NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|490246888|ref|WP_004145049|]
View 

MULTISPECIES: phosphonate utilization transcriptional regulator PhnR [Klebsiella]

Protein Classification

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
phnR super family cl31335
phosphonate utilization transcriptional regulator PhnR; This family of proteins are members of ...
 9-239 4.44e-140

phosphonate utilization transcriptional regulator PhnR; This family of proteins are members of the GntR family (pfam00392) containing an N-terminal helix-turn-helix (HTH) motif. This clade is found adjacent to or inside of operons for the degradation of 2-aminoethylphosphonate (AEP) in Salmonella, Vibrio Aeromonas hydrophila, Hahella chejuensis and Psychromonas ingrahamii. [Regulatory functions, DNA interactions]


The actual alignment was detected with superfamily member TIGR03337:

Pssm-ID: 132380 [Multi-domain]  Cd Length: 231  Bit Score: 391.88  E-value: 4.44e-140
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490246888    9 PQYLMIKAQLQARIQNGALKSGDKLPSERELCALFNTTRITVRESLAQLEASGVIYRADRRGWFVTPERLWLDPTQNTNF 88
Cdd:TIGR03337   1 PQYLYIKDHLSYQIRAGALLPGDKLPSERDLGERFNTTRVTIREALQQLEAEGLIYREDRRGWFVSPPRLRYNPTRTQNF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490246888   89 HKLCLEQGREPKTVLLDGRLAAVPLDVMAPLALQPFDQVYLLTRLRYADGRPVCYCENHCLPARVPELLRHDLNGSLTEI 168
Cdd:TIGR03337  81 HEYVREQGREPKTELIGVTVTPAPARMAELLQLQPFDRLFLLQRLRYADGRPVCYCENYILPARVPGLLKEDLNGSLTEI 160

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 490246888  169 YQTHYDLIYTSMHLSFYPTSMPPQAAEALGVMEGRPALLLRRLNYDQHGRILDYDIEYWRHDSLRIEVDTH 239
Cdd:TIGR03337 161 YRNHYGLVYHSMNLRFKPTALLEEAAQALGATAGLPALHLERTNYDQHGRVLDLDIEYWRHDALTIEVDTN 231
 
Name Accession Description Interval E-value
phnR TIGR03337
phosphonate utilization transcriptional regulator PhnR; This family of proteins are members of ...
 9-239 4.44e-140

phosphonate utilization transcriptional regulator PhnR; This family of proteins are members of the GntR family (pfam00392) containing an N-terminal helix-turn-helix (HTH) motif. This clade is found adjacent to or inside of operons for the degradation of 2-aminoethylphosphonate (AEP) in Salmonella, Vibrio Aeromonas hydrophila, Hahella chejuensis and Psychromonas ingrahamii. [Regulatory functions, DNA interactions]


Pssm-ID: 132380 [Multi-domain]  Cd Length: 231  Bit Score: 391.88  E-value: 4.44e-140
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490246888    9 PQYLMIKAQLQARIQNGALKSGDKLPSERELCALFNTTRITVRESLAQLEASGVIYRADRRGWFVTPERLWLDPTQNTNF 88
Cdd:TIGR03337   1 PQYLYIKDHLSYQIRAGALLPGDKLPSERDLGERFNTTRVTIREALQQLEAEGLIYREDRRGWFVSPPRLRYNPTRTQNF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490246888   89 HKLCLEQGREPKTVLLDGRLAAVPLDVMAPLALQPFDQVYLLTRLRYADGRPVCYCENHCLPARVPELLRHDLNGSLTEI 168
Cdd:TIGR03337  81 HEYVREQGREPKTELIGVTVTPAPARMAELLQLQPFDRLFLLQRLRYADGRPVCYCENYILPARVPGLLKEDLNGSLTEI 160

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 490246888  169 YQTHYDLIYTSMHLSFYPTSMPPQAAEALGVMEGRPALLLRRLNYDQHGRILDYDIEYWRHDSLRIEVDTH 239
Cdd:TIGR03337 161 YRNHYGLVYHSMNLRFKPTALLEEAAQALGATAGLPALHLERTNYDQHGRVLDLDIEYWRHDALTIEVDTN 231
MngR COG2188
DNA-binding transcriptional regulator, GntR family [Transcription];
5-237 9.25e-73

DNA-binding transcriptional regulator, GntR family [Transcription];


Pssm-ID: 441791 [Multi-domain]  Cd Length: 238  Bit Score: 221.27  E-value: 9.25e-73
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490246888   5 SGEMPQYLMIKAQLQARIQNGALKSGDKLPSERELCALFNTTRITVRESLAQLEASGVIYRADRRGWFVTPERLWLDPTQ 84
Cdd:COG2188    1 SSPVPLYLQIADALRERIESGELPPGDRLPSERELAEEFGVSRMTVRKALDELVEEGLLERRQGRGTFVAEPKIEYPLSR 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490246888  85 NTNFHKLCLEQGREPKTVLLDGRLAAVPLDVMAPLALQPFDQVYLLTRLRYADGRPVCYCENHCLPARVPELLRHDL-NG 163
Cdd:COG2188   81 LTSFTEELRARGREPSTRVLSAERVPADEEVAEALGLPPGAPVLRIERLRLADGEPVALETSYLPAALFPGLLEEDLeTG 160

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 490246888 164 SLTEIYQTHYDLIYTSMHLSFYPTSMPPQAAEALGVMEGRPALLLRRLNYDQHGRILDYDIEYWRHDSLRIEVD 237
Cdd:COG2188  161 SLYELLEERYGLRITRAEQRIEAVLADAEEAELLGVPPGAPVLVIERVTYDADGRPVEYSRSYYRGDRYRFVVE 234
UTRA pfam07702
UTRA domain; The UbiC transcription regulator-associated (UTRA) domain is a conserved ...
 94-233 9.48e-39

UTRA domain; The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain that has a similar fold to pfam04345. It is believed to modulate activity of bacterial transcription factors in response to binding small molecules sugar phosphates and urocanate, Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).


Pssm-ID: 429607 [Multi-domain]  Cd Length: 141  Bit Score: 131.18  E-value: 9.48e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490246888   94 EQGREPKTVLLDGRLAAVPLDVMAPLALQPFDQVYLLTRLRYADGRPVCYCENHCLPARVPELLRHDL-NGSLTEIYQTH 172
Cdd:pfam07702   1 AQGREPKTEVLSLEEVPASAEIAEALGLPPGEPVYRIERLRYADGEPVALEEDYLPAELVPDLLEEDLeEGSLYDYLEER 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 490246888  173 YDLIYTSMHLSFYPTSMPPQAAEALGVMEGRPALLLRRLNYDQHGRILDYDIEYWRHDSLR 233
Cdd:pfam07702  81 YGLPITRAEQTIEAVLADAEEAELLGISPGAPVLLIERVTYDQDGRPVEYSRSYYRGDRYR 141
UTRA smart00866
The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; ...
 94-230 6.25e-33

The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; It has a similar fold to HutC/FarR-like bacterial transcription factors of the GntR family. It is believed to modulate activity of bacterial transcription factors in response to binding small molecules.


Pssm-ID: 214869 [Multi-domain]  Cd Length: 143  Bit Score: 116.62  E-value: 6.25e-33
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490246888    94 EQGREPKTVLLDGRLAAVPLDVMAPLALQPFDQVYLLTRLRYADGRPVCYCENHCLPARVPELLRHDLNGSLTEIYQTHY 173
Cdd:smart00866   1 AQGRKPTTKVLSFERVPADEELAEALGLPPGDPVYRIERLRLADGEPVALETTYLPAALFPGLLEEDLSGSLYEYLEERL 80

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 490246888   174 DL---IYTSMHLSFYPTSMPPQAAEALGVMEGRPALLLRRLNYDQHGRILDYDIEYWRHD 230
Cdd:smart00866  81 GLkivRSTRAEQTITAVLADEEEAELLGLPPGAPLLVVERVTYDDDGRPVEYSRSYYRGD 140
WHTH_GntR cd07377
Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional ...
 9-74 3.11e-23

Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; This CD represents the winged HTH DNA-binding domain of the GntR (named after the gluconate operon repressor in Bacillus subtilis) family of bacterial transcriptional regulators and their putative homologs found in eukaryota and archaea. The GntR family has over 6000 members distributed among almost all bacterial species, which is comprised of FadR, HutC, MocR, YtrA, AraR, PlmA, and other subfamilies for the regulation of the most varied biological process. The monomeric proteins of the GntR family are characterized by two function domains: a small highly conserved winged helix-turn-helix prokaryotic DNA binding domain in the N-terminus, and a very diverse regulatory ligand-binding domain in the C-terminus for effector-binding/oligomerization, which provides the basis for the subfamily classifications. Binding of the effector to GntR-like transcriptional regulators is presumed to result in a conformational change that regulates the DNA-binding affinity of the repressor. The GntR-like proteins bind as dimers, where each monomer recognizes a half-site of 2-fold symmetric DNA sequences.


Pssm-ID: 153418 [Multi-domain]  Cd Length: 66  Bit Score: 89.04  E-value: 3.11e-23
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 490246888   9 PQYLMIKAQLQARIQNGALKSGDKLPSERELCALFNTTRITVRESLAQLEASGVIYRADRRGWFVT 74
Cdd:cd07377    1 PLYEQIADQLREAILSGELKPGDRLPSERELAEELGVSRTTVREALRELEAEGLVERRPGRGTFVA 66
PRK11402 PRK11402
transcriptional regulator PhoB;
9-179 5.52e-21

transcriptional regulator PhoB;


Pssm-ID: 183118 [Multi-domain]  Cd Length: 241  Bit Score: 87.97  E-value: 5.52e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490246888   9 PQYLMIKAQLQARIQNGALKSGDKLPSERELCALFNTTRITVRESLAQLEASGVIYRADRRGWFVTPERLWLDPTQNTNF 88
Cdd:PRK11402   9 LLYATVRQRLLDDIAQGVYQAGQQIPTENELCTQYNVSRITIRKAISDLVADGVLIRWQGKGTFVQSQKVENALLTVSGF 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490246888  89 HKLCLEQGREPKT-VLLDGRLAAVPLDVMapLALQPFDQVYLLTRLRYADGRPVCYCENHCLPARVPELLRHDLNG-SLT 166
Cdd:PRK11402  89 TDFGVSQGKATKEkVIEQERVSAAPFCEK--LNIPGNSEVFHLCRVMYLDKEPLFIDSSWIPLSRYPDFDEIYVEGsSTY 166

                        170
                 ....*....|...
gi 490246888 167 EIYQTHYDLIYTS 179
Cdd:PRK11402 167 QLFQERFDTRVVS 179
 
Name Accession Description Interval E-value
phnR TIGR03337
phosphonate utilization transcriptional regulator PhnR; This family of proteins are members of ...
 9-239 4.44e-140

phosphonate utilization transcriptional regulator PhnR; This family of proteins are members of the GntR family (pfam00392) containing an N-terminal helix-turn-helix (HTH) motif. This clade is found adjacent to or inside of operons for the degradation of 2-aminoethylphosphonate (AEP) in Salmonella, Vibrio Aeromonas hydrophila, Hahella chejuensis and Psychromonas ingrahamii. [Regulatory functions, DNA interactions]


Pssm-ID: 132380 [Multi-domain]  Cd Length: 231  Bit Score: 391.88  E-value: 4.44e-140
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490246888    9 PQYLMIKAQLQARIQNGALKSGDKLPSERELCALFNTTRITVRESLAQLEASGVIYRADRRGWFVTPERLWLDPTQNTNF 88
Cdd:TIGR03337   1 PQYLYIKDHLSYQIRAGALLPGDKLPSERDLGERFNTTRVTIREALQQLEAEGLIYREDRRGWFVSPPRLRYNPTRTQNF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490246888   89 HKLCLEQGREPKTVLLDGRLAAVPLDVMAPLALQPFDQVYLLTRLRYADGRPVCYCENHCLPARVPELLRHDLNGSLTEI 168
Cdd:TIGR03337  81 HEYVREQGREPKTELIGVTVTPAPARMAELLQLQPFDRLFLLQRLRYADGRPVCYCENYILPARVPGLLKEDLNGSLTEI 160

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 490246888  169 YQTHYDLIYTSMHLSFYPTSMPPQAAEALGVMEGRPALLLRRLNYDQHGRILDYDIEYWRHDSLRIEVDTH 239
Cdd:TIGR03337 161 YRNHYGLVYHSMNLRFKPTALLEEAAQALGATAGLPALHLERTNYDQHGRVLDLDIEYWRHDALTIEVDTN 231
MngR COG2188
DNA-binding transcriptional regulator, GntR family [Transcription];
5-237 9.25e-73

DNA-binding transcriptional regulator, GntR family [Transcription];


Pssm-ID: 441791 [Multi-domain]  Cd Length: 238  Bit Score: 221.27  E-value: 9.25e-73
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490246888   5 SGEMPQYLMIKAQLQARIQNGALKSGDKLPSERELCALFNTTRITVRESLAQLEASGVIYRADRRGWFVTPERLWLDPTQ 84
Cdd:COG2188    1 SSPVPLYLQIADALRERIESGELPPGDRLPSERELAEEFGVSRMTVRKALDELVEEGLLERRQGRGTFVAEPKIEYPLSR 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490246888  85 NTNFHKLCLEQGREPKTVLLDGRLAAVPLDVMAPLALQPFDQVYLLTRLRYADGRPVCYCENHCLPARVPELLRHDL-NG 163
Cdd:COG2188   81 LTSFTEELRARGREPSTRVLSAERVPADEEVAEALGLPPGAPVLRIERLRLADGEPVALETSYLPAALFPGLLEEDLeTG 160

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 490246888 164 SLTEIYQTHYDLIYTSMHLSFYPTSMPPQAAEALGVMEGRPALLLRRLNYDQHGRILDYDIEYWRHDSLRIEVD 237
Cdd:COG2188  161 SLYELLEERYGLRITRAEQRIEAVLADAEEAELLGVPPGAPVLVIERVTYDADGRPVEYSRSYYRGDRYRFVVE 234
UTRA pfam07702
UTRA domain; The UbiC transcription regulator-associated (UTRA) domain is a conserved ...
 94-233 9.48e-39

UTRA domain; The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain that has a similar fold to pfam04345. It is believed to modulate activity of bacterial transcription factors in response to binding small molecules sugar phosphates and urocanate, Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).


Pssm-ID: 429607 [Multi-domain]  Cd Length: 141  Bit Score: 131.18  E-value: 9.48e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490246888   94 EQGREPKTVLLDGRLAAVPLDVMAPLALQPFDQVYLLTRLRYADGRPVCYCENHCLPARVPELLRHDL-NGSLTEIYQTH 172
Cdd:pfam07702   1 AQGREPKTEVLSLEEVPASAEIAEALGLPPGEPVYRIERLRYADGEPVALEEDYLPAELVPDLLEEDLeEGSLYDYLEER 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 490246888  173 YDLIYTSMHLSFYPTSMPPQAAEALGVMEGRPALLLRRLNYDQHGRILDYDIEYWRHDSLR 233
Cdd:pfam07702  81 YGLPITRAEQTIEAVLADAEEAELLGISPGAPVLLIERVTYDQDGRPVEYSRSYYRGDRYR 141
UTRA smart00866
The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; ...
 94-230 6.25e-33

The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; It has a similar fold to HutC/FarR-like bacterial transcription factors of the GntR family. It is believed to modulate activity of bacterial transcription factors in response to binding small molecules.


Pssm-ID: 214869 [Multi-domain]  Cd Length: 143  Bit Score: 116.62  E-value: 6.25e-33
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490246888    94 EQGREPKTVLLDGRLAAVPLDVMAPLALQPFDQVYLLTRLRYADGRPVCYCENHCLPARVPELLRHDLNGSLTEIYQTHY 173
Cdd:smart00866   1 AQGRKPTTKVLSFERVPADEELAEALGLPPGDPVYRIERLRLADGEPVALETTYLPAALFPGLLEEDLSGSLYEYLEERL 80

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 490246888   174 DL---IYTSMHLSFYPTSMPPQAAEALGVMEGRPALLLRRLNYDQHGRILDYDIEYWRHD 230
Cdd:smart00866  81 GLkivRSTRAEQTITAVLADEEEAELLGLPPGAPLLVVERVTYDDDGRPVEYSRSYYRGD 140
WHTH_GntR cd07377
Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional ...
 9-74 3.11e-23

Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; This CD represents the winged HTH DNA-binding domain of the GntR (named after the gluconate operon repressor in Bacillus subtilis) family of bacterial transcriptional regulators and their putative homologs found in eukaryota and archaea. The GntR family has over 6000 members distributed among almost all bacterial species, which is comprised of FadR, HutC, MocR, YtrA, AraR, PlmA, and other subfamilies for the regulation of the most varied biological process. The monomeric proteins of the GntR family are characterized by two function domains: a small highly conserved winged helix-turn-helix prokaryotic DNA binding domain in the N-terminus, and a very diverse regulatory ligand-binding domain in the C-terminus for effector-binding/oligomerization, which provides the basis for the subfamily classifications. Binding of the effector to GntR-like transcriptional regulators is presumed to result in a conformational change that regulates the DNA-binding affinity of the repressor. The GntR-like proteins bind as dimers, where each monomer recognizes a half-site of 2-fold symmetric DNA sequences.


Pssm-ID: 153418 [Multi-domain]  Cd Length: 66  Bit Score: 89.04  E-value: 3.11e-23
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 490246888   9 PQYLMIKAQLQARIQNGALKSGDKLPSERELCALFNTTRITVRESLAQLEASGVIYRADRRGWFVT 74
Cdd:cd07377    1 PLYEQIADQLREAILSGELKPGDRLPSERELAEELGVSRTTVREALRELEAEGLVERRPGRGTFVA 66
C_P_lyase_phnF TIGR02325
phosphonates metabolism transcriptional regulator PhnF; All members of the seed alignment for ...
 11-235 2.80e-22

phosphonates metabolism transcriptional regulator PhnF; All members of the seed alignment for this family are predicted helix-turn-helix transcriptional regulatory proteins of the broader gntR and are found associated with genes for the import and degradation of phosphonates and/or related compounds (e.g. phosphonites) with a direct C-P bond. [Transport and binding proteins, Anions, Regulatory functions, DNA interactions]


Pssm-ID: 131378 [Multi-domain]  Cd Length: 238  Bit Score: 91.38  E-value: 2.80e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490246888   11 YLMIKAQLQARIQNGALKSGDKLPSERELCALFNTTRITVRESLAQLEASGVIYRADRRGWFVTPERLWLDPTQNTNFHK 90
Cdd:TIGR02325  10 WRQIADKIEQEIAAGHLRAGDYLPAEMQLAERFGVNRHTVRRAIAALVERGLLRAEQGRGTFVAARRIDYPLSARTRFSQ 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490246888   91 LCLEQGREPKTVLLDGRLAAVPLDVMAPLALQPFDQVYLLTRLRYADGRPVCYCENHCLPARVPELL-RHDLNGSLTEIY 169
Cdd:TIGR02325  90 NLADQGREPTGELLLSDLEPASAELADALGLTVGAPLVRLETLRKADGRPLCRATTWFPAARFPGIGqAYAASGSITDAL 169

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490246888  170 --QTHYDLIYTSMHLSfyptSMPPQAAEA--LGVMEGRPALLLRRLNYDQHGRILDYDIEYWRHDslRIE 235
Cdd:TIGR02325 170 reQGVADYRRSSTRIS----ARHADAKDCarLELPPGRPLLVVQALNHDGEGRPVQYSVSRFRAD--RVE 233
PRK11402 PRK11402
transcriptional regulator PhoB;
9-179 5.52e-21

transcriptional regulator PhoB;


Pssm-ID: 183118 [Multi-domain]  Cd Length: 241  Bit Score: 87.97  E-value: 5.52e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490246888   9 PQYLMIKAQLQARIQNGALKSGDKLPSERELCALFNTTRITVRESLAQLEASGVIYRADRRGWFVTPERLWLDPTQNTNF 88
Cdd:PRK11402   9 LLYATVRQRLLDDIAQGVYQAGQQIPTENELCTQYNVSRITIRKAISDLVADGVLIRWQGKGTFVQSQKVENALLTVSGF 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490246888  89 HKLCLEQGREPKT-VLLDGRLAAVPLDVMapLALQPFDQVYLLTRLRYADGRPVCYCENHCLPARVPELLRHDLNG-SLT 166
Cdd:PRK11402  89 TDFGVSQGKATKEkVIEQERVSAAPFCEK--LNIPGNSEVFHLCRVMYLDKEPLFIDSSWIPLSRYPDFDEIYVEGsSTY 166

                        170
                 ....*....|...
gi 490246888 167 EIYQTHYDLIYTS 179
Cdd:PRK11402 167 QLFQERFDTRVVS 179
GntR pfam00392
Bacterial regulatory proteins, gntR family; This family of regulatory proteins consists of the ...
 11-73 1.19e-18

Bacterial regulatory proteins, gntR family; This family of regulatory proteins consists of the N-terminal HTH region of GntR-like bacterial transcription factors. At the C-terminus there is usually an effector-binding/oligomerization domain. The GntR-like proteins include the following sub-families: MocR, YtrR, FadR, AraR, HutC and PlmA, DevA, DasR. Many of these proteins have been shown experimentally to be autoregulatory, enabling the prediction of operator sites and the discovery of cis/trans relationships. The DasR regulator has been shown to be a global regulator of primary metabolism and development in Streptomyces coelicolor.


Pssm-ID: 306822 [Multi-domain]  Cd Length: 64  Bit Score: 76.88  E-value: 1.19e-18
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 490246888   11 YLMIKAQLQARIQNGALKSGDKLPSERELCALFNTTRITVRESLAQLEASGVIYRADRRGWFV 73
Cdd:pfam00392   2 YEQVYARLREDILSGRLRPGDKLPSERELAAEFGVSRTTVREALRRLEAEGLVERRQGRGTFV 64
HTH_GNTR smart00345
helix_turn_helix gluconate operon transcriptional repressor;
14-73 2.19e-18

helix_turn_helix gluconate operon transcriptional repressor;


Pssm-ID: 197669 [Multi-domain]  Cd Length: 60  Bit Score: 76.07  E-value: 2.19e-18
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 490246888    14 IKAQLQARIQNGALKSGDKLPSERELCALFNTTRITVRESLAQLEASGVIYRADRRGWFV 73
Cdd:smart00345   1 VAERLREDIVSGELRPGDKLPSERELAAQLGVSRTTVREALSRLEAEGLVQRRPGSGTFV 60
trehalos_R_Bsub TIGR02404
trehalose operon repressor, B. subtilis-type; This family consists of repressors of the GntR ...
 10-170 1.91e-16

trehalose operon repressor, B. subtilis-type; This family consists of repressors of the GntR family typically associated with trehalose utilization operons. Trehalose is imported as trehalose-6-phosphate and then hydrolyzed by alpha,alpha-phosphotrehalase to glucose and glucose-6-P. This family includes repressors mostly from Gram-positive lineages and does not include the TreR from E. coli. [Regulatory functions, DNA interactions]


Pssm-ID: 274116 [Multi-domain]  Cd Length: 233  Bit Score: 75.48  E-value: 1.91e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490246888   10 QYLMIKAQLQARIQNGALKSGDKLPSERELCALFNTTRITVRESLAQLEASGVIYRADRRGWFV-TPERLWLDPTQNTNF 88
Cdd:TIGR02404   1 KYEQIYQDLEQKITKGQYKEGDYLPSEHELMDQYGASRETVRKALNLLTERGYIQKIQGKGSIVlNRKQIEFPISGITSF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490246888   89 HKLCLEQGREPKT-VLLDGRLAAVPLDVMAPLALQPFDQVYLLTRLRYADGRPVCYCENHCLPARVPELLRHDLNGSlte 167
Cdd:TIGR02404  81 KELNETLGLDSKTeVVELDKEDPLPETLAQLTGLEEGSLIWRIKRVRVIDGEAVILDIDYLLKELVPGLTKEIAEDS--- 157


                  ...
gi 490246888  168 IYQ 170
Cdd:TIGR02404 158 IYQ 160
FadR COG2186
DNA-binding transcriptional regulator, FadR family [Transcription];
16-79 4.34e-16

DNA-binding transcriptional regulator, FadR family [Transcription];


Pssm-ID: 441789 [Multi-domain]  Cd Length: 232  Bit Score: 74.58  E-value: 4.34e-16
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 490246888  16 AQLQARIQNGALKSGDKLPSERELCALFNTTRITVRESLAQLEASGVIYRADRRGWFVTPERLW 79
Cdd:COG2186   14 EQLRELILSGELKPGDRLPSERELAEQLGVSRTTVREALRALEALGLVEVRQGGGTFVREPSPW 77
PRK09764 PRK09764
GntR family transcriptional regulator;
6-233 9.46e-16

GntR family transcriptional regulator;


Pssm-ID: 182065 [Multi-domain]  Cd Length: 240  Bit Score: 73.71  E-value: 9.46e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490246888   6 GEMPQYLMIKAQLQARIQNGALKSGDKLPSERELCALFNTTRITVRESLAQLEASGVIYRADRRGWFVTPERLWLDPTQN 85
Cdd:PRK09764   2 GHKPLYRQIADRIREQIARGELKPGDALPTESALQTEFGVSRVTVRQALRQLVEQQILESIQGSGTYVKEERVNYDIFQL 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490246888  86 TNFH-KLCLEQGREPKTVLLdgrLAAVPLD--VMAPLALQPFDQVYLLTRLRYADGRPVCYcENHCLPARvpelLRHDLN 162
Cdd:PRK09764  82 TSFDeKLSDRHVDTHSEVLI---FEVIPADdfLQQQLQITAQDRVWHVKRVRYRKQKPMAL-EETWMPLA----LFPDLT 153

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 490246888 163 GSLTEIYQTHY-----DLIYTSMHLSFYPTSMPPQAAEALGVMEGRPALLLRRLNYDQHGRILDYDIEYWRHDSLR 233
Cdd:PRK09764 154 WQVMENSKYHFieevkKMVIDRSEQEIIPLMPTEEMSRLLNISQTKPILEKVSRGYLVDGRVFEYSRNAFNTDDYK 229
ARO8 COG1167
DNA-binding transcriptional regulator, MocR family, contains an aminotransferase domain ...
 3-77 1.08e-15

DNA-binding transcriptional regulator, MocR family, contains an aminotransferase domain [Transcription, Amino acid transport and metabolism]; DNA-binding transcriptional regulator, MocR family, contains an aminotransferase domain is part of the Pathway/BioSystem: Lysine biosynthesis


Pssm-ID: 440781 [Multi-domain]  Cd Length: 471  Bit Score: 75.64  E-value: 1.08e-15
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 490246888   3 SPSGEMPQYLMIKAQLQARIQNGALKSGDKLPSERELCALFNTTRITVRESLAQLEASGVIYRADRRGWFVTPER 77
Cdd:COG1167    6 DRDSSGPLYLQLADALREAILSGRLPPGDRLPSSRELAAQLGVSRSTVVRAYEELEAEGLIESRPGSGTFVAARL 80
YhcF COG1725
DNA-binding transcriptional regulator YhcF, GntR family [Transcription];
3-75 5.11e-14

DNA-binding transcriptional regulator YhcF, GntR family [Transcription];


Pssm-ID: 441331 [Multi-domain]  Cd Length: 114  Bit Score: 65.97  E-value: 5.11e-14
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 490246888   3 SPSGEMPQYLMIKAQLQARIQNGALKSGDKLPSERELCALFNTTRITVRESLAQLEASGVIYRADRRGWFVTP 75
Cdd:COG1725    4 DFDSGVPIYEQIADQIKEAIASGELKPGDRLPSVRELAAELGVNPNTVAKAYRELEDEGLIETRRGKGTFVAE 76
GntR COG1802
DNA-binding transcriptional regulator, GntR family [Transcription];
1-75 9.35e-11

DNA-binding transcriptional regulator, GntR family [Transcription];


Pssm-ID: 441407 [Multi-domain]  Cd Length: 222  Bit Score: 59.55  E-value: 9.35e-11
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 490246888   1 MKSPSGEMPQYL--MIKAQLQARIQNGALKSGDKLpSERELCALFNTTRITVRESLAQLEASGVIYRADRRGWFVTP 75
Cdd:COG1802    1 MTSPSPLRRESLaeQVYEALREAILSGELPPGERL-SEAELAERLGVSRTPVREALRRLEAEGLVEIRPNRGARVAP 76
pdhR PRK09464
pyruvate dehydrogenase complex transcriptional repressor PdhR;
14-79 4.53e-10

pyruvate dehydrogenase complex transcriptional repressor PdhR;


Pssm-ID: 181879 [Multi-domain]  Cd Length: 254  Bit Score: 58.11  E-value: 4.53e-10
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 490246888  14 IKAQLQARIQNGALKSGDKLPSERELCALFNTTRITVRESLAQLEASGVIYRADRRGWFVTpERLW 79
Cdd:PRK09464  15 IEQQLEFLILEGTLRPGEKLPPERELAKQFDVSRPSLREAIQRLEAKGLLLRRQGGGTFVQ-SSLW 79
PRK10079 PRK10079
phosphonate metabolism transcriptional regulator PhnF; Provisional
 4-230 1.03e-08

phosphonate metabolism transcriptional regulator PhnF; Provisional


Pssm-ID: 182227 [Multi-domain]  Cd Length: 241  Bit Score: 54.01  E-value: 1.03e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490246888   4 PSGEMPQYLMIKAQLQARIQnGALKSGDKLPSERELCALFNTTRITVRESLAQLEASGVIYRADRRGWFVTPERLWLDPT 83
Cdd:PRK10079   7 PTSYPTRYQEIAAKLEQELR-QHYRCGDYLPAEQQLAARYEVNRHTLRRAIDQLVEKGWVQRRQGVGVLVLMRPYDYPLN 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490246888  84 QNTNFHKLCLEQGREPKTVLLDGRLAAVPLDVMAPLALQPFDQVYLLTRLRYADGRPVCYCeNHCLP-ARVPELLRHDLN 162
Cdd:PRK10079  86 AQARFSQNLLDQGSHPTSEKLLSVLRPASGHVADALGITEGENVIHLRTLRRVNGVALCLI-DHYFAdLTWWPTLQRFDS 164

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 490246888 163 GSLTEIYQTHydliyTSMHLSFYPTSMPPQAAEA-----LGVMEGRPALLLRRLNY-DQHGRILDYDIEYWRHD 230
Cdd:PRK10079 165 GSLHDFLREQ-----LGIALRRSQTRISARRAQAkesqlLEIPNMSPLLCVRTLNHrDGESSPAEYSVSLTRAD 233
PRK03837 PRK03837
transcriptional regulator NanR; Provisional
 13-63 1.08e-08

transcriptional regulator NanR; Provisional


Pssm-ID: 235166 [Multi-domain]  Cd Length: 241  Bit Score: 53.87  E-value: 1.08e-08
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|.
gi 490246888  13 MIKAQLQARIQNGALKSGDKLPSERELCALFNTTRITVRESLAQLEASGVI 63
Cdd:PRK03837  17 EVEERLEQMIRSGEFGPGDQLPSERELMAFFGVGRPAVREALQALKRKGLV 67
PRK10421 PRK10421
DNA-binding transcriptional repressor LldR; Provisional
 17-70 7.18e-08

DNA-binding transcriptional repressor LldR; Provisional


Pssm-ID: 236690 [Multi-domain]  Cd Length: 253  Bit Score: 51.69  E-value: 7.18e-08
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....
gi 490246888  17 QLQARIQNGALKSGDKLPSERELCALFNTTRITVRESLAQLEASGVIyrADRRG 70
Cdd:PRK10421  10 RVRALIEEKNLEAGMKLPAERQLAMQLGVSRNSLREALAKLVSEGVL--LSRRG 61
PRK09990 PRK09990
DNA-binding transcriptional regulator GlcC; Provisional
 22-110 3.21e-06

DNA-binding transcriptional regulator GlcC; Provisional


Pssm-ID: 182186 [Multi-domain]  Cd Length: 251  Bit Score: 46.68  E-value: 3.21e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490246888  22 IQNGALKSGDKLPSERELCALFNTTRITVRESLAQLEASGVIYRADRRGWFVTpeRLWLDPTQNTNFHKLcleqGREPKT 101
Cdd:PRK09990  20 IVDGVLKVGQALPSERRLCEKLGFSRSALREGLTVLRGRGIIETAQGRGSFVA--RLNRVQDASPLMHLF----SSQPRT 93

                         90       100
                 ....*....|....*....|
gi 490246888 102 V--------LLDG---RLAA 110
Cdd:PRK09990  94 LydllevraLLEGesaRLAA 113
PRK10225 PRK10225
Uxu operon transcriptional regulator;
1-70 5.31e-06

Uxu operon transcriptional regulator;


Pssm-ID: 182318 [Multi-domain]  Cd Length: 257  Bit Score: 46.17  E-value: 5.31e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490246888   1 MKSPSGEMPQYLMIKAQLQARIQNGALKSGDKLPSERELCALFNTTRITVRESLAQLEASGVIyrADRRG 70
Cdd:PRK10225   1 MKSATSAQRPYQEVGAMIRDLIIKTPYNPGERLPPEREIAEMLDVTRTVVREALIMLEIKGLV--EVRRG 68
PRK11523 PRK11523
transcriptional regulator ExuR;
11-63 7.10e-06

transcriptional regulator ExuR;


Pssm-ID: 183176 [Multi-domain]  Cd Length: 253  Bit Score: 45.99  E-value: 7.10e-06
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|...
gi 490246888  11 YLMIKAQLQARIQNGALKSGDKLPSERELCALFNTTRITVRESLAQLEASGVI 63
Cdd:PRK11523  10 YQQLAAELKERIEQGVYLVGDKLPAERFIADEKNVSRTVVREAIIMLEVEGYV 62
PRK14999 PRK14999
histidine utilization repressor; Provisional
 2-73 8.32e-06

histidine utilization repressor; Provisional


Pssm-ID: 184961 [Multi-domain]  Cd Length: 241  Bit Score: 45.69  E-value: 8.32e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 490246888   2 KSPSGEMPQYLMIKAQLQARIQNGALKSGDKLPSERELCALFNTTRITVRESLAQLEASGVIYRADRRGWFV 73
Cdd:PRK14999   5 RSRSAPAPFYETVKQDICKKIAGGVWQPHDRIPSEAELVAQYGFSRMTINRALRELTDEGWLVRLQGVGTFV 76
HTH_41 pfam14502
Helix-turn-helix domain;
28-70 1.97e-03

Helix-turn-helix domain;


Pssm-ID: 433997 [Multi-domain]  Cd Length: 48  Bit Score: 35.16  E-value: 1.97e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 490246888   28 KSGDKLPSERELCALFNTTRITVRESLAQLEASGVIYrADRRG 70
Cdd:pfam14502   1 KAGERLPTISEYSHKFELSVGTVQKALKKLEDMKAIQ-LERRG 42
PRK04984 PRK04984
fatty acid metabolism transcriptional regulator FadR;
2-71 6.18e-03

fatty acid metabolism transcriptional regulator FadR;


Pssm-ID: 179909 [Multi-domain]  Cd Length: 239  Bit Score: 36.77  E-value: 6.18e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490246888   2 KSPSGEMPQYLmIKAqlqarIQNGALKSGDKLPSERELCALFNTTRITVREslaqleasgVIYRADRRGW 71
Cdd:PRK04984   6 QSPAGFAEEYI-IES-----IWNNRFPPGSILPAERELSELIGVTRTTLRE---------VLQRLARDGW 60
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH