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Conserved domains on  [gi|490278289|ref|WP_004174237|]
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MULTISPECIES: acid-sensing system DNA-binding response regulator EvgA [Enterobacteriaceae]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PRK09958 PRK09958
acid-sensing system DNA-binding response regulator EvgA;
1-204 7.75e-142

acid-sensing system DNA-binding response regulator EvgA;


:

Pssm-ID: 182168 [Multi-domain]  Cd Length: 204  Bit Score: 393.49  E-value: 7.75e-142
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490278289   1 MNAIIIDDHPLARIAIRNLLDSNGITVAAELDSGAHAVQTAESMQPDLLIVDVDIPELSGIEVLEQLRKRRYQGTIIIIS 80
Cdd:PRK09958   1 MNAIIIDDHPLAIAAIRNLLIKNDIEILAELTEGGSAVQRVETLKPDIVIIDVDIPGVNGIQVLETLRKRQYSGIIIIVS 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490278289  81 AKNELFYGKRSADCGANGFVSKKEGMNNILAAIDAANNGYSYFPFSLERFCTHGITDQDRLDTLSTQEMKVFRYILSGVD 160
Cdd:PRK09958  81 AKNDHFYGKHCADAGANGFVSKKEGMNNIIAAIEAAKNGYCYFPFSLNRFVGSLTSDQQKLDSLSKQEISVMRYILDGKD 160

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....
gi 490278289 161 YTTIGSKMNISNKTVSTYKVRLMDKLGCSTLLELYDFAQRNKIG 204
Cdd:PRK09958 161 NNDIAEKMFISNKTVSTYKSRLMEKLECKSLMDLYTFAQRNKIG 204
 
Name Accession Description Interval E-value
PRK09958 PRK09958
acid-sensing system DNA-binding response regulator EvgA;
1-204 7.75e-142

acid-sensing system DNA-binding response regulator EvgA;


Pssm-ID: 182168 [Multi-domain]  Cd Length: 204  Bit Score: 393.49  E-value: 7.75e-142
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490278289   1 MNAIIIDDHPLARIAIRNLLDSNGITVAAELDSGAHAVQTAESMQPDLLIVDVDIPELSGIEVLEQLRKRRYQGTIIIIS 80
Cdd:PRK09958   1 MNAIIIDDHPLAIAAIRNLLIKNDIEILAELTEGGSAVQRVETLKPDIVIIDVDIPGVNGIQVLETLRKRQYSGIIIIVS 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490278289  81 AKNELFYGKRSADCGANGFVSKKEGMNNILAAIDAANNGYSYFPFSLERFCTHGITDQDRLDTLSTQEMKVFRYILSGVD 160
Cdd:PRK09958  81 AKNDHFYGKHCADAGANGFVSKKEGMNNIIAAIEAAKNGYCYFPFSLNRFVGSLTSDQQKLDSLSKQEISVMRYILDGKD 160

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....
gi 490278289 161 YTTIGSKMNISNKTVSTYKVRLMDKLGCSTLLELYDFAQRNKIG 204
Cdd:PRK09958 161 NNDIAEKMFISNKTVSTYKSRLMEKLECKSLMDLYTFAQRNKIG 204
REC_NarL-like cd17535
phosphoacceptor receiver (REC) domain of NarL (Nitrate/Nitrite response regulator L) family ...
 4-116 7.11e-34

phosphoacceptor receiver (REC) domain of NarL (Nitrate/Nitrite response regulator L) family response regulators; The NarL family is one of the more abundant families of DNA-binding response regulators (RRs). Members of the NarL family contain a REC domain and a helix-turn-helix (HTH) DNA-binding output domain, with a majority of members containing a LuxR-type HTH domain. They function as transcriptional regulators. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381090 [Multi-domain]  Cd Length: 117  Bit Score: 116.84  E-value: 7.11e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490278289   4 IIIDDHPLARIAIRNLLDSN-GITVAAELDSGAHAVQTAESMQPDLLIVDVDIPELSGIEVLEQLRKRRYQGTIIIISAK 82
Cdd:cd17535    2 LIVDDHPLVREGLRRLLESEpDIEVVGEAADGEEALALLRELRPDVVLMDLSMPGMDGIEALRRLRRRYPDLKVIVLTAH 81

                         90       100       110
                 ....*....|....*....|....*....|....
gi 490278289  83 NELFYGKRSADCGANGFVSKKEGMNNILAAIDAA 116
Cdd:cd17535   82 DDPEYVLRALKAGAAGYLLKDSSPEELIEAIRAV 115
Response_reg pfam00072
Response regulator receiver domain; This domain receives the signal from the sensor partner in ...
 4-114 2.61e-31

Response regulator receiver domain; This domain receives the signal from the sensor partner in bacterial two-component systems. It is usually found N-terminal to a DNA binding effector domain.


Pssm-ID: 395025 [Multi-domain]  Cd Length: 111  Bit Score: 109.93  E-value: 2.61e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490278289    4 IIIDDHPLARIAIRNLLDSNGITVAaELDSGAHAVQTAESMQPDLLIVDVDIPELSGIEVLEQLRKRRYQGTIIIISAKN 83
Cdd:pfam00072   2 LIVDDDPLIRELLRQLLEKEGYVVA-EADDGKEALELLKEERPDLILLDINMPGMDGLELLKRIRRRDPTTPVIILTAHG 80

                          90       100       110
                  ....*....|....*....|....*....|.
gi 490278289   84 ELFYGKRSADCGANGFVSKKEGMNNILAAID 114
Cdd:pfam00072  81 DEDDAVEALEAGADDFLSKPFDPDELLAAIR 111
CitB COG2197
DNA-binding response regulator, NarL/FixJ family, contains REC and HTH domains [Signal ...
 1-203 8.13e-24

DNA-binding response regulator, NarL/FixJ family, contains REC and HTH domains [Signal transduction mechanisms, Transcription];


Pssm-ID: 441799 [Multi-domain]  Cd Length: 131  Bit Score: 91.49  E-value: 8.13e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490278289   1 MNAIIIDDHPLARIAIRNLLDSN-GITVAAELDSGAHAVQTAESMQPDLLIVDVDIPELSGIEVLEQLrkrryqgtiiii 79
Cdd:COG2197    2 IRVLIVDDHPLVREGLRALLEAEpDIEVVGEAADGEEALELLEELRPDVVLLDIRMPGMDGLEALRRL------------ 69

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490278289  80 saknelfygkrsadcgangfvskkegmnnilaaidaanngysyfpfslerfcthgitdqdrldtLSTQEMKVFRYILSGV 159
Cdd:COG2197   70 ----------------------------------------------------------------LTPREREVLRLLAEGL 85

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....
gi 490278289 160 DYTTIGSKMNISNKTVSTYKVRLMDKLGCSTLLELYDFAQRNKI 203
Cdd:COG2197   86 SNKEIAERLGISERTVKTHVSNILRKLGVRNRTELVLLALRLGL 129
HTH_LUXR smart00421
helix_turn_helix, Lux Regulon; lux regulon (activates the bioluminescence operon
 141-198 5.27e-12

helix_turn_helix, Lux Regulon; lux regulon (activates the bioluminescence operon


Pssm-ID: 197715 [Multi-domain]  Cd Length: 58  Bit Score: 58.31  E-value: 5.27e-12
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 490278289   141 LDTLSTQEMKVFRYILSGVDYTTIGSKMNISNKTVSTYKVRLMDKLGCSTLLELYDFA 198
Cdd:smart00421   1 LASLTPREREVLRLLAEGLTNKEIAERLGISEKTVKTHLSNIMRKLGVRSRTQAVRLA 58
 
Name Accession Description Interval E-value
PRK09958 PRK09958
acid-sensing system DNA-binding response regulator EvgA;
1-204 7.75e-142

acid-sensing system DNA-binding response regulator EvgA;


Pssm-ID: 182168 [Multi-domain]  Cd Length: 204  Bit Score: 393.49  E-value: 7.75e-142
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490278289   1 MNAIIIDDHPLARIAIRNLLDSNGITVAAELDSGAHAVQTAESMQPDLLIVDVDIPELSGIEVLEQLRKRRYQGTIIIIS 80
Cdd:PRK09958   1 MNAIIIDDHPLAIAAIRNLLIKNDIEILAELTEGGSAVQRVETLKPDIVIIDVDIPGVNGIQVLETLRKRQYSGIIIIVS 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490278289  81 AKNELFYGKRSADCGANGFVSKKEGMNNILAAIDAANNGYSYFPFSLERFCTHGITDQDRLDTLSTQEMKVFRYILSGVD 160
Cdd:PRK09958  81 AKNDHFYGKHCADAGANGFVSKKEGMNNIIAAIEAAKNGYCYFPFSLNRFVGSLTSDQQKLDSLSKQEISVMRYILDGKD 160

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....
gi 490278289 161 YTTIGSKMNISNKTVSTYKVRLMDKLGCSTLLELYDFAQRNKIG 204
Cdd:PRK09958 161 NNDIAEKMFISNKTVSTYKSRLMEKLECKSLMDLYTFAQRNKIG 204
PRK09935 PRK09935
fimbriae biosynthesis transcriptional regulator FimZ;
4-199 4.65e-34

fimbriae biosynthesis transcriptional regulator FimZ;


Pssm-ID: 182154 [Multi-domain]  Cd Length: 210  Bit Score: 120.37  E-value: 4.65e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490278289   4 IIIDDHPLARIAIRNLLDSNG-ITVAAELDSGAHAVQTAESMQPDLLIVDVDIPELSGIEVLEQLRKRRYQGTIIIISAK 82
Cdd:PRK09935   7 IIMDTHPIIRMSIEVLLQKNSeLQIVLKTDDYRITIDYLRTRPVDLIIMDIDLPGTDGFTFLKRIKQIQSTVKVLFLSSK 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490278289  83 NELFYGKRSADCGANGFVSKKEGMNNILAAIDAANNGYSYFPFSLERFCTHGITDQDRLD--TLSTQEMKVFRYILSGVD 160
Cdd:PRK09935  87 SECFYAGRAIQAGANGFVSKCNDQNDIFHAVQMILSGYTFFPSETLNYIKSNKCSTNSSTdtVLSNREVTILRYLVSGLS 166

                        170       180       190
                 ....*....|....*....|....*....|....*....
gi 490278289 161 YTTIGSKMNISNKTVSTYKVRLMDKLGCSTLLELYDFAQ 199
Cdd:PRK09935 167 NKEIADQLLLSNKTVSAHKSNIYGKLGLHSIVELIDYAK 205
REC_NarL-like cd17535
phosphoacceptor receiver (REC) domain of NarL (Nitrate/Nitrite response regulator L) family ...
 4-116 7.11e-34

phosphoacceptor receiver (REC) domain of NarL (Nitrate/Nitrite response regulator L) family response regulators; The NarL family is one of the more abundant families of DNA-binding response regulators (RRs). Members of the NarL family contain a REC domain and a helix-turn-helix (HTH) DNA-binding output domain, with a majority of members containing a LuxR-type HTH domain. They function as transcriptional regulators. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381090 [Multi-domain]  Cd Length: 117  Bit Score: 116.84  E-value: 7.11e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490278289   4 IIIDDHPLARIAIRNLLDSN-GITVAAELDSGAHAVQTAESMQPDLLIVDVDIPELSGIEVLEQLRKRRYQGTIIIISAK 82
Cdd:cd17535    2 LIVDDHPLVREGLRRLLESEpDIEVVGEAADGEEALALLRELRPDVVLMDLSMPGMDGIEALRRLRRRYPDLKVIVLTAH 81

                         90       100       110
                 ....*....|....*....|....*....|....
gi 490278289  83 NELFYGKRSADCGANGFVSKKEGMNNILAAIDAA 116
Cdd:cd17535   82 DDPEYVLRALKAGAAGYLLKDSSPEELIEAIRAV 115
Response_reg pfam00072
Response regulator receiver domain; This domain receives the signal from the sensor partner in ...
 4-114 2.61e-31

Response regulator receiver domain; This domain receives the signal from the sensor partner in bacterial two-component systems. It is usually found N-terminal to a DNA binding effector domain.


Pssm-ID: 395025 [Multi-domain]  Cd Length: 111  Bit Score: 109.93  E-value: 2.61e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490278289    4 IIIDDHPLARIAIRNLLDSNGITVAaELDSGAHAVQTAESMQPDLLIVDVDIPELSGIEVLEQLRKRRYQGTIIIISAKN 83
Cdd:pfam00072   2 LIVDDDPLIRELLRQLLEKEGYVVA-EADDGKEALELLKEERPDLILLDINMPGMDGLELLKRIRRRDPTTPVIILTAHG 80

                          90       100       110
                  ....*....|....*....|....*....|.
gi 490278289   84 ELFYGKRSADCGANGFVSKKEGMNNILAAID 114
Cdd:pfam00072  81 DEDDAVEALEAGADDFLSKPFDPDELLAAIR 111
PRK15369 PRK15369
two component system response regulator;
4-200 8.38e-28

two component system response regulator;


Pssm-ID: 185267 [Multi-domain]  Cd Length: 211  Bit Score: 104.01  E-value: 8.38e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490278289   4 IIIDDHPLARIAIRNLLDS-NGITVAAELDSGAHAVQTAESMQPDLLIVDVDIPELSGIEVLEQLRKRRYQGTIIIISAK 82
Cdd:PRK15369   7 LLVDDHELIINGIKNMLAPyPRYKIVGQVDNGLEVYNACRQLEPDIVILDLGLPGMNGLDVIPQLHQRWPAMNILVLTAR 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490278289  83 NELFYGKRSADCGANGFVSKKEGMNNILAAIDAANNGYSYFPFSLERFCTHGITDQDRLD--TLSTQEMKVFRYILSGVD 160
Cdd:PRK15369  87 QEEHMASRTLAAGALGYVLKKSPQQILLAAIQTVAVGKRYIDPALNREAILALLNADDTNppLLTPRERQILKLITEGYT 166

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|
gi 490278289 161 YTTIGSKMNISNKTVSTYKVRLMDKLGCSTLLELYDFAQR 200
Cdd:PRK15369 167 NRDIAEQLSISIKTVETHRLNMMRKLDVHKVAELLNWARR 206
PRK09483 PRK09483
response regulator; Provisional
 1-203 7.82e-25

response regulator; Provisional


Pssm-ID: 236538 [Multi-domain]  Cd Length: 217  Bit Score: 96.71  E-value: 7.82e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490278289   1 MNAIIIDDHPLARIAIRNLL-DSNGITVAAELDSGAHAVQTAESMQPDLLIVDVDIPelsGIEVLEQLRK-RRYQG--TI 76
Cdd:PRK09483   2 INVLLVDDHELVRAGIRRILeDIKGIKVVGEACCGEDAVKWCRTNAVDVVLMDMNMP---GIGGLEATRKiLRYTPdvKI 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490278289  77 IIISAKNELFYGKRSADCGANGFVSKKEGMNNILAAIDAANNGYSYFP------FSLERFCThgiTDQDRLDTLSTQEMK 150
Cdd:PRK09483  79 IMLTVHTENPLPAKVMQAGAAGYLSKGAAPQEVVSAIRSVHSGQRYIAsdiaqqMALSQIEP---ATENPFASLSERELQ 155

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|...
gi 490278289 151 VFRYILSGVDYTTIGSKMNISNKTVSTYKVRLMDKLGCSTLLELYDFAQRNKI 203
Cdd:PRK09483 156 IMLMITKGQKVNEISEQLNLSPKTVNSYRYRMFSKLNISGDVELTHLAIRHGL 208
CitB COG2197
DNA-binding response regulator, NarL/FixJ family, contains REC and HTH domains [Signal ...
 1-203 8.13e-24

DNA-binding response regulator, NarL/FixJ family, contains REC and HTH domains [Signal transduction mechanisms, Transcription];


Pssm-ID: 441799 [Multi-domain]  Cd Length: 131  Bit Score: 91.49  E-value: 8.13e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490278289   1 MNAIIIDDHPLARIAIRNLLDSN-GITVAAELDSGAHAVQTAESMQPDLLIVDVDIPELSGIEVLEQLrkrryqgtiiii 79
Cdd:COG2197    2 IRVLIVDDHPLVREGLRALLEAEpDIEVVGEAADGEEALELLEELRPDVVLLDIRMPGMDGLEALRRL------------ 69

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490278289  80 saknelfygkrsadcgangfvskkegmnnilaaidaanngysyfpfslerfcthgitdqdrldtLSTQEMKVFRYILSGV 159
Cdd:COG2197   70 ----------------------------------------------------------------LTPREREVLRLLAEGL 85

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....
gi 490278289 160 DYTTIGSKMNISNKTVSTYKVRLMDKLGCSTLLELYDFAQRNKI 203
Cdd:COG2197   86 SNKEIAERLGISERTVKTHVSNILRKLGVRNRTELVLLALRLGL 129
YesN COG4753
Two-component response regulator, YesN/AraC family, consists of REC and AraC-type DNA-binding ...
 5-102 4.56e-22

Two-component response regulator, YesN/AraC family, consists of REC and AraC-type DNA-binding domains [Signal transduction mechanisms, Transcription];


Pssm-ID: 443786 [Multi-domain]  Cd Length: 103  Bit Score: 85.98  E-value: 4.56e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490278289   5 IIDDHPLARIAIRNLLDSN-GITVAAELDSGAHAVQTAESMQPDLLIVDVDIPELSGIEVLEQLRKRRYQGTIIIISAKN 83
Cdd:COG4753    4 IVDDEPLIREGLKRILEWEaGFEVVGEAENGEEALELLEEHKPDLVITDINMPGMDGLELLEAIRELDPDTKIIILSGYS 83

                         90
                 ....*....|....*....
gi 490278289  84 ELFYGKRSADCGANGFVSK 102
Cdd:COG4753   84 DFEYAQEAIKLGADDYLLK 102
FixJ COG4566
DNA-binding response regulator, FixJ family, consists of REC and HTH domains [Signal ...
 5-194 7.57e-22

DNA-binding response regulator, FixJ family, consists of REC and HTH domains [Signal transduction mechanisms, Transcription];


Pssm-ID: 443623 [Multi-domain]  Cd Length: 196  Bit Score: 88.23  E-value: 7.57e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490278289   5 IIDDHPLARIAIRNLLDSNGITVAAeLDSGAHAVQTAESMQPDLLIVDVDIPELSGIEVLEQLRKRRYQGTIIIISAkne 84
Cdd:COG4566    4 IVDDDEAVRDSLAFLLESAGLRVET-FASAEAFLAALDPDRPGCLLLDVRMPGMSGLELQEELAARGSPLPVIFLTG--- 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490278289  85 lfYG---------KRsadcGANGFVSKKEGMNNILAAIDAAnngysyFPFSLERFCTHGITD--QDRLDTLSTQEMKVFR 153
Cdd:COG4566   80 --HGdvpmavramKA----GAVDFLEKPFDDQALLDAVRRA------LARDRARRAERARRAelRARLASLTPREREVLD 147

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|.
gi 490278289 154 YILSGVDYTTIGSKMNISNKTVSTYKVRLMDKLGCSTLLEL 194
Cdd:COG4566  148 LVVAGLSNKQIARELGISPRTVEVHRANVMEKLGARSLAEL 188
PleD COG3706
Two-component response regulator, PleD family, consists of two REC domains and a diguanylate ...
 5-114 2.18e-21

Two-component response regulator, PleD family, consists of two REC domains and a diguanylate cyclase (GGDEF) domain [Signal transduction mechanisms, Transcription];


Pssm-ID: 442920 [Multi-domain]  Cd Length: 179  Bit Score: 86.50  E-value: 2.18e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490278289   5 IIDDHPLARIAIRNLLDSNGITVAaELDSGAHAVQTAESMQPDLLIVDVDIPELSGIEVLEQLRKR-RYQGT-IIIISAK 82
Cdd:COG3706    6 VVDDDPTNRKLLRRLLEAAGYEVV-EAADGEEALELLQEHRPDLILLDLEMPDMDGLELCRRLRADpRTADIpIIFLTAL 84

                         90       100       110
                 ....*....|....*....|....*....|..
gi 490278289  83 NELFYGKRSADCGANGFVSKKEGMNNILAAID 114
Cdd:COG3706   85 DDEEDRARALEAGADDYLTKPFDPEELLARVD 116
PRK10403 PRK10403
nitrate/nitrite response regulator protein NarP;
4-186 2.44e-21

nitrate/nitrite response regulator protein NarP;


Pssm-ID: 182431 [Multi-domain]  Cd Length: 215  Bit Score: 87.21  E-value: 2.44e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490278289   4 IIIDDHPLARIAIRNLLDSN-GITVAAELDSGAHAVQTAESMQPDLLIVDVDIPELSGIEVLEQLRKRRYQGTIIIISAK 82
Cdd:PRK10403  10 LIVDDHPLMRRGVRQLLELDpGFEVVAEAGDGASAIDLANRLDPDVILLDLNMKGMSGLDTLNALRRDGVTAQIIILTVS 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490278289  83 NELFYGKRSADCGANGFVSKKEGMNNILAAIDAANNGYSYFPFSLERFCTHGITDQDRLD---TLSTQEMKVFRYILSGV 159
Cdd:PRK10403  90 DASSDVFALIDAGADGYLLKDSDPEVLLEAIRAGAKGSKVFSERVNQYLREREMFGAEEDpfsVLTERELDVLHELAQGL 169

                        170       180
                 ....*....|....*....|....*..
gi 490278289 160 DYTTIGSKMNISNKTVSTYKVRLMDKL 186
Cdd:PRK10403 170 SNKQIASVLNISEQTVKVHIRNLLRKL 196
REC cd00156
phosphoacceptor receiver (REC) domain of response regulators (RRs) and pseudo response ...
 5-102 7.96e-20

phosphoacceptor receiver (REC) domain of response regulators (RRs) and pseudo response regulators (PRRs); Two-component systems (TCSs) involving a sensor and a response regulator are used by bacteria to adapt to changing environments. Processes regulated by two-component systems in bacteria include sporulation, pathogenicity, virulence, chemotaxis, and membrane transport. Response regulators (RRs) share the common phosphoacceptor REC domain and different effector/output domains such as DNA, RNA, ligand-binding, protein-binding, or enzymatic domains. Response regulators regulate transcription, post-transcription or post-translation, or have functions such as methylesterases, adenylate or diguanylate cyclase, c-di-GMP-specific phosphodiesterases, histidine kinases, serine/threonine protein kinases, and protein phosphatases, depending on their output domains. The function of some output domains are still unknown. TCSs are found in all three domains of life - bacteria, archaea, and eukaryotes, however, the presence and abundance of particular RRs vary between the lineages. Archaea encode very few RRs with DNA-binding output domains; most are stand-alone REC domains. Among eukaryotes, TCSs are found primarily in protozoa, fungi, algae, and green plants. REC domains function as phosphorylation-mediated switches within RRs, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381085 [Multi-domain]  Cd Length: 99  Bit Score: 80.35  E-value: 7.96e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490278289   5 IIDDHPLARIAIRNLLDSNGITVAAElDSGAHAVQTAESMQPDLLIVDVDIPELSGIEVLEQLRKRRYQGTIIIISAKNE 84
Cdd:cd00156    2 IVDDDPAIRELLKSLLEREGYEVDTA-ADGEEALELLREERPDLVLLDLMMPGMDGLELLRKLRELPPDIPVIVLTAKAD 80

                         90
                 ....*....|....*...
gi 490278289  85 LFYGKRSADCGANGFVSK 102
Cdd:cd00156   81 EEDAVRALELGADDYLVK 98
OmpR COG0745
DNA-binding response regulator, OmpR family, contains REC and winged-helix (wHTH) domain ...
 5-145 2.49e-19

DNA-binding response regulator, OmpR family, contains REC and winged-helix (wHTH) domain [Signal transduction mechanisms, Transcription];


Pssm-ID: 440508 [Multi-domain]  Cd Length: 204  Bit Score: 81.93  E-value: 2.49e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490278289   5 IIDDHPLARIAIRNLLDSNGITVAaELDSGAHAVQTAESMQPDLLIVDVDIPELSGIEVLEQLRKRRYQGTIIIISAKNE 84
Cdd:COG0745    6 VVEDDPDIRELLADALEREGYEVD-TAADGEEALELLEEERPDLILLDLMLPGMDGLEVCRRLRARPSDIPIIMLTARDD 84

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 490278289  85 LFYGKRSADCGANGFVSKKEGMNNILAAIDAAnngysyfpfsLERFCTHGITDQDRLDTLS 145
Cdd:COG0745   85 EEDRVRGLEAGADDYLTKPFDPEELLARIRAL----------LRRRAAEVLRVGDLLDLAA 135
PRK10360 PRK10360
transcriptional regulator UhpA;
5-194 4.79e-19

transcriptional regulator UhpA;


Pssm-ID: 182408 [Multi-domain]  Cd Length: 196  Bit Score: 80.79  E-value: 4.79e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490278289   5 IIDDHPLARIAIRNLLD-SNGITVAAELDSGAHAVQTAESMQPDLLIVDVDIPELSGIEVLEQLRKRRyqgTIIIISAKN 83
Cdd:PRK10360   6 LIDDHLIVRSGFAQLLGlEPDLQVVAEFGSGREALAGLPGRGVQVCICDISMPDISGLELLSQLPKGM---ATIMLSVHD 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490278289  84 ELFYGKRSADCGANGFVSKKEGMNNILAAIDAANNGYSYFPFSLERFCTHGitdqdRLDTLSTQEMKVFRYILSGVDYTT 163
Cdd:PRK10360  83 SPALVEQALNAGARGFLSKRCSPDELIAAVHTVATGGCYLTPDIAIKLASG-----RQDPLTKRERQVAEKLAQGMAVKE 157

                        170       180       190
                 ....*....|....*....|....*....|.
gi 490278289 164 IGSKMNISNKTVSTYKVRLMDKLGCSTLLEL 194
Cdd:PRK10360 158 IAAELGLSPKTVHVHRANLMEKLGVSNDVEL 188
CheY COG0784
CheY-like REC (receiver) domain, includes chemotaxis protein CheY and sporulation regulator ...
 5-102 9.32e-19

CheY-like REC (receiver) domain, includes chemotaxis protein CheY and sporulation regulator Spo0F [Signal transduction mechanisms];


Pssm-ID: 440547 [Multi-domain]  Cd Length: 128  Bit Score: 78.35  E-value: 9.32e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490278289   5 IIDDHPLARIAIRNLLDSNGITV-AAEldSGAHAVQTAESMQPDLLIVDVDIPELSGIEVLEQLRKR-RYQGT-IIIISA 81
Cdd:COG0784   10 VVDDNPDNRELLRRLLERLGYEVtTAE--DGAEALELLRAGPPDLILLDINMPGMDGLELLRRIRALpRLPDIpIIALTA 87

                         90       100
                 ....*....|....*....|.
gi 490278289  82 KNELFYGKRSADCGANGFVSK 102
Cdd:COG0784   88 YADEEDRERALEAGADDYLTK 108
PRK10651 PRK10651
transcriptional regulator NarL; Provisional
 4-204 1.16e-18

transcriptional regulator NarL; Provisional


Pssm-ID: 182619 [Multi-domain]  Cd Length: 216  Bit Score: 80.07  E-value: 1.16e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490278289   4 IIIDDHPLARIAIRNLLD-SNGITVAAELDSGAHAVQTAESMQPDLLIVDVDIPELSGIEVLEQLRKRRYQGTIIIISAK 82
Cdd:PRK10651  10 LLIDDHPMLRTGVKQLISmAPDITVVGEASNGEQGIELAESLDPDLILLDLNMPGMNGLETLDKLREKSLSGRIVVFSVS 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490278289  83 N---ELFYGKRSadcGANGFVSKKEGMNNILAAIDAANNGYSYFPFSLERFCTHGITDQDR-----LDTLSTQEMKVFRY 154
Cdd:PRK10651  90 NheeDVVTALKR---GADGYLLKDMEPEDLLKALQQAAAGEMVLSEALTPVLAASLRANRAtterdVNQLTPRERDILKL 166

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|
gi 490278289 155 ILSGVDYTTIGSKMNISNKTVSTYKVRLMDKLGCSTLLELYDFAQRNKIG 204
Cdd:PRK10651 167 IAQGLPNKMIARRLDITESTVKVHVKHMLKKMKLKSRVEAAVWVHQERIF 216
LytT COG3279
DNA-binding response regulator, LytR/AlgR family [Transcription, Signal transduction ...
 1-84 1.72e-18

DNA-binding response regulator, LytR/AlgR family [Transcription, Signal transduction mechanisms];


Pssm-ID: 442510 [Multi-domain]  Cd Length: 235  Bit Score: 80.25  E-value: 1.72e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490278289   1 MNAIIIDDHPLARIAIRNLLDS-NGITVAAELDSGAHAVQTAESMQPDLLIVDVDIPELSGIEVLEQLRKRRYQGTIIII 79
Cdd:COG3279    2 MKILIVDDEPLARERLERLLEKyPDLEVVGEASNGEEALELLEEHKPDLVFLDIQMPGLDGFELARQLRELDPPPPIIFT 81


                 ....*
gi 490278289  80 SAKNE 84
Cdd:COG3279   82 TAYDE 86
REC_YesN-like cd17536
phosphoacceptor receiver (REC) domain of YesN and related helix-turn-helix containing response ...
 4-81 3.15e-18

phosphoacceptor receiver (REC) domain of YesN and related helix-turn-helix containing response regulators; This family is composed of uncharacterized response regulators that contain a REC domain and a AraC family helix-turn-helix (HTH) DNA-binding output domain, including Bacillus subtilis uncharacterized transcriptional regulatory protein YesN and Staphylococcus aureus uncharacterized response regulatory protein SAR0214. YesN is a member of the two-component regulatory system YesM/YesN and SAR0214 is a member of the probable two-component regulatory system SAR0215/SAR0214. Also included in this family is the AlgR-like group of LytTR/AlgR family response, which includes Pseudomonas aeruginosa positive alginate biosynthesis regulatory protein AlgR and Bacillus subtilis sensory transduction protein LytT, among others. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381091 [Multi-domain]  Cd Length: 121  Bit Score: 76.61  E-value: 3.15e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490278289   4 IIIDDHPLARIAIRNLLD--SNGITVAAELDSGAHAVQTAESMQPDLLIVDVDIPELSGIEVLEQLRKRRYQGTIIIISA 81
Cdd:cd17536    2 LIVDDEPLIREGLKKLIDweELGFEVVGEAENGEEALELIEEHKPDIVITDIRMPGMDGLELIEKIRELYPDIKIIILSG 81
CitB COG4565
DNA-binding response regulator DpiB of citrate/malate metabolism [Transcription, Signal ...
 1-130 6.89e-18

DNA-binding response regulator DpiB of citrate/malate metabolism [Transcription, Signal transduction mechanisms];


Pssm-ID: 443622 [Multi-domain]  Cd Length: 138  Bit Score: 76.16  E-value: 6.89e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490278289   1 MNAIIIDDHPLARIAIRNLLDSN-GITVAAELDSGAHAVQTAESMQPDLLIVDVDIPELSGIEVLEQLRKRRYQGTIIII 79
Cdd:COG4565    4 IRVLIVEDDPMVAELLRRYLERLpGFEVVGVASSGEEALALLAEHRPDLILLDIYLPDGDGLELLRELRARGPDVDVIVI 83

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 490278289  80 SAKNELFYGKRSADCGANGFVSKkegmnnilaaidaanngysyfPFSLERF 130
Cdd:COG4565   84 TAARDPETVREALRAGVVDYLIK---------------------PFTFERL 113
REC_PdtaR-like cd19932
phosphoacceptor receiver (REC) domain of PdtaR and similar proteins; This subfamily includes ...
 1-116 7.03e-18

phosphoacceptor receiver (REC) domain of PdtaR and similar proteins; This subfamily includes Mycobacterium tuberculosis PdtaR, also called Rv1626, and similar proteins containing a REC domain and an ANTAR (AmiR and NasR transcription antitermination regulators) RNA-binding output domain. PdtaR is a response regulator that acts at the level of transcriptional antitermination and is a member of the PdtaR/PdtaS two-component regulatory system. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381159 [Multi-domain]  Cd Length: 118  Bit Score: 75.53  E-value: 7.03e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490278289   1 MNAIIIDDHPLARIAIRNLLDSNGITVAAELDSGAHAVQTAESMQPDLLIVDVDIPELSGIEVLEQLRKRRYqGTIIIIS 80
Cdd:cd19932    1 VRVLIAEDEALIRMDLREMLEEAGYEVVGEASDGEEAVELAKKHKPDLVIMDVKMPRLDGIEAAKIITSENI-APIVLLT 79

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 490278289  81 AKNELFYGKRSADCGANGFVSKKEGMNNILAAIDAA 116
Cdd:cd19932   80 AYSQQDLVERAKEAGAMAYLVKPFSESDLIPAIEMA 115
REC_NarL cd19931
phosphoacceptor receiver (REC) domain of Nitrate/Nitrite response regulator L (NarL); Nitrate ...
 4-102 2.12e-17

phosphoacceptor receiver (REC) domain of Nitrate/Nitrite response regulator L (NarL); Nitrate/nitrite response regulator protein NarL contains an N-terminal REC domain and a C-terminal LuxR family helix-turn-helix (HTH) DNA-binding output domain. Escherichia coli NarL activates the expression of the nitrate reductase (narGHJI) and formate dehydrogenase-N (fdnGHI) operons, and represses the transcription of the fumarate reductase (frdABCD) operon in response to a nitrate/nitrite induction signal. Phosphorylation of the NarL REC domain releases the C-terminal HTH output domain that subsequently binds specific DNA promoter sites to repress or activate gene expression. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381158 [Multi-domain]  Cd Length: 117  Bit Score: 74.31  E-value: 2.12e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490278289   4 IIIDDHPLARIAIRNLLDSN-GITVAAELDSGAHAVQTAESMQPDLLIVDVDIPELSGIEVLEQLRKRRYQGTIIIIS-- 80
Cdd:cd19931    2 LLIDDHPLLRKGIKQLIELDpDFTVVGEASSGEEGIELAERLDPDLILLDLNMKGMSGLDTLKALREEGVSARIVILTvs 81

                         90       100
                 ....*....|....*....|...
gi 490278289  81 -AKNELFygkRSADCGANGFVSK 102
Cdd:cd19931   82 dAEDDVV---TALRAGADGYLLK 101
AmiR COG3707
Two-component response regulator, AmiR/NasT family, consists of REC and RNA-binding ...
 1-116 4.44e-17

Two-component response regulator, AmiR/NasT family, consists of REC and RNA-binding antiterminator (ANTAR) domains [Signal transduction mechanisms, Transcription];


Pssm-ID: 442921 [Multi-domain]  Cd Length: 194  Bit Score: 75.38  E-value: 4.44e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490278289   1 MNAIIIDDHPLARIAIRNLLDSNGITVAAELDSGAHAVQTAESMQPDLLIVDVDIPELSGIEVLEQLRKRRyQGTIIIIS 80
Cdd:COG3707    4 LRVLVVDDEPLRRADLREGLREAGYEVVAEAADGEDAVELVRELKPDLVIVDIDMPDRDGLEAARQISEER-PAPVILLT 82

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 490278289  81 AKNELFYGKRSADCGANGFVSKKEGMNNILAAIDAA 116
Cdd:COG3707   83 AYSDPELIERALEAGVSAYLVKPLDPEDLLPALELA 118
RpfG COG3437
Response regulator c-di-GMP phosphodiesterase, RpfG family, contains REC and HD-GYP domains ...
 1-102 3.05e-16

Response regulator c-di-GMP phosphodiesterase, RpfG family, contains REC and HD-GYP domains [Signal transduction mechanisms];


Pssm-ID: 442663 [Multi-domain]  Cd Length: 224  Bit Score: 74.05  E-value: 3.05e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490278289   1 MNAIIIDDHPLARIAIRNLLDSNGITVAaELDSGAHAVQTAESMQPDLLIVDVDIPELSGIEVLEQLRKR-RYQGT-III 78
Cdd:COG3437    7 PTVLIVDDDPENLELLRQLLRTLGYDVV-TAESGEEALELLLEAPPDLILLDVRMPGMDGFELLRLLRADpSTRDIpVIF 85

                         90       100
                 ....*....|....*....|....
gi 490278289  79 ISAKNELFYGKRSADCGANGFVSK 102
Cdd:COG3437   86 LTALADPEDRERALEAGADDYLTK 109
REC_DesR-like cd19930
phosphoacceptor receiver (REC) domain of DesR and similar proteins; This group is composed of ...
 4-102 3.68e-15

phosphoacceptor receiver (REC) domain of DesR and similar proteins; This group is composed of Bacillus subtilis DesR, Streptococcus pneumoniae response regulator spr1814, and similar proteins, all containing an N-terminal REC domain and a C-terminal LuxR family helix-turn-helix (HTH) DNA-binding output domain. DesR is a response regulator that, together with its cognate sensor kinase DesK, comprises a two-component regulatory system that controls membrane fluidity. Phosphorylation of the REC domain of DesR is allosterically coupled to two distinct exposed surfaces of the protein, controlling noncanonical dimerization/tetramerization, cooperative activation, and DesK binding. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381157 [Multi-domain]  Cd Length: 117  Bit Score: 68.45  E-value: 3.68e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490278289   4 IIIDDHPLARIAIRNLLDSNG-ITVAAELDSGAHAVQTAESMQPDLLIVDVDIPELSGIEVLEQLRKRRYQGTIIIISAK 82
Cdd:cd19930    2 LIAEDQEMVRGALAALLELEDdLEVVAQASNGQEALRLVLKHSPDVAILDIEMPGRTGLEVAAELREELPDTKVLIVTTF 81

                         90       100
                 ....*....|....*....|
gi 490278289  83 NELFYGKRSADCGANGFVSK 102
Cdd:cd19930   82 GRPGYFRRALAAGVDGYVLK 101
REC_OmpR cd17574
phosphoacceptor receiver (REC) domain of OmpR family response regulators; OmpR-like proteins ...
 5-102 8.81e-15

phosphoacceptor receiver (REC) domain of OmpR family response regulators; OmpR-like proteins are one of the most widespread transcriptional regulators. OmpR family members contain REC and winged helix-turn-helix (wHTH) DNA-binding output effector domain. They are involved in the control of environmental stress tolerance (such as the oxidative, osmotic and acid stress response), motility, virulence, outer membrane biogenesis and other processes. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381116 [Multi-domain]  Cd Length: 99  Bit Score: 67.05  E-value: 8.81e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490278289   5 IIDDHPLARIAIRNLLDSNGITVAAELDsGAHAVQTAESMQPDLLIVDVDIPELSGIEVLEQLRKRRYQGTIIIISAKNE 84
Cdd:cd17574    2 VVEDDEEIAELLSDYLEKEGYEVDTAAD-GEEALELAREEQPDLIILDVMLPGMDGFEVCRRLREKGSDIPIIMLTAKDE 80

                         90
                 ....*....|....*...
gi 490278289  85 LFYGKRSADCGANGFVSK 102
Cdd:cd17574   81 EEDKVLGLELGADDYITK 98
Spo0F COG5803
Stage 0 sporulation initiation response regulator Spo0F [Cell cycle control, cell division, ...
 5-102 8.89e-15

Stage 0 sporulation initiation response regulator Spo0F [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];


Pssm-ID: 444505 [Multi-domain]  Cd Length: 119  Bit Score: 67.51  E-value: 8.89e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490278289   5 IIDDHPLARIAIRNLLDSNGITV-AAEldSGAHAVQTAESMQPDLLIVDVDIPELSGIEVLEQLRKRRYQGTIIIISAKN 83
Cdd:COG5803    7 IVDDQAGIRMLLKEVLKKEGYEVfQAA--NGKEALEKVKELKPDLVLLDMKMPGMDGIEILKEIKEIDPDIPVIMMTAYG 84

                         90
                 ....*....|....*....
gi 490278289  84 ELFYGKRSADCGANGFVSK 102
Cdd:COG5803   85 ELDMVEEAKELGAKGYFTK 103
AtoC COG2204
DNA-binding transcriptional response regulator, NtrC family, contains REC, AAA-type ATPase, ...
 5-116 4.76e-14

DNA-binding transcriptional response regulator, NtrC family, contains REC, AAA-type ATPase, and a Fis-type DNA-binding domains [Signal transduction mechanisms];


Pssm-ID: 441806 [Multi-domain]  Cd Length: 418  Bit Score: 69.61  E-value: 4.76e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490278289   5 IIDDHPLARIAIRNLLDSNGITVAaELDSGAHAVQTAESMQPDLLIVDVDIPELSGIEVLEQLRKRRYQGTIIIISAKNE 84
Cdd:COG2204    7 VVDDDPDIRRLLKELLERAGYEVE-TAASGEEALALLREEPPDLVLLDLRMPGMDGLELLRELRALDPDLPVILLTGYGD 85

                         90       100       110
                 ....*....|....*....|....*....|..
gi 490278289  85 LFYGKRSADCGANGFVSKKEGMNNILAAIDAA 116
Cdd:COG2204   86 VETAVEAIKAGAFDYLTKPFDLEELLAAVERA 117
fixJ PRK09390
response regulator FixJ; Provisional
 5-204 1.93e-13

response regulator FixJ; Provisional


Pssm-ID: 181815 [Multi-domain]  Cd Length: 202  Bit Score: 65.79  E-value: 1.93e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490278289   5 IIDDHPLARIAIRNLLDSNGITVAAeLDSGAHAVQTAESMQPDLLIVDVDIPELSGIEVLEQLRKRRYQGTIIIISAKNE 84
Cdd:PRK09390   8 VVDDDEAMRDSLAFLLDSAGFEVRL-FESAQAFLDALPGLRFGCVVTDVRMPGIDGIELLRRLKARGSPLPVIVMTGHGD 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490278289  85 LFYGKRSADCGANGFVSKKEGMNNILAAIDAAnngysyFPFSLERFCTHGITDQ--DRLDTLSTQEMKVFRYILSGVDYT 162
Cdd:PRK09390  87 VPLAVEAMKLGAVDFIEKPFEDERLIGAIERA------LAQAPEAAKSEAVAADirARIASLSERERQVMDGLVAGLSNK 160

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|..
gi 490278289 163 TIGSKMNISNKTVSTYKVRLMDKLGCSTLLELYDFAQRNKIG 204
Cdd:PRK09390 161 VIARDLDISPRTVEVYRANVMTKMQAGSLSELVRMALRAGRG 202
REC_LytTR_AlgR-like cd17532
phosphoacceptor receiver (REC) domain of LytTR/AlgR family response regulators similar to AlgR; ...
 3-81 2.31e-13

phosphoacceptor receiver (REC) domain of LytTR/AlgR family response regulators similar to AlgR; Members of the LytTR/AlgR family of response regulators contain a REC domain and a unique LytTR DNA-binding output domain that lacks the helix-turn-helix motif and consists mostly of beta-strands. Transcriptional regulators with the LytTR-type output domains are involved in biosynthesis of extracellular polysaccharides, fimbriation, expression of exoproteins, including toxins, and quorum sensing. Included in this AlgR-like group of LytTR/AlgR family response regulators are Streptococcus agalactiae sensory transduction protein LytR, Pseudomonas aeruginosa positive alginate biosynthesis regulatory protein AlgR, Bacillus subtilis sensory transduction protein LytT, and Escherichia coli transcriptional regulatory protein BtsR, which are members of two-component regulatory systems. LytR and LytT are components of regulatory systems that regulate genes involved in cell wall metabolism. AlgR positively regulates the algD gene, which codes for a GDP-mannose dehydrogenase, a key enzyme in the alginate biosynthesis pathway. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381087 [Multi-domain]  Cd Length: 118  Bit Score: 63.71  E-value: 2.31e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490278289   3 AIIIDDHPLARIAIRNLL-DSNGITVAAELDSGAHAVQTAESMQPDLLIVDVDIPELSGIEVLEQLRKRRYQGTIIIISA 81
Cdd:cd17532    1 ALIVDDEPLAREELRYLLeEHPDIEIVGEAENGEEALEAIEELKPDVVFLDIQMPGLDGLELAKKLSKLAKPPLIVFVTA 80
REC_RpfG-like cd17551
phosphoacceptor receiver (REC) domain of cyclic di-GMP phosphodiesterase response regulator ...
 1-102 4.87e-13

phosphoacceptor receiver (REC) domain of cyclic di-GMP phosphodiesterase response regulator RpfG and similar proteins; Cyclic di-GMP phosphodiesterase response regulator RpfG, together with sensory/regulatory protein RpfC, constitute a two-component system implicated in sensing and responding to the diffusible signal factor (DSF) that is essential for cell-cell signaling. RpfC is a hybrid sensor/histidine kinase that phosphorylates and activates RpfG, which degrades cyclic di-GMP to GMP, leading to the activation of Clp, a global transcriptional regulator that regulates a large set of genes in the DSF pathway. RpfG contains a CheY-like receiver domain attached to a histidine-aspartic acid-glycine-tyrosine-proline (HD-GYP) cyclic di-GMP phosphodiesterase domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381103 [Multi-domain]  Cd Length: 118  Bit Score: 62.84  E-value: 4.87e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490278289   1 MNAIIIDDHPLARIAIRNLLDS-NGITVAAELDSGAhAVQTAESMQPDLLIVDVDIPELSGIEVLEQLRKRRYQGT--II 77
Cdd:cd17551    1 MRILIVDDNPTNLLLLEALLRSaGYLEVVSFTDPRE-ALAWCRENPPDLILLDYMMPGMDGLEFIRRLRALPGLEDvpIV 79

                         90       100
                 ....*....|....*....|....*...
gi 490278289  78 IISAKN--ELfygKRSA-DCGANGFVSK 102
Cdd:cd17551   80 MITADTdrEV---RLRAlEAGATDFLTK 104
REC_CheY cd17542
phosphoacceptor receiver (REC) domain of chemotaxis protein CheY; The chemotaxis response ...
 1-102 8.21e-13

phosphoacceptor receiver (REC) domain of chemotaxis protein CheY; The chemotaxis response regulator CheY contains a stand-alone REC domain. Chemotaxis is a behavior known for motile bacteria that directs their movement in response to chemical gradients. CheY is involved in transmitting sensory signals from chemoreceptors to the flagellar motors. Phosphorylated CheY interacts with the flagella switch components FliM and FliY, which causes counterclockwise rotation of the flagella, resulting in smooth swimming. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381097 [Multi-domain]  Cd Length: 117  Bit Score: 62.30  E-value: 8.21e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490278289   1 MNAIIIDDHPLARIAIRNLLDSNGITVAAELDSGAHAVQTAESMQPDLLIVDVDIPELSGIEVLEQLRKRRYQGTIIIIS 80
Cdd:cd17542    1 KKVLIVDDAAFMRMMLKDILTKAGYEVVGEAANGEEAVEKYKELKPDLVTMDITMPEMDGIEALKEIKKIDPNAKVIMCS 80

                         90       100
                 ....*....|....*....|....
gi 490278289  81 A--KNELFygKRSADCGANGFVSK 102
Cdd:cd17542   81 AmgQEEMV--KEAIKAGAKDFIVK 102
REC_CheC-like cd17593
phosphoacceptor receiver (REC) domain of uncharacterized response regulators containing a CheC ...
 1-102 1.92e-12

phosphoacceptor receiver (REC) domain of uncharacterized response regulators containing a CheC domain; This subfamily is composed of uncharacterized proteins containing an N-terminal REC domain and a C-terminal CheC domain that may function as the output/effector domain of a response regulator. CheC is a CheY-P phosphatase, affecting the level of phosphorylated CheY which controls the sense of flagella rotation and determine swimming behavior of chemotactic bacteria. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381124 [Multi-domain]  Cd Length: 117  Bit Score: 61.40  E-value: 1.92e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490278289   1 MNAIIIDDHPLARIAI-RNLLDSNGITVA-AEldSGAHAVQTAESMQPDLLIVDVDIPELSGIEVLEQLRKRRYQGTIII 78
Cdd:cd17593    1 MKVLICDDSSMARKQLaRALPADWDVEITfAE--NGEEALEILREGRIDVLFLDLTMPVMDGYEVLEALPVEQLETKVIV 78

                         90       100       110
                 ....*....|....*....|....*....|
gi 490278289  79 IS------AKnelfygKRSADCGANGFVSK 102
Cdd:cd17593   79 VSgdvqpeAK------ERVLELGALAFLKK 102
PRK10840 PRK10840
transcriptional regulator RcsB; Provisional
 1-187 2.27e-12

transcriptional regulator RcsB; Provisional


Pssm-ID: 182771 [Multi-domain]  Cd Length: 216  Bit Score: 63.31  E-value: 2.27e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490278289   1 MNAIIIDDHPLARIAIRNLLDS-NGITVAAELDSGAHAVQTAESMQPDLLIVDVDIPEL---SGIEVLEQLRKRRYQGTI 76
Cdd:PRK10840   4 MNVIIADDHPIVLFGIRKSLEQiEWVNVVGEFEDSTALINNLPKLDAHVLITDLSMPGDkygDGITLIKYIKRHFPSLSI 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490278289  77 IIISAKNELFYGKRSADCGANGFVSKKEGMNNILAAIDAANNGYSYFPFS----LERFCTHGITDQdrldTLSTQEMKVF 152
Cdd:PRK10840  84 IVLTMNNNPAILSAVLDLDIEGIVLKQGAPTDLPKALAALQKGKKFTPESvsrlLEKISAGGYGDK----RLSPKESEVL 159

                        170       180       190
                 ....*....|....*....|....*....|....*
gi 490278289 153 RYILSGVDYTTIGSKMNISNKTVSTYKVRLMDKLG 187
Cdd:PRK10840 160 RLFAEGFLVTEIAKKLNRSIKTISSQKKSAMMKLG 194
HTH_LUXR smart00421
helix_turn_helix, Lux Regulon; lux regulon (activates the bioluminescence operon
 141-198 5.27e-12

helix_turn_helix, Lux Regulon; lux regulon (activates the bioluminescence operon


Pssm-ID: 197715 [Multi-domain]  Cd Length: 58  Bit Score: 58.31  E-value: 5.27e-12
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 490278289   141 LDTLSTQEMKVFRYILSGVDYTTIGSKMNISNKTVSTYKVRLMDKLGCSTLLELYDFA 198
Cdd:smart00421   1 LASLTPREREVLRLLAEGLTNKEIAERLGISEKTVKTHLSNIMRKLGVRSRTQAVRLA 58
REC_citrate_TCS cd19925
phosphoacceptor receiver (REC) domain of citrate family two-component system response ...
 4-85 7.59e-12

phosphoacceptor receiver (REC) domain of citrate family two-component system response regulators; This family includes Lactobacillus paracasei MaeR, Escherichia coli DcuR and DpiA, Klebsiella pneumoniae CitB, as well as Bacillus DctR, MalR, and CitT. These are all response regulators of two-component systems (TCSs) from the citrate family, and are involved in the transcriptional regulation of genes associated with L-malate catabolism (MaeRK), citrate-specific fermentation (DpiAB, CitAB), plasmid inheritance (DpiAB), anaerobic fumarate respiratory system (DcuRS), and malate transport/utilization (MalKR). REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381152 [Multi-domain]  Cd Length: 118  Bit Score: 59.95  E-value: 7.59e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490278289   4 IIIDDHPLARIAIRNLLDSNGITVAAELDSGAHAVQTAESMQPDLLIVDVDIPELSGIEVLEQLRKRRYQGTIIIISAKN 83
Cdd:cd19925    5 IVEDDPMVAEIHRAYVEQVPGFTVIGTAGTGEEALKLLKERQPDLILLDIYLPDGNGLDLLRELRAAGHDVDVIVVTAAN 84


                 ..
gi 490278289  84 EL 85
Cdd:cd19925   85 DV 86
REC_OmpR_YycF-like cd17614
phosphoacceptor receiver (REC) domain of YrcF-like OmpR family response regulators; YycF ...
 4-115 2.49e-11

phosphoacceptor receiver (REC) domain of YrcF-like OmpR family response regulators; YycF appears to play an important role in cell wall integrity in a wide range of gram-positive bacteria, and may also modulate cell membrane integrity. It functions as part of a phosphotransfer system that ultimately controls the levels of competence within the bacteria. YycF belongs to the OmpR family of response regulators, which are characterized by a REC domain and a winged helix-turn-helix effector domain involved in DNA binding. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381130 [Multi-domain]  Cd Length: 115  Bit Score: 58.20  E-value: 2.49e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490278289   4 IIIDDHPLARIaIRNLLDSNGITVAAELDsGAHAVQTAESMQPDLLIVDVDIPELSGIEVLEQLRKrRYQGTIIIISAKN 83
Cdd:cd17614    3 VVDDEKPISDI-LKFNLTKEGYEVVTAYD-GREALEKVEEEQPDLILLDLMLPEKDGLEVCREVRK-TSNVPIIMLTAKD 79

                         90       100       110
                 ....*....|....*....|....*....|..
gi 490278289  84 ELFYGKRSADCGANGFVSKKEGMNNILAAIDA 115
Cdd:cd17614   80 SEVDKVLGLELGADDYVTKPFSNRELLARVKA 111
REC_CheY_CheY3 cd19923
phosphoacceptor receiver (REC) domain of chemotaxis response regulator CheY3 and similar CheY ...
 1-126 2.86e-11

phosphoacceptor receiver (REC) domain of chemotaxis response regulator CheY3 and similar CheY family proteins; CheY family chemotaxis response regulators (RRs) comprise about 17% of bacterial RRs and almost half of all RRs in archaea. This subfamily contains Vibrio cholerae CheY3, Escherichia coli CheY, and similar CheY family RRs. CheY proteins control bacterial motility and participate in signaling phosphorelays and in protein-protein interactions. CheY RRs contain only the REC domain with no output/effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381150 [Multi-domain]  Cd Length: 119  Bit Score: 58.12  E-value: 2.86e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490278289   1 MNAIIIDDHPLARIAIRNLLDSNGITVAAELDSGAHAVQTAESMQPDLLIVDVDIPELSGIEVLEQLRKRRYQGTIIIIS 80
Cdd:cd19923    1 MKVLVVDDFSTMRRIIKNLLKELGFNNVEEAEDGVDALEKLKAGGFDFVITDWNMPNMDGLELLKTIRADGALSHLPVLM 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 490278289  81 AKNElfygkrsadcgangfvSKKEgmnNILAAIDAANNGYSYFPFS 126
Cdd:cd19923   81 VTAE----------------AKKE---NVIAAAQAGVNNYIVKPFT 107
REC_OmpR_PrrA-like cd17627
phosphoacceptor receiver (REC) domain of PrrA-like OmpR family response regulators; The ...
 4-115 2.88e-11

phosphoacceptor receiver (REC) domain of PrrA-like OmpR family response regulators; The Mycobacterium tuberculosis PrrA is part of the PrrA/PrrB two-component system (TCS) that has been implicated in early intracellular multiplication and is essential for viability. Also included in this subfamily is Mycobacterium tuberculosis MprA, part of the MprAB TCS that regulates EspR, a key regulator of the ESX-1 secretion system, and is required for establishment and maintenance of persistent infection in a tissue- and stage-specific fashion. PrrA and MprA belong to the OmpR family of DNA-binding response regulators, which contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381142 [Multi-domain]  Cd Length: 116  Bit Score: 58.16  E-value: 2.88e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490278289   4 IIIDDHPLARIAIRNLLDSNGITVAAELDsGAHAVQTAESMQPDLLIVDVDIPELSGIEVLEQLRKRRYQGTIIIISAKN 83
Cdd:cd17627    2 LVVDDDRAVRESLRRSLRFEGYEVETAVD-GAEALRVISGNRPDAVVLDVMMPRLDGLEVCRRLRAAGNDLPILVLTARD 80

                         90       100       110
                 ....*....|....*....|....*....|....
gi 490278289  84 ELfyGKRSA--DCGANGFVSKKEGMNNILAAIDA 115
Cdd:cd17627   81 SV--SDRVAglDAGADDYLVKPFALEELLARVRA 112
REC_RssB-like cd17555
phosphoacceptor receiver (REC) domain of Pseudomonas aeruginosa RssB and similar domains; ...
 5-83 2.91e-11

phosphoacceptor receiver (REC) domain of Pseudomonas aeruginosa RssB and similar domains; Pseudomonas aeruginosa RssB is an orphan atypical response regulator containing a REC domain and a PP2C-type protein phosphatase output domain. Its function is still unknown. Escherichia RssB, which is not included in this subfamily, is a ClpX adaptor protein which alters ClpX specificity by mediating a specific interaction between ClpX and the substrates such as RpoS, an RNA polymerase sigma factor. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381107 [Multi-domain]  Cd Length: 116  Bit Score: 57.98  E-value: 2.91e-11
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 490278289   5 IIDDHPLARIAIRNLLDSNGITVAaELDSGAHAVQTAESMQPDLLIVDVDIPELSGIEVLEQLRKRRYQGTIIIISAKN 83
Cdd:cd17555    5 VIDDDEVVRESIAAYLEDSGFQVL-QAADGRQGLELFRSEQPDLVLCDLRMPEMDGLEVLKQITKESPDTPVIVVSGAG 82
REC_OmpR_KdpE-like cd17620
phosphoacceptor receiver (REC) domain of KdpE-like OmpR family response regulators; KdpE is a ...
 5-102 4.26e-11

phosphoacceptor receiver (REC) domain of KdpE-like OmpR family response regulators; KdpE is a component of the KdpD/KdpE two-component system (TCS) and is activated when histidine kinase KdpD senses a drop in external K+ concentration or upshift in ionic osmolarity, resulting in the expression of a heterooligomeric transporter KdpFABC. In addition, the KdpD/KdpE TCS is also an adaptive regulator involved in the virulence and intracellular survival of pathogenic bacteria. KdpE is a member of the OmpR family of DNA-binding response regulators that contain REC and winged helix-turn-helix (wHTH) DNA-binding output effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381135 [Multi-domain]  Cd Length: 99  Bit Score: 57.17  E-value: 4.26e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490278289   5 IIDDHPLARIAIRNLLDSNGITVAaELDSGAHAVQTAESMQPDLLIVDVDIPELSGIEVLEQLRKrRYQGTIIIISAKNE 84
Cdd:cd17620    3 VIEDEPQIRRFLRTALEAHGYRVF-EAETGQEGLLEAATRKPDLIILDLGLPDMDGLEVIRRLRE-WSAVPVIVLSARDE 80

                         90
                 ....*....|....*...
gi 490278289  85 LFYGKRSADCGANGFVSK 102
Cdd:cd17620   81 ESDKIAALDAGADDYLTK 98
REC_FixJ cd17537
phosphoacceptor receiver (REC) domain of FixJ family response regulators; FixJ family response ...
 5-116 6.71e-11

phosphoacceptor receiver (REC) domain of FixJ family response regulators; FixJ family response regulators contain an N-terminal receiver domain (REC) and a C-terminal LuxR family helix-turn-helix (HTH) DNA-binding output domain. The Sinorhizobium meliloti two-component system FixL/FixJ regulates nitrogen fixation in response to oxygen during symbiosis. Under microaerobic conditions, the kinase FixL phosphorylates the response regulator FixJ resulting in the regulation of nitrogen fixation genes such as nifA and fixK. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381092 [Multi-domain]  Cd Length: 116  Bit Score: 57.22  E-value: 6.71e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490278289   5 IIDDHPLARIAIRNLLDSNGITVAAeLDSGAHAVQTAESMQPDLLIVDVDIPELSGIEVLEQLRKRRYQGTIIIISAKNE 84
Cdd:cd17537    5 VVDDDEAVRDSLAFLLRSVGLAVKT-FTSASAFLAAAPPDQPGCLVLDVRMPGMSGLELQDELLARGSNIPIIFITGHGD 83

                         90       100       110
                 ....*....|....*....|....*....|..
gi 490278289  85 LFYGKRSADCGANGFVSKKEGMNNILAAIDAA 116
Cdd:cd17537   84 VPMAVEAMKAGAVDFLEKPFRDQVLLDAIEQA 115
LuxR_C_like cd06170
C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix ...
 144-200 1.32e-10

C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many are active as homodimers. Many are two domain proteins in which the DNA binding property of the C-terminal DNA binding domain is modulated by modifications of the N-terminal domain. For example in the case of Lux R which participates in the regulation of gene expression in response to fluctuations in cell-population density (quorum-sensing), a signaling molecule, the pheromone Acyl HSL (N-acyl derivatives of homoserine lactone), binds to the N-terminal domain and leads to LuxR dimerization. For others phophorylation of the N-terminal domain leads to multimerization, for example Escherichia coli NarL and Sinorhizobium melilot FixJ. NarL controls gene expression of many respiratory-related operons when environmental nitrate or nitrite is present under anerobic conditions. FixJ is involved in the transcriptional activation of nitrogen fixation genes. The group also includes small proteins which lack an N-terminal signaling domain, such as Bacillus subtilis GerE. GerE is dimeric and acts in conjunction with sigmaK as an activator or a repressor modulating the expression of various genes in particular those encoding the spore-coat. These LuxR family regulators may share a similar organization of their target binding sites. For example the LuxR dimer binds the lux box, a 20bp inverted repeat, GerE dimers bind two 12bp consensus sequences in inverted orientation having the central four bases overlap, and the NarL dimer binds two 7bp inverted repeats separated by 2 bp.


Pssm-ID: 99777 [Multi-domain]  Cd Length: 57  Bit Score: 54.85  E-value: 1.32e-10
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 490278289 144 LSTQEMKVFRYILSGVDYTTIGSKMNISNKTVSTYKVRLMDKLGCSTLLELYDFAQR 200
Cdd:cd06170    1 LTPREREVLRLLAEGKTNKEIADILGISEKTVKTHLRNIMRKLGVKSRTQLVAYAIR 57
GerE pfam00196
Bacterial regulatory proteins, luxR family;
142-198 1.60e-10

Bacterial regulatory proteins, luxR family;


Pssm-ID: 425517 [Multi-domain]  Cd Length: 57  Bit Score: 54.51  E-value: 1.60e-10
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 490278289  142 DTLSTQEMKVFRYILSGVDYTTIGSKMNISNKTVSTYKVRLMDKLGCSTLLELYDFA 198
Cdd:pfam00196   1 DSLSPREREVLRWLAAGKSNKEIADELGISEKTVKVHRSNIMRKLNVHSRVELVRMA 57
REC_2_DhkD-like cd17580
second phosphoacceptor receiver (REC) domain of Dictyostelium discoideum hybrid signal ...
 5-79 1.71e-10

second phosphoacceptor receiver (REC) domain of Dictyostelium discoideum hybrid signal transduction histidine kinase D and similar domains; Dictyostelium discoideum hybrid signal transduction histidine kinase D (DhkD) is a large protein that contains two histidine kinase (HK) and two REC domains on the intracellular side of a single pass transmembrane domain, and extracellular PAS and PAC domains that likely are involved in ligand binding. This model represents the second REC domain and similar domains. DhkD activates the cAMP phosphodiesterase RegA to ensure proper prestalk and prespore patterning, tip formation, and the vertical elongation of the mound into a finger, in Dictyostelium discoideum. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381118 [Multi-domain]  Cd Length: 112  Bit Score: 55.93  E-value: 1.71e-10
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 490278289   5 IIDDHPLARIAIRNLLDSNGITVAAeLDSGAHAVQTAESMQPDLLIVDVDIPELSGIEVLEQLRKRRYQGTIIII 79
Cdd:cd17580    3 VVDDNEDAAEMLALLLELEGAEVTT-AHSGEEALEAAQRFRPDVILSDIGMPGMDGYELARRLRELPWLANTPAI 76
REC_PatA-like cd17602
phosphoacceptor receiver (REC) domain of PatA and similar domains; Nostoc sp. (or Anabaena sp.) ...
 6-102 1.90e-10

phosphoacceptor receiver (REC) domain of PatA and similar domains; Nostoc sp. (or Anabaena sp.) PatA is necessary for proper patterning of heterocysts along filaments. PatA contains phosphoacceptor REC domain at its C-terminus and an N-terminal PATAN (PatA N-terminus) domain, which was proposed in a bioinformatics study to mediate protein-protein interactions. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays. Some members of this group may have an inactive REC domain, lacking canonical metal-binding and active site residues.


Pssm-ID: 381129 [Multi-domain]  Cd Length: 102  Bit Score: 55.45  E-value: 1.90e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490278289   6 IDDHPLARIAIRNLLDSNGITVAAeLDSGAHAVQTAESMQPDLLIVDVDIPELSGIEVLEQLRKRRY--QGTIIIISAKN 83
Cdd:cd17602    4 VDDRPSIQKMIEYFLEKQGFRVVV-IDDPLRALTTLLNSKPDLILIDIDMPDLDGYELCSLLRKSSAlkDTPIIMLTGKD 82

                         90
                 ....*....|....*....
gi 490278289  84 ELFYGKRSADCGANGFVSK 102
Cdd:cd17602   83 GLVDRIRAKMAGASGYLTK 101
REC_PA4781-like cd19920
phosphoacceptor receiver (REC) domain of cyclic di-GMP phosphodiesterase PA4781 and similar ...
 5-86 1.93e-10

phosphoacceptor receiver (REC) domain of cyclic di-GMP phosphodiesterase PA4781 and similar domains; Pseudomonas aeruginosa cyclic di-GMP phosphodiesterase PA4781 contains an N-terminal REC domain and a C-terminal catalytic HD-GYP domain, characteristics of RpfG family response regulators. PA4781 is involved in cyclic di-3',5'-GMP (c-di-GMP) hydrolysis/degradation in a two-step reaction via the linear intermediate pGpG to produce GMP. Its unphosphorylated REC domain prevents accessibility of c-di-GMP to the active site. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381147 [Multi-domain]  Cd Length: 103  Bit Score: 55.59  E-value: 1.93e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490278289   5 IIDDHPLARIAIRNLLDSNGITVAAELDsGAHAVQTAESMQPDLLIVDVDIPELSGIEVLEQLRKR-RYQGT-IIIISAK 82
Cdd:cd19920    3 IVDDVPDNLRLLSELLRAAGYRVLVATD-GQQALQRAQAEPPDLILLDVMMPGMDGFEVCRRLKADpATRHIpVIFLTAL 81


                 ....
gi 490278289  83 NELF 86
Cdd:cd19920   82 TDTE 85
REC_D1_PleD-like cd17538
first (D1) phosphoacceptor receiver (REC) domain of response regulator PleD and similar ...
 4-102 3.79e-10

first (D1) phosphoacceptor receiver (REC) domain of response regulator PleD and similar domains; PleD contains a REC domain (D1) with the phosphorylatable aspartate, a REC-like adaptor domain (D2), and the enzymatic diguanylate cyclase (DGC) domain, also called the GGDEF domain according to a conserved sequence motif, as its output domain. The GGDEF-containing PleD response regulators are global regulators of cell metabolism in some important human pathogens. This model describes D1 of PleD and similar domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381093 [Multi-domain]  Cd Length: 104  Bit Score: 54.81  E-value: 3.79e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490278289   4 IIIDDHPLARIAIRNLLDSNGITVAaELDSGAHAVQTAESMQPDLLIVDVDIPELSGIEVLEQLRKRRYQGTI--IIISA 81
Cdd:cd17538    3 LVVDDEPANRELLEALLSAEGYEVL-TADSGQEALALAEEELPDLILLDVMMPGMDGFEVCRRLKEDPETRHIpvIMITA 81

                         90       100
                 ....*....|....*....|.
gi 490278289  82 KNELFYGKRSADCGANGFVSK 102
Cdd:cd17538   82 LDDREDRIRGLEAGADDFLSK 102
REC_CheB-like cd17541
phosphoacceptor receiver (REC) domain of chemotaxis response regulator protein-glutamate ...
 5-81 7.07e-10

phosphoacceptor receiver (REC) domain of chemotaxis response regulator protein-glutamate methylesterase CheB and similar chemotaxis proteins; Methylesterase CheB is a chemotaxis response regulator with an N-terminal REC domain and a C-terminal methylesterase domain. Chemotaxis is a behavior known in motile bacteria that directs their movement in response to chemical gradients. CheB is a phosphorylation-activated response regulator involved in the reversible modification of bacterial chemotaxis receptors. It catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR. The CheB REC domain packs against the active site of the C-terminal domain and inhibits methylesterase activity by directly restricting access to the active site. Also included in this family is chemotaxis response regulator CheY, which contains a stand-alone REC domain, and an uncharacterized subfamily composed of proteins containing an N-terminal REC domain and a C-terminal CheY-P phosphatase (CheC) domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381096 [Multi-domain]  Cd Length: 125  Bit Score: 54.71  E-value: 7.07e-10
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 490278289   5 IIDDHPLARIAIRNLLDSN-GITVAAELDSGAHAVQTAESMQPDLLIVDVDIPELSGIEVLEQLRKRRyqGT-IIIISA 81
Cdd:cd17541    5 IVDDSAVMRKLLSRILESDpDIEVVGTARDGEEALEKIKELKPDVITLDIEMPVMDGLEALRRIMAER--PTpVVMVSS 81
REC_OmpR_BsPhoP-like cd19937
phosphoacceptor receiver (REC) domain of BsPhoP-like OmpR family response regulators; Bacillus ...
 5-86 1.07e-09

phosphoacceptor receiver (REC) domain of BsPhoP-like OmpR family response regulators; Bacillus subtilis PhoP (BsPhoP) is part of the PhoPR two-component system that participates in a signal transduction network that controls adaptation of the bacteria to phosphate deficiency by regulating (activating or repressing) genes of the Pho regulon upon phosphorylation by PhoR. When activated, PhoPR directs expression of phosphate scavenging enzymes, lowers synthesis of the phosphate-rich wall teichoic acid (WTA) and initiates synthesis of teichuronic acid, a non-phosphate containing replacement anionic polymer. Members of this subfamily belong to the OmpR family of DNA-binding response regulators, which are characterized by a REC domain and a winged helix-turn-helix (wHTH) DNA-binding output effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381164 [Multi-domain]  Cd Length: 116  Bit Score: 53.82  E-value: 1.07e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490278289   5 IIDDHPlariAIRNLLDSN----GITVAAELDsGAHAVQTAESMQPDLLIVDVDIPELSGIEVLEQLRK-RRYQGT-III 78
Cdd:cd19937    2 VVDDEE----DIVELLKYNlekeGYEVVTAYD-GEEALKRAKDEKPDLIILDLMLPGIDGLEVCRILRSdPKTSSIpIIM 76


                 ....*...
gi 490278289  79 ISAKNELF 86
Cdd:cd19937   77 LTAKGEEF 84
REC_GlnL-like cd17565
phosphoacceptor receiver (REC) domain of transcriptional regulatory protein GlnL and similar ...
 5-80 1.19e-09

phosphoacceptor receiver (REC) domain of transcriptional regulatory protein GlnL and similar proteins; Bacillus subtilis GlnL is part of the GlnK-GlnL (formerly YcbA-YcbB) two-component system that positively regulates the expression of the glsA-glnT (formerly ybgJ-ybgH) operon in response to glutamine. It contains a REC domain and a DNA-binding output domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381112 [Multi-domain]  Cd Length: 103  Bit Score: 53.43  E-value: 1.19e-09
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 490278289   5 IIDDHPLARIAIRNLL--DSNGiTVAAELDSGAHAVQTAESMQPDLLIVDVDIPELSGIEVLEQLRKRRYQGTIIIIS 80
Cdd:cd17565    3 IVDDDKNIIKILSDIIedDDLG-EVVGEADNGAQAYDEILFLQPDIVLIDLLMPGMDGIQLVRKLKDTGSNGKFIMIS 79
PRK10693 PRK10693
two-component system response regulator RssB;
29-85 1.67e-09

two-component system response regulator RssB;


Pssm-ID: 182652 [Multi-domain]  Cd Length: 303  Bit Score: 56.15  E-value: 1.67e-09
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 490278289  29 AELDSGAHAVQTAESMQPDLLIVDVDIPELSGIEVLEQLRKRRYQGTIIIISAKNEL 85
Cdd:PRK10693   1 VLAANGVDALELLGGFTPDLIICDLAMPRMNGIEFVEHLRNRGDQTPVLVISATENM 57
CsgD COG2771
DNA-binding transcriptional regulator, CsgD family [Transcription];
127-203 1.78e-09

DNA-binding transcriptional regulator, CsgD family [Transcription];


Pssm-ID: 442052 [Multi-domain]  Cd Length: 188  Bit Score: 55.15  E-value: 1.78e-09
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 490278289 127 LERFCTHGITDQDRLDTLSTQEMKVFRYILSGVDYTTIGSKMNISNKTVSTYKVRLMDKLGCSTLLELYDFAQRNKI 203
Cdd:COG2771  111 AALLLAALARLLARAPGLTPREREVLRLLAEGLTLKEIARILGISERTVRTHLKRIYRKLGVSSRAELVALALRLGL 187
REC_CheV-like cd19924
phosphoacceptor receiver (REC) domain of chemotaxis protein CheV and similar proteins; This ...
 3-102 2.35e-09

phosphoacceptor receiver (REC) domain of chemotaxis protein CheV and similar proteins; This subfamily includes the REC domains of Bacillus subtilis chemotaxis protein CheV, Myxococcus xanthus gliding motility regulatory protein FrzE, and similar proteins. CheV is a hybrid protein with an N-terminal CheW-like domain and a C-terminal CheY-like REC domain. The CheV pathway is one of three systems employed by B. subtilis for sensory adaptation that contribute to chemotaxis. It is involved in the transmission of sensory signals from chemoreceptors to flagellar motors. Together with CheW, it is involved in the coupling of methyl-accepting chemoreceptors to the central two-component histidine kinase CheA. FrzE is a hybrid sensor histidine kinase/response regulator that is part of the Frz pathway that controls cell reversal frequency to support directional motility during swarming and fruiting body formation. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381151 [Multi-domain]  Cd Length: 111  Bit Score: 52.77  E-value: 2.35e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490278289   3 AIIIDDHPLARIAIRNLLDSNGITVAAELD--SGAHAVQ------TAESMQPDLLIVDVDIPELSGIEVLEQLRK-RRYQ 73
Cdd:cd19924    1 ILVVDDSPTARKQLRDLLKNLGFEIAEAVDgeEALNKLEnlakegNDLSKELDLIITDIEMPKMDGYELTFELRDdPRLA 80

                         90       100       110
                 ....*....|....*....|....*....|
gi 490278289  74 GT-IIIISAKNELFYGKRSADCGANGFVSK 102
Cdd:cd19924   81 NIpVILNSSLSGEFSRARGKKVGADAYLAK 110
REC_OmpR_DrrD-like cd17625
phosphoacceptor receiver (REC) domain of DrrD-like OmpR family response regulators; DrrD is a ...
 5-115 2.72e-09

phosphoacceptor receiver (REC) domain of DrrD-like OmpR family response regulators; DrrD is a OmpR/PhoB homolog from Thermotoga maritima whose function is not yet known. This subfamily also includes Streptococcus agalactiae transcriptional regulatory protein DltR, part of the DltS/DltR two-component system (TCS), and Pseudomonas aeruginosa transcriptional activator protein PfeR, part of the PfeR/PfeS TCS, which activates expression of the ferric enterobactin receptor. The DltS/DltR TCS regulates the expression of the dlt operon, which comprises four genes (dltA, dltB, dltC, and dltD) that catalyze the incorporation of D-alanine residues into the lipoteichoic acids. Members of this subfamily belong to the OmpR/PhoB family, which comprises of two domains, an N-terminal receiver domain and a C-terminal DNA-binding winged helix-turn-helix effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381140 [Multi-domain]  Cd Length: 115  Bit Score: 52.99  E-value: 2.72e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490278289   5 IIDDHPLARIAIRNLLDSNGITVAAELDsGAHAVQTAESMQPDLLIVDVDIPELSGIEVLEQLRKRRYQGTIIIISAKNE 84
Cdd:cd17625    2 VVEDEKDLSEAITKHLKKEGYTVDVCFD-GEEGLEYALSGIYDLIILDIMLPGMDGLEVLKSLREEGIETPVLLLTALDA 80

                         90       100       110
                 ....*....|....*....|....*....|.
gi 490278289  85 LFYGKRSADCGANGFVSKKEGMNNILAAIDA 115
Cdd:cd17625   81 VEDRVKGLDLGADDYLPKPFSLAELLARIRA 111
REC_OmpR_CusR-like cd19935
phosphoacceptor receiver (REC) domain of CusR-like OmpR family response regulators; ...
 4-85 5.14e-09

phosphoacceptor receiver (REC) domain of CusR-like OmpR family response regulators; Escherichia coli CusR is part of the CusS/CusR two-component system (TCS) that is involved in response to copper and silver. Other members of this subfamily include Escherichia coli PcoR, Pseudomonas syringae CopR, and Streptomyces coelicolor CutR, which are all transcriptional regulatory proteins and components of TCSs that regulate genes involved in copper resistance and/or metabolism. member of the subfamily is Escherichia coli HprR (hydrogen peroxide response regulator), previously called YdeW, which is part of the HprSR (or YedVW) TCS involved in stress response to hydrogen peroxide, as well as Cupriavidus metallidurans CzcR, which is part of the CzcS/CzcR TCS involved in the control of cobalt, zinc, and cadmium homeostasis. Members of this subfamily belong to the OmpR family of DNA-binding response regulators, which contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381162 [Multi-domain]  Cd Length: 100  Bit Score: 51.67  E-value: 5.14e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490278289   4 IIIDDHPLARIAIRNLLDSNGITVAAELDsGAHAVQTAESMQPDLLIVDVDIPELSGIEVLEQLRKRRYQGTIIIISAKN 83
Cdd:cd19935    2 LVVEDEKKLAEYLKKGLTEEGYAVDVAYD-GEDGLHLALTNEYDLIILDVMLPGLDGLEVLRRLRAAGKQTPVLMLTARD 80


                 ..
gi 490278289  84 EL 85
Cdd:cd19935   81 SV 82
PRK11697 PRK11697
two-component system response regulator BtsR;
1-67 9.85e-09

two-component system response regulator BtsR;


Pssm-ID: 236956 [Multi-domain]  Cd Length: 238  Bit Score: 53.31  E-value: 9.85e-09
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 490278289   1 MNAIIIDDHPLARIAIRNLLDSNG-ITVAAELDSGAHAVQTAESMQPDLLIVDVDIPELSGIEVLEQL 67
Cdd:PRK11697   2 IKVLIVDDEPLAREELRELLQEEGdIEIVGECSNAIEAIGAIHRLKPDVVFLDIQMPRISGLELVGML 69
REC_TrrA-like cd17554
phosphoacceptor receiver (REC) domain of Thermotoga maritima response regulator TrrA and ...
 5-84 1.17e-08

phosphoacceptor receiver (REC) domain of Thermotoga maritima response regulator TrrA and similar domains; Thermotoga maritima contains a two-component signal transduction system (TCS) composed of the ThkA sensory histidine kinase (HK) and its cognate response regulator (RR) TrrA; the specific function of the system is unknown. TCSs couple environmental stimuli to adaptive responses. TrrA is a stand-alone RR containing only a REC domain with no output/effector domain. The REC domain itself functions as an effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381106 [Multi-domain]  Cd Length: 113  Bit Score: 51.07  E-value: 1.17e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490278289   5 IIDDHPLARIAIRNLLDSNG--ITVAaelDSGAHAVQTAESMQPDLLIVDVDIPELSGIEVLEQLRKRRYQGTIIIISAK 82
Cdd:cd17554    5 VVDDEENIRELYKEELEDEGyeVVTA---GNGEEALEKLESEDPDLVILDIKMPGMDGLETLRKIREKKPDLPVIICTAY 81


                 ..
gi 490278289  83 NE 84
Cdd:cd17554   82 SE 83
REC_DC-like cd17534
phosphoacceptor receiver (REC) domain of modulated diguanylate cyclase and similar domains; ...
 5-116 1.31e-08

phosphoacceptor receiver (REC) domain of modulated diguanylate cyclase and similar domains; This groups includes a modulated diguanylate cyclase containing a PAS sensor domain from Desulfovibrio desulfuricans G20. Members of this group contain N-terminal REC domains and various output domains including the GGDEF, histidine kinase, and helix-turn-helix (HTH) DNA binding domains. Also included in this family is Mycobacterium tuberculosis PdtaR, a transcriptional antiterminator that contains a REC domain and an ANTAR RNA-binding output domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381089 [Multi-domain]  Cd Length: 117  Bit Score: 50.87  E-value: 1.31e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490278289   5 IIDDHPLARIAIRNLLDSNGITVAAELDSGAHAVQTAESMQPDLLIVDVDIP-ELSGIEVLEQLRKrRYQGTIIIISA-- 81
Cdd:cd17534    5 IVEDEAIIALDLKEILESLGYEVVGIADSGEEAIELAEENKPDLILMDINLKgDMDGIEAAREIRE-KFDIPVIFLTAys 83

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 490278289  82 KNELFygKRSADCGANGFVSKKEGMNNILAAIDAA 116
Cdd:cd17534   84 DEETL--ERAKETNPYGYLVKPFNERELKAAIELA 116
REC_Spo0A cd17561
phosphoacceptor receiver (REC) domain of Spo0A; Spo0A is a response regulator of the ...
 3-102 1.83e-08

phosphoacceptor receiver (REC) domain of Spo0A; Spo0A is a response regulator of the phosphorelay system in the early stage of spore formation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress and may act in the with sigma factor spo0H to control the expression of some genes that are critical to the sporulation process. Spo0A contains a regulatory N-terminal REC domain and a C-terminal DNA-binding transcription activation domain as its effector/output domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381109 [Multi-domain]  Cd Length: 108  Bit Score: 50.30  E-value: 1.83e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490278289   3 AIIIDDHPLARIAIRNLLDSNGITVAAELDSGAHAVQTAESMQPDLLIVDVDIPELSGIEVLEQLRKRR--YQGTIIIIS 80
Cdd:cd17561    5 LIADDNREFVQLLEEYLNSQPDMEVVGVAHNGQEALELIEEKEPDVLLLDIIMPHLDGIGVLEKLRRMRleKRPKIIMLT 84

                         90       100
                 ....*....|....*....|..
gi 490278289  81 AKNELFYGKRSADCGANGFVSK 102
Cdd:cd17561   85 AFGQEDITQRAVELGASYYILK 106
REC_OmpR_kpRstA-like cd17622
phosphoacceptor receiver (REC) domain of kpRstA-like OmpR family response regulators; ...
 7-102 2.17e-08

phosphoacceptor receiver (REC) domain of kpRstA-like OmpR family response regulators; Klebsiella pneumoniae RstA (kpRstA) is part of the RstA/RstB two-component regulatory system that may play a regulatory role in virulence. It belongs to the OmpR family of DNA-binding response regulators that contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381137 [Multi-domain]  Cd Length: 116  Bit Score: 50.45  E-value: 2.17e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490278289   7 DDHPLARIaIRNLLDSNGITVAAELDsGAHAVQTAESMQPDLLIVDVDIPELSGIEVLEQLRkRRYQGTIIIISAKNELF 86
Cdd:cd17622    8 DDPKLARL-IADFLESHGFNVVVEHR-GDRALEVIAREKPDAVLLDIMLPGIDGLTLCRDLR-PKYQGPILLLTALDSDI 84

                         90
                 ....*....|....*.
gi 490278289  87 YGKRSADCGANGFVSK 102
Cdd:cd17622   85 DHILGLELGADDYVVK 100
REC smart00448
cheY-homologous receiver domain; CheY regulates the clockwise rotation of E. coli flagellar ...
 1-56 2.35e-08

cheY-homologous receiver domain; CheY regulates the clockwise rotation of E. coli flagellar motors. This domain contains a phosphoacceptor site that is phosphorylated by histidine kinase homologues.


Pssm-ID: 214668 [Multi-domain]  Cd Length: 55  Bit Score: 48.72  E-value: 2.35e-08
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 490278289     1 MNAIIIDDHPLARIAIRNLLDSNGITVaAELDSGAHAVQTAESMQPDLLIVDVDIP 56
Cdd:smart00448   1 MRILVVDDDPLLRELLKALLEKEGYEV-DEATDGEEALELLKEEKPDLILLDIMMP 55
REC_CpdR_CckA-like cd18160
phosphoacceptor receiver (REC) domain of Brucella abortus CpdR and CckA, and similar domains; ...
 4-102 2.58e-08

phosphoacceptor receiver (REC) domain of Brucella abortus CpdR and CckA, and similar domains; Two-component systems (TCSs), consisting of a sensor and a response regulator, are used by bacteria to adapt to changing environments. Processes regulated by TCSs in bacteria include sporulation, pathogenicity, virulence, chemotaxis and membrane transport. Response regulators share the common phosphoacceptor REC domain and differ output domains such as DNA, RNA, ligand, and protein-binding, or enzymatic domain. CpdR is a stand-alone REC protein. CckA is a sensor histidine kinase containing N-terminal PAS domains and a C-terminal REC domain. CpdR and CckA are components of a regulatory phosphorelay system (composed of CckA, ChpT, CtrA and CpdR) that controls Brucella abortus cell growth, division, and intracellular survival inside mammalian host cells. CckA autophosphorylates in the presence of ATP and transfers a phosphoryl group to the conserved aspartic acid residue on its C-terminal REC domain, which is relayed to the ChpT phosphotransferase. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381144 [Multi-domain]  Cd Length: 103  Bit Score: 49.81  E-value: 2.58e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490278289   4 IIIDDHPLARIAIRNLLDSNGITVAaELDSGAHAVQTAESMQP-DLLIVDVDIPELSGIEVLEQLRKRRYQGTIIIISAK 82
Cdd:cd18160    3 LLADDEPSVRKFIVTTLKKAGYAVT-EAESGAEALEKLQQGKDiDIVVTDIVMPEMDGIELAREARKIDPDVKILFISGG 81

                         90       100
                 ....*....|....*....|
gi 490278289  83 NELFYGKRSADCGANGFVSK 102
Cdd:cd18160   82 AAAAPELLSDAVGDNATLKK 101
REC_OmpR_MtPhoP-like cd17615
phosphoacceptor receiver (REC) domain of MtPhoP-like OmpR family response regulators; ...
 3-85 3.19e-08

phosphoacceptor receiver (REC) domain of MtPhoP-like OmpR family response regulators; Mycobacterium tuberculosis PhoP (MtPhoP) is part of the PhoP/PhoR two-component system that is involved in phosphate control by stimulating expression of genes involved in scavenging, transport and mobilization of phosphate, and repressing the utilization of nitrogen sources. Also included in this subfamily is Mycobacterium tuberculosis transcriptional regulatory protein TcrX, part of the two-component regulatory system TcrY/TcrX that may be involved in virulence. Members of this subfamily belong to the OmpR family of DNA-binding response regulators, which are characterized by a REC domain and a winged helix-turn-helix (wHTH) DNA-binding output effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381131 [Multi-domain]  Cd Length: 118  Bit Score: 50.04  E-value: 3.19e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490278289   3 AIIIDDHPlariAIRNLLDSN----GITVAAELDsGAHAVQTAESMQPDLLIVDVDIPELSGIEVLEQLRKRRYQGTIII 78
Cdd:cd17615    2 VLVVDDEP----NITELLSMAlryeGWDVETAAD-GAEALAAAREFRPDAVVLDIMLPDMDGLEVLRRLRADGPDVPVLF 76


                 ....*..
gi 490278289  79 ISAKNEL 85
Cdd:cd17615   77 LTAKDSV 83
PRK10610 PRK10610
chemotaxis protein CheY;
1-126 3.31e-08

chemotaxis protein CheY;


Pssm-ID: 170568 [Multi-domain]  Cd Length: 129  Bit Score: 50.36  E-value: 3.31e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490278289   1 MNAIIIDDHPLARIAIRNLLDSNGITVAAELDSGAHAVQTAESMQPDLLIVDVDIPELSGIEVLEQLRKRRYQGTIIIIS 80
Cdd:PRK10610   6 LKFLVVDDFSTMRRIVRNLLKELGFNNVEEAEDGVDALNKLQAGGFGFVISDWNMPNMDGLELLKTIRADGAMSALPVLM 85

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 490278289  81 AKNElfygkrsadcgangfvSKKEgmnNILAAIDAANNGYSYFPFS 126
Cdd:PRK10610  86 VTAE----------------AKKE---NIIAAAQAGASGYVVKPFT 112
REC_CheY4-like cd17562
phosphoacceptor receiver (REC) domain of chemotaxis response regulator CheY4 and similar CheY ...
 5-102 3.41e-08

phosphoacceptor receiver (REC) domain of chemotaxis response regulator CheY4 and similar CheY family proteins; CheY family chemotaxis response regulators (RRs) comprise about 17% of bacterial RRs and almost half of all RRs in archaea. This subfamily contains Vibrio cholerae CheY4 and similar CheY family RRs. CheY proteins control bacterial motility and participate in signaling phosphorelays and in protein-protein interactions. CheY RRs contain only the REC domain with no output/effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381110 [Multi-domain]  Cd Length: 118  Bit Score: 49.99  E-value: 3.41e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490278289   5 IIDDHPLARIAIRNLLDSNGITVAAELDsGAHAVQTAESMQPDLLIVDVDIPELSGIEVLEQLRKR-RYQGTIIII---- 79
Cdd:cd17562    5 AVDDSASIRQMVSFTLRGAGYEVVEAAD-GRDALSKAQSKKFDLIITDQNMPNMDGIELIKELRKLpAYKFTPILMltte 83

                         90       100
                 ....*....|....*....|....*.
gi 490278289  80 ---SAKNElfyGKrsaDCGANGFVSK 102
Cdd:cd17562   84 ssdEKKQE---GK---AAGATGWLVK 103
PRK10529 PRK10529
DNA-binding transcriptional activator KdpE; Provisional
 2-116 3.59e-08

DNA-binding transcriptional activator KdpE; Provisional


Pssm-ID: 182522 [Multi-domain]  Cd Length: 225  Bit Score: 51.73  E-value: 3.59e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490278289   2 NAIIIDDHPLARIAIRNLLDSNGITVAaELDSGAHAVQTAESMQPDLLIVDVDIPELSGIEVLEQLRKRRyQGTIIIISA 81
Cdd:PRK10529   3 NVLIVEDEQAIRRFLRTALEGDGMRVF-EAETLQRGLLEAATRKPDLIILDLGLPDGDGIEFIRDLRQWS-AIPVIVLSA 80

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 490278289  82 KNELFYGKRSADCGANGFVSKKEGMNNILAAIDAA 116
Cdd:PRK10529  81 RSEESDKIAALDAGADDYLSKPFGIGELQARLRVA 115
REC_OmpR_CpxR cd17623
phosphoacceptor receiver (REC) domain of CpxR-like OmpR family response regulators; CpxR is ...
 4-84 4.52e-08

phosphoacceptor receiver (REC) domain of CpxR-like OmpR family response regulators; CpxR is part of the CpxA/CpxR two-component regulatory system that mediates envelope stress responses that is key for virulence and antibiotic resistance in several Gram negative pathogens. CpxR is a transcription factor/response regulator that controls the expression of numerous genes, including those of the classical porins OmpF and OmpC. It belongs to the OmpR family of DNA-binding response regulators that contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381138 [Multi-domain]  Cd Length: 115  Bit Score: 49.61  E-value: 4.52e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490278289   4 IIIDDHPLARIaIRNLLDSNGITVAAELDsGAHAVQTAESMQPDLLIVDVDIPELSGIEVLEQLRKrRYQGTIIIISAKN 83
Cdd:cd17623    3 LIDDDRELTEL-LTEYLEMEGFNVRAAHD-GEQGLAALLEGSPDLVVLDVMLPKMNGLDVLKELRK-TSQVPVLMLTARG 79


                 .
gi 490278289  84 E 84
Cdd:cd17623   80 D 80
PRK11361 PRK11361
acetoacetate metabolism transcriptional regulator AtoC;
4-102 7.50e-08

acetoacetate metabolism transcriptional regulator AtoC;


Pssm-ID: 183099 [Multi-domain]  Cd Length: 457  Bit Score: 51.77  E-value: 7.50e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490278289   4 IIIDDHPLARIAIRNLLDSNGITVAAELDsGAHAVQTAESMQPDLLIVDVDIPELSGIEVLEQLRKRRYQGTIIIISAKN 83
Cdd:PRK11361   8 LIVDDEDNVRRMLSTAFALQGFETHCANN-GRTALHLFADIHPDVVLMDIRMPEMDGIKALKEMRSHETRTPVILMTAYA 86

                         90
                 ....*....|....*....
gi 490278289  84 ELFYGKRSADCGANGFVSK 102
Cdd:PRK11361  87 EVETAVEALRCGAFDYVIK 105
REC_NtrC cd19919
phosphoacceptor receiver (REC) domain of DNA-binding transcriptional regulator NtrC; ...
 5-85 8.77e-08

phosphoacceptor receiver (REC) domain of DNA-binding transcriptional regulator NtrC; DNA-binding transcriptional regulator NtrC is also called nitrogen regulation protein NR(I) or nitrogen regulator I (NRI). It contains an N-terminal receiver (REC) domain, followed by a sigma-54 interaction domain, and a C-terminal helix-turn-helix DNA-binding domain. It is part of the two-component regulatory system NtrB/NtrC, which controls expression of the nitrogen-regulated (ntr) genes in response to nitrogen limitation. DNA-binding response regulator NtrC is phosphorylated by NtrB; phosphorylation of the N-terminal REC domain activates the central sigma-54 interaction domain and leads to the transcriptional activation from promoters that require sigma(54)-containing RNA polymerase. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381146 [Multi-domain]  Cd Length: 116  Bit Score: 48.81  E-value: 8.77e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490278289   5 IIDDHPLARIAIRNLLDSNGITVAAeLDSGAHAVQTAESMQPDLLIVDVDIPELSGIEVLEQLRKRRYQGTIIIISAKNE 84
Cdd:cd19919    5 IVDDDSSIRWVLERALAGAGLTVTS-FENAQEALAALASSQPDVLISDIRMPGMDGLALLAQIKQRHPDLPVIIMTAHSD 83


                 .
gi 490278289  85 L 85
Cdd:cd19919   84 L 84
REC_OmpR_BfmR-like cd19939
phosphoacceptor receiver (REC) domain of BfmR-like OmpR family response regulators; ...
 4-84 9.15e-08

phosphoacceptor receiver (REC) domain of BfmR-like OmpR family response regulators; Acinetobacter baumannii BfmR is part of the BfmR/S two-component system that functions as the master regulator of biofilm initiation. BfmR confers resistance to complement-mediated bactericidal activity, independent of capsular polysaccharide, and also increases resistance to the clinically important antimicrobials meropenem and colistin, making it a potential antimicrobial target. Its inhibition would have the dual benefit of significantly decreasing in vivo survival and increasing sensitivity to selected antimicrobials. Members of this subfamily belong to the OmpR family of DNA-binding response regulators, which are characterized by a REC domain and a winged helix-turn-helix (wHTH) DNA-binding output effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381166 [Multi-domain]  Cd Length: 116  Bit Score: 48.91  E-value: 9.15e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490278289   4 IIIDDHPLARIaIRNLLDSNGITVAAELDsGAHAVQTAESMQPDLLIVDVDIPELSGIEVLEQLRKRRYQgTIIIISAKN 83
Cdd:cd19939    4 IVEDELELARL-TRDYLIKAGLEVSVFTD-GQRAVRRIIDEQPSLVVLDIMLPGMDGLTVCREVREHSHV-PILMLTART 80


                 .
gi 490278289  84 E 84
Cdd:cd19939   81 E 81
PRK00742 PRK00742
chemotaxis-specific protein-glutamate methyltransferase CheB;
1-79 1.35e-07

chemotaxis-specific protein-glutamate methyltransferase CheB;


Pssm-ID: 234828 [Multi-domain]  Cd Length: 354  Bit Score: 50.53  E-value: 1.35e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490278289   1 MNAI---IIDDHPLARIAIRNLLDSN-GITVAAELDSGAHAVQTAESMQPDLLIVDVDIPELSGIEVLEQL-RKRRyqgT 75
Cdd:PRK00742   1 MMKIrvlVVDDSAFMRRLISEILNSDpDIEVVGTAPDGLEAREKIKKLNPDVITLDVEMPVMDGLDALEKImRLRP---T 77


                 ....
gi 490278289  76 IIII 79
Cdd:PRK00742  78 PVVM 81
REC_DivK-like cd17548
phosphoacceptor receiver (REC) domain of DivK and similar proteins; Caulobacter crescentus ...
 5-69 1.63e-07

phosphoacceptor receiver (REC) domain of DivK and similar proteins; Caulobacter crescentus DivK is an essential response regulator that is involved in the complex phosphorelay pathways controlling both cell division and motility. It localizes cell cycle regulators to specific poles of the cell during division. DivK contains a stand-alone REC domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381100 [Multi-domain]  Cd Length: 115  Bit Score: 47.92  E-value: 1.63e-07
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 490278289   5 IIDDHPLARIAIRNLLDSNGITVAaELDSGAHAVQTAESMQPDLLIVDVDIPELSGIEVLEQLRK 69
Cdd:cd17548    4 IVEDNPLNMKLARDLLESAGYEVL-EAADGEEALEIARKEKPDLILMDIQLPGMDGLEATRLLKE 67
REC_NtrC1-like cd17572
phosphoacceptor receiver (REC) domain of nitrogen regulatory protein C 1 (NtrC1) from Aquifex ...
 32-81 2.92e-07

phosphoacceptor receiver (REC) domain of nitrogen regulatory protein C 1 (NtrC1) from Aquifex aeolicus and similar NtrC family response regulators; NtrC family proteins are transcriptional regulators that have REC, AAA+ ATPase/sigma-54 interaction, and DNA-binding output domains. This subfamily of NtrC proteins include Aquifex aeolicus NtrC1 and Vibrio quorum-sensing signal integrator LuxO. The N-terminal REC domain of NtrC proteins regulate the activity of the protein and its phosphorylation controls the AAA+ domain oligomerization, while the central AAA+ domain participates in nucleotide binding, hydrolysis, oligomerization, and sigma54 interaction. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381114 [Multi-domain]  Cd Length: 121  Bit Score: 47.58  E-value: 2.92e-07
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|
gi 490278289  32 DSGAHAVQTAESMQPDLLIVDVDIPELSGIEVLEQLRKRRYQGTIIIISA 81
Cdd:cd17572   29 ETGKEALAFLSDQPPDVVLLDLKLPDMSGMEILKWIQERSLPTSVIVITA 78
REC_2_GGDEF cd17544
second phosphoacceptor receiver (REC) domain of uncharacterized GGDEF domain proteins; This ...
 5-102 4.38e-07

second phosphoacceptor receiver (REC) domain of uncharacterized GGDEF domain proteins; This family is composed of uncharacterized PleD-like response regulators that contain two N-terminal REC domains and a C-terminal diguanylate cyclase output domain with the characteristic GGDEF motif at the active site. Unlike PleD which contains a REC-like adaptor domain, the second REC domain of these uncharacterized GGDEF domain proteins, described in this model, contains characteristic metal-binding and active site residues. PleD response regulators are global regulators of cell metabolism in some important human pathogens. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381098 [Multi-domain]  Cd Length: 122  Bit Score: 47.13  E-value: 4.38e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490278289   5 IIDDHPLARIAIRNLLDSNGITVAaELDSGAHAVQTAESmQPD--LLIVDVDIPELSGIEVLEQLRKR--RYQGTIIIIS 80
Cdd:cd17544    5 VVDDSATSRNHLRALLRRHNFQVL-EAANGQEALEVLEQ-HPDikLVITDYNMPEMDGFELVREIRKKysRDQLAIIGIS 82

                         90       100
                 ....*....|....*....|..
gi 490278289  81 AKNELFYGKRSADCGANGFVSK 102
Cdd:cd17544   83 ASGDNALSARFIKAGANDFLTK 104
PRK09959 PRK09959
acid-sensing system histidine kinase EvgS;
1-97 4.69e-07

acid-sensing system histidine kinase EvgS;


Pssm-ID: 182169 [Multi-domain]  Cd Length: 1197  Bit Score: 49.35  E-value: 4.69e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490278289    1 MNAIIIDDHPLARIAIRNLLDSNGITVAAELDsGAHAVQTAESMQPDLLIVDVDIPELSGIEVLEQLRKRRYQGTIIIIS 80
Cdd:PRK09959  959 LSILIADDHPTNRLLLKRQLNLLGYDVDEATD-GVQALHKVSMQHYDLLITDVNMPNMDGFELTRKLREQNSSLPIWGLT 1037

                          90
                  ....*....|....*..
gi 490278289   81 AKNELFYGKRSADCGAN 97
Cdd:PRK09959 1038 ANAQANEREKGLSCGMN 1054
REC_RR468-like cd17552
phosphoacceptor receiver (REC) domain of Thermotoga maritima response regulator RR468 and ...
 5-68 7.85e-07

phosphoacceptor receiver (REC) domain of Thermotoga maritima response regulator RR468 and similar domains; Thermotoga maritima RR468 (encoded by gene TM0468) is the cognate response regulator (RR) of the class I histidine kinase HK853 (product of gene TM0853). HK853/RR468 comprise a two-component system (TCS) that couples environmental stimuli to adaptive responses. This subfamily also includes Fremyella diplosiphon complementary adaptation response regulator homolog RcaF, a small RR that is involved in four-step phosphorelays of the complementary chromatic adaptation (CCA) system that occurs in many cyanobacteria. Both RR468 and RcaF are stand-alone RRs containing only a REC domain with no output/effector domain. The REC domain itself functions as an effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381104 [Multi-domain]  Cd Length: 121  Bit Score: 46.39  E-value: 7.85e-07
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 490278289   5 IIDDHPLARIAIR-NLLDSNGITVAAElDSGAHAVQTAESMQPDLLIVDVDIPELSGIEVLEQLR 68
Cdd:cd17552    6 VIDDEEDIREVVQaCLEKLAGWEVLTA-SSGQEGLEKAATEQPDAILLDVMMPDMDGLATLKKLQ 69
REC_OmpR_PhoB cd17618
phosphoacceptor receiver (REC) domain of PhoB response regulator from the OmpR family; The ...
 4-115 8.66e-07

phosphoacceptor receiver (REC) domain of PhoB response regulator from the OmpR family; The transcription factor PhoB is a component of the PhoR/PhoB two-component system, a key regulatory protein network that facilitates response to inorganic phosphate (Pi) starvation conditions by turning on the phosphate (pho) regulon whose products are involved in phosphorus uptake and metabolism. PhoB is a member of the OmpR family of DNA-binding response regulators that contains REC and winged helix-turn-helix (wHTH) DNA-binding output effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381133 [Multi-domain]  Cd Length: 118  Bit Score: 46.09  E-value: 8.66e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490278289   4 IIIDDHPLARIAIRNLLDSNGITVAaELDSGAHAVQTAESMQPDLLIVDVDIPELSGIEVLEQLRKR-RYQGT-IIIISA 81
Cdd:cd17618    4 LIVEDEPAIREMIAFNLERAGFDVV-EAEDAESAVNLIVEPRPDLILLDWMLPGGSGIQFIRRLKRDeMTRDIpIIMLTA 82

                         90       100       110
                 ....*....|....*....|....*....|....
gi 490278289  82 KNELFYGKRSADCGANGFVSKKEGMNNILAAIDA 115
Cdd:cd17618   83 RGEEEDKVRGLEAGADDYITKPFSPRELVARIKA 116
COG4567 COG4567
DNA-binding response regulator, ActR/RegA family, consists of REC and Fis-type HTH domains ...
 4-80 1.11e-06

DNA-binding response regulator, ActR/RegA family, consists of REC and Fis-type HTH domains [Signal transduction mechanisms, Transcription];


Pssm-ID: 443624 [Multi-domain]  Cd Length: 177  Bit Score: 46.83  E-value: 1.11e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 490278289   4 IIIDDHPLARIAIRnLLDSNGITVAAeLDSGAHAVQTAESMQPDLLIVDVDIPELSGIEVLEQLRKRRYQGTIIIIS 80
Cdd:COG4567    9 LVDDDEAFARVLAR-ALERRGFEVTT-AASVEEALALLEQAPPDYAVLDLRLGDGSGLDLIEALRERDPDARIVVLT 83
REC_NtrX-like cd17550
phosphoacceptor receiver (REC) domain of nitrogen assimilation regulatory protein NtrX and ...
 5-80 1.43e-06

phosphoacceptor receiver (REC) domain of nitrogen assimilation regulatory protein NtrX and similar proteins; NtrX is part of the two-component regulatory system NtrY/NtrX that is involved in the activation of nitrogen assimilatory genes such as Gln. It is phosphorylated by the histidine kinase NtrY and interacts with sigma-54. NtrX is a member of the NtrC family, characterized by a domain architecture containing an N-terminal REC domain, followed by a central sigma-54 interaction/ATPase domain, and a C-terminal DNA binding domain. NtrC family response regulators are sigma54-dependent transcriptional activators. Also included in this subfamily is Aquifex aeolicus NtrC4. The ability of the central domain to hydrolyze ATP and thus to interact effectively with a complex of RNA polymerase, sigma54, and promoter, is controlled by the phosphorylation status of the REC domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381102 [Multi-domain]  Cd Length: 115  Bit Score: 45.57  E-value: 1.43e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 490278289   5 IIDDHPLARIAIRNLLDSNGITVAAELDsGAHAVQTAESMQPDLLIVDVDIPELSGIEVLEQLRKRRYQGTIIIIS 80
Cdd:cd17550    3 IVDDEEDIRESLSGILEDEGYEVDTAAD-GEEALKLIKERRPDLVLLDIWLPDMDGLELLKEIKEKYPDLPVIMIS 77
REC_OmpR_PmrA-like cd17624
phosphoacceptor receiver (REC) domain of PmrA-like OmpR family response regulators; This ...
 4-85 1.44e-06

phosphoacceptor receiver (REC) domain of PmrA-like OmpR family response regulators; This subfamily contains various OmpR family response regulators including PmrA, BasR, QseB, tctD, and RssB, which are components of two-component regulatory systems (TCSs). The PmrA/PmrB TCS controls transcription of genes that are involved in lipopolysaccharide modification in the outer membrane of bacteria, increasing bacterial resistance to host-derived antimicrobial peptides. The BasS/BasR TCS functions as an iron- and zinc-sensing transcription regulator. The QseB/QseC TCS activates the flagella regulon by activating transcription of FlhDC. The RssA/RssB TCS regulates swarming behavior in Serratia marcescens. OmpR family DNA-binding response regulators contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381139 [Multi-domain]  Cd Length: 115  Bit Score: 45.55  E-value: 1.44e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490278289   4 IIIDDHPLARIAIRNLLDSNGITVAaELDSGAHAVQTAESMQPDLLIVDVDIPELSGIEVLEQLRKRRYQGTIIIISAKN 83
Cdd:cd17624    2 LLVEDDALLGDGLKTGLRKAGYAVD-WVRTGAEAEAALASGPYDLVILDLGLPDGDGLDLLRRWRRQGQSLPVLILTARD 80


                 ..
gi 490278289  84 EL 85
Cdd:cd17624   81 GV 82
REC_RcNtrC-like cd19928
phosphoacceptor receiver (REC) domain of Rhodobacter capsulatus nitrogen regulatory protein C ...
 15-102 1.94e-06

phosphoacceptor receiver (REC) domain of Rhodobacter capsulatus nitrogen regulatory protein C (NtrC) and similar NtrC family response regulators; NtrC family proteins are transcriptional regulators that have REC, AAA+ ATPase/sigma-54 interaction, and DNA-binding output domains. This subfamily of NtrC proteins include NtrC, also called nitrogen regulator I (NRI), from Rhodobacter capsulatus, Azospirillum brasilense, and Azorhizobium caulinodans. NtrC is part of the NtrB/NtrC two-component system that controls the expression of the nitrogen-regulated (ntr) genes in response to nitrogen limitation. The N-terminal REC domain of NtrC proteins regulate the activity of the protein and its phosphorylation controls the AAA+ domain oligomerization, while the central AAA+ domain participates in nucleotide binding, hydrolysis, oligomerization, and sigma54 interaction. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381155 [Multi-domain]  Cd Length: 100  Bit Score: 44.80  E-value: 1.94e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490278289  15 AIRNLLDSNGITVAAELDSGAHAV---QTAESMQPDLLIVDVDIPELSGIEVLEQLRKRRYQGTIIIISAKNELFYGKRS 91
Cdd:cd19928    9 AIRTVLTQALGRAGYEVRTTGNAAtlwRWVEEGEGDLVITDVVMPDENGLDLIPRIKKARPDLPIIVMSAQNTLMTAVKA 88

                         90
                 ....*....|.
gi 490278289  92 ADCGANGFVSK 102
Cdd:cd19928   89 AERGAFEYLPK 99
REC_ETR-like cd19933
phosphoacceptor receiver (REC) domain of plant ethylene receptors ETR1, ETR2, and EIN4, and ...
 4-102 2.03e-06

phosphoacceptor receiver (REC) domain of plant ethylene receptors ETR1, ETR2, and EIN4, and similar proteins; Plant ethylene receptors contain N-terminal transmembrane domains that contain an ethylene binding site and also serve in localization of the receptor to the endoplasmic reticulum or the Golgi apparatus and a C-terminal histidine kinase (HK)-like domain. There are five ethylene receptors (ETR1, ERS1, ETR2, ERS2, and EIN4) in Arabidopsis thaliana. ETR1, ETR2, and EIN4 also contain REC domains C-terminal to the HK domain. ETR1 and ERS1 belong to subfamily 1, and have functional HK domains while ETR2, ERS2, and EIN4 belong to subfamily 2, and lack the necessary residues for HK activity and may function as serine/threonine kinases. The plant hormone ethylene plays an important role in plant growth and development. It regulates seed germination, seedling growth, leaf and petal abscission, fruit ripening, organ senescence, and pathogen responses. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381160 [Multi-domain]  Cd Length: 117  Bit Score: 45.08  E-value: 2.03e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490278289   4 IIIDDHPLARIAIRNLLDSNGITVAAeLDSGAHAVQT--AESMQPDLLIVDVDIPELSGIEVLEQLRKRRYQGT---III 78
Cdd:cd19933    4 LLVDDNAVNRMVTKGLLEKLGCEVTT-VSSGEECLNLlaSAEHSFQLVLLDLCMPEMDGFEVALRIRKLFGRRErplIVA 82

                         90       100
                 ....*....|....*....|....
gi 490278289  79 ISAKNELFYGKRSADCGANGFVSK 102
Cdd:cd19933   83 LTANTDDSTREKCLSLGMNGVITK 106
REC_Ycf29 cd19927
phosphoacceptor receiver (REC) domain of probable transcriptional regulator Ycf29; Ycf29 is a ...
 4-102 2.21e-06

phosphoacceptor receiver (REC) domain of probable transcriptional regulator Ycf29; Ycf29 is a probable response regulator of a two-component system (TCS), typically consisting a sensor and a response regulator, that functions in adaptation to changing environments. Processes regulated by TCSs in bacteria include sporulation, pathogenicity, virulence, chemotaxis, and membrane transport. Ycf29 contains an N-terminal REC domain and a LuxR-type helix-turn-helix DNA-binding output domain. REC domains function as phosphorylation-mediated switches within RRs, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381154 [Multi-domain]  Cd Length: 102  Bit Score: 44.68  E-value: 2.21e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490278289   4 IIIDDHPLARIAIRNLLDSNGITVAAELdSGAHAVQTAESMQPDLLIVDVDIPELSGIEVLEQLRKRRYQGTI--IIISA 81
Cdd:cd19927    2 LLVDDDPGIRLAVKDYLEDQGFTVIAAS-NGLEALDLLNQYIPDLIISDIIMPGVDGYSLLGKLRKNADFDTIpvIFLTA 80

                         90       100
                 ....*....|....*....|.
gi 490278289  82 KNELFYGKRSADCGANGFVSK 102
Cdd:cd19927   81 KGMTSDRIKGYNAGCDGYLSK 101
REC_RegA-like cd17563
phosphoacceptor receiver (REC) domain of photosynthetic apparatus regulatory protein RegA; ...
 4-78 2.56e-06

phosphoacceptor receiver (REC) domain of photosynthetic apparatus regulatory protein RegA; Rhodobacter sphaeroides RegA, also called response regulator PrrA, is the DNA binding regulatory protein of a redox-responsive two-component regulatory system RegB/RegA that is involved in transactivating anaerobic expression of the photosynthetic apparatus. It contains a REC domain and a DNA-binding helix-turn-helix output domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381111 [Multi-domain]  Cd Length: 112  Bit Score: 44.74  E-value: 2.56e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 490278289   4 IIIDDHPLARIAIRNLlDSNGITVAAElDSGAHAVQTAESMQPDLLIVDVDIPELSGIEVLEQLRKRRYQGTIII 78
Cdd:cd17563    5 LVDDDEVFAERLARAL-ERRGFEVETA-HSVEEALALAREEKPDYAVLDLRLGGDSGLDLIPPLRALQPDARIVV 77
REC_Spo0F-like cd17553
phosphoacceptor receiver (REC) domain of Spo0F and similar domains; Spo0F, a stand-alone ...
 4-113 3.13e-06

phosphoacceptor receiver (REC) domain of Spo0F and similar domains; Spo0F, a stand-alone response regulator containing only a REC domain with no output/effector domain, controls sporulation in Bacillus subtilis through the exchange of a phosphoryl group. Bacillus subtilis forms spores when conditions for growth become unfavorable. The initiation of sporulation is controlled by a phosphorelay (an expanded version of the two-component system) that consists of four main components: a histidine kinase (KinA), a secondary messenger (Spo0F), a phosphotransferase (Spo0B), and a transcription factor (Spo0A). REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381105 [Multi-domain]  Cd Length: 117  Bit Score: 44.47  E-value: 3.13e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490278289   4 IIIDDHPLARIAIRNLLDSNGITVAaELDSGAHAVQTAESMQPDLLIVDVDIPELSGIEVLEQLRKRRYQGTIIIISAKN 83
Cdd:cd17553    4 LIVDDQYGIRILLNEVFNKEGYQTF-QAANGLQALDIVTKERPDLVLLDMKIPGMDGIEILKRMKVIDENIRVIIMTAYG 82

                         90       100       110
                 ....*....|....*....|....*....|
gi 490278289  84 ELFYGKRSADCGANGFVSKKEGMNNILAAI 113
Cdd:cd17553   83 ELDMIQESKELGALTHFAKPFDIDEIRDAV 112
REC_OmpR_CtrA cd17616
phosphoacceptor receiver (REC) domain of CtrA-like OmpR family response regulators; CtrA is ...
 4-115 4.47e-06

phosphoacceptor receiver (REC) domain of CtrA-like OmpR family response regulators; CtrA is part of the CckA-ChpT-CtrA phosphorelay that is conserved in alphaproteobacteria and is important in orchestrating the cell cycle, polar development, and flagellar biogenesis. CtrA is the master regulator of flagella synthesis genes and also regulates genes involved in the cell cycle, exopolysaccharide synthesis, and cyclic-di-GMP signaling. CtrA is active as a transcription factor when phosphorylated. It is a member of the OmpR family of DNA-binding response regulators, characterized by a REC domain and a winged helix-turn-helix (wHTH) DNA-binding output effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381132 [Multi-domain]  Cd Length: 114  Bit Score: 43.94  E-value: 4.47e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490278289   4 IIIDDHPLARiAIRNLLDSNGITVAAElDSGAHAVQTAESMQPDLLIVDVDIPELSGIEVLEQLRKRRYQGTIIIISAKN 83
Cdd:cd17616    3 LIEDDSATAQ-SIELMLKSEGFNVYTT-DLGEEGLDLGKLYDYDIILLDLNLPDMSGYEVLRTLRLAKVKTPILILSGLA 80

                         90       100       110
                 ....*....|....*....|....*....|..
gi 490278289  84 ELFYGKRSADCGANGFVSKKEGMNNILAAIDA 115
Cdd:cd17616   81 DIEDKVKGLGFGADDYMTKPFHKDELVARIHA 112
PRK14084 PRK14084
DNA-binding response regulator;
1-81 4.64e-06

DNA-binding response regulator;


Pssm-ID: 184495 [Multi-domain]  Cd Length: 246  Bit Score: 45.90  E-value: 4.64e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490278289   1 MNAIIIDDHPLARIAIRNLLDSNGITvaAELDSGAHAVQTAESM---QPDLLIVDVDIPELSGIEVLEQLRKRRYQGTII 77
Cdd:PRK14084   1 MKALIVDDEPLARNELTYLLNEIGGF--EEINEAENVKETLEALlinQYDIIFLDINLMDESGIELAAKIQKMKEPPAII 78


                 ....
gi 490278289  78 IISA 81
Cdd:PRK14084  79 FATA 82
REC_DctD-like cd17549
phosphoacceptor receiver (REC) domain of C4-dicarboxylic acid transport protein D (DctD) and ...
 4-81 5.48e-06

phosphoacceptor receiver (REC) domain of C4-dicarboxylic acid transport protein D (DctD) and similar proteins; C4-dicarboxylic acid transport protein D (DctD) is part of the two-component regulatory system DctB/DctD, which regulates C4-dicarboxylate transport via regulation of expression of the dctPQM operon and dctA. It is an activator of sigma(54)-RNA polymerase holoenzyme that uses the energy released from ATP hydrolysis to stimulate the isomerization of a closed promoter complex to an open complex capable of initiating transcription. DctD is a member of the NtrC family, characterized by a domain architecture containing an N-terminal REC domain, followed by a central sigma-54 interaction/ATPase domain, and a C-terminal DNA binding domain. The ability of the central domain to hydrolyze ATP and thus to interact effectively with a complex of RNA polymerase, sigma54, and promoter, is controlled by the phosphorylation status of the REC domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381101 [Multi-domain]  Cd Length: 130  Bit Score: 44.02  E-value: 5.48e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 490278289   4 IIIDDHPLARIAIRNLLDSNGITVAAeLDSGAHAVQTAESMQPDLLIVDVDIPELSGIEVLEQLRKRRYQGTIIIISA 81
Cdd:cd17549    2 LLVDDDADVREALQQTLELAGFRVRA-FADAEEALAALSPDFPGVVISDIRMPGMDGLELLAQIRELDPDLPVILITG 78
REC_hyHK_blue-like cd18161
phosphoacceptor receiver (REC) domain of hybrid sensor histidine kinase/response regulators ...
 4-80 5.99e-06

phosphoacceptor receiver (REC) domain of hybrid sensor histidine kinase/response regulators similar to Pseudomonas savastanoi blue-light-activated histidine kinase; Typically, two-component regulatory systems (TCSs) consist of a sensor (histidine kinase) that responds to specific input(s) by modifying the output of a cognate response regulator (RR). TCSs allow organisms to sense and respond to changes in environmental conditions. Hybrid sensor histidine kinase (HK)/response regulators contain all the elements of a classical TCS in a single polypeptide chain. Pseudomonas savastanoi blue-light-activated histidine kinase is a photosensitive HK and RR that is involved in increased bacterial virulence upon exposure to light. RRs share the common phosphoacceptor REC domain and different effector/output domains such as DNA, RNA, ligand-binding, protein-binding, or enzymatic domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381145 [Multi-domain]  Cd Length: 102  Bit Score: 43.49  E-value: 5.99e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 490278289   4 IIIDDHPLARIAIRNLLDSNGITVaAELDSGAHAVQTAES-MQPDLLIVDVDIP-ELSGIEVLEQLRKRRYQGTIIIIS 80
Cdd:cd18161    2 LVVEDDPDVRRLTAEVLEDLGYTV-LEAASGDEALDLLESgPDIDLLVTDVIMPgGMNGSQLAEEARRRRPDLKVLLTS 79
REC_RocR cd17530
phosphoacceptor receiver (REC) domain of response regulator RocR; The response regulator RocR ...
 1-81 8.30e-06

phosphoacceptor receiver (REC) domain of response regulator RocR; The response regulator RocR from some pathogens contains an N-terminal phosphoreceiver (REC) domain and a C-terminal EAL domain that possesses c-di-GMP specific phosphodiesterase activity. The RocR REC domain is phosphorylated and modulates its EAL domain enzymatic activity, regulating the local level of c-di-GMP. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381086 [Multi-domain]  Cd Length: 123  Bit Score: 43.58  E-value: 8.30e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490278289   1 MNAIIIDDHPLARIAIRNLLDSNGITVAAELDSGAHAVQTAESMQPDLLIVDVDIPELSGIEVLEQLRKRRYQGTIIIIS 80
Cdd:cd17530    1 LRVLVLDDDPFQCMMAATILEDLGPGNVDEADDGREALVILLCNAPDIIICDLKMPDMDGIEFLRHLAESHSNAAVILMS 80


                 .
gi 490278289  81 A 81
Cdd:cd17530   81 G 81
dpiA PRK10046
two-component response regulator DpiA; Provisional
 4-102 8.95e-06

two-component response regulator DpiA; Provisional


Pssm-ID: 182208 [Multi-domain]  Cd Length: 225  Bit Score: 45.01  E-value: 8.95e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490278289   4 IIIDDHPLARIA---IRNLLDSNGITVAAELdsgAHAVQTAESMQPDLLIVDVDIPELSGIEVLEQLRKRRYQGTIIIIS 80
Cdd:PRK10046   9 IVEDETPLAEMHaeyIRHIPGFSQILLAGNL---AQARMMIERFKPGLILLDNYLPDGRGINLLHELVQAHYPGDVVFTT 85

                         90       100
                 ....*....|....*....|..
gi 490278289  81 AKNELFYGKRSADCGANGFVSK 102
Cdd:PRK10046  86 AASDMETVSEAVRCGVFDYLIK 107
PRK11083 PRK11083
DNA-binding response regulator CreB; Provisional
 20-84 9.20e-06

DNA-binding response regulator CreB; Provisional


Pssm-ID: 236838 [Multi-domain]  Cd Length: 228  Bit Score: 44.95  E-value: 9.20e-06
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 490278289  20 LDSNGITVAAeLDSGAHAVQTAESMQPDLLIVDVDIPELSGIEVLEQLRKRRYQGTIIIISAKNE 84
Cdd:PRK11083  23 LQSEGFTVEW-FERGLPALDKLRQQPPDLVILDVGLPDISGFELCRQLLAFHPALPVIFLTARSD 86
REC_TPR cd17589
phosphoacceptor receiver (REC) domain of uncharacterized tetratricopeptide repeat (TPR) ...
 3-83 9.96e-06

phosphoacceptor receiver (REC) domain of uncharacterized tetratricopeptide repeat (TPR)-containing response regulators; Response regulators share the common phosphoacceptor REC domain and different output domains. This subfamily contains uncharacterized response regulators with TPR repeats as the effector or output domain, which might contain between 3 to 16 TPR repeats (each about 34 amino acids). TPR-containing proteins occur in all domains of life and the abundance of TPR-containing proteins in a bacterial proteome is not indicative of virulence. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays. Some members in this subfamily may contain inactive REC domains lacking canonical metal-binding and active site residues.


Pssm-ID: 381123 [Multi-domain]  Cd Length: 115  Bit Score: 43.02  E-value: 9.96e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490278289   3 AIIIDDHPLARIAIRNLLDSNGITVAAELDSGAHAVQTAESMQPDLLIVDVDIPE-LSGIEVLEQLRKRRY---QGTIII 78
Cdd:cd17589    1 FLIVDDQPTFRSMLKSMLRSLGVTRIDTASSGEEALRMCENKTYDIVLCDYNLGKgKNGQQLLEELRHKKLispSTVFIM 80


                 ....*
gi 490278289  79 ISAKN 83
Cdd:cd17589   81 VTGES 85
PRK12555 PRK12555
chemotaxis-specific protein-glutamate methyltransferase CheB;
1-81 2.02e-05

chemotaxis-specific protein-glutamate methyltransferase CheB;


Pssm-ID: 237135 [Multi-domain]  Cd Length: 337  Bit Score: 44.10  E-value: 2.02e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490278289   1 MNAIIIDDHPLARIAIRNLLDSN-GITVAAELDSGAHAVQTAESMQPDLLIVDVDIPELSGIEVLEQLRKRRyQGTIIII 79
Cdd:PRK12555   1 MRIGIVNDSPLAVEALRRALARDpDHEVVWVATDGAQAVERCAAQPPDVILMDLEMPRMDGVEATRRIMAER-PCPILIV 79


                 ..
gi 490278289  80 SA 81
Cdd:PRK12555  80 TS 81
REC_OmpR_ChvI-like cd19936
phosphoacceptor receiver (REC) domain of ChvI-like OmpR family response regulators; ...
 5-102 2.02e-05

phosphoacceptor receiver (REC) domain of ChvI-like OmpR family response regulators; Sinorhizobium meliloti ChvI is part of the ExoS/ChvI two-component regulatory system (TCS) that is required for nitrogen-fixing symbiosis and exopolysaccharide synthesis. ExoS/ChvI also play important roles in regulating biofilm formation, motility, nutrient utilization, and the viability of free-living bacteria. ChvI belongs to the OmpR family of DNA-binding response regulators that contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381163 [Multi-domain]  Cd Length: 99  Bit Score: 42.05  E-value: 2.02e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490278289   5 IIDDHPLARIAIRNLLDSNGITVAAELDsGAHAVQTAESMQPDLLIVDVDIPELSGIEVLEQLRKRRyQGTIIIISAKNE 84
Cdd:cd19936    3 LVDDDRNILTSVSMALEAEGFSVETYTD-GASALDGLNARPPDLAILDIKMPRMDGMELLQRLRQKS-TLPVIFLTSKDD 80

                         90
                 ....*....|....*...
gi 490278289  85 LFYGKRSADCGANGFVSK 102
Cdd:cd19936   81 EIDEVFGLRMGADDYITK 98
REC_OmpR_EcPhoP-like cd19934
phosphoacceptor receiver (REC) domain of EcPhoP-like OmpR family response regulators; ...
 4-115 3.72e-05

phosphoacceptor receiver (REC) domain of EcPhoP-like OmpR family response regulators; Escherichia coli PhoP (EcPhoP) is part of the PhoQ/PhoP two-component system (TCS) that regulates virulence genes and plays an essential role in the response of the bacteria to the environment of their mammalian hosts, sensing several stimuli such as extracellular magnesium limitation, low pH, the presence of cationic antimicrobial peptides, and osmotic upshift. This subfamily also includes Brucella suis FeuP, part of the FeuPQ TCS that is involved in the regulation of iron uptake, and Microchaete diplosiphon RcaC, which is required for chromatic adaptation. Members of this subfamily belong to the OmpR family of DNA-binding response regulators, which contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381161 [Multi-domain]  Cd Length: 117  Bit Score: 41.50  E-value: 3.72e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490278289   4 IIIDDHPLARIAIRNLLDSNGITVAAELDsGAHAVQTAESMQPDLLIVDVDIPELSGIEVLEQLRKRRYQGTIIIISAK- 82
Cdd:cd19934    2 LLVEDDALLAAQLKEQLSDAGYVVDVAED-GEEALFQGEEEPYDLVVLDLGLPGMDGLSVLRRWRSEGRATPVLILTARd 80

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 490278289  83 --NELFYGkrsADCGANGFVSKKEGMNNILAAIDA 115
Cdd:cd19934   81 swQDKVEG---LDAGADDYLTKPFHIEELLARLRA 112
REC_OmpR_BaeR-like cd19938
phosphoacceptor receiver (REC) domain of BaeR-like OmpR family response regulators; BaeR is ...
 4-84 4.96e-05

phosphoacceptor receiver (REC) domain of BaeR-like OmpR family response regulators; BaeR is part of the BaeSR two-component system that is involved in regulating genes that confer multidrug and metal resistance. In Salmonella, BaeSR induces AcrD and MdtABC drug efflux systems, increasing multidrug and metal resistance. In Escherichia coli, BaeR stimulates multidrug resistance via mdtABC (multidrug transporter ABC, formerly known as yegMNO) genes, which encode a resistance-nodulation-cell division (RND) drug efflux system. Members of this subfamily belong to the OmpR family of DNA-binding response regulators, which are characterized by a REC domain and a winged helix-turn-helix (wHTH) DNA-binding output effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381165 [Multi-domain]  Cd Length: 114  Bit Score: 41.21  E-value: 4.96e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490278289   4 IIIDDHP-LARIaIRNLLDSNGITVAAeLDSGAHAVQTAESMQPDLLIVDVDIPELSGIEVLEQLRkRRYQGTIIIISAK 82
Cdd:cd19938    3 LIVEDEPkLAQL-LIDYLRAAGYAPTL-LAHGDQVLPYVRHTPPDLILLDLMLPGTDGLTLCREIR-RFSDVPIIMVTAR 79


                 ..
gi 490278289  83 NE 84
Cdd:cd19938   80 VE 81
PRK15479 PRK15479
transcriptional regulator TctD;
1-102 5.65e-05

transcriptional regulator TctD;


Pssm-ID: 185376 [Multi-domain]  Cd Length: 221  Bit Score: 42.40  E-value: 5.65e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490278289   1 MNAIIIDDHPLARIAIRNLLDSNGITVAAELDsGAHAVQTAESMQPDLLIVDVDIPELSGIEVLEQLRKRRYQGTIIIIS 80
Cdd:PRK15479   1 MRLLLAEDNRELAHWLEKALVQNGFAVDCVFD-GLAADHLLQSEMYALAVLDINMPGMDGLEVLQRLRKRGQTLPVLLLT 79

                         90       100
                 ....*....|....*....|..
gi 490278289  81 AKNELFYGKRSADCGANGFVSK 102
Cdd:PRK15479  80 ARSAVADRVKGLNVGADDYLPK 101
PRK10955 PRK10955
envelope stress response regulator transcription factor CpxR;
1-115 6.75e-05

envelope stress response regulator transcription factor CpxR;


Pssm-ID: 182864 [Multi-domain]  Cd Length: 232  Bit Score: 42.10  E-value: 6.75e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490278289   1 MNAIII--DDHPLARIaIRNLLDSNGITVAAELDsGAHAVQTAESmQPDLLIVDVDIPELSGIEVLEQLRKrRYQGTIII 78
Cdd:PRK10955   1 MNKILLvdDDRELTSL-LKELLEMEGFNVIVAHD-GEQALDLLDD-SIDLLLLDVMMPKKNGIDTLKELRQ-THQTPVIM 76

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 490278289  79 ISAKNELFYGKRSADCGANGFVSKKEGMNNILAAIDA 115
Cdd:PRK10955  77 LTARGSELDRVLGLELGADDYLPKPFNDRELVARIRA 113
REC_OmpR_VirG cd17594
phosphoacceptor receiver (REC) domain of VirG-like OmpR family response regulators; VirG is ...
 4-115 7.63e-05

phosphoacceptor receiver (REC) domain of VirG-like OmpR family response regulators; VirG is part of the VirA/VirG two-component system that regulates the expression of virulence (vir) genes. The histidine kinase VirA senses a phenolic wound response signal, undergoes autophosphorylation, and phosphorelays to the VirG response regulator, which induces transcription of the vir regulon. VirG belongs to the OmpR family of DNA-binding response regulators that contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381125 [Multi-domain]  Cd Length: 113  Bit Score: 40.51  E-value: 7.63e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490278289   4 IIIDDHPLARIAIRNLLDSNGITVAAELDsGAHAVQTAESMQPDLLIVDVDIPELSGIEVLEQLRkRRYQGTIIIISAKN 83
Cdd:cd17594    3 LVVDDDAAMRHLLILYLRERGFDVTAAAD-GAEEARLMLHRRVDLVLLDLRLGQESGLDLLRTIR-ARSDVPIIIISGDR 80

                         90       100       110
                 ....*....|....*....|....*....|...
gi 490278289  84 ELFYGKRSA-DCGANGFVSKKEGMNNILAAIDA 115
Cdd:cd17594   81 RDEIDRVVGlELGADDYLAKPFGLRELLARVRA 113
REC_hyHK cd17598
phosphoacceptor receiver (REC) domain of uncharacterized hybrid sensor histidine kinase ...
 4-102 1.03e-04

phosphoacceptor receiver (REC) domain of uncharacterized hybrid sensor histidine kinase/response regulators; Typically, two-component regulatory systems (TCSs) consist of a sensor (histidine kinase) that responds to specific input(s) by modifying the output of a cognate response regulator (RR). TCSs allow organisms to sense and respond to changes in environmental conditions. Hybrid sensor histidine kinase/response regulators contain all the elements of a classical TCS in a single polypeptide chain. RRs share the common phosphoacceptor REC domain and different effector/output domains such as DNA, RNA, ligand-binding, protein-binding, or enzymatic domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381128 [Multi-domain]  Cd Length: 118  Bit Score: 40.39  E-value: 1.03e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490278289   4 IIIDDHPLARIAIRNLLDSNGITVAAELDsGAHAVQTAESMQPDLLIVDVDIPELSGIEVLEQLRKRRYQGTI--IIISA 81
Cdd:cd17598    2 LIVEDSPTQAEQLKHILEEQGYKVQVARN-GREALAMLAEHRPTLVISDIVMPEMDGYELCRKIKSDPDLKDIpvILLTT 80

                         90       100
                 ....*....|....*....|.
gi 490278289  82 KNELFYGKRSADCGANGFVSK 102
Cdd:cd17598   81 LSDPRDVIRGLECGADNFITK 101
REC_PhyR cd17540
phosphoacceptor receiver (REC) domain of response regulator PhyR and similar proteins; PhyR is ...
 3-81 1.72e-04

phosphoacceptor receiver (REC) domain of response regulator PhyR and similar proteins; PhyR is a hybrid stress regulator that contains an N-terminal sigma-like (SL) domain and a C-terminal REC domain. Phosphorylation of the REC domain is known to promote binding of the SL domain to an anti-sigma factor. PhyR thus functions as an anti-anti-sigma factor in its phosphorylated state. It is involved in the general stress response. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381095 [Multi-domain]  Cd Length: 117  Bit Score: 39.54  E-value: 1.72e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490278289   3 AIIIDDHPLARIAIRNLLDSNGITVAAELDSGAHAVQTAESMQPDLLIVDVDIPE-LSGIEVLEQLRKRRyQGTIIIISA 81
Cdd:cd17540    3 VLIIEDEPLIAMDLEQIVEDLGHQVVGIARTRDEAVALARRERPDLILADIQLADgSSGIDAVNEILTTH-DVPVIFVTA 81
REC_Rcp-like cd17557
phosphoacceptor receiver (REC) domain of cyanobacterial phytochrome response regulator Rcp and ...
 5-115 2.34e-04

phosphoacceptor receiver (REC) domain of cyanobacterial phytochrome response regulator Rcp and similar domains; This family is composed of response regulators (RRs) that are members of phytochrome-associated, light-sensing two-component signal transduction pathways such as Synechocystis sp. Rcp1, Tolypothrix sp. RcpA, and Agrobacterium tumefaciens bacteriophytochrome response regulator AtBRR. They are stand-alone RRs containing only a REC domain with no output/effector domain. The REC domain itself functions as an effector domain. Also included in this family us Methanosaeta harundinacea methanogenesis regulatory protein FilR2, also a stand-alone RR. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381108 [Multi-domain]  Cd Length: 129  Bit Score: 39.32  E-value: 2.34e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490278289   5 IIDDHP----LARIAIRNLLDSNGITVAAeldSGAHAV-------QTAESMQPDLLIVDVDIPELSGIEVLEQLRKRRYQ 73
Cdd:cd17557    4 LVEDNPgdaeLIQEAFKEAGVPNELHVVR---DGEEALdflrgegEYADAPRPDLILLDLNMPRMDGFEVLREIKADPDL 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 490278289  74 GTIIII-----SAKNELFygkRSADCGANGFVSKKEGMNNILAAIDA 115
Cdd:cd17557   81 RRIPVVvlttsDAEEDIE---RAYELGANSYIVKPVDFEEFVEAIRS 124
glnG PRK10923
nitrogen regulation protein NR(I); Provisional
 5-85 2.48e-04

nitrogen regulation protein NR(I); Provisional


Pssm-ID: 182842 [Multi-domain]  Cd Length: 469  Bit Score: 41.01  E-value: 2.48e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490278289   5 IIDDHPLARIAIRNLLDSNGITVAAEldSGAHAVQTAESMQ-PDLLIVDVDIPELSGIEVLEQLRKRRYQGTIIIISAKN 83
Cdd:PRK10923   8 VVDDDSSIRWVLERALAGAGLTCTTF--ENGNEVLEALASKtPDVLLSDIRMPGMDGLALLKQIKQRHPMLPVIIMTAHS 85


                 ..
gi 490278289  84 EL 85
Cdd:PRK10923  86 DL 87
orf27 CHL00148
Ycf27; Reviewed
 4-102 4.36e-04

Ycf27; Reviewed


Pssm-ID: 214376 [Multi-domain]  Cd Length: 240  Bit Score: 40.08  E-value: 4.36e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490278289   4 IIIDDHPLARIAIRNLLDSNGITVAAELDsGAHAVQTAESMQPDLLIVDVDIPELSGIEVLEQLRKRRyQGTIIIISAKN 83
Cdd:CHL00148  10 LVVDDEAYIRKILETRLSIIGYEVITASD-GEEALKLFRKEQPDLVILDVMMPKLDGYGVCQEIRKES-DVPIIMLTALG 87

                         90
                 ....*....|....*....
gi 490278289  84 ELFYGKRSADCGANGFVSK 102
Cdd:CHL00148  88 DVSDRITGLELGADDYVVK 106
REC_OmpR_RegX3-like cd17621
phosphoacceptor receiver (REC) domain of RegX3-like OmpR family response regulators; RegX3 is ...
 4-102 4.59e-04

phosphoacceptor receiver (REC) domain of RegX3-like OmpR family response regulators; RegX3 is a member of the SenX3-RegX3 two-component system that is involved in phosphate-sensing signal transduction. Phosphorylated RegX3 functions as a transcriptional activator of phoA. It induces transcription in phosphate limiting environment and also controls expression of several critical metabolic enzymes in aerobic condition. RegX3 belongs to the OmpR family of DNA-binding response regulators that contain N-terminal receiver and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381136 [Multi-domain]  Cd Length: 99  Bit Score: 38.33  E-value: 4.59e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490278289   4 IIIDDHPLARIAIRNLLDSNGITVAAeLDSGAHAVQTAESMQPDLLIVDVDIPELSGIEVLEQLRKRRyQGTIIIISAKN 83
Cdd:cd17621    2 LVVEDEESFSDPLAYLLRKEGFEVTV-ATDGPAALAEFDRAGADIVLLDLMLPGLSGTEVCRQLRARS-NVPVIMVTAKD 79

                         90
                 ....*....|....*....
gi 490278289  84 ELFYGKRSADCGANGFVSK 102
Cdd:cd17621   80 SEIDKVVGLELGADDYVTK 98
REC_PFxFATGY cd17586
phosphoacceptor receiver (REC) domain of PFxFATGY motif single-domain (stand-alone) response ...
 4-70 5.00e-04

phosphoacceptor receiver (REC) domain of PFxFATGY motif single-domain (stand-alone) response regulators; This subfamily is composed of stand-alone response regulators (RRs) containing the PFxFATG[G/Y] motif; RRs with such a motif are also called ''FAT GUY'' response regulators. Included in this subfamily are Sphingomonas melonis SdrG, Sinorhizobium meliloti Sma0114, and Erythrobacter litoralis EL_LovR. SdrG is involved in the control of the general stress response. Sma0114 is part of the Sma0113/Sma0114 two-component system (TCS) that is involved in catabolite repression and polyhydroxy butyrate synthesis. EL_LovR is involved in a light-regulated TCS. PFxFATG[G/Y] RRs are typically associated with histidine-tryptophan-glutamate (HWE) histidine kinases that constitute a subclass of the larger histidine kinase superfamily characterized by an altered ATP binding site, which lacks the F-box that is normally an integral component of the ATP lid. The PFxFATG[G/Y] motif is involved in conformational changes after phosphorylation that results in the activation of the RR. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381122 [Multi-domain]  Cd Length: 111  Bit Score: 38.22  E-value: 5.00e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 490278289   4 IIIDDHPLARIAIRNLLDSNGITVAAELDSGAHAVQTAESMQPDLLIVDVDIPELSGIEVLEQLRKR 70
Cdd:cd17586    2 LVLEDEPLIAMNLEDALEDLGGKEVVTAATCAEALRSLADGPIDIAILDVNLGGETSIPVADALKRR 68
GerE COG5905
Spore transcriptional regulator GerE (stand-alone HTH domain) [Cell cycle control, cell ...
 139-200 7.46e-04

Spore transcriptional regulator GerE (stand-alone HTH domain) [Cell cycle control, cell division, chromosome partitioning, Transcription];


Pssm-ID: 444607 [Multi-domain]  Cd Length: 76  Bit Score: 36.86  E-value: 7.46e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 490278289 139 DRLDTLSTQEMKVFRYILSGVDYTTIGSKMNISNKTVSTYKVRLMDKLGCSTLLELYDFAQR 200
Cdd:COG5905    8 SHPSLLTKREREVLELLAEGLTNKEIARQLFISEKTVKNHVSNILRKLGVRNRVQAVVWALR 69
PRK15115 PRK15115
response regulator GlrR; Provisional
 2-116 1.37e-03

response regulator GlrR; Provisional


Pssm-ID: 185070 [Multi-domain]  Cd Length: 444  Bit Score: 38.66  E-value: 1.37e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490278289   2 NAIIIDDHP--LARIAIRnlLDSNGITVAAElDSGAHAVQTAESMQPDLLIVDVDIPELSGIEVLEQLRKRRYQGTIIII 79
Cdd:PRK15115   7 HLLLVDDDPglLKLLGMR--LTSEGYSVVTA-ESGQEALRVLNREKVDLVISDLRMDEMDGMQLFAEIQKVQPGMPVIIL 83

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 490278289  80 SAKNELFYGKRSADCGANGFVSKKEGMNNILAAIDAA 116
Cdd:PRK15115  84 TAHGSIPDAVAATQQGVFSFLTKPVDRDALYKAIDDA 120
REC_OmpR_NsrR-like cd18159
phosphoacceptor receiver (REC) domain of Streptococcus agalactiae NsrR-like OmpR family ...
 3-116 1.86e-03

phosphoacceptor receiver (REC) domain of Streptococcus agalactiae NsrR-like OmpR family response regulators; Streptococcus agalactiae NsrR is a lantibiotic resistance-associated response regulator and is part of the nisin resistance operon. It is a member of the NsrRK two-component system (TCS) that is involved in the regulation of lantibiotic resistance genes such as a membrane-associated lipoprotein of LanI, and the nsr gene cluster which encodes for the resistance protein NSR and the ABC transporter NsrFP, both conferring resistance against nisin. This subfamily also includes Staphylococcus epidermidis GraR, part of the GraR/GraS TCS involved in resistance against cationic antimicrobial peptides, and Bacillus subtilis BceR, part of the BceS/BceR TCS involved in the regulation of bacitracin resistance. Members of this subfamily belong to the OmpR family of DNA-binding response regulators, which contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381143 [Multi-domain]  Cd Length: 113  Bit Score: 36.88  E-value: 1.86e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490278289   3 AIIIDDHPLARIaIRNLLDSNGITVAAeLDSGAHAVQTAESMQPDLLIVDVDIPELSGIEVLEQLRKRRyQGTIIIISAK 82
Cdd:cd18159    2 LIVEDDETIASL-LKKHLEKWGYEVVL-IEDFEDVLEEFLQFKPDLVLLDINLPYFDGFYWCREIRQIS-NVPIIFISSR 78

                         90       100       110
                 ....*....|....*....|....*....|....
gi 490278289  83 NELFYGKRSADCGANGFVSKKEGMNNILAAIDAA 116
Cdd:cd18159   79 DDNMDQVMAINMGGDDYITKPFDLDVLLAKIKAI 112
REC_OmpR_MtrA-like cd17626
phosphoacceptor receiver (REC) domain of MtrA-like OmpR family response regulators; MtrA is ...
 4-102 2.80e-03

phosphoacceptor receiver (REC) domain of MtrA-like OmpR family response regulators; MtrA is part of MtrA/MtrB (or MtrAB), a highly conserved two-component system (TCS) implicated in the regulation of cell division in the actinobacteria. In unicellular Mycobacterium tuberculosis, MtrAB coordinates DNA replication with cell division and regulates the transcription of resuscitation-promoting factor B. In filamentous Streptomyces venezuelae, it links antibiotic production to sporulation. MtrA belongs to the OmpR family of DNA-binding response regulators that contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381141 [Multi-domain]  Cd Length: 115  Bit Score: 36.29  E-value: 2.80e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490278289   4 IIIDDHPLARIaIRNLLDSNGITVAAELDsGAHAVQTAESMQPDLLIVDVDIPELSGIEVLEQLRKRryQGT-IIIISAK 82
Cdd:cd17626    5 VVDDDAALAEM-IGIVLRGEGFDPAFCGD-GTQALAAFREVRPDLVLLDLMLPGIDGIEVCRQIRAE--SGVpIVMLTAK 80

                         90       100
                 ....*....|....*....|
gi 490278289  83 NELFYGKRSADCGANGFVSK 102
Cdd:cd17626   81 SDTVDVVLGLESGADDYVAK 100
PRK10161 PRK10161
phosphate response regulator transcription factor PhoB;
4-115 3.47e-03

phosphate response regulator transcription factor PhoB;


Pssm-ID: 182277 [Multi-domain]  Cd Length: 229  Bit Score: 37.39  E-value: 3.47e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490278289   4 IIIDDHPLARIAIRNLLDSNGITvAAELDSGAHAVQTAESMQPDLLIVDVDIPELSGIEVLEQLRKRRYQGTI--IIISA 81
Cdd:PRK10161   6 LVVEDEAPIREMVCFVLEQNGFQ-PVEAEDYDSAVNQLNEPWPDLILLDWMLPGGSGIQFIKHLKRESMTRDIpvVMLTA 84

                         90       100       110
                 ....*....|....*....|....*....|....
gi 490278289  82 KNELFYGKRSADCGANGFVSKKEGMNNILAAIDA 115
Cdd:PRK10161  85 RGEEEDRVRGLETGADDYITKPFSPKELVARIKA 118
REC_HupR cd17596
phosphoacceptor receiver (REC) domain of hydrogen uptake protein regulator (HupR); Members of ...
 4-81 4.15e-03

phosphoacceptor receiver (REC) domain of hydrogen uptake protein regulator (HupR); Members of this subfamily are response regulator components of two-component systems that regulates hydrogenase activity, including HupR and HoxA. HupR is part of the HupT/HupR system that controls the synthesis of the membrane-bound [NiFe]hydrogenase, HupSL, of the photosynthetic bacterium Rhodobacter capsulatus. It belongs to the nitrogen regulatory protein C (NtrC) family of response regulators, which activate transcription by RNA polymerase (RNAP) in response to a change in the environment. HupR is an unusual member of this family as it activates transcription when unphosphorylated, and transcription is inhibited by phosphorylation. Proteins in this subfamily contain an N-terminal REC domain, a central sigma-54 interaction domain that lacks ATPase activity, and a C-terminal DNA-binding domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381127 [Multi-domain]  Cd Length: 133  Bit Score: 36.19  E-value: 4.15e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 490278289   4 IIIDDHPLARIAIRNLLDSNGITVAAELDSGAHAVQTAESMQpdLLIVDVDIPELSGIEVLEQLRkRRYQGTI-IIISA 81
Cdd:cd17596    4 LVVDDEVRSLEALRRTLEEDFDVLTAASAEEALAILEEEWVQ--VILCDQRMPGTTGVEFLKEVR-ERWPEVVrIIISG 79
PRK10816 PRK10816
two-component system response regulator PhoP;
1-186 6.59e-03

two-component system response regulator PhoP;


Pssm-ID: 182755 [Multi-domain]  Cd Length: 223  Bit Score: 36.26  E-value: 6.59e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490278289   1 MNAIIIDDHPLARIAIRNLLDSNGITVAAELDSGAHAVQTAESMqPDLLIVDVDIPELSGIEVLEQLRKRRYQGTIIIIS 80
Cdd:PRK10816   1 MRVLVVEDNALLRHHLKVQLQDAGHQVDAAEDAKEADYYLNEHL-PDIAIVDLGLPDEDGLSLIRRWRSNDVSLPILVLT 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490278289  81 AKnELFYGKRSA-DCGANGFVSKKEGMNNILAAIDA---ANNGYSYFPFSLERFcthgitdqdRLDtLSTQEMKVFRYI- 155
Cdd:PRK10816  80 AR-ESWQDKVEVlSAGADDYVTKPFHIEEVMARMQAlmrRNSGLASQVISLPPF---------QVD-LSRRELSINDEVi 148

                        170       180       190
                 ....*....|....*....|....*....|..
gi 490278289 156 -LSGVDYTTIGSKMNISNKTVStyKVRLMDKL 186
Cdd:PRK10816 149 kLTAFEYTIMETLIRNNGKVVS--KDSLMLQL 178
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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