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Conserved domains on  [gi|490299905|ref|WP_004195314|]
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MULTISPECIES: class I SAM-dependent methyltransferase [Burkholderia]

Protein Classification

class I SAM-dependent methyltransferase( domain architecture ID 10789277)

class I SAM-dependent methyltransferase is an enzyme that uses S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyl transfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)

CATH:  2.20.25.110
EC:  2.1.1.-
Gene Ontology:  GO:0008168|GO:1904047
PubMed:  12826405
SCOP:  3000118

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
UbiE COG2226
Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; ...
 12-162 6.51e-26

Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG is part of the Pathway/BioSystem: Biotin biosynthesis


:

Pssm-ID: 441828 [Multi-domain]  Cd Length: 143  Bit Score: 97.76  E-value: 6.51e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490299905  12 YDRFAnealAPWDalFIARIRELARALPPGTLADIGTATAVVPVRLAAdpamAQWRFVGVDLDPAMLDEGVPRIARLGLa 91
Cdd:COG2226    1 FDRVA----ARYD--GREALLAALGLRPGARVLDLGCGTGRLALALAE----RGARVTGVDISPEMLELARERAAEAGL- 69

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 490299905  92 gRVALKVGDALALPFDDASLSMVVSRATLHHLPDKALSLAEMFRVLRPGGVGVVHDMRRDAPPALLERFTQ 162
Cdd:COG2226   70 -NVEFVVGDAEDLPFPDGSFDLVISSFVLHHLPDPERALAEIARVLKPGGRLVVVDFSPPDLAELEELLAE 139
 
Name Accession Description Interval E-value
UbiE COG2226
Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; ...
 12-162 6.51e-26

Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG is part of the Pathway/BioSystem: Biotin biosynthesis


Pssm-ID: 441828 [Multi-domain]  Cd Length: 143  Bit Score: 97.76  E-value: 6.51e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490299905  12 YDRFAnealAPWDalFIARIRELARALPPGTLADIGTATAVVPVRLAAdpamAQWRFVGVDLDPAMLDEGVPRIARLGLa 91
Cdd:COG2226    1 FDRVA----ARYD--GREALLAALGLRPGARVLDLGCGTGRLALALAE----RGARVTGVDISPEMLELARERAAEAGL- 69

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 490299905  92 gRVALKVGDALALPFDDASLSMVVSRATLHHLPDKALSLAEMFRVLRPGGVGVVHDMRRDAPPALLERFTQ 162
Cdd:COG2226   70 -NVEFVVGDAEDLPFPDGSFDLVISSFVLHHLPDPERALAEIARVLKPGGRLVVVDFSPPDLAELEELLAE 139
Methyltransf_25 pfam13649
Methyltransferase domain; This family appears to be a methyltransferase domain.
 45-141 1.16e-20

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 463945 [Multi-domain]  Cd Length: 96  Bit Score: 82.61  E-value: 1.16e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490299905   45 DIGTATAVVPVRLAAdpaMAQWRFVGVDLDPAMLDEGVPRIARLGLagRVALKVGDALALPFDDASLSMVVSRATLHHLP 124
Cdd:pfam13649   3 DLGCGTGRLTLALAR---RGGARVTGVDLSPEMLERARERAAEAGL--NVEFVQGDAEDLPFPDGSFDLVVSSGVLHHLP 77

                          90
                  ....*....|....*....
gi 490299905  125 DKALS--LAEMFRVLRPGG 141
Cdd:pfam13649  78 DPDLEaaLREIARVLKPGG 96
PRK08317 PRK08317
hypothetical protein; Provisional
 27-147 8.96e-17

hypothetical protein; Provisional


Pssm-ID: 181382 [Multi-domain]  Cd Length: 241  Bit Score: 76.13  E-value: 8.96e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490299905  27 FIARIRELARAL----PPGTLADIGTATAVVpVRLAADPAMAQWRFVGVDLDPAMLDEGVPRIArlGLAGRVALKVGDAL 102
Cdd:PRK08317   3 DFRRYRARTFELlavqPGDRVLDVGCGPGND-ARELARRVGPEGRVVGIDRSEAMLALAKERAA--GLGPNVEFVRGDAD 79

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 490299905 103 ALPFDDASLSMVVSRATLHHLPDKALSLAEMFRVLRPGGVGVVHD 147
Cdd:PRK08317  80 GLPFPDGSFDAVRSDRVLQHLEDPARALAEIARVLRPGGRVVVLD 124
MenG_MenH_UbiE TIGR01934
ubiquinone/menaquinone biosynthesis methyltransferases; This model represents a family of ...
 9-145 5.18e-15

ubiquinone/menaquinone biosynthesis methyltransferases; This model represents a family of methyltransferases involved in the biosynthesis of menaquinone and ubiqinone. Some members such as the UbiE enzyme from E. coli are believed to act in both pathways, while others may act in only the menaquinone pathway. These methyltransferases are members of the UbiE/CoQ family of methyltransferases (pfam01209) which also contains ubiquinone methyltransferases and other methyltransferases. Members of this clade include a wide distribution of bacteria and eukaryotes, but no archaea. An outgroup for this clade is provided by the phosphatidylethanolamine methyltransferase (EC 2.1.1.17) from Rhodobacter sphaeroides. Note that a number of non-orthologous genes which are members of pfam03737 have been erroneously annotated as MenG methyltransferases. [Biosynthesis of cofactors, prosthetic groups, and carriers, Menaquinone and ubiquinone]


Pssm-ID: 273884 [Multi-domain]  Cd Length: 223  Bit Score: 71.14  E-value: 5.18e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490299905    9 ADDYDRfANEALA-PWDALFIARIRELARALPPGTLADIGTATAVVPVRLAADPAMAQWrFVGVDLDPAMLDEGvprIAR 87
Cdd:TIGR01934   9 APKYDL-LNDLLSfGLHRLWRRRAVKLIGVFKGQKVLDVACGTGDLAIELAKSAPDRGK-VTGVDFSSEMLEVA---KKK 83

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 490299905   88 LGLAGRVALKVGDALALPFDDASLSMVVSRATLHHLPDKALSLAEMFRVLRPGGVGVV 145
Cdd:TIGR01934  84 SELPLNIEFIQADAEALPFEDNSFDAVTIAFGLRNVTDIQKALREMYRVLKPGGRLVI 141
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 42-146 2.81e-10

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 55.51  E-value: 2.81e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490299905  42 TLADIGTATAVVPVRLAADPAmaqWRFVGVDLDPAMLDEGVpRIARLGLAGRVALKVGDALALPFD-DASLSMVVSRATL 120
Cdd:cd02440    1 RVLDLGCGTGALALALASGPG---ARVTGVDISPVALELAR-KAAAALLADNVEVLKGDAEELPPEaDESFDVIISDPPL 76

                         90       100
                 ....*....|....*....|....*..
gi 490299905 121 HHLPDKALS-LAEMFRVLRPGGVGVVH 146
Cdd:cd02440   77 HHLVEDLARfLEEARRLLKPGGVLVLT 103
 
Name Accession Description Interval E-value
UbiE COG2226
Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; ...
 12-162 6.51e-26

Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG is part of the Pathway/BioSystem: Biotin biosynthesis


Pssm-ID: 441828 [Multi-domain]  Cd Length: 143  Bit Score: 97.76  E-value: 6.51e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490299905  12 YDRFAnealAPWDalFIARIRELARALPPGTLADIGTATAVVPVRLAAdpamAQWRFVGVDLDPAMLDEGVPRIARLGLa 91
Cdd:COG2226    1 FDRVA----ARYD--GREALLAALGLRPGARVLDLGCGTGRLALALAE----RGARVTGVDISPEMLELARERAAEAGL- 69

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 490299905  92 gRVALKVGDALALPFDDASLSMVVSRATLHHLPDKALSLAEMFRVLRPGGVGVVHDMRRDAPPALLERFTQ 162
Cdd:COG2226   70 -NVEFVVGDAEDLPFPDGSFDLVISSFVLHHLPDPERALAEIARVLKPGGRLVVVDFSPPDLAELEELLAE 139
Methyltransf_25 pfam13649
Methyltransferase domain; This family appears to be a methyltransferase domain.
 45-141 1.16e-20

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 463945 [Multi-domain]  Cd Length: 96  Bit Score: 82.61  E-value: 1.16e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490299905   45 DIGTATAVVPVRLAAdpaMAQWRFVGVDLDPAMLDEGVPRIARLGLagRVALKVGDALALPFDDASLSMVVSRATLHHLP 124
Cdd:pfam13649   3 DLGCGTGRLTLALAR---RGGARVTGVDLSPEMLERARERAAEAGL--NVEFVQGDAEDLPFPDGSFDLVVSSGVLHHLP 77

                          90
                  ....*....|....*....
gi 490299905  125 DKALS--LAEMFRVLRPGG 141
Cdd:pfam13649  78 DPDLEaaLREIARVLKPGG 96
PRK08317 PRK08317
hypothetical protein; Provisional
 27-147 8.96e-17

hypothetical protein; Provisional


Pssm-ID: 181382 [Multi-domain]  Cd Length: 241  Bit Score: 76.13  E-value: 8.96e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490299905  27 FIARIRELARAL----PPGTLADIGTATAVVpVRLAADPAMAQWRFVGVDLDPAMLDEGVPRIArlGLAGRVALKVGDAL 102
Cdd:PRK08317   3 DFRRYRARTFELlavqPGDRVLDVGCGPGND-ARELARRVGPEGRVVGIDRSEAMLALAKERAA--GLGPNVEFVRGDAD 79

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 490299905 103 ALPFDDASLSMVVSRATLHHLPDKALSLAEMFRVLRPGGVGVVHD 147
Cdd:PRK08317  80 GLPFPDGSFDAVRSDRVLQHLEDPARALAEIARVLRPGGRVVVLD 124
Methyltransf_11 pfam08241
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
 45-145 1.27e-16

Methyltransferase domain; Members of this family are SAM dependent methyltransferases.


Pssm-ID: 462406 [Multi-domain]  Cd Length: 94  Bit Score: 71.93  E-value: 1.27e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490299905   45 DIGTATAVVPVRLAADPAmaqwRFVGVDLDPAMLDEGVPRIARLGLAGRValkvGDALALPFDDASLSMVVSRATLHHLP 124
Cdd:pfam08241   2 DVGCGTGLLTELLARLGA----RVTGVDISPEMLELAREKAPREGLTFVV----GDAEDLPFPDNSFDLVLSSEVLHHVE 73

                          90       100
                  ....*....|....*....|.
gi 490299905  125 DKALSLAEMFRVLRPGGVGVV 145
Cdd:pfam08241  74 DPERALREIARVLKPGGILII 94
MenG_MenH_UbiE TIGR01934
ubiquinone/menaquinone biosynthesis methyltransferases; This model represents a family of ...
 9-145 5.18e-15

ubiquinone/menaquinone biosynthesis methyltransferases; This model represents a family of methyltransferases involved in the biosynthesis of menaquinone and ubiqinone. Some members such as the UbiE enzyme from E. coli are believed to act in both pathways, while others may act in only the menaquinone pathway. These methyltransferases are members of the UbiE/CoQ family of methyltransferases (pfam01209) which also contains ubiquinone methyltransferases and other methyltransferases. Members of this clade include a wide distribution of bacteria and eukaryotes, but no archaea. An outgroup for this clade is provided by the phosphatidylethanolamine methyltransferase (EC 2.1.1.17) from Rhodobacter sphaeroides. Note that a number of non-orthologous genes which are members of pfam03737 have been erroneously annotated as MenG methyltransferases. [Biosynthesis of cofactors, prosthetic groups, and carriers, Menaquinone and ubiquinone]


Pssm-ID: 273884 [Multi-domain]  Cd Length: 223  Bit Score: 71.14  E-value: 5.18e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490299905    9 ADDYDRfANEALA-PWDALFIARIRELARALPPGTLADIGTATAVVPVRLAADPAMAQWrFVGVDLDPAMLDEGvprIAR 87
Cdd:TIGR01934   9 APKYDL-LNDLLSfGLHRLWRRRAVKLIGVFKGQKVLDVACGTGDLAIELAKSAPDRGK-VTGVDFSSEMLEVA---KKK 83

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 490299905   88 LGLAGRVALKVGDALALPFDDASLSMVVSRATLHHLPDKALSLAEMFRVLRPGGVGVV 145
Cdd:TIGR01934  84 SELPLNIEFIQADAEALPFEDNSFDAVTIAFGLRNVTDIQKALREMYRVLKPGGRLVI 141
UbiG COG2227
2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and ...
 16-145 7.04e-15

2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and metabolism]; 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase is part of the Pathway/BioSystem: Ubiquinone biosynthesis


Pssm-ID: 441829 [Multi-domain]  Cd Length: 126  Bit Score: 68.51  E-value: 7.04e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490299905  16 ANEALAPWDALFIARIRELAraLPPGTLADIGTATAVVPVRLAAdpamAQWRFVGVDLDPAMLDEGVPRIARLglagRVA 95
Cdd:COG2227    3 DPDARDFWDRRLAALLARLL--PAGGRVLDVGCGTGRLALALAR----RGADVTGVDISPEALEIARERAAEL----NVD 72

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 490299905  96 LKVGDALALPFDDASLSMVVSRATLHHLPDKALSLAEMFRVLRPGGVGVV 145
Cdd:COG2227   73 FVQGDLEDLPLEDGSFDLVICSEVLEHLPDPAALLRELARLLKPGGLLLL 122
Methyltransf_31 pfam13847
Methyltransferase domain; This family appears to have methyltransferase activity.
 45-191 4.73e-14

Methyltransferase domain; This family appears to have methyltransferase activity.


Pssm-ID: 463998 [Multi-domain]  Cd Length: 150  Bit Score: 67.06  E-value: 4.73e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490299905   45 DIGTATAVVpVRLAADPAMAQWRFVGVDLDPAMLDEGVPRIARLGLAgRVALKVGDALALP--FDDASLSMVVSRATLHH 122
Cdd:pfam13847   9 DLGCGTGHL-SFELAEELGPNAEVVGIDISEEAIEKARENAQKLGFD-NVEFEQGDIEELPelLEDDKFDVVISNCVLNH 86

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 490299905  123 LPDKALSLAEMFRVLRPGGVGVVHDMRRDAppALLERFTQMRAAANYPPTHLEEKvtlDEARELVAAAG 191
Cdd:pfam13847  87 IPDPDKVLQEILRVLKPGGRLIISDPDSLA--ELPAHVKEDSTYYAGCVGGAILK---KKLYELLEEAG 150
SmtA COG0500
SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, ...
 12-196 9.42e-14

SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, General function prediction only];


Pssm-ID: 440266 [Multi-domain]  Cd Length: 199  Bit Score: 67.25  E-value: 9.42e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490299905  12 YDRFANEALAPWDALFIARIRELARalpPGTLADIGTATAVVPVRLAAdpaMAQWRFVGVDLDPAMLDEGVPRIARLGLa 91
Cdd:COG0500    2 WDSYYSDELLPGLAALLALLERLPK---GGRVLDLGCGTGRNLLALAA---RFGGRVIGIDLSPEAIALARARAAKAGL- 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490299905  92 GRVALKVGDALAL-PFDDASLSMVVSRATLHHLPDKALS--LAEMFRVLRPGGVGVVhDMRRDAPPALLERFTQMRAAAN 168
Cdd:COG0500   75 GNVEFLVADLAELdPLPAESFDLVVAFGVLHHLPPEEREalLRELARALKPGGVLLL-SASDAAAALSLARLLLLATASL 153

                        170       180
                 ....*....|....*....|....*...
gi 490299905 169 YPPTHLEEKVTLDEARELVAAAGLAEHA 196
Cdd:COG0500  154 LELLLLLRLLALELYLRALLAAAATEDL 181
Cfa COG2230
Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport ...
 29-147 4.59e-13

Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport and metabolism];


Pssm-ID: 441831 [Multi-domain]  Cd Length: 158  Bit Score: 64.57  E-value: 4.59e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490299905  29 ARIRELARAL--PPG-TLADIGTATAVVPVRLAAdpaMAQWRFVGVDLDPAMLDEGVPRIARLGLAGRVALKVGDALALP 105
Cdd:COG2230   38 AKLDLILRKLglKPGmRVLDIGCGWGGLALYLAR---RYGVRVTGVTLSPEQLEYARERAAEAGLADRVEVRLADYRDLP 114

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 490299905 106 FD---DAslsmVVSRATLHHLPDKALS--LAEMFRVLRPGGVGVVHD 147
Cdd:COG2230  115 ADgqfDA----IVSIGMFEHVGPENYPayFAKVARLLKPGGRLLLHT 157
ubiE PRK00216
bifunctional demethylmenaquinone methyltransferase/2-methoxy-6-polyprenyl-1,4-benzoquinol ...
 32-145 4.78e-13

bifunctional demethylmenaquinone methyltransferase/2-methoxy-6-polyprenyl-1,4-benzoquinol methylase UbiE;


Pssm-ID: 234689 [Multi-domain]  Cd Length: 239  Bit Score: 65.94  E-value: 4.78e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490299905  32 RELARALPPGTLADIGTATAVVPVRLAADpAMAQWRFVGVDLDPAMLDEGVPRIARLGLAGRVALKVGDALALPFDDASl 111
Cdd:PRK00216  44 IKWLGVRPGDKVLDLACGTGDLAIALAKA-VGKTGEVVGLDFSEGMLAVGREKLRDLGLSGNVEFVQGDAEALPFPDNS- 121

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 490299905 112 smvVSRAT----LHHLPDKALSLAEMFRVLRPGGVGVV 145
Cdd:PRK00216 122 ---FDAVTiafgLRNVPDIDKALREMYRVLKPGGRLVI 156
Tam COG4106
Trans-aconitate methyltransferase [Energy production and conversion];
39-142 6.39e-13

Trans-aconitate methyltransferase [Energy production and conversion];


Pssm-ID: 443282 [Multi-domain]  Cd Length: 100  Bit Score: 62.53  E-value: 6.39e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490299905  39 PPGTLADIGTATAVVPVRLAAdpAMAQWRFVGVDLDPAMLDEgvpriARlGLAGRVALKVGDALALPFDdASLSMVVSRA 118
Cdd:COG4106    1 PPRRVLDLGCGTGRLTALLAE--RFPGARVTGVDLSPEMLAR-----AR-ARLPNVRFVVADLRDLDPP-EPFDLVVSNA 71

                         90       100
                 ....*....|....*....|....
gi 490299905 119 TLHHLPDKALSLAEMFRVLRPGGV 142
Cdd:COG4106   72 ALHWLPDHAALLARLAAALAPGGV 95
Ubie_methyltran pfam01209
ubiE/COQ5 methyltransferase family;
38-145 5.33e-12

ubiE/COQ5 methyltransferase family;


Pssm-ID: 395966 [Multi-domain]  Cd Length: 228  Bit Score: 62.84  E-value: 5.33e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490299905   38 LPPGTLADIGTATAVVPVRLAaDPAMAQWRFVGVDLDPAMLDEGVPRIARLGLAgRVALKVGDALALPFDDASLSMVVSR 117
Cdd:pfam01209  41 KRGNKFLDVAGGTGDWTFGLS-DSAGSSGKVVGLDINENMLKEGEKKAKEEGKY-NIEFLQGNAEELPFEDDSFDIVTIS 118

                          90       100
                  ....*....|....*....|....*...
gi 490299905  118 ATLHHLPDKALSLAEMFRVLRPGGVGVV 145
Cdd:pfam01209 119 FGLRNFPDYLKVLKEAFRVLKPGGRVVC 146
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 42-146 2.81e-10

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 55.51  E-value: 2.81e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490299905  42 TLADIGTATAVVPVRLAADPAmaqWRFVGVDLDPAMLDEGVpRIARLGLAGRVALKVGDALALPFD-DASLSMVVSRATL 120
Cdd:cd02440    1 RVLDLGCGTGALALALASGPG---ARVTGVDISPVALELAR-KAAAALLADNVEVLKGDAEELPPEaDESFDVIISDPPL 76

                         90       100
                 ....*....|....*....|....*..
gi 490299905 121 HHLPDKALS-LAEMFRVLRPGGVGVVH 146
Cdd:cd02440   77 HHLVEDLARfLEEARRLLKPGGVLVLT 103
Methyltransf_12 pfam08242
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
 45-142 3.21e-10

Methyltransferase domain; Members of this family are SAM dependent methyltransferases.


Pssm-ID: 400515 [Multi-domain]  Cd Length: 98  Bit Score: 55.07  E-value: 3.21e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490299905   45 DIGTATAVVPVRLAadPAMAQWRFVGVDLDPAMLDEGVPRIARLGLAGRVALKVGDALALPFDDASLSMVVSRATLHHLP 124
Cdd:pfam08242   2 EIGCGTGTLLRALL--EALPGLEYTGLDISPAALEAARERLAALGLLNAVRVELFQLDLGELDPGSFDVVVASNVLHHLA 79

                          90
                  ....*....|....*...
gi 490299905  125 DKALSLAEMFRVLRPGGV 142
Cdd:pfam08242  80 DPRAVLRNIRRLLKPGGV 97
PLN02244 PLN02244
tocopherol O-methyltransferase
 70-141 5.27e-10

tocopherol O-methyltransferase


Pssm-ID: 215135 [Multi-domain]  Cd Length: 340  Bit Score: 58.22  E-value: 5.27e-10
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 490299905  70 GVDLDPAMLDEGVPRIARLGLAGRVALKVGDALALPFDDASLSMVVSRATLHHLPDKALSLAEMFRVLRPGG 141
Cdd:PLN02244 146 GITLSPVQAARANALAAAQGLSDKVSFQVADALNQPFEDGQFDLVWSMESGEHMPDKRKFVQELARVAAPGG 217
arsM PRK11873
arsenite methyltransferase;
70-156 1.23e-08

arsenite methyltransferase;


Pssm-ID: 237007 [Multi-domain]  Cd Length: 272  Bit Score: 53.80  E-value: 1.23e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490299905  70 GVDLDPAMLdEGVPRIARLGLAGRVALKVGDALALPFDDASLSMVVSRATLHHLPDKALSLAEMFRVLRPGGVGVVHDM- 148
Cdd:PRK11873 107 GVDMTPEML-AKARANARKAGYTNVEFRLGEIEALPVADNSVDVIISNCVINLSPDKERVFKEAFRVLKPGGRFAISDVv 185


                 ....*....
gi 490299905 149 -RRDAPPAL 156
Cdd:PRK11873 186 lRGELPEEI 194
COG4976 COG4976
Predicted methyltransferase, contains TPR repeat [General function prediction only];
9-142 1.54e-08

Predicted methyltransferase, contains TPR repeat [General function prediction only];


Pssm-ID: 444001 [Multi-domain]  Cd Length: 181  Bit Score: 52.31  E-value: 1.54e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490299905   9 ADDYDRFANEALA-PWDALFIARIRELARALPPGTLADIGTATAVVPVRLAAdpamAQWRFVGVDLDPAMLDegvprIAR 87
Cdd:COG4976   15 ADSYDAALVEDLGyEAPALLAEELLARLPPGPFGRVLDLGCGTGLLGEALRP----RGYRLTGVDLSEEMLA-----KAR 85

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 490299905  88 lGLAGRVALKVGDALALPFDDASLSMVVSRATLHHLPDKALSLAEMFRVLRPGGV 142
Cdd:COG4976   86 -EKGVYDRLLVADLADLAEPDGRFDLIVAADVLTYLGDLAAVFAGVARALKPGGL 139
Trm11 COG1041
tRNA G10 N-methylase Trm11 [Translation, ribosomal structure and biogenesis]; tRNA G10 ...
 19-162 2.76e-06

tRNA G10 N-methylase Trm11 [Translation, ribosomal structure and biogenesis]; tRNA G10 N-methylase Trm11 is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 440663 [Multi-domain]  Cd Length: 172  Bit Score: 46.10  E-value: 2.76e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490299905  19 ALAPWDALFIARireLARALPPGTLAD--IGTATAVVPVRLAAdpamaqWRFVGVDLDPAMLDEGVPRIARLGLAgRVAL 96
Cdd:COG1041    9 SLDPRLARALVN---LAGAKEGDTVLDpfCGTGTILIEAGLLG------RRVIGSDIDPKMVEGARENLEHYGYE-DADV 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490299905  97 KVGDALALPFDDASLSMVV-----------SRATLHHLPDKALSlaEMFRVLRPGGVGVV---HDMRRDAPPA---LLER 159
Cdd:COG1041   79 IRGDARDLPLADESVDAIVtdppygrsskiSGEELLELYEKALE--EAARVLKPGGRVVIvtpRDIDELLEEAgfkVLER 156


                 ...
gi 490299905 160 FTQ 162
Cdd:COG1041  157 HEQ 159
COG4627 COG4627
Predicted SAM-depedendent methyltransferase [General function prediction only];
98-142 5.37e-06

Predicted SAM-depedendent methyltransferase [General function prediction only];


Pssm-ID: 443666 [Multi-domain]  Cd Length: 161  Bit Score: 44.86  E-value: 5.37e-06
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*...
gi 490299905  98 VGDAL-ALPFDDASLSMVVSRATLHHLPDKALS--LAEMFRVLRPGGV 142
Cdd:COG4627   33 VGDLTdPLPFPDNSVDAIYSSHVLEHLDYEEAPlaLKECYRVLKPGGI 80
TrmN6 COG4123
tRNA1(Val) A37 N6-methylase TrmN6 [Translation, ribosomal structure and biogenesis]; tRNA1(Val) ...
 24-169 6.91e-06

tRNA1(Val) A37 N6-methylase TrmN6 [Translation, ribosomal structure and biogenesis]; tRNA1(Val) A37 N6-methylase TrmN6 is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 443299 [Multi-domain]  Cd Length: 238  Bit Score: 45.52  E-value: 6.91e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490299905  24 DALFIARireLARALPPGTLADIGTATAVVPVRLAADPAMAqwRFVGVDLDPAMLDEGVPRIARLGLAGRVALKVGDALA 103
Cdd:COG4123   25 DAVLLAA---FAPVKKGGRVLDLGTGTGVIALMLAQRSPGA--RITGVEIQPEAAELARRNVALNGLEDRITVIHGDLKE 99

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490299905 104 LP--FDDASLSMVVS-----------------RATLHHLPDkaLSLAEMFRV----LRPGG-VGVVHdmrrdaPPALLER 159
Cdd:COG4123  100 FAaeLPPGSFDLVVSnppyfkagsgrkspdeaRAIARHEDA--LTLEDLIRAaarlLKPGGrFALIH------PAERLAE 171

                        170
                 ....*....|
gi 490299905 160 FtqMRAAANY 169
Cdd:COG4123  172 I--LAALRKY 179
Methyltransf_23 pfam13489
Methyltransferase domain; This family appears to be a methyltransferase domain.
 12-193 3.10e-05

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 404385 [Multi-domain]  Cd Length: 162  Bit Score: 42.80  E-value: 3.10e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490299905   12 YDRFANEALAPWdalfiaRIRELARALPPGTLADIGTATAVVPVRLAAdpamAQWRFVGVDLDPAMlDEGVPRIARLGLA 91
Cdd:pfam13489   1 YAHQRERLLADL------LLRLLPKLPSPGRVLDFGCGTGIFLRLLRA----QGFSVTGVDPSPIA-IERALLNVRFDQF 69

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490299905   92 GRVALkvgDALALPFDdaslsMVVSRATLHHLPDKALSLAEMFRVLRPGGVGVVHDmrRDAPPALLERFTQMRAAANYpP 171
Cdd:pfam13489  70 DEQEA---AVPAGKFD-----VIVAREVLEHVPDPPALLRQIAALLKPGGLLLLST--PLASDEADRLLLEWPYLRPR-N 138

                         170       180
                  ....*....|....*....|..
gi 490299905  172 THLeEKVTLDEARELVAAAGLA 193
Cdd:pfam13489 139 GHI-SLFSARSLKRLLEEAGFE 159
PLN02233 PLN02233
ubiquinone biosynthesis methyltransferase
 99-154 4.03e-05

ubiquinone biosynthesis methyltransferase


Pssm-ID: 177877 [Multi-domain]  Cd Length: 261  Bit Score: 43.34  E-value: 4.03e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 490299905  99 GDALALPFDDASLSMVVSRATLHHLPDKALSLAEMFRVLRPGGVGVVHDMRRDAPP 154
Cdd:PLN02233 134 GDATDLPFDDCYFDAITMGYGLRNVVDRLKAMQEMYRVLKPGSRVSILDFNKSTQP 189
TrmR COG4122
tRNA 5-hydroxyU34 O-methylase TrmR/YrrM [Translation, ribosomal structure and biogenesis]; ...
 31-166 4.64e-05

tRNA 5-hydroxyU34 O-methylase TrmR/YrrM [Translation, ribosomal structure and biogenesis]; tRNA 5-hydroxyU34 O-methylase TrmR/YrrM is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 443298  Cd Length: 173  Bit Score: 42.48  E-value: 4.64e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490299905  31 IRELARALPPGTLADIGTATAVVPVRLAAdpAMAQ-WRFVGVDLDPAMLDEGVPRIARLGLAGRVALKVGDALAL----- 104
Cdd:COG4122    8 LYLLARLLGAKRILEIGTGTGYSTLWLAR--ALPDdGRLTTIEIDPERAAIARENFARAGLADRIRLILGDALEVlprla 85

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 490299905 105 --PFD----DAslsmvvsratlhhlpDKALS---LAEMFRVLRPGGVGVVHDMRRDAPPALLERFTQMRAA 166
Cdd:COG4122   86 dgPFDlvfiDA---------------DKSNYpdyLELALPLLRPGGLIVADNVLWHGRVADPARRDPSTRA 141
PLN02232 PLN02232
ubiquinone biosynthesis methyltransferase
 99-140 8.72e-05

ubiquinone biosynthesis methyltransferase


Pssm-ID: 165876  Cd Length: 160  Bit Score: 41.60  E-value: 8.72e-05
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|..
gi 490299905  99 GDALALPFDDASLSMVVSRATLHHLPDKALSLAEMFRVLRPG 140
Cdd:PLN02232  33 GDAIDLPFDDCEFDAVTMGYGLRNVVDRLRAMKEMYRVLKPG 74
PLN02336 PLN02336
phosphoethanolamine N-methyltransferase
 69-155 1.38e-04

phosphoethanolamine N-methyltransferase


Pssm-ID: 177970 [Multi-domain]  Cd Length: 475  Bit Score: 42.05  E-value: 1.38e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490299905  69 VGVDLDPAMLDEGVPRiaRLGLAGRVALKVGDALALPFDDASLSMVVSRATLHHLPDKALSLAEMFRVLRPGGVGVVHDM 148
Cdd:PLN02336 293 VGIDLSVNMISFALER--AIGRKCSVEFEVADCTKKTYPDNSFDVIYSRDTILHIQDKPALFRSFFKWLKPGGKVLISDY 370


                 ....*...
gi 490299905 149 -RRDAPPA 155
Cdd:PLN02336 371 cRSPGTPS 378
PRK10258 PRK10258
biotin biosynthesis protein BioC; Provisional
 66-142 2.54e-04

biotin biosynthesis protein BioC; Provisional


Pssm-ID: 182340 [Multi-domain]  Cd Length: 251  Bit Score: 40.90  E-value: 2.54e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490299905  66 WRFVG-----VDLDPAMLDEgvpriARLGLAGRVALkVGDALALPFDDASLSMVVSRATLHHLPDKALSLAEMFRVLRPG 140
Cdd:PRK10258  60 WRERGsqvtaLDLSPPMLAQ-----ARQKDAADHYL-AGDIESLPLATATFDLAWSNLAVQWCGNLSTALRELYRVVRPG 133


                 ..
gi 490299905 141 GV 142
Cdd:PRK10258 134 GV 135
Methyltransf_4 pfam02390
Putative methyltransferase; This is a family of putative methyltransferases. The aligned ...
 43-176 4.43e-03

Putative methyltransferase; This is a family of putative methyltransferases. The aligned region contains the GXGXG S-AdoMet binding site suggesting a putative methyltransferase activity.


Pssm-ID: 367068  Cd Length: 173  Bit Score: 36.50  E-value: 4.43e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490299905   43 LADIGTATAVVPVRLAadPAMAQWRFVGVDLDPAMLDEGVPRIARLGLAGrVALKVGDAL-ALP--FDDASLSMVV---- 115
Cdd:pfam02390   5 FLEIGCGMGGFLVAMA--KANPDKNFIGIEIRVPGVAKALKKIDALGLQN-LRILCGNALdVLPnyFPPGSLQKIFinfp 81

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 490299905  116 -----SRATLHHLPDKALsLAEMFRVLRPGgvGVVHdMRRDAPPALLERFTQMRAAANYPPTHLEE 176
Cdd:pfam02390  82 dpwpkKRHHKRRLLQPEF-LKEYARVLKPG--GVLH-LATDVEEYAEEMLKHLAEHPLFERLDLEN 143
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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