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Conserved domains on  [gi|490261912|ref|WP_004159130|]
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GntR family transcriptional regulator [Erwinia amylovora]

Protein Classification

GntR family transcriptional regulator( domain architecture ID 11448455)

GntR-family transcriptional regulator is one of a group of transcriptional regulators with a conserved N-terminal helix-turn-helix DNA-binding domain and a diverse C-terminal effector-binding and oligomerization domain; controls the expression of genes with diverse biological functions

CATH:  1.10.10.10
Gene Ontology:  GO:0003700|GO:0003677
PubMed:  33509775
SCOP:  4000155

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
GntR COG1802
DNA-binding transcriptional regulator, GntR family [Transcription];
6-218 9.04e-57

DNA-binding transcriptional regulator, GntR family [Transcription];


:

Pssm-ID: 441407 [Multi-domain]  Cd Length: 222  Bit Score: 179.73  E-value: 9.04e-57
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490261912   6 TPDLSNVPSTSDVITQYLRRAILNGHFAENEPVRQDEIAKKFNVSKIPVREALKKLEAEGLVVFVKNKGATVTRMSDDEL 85
Cdd:COG1802    3 SPSPLRRESLAEQVYEALREAILSGELPPGERLSEAELAERLGVSRTPVREALRRLEAEGLVEIRPNRGARVAPLSPEEI 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490261912  86 AQLFEMRILLEVRLLELAIPNMQMADFLHIEEV---GNKYISDPNIMNWSALNWDFHLALYRAANRPLIVDSVKMINQKL 162
Cdd:COG1802   83 RELYEVRAALEGLAARLAAERATPADLARLRALleeLEAAAAAGDVAAYLELDREFHRALVEAAGNPRLAELLRRLRARL 162

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 490261912 163 ERYLRMQLSLSNGKEKSDREHAEIISLCRQKNIPGAVDLLKKHIYGVCQSLLDNLH 218
Cdd:COG1802  163 RRYRRLSLRSPGRLEESLAEHRAILDALEAGDAEAAAAALRAHLERARERLLEALA 218
 
Name Accession Description Interval E-value
GntR COG1802
DNA-binding transcriptional regulator, GntR family [Transcription];
6-218 9.04e-57

DNA-binding transcriptional regulator, GntR family [Transcription];


Pssm-ID: 441407 [Multi-domain]  Cd Length: 222  Bit Score: 179.73  E-value: 9.04e-57
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490261912   6 TPDLSNVPSTSDVITQYLRRAILNGHFAENEPVRQDEIAKKFNVSKIPVREALKKLEAEGLVVFVKNKGATVTRMSDDEL 85
Cdd:COG1802    3 SPSPLRRESLAEQVYEALREAILSGELPPGERLSEAELAERLGVSRTPVREALRRLEAEGLVEIRPNRGARVAPLSPEEI 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490261912  86 AQLFEMRILLEVRLLELAIPNMQMADFLHIEEV---GNKYISDPNIMNWSALNWDFHLALYRAANRPLIVDSVKMINQKL 162
Cdd:COG1802   83 RELYEVRAALEGLAARLAAERATPADLARLRALleeLEAAAAAGDVAAYLELDREFHRALVEAAGNPRLAELLRRLRARL 162

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 490261912 163 ERYLRMQLSLSNGKEKSDREHAEIISLCRQKNIPGAVDLLKKHIYGVCQSLLDNLH 218
Cdd:COG1802  163 RRYRRLSLRSPGRLEESLAEHRAILDALEAGDAEAAAAALRAHLERARERLLEALA 218
FCD smart00895
This entry represents the C-terminal ligand binding domain of many members of the GntR family; ...
 87-206 4.64e-18

This entry represents the C-terminal ligand binding domain of many members of the GntR family; This domain probably binds to a range of effector molecules that regulate the transcription of genes through the action of the N-terminal DNA-binding domain. This domain is found in and that are regulators of sugar biosynthesis operons. Many bacterial transcription regulation proteins bind DNA through a helix-turn-helix (HTH) motif, which can be classified into subfamilies on the basis of sequence similarities. The HTH GntR family has many members distributed among diverse bacterial groups that regulate various biological processes. It was named GntR after the Bacillus subtilis repressor of the gluconate operon. In general, these proteins contain a DNA-binding HTH domain at the N terminus, and an effector binding or oligomerisation domain at the C terminus. The winged-helix DNA-binding domain is well conserved in structure for the whole of the GntR family, and is similar in structure to other transcriptional regulator families. The C-terminal effector-binding and oligomerisation domains are more variable and are consequently used to define the subfamilies. Based on the sequence and structure of the C-terminal domains, the GtnR family can be divided into four major groups, as represented by FadR, HutC, MocR and YtrA, as well as some minor groups such as those represented by AraR and PlmA.


Pssm-ID: 214892 [Multi-domain]  Cd Length: 123  Bit Score: 77.01  E-value: 4.64e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490261912    87 QLFEMRILLEVRLLELAIPNMQMADFLHIEEVGNKYI----SDPNIMNWSALNWDFHLALYRAANRPLIVDSVKMINQKL 162
Cdd:smart00895   1 ELYEVRRALEPLAARLAAERATDEDLAALEALLDAMEaaaaAGDDLEEFAELDREFHRALAEAAGNPVLLELLESLRARL 80

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....
gi 490261912   163 ERYLRMQLSLSNGkekSDREHAEIISLCRQKNIPGAVDLLKKHI 206
Cdd:smart00895  81 RRLRRLSLEAARR---ALDEHRAILDAIRARDAEAARAAMREHL 121
FCD pfam07729
FCD domain; This domain is the C-terminal ligand binding domain of many members of the GntR ...
 87-203 6.81e-17

FCD domain; This domain is the C-terminal ligand binding domain of many members of the GntR family. This domain binds to a range of effector molecules, including Lactate, Zn(II), Ni(II), Ca(II), Mg(II), citrate, sugar acids, sialic acid and N-acetylglucosamine-6-P, that regulate the transcription of genes through the action of the N-terminal DNA-binding domain pfam00392 (Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043). This domain is found in Swiss:P45427 and Swiss:P31460 that are regulators of sugar biosynthesis operons. It is also in the known structure of FadR where it binds to acyl-coA, the domain is alpha helical. This family has been named as FCD for (FadR C-terminal Domain).


Pssm-ID: 429623 [Multi-domain]  Cd Length: 121  Bit Score: 73.94  E-value: 6.81e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490261912   87 QLFEMRILLEVRLLELAIPNM---QMADFLHIEEVGNKYISDPNIMNWSALNWDFHLALYRAANRPLIVDSVKMINQKLE 163
Cdd:pfam07729   1 ELYELRAALEPLAARLAAERAtdeDLAELEALLEALEAAADAGDLEAFAEADREFHLALAEAAGNPVLARMLESLWDRLR 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 490261912  164 RYLRMQLSLSNGKEKSDREHAEIISLCRQKNIPGAVDLLK 203
Cdd:pfam07729  81 RLRRLLLSSPGRLRASLEEHRAILDAIRARDPEAARAAMR 120
WHTH_GntR cd07377
Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional ...
 14-78 1.98e-14

Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; This CD represents the winged HTH DNA-binding domain of the GntR (named after the gluconate operon repressor in Bacillus subtilis) family of bacterial transcriptional regulators and their putative homologs found in eukaryota and archaea. The GntR family has over 6000 members distributed among almost all bacterial species, which is comprised of FadR, HutC, MocR, YtrA, AraR, PlmA, and other subfamilies for the regulation of the most varied biological process. The monomeric proteins of the GntR family are characterized by two function domains: a small highly conserved winged helix-turn-helix prokaryotic DNA binding domain in the N-terminus, and a very diverse regulatory ligand-binding domain in the C-terminus for effector-binding/oligomerization, which provides the basis for the subfamily classifications. Binding of the effector to GntR-like transcriptional regulators is presumed to result in a conformational change that regulates the DNA-binding affinity of the repressor. The GntR-like proteins bind as dimers, where each monomer recognizes a half-site of 2-fold symmetric DNA sequences.


Pssm-ID: 153418 [Multi-domain]  Cd Length: 66  Bit Score: 65.55  E-value: 1.98e-14
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 490261912  14 STSDVITQYLRRAILNGHFAENEPVR-QDEIAKKFNVSKIPVREALKKLEAEGLVVFVKNKGATVT 78
Cdd:cd07377    1 PLYEQIADQLREAILSGELKPGDRLPsERELAEELGVSRTTVREALRELEAEGLVERRPGRGTFVA 66
PRK11534 PRK11534
DNA-binding transcriptional regulator CsiR; Provisional
 13-206 1.44e-12

DNA-binding transcriptional regulator CsiR; Provisional


Pssm-ID: 183181 [Multi-domain]  Cd Length: 224  Bit Score: 64.53  E-value: 1.44e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490261912  13 PSTSDVITQY--LRRAILNGHFAENEPVRQDEIAKKFNVSKIPVREALKKLEAEGLVVFVKNKGATVTRMSDDELAQLFE 90
Cdd:PRK11534   4 PMQITALDGYrwLKNDIIRGNFQPDEKLRMSLLTSRYALGVGPLREALSQLVAERLVTVVNQKGYRVASMSEQELLDIFD 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490261912  91 MRILLEVRLLELAIP---NMQMADFLHIEEVGNKYI----SDPNIMNWSALNWDFHLALYRAANRPLIVDSVKMINQKLE 163
Cdd:PRK11534  84 ARANMEAMLVSLAIArggDEWEADVLAKAHLLSKLEacdaSEKMLDEWDLRHQAFHTAIVAGCGSHYLLQMRERLFDLAA 163

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*..
gi 490261912 164 RY----LRMQLSLSNGKEKSDREHAEIISLCRQKNIPGAVDLLKKHI 206
Cdd:PRK11534 164 RYrfiwLRRTVLSVEMLEDKHDQHQTLTAAILARDTARASELMRQHL 210
 
Name Accession Description Interval E-value
GntR COG1802
DNA-binding transcriptional regulator, GntR family [Transcription];
6-218 9.04e-57

DNA-binding transcriptional regulator, GntR family [Transcription];


Pssm-ID: 441407 [Multi-domain]  Cd Length: 222  Bit Score: 179.73  E-value: 9.04e-57
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490261912   6 TPDLSNVPSTSDVITQYLRRAILNGHFAENEPVRQDEIAKKFNVSKIPVREALKKLEAEGLVVFVKNKGATVTRMSDDEL 85
Cdd:COG1802    3 SPSPLRRESLAEQVYEALREAILSGELPPGERLSEAELAERLGVSRTPVREALRRLEAEGLVEIRPNRGARVAPLSPEEI 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490261912  86 AQLFEMRILLEVRLLELAIPNMQMADFLHIEEV---GNKYISDPNIMNWSALNWDFHLALYRAANRPLIVDSVKMINQKL 162
Cdd:COG1802   83 RELYEVRAALEGLAARLAAERATPADLARLRALleeLEAAAAAGDVAAYLELDREFHRALVEAAGNPRLAELLRRLRARL 162

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 490261912 163 ERYLRMQLSLSNGKEKSDREHAEIISLCRQKNIPGAVDLLKKHIYGVCQSLLDNLH 218
Cdd:COG1802  163 RRYRRLSLRSPGRLEESLAEHRAILDALEAGDAEAAAAALRAHLERARERLLEALA 218
FadR COG2186
DNA-binding transcriptional regulator, FadR family [Transcription];
13-217 1.57e-31

DNA-binding transcriptional regulator, FadR family [Transcription];


Pssm-ID: 441789 [Multi-domain]  Cd Length: 232  Bit Score: 115.03  E-value: 1.57e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490261912  13 PSTSDVITQYLRRAILNGHFAENE---PVRqdEIAKKFNVSKIPVREALKKLEAEGLVVFVKNKGATVT----------- 78
Cdd:COG2186    6 RSLAEQVAEQLRELILSGELKPGDrlpSER--ELAEQLGVSRTTVREALRALEALGLVEVRQGGGTFVRepspwalldpl 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490261912  79 ----RMSDDELAQLFEMRILLEVRLLELAIPNMQMADFLHIEEVGNKYI-SDPNIMNWSALNWDFHLALYRAANRPLIVD 153
Cdd:COG2186   84 alllALDDASLRDLLEARLALEPEAARLAAERATDEDLARLEAALAEMEaAADDGEAFAEADLAFHRAIAEASGNPLLAL 163

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 490261912 154 SVKMINQKLERYLRMQLSLSNGKEKSDREHAEIISLCRQKNIPGAVDLLKKHIYGVCQSLLDNL 217
Cdd:COG2186  164 LLESLRELLRRSVRLTLRSPEARERSLAEHRAILDAIRAGDPEAARAAMRAHLEAVRERLREAL 227
FCD smart00895
This entry represents the C-terminal ligand binding domain of many members of the GntR family; ...
 87-206 4.64e-18

This entry represents the C-terminal ligand binding domain of many members of the GntR family; This domain probably binds to a range of effector molecules that regulate the transcription of genes through the action of the N-terminal DNA-binding domain. This domain is found in and that are regulators of sugar biosynthesis operons. Many bacterial transcription regulation proteins bind DNA through a helix-turn-helix (HTH) motif, which can be classified into subfamilies on the basis of sequence similarities. The HTH GntR family has many members distributed among diverse bacterial groups that regulate various biological processes. It was named GntR after the Bacillus subtilis repressor of the gluconate operon. In general, these proteins contain a DNA-binding HTH domain at the N terminus, and an effector binding or oligomerisation domain at the C terminus. The winged-helix DNA-binding domain is well conserved in structure for the whole of the GntR family, and is similar in structure to other transcriptional regulator families. The C-terminal effector-binding and oligomerisation domains are more variable and are consequently used to define the subfamilies. Based on the sequence and structure of the C-terminal domains, the GtnR family can be divided into four major groups, as represented by FadR, HutC, MocR and YtrA, as well as some minor groups such as those represented by AraR and PlmA.


Pssm-ID: 214892 [Multi-domain]  Cd Length: 123  Bit Score: 77.01  E-value: 4.64e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490261912    87 QLFEMRILLEVRLLELAIPNMQMADFLHIEEVGNKYI----SDPNIMNWSALNWDFHLALYRAANRPLIVDSVKMINQKL 162
Cdd:smart00895   1 ELYEVRRALEPLAARLAAERATDEDLAALEALLDAMEaaaaAGDDLEEFAELDREFHRALAEAAGNPVLLELLESLRARL 80

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....
gi 490261912   163 ERYLRMQLSLSNGkekSDREHAEIISLCRQKNIPGAVDLLKKHI 206
Cdd:smart00895  81 RRLRRLSLEAARR---ALDEHRAILDAIRARDAEAARAAMREHL 121
FCD pfam07729
FCD domain; This domain is the C-terminal ligand binding domain of many members of the GntR ...
 87-203 6.81e-17

FCD domain; This domain is the C-terminal ligand binding domain of many members of the GntR family. This domain binds to a range of effector molecules, including Lactate, Zn(II), Ni(II), Ca(II), Mg(II), citrate, sugar acids, sialic acid and N-acetylglucosamine-6-P, that regulate the transcription of genes through the action of the N-terminal DNA-binding domain pfam00392 (Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043). This domain is found in Swiss:P45427 and Swiss:P31460 that are regulators of sugar biosynthesis operons. It is also in the known structure of FadR where it binds to acyl-coA, the domain is alpha helical. This family has been named as FCD for (FadR C-terminal Domain).


Pssm-ID: 429623 [Multi-domain]  Cd Length: 121  Bit Score: 73.94  E-value: 6.81e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490261912   87 QLFEMRILLEVRLLELAIPNM---QMADFLHIEEVGNKYISDPNIMNWSALNWDFHLALYRAANRPLIVDSVKMINQKLE 163
Cdd:pfam07729   1 ELYELRAALEPLAARLAAERAtdeDLAELEALLEALEAAADAGDLEAFAEADREFHLALAEAAGNPVLARMLESLWDRLR 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 490261912  164 RYLRMQLSLSNGKEKSDREHAEIISLCRQKNIPGAVDLLK 203
Cdd:pfam07729  81 RLRRLLLSSPGRLRASLEEHRAILDAIRARDPEAARAAMR 120
WHTH_GntR cd07377
Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional ...
 14-78 1.98e-14

Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; This CD represents the winged HTH DNA-binding domain of the GntR (named after the gluconate operon repressor in Bacillus subtilis) family of bacterial transcriptional regulators and their putative homologs found in eukaryota and archaea. The GntR family has over 6000 members distributed among almost all bacterial species, which is comprised of FadR, HutC, MocR, YtrA, AraR, PlmA, and other subfamilies for the regulation of the most varied biological process. The monomeric proteins of the GntR family are characterized by two function domains: a small highly conserved winged helix-turn-helix prokaryotic DNA binding domain in the N-terminus, and a very diverse regulatory ligand-binding domain in the C-terminus for effector-binding/oligomerization, which provides the basis for the subfamily classifications. Binding of the effector to GntR-like transcriptional regulators is presumed to result in a conformational change that regulates the DNA-binding affinity of the repressor. The GntR-like proteins bind as dimers, where each monomer recognizes a half-site of 2-fold symmetric DNA sequences.


Pssm-ID: 153418 [Multi-domain]  Cd Length: 66  Bit Score: 65.55  E-value: 1.98e-14
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 490261912  14 STSDVITQYLRRAILNGHFAENEPVR-QDEIAKKFNVSKIPVREALKKLEAEGLVVFVKNKGATVT 78
Cdd:cd07377    1 PLYEQIADQLREAILSGELKPGDRLPsERELAEELGVSRTTVREALRELEAEGLVERRPGRGTFVA 66
GntR pfam00392
Bacterial regulatory proteins, gntR family; This family of regulatory proteins consists of the ...
 15-77 8.02e-13

Bacterial regulatory proteins, gntR family; This family of regulatory proteins consists of the N-terminal HTH region of GntR-like bacterial transcription factors. At the C-terminus there is usually an effector-binding/oligomerization domain. The GntR-like proteins include the following sub-families: MocR, YtrR, FadR, AraR, HutC and PlmA, DevA, DasR. Many of these proteins have been shown experimentally to be autoregulatory, enabling the prediction of operator sites and the discovery of cis/trans relationships. The DasR regulator has been shown to be a global regulator of primary metabolism and development in Streptomyces coelicolor.


Pssm-ID: 306822 [Multi-domain]  Cd Length: 64  Bit Score: 61.48  E-value: 8.02e-13
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 490261912   15 TSDVITQYLRRAILNGHFAENEPV-RQDEIAKKFNVSKIPVREALKKLEAEGLVVFVKNKGATV 77
Cdd:pfam00392   1 LYEQVYARLREDILSGRLRPGDKLpSERELAAEFGVSRTTVREALRRLEAEGLVERRQGRGTFV 64
PRK11534 PRK11534
DNA-binding transcriptional regulator CsiR; Provisional
 13-206 1.44e-12

DNA-binding transcriptional regulator CsiR; Provisional


Pssm-ID: 183181 [Multi-domain]  Cd Length: 224  Bit Score: 64.53  E-value: 1.44e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490261912  13 PSTSDVITQY--LRRAILNGHFAENEPVRQDEIAKKFNVSKIPVREALKKLEAEGLVVFVKNKGATVTRMSDDELAQLFE 90
Cdd:PRK11534   4 PMQITALDGYrwLKNDIIRGNFQPDEKLRMSLLTSRYALGVGPLREALSQLVAERLVTVVNQKGYRVASMSEQELLDIFD 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490261912  91 MRILLEVRLLELAIP---NMQMADFLHIEEVGNKYI----SDPNIMNWSALNWDFHLALYRAANRPLIVDSVKMINQKLE 163
Cdd:PRK11534  84 ARANMEAMLVSLAIArggDEWEADVLAKAHLLSKLEacdaSEKMLDEWDLRHQAFHTAIVAGCGSHYLLQMRERLFDLAA 163

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*..
gi 490261912 164 RY----LRMQLSLSNGKEKSDREHAEIISLCRQKNIPGAVDLLKKHI 206
Cdd:PRK11534 164 RYrfiwLRRTVLSVEMLEDKHDQHQTLTAAILARDTARASELMRQHL 210
HTH_GNTR smart00345
helix_turn_helix gluconate operon transcriptional repressor;
19-77 2.03e-09

helix_turn_helix gluconate operon transcriptional repressor;


Pssm-ID: 197669 [Multi-domain]  Cd Length: 60  Bit Score: 52.19  E-value: 2.03e-09
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 490261912    19 ITQYLRRAILNGHFAENEPVR-QDEIAKKFNVSKIPVREALKKLEAEGLVVFVKNKGATV 77
Cdd:smart00345   1 VAERLREDIVSGELRPGDKLPsERELAAQLGVSRTTVREALSRLEAEGLVQRRPGSGTFV 60
MngR COG2188
DNA-binding transcriptional regulator, GntR family [Transcription];
19-117 9.46e-09

DNA-binding transcriptional regulator, GntR family [Transcription];


Pssm-ID: 441791 [Multi-domain]  Cd Length: 238  Bit Score: 54.10  E-value: 9.46e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490261912  19 ITQYLRRAILNGHFAENEPV-RQDEIAKKFNVSKIPVREALKKLEAEGLVVFVKNKGATVTR----------MSDDELAQ 87
Cdd:COG2188   10 IADALRERIESGELPPGDRLpSERELAEEFGVSRMTVRKALDELVEEGLLERRQGRGTFVAEpkieyplsrlTSFTEELR 89

                         90       100       110
                 ....*....|....*....|....*....|
gi 490261912  88 LFEMRILLEVRLLELAIPNMQMADFLHIEE 117
Cdd:COG2188   90 ARGREPSTRVLSAERVPADEEVAEALGLPP 119
pdhR PRK09464
pyruvate dehydrogenase complex transcriptional repressor PdhR;
13-73 1.50e-08

pyruvate dehydrogenase complex transcriptional repressor PdhR;


Pssm-ID: 181879 [Multi-domain]  Cd Length: 254  Bit Score: 53.49  E-value: 1.50e-08
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 490261912  13 PSTSDVITQYLRRAILNGHFAENE---PVRqdEIAKKFNVSKIPVREALKKLEAEGLVV-------FVKNK 73
Cdd:PRK09464   9 PKLSDVIEQQLEFLILEGTLRPGEklpPER--ELAKQFDVSRPSLREAIQRLEAKGLLLrrqgggtFVQSS 77
MntR COG1321
Mn-dependent transcriptional regulator MntR, DtxR family [Transcription];
34-78 8.19e-07

Mn-dependent transcriptional regulator MntR, DtxR family [Transcription];


Pssm-ID: 440932 [Multi-domain]  Cd Length: 135  Bit Score: 46.74  E-value: 8.19e-07
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*
gi 490261912  34 ENEPVRQDEIAKKFNVSKIPVREALKKLEAEGLVVFVKNKGATVT 78
Cdd:COG1321   21 EGGPVRTSDIAERLGVSPPSVTEMLKKLEEKGLVEYEPYGGITLT 65
PRK09990 PRK09990
DNA-binding transcriptional regulator GlcC; Provisional
 16-215 1.01e-06

DNA-binding transcriptional regulator GlcC; Provisional


Pssm-ID: 182186 [Multi-domain]  Cd Length: 251  Bit Score: 48.22  E-value: 1.01e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490261912  16 SDVITQYLRRAILNGHFAENEPV-RQDEIAKKFNVSKIPVREALKKLEAEGLVVFVKNKGATVTRMSDDE---------- 84
Cdd:PRK09990   9 ADVVAERIERLIVDGVLKVGQALpSERRLCEKLGFSRSALREGLTVLRGRGIIETAQGRGSFVARLNRVQdasplmhlfs 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490261912  85 -----LAQLFEMRILLEVRLLELAIPNMQMADFLHI----EEV--GNKYISDPNIMNWSALNWDFHLALYRAANRPLIVD 153
Cdd:PRK09990  89 sqprtLYDLLEVRALLEGESARLAALRGTQADFVLItrryEEMlaAHENNKEIDPIEHARLDHAFHLAICEASHNPVLVH 168

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 490261912 154 SVKMINQKL---------ERYLRMQLslsngKEKSDREHAEIISLCRQKNIPGAVDLLKKHIYGVCQSLLD 215
Cdd:PRK09990 169 TLQSLTDLMlssvfasvnNLYHRPQQ-----KKQIDRQHARLYNAVLQRLPEQAQRAARDHIRTVRDNLRE 234
HTH_DTXR smart00529
Helix-turn-helix diphteria tox regulatory element; iron dependent repressor
 42-101 3.63e-05

Helix-turn-helix diphteria tox regulatory element; iron dependent repressor


Pssm-ID: 197774 [Multi-domain]  Cd Length: 95  Bit Score: 41.43  E-value: 3.63e-05
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 490261912    42 EIAKKFNVSKIPVREALKKLEAEGLVVFVKNKGATVTRMSDDELAQLFEMRILLEVRLLE 101
Cdd:smart00529   3 EIAERLNVSPPTVTEMLKKLEKMGLVEYEPYRGITLTEKGRRLARRLLRKHRLLERFLVD 62
ARO8 COG1167
DNA-binding transcriptional regulator, MocR family, contains an aminotransferase domain ...
 19-68 4.28e-05

DNA-binding transcriptional regulator, MocR family, contains an aminotransferase domain [Transcription, Amino acid transport and metabolism]; DNA-binding transcriptional regulator, MocR family, contains an aminotransferase domain is part of the Pathway/BioSystem: Lysine biosynthesis


Pssm-ID: 440781 [Multi-domain]  Cd Length: 471  Bit Score: 43.66  E-value: 4.28e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|...
gi 490261912  19 ITQYLRRAILNGHFAENE---PVRqdEIAKKFNVSKIPVREALKKLEAEGLVV 68
Cdd:COG1167   17 LADALREAILSGRLPPGDrlpSSR--ELAAQLGVSRSTVVRAYEELEAEGLIE 67
PRK10225 PRK10225
Uxu operon transcriptional regulator;
42-215 4.90e-05

Uxu operon transcriptional regulator;


Pssm-ID: 182318 [Multi-domain]  Cd Length: 257  Bit Score: 43.09  E-value: 4.90e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490261912  42 EIAKKFNVSKIPVREALKKLEAEGLV-------VFV-------KNKGATVTRMSDDELAQLFEMRILLEVRLLELA---- 103
Cdd:PRK10225  38 EIAEMLDVTRTVVREALIMLEIKGLVevrrgagIYVldssgshNTDSPDANVCNDAGPFELLQARQLLESNIAEFAalqa 117

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490261912 104 ----IPNMQMAdfLHIEEvgnKYISDPNIMNWSALNWDFHLALYRAANRPLIVDSVKMINQKLER---YLRMQLSLSNGK 176
Cdd:PRK10225 118 tredIVKMRQA--LQLEE---RELASSAPGSSESGDMQFHLAIAEATHNSMLVELFRQSWQWRENnpmWIQLHSHLDDSL 192

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|.
gi 490261912 177 EKSD--REHAEIISLCRQKNIPGAVDLLKKHIYGVCQSLLD 215
Cdd:PRK10225 193 YRKEwlGDHKQILAALIKKDARAAKLAMWQHLENVKQRLLE 233
PRK03837 PRK03837
transcriptional regulator NanR; Provisional
 16-206 2.24e-04

transcriptional regulator NanR; Provisional


Pssm-ID: 235166 [Multi-domain]  Cd Length: 241  Bit Score: 41.16  E-value: 2.24e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490261912  16 SDVITQYLRRAILNGHFAENEPV-RQDEIAKKFNVSKIPVREALKKLEAEGLVVFVKNKGATVTR--------------- 79
Cdd:PRK03837  15 SEEVEERLEQMIRSGEFGPGDQLpSERELMAFFGVGRPAVREALQALKRKGLVQISHGERARVSRpsadtiigqlsgmak 94

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490261912  80 ----MSDDELAQLFEMRILLEVRLLELAIPNM---QMADFLHIEEVGNKYISDPNimNWSALNWDFHLALYRAANRPLIV 152
Cdd:PRK03837  95 dflsQSPDGLAHLKQARLFFESSLARYAAEHAtdeQIALLRKALERNSQSLGDNA--AFIRSDMEFHRVIAEIPGNPIFM 172

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....
gi 490261912 153 DSVKMINQKLERYLRMQLSLSNGKEKSDREHAEIISLCRQKNIPGAVDLLKKHI 206
Cdd:PRK03837 173 AIHEALLDWLIEARPEVVILHGHENVTLQEHIAIVDAIRAHDPDEADRALQSHL 226
HTH_24 pfam13412
Winged helix-turn-helix DNA-binding;
23-67 4.59e-04

Winged helix-turn-helix DNA-binding;


Pssm-ID: 404317 [Multi-domain]  Cd Length: 45  Bit Score: 37.03  E-value: 4.59e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 490261912   23 LRRAILNgHFAENEPVRQDEIAKKFNVSKIPVREALKKLEAEGLV 67
Cdd:pfam13412   2 TDRKILN-LLQENPRISQRELAERLGLSPSTVNRRLKRLEEEGVI 45
HTH_ARSR cd00090
Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric ...
 24-71 7.27e-04

Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.


Pssm-ID: 238042 [Multi-domain]  Cd Length: 78  Bit Score: 37.28  E-value: 7.27e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*...
gi 490261912  24 RRAILngHFAENEPVRQDEIAKKFNVSKIPVREALKKLEAEGLVVFVK 71
Cdd:cd00090    9 RLRIL--RLLLEGPLTVSELAERLGLSQSTVSRHLKKLEEAGLVESRR 54
Fe_dep_repress pfam01325
Iron dependent repressor, N-terminal DNA binding domain; This family includes the Diphtheria ...
 34-75 8.59e-04

Iron dependent repressor, N-terminal DNA binding domain; This family includes the Diphtheria toxin repressor. DNA binding is through a helix-turn-helix motif.


Pssm-ID: 396062 [Multi-domain]  Cd Length: 57  Bit Score: 36.58  E-value: 8.59e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 490261912   34 ENEPVRQDEIAKKFNVSKIPVREALKKLEAEGLVVFVKNKGA 75
Cdd:pfam01325  16 EKGVVKTKDLAERLNVSPSTVSEMLKKLEKMGYVDYEPYKGL 57
DeoR COG2390
DNA-binding transcriptional regulator LsrR, DeoR family [Transcription];
35-89 1.28e-03

DNA-binding transcriptional regulator LsrR, DeoR family [Transcription];


Pssm-ID: 441955 [Multi-domain]  Cd Length: 301  Bit Score: 38.96  E-value: 1.28e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 490261912  35 NEPVRQDEIAKKFNVSKIPVREALKKLEAEGLV-VFVKNKGATVTRMSdDELAQLF 89
Cdd:COG2390    8 VEGLTQREIAERLGISRRTVSRLLAEAREEGLVrISITDPLAGLLELE-RELRERF 62
COG2345 COG2345
Predicted transcriptional regulator, ArsR family [Transcription];
24-68 1.40e-03

Predicted transcriptional regulator, ArsR family [Transcription];


Pssm-ID: 441914 [Multi-domain]  Cd Length: 217  Bit Score: 38.75  E-value: 1.40e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*
gi 490261912  24 RRAILNgHFAENEPVRQDEIAKKFNVSKIPVREALKKLEAEGLVV 68
Cdd:COG2345   15 RRRILE-LLKRAGPVTAAELAEALGLTPNAVRRHLDALEEEGLVE 58
HTH_27 pfam13463
Winged helix DNA-binding domain;
22-68 5.18e-03

Winged helix DNA-binding domain;


Pssm-ID: 433228 [Multi-domain]  Cd Length: 68  Bit Score: 34.57  E-value: 5.18e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 490261912   22 YLRRAILNGHFAENEPVRQDEIAKKFNVSKIPVREALKKLEAEGLVV 68
Cdd:pfam13463   3 RLEALILHNIGHRGDPKTLADICFRLNVEDSHVSYSLKKLTEAGLVE 49
COG3888 COG3888
Predicted transcriptional regulator [Transcription];
36-68 6.24e-03

Predicted transcriptional regulator [Transcription];


Pssm-ID: 443096 [Multi-domain]  Cd Length: 328  Bit Score: 36.92  E-value: 6.24e-03
                         10        20        30
                 ....*....|....*....|....*....|...
gi 490261912  36 EPVRQDEIAKKFNVSKIPVREALKKLEAEGLVV 68
Cdd:COG3888   18 EGIPQSELVRLLGASKSRVSEILSELEKEGLIA 50
COG3398 COG3398
Predicted transcriptional regulator, contains two HTH domains [Transcription];
22-85 6.50e-03

Predicted transcriptional regulator, contains two HTH domains [Transcription];


Pssm-ID: 442625 [Multi-domain]  Cd Length: 159  Bit Score: 36.01  E-value: 6.50e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 490261912  22 YLR----RAILnGHFAENEPVRQDEIAKKFNVSKIPVREALKKLEAEGLVVFVKNKGATVTRMSDDEL 85
Cdd:COG3398   93 YLRretpRRIL-LYLLENPGATNKELAEELGISRSTVSWHLKRLEEDGLVERERDGRNVRYYLNPPER 159
MarR_2 pfam12802
MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a ...
 30-74 6.98e-03

MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a non-specific resistance system. The expression of the mar operon is controlled by a repressor, MarR. A large number of compounds induce transcription of the mar operon. This is thought to be due to the compound binding to MarR, and the resulting complex stops MarR binding to the DNA. With the MarR repression lost, transcription of the operon proceeds. The structure of MarR is known and shows MarR as a dimer with each subunit containing a winged-helix DNA binding motif.


Pssm-ID: 432797 [Multi-domain]  Cd Length: 60  Bit Score: 34.10  E-value: 6.98e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 490261912   30 GHFAENEPVRQDEIAKKFNVSKIPVREALKKLEAEGLVVFVKNKG 74
Cdd:pfam12802  12 LALARNPGLTVAELARRLGISKQTVSRLVKRLEAKGLVEREPSPA 56
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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