|
Name |
Accession |
Description |
Interval |
E-value |
| LacY_symp |
pfam01306 |
LacY proton/sugar symporter; This family is closely related to the sugar transporter family. |
6-416 |
0e+00 |
|
LacY proton/sugar symporter; This family is closely related to the sugar transporter family.
Pssm-ID: 396050 Cd Length: 413 Bit Score: 563.23 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490280332 6 LAPRERHNFVYFLLFFFFYYFIMSAYFPFFPVWLADVNHLTKTETGIVFSSISLFAIIFQPVFGLMSDKLGLRKHLLWTI 85
Cdd:pfam01306 1 MYPLKNTNFWMFGLFFFFYFFIMSAYFPFFPIWLHDVNHLSKTDTGIVFSCISLFSILFQPLFGLISDKLGLRKHLLWCI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490280332 86 TVLLILFAPFFIFVFSPLLQMNIIAGSLVGGIYLGIVFSSGSGAVEAYIERVSRANRFEYGKVRVAGCVGWALCASITGV 165
Cdd:pfam01306 81 TGLLVLFAPFFIYVFGPLLQSNILVGAIVGGVYLGFVFSAGAGAIEAYIEKVSRRSNFEYGKARMFGCVGWALCASIAGI 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490280332 166 LFGIDPNITFWIASGFALVLGLLLWLSRPESSNSAQVIEALGANRQAFSLRTAAELLRMPRFWGFIVYVVGVASVYDVFD 245
Cdd:pfam01306 161 LFSIDPQIVFWLGSGFALILALLLMFAKPDKSSSAIVADALGANKSAFSLRLALELFRMPKFWVFVLYVVGVACVYDVFD 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490280332 246 QQFANFFKSFFASPQRGTEVFGFVTTGGELLNALIMFCAPAIVNRIGAKNALLTAGMIMSVRILGSSFASSAVEVVILKM 325
Cdd:pfam01306 241 QQFANFFTSFFATPQQGTRVFGYVTTMGELLNALIMFCAPLIINRIGAKNALLIAGTIMSVRILGSSFATTALEVVILKM 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490280332 326 LHMFEIPFLLVGTFKYISSAFNPRLSATLFLIGFNLSKQLSGVVLSAWVGRMYDTVGFHQAYLILGCITLSFTLLSFVTL 405
Cdd:pfam01306 321 LHMFEVPFLLVGCFKYITSQFDVRLSATIYLIGFQFSKQLAMILLSTLAGIMYDSIGFQGAYLVLGGIVLSFTLISVFTL 400
|
410
....*....|...
gi 490280332 406 RG--GNRLLPTAE 416
Cdd:pfam01306 401 SGsgPQILLPRPV 413
|
|
| 2A0105 |
TIGR00882 |
oligosaccharide:H+ symporter; [Transport and binding proteins, Carbohydrates, organic alcohols, ... |
27-405 |
0e+00 |
|
oligosaccharide:H+ symporter; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 211613 Cd Length: 396 Bit Score: 547.04 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490280332 27 IMSAYFPFFPVWLADVNHLTKTETGIVFSSISLFAIIFQPVFGLMSDKLGLRKHLLWTITVLLILFAPFFIFVFSPLLQM 106
Cdd:TIGR00882 17 IMSAYFPFFPIWLHDVNGLSKTDTGIVFSCISLFSILFQPLFGLISDKLGLKKHLLWIISGLLVLFAPFFIYVFGPLLQS 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490280332 107 NIIAGSLVGGIYLGIVFSSGSGAVEAYIERVSRANRFEYGKVRVAGCVGWALCASITGVLFGIDPNITFWIASGFALVLG 186
Cdd:TIGR00882 97 NILVGAIVGGLYLGFVFSAGAGAIEAYIEKVSRNSNFEYGKARMFGCVGWALCASIAGILFSIDPQIVFWLGSGFALILM 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490280332 187 LLLWLSRPESSNSAQVIEALGANRQAFSLRTAAELLRMPRFWGFIVYVVGVASVYDVFDQQFANFFKSFFASPQRGTEVF 266
Cdd:TIGR00882 177 LLLMFAKPKAPSSATVANALGANASAFSLKLALELFRQRKFWMFVLYVVGVACVYDVFDQQFANFFTSFFATPQQGTRVF 256
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490280332 267 GFVTTGGELLNALIMFCAPAIVNRIGAKNALLTAGMIMSVRILGSSFASSAVEVVILKMLHMFEIPFLLVGTFKYISSAF 346
Cdd:TIGR00882 257 GYVTTMGELLNALIMFCAPLIINRIGAKNALLIAGTIMSVRIIGSSFATTALEVVILKMLHAFEVPFLLVGCFKYITSQF 336
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*....
gi 490280332 347 NPRLSATLFLIGFNLSKQLSGVVLSAWVGRMYDTVGFHQAYLILGCITLSFTLLSFVTL 405
Cdd:TIGR00882 337 DVRLSATIYLIGFQFAKQLAMIFLSTLAGNMYDSIGFQGAYLVLGCIVLLFTLISVFTL 395
|
|
| lacY |
PRK09528 |
galactoside permease; Reviewed |
27-421 |
0e+00 |
|
galactoside permease; Reviewed
Pssm-ID: 236549 Cd Length: 420 Bit Score: 535.25 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490280332 27 IMSAYFPFFPVWLADVNHLTKTETGIVFSSISLFAIIFQPVFGLMSDKLGLRKHLLWTITVLLILFAPFFIFVFSPLLQM 106
Cdd:PRK09528 25 IWSSWFSFFPIWLHDINGLSGTDTGIIFSANSLFALLFQPLYGLISDKLGLKKHLLWIISGLLVLFGPFFIYVFAPLLQY 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490280332 107 NIIAGSLVGGIYLGIVFSSGSGAVEAYIERVSRANRFEYGKVRVAGCVGWALCASITGVLFGIDPNITFWIASGFALVLG 186
Cdd:PRK09528 105 NILLGAIVGGIYLGFGFLAGAGAIEAYIERVSRRSGFEYGRARMWGSLGWALCAFIAGILFNINPQINFWLGSGSALILL 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490280332 187 LLLWLSRPESSNSAQVIEALGANRQAFSLRTAAELLRMPRFWGFIVYVVGVASVYDVFDQQFANFFKSFFASPQRGTEVF 266
Cdd:PRK09528 185 VLLFFAKPDAPSTAKVANALGANASAVSLKDALALLKLPKFWFLVLYVIGVACFYDVFDQQFPNFFASFFATPEQGTRVF 264
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490280332 267 GFVTTGGELLNALIMFCAPAIVNRIGAKNALLTAGMIMSVRILGSSFASSAVEVVILKMLHMFEIPFLLVGTFKYISSAF 346
Cdd:PRK09528 265 GYLNSFQVFLEALIMFFAPFIINRIGAKNALLLAGTIMAVRIIGSGFATGPLEVSILKLLHAFEVPFLLVGVFKYITLNF 344
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 490280332 347 NPRLSATLFLIGFNLSKQLSGVVLSAWVGRMYDTVGFHQAYLILGCITLSFTLLSFVTLRGGNRLLPTAETQSPA 421
Cdd:PRK09528 345 DVRLSATIYLVGFQFAKQLGAVFLSTLAGNLYDSIGFQGTYLILGGIVLLFTLISVFTLSGDRELSLLRRQVPEA 419
|
|
| MFS_LacY |
cd06172 |
LacY proton/sugar symporter family of the Major Facilitator Superfamily of transporters; LacY ... |
27-405 |
1.33e-180 |
|
LacY proton/sugar symporter family of the Major Facilitator Superfamily of transporters; LacY proton/sugar family (also called LacY/RafB family) symporters are integral membrane proteins responsible for the transport of specific beta-glucosides into the cell accompanied by the import of a proton. Members include lactose permease (LacY), raffinose permease (RafB), and sucrose permease, which facilitate the transport of beta-galactosides, raffinose, and sucrose, respectively. The prototypical member, LacY, contains 12 transmembrane helices connected by hydrophilic loops with both N and C termini on the cytoplasmic face. The LacY/RafB permease family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340862 [Multi-domain] Cd Length: 389 Bit Score: 508.31 E-value: 1.33e-180
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490280332 27 IMSAYFPFFPVWLADVNHLTKTETGIVFSSISLFAIIFQPVFGLMSDKLGLRKHLLWTITVLLILFAPFFIFVFSPLLQM 106
Cdd:cd06172 14 IWSASFSFFPIWLTQINHLSGSETGIVFSANSLFALLFQPVYGLISDKLGLKKHLLWFISGLLVLFGPFFIFVYGPLLQS 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490280332 107 NIIAGSLVGGIYLGIVFSSGSGAVEAYIERVSRANRFEYGKVRVAGCVGWALCASITGVLFGIDPNITFWIASGFALVLG 186
Cdd:cd06172 94 NILLGAIVGGIYLGFAFLAGCGAIESYIERVSRRFNFEYGRARMWGSLGWALAAFFAGILFNINPNINFWLGSGFALILL 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490280332 187 LLLWLSRPESSNSAqviEALGANRQAFSLRTAAELLRMPRFWGFIVYVVGVASVYDVFDQQFANFFKSFFASPQRGTEVF 266
Cdd:cd06172 174 LLLLFAKPEDSDTA---AAAGANASSVSLKDVLELFRMPKFWFFILFVIGVSCFYDVFDQQFPPYFTSLFATPEQGNRVF 250
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490280332 267 GFVTTGGELLNALIMFCAPAIVNRIGAKNALLTAGMIMSVRILGSSFASSAVEVVILKMLHMFEIPFLLVGTFKYISSAF 346
Cdd:cd06172 251 GYLNSAQVFLEAGMMFLAPLIVNRIGAKNGLLLAGTIMAVRIIGSGLATSPLEISILKLLHAFEVPLLLVSIFKYITSHF 330
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*....
gi 490280332 347 NPRLSATLFLIGFNLSKQLSGVVLSAWVGRMYDTVGFHQAYLILGCITLSFTLLSFVTL 405
Cdd:cd06172 331 DTRLSATLYLVGFQFAKQLGAVVLSPLAGNLYDSIGFQQTYLVLGGIVLVFTLISVFTL 389
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
32-406 |
8.21e-19 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 87.63 E-value: 8.21e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490280332 32 FPFFPVWLADVNHLTKTETGIVFSSISLFAIIFQPVFGLMSDKLGLRKhllWTITVLLILFAPFFIFVFSPLLQMnIIAG 111
Cdd:COG2223 24 WSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRR---VLLIGLLLLGIGLLLLALAVSYWL-LLLL 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490280332 112 SLVGGIYLGIVFSSGSGAVEAYIERVSRAnrFEYGKVRVAGCVGWALCASITGVLFG-IDPNITFWIASGFALVLGLLLW 190
Cdd:COG2223 100 GLLLGIGGGGSFAVGIALVSKWFPPDRRG--LALGLAAGGGNLGAAVAAFLAPLLIAaFGWRNAFLILGILLLVVAVLAW 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490280332 191 LsrpessnSAQVIEALGANRQAFSLRTAAELLRMPRFWGFIVYVVGVASVYDVFDQQFANFFKSFFASPQrgtEVFGFVT 270
Cdd:COG2223 178 L-------FLRDPPAGAAAAAKASLRDQLEALRDPRFWLLSLLYFGTFGSFIGFSSWLPPYLVDQFGLSA---ATAGLLA 247
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490280332 271 TGGELLNALIMFCAPAIVNRIGAKNALLTAGMIMSVRILGSSFAS-SAVEVVILKMLHMFEIPFLLVGTFKYISSAFNPR 349
Cdd:COG2223 248 ALFALLGALGRPLGGWLSDRIGGRRVLLIVFALMALGLLLLALALgSLWLFLVLFLLLGLALGGGNGAVFALVPDIFPTK 327
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*....
gi 490280332 350 LSATlfLIGF-NLSKQLSGVVLSAWVGRMYDTVG-FHQAYLILGCITLSFTLLSFVTLR 406
Cdd:COG2223 328 NAGA--VYGLvGAAGGLGGFLGPLLFGALLDATGsYTAAFLVFAVLALVALVLTLLLYR 384
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| LacY_symp |
pfam01306 |
LacY proton/sugar symporter; This family is closely related to the sugar transporter family. |
6-416 |
0e+00 |
|
LacY proton/sugar symporter; This family is closely related to the sugar transporter family.
Pssm-ID: 396050 Cd Length: 413 Bit Score: 563.23 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490280332 6 LAPRERHNFVYFLLFFFFYYFIMSAYFPFFPVWLADVNHLTKTETGIVFSSISLFAIIFQPVFGLMSDKLGLRKHLLWTI 85
Cdd:pfam01306 1 MYPLKNTNFWMFGLFFFFYFFIMSAYFPFFPIWLHDVNHLSKTDTGIVFSCISLFSILFQPLFGLISDKLGLRKHLLWCI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490280332 86 TVLLILFAPFFIFVFSPLLQMNIIAGSLVGGIYLGIVFSSGSGAVEAYIERVSRANRFEYGKVRVAGCVGWALCASITGV 165
Cdd:pfam01306 81 TGLLVLFAPFFIYVFGPLLQSNILVGAIVGGVYLGFVFSAGAGAIEAYIEKVSRRSNFEYGKARMFGCVGWALCASIAGI 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490280332 166 LFGIDPNITFWIASGFALVLGLLLWLSRPESSNSAQVIEALGANRQAFSLRTAAELLRMPRFWGFIVYVVGVASVYDVFD 245
Cdd:pfam01306 161 LFSIDPQIVFWLGSGFALILALLLMFAKPDKSSSAIVADALGANKSAFSLRLALELFRMPKFWVFVLYVVGVACVYDVFD 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490280332 246 QQFANFFKSFFASPQRGTEVFGFVTTGGELLNALIMFCAPAIVNRIGAKNALLTAGMIMSVRILGSSFASSAVEVVILKM 325
Cdd:pfam01306 241 QQFANFFTSFFATPQQGTRVFGYVTTMGELLNALIMFCAPLIINRIGAKNALLIAGTIMSVRILGSSFATTALEVVILKM 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490280332 326 LHMFEIPFLLVGTFKYISSAFNPRLSATLFLIGFNLSKQLSGVVLSAWVGRMYDTVGFHQAYLILGCITLSFTLLSFVTL 405
Cdd:pfam01306 321 LHMFEVPFLLVGCFKYITSQFDVRLSATIYLIGFQFSKQLAMILLSTLAGIMYDSIGFQGAYLVLGGIVLSFTLISVFTL 400
|
410
....*....|...
gi 490280332 406 RG--GNRLLPTAE 416
Cdd:pfam01306 401 SGsgPQILLPRPV 413
|
|
| 2A0105 |
TIGR00882 |
oligosaccharide:H+ symporter; [Transport and binding proteins, Carbohydrates, organic alcohols, ... |
27-405 |
0e+00 |
|
oligosaccharide:H+ symporter; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 211613 Cd Length: 396 Bit Score: 547.04 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490280332 27 IMSAYFPFFPVWLADVNHLTKTETGIVFSSISLFAIIFQPVFGLMSDKLGLRKHLLWTITVLLILFAPFFIFVFSPLLQM 106
Cdd:TIGR00882 17 IMSAYFPFFPIWLHDVNGLSKTDTGIVFSCISLFSILFQPLFGLISDKLGLKKHLLWIISGLLVLFAPFFIYVFGPLLQS 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490280332 107 NIIAGSLVGGIYLGIVFSSGSGAVEAYIERVSRANRFEYGKVRVAGCVGWALCASITGVLFGIDPNITFWIASGFALVLG 186
Cdd:TIGR00882 97 NILVGAIVGGLYLGFVFSAGAGAIEAYIEKVSRNSNFEYGKARMFGCVGWALCASIAGILFSIDPQIVFWLGSGFALILM 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490280332 187 LLLWLSRPESSNSAQVIEALGANRQAFSLRTAAELLRMPRFWGFIVYVVGVASVYDVFDQQFANFFKSFFASPQRGTEVF 266
Cdd:TIGR00882 177 LLLMFAKPKAPSSATVANALGANASAFSLKLALELFRQRKFWMFVLYVVGVACVYDVFDQQFANFFTSFFATPQQGTRVF 256
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490280332 267 GFVTTGGELLNALIMFCAPAIVNRIGAKNALLTAGMIMSVRILGSSFASSAVEVVILKMLHMFEIPFLLVGTFKYISSAF 346
Cdd:TIGR00882 257 GYVTTMGELLNALIMFCAPLIINRIGAKNALLIAGTIMSVRIIGSSFATTALEVVILKMLHAFEVPFLLVGCFKYITSQF 336
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*....
gi 490280332 347 NPRLSATLFLIGFNLSKQLSGVVLSAWVGRMYDTVGFHQAYLILGCITLSFTLLSFVTL 405
Cdd:TIGR00882 337 DVRLSATIYLIGFQFAKQLAMIFLSTLAGNMYDSIGFQGAYLVLGCIVLLFTLISVFTL 395
|
|
| lacY |
PRK09528 |
galactoside permease; Reviewed |
27-421 |
0e+00 |
|
galactoside permease; Reviewed
Pssm-ID: 236549 Cd Length: 420 Bit Score: 535.25 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490280332 27 IMSAYFPFFPVWLADVNHLTKTETGIVFSSISLFAIIFQPVFGLMSDKLGLRKHLLWTITVLLILFAPFFIFVFSPLLQM 106
Cdd:PRK09528 25 IWSSWFSFFPIWLHDINGLSGTDTGIIFSANSLFALLFQPLYGLISDKLGLKKHLLWIISGLLVLFGPFFIYVFAPLLQY 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490280332 107 NIIAGSLVGGIYLGIVFSSGSGAVEAYIERVSRANRFEYGKVRVAGCVGWALCASITGVLFGIDPNITFWIASGFALVLG 186
Cdd:PRK09528 105 NILLGAIVGGIYLGFGFLAGAGAIEAYIERVSRRSGFEYGRARMWGSLGWALCAFIAGILFNINPQINFWLGSGSALILL 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490280332 187 LLLWLSRPESSNSAQVIEALGANRQAFSLRTAAELLRMPRFWGFIVYVVGVASVYDVFDQQFANFFKSFFASPQRGTEVF 266
Cdd:PRK09528 185 VLLFFAKPDAPSTAKVANALGANASAVSLKDALALLKLPKFWFLVLYVIGVACFYDVFDQQFPNFFASFFATPEQGTRVF 264
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490280332 267 GFVTTGGELLNALIMFCAPAIVNRIGAKNALLTAGMIMSVRILGSSFASSAVEVVILKMLHMFEIPFLLVGTFKYISSAF 346
Cdd:PRK09528 265 GYLNSFQVFLEALIMFFAPFIINRIGAKNALLLAGTIMAVRIIGSGFATGPLEVSILKLLHAFEVPFLLVGVFKYITLNF 344
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 490280332 347 NPRLSATLFLIGFNLSKQLSGVVLSAWVGRMYDTVGFHQAYLILGCITLSFTLLSFVTLRGGNRLLPTAETQSPA 421
Cdd:PRK09528 345 DVRLSATIYLVGFQFAKQLGAVFLSTLAGNLYDSIGFQGTYLILGGIVLLFTLISVFTLSGDRELSLLRRQVPEA 419
|
|
| MFS_LacY |
cd06172 |
LacY proton/sugar symporter family of the Major Facilitator Superfamily of transporters; LacY ... |
27-405 |
1.33e-180 |
|
LacY proton/sugar symporter family of the Major Facilitator Superfamily of transporters; LacY proton/sugar family (also called LacY/RafB family) symporters are integral membrane proteins responsible for the transport of specific beta-glucosides into the cell accompanied by the import of a proton. Members include lactose permease (LacY), raffinose permease (RafB), and sucrose permease, which facilitate the transport of beta-galactosides, raffinose, and sucrose, respectively. The prototypical member, LacY, contains 12 transmembrane helices connected by hydrophilic loops with both N and C termini on the cytoplasmic face. The LacY/RafB permease family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340862 [Multi-domain] Cd Length: 389 Bit Score: 508.31 E-value: 1.33e-180
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490280332 27 IMSAYFPFFPVWLADVNHLTKTETGIVFSSISLFAIIFQPVFGLMSDKLGLRKHLLWTITVLLILFAPFFIFVFSPLLQM 106
Cdd:cd06172 14 IWSASFSFFPIWLTQINHLSGSETGIVFSANSLFALLFQPVYGLISDKLGLKKHLLWFISGLLVLFGPFFIFVYGPLLQS 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490280332 107 NIIAGSLVGGIYLGIVFSSGSGAVEAYIERVSRANRFEYGKVRVAGCVGWALCASITGVLFGIDPNITFWIASGFALVLG 186
Cdd:cd06172 94 NILLGAIVGGIYLGFAFLAGCGAIESYIERVSRRFNFEYGRARMWGSLGWALAAFFAGILFNINPNINFWLGSGFALILL 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490280332 187 LLLWLSRPESSNSAqviEALGANRQAFSLRTAAELLRMPRFWGFIVYVVGVASVYDVFDQQFANFFKSFFASPQRGTEVF 266
Cdd:cd06172 174 LLLLFAKPEDSDTA---AAAGANASSVSLKDVLELFRMPKFWFFILFVIGVSCFYDVFDQQFPPYFTSLFATPEQGNRVF 250
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490280332 267 GFVTTGGELLNALIMFCAPAIVNRIGAKNALLTAGMIMSVRILGSSFASSAVEVVILKMLHMFEIPFLLVGTFKYISSAF 346
Cdd:cd06172 251 GYLNSAQVFLEAGMMFLAPLIVNRIGAKNGLLLAGTIMAVRIIGSGLATSPLEISILKLLHAFEVPLLLVSIFKYITSHF 330
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*....
gi 490280332 347 NPRLSATLFLIGFNLSKQLSGVVLSAWVGRMYDTVGFHQAYLILGCITLSFTLLSFVTL 405
Cdd:cd06172 331 DTRLSATLYLVGFQFAKQLGAVVLSPLAGNLYDSIGFQQTYLVLGGIVLVFTLISVFTL 389
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
32-406 |
8.21e-19 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 87.63 E-value: 8.21e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490280332 32 FPFFPVWLADVNHLTKTETGIVFSSISLFAIIFQPVFGLMSDKLGLRKhllWTITVLLILFAPFFIFVFSPLLQMnIIAG 111
Cdd:COG2223 24 WSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRR---VLLIGLLLLGIGLLLLALAVSYWL-LLLL 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490280332 112 SLVGGIYLGIVFSSGSGAVEAYIERVSRAnrFEYGKVRVAGCVGWALCASITGVLFG-IDPNITFWIASGFALVLGLLLW 190
Cdd:COG2223 100 GLLLGIGGGGSFAVGIALVSKWFPPDRRG--LALGLAAGGGNLGAAVAAFLAPLLIAaFGWRNAFLILGILLLVVAVLAW 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490280332 191 LsrpessnSAQVIEALGANRQAFSLRTAAELLRMPRFWGFIVYVVGVASVYDVFDQQFANFFKSFFASPQrgtEVFGFVT 270
Cdd:COG2223 178 L-------FLRDPPAGAAAAAKASLRDQLEALRDPRFWLLSLLYFGTFGSFIGFSSWLPPYLVDQFGLSA---ATAGLLA 247
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490280332 271 TGGELLNALIMFCAPAIVNRIGAKNALLTAGMIMSVRILGSSFAS-SAVEVVILKMLHMFEIPFLLVGTFKYISSAFNPR 349
Cdd:COG2223 248 ALFALLGALGRPLGGWLSDRIGGRRVLLIVFALMALGLLLLALALgSLWLFLVLFLLLGLALGGGNGAVFALVPDIFPTK 327
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*....
gi 490280332 350 LSATlfLIGF-NLSKQLSGVVLSAWVGRMYDTVG-FHQAYLILGCITLSFTLLSFVTLR 406
Cdd:COG2223 328 NAGA--VYGLvGAAGGLGGFLGPLLFGALLDATGsYTAAFLVFAVLALVALVLTLLLYR 384
|
|
| MFS_MFSD6 |
cd17335 |
Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily ... |
25-354 |
5.56e-14 |
|
Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily domain-containing protein 6 (MFSD6) is also called macrophage MHC class I receptor 2 homolog (MMR2). It has been postulated as a possible receptor for human leukocyte antigen (HLA)-B62. MFSD6 is conserved through evolution and appeared before bilateral animals. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340893 [Multi-domain] Cd Length: 375 Bit Score: 73.00 E-value: 5.56e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490280332 25 YFIMSAYFPFFPVWLADVnHLTKTETGIVFSSISLFAIIFQPVFGLMSDKLGLRKHLLWTITVLLILFAPFFIFVfspll 104
Cdd:cd17335 10 FAALGSLLPFLSVYLKQL-GLSPTQIGILIGIRPFVRFLSAPLWGALADRFGKRKALLLLSLLAAVLFFLSLFFV----- 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490280332 105 qMNIIAGSLVGGIYLGIVFSSGSGAVEAYIERVSRANRFEYGKVRVAGCVGWALCASITGVLFG-----IDPNITFWIAS 179
Cdd:cd17335 84 -AQIFWLLLLLVILGAFFSAPVVPLVDSITLQYLGEERERYGKQRLWGSIGFGIAALLVGILIDrsstyKNYTIAFYVFA 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490280332 180 GFALVLGLLlwlsrpessnSAQVIEALGANRQAFSLRTAAELLRMPRFWGFIVYVVGVASVYDVFDQQFANFFKSFFASP 259
Cdd:cd17335 163 VLMLLALLL----------ALKFPFRPKHPEPNENTGGLLALLRNPRVLAFLLVAFLMGFGHGLIYSFLFWHLQDLGGSK 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490280332 260 QrgteVFGFVTTGGELLNALIMFCAPAIVNRIGAKNALLTAGMIMSVRILGSSFASSAVEVVILKMLHMFEIPFLLVGTF 339
Cdd:cd17335 233 T----LIGLLWTVGVVSEIPFFFFSSRLIQRFGHVGLLYLGLLAYVVRWLLYSFLENPWLVLPIELLHGLTFALVWAAAV 308
|
330
....*....|....*
gi 490280332 340 KYISSAFNPRLSATL 354
Cdd:cd17335 309 SYASAAAPPGLRATA 323
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
28-403 |
1.99e-10 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 61.82 E-value: 1.99e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490280332 28 MSAYFPFFPVWLADVnHLTKTETGIVFSSISLFAIIFQPVFGLMSDKLGLRKHLLWTitvLLILFAPFFIFVFSPLLQMN 107
Cdd:cd17325 12 YGIIIPILPLYAESL-GASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLG---LLLLAVSTLLFAFATSYWQL 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490280332 108 IIAgSLVGGIYLGIVFSSGSGAVEAYIERVSRANRFeyGKVRVAGCVGWALCASITGVLFG-IDPNITFWIASGFALVLG 186
Cdd:cd17325 88 LLA-RFLQGLASAAVWPAAMALIADIAPPEERGRAM--GIFSSAIGLGFLIGPLLGGLLADaLGYRAPFLVCAALALLAL 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490280332 187 LLLWLSRPESSNSAqvieALGANRQAFSLRTAAELLRMPRFWGFIVYVVGVASVYDVFDQQFANFFKSFFASpqrGTEVF 266
Cdd:cd17325 165 VLALLLLPEPRPPP----NKRAVSAARLRSGLRLLLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGL---SPAQI 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490280332 267 GFVTTGGELLNALIMFCAPAIVNRIGAKNALLTAGMIMSVRILGSSFASSAVEVVILKMLHMFEIPFLLVGTFKYISSAF 346
Cdd:cd17325 238 GLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVALLLLPLATSFWLLLLLLALLGLGLGLVFPATLALLADIV 317
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*..
gi 490280332 347 NPRLSATLFLIgFNLSKQLSGVVLSAWVGRMYDTVGFHQAYLILGCITLSFTLLSFV 403
Cdd:cd17325 318 PPEGRGTAMGL-FNTAFSLGMVLGPLLGGFLYDAFGFATPFLAAAALLLLAAVLFLL 373
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
27-402 |
7.57e-10 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 60.13 E-value: 7.57e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490280332 27 IMSAYFPFFPVWLADVnHLTKTETGIVFSSISLFAIIFQPVFGLMSDKLGLRKHLLWTItVLLILFAPFFIFVFSPLLqm 106
Cdd:cd06174 11 ARGLISPLLPALLQSF-GLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGL-LLFALGALLFAFAPSFWL-- 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490280332 107 nIIAGSLVGGIYLGIVFSSGSGAVEAYIERVSRANRFeyGKVRVAGCVGWALCASITGVLFGIDPN---ITFWIASGFAL 183
Cdd:cd06174 87 -LLLGRFLLGLGSGLIDPAVLALIADLFPERERGRAL--GLLQAFGSVGGILGPLLGGILASSLGFgwrAVFLIAAALAL 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490280332 184 VLGLLLWLSRPESSNSAQVIEAlgANRQAFSLRTAAELLRMPRFWGFIVYVVGVASVYDVFDQQFANFFKSFFASpqrGT 263
Cdd:cd06174 164 LAAILLLLVVPDPPESARAKNE--EASSKSVLKLLKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGL---SV 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490280332 264 EVFGFVTTGGELLNALIMFCAPAIVNR-IGAKNALLTAGMIMSVRILGSSFASSAVEVVILKMLHMFEIPFLLVGTFKYI 342
Cdd:cd06174 239 AVAGLLLSLFGLAGALGSLLLGLLSDRlIGRKPLLLIGLLLMALGLALLLLAPSLLLLLLLLLLLGFGLGGLLPLSFALI 318
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 490280332 343 SSAFNPRLSATLFLIgFNLSKQLSGVVLSAWVGRMYDTV-GFHQAYLILGCITLSFTLLSF 402
Cdd:cd06174 319 AELFPPEIRGTAFGL-LNTFGFLGGAIGPLLAGFLLAATfGLTGAFLVLAVLLLLAAILLL 378
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
28-355 |
3.17e-09 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 58.06 E-value: 3.17e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490280332 28 MSAYFPFFPVWLADVnHLTKTETGIVFSSISLFAIIFQPVFGLMSDKLGLRKHLLWTItVLLILFAPFFIFVFSPLLqmn 107
Cdd:COG2814 26 IGIVLPALPLIAADL-GASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGL-LLFALGSLLCALAPSLWL--- 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490280332 108 IIAGSLVGGIYLGIVFSSGSGAVEAYIERVSRANRFeyGKVRVAGCVGWALCASITGVLFG-IDPNITFWIASGFALVLG 186
Cdd:COG2814 101 LLAARFLQGLGAGALFPAALALIADLVPPERRGRAL--GLLGAGLGLGPALGPLLGGLLADlFGWRWVFLVNAVLALLAL 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490280332 187 LLLWLSRPESsnsaqviealGANRQAFSLRTAAELLRMPRFWGFIVYVVGVASVYDVFDQQFANFFKSFFaspQRGTEVF 266
Cdd:COG2814 179 LLLLRLLPES----------RPAARARLRGSLRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVL---GLSASAA 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490280332 267 GFVTTGGELLNALIMFCAPAIVNRIGAKNALLTAGMIMSVRILGSSFASSAVEVVILKMLHMFEIPFLLVGTFKYISSAF 346
Cdd:COG2814 246 GLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALGLLLLALAGSLWLLLLALFLLGFGFGLLFPLLQALVAELA 325
|
....*....
gi 490280332 347 NPRLSATLF 355
Cdd:COG2814 326 PPEARGRAS 334
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
28-323 |
1.05e-07 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 53.58 E-value: 1.05e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490280332 28 MSAYFPFFPVWLADVNHLTKTETGIVFSSISLFAIIFQPVFGLMSDKLGLRKhlLWTITVLLILFAPFFIFVFSPLLQMn 107
Cdd:pfam07690 12 RSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRR--VLLIGLLLFALGLLLLLFASSLWLL- 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490280332 108 iIAGSLVGGIYLGIVFSSGSGAVEAYIERVSRAnrFEYGKVRVAGCVGWALCASITGVLFG-IDPNITFWIASGFALVLG 186
Cdd:pfam07690 89 -LVLRVLQGLGAGALFPAALALIADWFPPEERG--RALGLVSAGFGLGAALGPLLGGLLASlFGWRAAFLILAILSLLAA 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490280332 187 LLLWLSRPESSNSAQVIEALGANRQAFSLRtaaELLRMPRFWGFIVYVVGVASVYdvfdqQFANFFKSFFASPQRGTEVF 266
Cdd:pfam07690 166 VLLLLPRPPPESKRPKPAEEARLSLIVAWK---ALLRDPVLWLLLALLLFGFAFF-----GLLTYLPLYQEVLGLSALLA 237
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*..
gi 490280332 267 GFVTTGGELLNALIMFCAPAIVNRIGAKNALLTAGMIMSVRILGSSFASSAVEVVIL 323
Cdd:pfam07690 238 GLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLILAALGLLLLSLTLSSLWL 294
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
29-395 |
1.85e-07 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 52.61 E-value: 1.85e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490280332 29 SAYFPFFPVWLADVNHLTKTETGIVFSSISLFAIIFQPVFGLMSDKLGLRKHLLWTITVLLILFApFFIFVFSPLLqmnI 108
Cdd:cd17329 16 FMVWPFMAIYLHQQLGLSASIVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFA-LLGFAHSPWL---F 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490280332 109 IAGSLVGGIYLGIVFSsgsgAVEAYIERVSRANRFE--YGKVRVAGCVGWALCASITGVLFGIDPNITFWIASGFALVLG 186
Cdd:cd17329 92 AIALVLTGFGGGLFEP----ASEAMIADVTTPENRTraFSLLYWAINLGVAIGPLLGGLLLLYSFRLLFLAAAVLFLLAA 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490280332 187 LLLWLSRPESSNSAQviealgANRQAFSLRTAAELLRMPRFWGFIVYVVGVASVYDVFDQQFANFFKSFFASPQRgteVF 266
Cdd:cd17329 168 LVLLFLLPETRPKRR------AAEKTEILRGYKIVLRDRAFLLFLLASFLISLIYFQLESTLPVYVVEILGLGES---LL 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490280332 267 GFVTTGGELLNALIMFCAPAIVNRIGAKNALLTAGMIMSVRILGSSFASS-AVEVVILKMLHMFEIpfLLVGTFKYISSA 345
Cdd:cd17329 239 GLLLALNALLIVLLQFPVARLVERFRLRKILMIGILLFAIGFAVLAFANTlAVLILAMIVLTLGEM--LVFPAVQTLVAA 316
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|
gi 490280332 346 FNPRLSATLFLIGFNLSKQLSGVVLSAWVGRMYDTVGFHQAYLILGCITL 395
Cdd:cd17329 317 LAPPDKRGSYMGFYALAWGLGRAIGPLVGGLLLDLLGPGLPWLILAALGL 366
|
|
| MFS_1_like |
pfam12832 |
MFS_1 like family; This family contains proteins related to the MFS superfamily. |
27-354 |
2.67e-07 |
|
MFS_1 like family; This family contains proteins related to the MFS superfamily.
Pssm-ID: 432817 [Multi-domain] Cd Length: 362 Bit Score: 52.25 E-value: 2.67e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490280332 27 IMSAYFPFFPVWLADVNhLTKTETGIVFSSISLFAIIFQPVFGLMSDKLGLRKhllwtitvLLILFAPFFIFVFSPLLQM 106
Cdd:pfam12832 14 ALGCLLPYWGLYLRSIG-LNPSEIGLITAILPLTRILAPPIWGWLADRTGKRK--------AVVRLASILAAVLFLSVLF 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490280332 107 NIIAGSLVGGIYLGIVFSSGSGAVEAYIERVS----RANRFEYGKVRVAGCVGWALCASITGVLF-----GIDPNITFWI 177
Cdd:pfam12832 85 IPISLTFWWLALLVVLFSFFWNAILPQFEVATlqhlGEKRKDYGRQRLWGSVGFALSVFGLGALFdhysvGLLPSVLFYL 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490280332 178 ASGFALVLGLLLWLSRPESSNSAQVIEALGANRqafslrtaaelLRMPRFWGFIVYVVGVASVYDVFDQQFANFFKSFFA 257
Cdd:pfam12832 165 FAALMLLSLLLPLAPPEMEYESKGGSKAVFWNL-----------LKQPEVIIFFLAAFLLGFSHGPFYTFLFLYLENLGA 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490280332 258 SPqrgtEVFGFVTTGGELLNALIMFCAPAIVNRIGAKNALLTAGMIMSVRILG-SSFASSAVEVVILKMLHMFEIPFLLV 336
Cdd:pfam12832 234 SN----TLLGALWALGVVAEIPLFFYAHRLLRRFGHRNLLIIALLLTALRWLLyAFFVENPWLVLPIQFLHAISFGLTHA 309
|
330
....*....|....*...
gi 490280332 337 GTFKYISSAFNPRLSATL 354
Cdd:pfam12832 310 AAIEYVRRIFPGSLQGTG 327
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
27-306 |
3.85e-05 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 45.66 E-value: 3.85e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490280332 27 IMSAYFPFFpvwLADVNHLTKTETGIVFSSISLFAIIFQPVFGLMSD----KLGLRKHLLWTITVLLILFApFFIFVFSP 102
Cdd:COG2211 28 LLSAYLLYF---YTDVLGLSAALVGLILLVARLWDAITDPLIGALSDrtrtRWGRRRPWILIGAIPLALSF-VLLFTAPD 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490280332 103 LLQMNIIAGSLVGGIYLGIVFSSGSGAVEA--------YIERvSRANRFeygkVRVAGCVGWALCASITGVLFGIDPN-- 172
Cdd:COG2211 104 LSPTGKLIYALVTYLLLGLAYTLVNIPYSAlgaeltpdYEER-TRLSSW----RFAFAGLGGLLASVLPPPLVAAFGGda 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490280332 173 -----ITFWIASGFALVLGLLLWLSRPESSNSAQVIEALganrqafsLRTAAELLRMPRFWGFIVYVVGVASVYDVFDQQ 247
Cdd:COG2211 179 algyrLTALIFAVLGLLAFLLTFFGTKERPVPEEEKVSL--------KESLKALLKNRPFLLLLLAYLLFFLALALVAAL 250
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*....
gi 490280332 248 FANFFKSFFaspQRGTEVFGFVTTGGELLNALIMFCAPAIVNRIGAKNALLTAGMIMSV 306
Cdd:COG2211 251 LLYYFKYVL---GLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAAL 306
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
44-406 |
2.04e-04 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 43.32 E-value: 2.04e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490280332 44 HLTKTETGIVFSSISLFAIIFQPVFGLMSDKLGlRKHLLWTITVLLILFAPFFIFVFSPLLqmnIIAGSLVGGIYLGIVF 123
Cdd:COG2271 41 GLSAAQLGLLASAFFLGYALGQIPAGLLADRFG-RRRVLAIGLLLWGLATLLFGFATSFWQ---LLLLRFLLGLGEAGFF 116
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490280332 124 SSGSGAVEAYIERVSRAnrFEYGKVRVAGCVGWALCASITGVLFG-IDPNITFWIASGFALvlglllwlsrpessnsaqv 202
Cdd:COG2271 117 PAALKLIAEWFPPKERG--RALGIFNAGGPLGGALAPPLLGWLLAaFGWRAAFLILGLPGL------------------- 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490280332 203 iealganrqafslrtaaeLLRMPRFWGFIVYVVGVASVYDVFDQQFANFFKSFFASPQrgtEVFGFVTTGGELLNALIMF 282
Cdd:COG2271 176 ------------------LLALLRFWLLALAYFLVYFALYGFLTWLPTYLVEVRGLSL---AQAGLLLSLPFLAGIVGSL 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490280332 283 CAPAIVNRIGA--KNALLTAGMIMSVRILGSSFASSAVEVVILKMLHMFEIPFLLVGTFKYISSAFNPRLSATLFLIgFN 360
Cdd:COG2271 235 LGGWLSDRLGRrrKLVLAIGLLLAALALLLLALLPSPALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGL-VN 313
|
330 340 350 360
....*....|....*....|....*....|....*....|....*.
gi 490280332 361 LSKQLSGVVLSAWVGRMYDTVGFHQAYLILGCITLSFTLLSFVTLR 406
Cdd:COG2271 314 TFGFLGGALGPLLVGYLLDATGYQAAFLLLAALALLAALLALLLLR 359
|
|
| MFS_CsbX |
cd17337 |
CsbX family of the Major Facilitator Superfamily of transporters; The CsbX family is composed ... |
30-115 |
5.10e-04 |
|
CsbX family of the Major Facilitator Superfamily of transporters; The CsbX family is composed of Bacillus subtilis CsbX protein (also named alpha-ketoglutarate permease), Klebsiella pneumoniae D-arabinitol transporter (DalT), and similar proteins. The csbX gene is a sigmaB-controlled gene that is expressed during the stationary phase of cell growth. DalT is a pentose-specific ion symporter for D-arabinitol uptake. Most members of this family remain uncharacterized. The CsbX family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340895 [Multi-domain] Cd Length: 388 Bit Score: 42.10 E-value: 5.10e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490280332 30 AYFPFFPVWLADVNHLTKTETGIVFSSISLFAIIFQPVFGLMSDKLGLRKHLLW------TITVLLILFAPFFifvFSPL 103
Cdd:cd17337 226 GFPVFMPLYFTDTGGFSTSQWLQIWGIIFLVNIFFNLIFGILGDKIGWRRTVRWfggvgcAISTLLFYYVPQL---FGHN 302
|
90
....*....|..
gi 490280332 104 LQMNIIAGSLVG 115
Cdd:cd17337 303 YWAALIAAILFG 314
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
35-162 |
5.46e-04 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 41.79 E-value: 5.46e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490280332 35 FPVWLADVNHLTKTETGIVFSSISLFAIIFQPVFGLMSDKLGLRKHLLwtITVLLILFAPFFIFVFSPLLQMNIIAGSL- 113
Cdd:cd17503 201 LPLYLQNVLGYSAFESGLVLAPGGLASAILSPLVGRLLDKFGPRLLLL--AGLLLLALGTLLLAFLTPDTSLWLIILPLf 278
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|.
gi 490280332 114 VGGIYLGIVFSSGSGAVEAYI--ERVSRANRFEYGKVRVAGCVGWALCASI 162
Cdd:cd17503 279 IRGLGMGLVFMPLNTLALNSLppEQIGDATALFNTIRQLGGSIGTALLATL 329
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
30-134 |
1.46e-03 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 40.66 E-value: 1.46e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490280332 30 AYFPFFPVWLADVNHLTKTETGIVFSSISLFAIIFQPVFGLMSDKLGLRKHLLWTITVLLILFAPFFIFVFSPLLQMnii 109
Cdd:cd17316 195 GLTTFLPTYLQTVLGLSPATSSLYLLLISLGALVGALIAGLLSDRIGRKKTLVIGLILSGILALPLFYLLSGSPTLL--- 271
|
90 100
....*....|....*....|....*
gi 490280332 110 agsLVGGIYLGIVFSSGSGAVEAYI 134
Cdd:cd17316 272 ---LLLLFILSFFVGGVWGALYAYL 293
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
34-133 |
1.97e-03 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 40.24 E-value: 1.97e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490280332 34 FFPVWLADVNHLTKTETGIVFSSISLFAIIFQPVFGLMSDKLGLRKHLLWTITVLLILFApFFIFVFSPLLQMNIIAGSL 113
Cdd:COG2271 202 WLPTYLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRRKLVLAIGLLLAALA-LLLLALLPSPALAIALLFL 280
|
90 100
....*....|....*....|
gi 490280332 114 VGGIYLGIVFSSGSGAVEAY 133
Cdd:COG2271 281 AGFGLGGAFGLLWALAAELF 300
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
50-403 |
3.06e-03 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 39.52 E-value: 3.06e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490280332 50 TGIVFSSISLFAIIFQPVFGLMSDKLGLRKHLLWTITVLLILFAPFFIFVFSPLLQMNIIagsLVGGIYLGIVFSSGSGA 129
Cdd:cd06173 36 VGLVLAAFFLPFLLFSPFAGVLADRFDRRRLLILADLLRALLAAVLALLALLGSLSLWLL---LVLAFLLGIASAFFGPA 112
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490280332 130 VEAYI------ERVSRANRFEYGKVRVAGCVGWALCASITGVLfgiDPNITFWIASG--FALVLGLLLWLSRPESSNSAQ 201
Cdd:cd06173 113 RQALLpelvpkEQLVRANALNSLATQLARIIGPALGGLLVALL---GPGGAFAINALsfLLSALLLLFIRRPPPAAPGES 189
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490280332 202 VIEALGANRQAFSLRTAAELLRMPRFWGFIVYVVGVAsvydvFDQQFANFFKSFFaspQRGTEVFGFVTTGGELLNALIM 281
Cdd:cd06173 190 SSLLLRDLREGLRYLRRSPLLRLLLLALALFALLGGA-----LTVLLPLLAKEVL---GGGAAGYGLLLAAFGVGALLGA 261
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490280332 282 FCAPAIVNRIGAKNALLTAGMIMSVRILGSSFASSAVEVVILKMLHMFEIPFLLVGTFKYISSAFNPRLSATLFLIgFNL 361
Cdd:cd06173 262 LLLGRLSKRRRRGRLLLIGALLLGLALLVLGLSPSLWLLLAALFLLGLAGGLFNVPLNTLLQLRVPDELRGRVFSV-YNA 340
|
330 340 350 360
....*....|....*....|....*....|....*....|..
gi 490280332 362 SKQLSGVVLSAWVGRMYDTVGFHQAYLILGCITLSFTLLSFV 403
Cdd:cd06173 341 LNSGAMPLGALLAGLLADALGLSAVFLLAGALLLLAALLLLL 382
|
|
| MFS_ShiA_like |
cd17369 |
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This ... |
58-132 |
9.39e-03 |
|
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli shikimate transporter (ShiA), inner membrane metabolite transport protein YhjE, and other putative metabolite transporters. ShiA is involved in the uptake of shikimate, an aromatic compound involved in siderophore biosynthesis. It has been suggested that YhjE may mediate the uptake of osmoprotectants. The ShiA-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340927 [Multi-domain] Cd Length: 408 Bit Score: 37.89 E-value: 9.39e-03
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 490280332 58 SLFAIIFQPVFGLMSDKLGLRKHLLWTITVLLILFAPFFifvfsPLLQMNIIAGSLVGGIYLGIVFSSGSGAVEA 132
Cdd:cd17369 274 SVVAAITIPLFGWLSDRVGRRPVYLAGALLAALFAFPFF-----WLLDTGSTWLIVLAAVVVLGVLHGMMYGPQA 343
|
|
| |
