NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|490281428|ref|WP_004177335|]
View 

MULTISPECIES: NADH:ubiquinone reductase (Na(+)-transporting) subunit E [Klebsiella]

Protein Classification

NADH:ubiquinone reductase (Na(+)-transporting) subunit E( domain architecture ID 17589644)

NADH:ubiquinone reductase (Na(+)-transporting) subunit E (NqrE) is a component of the NQR complex, which catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na(+) ions from the cytoplasm to the periplasm

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
NqrE COG2209
Na+-transporting NADH:ubiquinone oxidoreductase, subunit NqrE [Energy production and ...
 1-198 9.99e-120

Na+-transporting NADH:ubiquinone oxidoreductase, subunit NqrE [Energy production and conversion]; Na+-transporting NADH:ubiquinone oxidoreductase, subunit NqrE is part of the Pathway/BioSystem: Na+-translocating NADH dehydrogenase


:

Pssm-ID: 441811  Cd Length: 202  Bit Score: 337.19  E-value: 9.99e-120
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490281428   1 MAHYISLFVRAVFVENMALAFFLGMCTFLAVSKKVSTAFGLGVAVTVVLGLAVPINNLVYNLVLRDGALV----EGVDLS 76
Cdd:COG2209    1 MEHLLSLFIKSIFIENMALAFFLGMCTFLAVSKKVKTAFGLGIAVIFVLTITVPLNWLIYNYLLKPGALAwaglADVDLS 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490281428  77 FLNFITFIGVIAALVQILEMILDKYFPALYNALGIFLPLIAVNCAIFGGVSFMVQRDYNFPESIVYGFGSGIGWMLAIVA 156
Cdd:COG2209   81 FLGLITFIGVIAAMVQILEMVLDKFSPALYNALGIFLPLITVNCAILGGSLFMVERDYNFGESVVYGFGSGLGWALAIVA 160

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|..
gi 490281428 157 MAGIREKMKYANVPAGLRGLGITFITTGLMALGFMSFSGVQL 198
Cdd:COG2209  161 LAAIREKLKYSDVPAGLRGLGITFITTGLMALAFMSFSGIKL 202
 
Name Accession Description Interval E-value
NqrE COG2209
Na+-transporting NADH:ubiquinone oxidoreductase, subunit NqrE [Energy production and ...
 1-198 9.99e-120

Na+-transporting NADH:ubiquinone oxidoreductase, subunit NqrE [Energy production and conversion]; Na+-transporting NADH:ubiquinone oxidoreductase, subunit NqrE is part of the Pathway/BioSystem: Na+-translocating NADH dehydrogenase


Pssm-ID: 441811  Cd Length: 202  Bit Score: 337.19  E-value: 9.99e-120
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490281428   1 MAHYISLFVRAVFVENMALAFFLGMCTFLAVSKKVSTAFGLGVAVTVVLGLAVPINNLVYNLVLRDGALV----EGVDLS 76
Cdd:COG2209    1 MEHLLSLFIKSIFIENMALAFFLGMCTFLAVSKKVKTAFGLGIAVIFVLTITVPLNWLIYNYLLKPGALAwaglADVDLS 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490281428  77 FLNFITFIGVIAALVQILEMILDKYFPALYNALGIFLPLIAVNCAIFGGVSFMVQRDYNFPESIVYGFGSGIGWMLAIVA 156
Cdd:COG2209   81 FLGLITFIGVIAAMVQILEMVLDKFSPALYNALGIFLPLITVNCAILGGSLFMVERDYNFGESVVYGFGSGLGWALAIVA 160

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|..
gi 490281428 157 MAGIREKMKYANVPAGLRGLGITFITTGLMALGFMSFSGVQL 198
Cdd:COG2209  161 LAAIREKLKYSDVPAGLRGLGITFITTGLMALAFMSFSGIKL 202
nqrE TIGR01940
NADH:ubiquinone oxidoreductase, Na(+)-translocating, E subunit; This model represents the NqrE ...
 3-197 1.11e-107

NADH:ubiquinone oxidoreductase, Na(+)-translocating, E subunit; This model represents the NqrE subunit of the six-protein, Na(+)-pumping NADH-quinone reductase of a number of marine and pathogenic Gram-negative bacteria. This oxidoreductase complex functions primarily as a sodium ion pump. [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 130995  Cd Length: 200  Bit Score: 307.07  E-value: 1.11e-107
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490281428    3 HYISLFVRAVFVENMALAFFLGMCTFLAVSKKVSTAFGLGVAVTVVLGLAVPINNLVYNLVLRDGALVEG----VDLSFL 78
Cdd:TIGR01940   2 HYLSLFVKAVFVENMALSFFLGMCTFLAVSKKVSTAFGLGVAVTFVLTITVPINNLIYTYILKDGALSWGgpaeVDLSFL 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490281428   79 NFITFIGVIAALVQILEMILDKYFPALYNALGIFLPLIAVNCAIFGGVSFMVQRDYNFPESIVYGFGSGIGWMLAIVAMA 158
Cdd:TIGR01940  82 ELITFIGVIAALVQILEMVLERFSPSLYNALGIFLPLITVNCAIFGGVLFMVQREYNFGESVVYGFGSGLGWMLAIVALA 161

                         170       180       190
                  ....*....|....*....|....*....|....*....
gi 490281428  159 GIREKMKYANVPAGLRGLGITFITTGLMALGFMSFSGVQ 197
Cdd:TIGR01940 162 GIREKLKYSDVPKGLQGLGITFITTGLMALAFMSFSGIQ 200
PRK12456 PRK12456
Na(+)-translocating NADH-quinone reductase subunit E; Provisional
 4-198 5.61e-78

Na(+)-translocating NADH-quinone reductase subunit E; Provisional


Pssm-ID: 84141  Cd Length: 199  Bit Score: 231.80  E-value: 5.61e-78
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490281428   4 YISLFVRAVFVENMALAFFLGMCTFLAVSKKVSTAFGLGVAVTVVLGLAVPINNLVYNLVLRDGALVEGVDLSFLNFITF 83
Cdd:PRK12456   5 YLTIFIRAVFVENMALNFFLGMCTFLAISKKVETAFGLGLTVTALLAIATPLNNLIYTYILRENALIDGVDLSFLDFITF 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490281428  84 IGVIAALVQILEMILDKYFPALYNALGIFLPLIAVNCAIFGGVSFMVQRDYNFPESIVYGFGSGIGWMLAIVAMAGIREK 163
Cdd:PRK12456  85 IGVLAALVQILEMVLERFLPSLHHTLGAFLPLLTIHCAIFGATIFMVQREYTFTESFVYGTGCGLGWMLAIISMAGLREK 164

                        170       180       190
                 ....*....|....*....|....*....|....*
gi 490281428 164 MKYANVPAGLRGLGITFITTGLMALGFMSFSGVQL 198
Cdd:PRK12456 165 MKYSNIPKGLQGLGIVFMTAGLMSLGFMSFSGIRL 199
Rnf-Nqr pfam02508
Rnf-Nqr subunit, membrane protein; This is a family of integral membrane proteins including ...
 4-196 1.13e-56

Rnf-Nqr subunit, membrane protein; This is a family of integral membrane proteins including Rhodobacter-specific nitrogen fixation (rnf) proteins RnfA and RnfE and Na+-translocating NADH:ubiquinone oxidoreductase (Na+-NQR) subunits NqrD and NqrE.


Pssm-ID: 460575  Cd Length: 181  Bit Score: 176.84  E-value: 1.13e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490281428    4 YISLFVRAVFVENMALAFFLGMCTFLAVSKKVSTAFGLGVAVTVVLGLAVPINNLVYNLVLrdgalvegvdlSFLNFITF 83
Cdd:pfam02508   1 LLKIFISGIFVNNPVLVQFLGLCPFLAVTKKLENALGMGLAVTFVLTLSNVVISLLRNFIP-----------DYLRIIVF 69

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490281428   84 IGVIAALVQILEMILDKYFPALYNALGIFLPLIAVNCAIFGGVSFMVQRDyNFPESIVYGFGSGIGWMLAIVAMAGIREK 163
Cdd:pfam02508  70 ILVIAALVQLVEMVLKAYSPALYKALGIFLPLIVTNCIILGRAEAFASKN-PFLESLVDGLGMGLGFTLALVLLAGIREL 148

                         170       180       190
                  ....*....|....*....|....*....|...
gi 490281428  164 MKYANVPAGLRGLGITFITTGLMALGFMSFSGV 196
Cdd:pfam02508 149 LGRGTPIGGQILGYQPLILAGLPPGAFMGFGGL 181
SLC6sbd_GAT1 cd11506
Na(+)- and Cl(-)-dependent GABA transporter 1; solute-binding domain; GAT1 transports ...
 45-166 1.00e-02

Na(+)- and Cl(-)-dependent GABA transporter 1; solute-binding domain; GAT1 transports gamma-aminobutyric acid (GABA). GABA is the main inhibitory neurotransmitter within the mammalian CNS. Human GAT1 is encoded by the SLC6A1 gene. GAT1 is expressed in brain and peripheral nervous system. The antiepileptic drug, Tiagabine, inhibits GAT1. This subgroup belongs to the solute carrier 6 (SLC6) transporter family.


Pssm-ID: 212075 [Multi-domain]  Cd Length: 598  Bit Score: 36.11  E-value: 1.00e-02
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490281428  45 VTVVLGLAVPINNLVYNLVLRDGALVEGVDLSFLNFIT------FIGVIAALVQILEMIldKYFPALYNAL--GIFLPLI 116
Cdd:cd11506  429 VSYLIGLSNITQGGIYVFKLFDYYSASGMSLLFLVFFEcvsiswFYGVNRFYDNIEEMV--GYRPCIWWKLcwSFFTPII 506

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 490281428 117 AVNCAIFGGVSF--MVQRDYNFPEsivygFGSGIGWMLAIVAMAGIREKMKY 166
Cdd:cd11506  507 VAGVFLFSAVQMtpLTMGNYVFPK-----WGQGVGWFMALSSMVLIPGYMAY 553
 
Name Accession Description Interval E-value
NqrE COG2209
Na+-transporting NADH:ubiquinone oxidoreductase, subunit NqrE [Energy production and ...
 1-198 9.99e-120

Na+-transporting NADH:ubiquinone oxidoreductase, subunit NqrE [Energy production and conversion]; Na+-transporting NADH:ubiquinone oxidoreductase, subunit NqrE is part of the Pathway/BioSystem: Na+-translocating NADH dehydrogenase


Pssm-ID: 441811  Cd Length: 202  Bit Score: 337.19  E-value: 9.99e-120
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490281428   1 MAHYISLFVRAVFVENMALAFFLGMCTFLAVSKKVSTAFGLGVAVTVVLGLAVPINNLVYNLVLRDGALV----EGVDLS 76
Cdd:COG2209    1 MEHLLSLFIKSIFIENMALAFFLGMCTFLAVSKKVKTAFGLGIAVIFVLTITVPLNWLIYNYLLKPGALAwaglADVDLS 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490281428  77 FLNFITFIGVIAALVQILEMILDKYFPALYNALGIFLPLIAVNCAIFGGVSFMVQRDYNFPESIVYGFGSGIGWMLAIVA 156
Cdd:COG2209   81 FLGLITFIGVIAAMVQILEMVLDKFSPALYNALGIFLPLITVNCAILGGSLFMVERDYNFGESVVYGFGSGLGWALAIVA 160

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|..
gi 490281428 157 MAGIREKMKYANVPAGLRGLGITFITTGLMALGFMSFSGVQL 198
Cdd:COG2209  161 LAAIREKLKYSDVPAGLRGLGITFITTGLMALAFMSFSGIKL 202
nqrE TIGR01940
NADH:ubiquinone oxidoreductase, Na(+)-translocating, E subunit; This model represents the NqrE ...
 3-197 1.11e-107

NADH:ubiquinone oxidoreductase, Na(+)-translocating, E subunit; This model represents the NqrE subunit of the six-protein, Na(+)-pumping NADH-quinone reductase of a number of marine and pathogenic Gram-negative bacteria. This oxidoreductase complex functions primarily as a sodium ion pump. [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 130995  Cd Length: 200  Bit Score: 307.07  E-value: 1.11e-107
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490281428    3 HYISLFVRAVFVENMALAFFLGMCTFLAVSKKVSTAFGLGVAVTVVLGLAVPINNLVYNLVLRDGALVEG----VDLSFL 78
Cdd:TIGR01940   2 HYLSLFVKAVFVENMALSFFLGMCTFLAVSKKVSTAFGLGVAVTFVLTITVPINNLIYTYILKDGALSWGgpaeVDLSFL 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490281428   79 NFITFIGVIAALVQILEMILDKYFPALYNALGIFLPLIAVNCAIFGGVSFMVQRDYNFPESIVYGFGSGIGWMLAIVAMA 158
Cdd:TIGR01940  82 ELITFIGVIAALVQILEMVLERFSPSLYNALGIFLPLITVNCAIFGGVLFMVQREYNFGESVVYGFGSGLGWMLAIVALA 161

                         170       180       190
                  ....*....|....*....|....*....|....*....
gi 490281428  159 GIREKMKYANVPAGLRGLGITFITTGLMALGFMSFSGVQ 197
Cdd:TIGR01940 162 GIREKLKYSDVPKGLQGLGITFITTGLMALAFMSFSGIQ 200
PRK12456 PRK12456
Na(+)-translocating NADH-quinone reductase subunit E; Provisional
 4-198 5.61e-78

Na(+)-translocating NADH-quinone reductase subunit E; Provisional


Pssm-ID: 84141  Cd Length: 199  Bit Score: 231.80  E-value: 5.61e-78
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490281428   4 YISLFVRAVFVENMALAFFLGMCTFLAVSKKVSTAFGLGVAVTVVLGLAVPINNLVYNLVLRDGALVEGVDLSFLNFITF 83
Cdd:PRK12456   5 YLTIFIRAVFVENMALNFFLGMCTFLAISKKVETAFGLGLTVTALLAIATPLNNLIYTYILRENALIDGVDLSFLDFITF 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490281428  84 IGVIAALVQILEMILDKYFPALYNALGIFLPLIAVNCAIFGGVSFMVQRDYNFPESIVYGFGSGIGWMLAIVAMAGIREK 163
Cdd:PRK12456  85 IGVLAALVQILEMVLERFLPSLHHTLGAFLPLLTIHCAIFGATIFMVQREYTFTESFVYGTGCGLGWMLAIISMAGLREK 164

                        170       180       190
                 ....*....|....*....|....*....|....*
gi 490281428 164 MKYANVPAGLRGLGITFITTGLMALGFMSFSGVQL 198
Cdd:PRK12456 165 MKYSNIPKGLQGLGIVFMTAGLMSLGFMSFSGIRL 199
RnfA COG4657
Na+-translocating ferredoxin:NAD+ oxidoreductase RNF, RnfA subunit [Energy production and ...
 1-196 2.05e-71

Na+-translocating ferredoxin:NAD+ oxidoreductase RNF, RnfA subunit [Energy production and conversion]; Na+-translocating ferredoxin:NAD+ oxidoreductase RNF, RnfA subunit is part of the Pathway/BioSystem: Na+-translocating Fd:NADH oxidoreductase


Pssm-ID: 443695  Cd Length: 193  Bit Score: 214.60  E-value: 2.05e-71
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490281428   1 MAHYISLFVRAVFVENMALAFFLGMCTFLAVSKKVSTAFGLGVAVTVVLGLAVPINNLVYNLVLrdgalvEGVDLSFLNF 80
Cdd:COG4657    1 MMELFLIFISAILVNNFVLVQFLGLCPFLGVSKKLETAIGMGLAVTFVMTLASAISWLIYNYIL------VPLGLEYLRT 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490281428  81 ITFIGVIAALVQILEMILDKYFPALYNALGIFLPLIAVNCAIFGGVSFMVQRDYNFPESIVYGFGSGIGWMLAIVAMAGI 160
Cdd:COG4657   75 IVFILVIAALVQFVEMVLKKVSPALYRALGIYLPLITTNCAVLGVALLNVQQGYNFLESLVFGFGAGLGFTLALVLFAGI 154

                        170       180       190
                 ....*....|....*....|....*....|....*.
gi 490281428 161 REKMKYANVPAGLRGLGITFITTGLMALGFMSFSGV 196
Cdd:COG4657  155 RERLELADVPKAFKGLPIALITAGLLSLAFMGFSGL 190
PRK01061 PRK01061
Na(+)-translocating NADH-quinone reductase subunit E; Provisional
 7-198 8.15e-68

Na(+)-translocating NADH-quinone reductase subunit E; Provisional


Pssm-ID: 234895  Cd Length: 244  Bit Score: 207.33  E-value: 8.15e-68
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490281428   7 LFVRAVFVENMALAFFLGMCTFLAVSKKVSTAFGLGVAVTVVLGLAVPINNLVYNLVLRDGAL------VEGVDLSFLNF 80
Cdd:PRK01061  14 IFLQATFIQNILLSNFLGMCSYLACSSRLSTANGLGMSVALVLTVTGSINWFVHAFITGPGALtwlspaLANVNLSFLEL 93

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490281428  81 ITFIGVIAALVQILEMILDKYFPALYNALGIFLPLIAVNCAIFGGVSFMVQRDYNFPESIVYGFGSGIGWMLAIVAMAGI 160
Cdd:PRK01061  94 IIFIVVIAAFTQILELLLEKVSRNLYLSLGIFLPLIAVNCAILGGVLFGITRNYPFIPMMIFSLGAGCGWWLAIVLFATI 173

                        170       180       190
                 ....*....|....*....|....*....|....*...
gi 490281428 161 REKMKYANVPAGLRGLGITFITTGLMALGFMSFSGVQL 198
Cdd:PRK01061 174 REKLAYSDVPKNLQGMGISFITTGLIAMAFMGLTGIDI 211
Rnf-Nqr pfam02508
Rnf-Nqr subunit, membrane protein; This is a family of integral membrane proteins including ...
 4-196 1.13e-56

Rnf-Nqr subunit, membrane protein; This is a family of integral membrane proteins including Rhodobacter-specific nitrogen fixation (rnf) proteins RnfA and RnfE and Na+-translocating NADH:ubiquinone oxidoreductase (Na+-NQR) subunits NqrD and NqrE.


Pssm-ID: 460575  Cd Length: 181  Bit Score: 176.84  E-value: 1.13e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490281428    4 YISLFVRAVFVENMALAFFLGMCTFLAVSKKVSTAFGLGVAVTVVLGLAVPINNLVYNLVLrdgalvegvdlSFLNFITF 83
Cdd:pfam02508   1 LLKIFISGIFVNNPVLVQFLGLCPFLAVTKKLENALGMGLAVTFVLTLSNVVISLLRNFIP-----------DYLRIIVF 69

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490281428   84 IGVIAALVQILEMILDKYFPALYNALGIFLPLIAVNCAIFGGVSFMVQRDyNFPESIVYGFGSGIGWMLAIVAMAGIREK 163
Cdd:pfam02508  70 ILVIAALVQLVEMVLKAYSPALYKALGIFLPLIVTNCIILGRAEAFASKN-PFLESLVDGLGMGLGFTLALVLLAGIREL 148

                         170       180       190
                  ....*....|....*....|....*....|...
gi 490281428  164 MKYANVPAGLRGLGITFITTGLMALGFMSFSGV 196
Cdd:pfam02508 149 LGRGTPIGGQILGYQPLILAGLPPGAFMGFGGL 181
rnfA TIGR01943
electron transport complex, RnfABCDGE type, A subunit; The six subunit complex RnfABCDGE in ...
 4-196 4.90e-54

electron transport complex, RnfABCDGE type, A subunit; The six subunit complex RnfABCDGE in Rhodobacter capsulatus encodes an apparent NADH oxidoreductase responsible for electron transport to nitrogenase, necessary for nitrogen fixation. A closely related complex in E. coli, RsxABCDGE (Reducer of SoxR), reduces the 2Fe-2S-containing superoxide sensor SoxR, active as a transcription factor when oxidized. This family of putative NADH oxidoreductase complexes exists in many of the same species as the related NQR, a Na(+)-translocating NADH-quinone reductase, but is distinct. This model describes the A subunit. [Energy metabolism, Electron transport]


Pssm-ID: 130998  Cd Length: 190  Bit Score: 170.61  E-value: 4.90e-54
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490281428    4 YISLFVRAVFVENMALAFFLGMCTFLAVSKKVSTAFGLGVAVTVVLGLAVPINNLVYNLVLrdgalvEGVDLSFLNFITF 83
Cdd:TIGR01943   3 FFLIFLSAVFVNNFVLVKFLGLCPFLGVSKKLETAIGMGLAVTFVMTLASVISWLVYNFIL------DPLNLEFLRTIVF 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490281428   84 IGVIAALVQILEMILDKYFPALYNALGIFLPLIAVNCAIFGGVSFMVQRDYNFPESIVYGFGSGIGWMLAIVAMAGIREK 163
Cdd:TIGR01943  77 ILVIAALVQFVEMVVRKTSPDLYRALGIFLPLITTNCAVLGVALLNIQLDYNLLQSIVYAVGAGLGFTLAMVIFAGIRER 156

                         170       180       190
                  ....*....|....*....|....*....|...
gi 490281428  164 MKYANVPAGLRGLGITFITTGLMALGFMSFSGV 196
Cdd:TIGR01943 157 LDLSDVPKAFRGSPIALITAGLMSLAFMGFQGL 189
PRK05151 PRK05151
electron transport complex protein RsxA; Provisional
 1-195 4.00e-50

electron transport complex protein RsxA; Provisional


Pssm-ID: 235352  Cd Length: 193  Bit Score: 160.54  E-value: 4.00e-50
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490281428   1 MAHYISLFVRAVFVENMALAFFLGMCTFLAVSKKVSTAFGLGVAVTVVLGLAVPINNLVYNLVLrdgalvEGVDLSFLNF 80
Cdd:PRK05151   1 MTEYLLLFVSTVLVNNFVLVKFLGLCPFMGVSKKLETAIGMGLATTFVLTLASICAWLVNTYIL------IPLDLIYLRT 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490281428  81 ITFIGVIAALVQILEMILDKYFPALYNALGIFLPLIAVNCAIFGGVSFMVQRDYNFPESIVYGFGSGIGWMLAIVAMAGI 160
Cdd:PRK05151  75 LAFILVIAVVVQFTEMVVRKTSPTLYRLLGIFLPLITTNCAVLGVALLNINLGHNFLQSALYGFGAAVGFSLVLVLFAAI 154

                        170       180       190
                 ....*....|....*....|....*....|....*
gi 490281428 161 REKMKYANVPAGLRGLGITFITTGLMALGFMSFSG 195
Cdd:PRK05151 155 RERLAVADVPAPFRGAAIALITAGLMSLAFMGFTG 189
RnfE COG4660
Na+-translocating ferredoxin:NAD+ oxidoreductase RNF, RnfE subunit [Energy production and ...
 4-162 2.96e-24

Na+-translocating ferredoxin:NAD+ oxidoreductase RNF, RnfE subunit [Energy production and conversion]; Na+-translocating ferredoxin:NAD+ oxidoreductase RNF, RnfE subunit is part of the Pathway/BioSystem: Na+-translocating Fd:NADH oxidoreductase


Pssm-ID: 443698  Cd Length: 209  Bit Score: 94.43  E-value: 2.96e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490281428   4 YISLFVRAVFVENMALAFFLGMCTFLAVSKKVSTAFGLGVAVTVVLGLAvpinNLVYNLvLRdgalvegvdlsflNFI-- 81
Cdd:COG4660    3 YKKIFTNGLWKNNPVFVQLLGLCPLLAVTTSATNGLGMGLATTFVLVCS----NILVSL-LR-------------NLIpd 64

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490281428  82 -----TFIGVIAALVQILEMILDKYFPALYNALGIFLPLIAVNCAIFGGV-SFMVQRdyNFPESIVYGFGSGIGWMLAIV 155
Cdd:COG4660   65 evripVFIVIIATFVTIVDLLMNAYFPELYKALGIFIPLIVVNCIILGRAeAFASKN--PVLPSALDGLGMGLGFTLALV 142


                 ....*..
gi 490281428 156 AMAGIRE 162
Cdd:COG4660  143 LLGAVRE 149
PRK12405 PRK12405
electron transport complex RsxE subunit; Provisional
 1-162 1.16e-20

electron transport complex RsxE subunit; Provisional


Pssm-ID: 237091  Cd Length: 231  Bit Score: 85.68  E-value: 1.16e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490281428   1 MAHYISLFVRAVFVENMALAFFLGMCTFLAVSKKVSTAFGLGVAVTVVLGLAvpinNLVYNLvlrdgalvegvdlsFLNF 80
Cdd:PRK12405   1 MSEYKEIFKNGLWKNNPALVQLLGLCPLLAVTTTATNALGLGLATTLVLVCS----NLTVSL--------------LRKW 62

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490281428  81 IT-------FIGVIAALVQILEMILDKYFPALYNALGIFLPLIAVNCAIFGGVSFMVQRDyNFPESIVYGFGSGIGWMLA 153
Cdd:PRK12405  63 IPkeiripiFVMIIASFVTVVQLLMNAYAYGLYQSLGIFIPLIVTNCIILGRAEAFASKN-GVLLSALDGLGMGLGFTLA 141


                 ....*....
gi 490281428 154 IVAMAGIRE 162
Cdd:PRK12405 142 LVVLGAIRE 150
rnfE TIGR01948
electron transport complex, RnfABCDGE type, E subunit; The six subunit complex RnfABCDGE in ...
 5-162 9.42e-19

electron transport complex, RnfABCDGE type, E subunit; The six subunit complex RnfABCDGE in Rhodobacter capsulatus encodes an apparent NADH oxidoreductase responsible for electron transport to nitrogenase, necessary for nitrogen fixation. A closely related complex in E. coli, RsxABCDGE (Reducer of SoxR), reduces the 2Fe-2S-containing superoxide sensor SoxR, active as a transcription factor when oxidized. This family of putative NADH oxidoreductase complexes exists in many of the same species as the related NQR, a Na(+)-translocating NADH-quinone reductase, but is distinct. This model describes the E subunit. [Energy metabolism, Electron transport]


Pssm-ID: 162619  Cd Length: 196  Bit Score: 79.69  E-value: 9.42e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490281428    5 ISLFVRAVFVENMALAFFLGMCTFLAVSKKVSTAFGLGVAVTVVLGLAVPINNLVYNLVLRDgalvegvdlsfLNFITFI 84
Cdd:TIGR01948   1 REEFKNGIWNNNPTLVQLLGLCPTLAVTTSAINGLGMGLATTFVLVGSNMVVSLVRKFIPKE-----------VRIPVFI 69

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 490281428   85 GVIAALVQILEMILDKYFPALYNALGIFLPLIAVNCAIFGGVSFMVQRDYNFPeSIVYGFGSGIGWMLAIVAMAGIRE 162
Cdd:TIGR01948  70 VIIASFVTCVDMLMNAYTYDLYKSLGIFIPLIVVNCIILGRAEAFASKNGVLP-SILDGLGMGLGFTLVLFVLGGIRE 146
PRK09292 PRK09292
Na(+)-translocating NADH-quinone reductase subunit D; Validated
 6-162 1.75e-09

Na(+)-translocating NADH-quinone reductase subunit D; Validated


Pssm-ID: 236457  Cd Length: 209  Bit Score: 54.90  E-value: 1.75e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490281428   6 SLFVRAVFVENMALAFFLGMCTFLAVSKKVSTAFGLGVAVTVVLGLAVPINNLVYNLVlrdgalvegvdLSFLNFITFIG 85
Cdd:PRK09292   9 KVLLGPLFDNNPIALQVLGICSALAVTTKLETALVMTLAVTFVTAFSNFFISLIRNHI-----------PNSVRIIVQMT 77

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 490281428  86 VIAALVQILEMILDKYFPALYNALGIFLPLIAVNCAIFGGVSFMVQRdyNFP-ESIVYGFGSGIGWMLAIVAMAGIRE 162
Cdd:PRK09292  78 IIASLVIVVDQVLKAYAYDISKQLSVFVGLIITNCIVMGRAEAFAMK--NPPiPSFLDGIGNGLGYGAILLIVAFFRE 153
SLC6sbd_GAT1 cd11506
Na(+)- and Cl(-)-dependent GABA transporter 1; solute-binding domain; GAT1 transports ...
 45-166 1.00e-02

Na(+)- and Cl(-)-dependent GABA transporter 1; solute-binding domain; GAT1 transports gamma-aminobutyric acid (GABA). GABA is the main inhibitory neurotransmitter within the mammalian CNS. Human GAT1 is encoded by the SLC6A1 gene. GAT1 is expressed in brain and peripheral nervous system. The antiepileptic drug, Tiagabine, inhibits GAT1. This subgroup belongs to the solute carrier 6 (SLC6) transporter family.


Pssm-ID: 212075 [Multi-domain]  Cd Length: 598  Bit Score: 36.11  E-value: 1.00e-02
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490281428  45 VTVVLGLAVPINNLVYNLVLRDGALVEGVDLSFLNFIT------FIGVIAALVQILEMIldKYFPALYNAL--GIFLPLI 116
Cdd:cd11506  429 VSYLIGLSNITQGGIYVFKLFDYYSASGMSLLFLVFFEcvsiswFYGVNRFYDNIEEMV--GYRPCIWWKLcwSFFTPII 506

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 490281428 117 AVNCAIFGGVSF--MVQRDYNFPEsivygFGSGIGWMLAIVAMAGIREKMKY 166
Cdd:cd11506  507 VAGVFLFSAVQMtpLTMGNYVFPK-----WGQGVGWFMALSSMVLIPGYMAY 553
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH