sucrose distribution throughout the whole plant and drive the osmotic flow system in the phloem. They also play a role in the exchange of sucrose between beneficial symbionts (mycorrhiza and Rhizobium) as well as pathogens such as nematodes and parasitic fungi. There are nine sucrose transporter genes in Arabidopsis and five in rice. Vertebrate SLC45 family proteins have been implicated in the regulation of glucose homoeostasis in the brain (SLC45A1), with skin and hair pigmentation (SLC45A2), and with prostate cancer and myelination (SLC45A3). Mutations in SLC45A2, also called MATP (membrane-associated transporter protein) or melanoma antigen AIM1, cause oculocutaneous albinism type 4 (OCA4), an autosomal recessive disorder of melanin biosynthesis that results in congenital hypopigmentation of ocular and cutaneous tissues. The SLC45 family and related sugar transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340871 [Multi-domain] Cd Length: 421 Bit Score: 40.30 E-value: 1.56e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490303209 223 AFGTVGFGVIATFITLYFAAHSWQG--------------AAFTLSLFSVGFICVRLVLGNTITRFGGVPVSLACFIIESL 288
Cdd:cd17313 244 FFWWIAFFPFELFFTDYMGEEVYHGtsaasshygagvrmGAWGLLIFSLAFLIFSLPIGKLGKKIGRKKVYLIGLVLFAV 323
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490303209 289 GLLLIWLAPSAWMAGVGAFLTGSGFSLVF--PALGVEAVKQVEEQNQGTALGTYSAFLDLALGLTGPLAGWVAGFYDLAT 366
Cdd:cd17313 324 GMALMALVHNVTVALVLFALGGIGWATINinPYPLVSDYHSESGRGQGTDTGLLNLAISLAQILVSLLAGPIIDVKGYGT 403
|
170
....*....|....*..
gi 490303209 367 LYLLAAIVVALAFLLIF 383
Cdd:cd17313 404 VFPVAAVASFLSLVGAL 420
|
|
| MFS_Set |
cd17471 |
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; ... |
42-383 |
1.72e-03 |
|
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; This family is composed of sugar transporters such as Escherichia coli Sugar efflux transporter SetA, SetB, SetC and other sugar transporters. SetA, SetB, and SetC are involved in the efflux of sugars such as lactose, glucose, IPTG, and substituted glucosides or galactosides. They may be involved in the detoxification of non-metabolizable sugar analogs. The Set family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341024 [Multi-domain] Cd Length: 371 Bit Score: 40.22 E-value: 1.72e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490303209 42 QLGYSTFVAGIVISLQYISTLISRPHAGRYTDIWGPKKVVslgIVCCLLSGAFTLLAVALQATPMLAiaaLLAGRVFLGV 121
Cdd:cd17471 26 ELGASPLQIGIFMTLSALSGIVVSQWLGRLSDRGGDRKPL---ILLALLAGALGYLLFAFLRNYWVL---LLVGVVLLSL 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490303209 122 GESFTATGATLW--GIKTVGAIHTSRVISWNGVATYVAMAVGAPLGVTLNHYFGISG-FATVVVLVAAIGLLFARTRQDV 198
Cdd:cd17471 100 GAAAFPQLFALAreYADRSSGRDATLFNSVLRAAFSLAWVIGPPLAFLLLDVLGFTGlFLLAALLYLVVALLVLFLLPSV 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490303209 199 KVTAGARAPFHSVV-----RKIWPYGLGLAFGTVGFGVIATFITLYFAAHSWQGAAFTLSLFSVGFIC---VRLVLGNTI 270
Cdd:cd17471 180 KPPAQKATPASSLVkapvnRRLLLLFAAFTLLFAANSMYIIAMPLYVTNELGGSESWVGLLFGLAAALeipIMLLAGLLA 259
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490303209 271 TRFGGVPVSLACFIIESLGLLLIWLAPSAWMAGVGAFLTGSGFSlVFPALGVEAVKQVEEQNQGTALGTYSAFLDLALGL 350
Cdd:cd17471 260 KRFGKRRLLLAGFLAGVLFYLGLALATSLWQLIALQLLNAIFIG-ITAGLGISYFQDLMPGQPGLATTLYSNASRIGSLL 338
|
330 340 350
....*....|....*....|....*....|...
gi 490303209 351 TGPLAGWVAGFYDLATLYLLAAIVVALAFLLIF 383
Cdd:cd17471 339 GGLLAGVIAQYFGYRAVFLVCAVLALLALVLLL 371
|
|
| MFS_SLC17A9_like |
cd17380 |
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of ... |
21-192 |
1.99e-03 |
|
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily includes solute carrier family 17 member 9 (SLC17A9) and similar proteins including plant inorganic phosphate transporters (PHT4) that are also probably anion transporters. SLC17A9, also called vesicular nucleotide transporter (VNUT), is involved in vesicular storage and exocytosis of ATP. It facilitates the accumulation of ATP and other nucleotides in secretory vesicles such as adrenal chromaffin granules and synaptic vesicles. It also functions as a lysosomal ATP transporter and regulates cell viability. Plant PHT4 family transporters mediate the transport of inorganic phosphate and may also transport organic anions. The Arabidopsis protein AtPHT4;4 is a chloroplast-localized ascorbate transporter. PHT4 proteins show differential expression that suggests specialized functions. The SLC17A9-like subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340938 [Multi-domain] Cd Length: 361 Bit Score: 39.85 E-value: 1.99e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490303209 21 TCICYLS-IGLPLAVLPgyIHYQLGYSTFVAGIVISLQYISTLISRPHAGRYTDIWGPKKVVSLGIvccLLSGAFTLLav 99
Cdd:cd17380 8 TCICYADrVNMPIAIVP--MAKEFGWSKTDQGLVLSSFFWGYALTQVLGGYLADRFGGKKVLLLAV---ALWSLATLL-- 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490303209 100 alqaTPMLA---IAALLAGRVFLGVGESFTATGATLWGIKTVGAIHTSRVISWNGVATYVAMAVGAPLGVTLNHYFGISg 176
Cdd:cd17380 81 ----TPLLAyssLPLLILSRILLGLGEGVHFPSMTSLFSRWVPVSERSRAVSIVTAGSYLGTLLGGLIGPLLLEYYGWP- 155
|
170
....*....|....*.
gi 490303209 177 faTVVVLVAAIGLLFA 192
Cdd:cd17380 156 --SVFYFFGLLGLLWA 169
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
226-385 |
2.20e-03 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 39.87 E-value: 2.20e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490303209 226 TVGFGVIATFITLYFAAHSWQGAA-----FTLSLFSVGFICVRLVLGNTITRFGGVPVSLACFIIESLGLLLIWLAPSAW 300
Cdd:cd17330 9 ALGFGIVFPVLPFYVREFNKLGASgyyvgLLQSSYSLGQFLASPLWGRLSDRYGRKPVLLLSLAGSAVSYVLLGLSRNLW 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490303209 301 MAGVGAFLTGSGFSLVFPALGVEAVkQVEEQNQGTALGTYSAFLDLALGLTGPLAGWVAGFYDLATLYLLAAIVVALAFL 380
Cdd:cd17330 89 LLFLARFLDGLTGGNVSVAQAYIAD-ITDEEERAKAFGIISAAFGLGFILGPALGGFLSTPYGYALPFLVAAALALLNLV 167
|
....*
gi 490303209 381 LIFRV 385
Cdd:cd17330 168 LVLFF 172
|
|
| MFS_FucP_MFSD4_like |
cd17333 |
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ... |
21-383 |
2.55e-03 |
|
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340891 [Multi-domain] Cd Length: 372 Bit Score: 39.61 E-value: 2.55e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490303209 21 TCICYLSIGLP---LAVLPGYIHYQLGYSTFVAGIVISLQYISTLISRPHAGRYTDIWGPKKVVSLGIvCCLLSGAFTLL 97
Cdd:cd17333 1 LYISFFSNGLTdalLGILGPSLEEAFNLNVADVSVIFSSQNAGYLIGSLLAGFLMKRLGRRRTLILGL-LLISLALALIF 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490303209 98 AVALqaTPMLAIAALLAGRVfLGVGESFTATGATLWGIKTVGAIHTSRVISWNGVATYVAMAVGAPLGVTLNHYFG--IS 175
Cdd:cd17333 80 ATPS--IYLFVVLMFLAGLG-AGILDTGANTFVGALFEESSATRLNVLHGFFGLGALIGPLIATSLLTSELSWSWAylII 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490303209 176 GFATVVVLVAAIGLLFARTRQDVKVTAGARAPFHSVVRK-----IWPYGLGLAFGTVGFGVIATFITLYFAAH---SWQG 247
Cdd:cd17333 157 GLIYLLLAILILLTLFPELPSARNPQQSVGAFSASASRLlrnpsIILGALALFLYVGAETAFSSWVPSYLVEKkhvSDGL 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490303209 248 AAFTLSLFSVGFICVRLVLGNTITRFGGVPVSLACFIIESLGLLLIWLAPSAWMAGVGAFLTGSGFSLVFPALGVEAVKQ 327
Cdd:cd17333 237 AGYLLSGFWVGITIGRLLGGPISRRIKPHTLLVLSGSGALLGLLILLLAPTLVVGLVATALLGLFMAALFPTILSLGISN 316
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*.
gi 490303209 328 VEEQnQGTALGTYSAFLDLALGLTGPLAGWVAGFYDLATLYLLAAIVVALAFLLIF 383
Cdd:cd17333 317 LPYA-KGKGTSVLLAAGSIGGAIIPFIMGFIAEAVGIQTAMLLITILYAIIFVLAL 371
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
32-168 |
3.30e-03 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 39.46 E-value: 3.30e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490303209 32 LAVLPGYIHYQLGYSTFVAGIVISLQYISTLISRPHAGRYTDIWGPKKVVSLGIVccLLSGAFTLLAVALQATPMLAIAA 111
Cdd:cd17321 188 LFLLPLYLQGVLGYSPLQAGLALLPLALAMLVAAPLAGRLADRFGPRLVLVAGLL--LTAVGLLLLALLGADSSVWLLLP 265
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*..
gi 490303209 112 LLagrVFLGVGESFTATGATLWGIKTVGAIHTSRVISWNGVATYVAMAVGAPLGVTL 168
Cdd:cd17321 266 GL---VLLGLGLGLFATPLTNAALSSVPKEKAGAASGILNTARQLGGALGVALLGAL 319
|
|
| MFS_MFSD6 |
cd17335 |
Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily ... |
42-387 |
3.53e-03 |
|
Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily domain-containing protein 6 (MFSD6) is also called macrophage MHC class I receptor 2 homolog (MMR2). It has been postulated as a possible receptor for human leukocyte antigen (HLA)-B62. MFSD6 is conserved through evolution and appeared before bilateral animals. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340893 [Multi-domain] Cd Length: 375 Bit Score: 39.10 E-value: 3.53e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490303209 42 QLGYSTFVAGIVISLQYISTLISRPHAGRYTDIWGPKKVVslgIVCCLLSGAFTLLAVALQATPMLAIAALLAgrvflgV 121
Cdd:cd17335 26 QLGLSPTQIGILIGIRPFVRFLSAPLWGALADRFGKRKAL---LLLSLLAAVLFFLSLFFVAQIFWLLLLLVI------L 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490303209 122 GESFTATGATLWGIKTVGAIHTSRV----------ISWNGVATYVAMAVG-APLGVTLNHYFGISGFATVVVLVAAIGLL 190
Cdd:cd17335 97 GAFFSAPVVPLVDSITLQYLGEERErygkqrlwgsIGFGIAALLVGILIDrSSTYKNYTIAFYVFAVLMLLALLLALKFP 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490303209 191 FARTRQDVKVTAGARAPFHSVVRKIWPYGLGLAFGtVGFGVIATFITLYFAAHSWQGAAFTLSLF--SVGFICVRLVLGN 268
Cdd:cd17335 177 FRPKHPEPNENTGGLLALLRNPRVLAFLLVAFLMG-FGHGLIYSFLFWHLQDLGGSKTLIGLLWTvgVVSEIPFFFFSSR 255
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490303209 269 TITRFGGVPVSLACFIIESLGLLLIWLAPSAWMAGVGAFLTGSGFSLVFPALGVEAVKQVEEQNQGTALGTYSA-FLDLA 347
Cdd:cd17335 256 LIQRFGHVGLLYLGLLAYVVRWLLYSFLENPWLVLPIELLHGLTFALVWAAAVSYASAAAPPGLRATAQGLLQGlYFGLG 335
|
330 340 350 360
....*....|....*....|....*....|....*....|
gi 490303209 348 LGLTGPLAGWVAGFYDLATLYLLAAIVVALAFLLIFRVHR 387
Cdd:cd17335 336 GGLGSLIGGYLYEAFGARTTFRFFAIAALAGLLAFFLIQR 375
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
215-395 |
4.35e-03 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 38.95 E-value: 4.35e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490303209 215 IWPYGLGLAFGTVGFGVIATFITLYFAAHSWQgAAFTLSLFSVGFICVRLVLGNTITRFGGVPVSLACFIIESLGLLLIW 294
Cdd:cd06174 1 LLLGFFLTGLARGLISPLLPALLQSFGLSASQ-LGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490303209 295 LAPSAWMAGVGAFLTGSGFSLVFPALGVEAVKQVEEQNQGTALGTYSAFLDLALGLTGPLAGWVAGF--YDLATLYLLAA 372
Cdd:cd06174 80 FAPSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSlgFGWRAVFLIAA 159
|
170 180
....*....|....*....|...
gi 490303209 373 IVVALAFLLIFRVHRQQRLVARE 395
Cdd:cd06174 160 ALALLAAILLLLVVPDPPESARA 182
|
|
| MFS_Azr1_MDR_like |
cd17502 |
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ... |
211-385 |
4.61e-03 |
|
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341045 [Multi-domain] Cd Length: 337 Bit Score: 38.70 E-value: 4.61e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490303209 211 VVRKIWPYGLGLAFGTVGFGVIATFITLYFAA---HSWQGAAFTLSLFSVGFICVRLVLGNTITRFGGV-PVSLACFIIE 286
Cdd:cd17502 165 LLRTILLSSIFGFLFGGALFGLIYYLPLYFQLvlgDSATKSGVRLLPLIIGLVIGSIISGALISKTGRYkPLIVIGTILM 244
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490303209 287 SLGLLLIWLAP---SAWMAGVGAFLTGSGFSLVFPALGVEAVKQVEEQNQGTALGTYSAFLDL--ALGLTgplagwvagf 361
Cdd:cd17502 245 SVGAGLLTTLTldtSKWLLIGYLILLGLGLGIGFQQPLVAVQNAVPPADVGVATATNTFFRSLggTLGVA---------- 314
|
170 180
....*....|....*....|....
gi 490303209 362 ydLATLYLLAAIVVALAFLLIFRV 385
Cdd:cd17502 315 --ITDVFLVALALAALAFLLSLFL 336
|
|
| MFS_YdiM_like |
cd17396 |
Inner membrane transport protein YdiM and similar proteins of the Major Facilitator ... |
45-381 |
5.98e-03 |
|
Inner membrane transport protein YdiM and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily contains Escherichia coli inner membrane transport proteins YdiM and YdiN, which belong to the bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4 (FucP/MFSD4) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340954 [Multi-domain] Cd Length: 384 Bit Score: 38.48 E-value: 5.98e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490303209 45 YSTFVAGI--VISLQYISTLISRPHAGRYTDIWGPKKVVSLGIVCcllsgaFTLLAVALQATPMLAIAALLAgrVFLGVG 122
Cdd:cd17396 30 WHTDVAGVayVISGIGIGRLLTILFAGVLSDKFGRKPSVLLGMVL------YALFFVGILFSPNLIIAYVFA--LLAGAA 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490303209 123 ESFTATGATLWGIKTVGAIHTSRVIswngvATYVAMAVGA---PLGVTL----NHYFGISGFATVVVLVAAIGLL----F 191
Cdd:cd17396 102 NSFLDTGTYPALMEAFPKASGSANI-----LVKAFVSFGQfllPFIIAFlaanNLWYGWSFIVPAAVLVLNALLLlklsF 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490303209 192 ARTRQDVKVTAGARAPFHSVVRKIWPYGLGLafgtVGFGVIATFiTLY------------FAAHSWQGAAFTLSLFSVGF 259
Cdd:cd17396 177 PPQTVTAANTKQKEIPVKREKPKFLIEGIAL----ILIGFTSTA-TFYlfsqwmpkygsaVAGMGEAESLKLISYYSMGS 251
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490303209 260 ICVRLVLGNTITRF-GGVPVSLACFIIESLGLLLIWLAPSAWMAGVGAFLTGSGFSLVFPALGVEAVKQVEEQNQGTALG 338
Cdd:cd17396 252 LVCVFITAVLLKRYvRPIWILVLYPIISLLALFVLYLVPSPDVCILGAFVIGFFAAGGVLQLGLTLMAEFFPKGKGKVTG 331
|
330 340 350 360
....*....|....*....|....*....|....*....|...
gi 490303209 339 TYSAFLDLALGLTGPLAGWVAGFYDLATLYLLAAIVVALAFLL 381
Cdd:cd17396 332 IYMIASSLANFVIPLITGIIASAIGIAYIFLFDFGIALLGLLL 374
|
|
| MFS_YajR_like |
cd17472 |
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux ... |
272-385 |
7.20e-03 |
|
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli inner membrane transport protein YajR and some uncharacterized multidrug-efflux transporters. YajR is a putative proton-driven major facilitator superfamily (MFS) transporter found in many gram-negative bacteria. Unlike most MFS transporters, YajR contains a C-terminal, cytosolic YAM domain, which may play an essential role for the proper functioning of the transporter. YajR-like transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341025 [Multi-domain] Cd Length: 371 Bit Score: 38.35 E-value: 7.20e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490303209 272 RFGGVPVSLACFIIESLGLLLIWLAPSAWMAGVGAFLTGSG-FSLVFPALgveAVKQVEEQNQGTALGTYSAFLDLALGL 350
Cdd:cd17472 58 RIGRKPVILFGLLLFIAGSLLAAYATSIYGLILGRALQGSGaISSVVMAL---LADLTREENRTKAMALIGASIGIAFAI 134
|
90 100 110
....*....|....*....|....*....|....*
gi 490303209 351 TGPLAGWVAGFYDLATLYLLAAIVVALAFLLIFRV 385
Cdd:cd17472 135 SMVLGPLLAAHLGVSGLFLITAILSLVSLLILLFF 169
|
|
| |
