|
Name |
Accession |
Description |
Interval |
E-value |
| MFS_OPA_SLC37 |
cd17312 |
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ... |
29-435 |
1.30e-123 |
|
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340870 [Multi-domain] Cd Length: 364 Bit Score: 363.90 E-value: 1.30e-123
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490232023 29 RWQTFITMTLAYVTFYVCRLSFTVAKSALVE-LGITPTELGMIGSTLFFSYAIGKLVNGFIADHANVVRYMSLGLLLSAG 107
Cdd:cd17312 1 RWRIFLGVFLGYAAYYVCRKNFSVAKPPIVEeIGLSKDDLGIIGSAFLIAYAVGKFISGFLSDRSNIRRFMSAGLLLSAL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490232023 108 MNLMMGMTSNAMLLAIFWGINGWAQSMGVGPCVVSLARWYGCKERGTFYAIWSTAHNIGEAMTYMVIAAVIAGFGWQMGY 187
Cdd:cd17312 81 ANIFMGFSTSLWFFAVLWGLNGLFQSMGWPPCVKLLGNWFSKKERGTVYGIWSTSHNFGGILAPILAASLASYYGWRAAF 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490232023 188 LSTAALGAAGVVLMLLFMRDSPqscgfpsinvirdepleeteargsvfknqllalrnPALWTLALASAFMYIDRYAVNSW 267
Cdd:cd17312 161 LVPGIVGLVVAIILFFFLRDSP-----------------------------------PYVWVLSLAYAFVYIVRYACLDW 205
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490232023 268 GIFFLEQDKAYSTLEASGIIGVNAIAGIAGTIIAGMLSDRFFPRNRSVMAGFISLLNTAGFALMLWSPHGYYTDILAMII 347
Cdd:cd17312 206 GPLYLYEVKGYSLIDAGWFSSLYEVGGIAGTILAGLLSDKLFGGRRAPIAVIYMLLMTLSLALFWFFPHNKLLSIVLLFL 285
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490232023 348 FGATIGALTCFLGGLIAVDISSRKAAGAALGTIGIASYAGAGLGEFLTGIIIDKtsmiengktlYDFSTLSLFWVGTGLM 427
Cdd:cd17312 286 IGFFVGGPINLIGGAAAQDIGRKEAAGTATGFVGLFGYLGASLAGLPLGYIIDH----------YGWSTVFYFLISAALL 355
|
....*...
gi 490232023 428 SALFCFTT 435
Cdd:cd17312 356 SVLLLLSL 363
|
|
| MFS_GlpT |
cd17345 |
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; ... |
29-401 |
6.56e-74 |
|
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; Glycerol-3-Phosphate Transporter (also called GlpT or G-3-P permease) is responsible for glycerol-3-phosphate uptake. It is part of the Organophosphate:Pi antiporter (OPA) family of integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The GlpT group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340903 [Multi-domain] Cd Length: 411 Bit Score: 237.91 E-value: 6.56e-74
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490232023 29 RWQTFITMTLAYVTFYVCRLSFTVAKSALVE-LGITPTELGMIGSTLFFSYAIGKLVNGFIADHANVVRYMSLGLLLSAG 107
Cdd:cd17345 1 RWQVFLGIFIGYAGYYLVRNNFSLAQPYLIEqYGLSKTEIGLIGSALSIAYGLSKFVMGNLSDRSNPKRFLAIGLILSAI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490232023 108 MNLMMGMTSNAM----LLAIFWGINGWAQSMGVGPCVVSLARWYGCKERGTFYAIWSTAHNIGEAMTYMVIAAVIAGFG- 182
Cdd:cd17345 81 INILIGFVPSATssvgLMFILLFLNGWFQGMGWPPSGRTMVHWFSKKERGTWTSIWNISHNVGGGLVGPLAGLGLAIFGd 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490232023 183 -WQMGYLSTAALGAAGV-VLMLLFMRDSPQSCGFPSINVIRDEplEETEARGSVFKNQLLA--------LRNPALWTLAL 252
Cdd:cd17345 161 gWWRGAFIFPAIIAIIVaVIVLFLGKDTPESEGLPPIEEYKGD--YPEEADGEEEEQELSAweifvkyvLKNKLLWYIAI 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490232023 253 ASAFMYIDRYAVNSWGIFFLEQDKAYSTLEASGIIGVNAIAGIAGTIIAGMLSDRFFPRNRSVMaGFISLLNTAGFALML 332
Cdd:cd17345 239 ANVFVYLVRYGILDWAPTYLSEVKGFSKAQAMWAFSLFEWAAIPGTLLAGWLSDKLFKGRRAPT-GIIFMILVIVALIVY 317
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490232023 333 WSPHGYYTDILAMIIFGATIGAlTCFLGGLIAVDISSRKAAGAALGTIGIASY-AGAGLGEFLTGIIIDK 401
Cdd:cd17345 318 WLAPNVLVDLIALIALGFLIYG-PVMLIGLQALELVPKKAAGTAAGLTGLFGYlGGSVLATALIGIIVDH 386
|
|
| PRK11663 |
PRK11663 |
glucose-6-phosphate receptor/MFS transporter UhpC; |
22-400 |
8.56e-59 |
|
glucose-6-phosphate receptor/MFS transporter UhpC;
Pssm-ID: 183266 [Multi-domain] Cd Length: 434 Bit Score: 199.17 E-value: 8.56e-59
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490232023 22 EQRFRSVRWQTFITMTLAYVTFYVCRLSFTVAKSA-LVELGITPTELGMIGSTLFFSYAIGKLVNGFIADHANVVRYMSL 100
Cdd:PRK11663 14 DARYRYWRRHILITMYLGYALFYFTRKSFNAAMPEmLADLGLSRSDIGLLATLFYITYGVSKFVSGIVSDRSNARYFMGI 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490232023 101 GLLLSAGMNLMMGMTSNAMLLAIFWGINGWAQSMGVGPCVVSLARWYGCKERGTFYAIWSTAHNIGEAMTYMVIAAVIAG 180
Cdd:PRK11663 94 GLIATGIINILFGFSSSLWAFALLWVLNAFFQGWGWPVCAKLLTAWYSRTERGGWWAIWNTAHNVGGALIPLVVGAIALH 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490232023 181 FGWQMGYLSTAALGAAGVVLMLLFMRDSPQSCGFPSINVIRDEPLE---ETEARGSVFKNQL--LALRNPALWTLALASA 255
Cdd:PRK11663 174 YGWRYGMMIAGIIAIVVGLFLCWRLRDKPQAMGLPSVGEWRHDALElaqQQEGAGLSRKEILtkYVLLNPYIWLLSFSYV 253
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490232023 256 FMYIDRYAVNSWGIFFLEQDKAYSTLEASGIIGVNAIAGIAGTIIAGMLSDRFFPRNRSVMAGFIS---LLNTAGFALMl 332
Cdd:PRK11663 254 LVYVVRAAINDWGNLYMSETLGVDLVTANSAVSMFELGGFIGALVAGWGSDKLFNGNRGPMNLIFAagiLLSVGSLWLM- 332
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 490232023 333 wsPHGYYTdILAMIIFgaTIGALTC---FLGGLIAVDISSRKAAGAALGTIGIASYAGAGLGEFLTGIIID 400
Cdd:PRK11663 333 --PFASYV-MQAACFF--TIGFFVFgpqMLIGMAAAECSHKEAAGAATGFVGLFAYLGAALSGYPLAKVLE 398
|
|
| 2A0104 |
TIGR00881 |
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ... |
37-403 |
6.63e-57 |
|
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273319 [Multi-domain] Cd Length: 379 Bit Score: 192.59 E-value: 6.63e-57
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490232023 37 TLAYVTFYVCRLSFTVAKSALVE-LGITPTELGMIGSTLFFSYAIGKLVNGFIADHANVVRYMSLGLLLSAGMNLMMGMT 115
Cdd:TIGR00881 1 FIGYAAYYLVRKNFALAMPYLVEeIGLSKTDLGLLLSSFSIAYGISKFVMGSVSDRSNPRVFLPIGLILCAIVNLFFGFS 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490232023 116 SNAMLLAIFWGINGWAQSMGVGPCVVSLARWYGCKERGTFYAIWSTAHNIGEAMTYMVIAAVIAGF-GWQMGYLSTAALG 194
Cdd:TIGR00881 81 TSLWVMAALWALNGIFQGMGWPPCGRTVTKWFSRSERGTWVSFWNCSHNVGGGLLPPLVLFGIAELySWHWVFIVPGIIA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490232023 195 AAGVVLMLLFMRDSPQSCGFPSINvirDEPLEETEARGSVFKNQLLA--------LRNPALWTLALASAFMYIDRYAVNS 266
Cdd:TIGR00881 161 IIVSLICFLLLRDSPQSCGLPPAE---EMPNEEPDGDAEKKEEELTKkqiflqyvLLNKVLWYISLGYVFVYVVRTGILD 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490232023 267 WGIFFLEQDKAYSTLEASGIIGVNAIAGIAGTIIAGMLSDRFFPRNRSVMAGFISLLNTAGFALMLWSPHGyytDILAMI 346
Cdd:TIGR00881 238 WSPLYLTQEKGFSKEKASWAFTLYELGGLVGTLLAGWLSDKLFNGRRGPLAVFFMALIIVSLLVYWLNPAA---NPLMDL 314
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|
gi 490232023 347 IFGATIGALT---CFLGGLIAVDISSRKAAGAALGTIGIASYAGAGLGEFLTGIIIDKTS 403
Cdd:TIGR00881 315 ICLFALGFLVygpQMLIGVIASELAPKKAAGTAAGFVGFFAYLGGILAGLPLGYLADGFG 374
|
|
| glpT |
PRK11273 |
glycerol-3-phosphate transporter; |
5-387 |
4.17e-51 |
|
glycerol-3-phosphate transporter;
Pssm-ID: 236889 [Multi-domain] Cd Length: 452 Bit Score: 179.13 E-value: 4.17e-51
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490232023 5 IIAFFRASPPKA---GGEFDeQRFRSVRWQTFITMTLAYVTFYVCRLSFTVAKSALVELGITPTELGMIGSTLFFSYAIG 81
Cdd:PRK11273 1 MLSIFKPAPHKArlpAAEID-PTYRRLRWQIFLGIFFGYAAYYLVRKNFALAMPYLVEQGFSRGDLGFALSGISIAYGFS 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490232023 82 KLVNGFIADHANVVRYMSLGLLLSAGMNLMMGM----TSNAMLLAIFWGINGWAQSMGVGPCVVSLARWYGCKERGTFYA 157
Cdd:PRK11273 80 KFIMGSVSDRSNPRVFLPAGLILAAAVMLFMGFvpwaTSSIAVMFVLLFLCGWFQGMGWPPCGRTMVHWWSQKERGGIVS 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490232023 158 IWSTAHNIGEAMTYMVIAAVIAGFG-WQMGYLSTAALGAAGVVLMLLFMRDSPQSCGFPSINVIR-------DEPLEETE 229
Cdd:PRK11273 160 VWNCAHNVGGGLPPLLFLLGMAWFNdWHAALYMPAFAAILVALFAFAMMRDTPQSCGLPPIEEYKndypddyNEKHEQEL 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490232023 230 ARGSVFKNQLlaLRNPALWTLALASAFMYIDRYAVNSWGIFFLEQDKAYSTLEASGIIGVNAIAGIAGTIIAGMLSDRFF 309
Cdd:PRK11273 240 TAKQIFMQYV--LPNKLLWYIAIANVFVYLLRYGILDWSPTYLKEVKHFALDKSSWAYFLYEYAGIPGTLLCGWMSDKVF 317
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 490232023 310 PRNRSVMAGFISLLNTAGFALMLWSPHGYYT-DILAMIIFGATIGAlTCFLGGLIAVDISSRKAAGAALGTIGIASYAG 387
Cdd:PRK11273 318 RGNRGATGVFFMTLVTIATIVYWLNPAGNPTvDMACMIVIGFLIYG-PVMLIGLHALELAPKKAAGTAAGFTGLFGYLG 395
|
|
| MFS_UhpC |
cd17488 |
Membrane sensor protein UhpC of the Major Facilitator Superfamily of transporters; Membrane ... |
29-400 |
5.79e-51 |
|
Membrane sensor protein UhpC of the Major Facilitator Superfamily of transporters; Membrane sensor protein UhpC acts as both a sensor and a transport protein. It is part of the UhpABC signaling cascade that controls the expression of the hexose phosphate transporter UhpT. UhpC recognizes external glucose-6-phosphate (Glc6P) and induces transport by UhpT. It can also transport and sense Glc6P, and interacts with the histidine kinase UhpB, leading to the stimulation of the autokinase activity of UhpB. This group also includes the hexose phosphate transport protein UhpT from Chlamydia pneumoniae; it is a transport protein for sugar phosphate uptake. It is part of the Organophosphate:Pi antiporter (OPA) family of integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The UhpC group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341041 [Multi-domain] Cd Length: 364 Bit Score: 176.44 E-value: 5.79e-51
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490232023 29 RWQTFITMTLAYVTFYVCRLSFTVAKSALV-ELGITPTELGMIGSTLFFSYAIGKLVNGFIADHANVVRYMSLGLLLSAG 107
Cdd:cd17488 1 RIHILASMFIGYAVFYLTRKSFNAAMPAMLaDLGLDKSDIGILGSLFYITYGVSKFVSGLMSDRSNPRYFMGIGLIATGI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490232023 108 MNLMMGMTSNAMLLAIFWGINGWAQSMGVGPCVVSLARWYGCKERGTFYAIWSTAHNIGEAMTYMVIAAVIAGFGWQMGY 187
Cdd:cd17488 81 INILFGFSSSLWAFAVLWTLNAFFQGWGWPPCARLLTHWYSRNERGFWWSIWNTSHNIGGALIPILTGFAALTYGWRAGM 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490232023 188 LstaalgAAGVVLMLLfmrdspqscGFPSINVIRDEPleeteargsvfknqllalrnPALWTLALASAFMYIDRYAVNSW 267
Cdd:cd17488 161 Y------VPGIIAILM---------GIVLCWRLRDRP--------------------PYIWLLAFCYVLVYVVRTAINDW 205
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490232023 268 GIFFLEQDKAYSTLEASGIIGVNAIAGIAGTIIAGMLSDRFFPRNRSVMAGFISLLNTAGFALMLWSPHGYYTdILAMII 347
Cdd:cd17488 206 GNLYLSETHGYSLVKANSAVSLFEVGGLIGALVAGWGSDKLFKGNRGPMNLIFALGLLVSVGALWLVPVHSYW-LLATCF 284
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*.
gi 490232023 348 FgaTIGALTC---FLGGLIAVDISSRKAAGAALGTIGIASYAGAGLGEFLTGIIID 400
Cdd:cd17488 285 F--TIGFFVFgpqMLIGMAAAECSHKDAAGSATGFVGLFAYLGAALAGYPLAKVIE 338
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
22-404 |
4.06e-44 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 158.11 E-value: 4.06e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490232023 22 EQRFRSVRWQTFITMTLAYVTFYVCRLSFTVAKSALV-ELGITPTELGMIGSTLFFSYAIGKLVNGFIADHANVVRYMSL 100
Cdd:COG2271 1 ARAPSRYRWRILALLFLAYFLNYLDRSNLSVAAPPLQaDLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490232023 101 GLLLSAGMNLMMGMTSNAMLLAIFWGINGWAQSMGVGPCVVSLARWYGCKERGTFYAIWSTAHNIGEAMTYMVIAAVIAG 180
Cdd:COG2271 81 GLLLWGLATLLFGFATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490232023 181 FGWQMGYLSTAALGAAGVVLmllfmrdspqscgfpsinvirdepleeteargsvfknqllalrnpALWTLALASAFMYID 260
Cdd:COG2271 161 FGWRAAFLILGLPGLLLALL---------------------------------------------RFWLLALAYFLVYFA 195
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490232023 261 RYAVNSWGIFFLEQDKAYSTLEASGIIGVNAIAGIAGTIIAGMLSDRFFPRNRSVMAGFISLlnTAGFALMLWSPHGYYT 340
Cdd:COG2271 196 LYGFLTWLPTYLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRRKLVLAIGLLL--AALALLLLALLPSPAL 273
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 490232023 341 DILAMIIFGATIGALTCFLGGLIAvDISSRKAAGAALGTIGIASYAGAGLGEFLTGIIIDKTSM 404
Cdd:COG2271 274 AIALLFLAGFGLGGAFGLLWALAA-ELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATGY 336
|
|
| MFS_SLC37A4 |
cd17343 |
Solute carrier family 37 member 4 of the Major Facilitator Superfamily of transporters; Solute ... |
29-365 |
1.22e-37 |
|
Solute carrier family 37 member 4 of the Major Facilitator Superfamily of transporters; Solute carrier family 37 member 4 (SLC37A4), one of four SLC37 family proteins in vertebrates, is better known as glucose-6-phosphate transporter (G6PT). It is also called sugar phosphate exchanger 4 (SPX4), G6P translocase, or transformation-related gene 19 protein (TRG-19). G6PT is a phosphate (Pi)-linked G6P antiporter, catalyzing G6P:Pi and Pi:Pi exchanges. Deficiencies in human G6PT lead to glycogen storage disease type Ib (GSD-Ib), which is a metabolic and immune disorder. G6PT is a member of the Organophosphate:Pi antiporter (OPA)/SLC37 family, whose members are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340901 [Multi-domain] Cd Length: 409 Bit Score: 141.70 E-value: 1.22e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490232023 29 RWQTFITMTLAYVTFYVCRLSFTVAKSALV-ELGITPTELGMIGSTLFFSYAIGKLVNGFIADHANVVRYMSLGLLLSAG 107
Cdd:cd17343 1 QLTIFASMFVGYTLYYFNRKSFSFVLPSLMnELGLDKSDLGLITSSQSLAYAISKFIGGVLSDQISARWLFSSGLVLSGL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490232023 108 MNLMMGMTSNAMLLAIFWGINGWAQSMGVGPCVVSLARWYGCKERGTFYAIWSTAHNIGEAMTYMVIAAVIAGFGWQMGY 187
Cdd:cd17343 81 TTVAFSGSSSVWVFSILWFLNGLAQGLGWPPCAKILRKWFSPSQFGTWWSVLSTSMNLAGSLGPILATLLALSYGWRSTL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490232023 188 LSTAALGAAGVVLMLLFMRDSPQSCGFPSINVIRDEPLEETEARGSVFKNQLlaLRNPALWTLALASAFMYIDRYAVNSW 267
Cdd:cd17343 161 SISGTVAVVMSVVCLLFIKNEPSDVGLNNIEEEESKGKKKKSPRGESTLKEL--LLSPFLWLLSLGYLVVFGVKTAVTDW 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490232023 268 GIFFLEQDKAYSTLEASGIIGVNAIAGIAGTIIAGMLSDRFFPRNRSVMAG----FISLLNTAGFALMLWSPH---GYYT 340
Cdd:cd17343 239 GQLFLIQDKGQSALTGSSFMSSLEVGGFVGSIAAGYLSDWAVAKHGSSSRGnprmPLALVFMAGLTVSLHLFRvhiTSDS 318
|
330 340
....*....|....*....|....*
gi 490232023 341 DILAMIIFGATIGaltCFLGGLIAV 365
Cdd:cd17343 319 SELFILLLGFLIG---FSLYGPIAI 340
|
|
| uhpT |
PRK09556 |
hexose-6-phosphate:phosphate antiporter; |
7-440 |
1.10e-35 |
|
hexose-6-phosphate:phosphate antiporter;
Pssm-ID: 236564 [Multi-domain] Cd Length: 467 Bit Score: 137.49 E-value: 1.10e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490232023 7 AFFRASPPKAGGEFDEQRFRSVR--WQTFITMTLAYVTFYVCRLSFTVAKSALVE-LGITPTELGMIGSTLFFSYAIGKL 83
Cdd:PRK09556 3 FLNQVRKPTLDLPLEVQRKMWFKpfMQSYLVVFIGYLTMYLIRKNFKAAQNDMIStYGLSTTELGMIGLGFSITYGVGKT 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490232023 84 VNGFIADHANVVRYMSLGLLLSA----GMNLMMGMTSNAM-LLAIFWGINGWAQSMGvGPCVVS-LARWYGCKERGTFYA 157
Cdd:PRK09556 83 LVGYYADGKNTKQFLPFLLILSAicmlGFGASLGSGSVSLgLMIALWALSGFFQSTG-GPCSYStITRWTPRRKRGRFLG 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490232023 158 IWSTAHNIGEAmtymvIAAVIAGFGWQ-------MGYLSTAALGAAGV-VLMLLFMRDSPQSCGFPSINVIRDEPLEETE 229
Cdd:PRK09556 162 FWNISHNLGGA-----GAGGVALWGANyffdghvIGMFIFPSIIALIIgFIGLRYGSDSPEELGWGKAEEIFGEPISEED 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490232023 230 A--------RGSVFKNQLlaLRNPALWTLALASAFMYIDRYAVNSWGIFFLEQDKAYSTLEASGIIGVNAIAGIAGTIIA 301
Cdd:PRK09556 237 KetestdmtKWQIFVEYV--LKNPVIWLLCFANIFLYIVRIGIDNWSPVYAFQELGFSKEDAINTFTLFEIGALVGSLLW 314
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490232023 302 GMLSDRFFPRNRSVMAGFISLLntaGFALMLW----SPHGYYTD--ILAMIIFGATIgaltcfLGGLIAVDISSRKAAGA 375
Cdd:PRK09556 315 GWLSDLANGRRALVACIALALI---IFTLGVYqhatSEYMYLASlfALGFLVFGPQL------LIGVAAVGFVPKKAIGV 385
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 490232023 376 ALGTIGIASYA-GAGLGEFLTGIIIDKTSmieNGKTLydFSTLSLFWVGTGL---MSALFCFTTAAIVA 440
Cdd:PRK09556 386 ANGIKGTFAYLfGDSFAKVGLGMIADPTK---NGTPI--FGYTLTGWAGTFAaldIAAIGCICLMAIVA 449
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
27-402 |
3.67e-27 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 112.28 E-value: 3.67e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490232023 27 SVRWQTFITMTLAYVTFYVCRLSFTVAKSALVE-LGITPTELGMIGSTLFFSYAIGKLVNGFIADHANVVRYMSLGLLLS 105
Cdd:COG2223 1 SGRWRVLLLATLAFFLAFGVWYLWSVLAPPLAEeFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490232023 106 AGMNLMMGMTSNAMLLAIFWGINGWAQSMGVGPCVVSLARWYGCKERGTFYAIWSTAHNIGEAMTYMVIAAVIAGFGWQM 185
Cdd:COG2223 81 GIGLLLLALAVSYWLLLLLGLLLGIGGGGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGWRN 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490232023 186 GYLSTAALGAAGVVLMLLFMRDSPQscgfpsinvirdeplEETEARGSVFKNQLLALRNPALWTLALASAFMYIDRYAVN 265
Cdd:COG2223 161 AFLILGILLLVVAVLAWLFLRDPPA---------------GAAAAAKASLRDQLEALRDPRFWLLSLLYFGTFGSFIGFS 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490232023 266 SWGIFFLEQDKAYSTLEASGIIGVNAIAGIAGTIIAGMLSDRfFPRNRSVMAGFIslLNTAGFALMLWSPHGYYTDILAM 345
Cdd:COG2223 226 SWLPPYLVDQFGLSAATAGLLAALFALLGALGRPLGGWLSDR-IGGRRVLLIVFA--LMALGLLLLALALGSLWLFLVLF 302
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*..
gi 490232023 346 IIFGATIGALTCFLGGLIAvDISSRKAAGAALGTIGIASYAGAGLGEFLTGIIIDKT 402
Cdd:COG2223 303 LLLGLALGGGNGAVFALVP-DIFPTKNAGAVYGLVGAAGGLGGFLGPLLFGALLDAT 358
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
59-403 |
1.51e-24 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 104.63 E-value: 1.51e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490232023 59 ELGITPTELGMIGSTLFFSYAIGKLVNGFIADHANVVRYMSLGLLLSAGMNLMMGMTSNAMLLAIFWGINGwaqsMGVGP 138
Cdd:cd17475 25 DLHLSLAQVGLLLSALNLGVAVSMLPAGWLLDRFGERRVLAVGLLLMGAAALLMALVGSYPVLLVLLFLVG----AGYGS 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490232023 139 CVVS----LARWYGCKERGTFYAIWSTAHNIGEAMTYMVIAAVIAGFGWQMGYLSTAALGAAGVVLMLLFMRDSPqscgf 214
Cdd:cd17475 101 VQPGggraIMRWFPPRERGLAMGIRQTGVPLGGALAAALLPPLALHYGWRAAFVVAGLVSILAAVLFWLFYREPP----- 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490232023 215 psinvirdEPLEETEARGSVFKNQLLALRNPALWTLALASAFMYIDRYAVNSWGIFFLEQDKAYSTLEASGIIGVNAIAG 294
Cdd:cd17475 176 --------AASAATESASTLLRSLKEVLRNRDVWLIAIAGALLVAPQFALLTFLLLFLHDHLGLSVVAAGALLAVAQLGG 247
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490232023 295 IAGTIIAGMLSDRFFPRNRSVMAGFISLLNTAGFALMLWSPHGyyTDILAMIIFGATIGALTCFLGGL---IAVDISSRK 371
Cdd:cd17475 248 ALGRIGLGRVSDRVFGGRRRPVLVITAAIAAAALLVLSLLSPG--TPLWLLVLLLILLGLFAIGWNGLyltLVAESAGPE 325
|
330 340 350
....*....|....*....|....*....|..
gi 490232023 372 AAGAALGTIGIASYAGAGLGEFLTGIIIDKTS 403
Cdd:cd17475 326 QAGTALGLANTINFIGIAIGPPLFGLLVDATH 357
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
32-391 |
5.45e-24 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 102.50 E-value: 5.45e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490232023 32 TFITMTLAYVTFYVcrLSFTVAKSALVELGITPTELGMIGSTLFFSYAIGKLVNGFIADHANVVRYMSLGLLLSAGMNLM 111
Cdd:pfam07690 1 LFLAAFLAALGRSL--LGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLL 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490232023 112 MGMTSNAMLLAIFWGINGWAQSMGVGPCVVSLARWYGCKERGTFYAIWSTAHNIGEAMTYMVIAAVIAGFGWQMGYLSTA 191
Cdd:pfam07690 79 LLFASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILA 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490232023 192 ALGAAGVVLMLLFMRDSPqscgfpsinviRDEPLEETEARGSVFKNQLLALRNPALWTLALASAFMYIdRYAVNSWgIFF 271
Cdd:pfam07690 159 ILSLLAAVLLLLPRPPPE-----------SKRPKPAEEARLSLIVAWKALLRDPVLWLLLALLLFGFA-FFGLLTY-LPL 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490232023 272 LEQDKAYSTLEASGIIGVNAIAGIAGTIIAGMLSDRFFPRNRSVMAGFISLLNTAGFALMLWsPHGYYTDILAMIIFGAT 351
Cdd:pfam07690 226 YQEVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLILAALGLLLLSL-TLSSLWLLLALLLLGFG 304
|
330 340 350 360
....*....|....*....|....*....|....*....|
gi 490232023 352 IGALTCFLGGLIAvDISSRKAAGAALGTIGIASYAGAGLG 391
Cdd:pfam07690 305 FGLVFPALNALVS-DLAPKEERGTASGLYNTAGSLGGALG 343
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
29-390 |
1.09e-23 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 101.59 E-value: 1.09e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490232023 29 RWQTFITMTLAYVTFYVCRLSFTVAKSALV-ELGITPTELGMIGSTLFFSYAIGKLVNGFIADHANVVRYMSLGLLLSAG 107
Cdd:COG2814 8 RWLALLALALGAFLSGLGIGIVLPALPLIAaDLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFAL 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490232023 108 MNLMMGMTSNAMLLAIFWGINGWAQSMGVGPCVVSLARWYGCKERGTFYAIWSTAHNIGEAMTYMVIAAVIAGFGWQMGY 187
Cdd:COG2814 88 GSLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWRWVF 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490232023 188 LSTAALGAAGVVLMLLFMRDSPQscgfpsinvirdepleetEARGSVFKNQLLALRNPALWTLALASAFMYIDRYAVNSW 267
Cdd:COG2814 168 LVNAVLALLALLLLLRLLPESRP------------------AARARLRGSLRELLRRPRLLLLLLLAFLLGFGFFALFTY 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490232023 268 GIFFLEQDKAYSTLEASGIIGVNAIAGIAGTIIAGMLSDRFFPRNRSVMAGFISLLntaGFALMLWSPHgYYTDILAMII 347
Cdd:COG2814 230 LPLYLQEVLGLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLAL---GLLLLALAGS-LWLLLLALFL 305
|
330 340 350 360
....*....|....*....|....*....|....*....|...
gi 490232023 348 FGATIGALTCFLGGLIAvDISSRKAAGAALGTIGIASYAGAGL 390
Cdd:COG2814 306 LGFGFGLLFPLLQALVA-ELAPPEARGRASGLYNSAFFLGGPL 347
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
29-402 |
5.62e-22 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 96.87 E-value: 5.62e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490232023 29 RWQTFITMTLAYVTFYVCRLSFTVAKSALV-ELGITPTELGMIGSTLFFSYAIGKLVNGFIADHANVVRYMSLGLLLSAG 107
Cdd:cd17319 1 RWRIIPLLFLAYVINYLDRVNISVAAPTIMkDLGLSPTQYGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490232023 108 MNLMMGMTSNAMLLAIFWGINGWAQSMGVGPCVVSLARWYGCKERGTFYAIWSTAHNIGEAMTYMVIAAVIAGFGWQMGY 187
Cdd:cd17319 81 FTALTGFATSLTSLYVLRFLLGVAEAGFFPGAIKALAEWFPARERGRATGLFNSGAPLGAAIGPPLSGWLLLLFGWRWAF 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490232023 188 LstaALGAAGVVLMLLFmrdspqscgfpsinvirdepleeteargsvfknqllALRNPALWTLALASAFMYIDRYAVNSW 267
Cdd:cd17319 161 I---IEGLLGLLLAVLW------------------------------------WFYLRQVWGLALGYFGINYALYGLLTW 201
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490232023 268 GIFFLEQDKAYSTLEASGIIGVNAIAGIAGTIIAGMLSDRFFPRNRSVMAGFISLLNTAGFALMLWSPHGYytdiLAMII 347
Cdd:cd17319 202 LPTYLKQARGFSLKQVGLLAAIPFLAGAIGMILGGRLSDRLLRGARRLVIIIGLLLAAVGLLLAYLTTSPV----VAVIL 277
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*..
gi 490232023 348 FGATIGALTCFLGGLIAV--DISSRKAAGAALGTIGIASYAGAGLGEFLTGIIIDKT 402
Cdd:cd17319 278 LSLAGFGIGAASPVFWSLpaDLLPGEAAATAGGLINSGGNLGGFVAPLLIGYLVDAT 334
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
59-402 |
5.70e-22 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 97.25 E-value: 5.70e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490232023 59 ELGITPTELGMIGSTLFFSYAIGKLVNGFIADHANVVRYMSLGLLLSAGMNLMMGMTSNAMLLAIFWGINGWAQSMGVGP 138
Cdd:COG2807 47 DLGLSATQAGLLTTLPLLAFGLFAPLAPRLARRFGLERTLLLALLLLAAGLLLRSLAPSVALLLAGTALIGAGIAVGNVL 126
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490232023 139 CVVSLARWYGcKERGTFYAIWSTAHNIGEAMTYMVIAAVIAGFGWQMGYLSTAALGAAGVVLMLLFMRDSPqscgfpsin 218
Cdd:COG2807 127 LPGLIKRWFP-DRVGLMTGLYTAAMGLGAALAAGLTVPLAAALGWRGALAVWALLALLALLLWLPLLRRRP--------- 196
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490232023 219 viRDEPLEETEARGsvfknqLLALRNPALWTLALASAFMYIDRYAVNSWGIFFLeQDKAYSTLEASGIIGVNAIAGIAGT 298
Cdd:COG2807 197 --AAAAAAPAAASL------RSLWRSPLAWLLTLFFGLQSLLYYAVVAWLPPIL-RDAGLSAATAGLLLSLFQLAGIPGS 267
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490232023 299 IIAGMLSDRFfpRNRSVMAGFISLLNTAGFALMLWSPHGYYtdILAMIIFGATIGALTCFLGGLIAVDISSRKAAGAALG 378
Cdd:COG2807 268 LLVPLLADRL--GDRRPLLLLLGLLGLAGLLGLLLAPGSLP--WLWAVLLGLGQGGLFPLALTLIGLRARTPAEAAALSG 343
|
330 340
....*....|....*....|....
gi 490232023 379 TIGIASYAGAGLGEFLTGIIIDKT 402
Cdd:COG2807 344 MAQSVGYLLAALGPLLVGALHDAT 367
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
56-402 |
1.92e-20 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 92.72 E-value: 1.92e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490232023 56 ALVELGITPTELGMIGSTLFFSYAIGKLVNGFIADHANVVRYMSLGLLLSAGMNLMMGMTSNAMLLAIFWGINGWAQS-M 134
Cdd:cd17355 29 IIAEFGWSRAVISLAFTVGLLAFGLAQPFVGRLLDRFGPRRVMLLGLLLLAAGLVLLALATSLWQLYLLWGLLGGGGAgT 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490232023 135 GVGPCVVSLARWYGCKERGTFYAIWSTAHNIGEAMTYMVIAAVIAGFGWQMGYLSTAALGAAGVVLMLLFMRDSPQSCGF 214
Cdd:cd17355 109 LAAVAFATVAAWWFERRRGLALGILTAGGGLGSLVFLPLGAALIEAFGWRTALLVLALLALLVLVPVLLLLRRRPADLAL 188
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490232023 215 PSINVIRDEPLEETEARgsvfknqllALRNPALWTLALASAFMYIDRYAVNSWGIFFLeQDKAYSTLEASGIIGVNAIAG 294
Cdd:cd17355 189 RAYDDASPASPGSTLKE---------ALRSASFWLLALAFFLCGFAVVGLIVHLVPYL-ADRGISPAAAAVALALIGLFN 258
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490232023 295 IAGTIIAGMLSDRFFPRnrsVMAGFISLLNTAGFALMLWSPHGYYTDILAMIIFGATIGALTCFLGGLIAvDISSRKAAG 374
Cdd:cd17355 259 IVGRLLSGWLGDRYSPR---RLLAASYALRALGLALLLLLPFPPLALLLFAALFGLGWGATVPLTAALAA-RYFGARSYG 334
|
330 340
....*....|....*....|....*...
gi 490232023 375 AALGTIGIASYAGAGLGEFLTGIIIDKT 402
Cdd:cd17355 335 TLFGLVFAPHQLGSALGPWLGGLLYDRT 362
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
36-400 |
7.44e-20 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 90.95 E-value: 7.44e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490232023 36 MTLAYVTFYVCRLSFTVA-KSALVELGITPTELGMIGSTLFFSYAIGKLVNGFIADHANVVRYMSLGLLLSAGMNLMMGM 114
Cdd:cd06174 1 LLLGFFLTGLARGLISPLlPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490232023 115 TSNAMLLAIFWGINGWAQSMGVGPCVVSLARWYGCKERGTFYAIWSTAHNIGE--AMTYMVIAAVIAGFGWQMGYLSTAA 192
Cdd:cd06174 81 APSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGilGPLLGGILASSLGFGWRAVFLIAAA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490232023 193 LGAAGVVLMLLFMRDSPQSCGFPSinvirdepleETEARGSVFKNQLLALRNPALWTLALASAFMYIDRYAVNSWGIFFL 272
Cdd:cd06174 161 LALLAAILLLLVVPDPPESARAKN----------EEASSKSVLKLLKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFL 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490232023 273 EQDKAYSTLEASGIIGVNAIAGIAGTIIAGMLSDRFFPRNRSVMAGFISllntAGFALMLWSPHGYYTDILAMIIFGATI 352
Cdd:cd06174 231 LDLGGLSVAVAGLLLSLFGLAGALGSLLLGLLSDRLIGRKPLLLIGLLL----MALGLALLLLAPSLLLLLLLLLLLGFG 306
|
330 340 350 360
....*....|....*....|....*....|....*....|....*...
gi 490232023 353 GALTCFLGGLIAVDISSRKAAGAALGTIGIASYAGAGLGEFLTGIIID 400
Cdd:cd06174 307 LGGLLPLSFALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLA 354
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
57-404 |
1.49e-19 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 89.94 E-value: 1.49e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490232023 57 LVELGITPTELGMIGSTLFFSYAIGKLVNGFIADHANVVRYMSLGLLLSAGMNLMMGMTSNAMLLAIFWGINGWAQSMgV 136
Cdd:cd17325 23 AESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAFATSYWQLLLARFLQGLASAA-V 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490232023 137 GPCVVSL-ARWYGCKERGTFYAIWSTAHNIGeamtyMVIAAVIAGF-----GWQMGYLSTAALGAAGVVLMLLFMRDSpq 210
Cdd:cd17325 102 WPAAMALiADIAPPEERGRAMGIFSSAIGLG-----FLIGPLLGGLladalGYRAPFLVCAALALLALVLALLLLPEP-- 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490232023 211 scgfpsinviRDEPLEETEARGSVFKNQLLALRNPALWTLALASAFMYIDRYAVNSWGIFFLEQDKAYSTLEASGIIGVN 290
Cdd:cd17325 175 ----------RPPPNKRAVSAARLRSGLRLLLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQIGLLFGAQ 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490232023 291 AIAGIAGTIIAGMLSDRfFPRNRSVMAGFISllnTAGFALMLWSPHGYYTDILAMIIFGATIGALTCFLGGLIAvDISSR 370
Cdd:cd17325 245 GLASALSQPPAGKLSDR-IGRKPLILIGLLL---SAVALLLLPLATSFWLLLLLLALLGLGLGLVFPATLALLA-DIVPP 319
|
330 340 350
....*....|....*....|....*....|....
gi 490232023 371 KAAGAALGTIGIASYAGAGLGEFLTGIIIDKTSM 404
Cdd:cd17325 320 EGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAFGF 353
|
|
| MFS_SLC37A3 |
cd17342 |
Solute carrier family 37 member 3 of the Major Facilitator Superfamily of transporters; Solute ... |
67-401 |
1.04e-15 |
|
Solute carrier family 37 member 3 of the Major Facilitator Superfamily of transporters; Solute carrier family 37 member 3 (SLC37A3) is also called sugar phosphate exchanger 3 (SPX3), and is one of four SLC37 family proteins in vertebrates. It's function and activity is unknown. The best characterized SLC37 family member is SLC37A4, also called the glucose-6-phosphate transporter (G6PT), a phosphate (Pi)-linked G6P antiporter. SLC37A3 is a member of the Organophosphate:Pi antiporter (OPA)/SLC37 family, whose members are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340900 [Multi-domain] Cd Length: 399 Bit Score: 78.51 E-value: 1.04e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490232023 67 LGMIGSTLFFSYAIGKLVNGFIADHANVVRYMSLGLLLSAGMNLMMGMTS------NAMLLAIFWGINGWAQSMGvGPCV 140
Cdd:cd17342 65 LGVLDTIFLFSYAIGLFISGWLGDRLNLRLVLAFGMCSSAITVFLFGVLTewlhfyNKYLYCILWVLNGLLQSTG-WPCV 143
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490232023 141 VSL-ARWYGCKERGTFYAIWSTAHNIGEAMTYMVIAAVIAgFGWQMGYLSTAALGAAGVVLMLLFMRDSPqscgfpsinv 219
Cdd:cd17342 144 VAImGNWFGKSSRGFVLGLWSACASVGNIIGALLASSVLD-YGYEYAFLVTSSLLFAGAIVVFFGLLSSP---------- 212
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490232023 220 irdepleeteargsvfknqllalrnPALWTLALASAFMYIDRYAVNSWGIFFLEQDKAYSTLEASGIIGVNAIAGIAGTI 299
Cdd:cd17342 213 -------------------------PGVIPYSLAYACLKLVNYSFFFWLPFYLSNNFHWKESEADQLSIWYDVGGIIGGI 267
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490232023 300 IAGMLSDRFFPRNRSVmagFISLLNTAGfALMLWS--PHGYYTDILAMIIFGATIGALTCFLGGLIAVDISSRKA---AG 374
Cdd:cd17342 268 VAGYISDRMGSRSPVV---VVMLLLAIP-SLFVYShsPSDKVLNAFVMTITGFFIGGPANLISSAISADLGRQPQlrgSS 343
|
330 340 350
....*....|....*....|....*....|..
gi 490232023 375 AALGTI-----GIASyAGAGLGEFLTGIIIDK 401
Cdd:cd17342 344 EALATVtgiidGTGS-IGAAIGQVLVPLIQNR 374
|
|
| MFS_SLC37A1_2 |
cd17344 |
Solute carrier family 37 members 1 and 2 of the Major Facilitator Superfamily of transporters; ... |
67-398 |
1.82e-15 |
|
Solute carrier family 37 members 1 and 2 of the Major Facilitator Superfamily of transporters; Solute carrier family 37 members 1 (SLC37A1) and 2 (SLC37A2) are also called sugar phosphate exchangers 1 (SPX1) and 2 (SPX2). SLC37A1 and SLC37A2 are ER-associated, Pi-linked antiporters that can transport glucose-6-phosphate (G6P) but are insensitive to chlorogenic acid, a competitive inhibitor of physiological ER G6P transport, unlike SLC37A4, the best characterized SLC37 family member and is the physiological G6P transporter (G6PT). SLC37A1 and SLC37A2 belong to the Organophosphate:Pi antiporter (OPA)/SLC37 family, whose members are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340902 [Multi-domain] Cd Length: 400 Bit Score: 77.74 E-value: 1.82e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490232023 67 LGMIGSTLFFSYAIGKLVNGFIADHANVVRYMSLGLLLSAGMNLMMGMtsnamllAIFWGI------------NGWAQSM 134
Cdd:cd17344 64 LGALDSAFLFAYAIGMFFSGHIGERLPLRYFLSFGMLLSGLFTALFGL-------GYYWNIhslwyfvvvqilAGLFQST 136
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490232023 135 GvGPCVVS-LARWYGCKERGTFYAIWSTAHNIGEaMTYMVIAAVIAGFGWQMGYLSTAALGAAGVVLMLLFMRDSPqscg 213
Cdd:cd17344 137 G-WPSVVAcVGNWFGKGKRGLIMGIWNSHTSVGN-ILGSLIAGIFVSSAWGLSFIVPGIIIAAMGVLVFLFLVEHP---- 210
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490232023 214 fpsinvirdepleeteargsvfknqllalrnPALWTLALASAFMYIDRYAVNSWGIFFLEQDKAYSTLEASGIIGVNAIA 293
Cdd:cd17344 211 -------------------------------PGVIEFSLCLFFAKLVSYTFLYWLPLYISNTAILSAKKAGDLSTLFDVG 259
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490232023 294 GIAGTIIAGMLSDRFFPRNrSVMAGFISLLNTAGFALMLWSPHGYYTDILAMIIFGATIGALTCFLGGLIAVDI---SSR 370
Cdd:cd17344 260 GIVGGILAGYISDYTGGRA-TTCAAMLILAAPMLFIYNYFGQVSMTTNIVLLIVCGLLVNGPYALITTAVSADLgthKSL 338
|
330 340 350
....*....|....*....|....*....|...
gi 490232023 371 KAAGAALGTI-----GIASyAGAGLGEFLTGII 398
Cdd:cd17344 339 KGNARALATVtaiidGTGS-IGAALGPLLAGLI 370
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
59-404 |
3.41e-15 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 76.83 E-value: 3.41e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490232023 59 ELGITPTELGMIGSTLFFSYAIGKLVNGFIADHANVVRYMSLGLLLSAGMNLMMGMTSNAMLLAIFWGINGWAQSMgVGP 138
Cdd:cd17478 25 KLGLSYAQAGLLVSVFSITSSLLQPLFGYLADRKPRRYLLPLGPLLTGLGLSLLGFAPNYWLLLLLVALAGIGSAA-FHP 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490232023 139 CVVSLARWYGCKERGTFYAIWSTAHNIGEAMTYMVIAAVIAGFGwQMGYLSTAALGAAGVVLMLLFMRDSPqscgfPSIN 218
Cdd:cd17478 104 EGARLASQAAGGRRGLAMSIFSVGGNLGFALGPLIAAALVALFG-GLGLLILLIIPGLAVALLLLRLRPLK-----KPEA 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490232023 219 VIRDEPLEETEARGSVFKNQLLalrnpaLWTLALASAFMYidrYAVNSWGIFFLEQdKAYSTLEASGIIGVNAIAGIAGT 298
Cdd:cd17478 178 KKAAAKSSARSTLKGVWRALLL------LLIIVFLRSWVL---SSLTTFLPFYLVQ-RGYSLVFAGLLLSLFLFAGAIGT 247
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490232023 299 IIAGMLSDRFfpRNRSVMagFISLLNTAGFALMLWSPHGYYTDILAMIIFGATIGALTcfLGGLIAVDISSRKAAGAALG 378
Cdd:cd17478 248 LIGGPLSDRF--GRRRVI--IASLLLAAPFLLLFLLTPGIWSYILLVLAGFLLFASFP--VTVVLAQELLPGNVGLASGL 321
|
330 340
....*....|....*....|....*.
gi 490232023 379 TIGIaSYAGAGLGEFLTGIIIDKTSM 404
Cdd:cd17478 322 MMGL-SFGLGGIGAPVLGALADAFGL 346
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
59-404 |
1.05e-14 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 75.28 E-value: 1.05e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490232023 59 ELGITPTELGMIGSTLFFSYAIGKLVNGFIADHANVVRYMSLGLLLSAGMNLMMGMTSNAMLLAIFWGINGWAQSMGVGP 138
Cdd:cd17324 28 DFGVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALAPSFALLLLARALAGLAHGGFWAI 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490232023 139 CVVSLARWYGCKERGTFYAIWSTAHNIGeamtyMVIAAVIAGF-----GWQMGYLSTAALGAAGVVLMLLFMRDSPqscg 213
Cdd:cd17324 108 AAAYAADLVPPEKRGRAIGLVFSGLTLG-----LVLGRPLGGLlgqllGWRAAFLAIAVLALLAALLLWRLLPSLP---- 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490232023 214 fpsinvirdeplEETEARGSVFKNQLLALRNPALWTLALASAFMYIDRYAVNSWGIFFLEQDKAYSTLEASGIIGVNAIA 293
Cdd:cd17324 179 ------------PKKPGSLGLLSSLLLLLRNPRLRLAYLITFLLFGGFFALYTYLAPFLTDVPGFSSSAIIGLLLLFGVA 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490232023 294 GIAGTIIAGMLSDRFFPRNRSVMAGFISLlntAGFALMLWSPHGYYTdILAMIIFGATIGAltCFLGGLIAVDISSRKAA 373
Cdd:cd17324 247 GVVGSPLAGRLADRGGRRALLIALLLLAA---ALLLLTLLGPSPLLL-LVGLVLWGLGFFA--AHSALQTRVLRLAPEAR 320
|
330 340 350
....*....|....*....|....*....|.
gi 490232023 374 GAALGTIGIASYAGAGLGEFLTGIIIDKTSM 404
Cdd:cd17324 321 GLASSLYLAAYNLGGALGAALGGLVLDHGGW 351
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
59-404 |
2.50e-12 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 67.96 E-value: 2.50e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490232023 59 ELGITPTELGMIGSTLFFSYAIGKLVNGFIADHANVVRYMSLGLLLSAGMNLMMGMTSNAMLLAIFWGINGWAQSM---G 135
Cdd:COG0738 37 AFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMALGLLLFALAPSYPLLLLALFLLGLGLGLldvA 116
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490232023 136 VGPCVVSLARWYGCKERGTFYAIWSTAHNIGEAMTYMVIAAVIaGFGWQMGYLstaALGAAGVVLMLLFMRdspqscgfp 215
Cdd:COG0738 117 ANPYVAALGPETAASRLNLLHAFFSLGALLGPLLGGLLILLGL-SLSWHLPYL---ILAVLLLLLALLFLR--------- 183
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490232023 216 sinVIRDEPLEETEARGSVFKNQLLALRNPALWTLALASAFMYIDRYAVNSWGIFFLEQDKAYSTLEASGIIGVNAIAGI 295
Cdd:COG0738 184 ---SKLPEIEEEEEEAAGSAASLKSLLKNPRLLLGGLAIFLYVGAEGAIGDWLPLYLKDVLGLSEATAALGLSLFWGGMT 260
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490232023 296 AGTIIAGMLSDRFfprNRSVMAGFISLLNTAGFALMLWSPHGYYTdILAMIIFGATIGALtcFLGGLIAVDISSRKAAGA 375
Cdd:COG0738 261 IGRFLGGFLLKRF---GPVRLLRLSALLAAVGLLLALLAPGPWLA-LIGLALVGLGLSLM--FPTIFSLALDGLGKRTAA 334
|
330 340
....*....|....*....|....*....
gi 490232023 376 ALGTIGIASYAGAGLGEFLTGIIIDKTSM 404
Cdd:COG0738 335 AVSAVLIMGIVGGAIGPPLIGFLADAFGL 363
|
|
| MFS_spinster_like |
cd17328 |
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ... |
52-364 |
1.25e-11 |
|
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340886 [Multi-domain] Cd Length: 405 Bit Score: 66.11 E-value: 1.25e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490232023 52 VAKSALVELGITPTELGMIGSTLFFSYAIGKLVNGFIADHANVVRYMSLGLLLSAGMNLMMGMTSNAMLLAIFWGINGWA 131
Cdd:cd17328 21 VLPDIQSDFLIDDSLAGLLQTVFIISYMVLSPIFGYLGDRYNRKWILAVGILIWSAATLLSSFAPNFWQLLLFRALVGIG 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490232023 132 QSmGVGPCVVSL-ARWYGCKERGTFYAIWSTAHNIGEAMTYMVIAAVI-AGFGWQMGYLSTAALGAAGVVLMLLFMRDSP 209
Cdd:cd17328 101 EA-SYSPIAPTIiADLFPKEKRTRALGVFYFAIPLGSGLGYVVGGLVAqATGGWRWAFRVTGVLGVLLAILLLLFVREPP 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490232023 210 QScgfpsinvIRDEPLEETEARGSVFKNQLLALRNPALWTLALASAFMYIDRYAVNSWGIFFL---EQDKAYSTLEASGI 286
Cdd:cd17328 180 RG--------AAEGGVMAKSTATSFLADLKALAKNPSFILSTLGFTAVSFVTGALAFWAPTFFlraFGVGDLSSADVGLI 251
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490232023 287 IG-VNAIAGIAGTIIAGMLSDRFFPRNRS--VMAGFISLLNTAGFALMlwSPHGYYTDILAMIIFGATIGALTCFLGGLI 363
Cdd:cd17328 252 FGaITCIAGVLGVLLGGILADRLRRKTPRadPLVCAVGLLAAAPFLFL--ALVLALSNLLLAWVLLFLGEFLLSLNWAPV 329
|
.
gi 490232023 364 A 364
Cdd:cd17328 330 F 330
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
59-399 |
1.26e-11 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 65.84 E-value: 1.26e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490232023 59 ELGITPTELGMIGSTLFFSYAIGKLVNGFIADHANVVRYMSLGLLLSAGMNLMMGMTSNAMLLAIFWGINGWAQSMGVGP 138
Cdd:TIGR00895 46 EWGLDPVQLGFLFSAGLIGMAFGALFFGPLADRIGRRRVLLWSILLFSVFTLLCALATNVTQLLILRFLAGLGLGGLMPN 125
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490232023 139 CVVSLARWYGCKERGTFYAIWSTAHNIGEAMTYMVIAAVIAGFGWQMGYLSTaalGAAGVVLMLLFMRDSPQSCGF---- 214
Cdd:TIGR00895 126 LNALVSEYAPKRFRGTAVGLMFCGYPIGAAVGGFLAGWLIPVFGWRSLFYVG---GIAPLLLLLLLMRFLPESIDFlvsk 202
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490232023 215 -------------PSINVIRDEPLEETEARGSVFKNQLLAL-------RNPALWTLALASAFMYidrYAVNSWgIFFLEQ 274
Cdd:TIGR00895 203 rpetvrrivnaiaPQMQAEAQSALPEQKSTQGTKRSVFKALfqgktarITVLLWLLYFMLLVGV---YFLTNW-LPKLMV 278
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490232023 275 DKAYSTLEASGIIGVNAIAGIAGTIIAGMLSDRFfprNRSVMAGFisLLNTAGFALMLWSPHGYYTDILAMI-IFGATIG 353
Cdd:TIGR00895 279 ELGFSLSLAATGGALFNFGGVIGSIIFGWLADRL---GPRVTALL--LLLGAVFAVLVGSTLFSPTLLLLLGaIAGFFVN 353
|
330 340 350 360
....*....|....*....|....*....|....*....|....*.
gi 490232023 354 ALTCFLGGLIAVDISSRKAAGAALGTIGIASyAGAGLGEFLTGIII 399
Cdd:TIGR00895 354 GGQSGLYALMALFYPTAIRATGVGWAIGIGR-LGAIIGPILAGYLL 398
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
59-398 |
1.48e-11 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 65.67 E-value: 1.48e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490232023 59 ELGITPTELGMIGSTLFFSYAIGKLVNGFIADHANVVRYMSLGLLLSAGMNLMMGMTSNAMLLAIFWGINGWAQSMGVGP 138
Cdd:cd17474 28 ALGASPAQVGLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGGLLCGLSDSFALLLAGRALQGIGAAGLGPL 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490232023 139 CVVSLARWYGCKERGTFYAIWSTAHNIGEAmTYMVIAAVIAGFGWQMGYLSTAALGAAGVVLMLLFmrdspqscgfpsin 218
Cdd:cd17474 108 ALTLIGDLFEGGERAKAMGLYEAALGLGIA-VGPLLGGLLAAISWRYPFFLLAALIPVAFLAILFL-------------- 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490232023 219 vIRDEPLEETEARGSVFKNQLLALRNPALWTLALASAFMYIDRYAVNSWGIFFLEQDKAYSTLEASGIIGVNAIAGIAGT 298
Cdd:cd17474 173 -LPEPKEKAKSSSATKLRDLKKALRGRGLLTFLVSAFLYFFLYFAFLTYLPFLLELLYGISPIIIGLLFAGWSVLLALGS 251
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490232023 299 IIAGMLSDRFFPRNRSVMAGFisLLNTAGFALMLWSpHGYYTDILAMIIFGATIGALTCFLGGLIAvDISSRKAAGAALG 378
Cdd:cd17474 252 LFVGRLLKKRFGARRILVIGL--LLYALSLLLLGFV-PSLALLLIAIVLFGLGLGLNLPLLTTLVT-ELAPEEERGTASS 327
|
330 340
....*....|....*....|
gi 490232023 379 TIGIASYAGAGLGEFLTGII 398
Cdd:cd17474 328 LYNFVRFLGQAVGPLLFGLL 347
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
150-441 |
7.84e-11 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 63.77 E-value: 7.84e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490232023 150 KERGTFYAIWSTAHNIGEAMTYMVIAAVIAGF------GWQMGYLSTAALGAAGVVLMLLFMRdspqscgfpsinvirdE 223
Cdd:COG2211 143 EERTRLSSWRFAFAGLGGLLASVLPPPLVAAFggdaalGYRLTALIFAVLGLLAFLLTFFGTK----------------E 206
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490232023 224 PLEETEARGSVFKNQLLALRNPALWTLALASAFMYIDRYAVNSWGIFFLEQDKAYSTLEASGIIGVNAIAGIAGTIIAGM 303
Cdd:COG2211 207 RPVPEEEKVSLKESLKALLKNRPFLLLLLAYLLFFLALALVAALLLYYFKYVLGLSAALVGLLLALYFLAALLGAPLWPR 286
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490232023 304 LSDRFFPRNRSVMAGFISLLntAGFALMLWSPHGYYTDILAMIIFGATIGALTCFLGGLIA--VD----ISSRKAAGAAL 377
Cdd:COG2211 287 LAKRFGKKKAFIIGLLLAAL--GLLLLFFLGPGNLWLLLVLAALAGIGLGAILVLPWAMLAdvVDydewKTGRRREGLYF 364
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 490232023 378 GTIGIASYAGAGLGEFLTGIIIDKTSMIENGKTlyDFSTLSLFWVGTGLMSALFCFTTAAIVAR 441
Cdd:COG2211 365 GIFTFAIKLGQALAGALAGLLLALFGYVAGAAQ--SPSALTGIRLLFFLLPAVLLLLAALLLLF 426
|
|
| MFS_NRT2_like |
cd17341 |
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major ... |
59-398 |
3.42e-10 |
|
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major Facilitator Superfamily; This family is composed of plant NRT2 family high-affinity nitrate transporters as well as nitrate and nitrite transporters from bacteria including Bacillus subtilis nitrate transporter NasA and nitrite extrusion protein NarK, Staphylococcus aureus NarT, Synechococcus sp. nitrate permease NapA, Mycobacterium tuberculosis NarK2 and nitrite extrusion protein NarU. NRT2 family proteins are involved in the uptake of nitrate by plant roots from the soil through the high-affinity transport system (HATS). There are seven Arabidopsis thaliana NRT2 proteins, called AtNRT2:1 to AtNRT2:7. The NRT2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340899 [Multi-domain] Cd Length: 384 Bit Score: 61.50 E-value: 3.42e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490232023 59 ELGITPTELGMIGSTLFFSYAIGKLVNGFIADHANVVRYMSLGLLLSAGMNLMMG--MTSNAMLLAI--FWGINGWAQSm 134
Cdd:cd17341 28 DLGLSTSQIGLLVAIPVLAGALLRLPYGFLCDRFGGRRVFIASLLLLLIPLLALAlaVSSYWGLLVLgfLLGFAGANFA- 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490232023 135 gvgPCVVSLARWYGCKERGTFYAIWSTAHNIGEAMTYMVIAAVIA-------GFGWQMGYLSTAALGAAGVVLMLLFMRD 207
Cdd:cd17341 107 ---SGQPWASFWFPKEKIGGAAGGIAGAGNMGVAVSQLLAPLIAGaivfdggFVGWRNAFFVPGILLAIAAVLVLLFGDD 183
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490232023 208 SPQScgfpsinvirdepleeTEARGSVFKNQLLALRNPALWTLALASAFMYIDRYAVNSWGIFFLEQDKAYSTLEASGII 287
Cdd:cd17341 184 LPTG----------------KASALEFLKVQLAVLKNYRTWILSLLYGVTFGSFVGFSNVLPTYFKTRFGLPLVTAGILA 247
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490232023 288 GVNAIAGIAGTIIAGMLSDRFFPRnRSVMAGFIslLNTAGFALMLWSPHGYYTD----ILAMIIFGATIGALTCFLGGLI 363
Cdd:cd17341 248 ALFPLAGALARPAGGWLSDRFGGR-RRLWWLFI--VMTIGAALLSLSLPTSGTNlvlfLALFVALGLGAGAGNGSVFRMV 324
|
330 340 350
....*....|....*....|....*....|....*
gi 490232023 364 AVDisSRKAAGAALGTIGiasyAGAGLGEFLTGII 398
Cdd:cd17341 325 PFI--FRRELGAVTGLVG----AIGGLGGFFLPLL 353
|
|
| MFS_PcaK_like |
cd17365 |
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ... |
51-353 |
3.91e-08 |
|
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340923 [Multi-domain] Cd Length: 351 Bit Score: 54.90 E-value: 3.91e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490232023 51 TVAKSALVELGITPTELGMIGSTLFFSYAIGKLVNGFIADHANVVRYMSLGLLLSAGMNLMMGMTSNAMLLAIFWGINGw 130
Cdd:cd17365 20 FVAPALAQDWGLSPAQLGPVGSAALFGMAIGALLAGPLADRFGRKRVLLVSVALFGLFTLLTAFAQSVLQLALLRFLTG- 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490232023 131 aqsMGVG---PCVVSLARWY-GCKERGTFYAIWSTAHNIGEAMTYMVIAAVIAGFGWQmgylSTAALGAAGVVLMLLFMR 206
Cdd:cd17365 99 ---LGLGaamPNAITLVSEYaPARRRSLAVTLMFCGYPLGAALGGFLAAALIPAFGWR----SVFLLGGVPPLILLPLLR 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490232023 207 DSPqscgfpsinvirdepleeteargsvfknqllalrnpALWTLALASAFMYidrYAVNSWgIFFLEQDKAYSTLEASGI 286
Cdd:cd17365 172 GTL------------------------------------LLWVTFFMGLLLV---YLLNSW-LPKLMVEAGYSLSQALTI 211
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 490232023 287 IGVNAIAGIAGTIIAGMLSDRFFPRNRSVMAGFISLLNTAGFALMLWSPHGYYTDILA--MIIFGATIG 353
Cdd:cd17365 212 TLLLNIGGVIGSLLLGWLADRFGPKRVLALFFALGAVSLALLGVSPASLVLLYVLVFLagACVNGAQVG 280
|
|
| MFS_MdfA_MDR_like |
cd17320 |
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ... |
59-402 |
7.86e-08 |
|
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340878 [Multi-domain] Cd Length: 379 Bit Score: 54.12 E-value: 7.86e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490232023 59 ELGITPTELGMIGSTLFFSYAIGKLVNGFIADHANVVRYMSLGLLLSAGMNLMMGMTSNAMLLAIFWGIngwaQSMGVGP 138
Cdd:cd17320 28 DLGASASAVQLTLSAYLLGFALGQLLYGPLSDRFGRRPVLLAGLLLFILASLLCALASSIEQLLIARFL----QGLGAAA 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490232023 139 CVV---SLAR-WYGCKERGTFYAIWSTAHNIGEAMTYMVIAAVIAGFGWQMGYLSTAALGAAGVVLMLLFMRDSPQscgf 214
Cdd:cd17320 104 GSVvarAIVRdLYSGAELAKIFSLLMMILAIAPALAPLLGGLLLLFFGWRAIFVFLALLGLLLLLLVLLFLPETLP---- 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490232023 215 psinvirdePLEETEARGSVFKNQLLALRNPALWTLALASAFMYIDRYAVNSWGIFFLEQDKAYSTLEASGIIGVNAIAG 294
Cdd:cd17320 180 ---------EEKRKPLLSSLLRAYKRVLKNRRFLGYALALGLSFAGLFAYLAAAPFIYIEQLGLSPAQFGLLFALNAIAL 250
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490232023 295 IAGTIIAGMLSDRFFPRNRSVMAGFISLLNTAGFALM-LWSPHGYYTDILAMIIFGATIGAL--TCFLGGLIAVDissrK 371
Cdd:cd17320 251 ILGSLLNGRLVRRFGPRRLLRLGLLLLLAAALVLLLAaLLGGLSLWPLVAPLFLIFFGFGLIfpNATSLALEPFP----H 326
|
330 340 350
....*....|....*....|....*....|.
gi 490232023 372 AAGAALGTIGIASYAGAGLGEFLTGIIIDKT 402
Cdd:cd17320 327 VAGTASALLGFLQFLIGALAGALVGLLPNGT 357
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
32-210 |
9.16e-08 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 53.72 E-value: 9.16e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490232023 32 TFITMTLAYVTFYVCRLSFTV-AKSALVE-LGITPTELGMIGSTLFFSYAIGKLVNGFIADH--ANVVRYMSLGLLLSAG 107
Cdd:COG2271 181 RFWLLALAYFLVYFALYGFLTwLPTYLVEvRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRlgRRRKLVLAIGLLLAAL 260
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490232023 108 MNLMMGMTSNAMLLAIFWGINGWAQSMGVGPCVVSLARWYGCKERGTFYAIWSTAHNIGEAMTYMVIAAVIAGFGWQMGY 187
Cdd:COG2271 261 ALLLLALLPSPALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATGYQAAF 340
|
170 180
....*....|....*....|...
gi 490232023 188 LSTAALGAAGVVLMLLFMRDSPQ 210
Cdd:COG2271 341 LLLAALALLAALLALLLLRETRK 363
|
|
| MFS_MucK |
cd17371 |
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ... |
51-403 |
1.69e-07 |
|
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340929 [Multi-domain] Cd Length: 389 Bit Score: 53.07 E-value: 1.69e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490232023 51 TVAKSALVELGITPTELGMIGSTLFFSYAIGKLVNGFIADHANVVRYMSLGLLLSAGMNLMMGMTSNAMLLAIFWGIngw 130
Cdd:cd17371 20 LVLPALIAEFGLDEAEAGLLGTVTLAGGAIGGILGGILADRFGRVRVLVITILLFAVFTLLCGFAQNYWQLLILRAL--- 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490232023 131 aQSMGVG----PCVVSLARWYGCKERGTFYAIWSTAHNIG----EAMTYMVIAAVIAGFGWQMGYLsTAALGAAGVVLML 202
Cdd:cd17371 97 -AGLGFGgewaAGAALMAEYVPARHRGKALGYVQSGWAVGwllaTLLAALLFPLLPPEIAWRVLFL-LGALPALLVLFIR 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490232023 203 LFMRDSPQScgfpsinVIRDEPLEETEARGSVFKNQLLALRNPALWTlALASAFMYIDRYAVNSWGIFFLEQDKAYSTLE 282
Cdd:cd17371 175 RFVKEPPQW-------QAARAARRHFADRPSLRELFSPPLLRTTLLA-SLLATGALGGYYGITTWLPSYLTGERGLSFEG 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490232023 283 ASGIIGVNAIAGIAGTIIAGMLSDRFfprNRSVMAGFISLLNTAGFALMLWSPHGYYTDILAMIIFGATIGALTCFLGGL 362
Cdd:cd17371 247 SAGYLVVTILGGFLGYLAGGFLADRI---GRRNNFALFALGSAISILLYFFLPLSPTLILILGFPLGFFASGPFSGMGAY 323
|
330 340 350 360
....*....|....*....|....*....|....*....|.
gi 490232023 363 IAVDISSRkAAGAALGTIGIASYAGAGLGEFLTGIIIDKTS 403
Cdd:cd17371 324 LTELFPTA-VRATAQGFCYNVGRIIGALFPFLVGFLATSGS 363
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
83-400 |
6.20e-07 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 51.46 E-value: 6.20e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490232023 83 LVNGFIADHANVVRYMSLGLLLSAGMNLMMGMTSNAMLLAIFWGINGWAQSMGVGPCVVSLARWYGCKERGTFYAIWSTA 162
Cdd:cd17329 53 LIGGRLADRFGRKPVMLAGLLLRALGFALLGFAHSPWLFAIALVLTGFGGGLFEPASEAMIADVTTPENRTRAFSLLYWA 132
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490232023 163 HNIGeamtyMVIAAVIAGFGWQMGYLSTAALGAAGVVLMLLFMrdspqscgfpSINVIRDEPLEETEARGSVFKNQLLAL 242
Cdd:cd17329 133 INLG-----VAIGPLLGGLLLLYSFRLLFLAAAVLFLLAALVL----------LFLLPETRPKRRAAEKTEILRGYKIVL 197
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490232023 243 RNPALWTLALASAFMYidrYAVNSWGIF---FLEQDKAYSTLEASGIIGVNAIAGIAGTIIAGMLSDRFFPRnRSVMAGF 319
Cdd:cd17329 198 RDRAFLLFLLASFLIS---LIYFQLESTlpvYVVEILGLGESLLGLLLALNALLIVLLQFPVARLVERFRLR-KILMIGI 273
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490232023 320 IslLNTAGFALMLWSPHgYYTDILAMIIFgaTIGALTCFLG-GLIAVDISSRKAAGAALGTIGIASYAGAGLGEFLTGII 398
Cdd:cd17329 274 L--LFAIGFAVLAFANT-LAVLILAMIVL--TLGEMLVFPAvQTLVAALAPPDKRGSYMGFYALAWGLGRAIGPLVGGLL 348
|
..
gi 490232023 399 ID 400
Cdd:cd17329 349 LD 350
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
59-391 |
1.66e-06 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 49.86 E-value: 1.66e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490232023 59 ELGITPTELGMIGSTLFFSYAIGKLVNGFIADHANVVRYMSLGLLLSAGMNLMMGMTSNAMLLAIFWGINGWAQSMgVGP 138
Cdd:cd17321 25 DLGASPSQLQWVVNAYLLAFAALLLLAGRLGDRFGRKRVFLIGLALFGLASLLCALAPSLAFLIAARALQGIGAAA-IMP 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490232023 139 CVVSL-ARWYGCKERGTFYAIWSTAHNIGEAMTYMVIAAVIAGFGWQMGYLSTAALGAAGVVLMLLFmrdspqscgfpsi 217
Cdd:cd17321 104 ASLALiAATFPGERRGRALGLWGAVVGIGAALGPLLGGLLLELFGWRWIFLINVPIGLVALLLARTF------------- 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490232023 218 nvirdepleeteargsvfknqllalrnpalWTLALASAFMYIDRYAVNSWGIFFLEQDKAYSTLEASGIIGVNAIAGIAG 297
Cdd:cd17321 171 ------------------------------SGAVLAAFLLGAALGGLLFLLPLYLQGVLGYSPLQAGLALLPLALAMLVA 220
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490232023 298 TIIAGMLSDRFFPRnrsVMAGFISLLNTAGFALMLWSPH--GYYTDILAMIIFGATIGaltCFLGGLIAVDISS--RKAA 373
Cdd:cd17321 221 APLAGRLADRFGPR---LVLVAGLLLTAVGLLLLALLGAdsSVWLLLPGLVLLGLGLG---LFATPLTNAALSSvpKEKA 294
|
330
....*....|....*...
gi 490232023 374 GAALGTIGIASYAGAGLG 391
Cdd:cd17321 295 GAASGILNTARQLGGALG 312
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
60-400 |
2.48e-06 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 49.49 E-value: 2.48e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490232023 60 LGITPTELGMIGSTLFFSYAIGKLVNGFIADHANVVRYMSLGLLLSAGMNLMMGMTSNAMLLAIFWGINGWAQSmGVGPC 139
Cdd:cd17473 30 VPNSELLVPLLLTLPALFIALFAPLAGWLADRFGRKRLLIAGLLLYGIGGVAGLFLDSLYALLASRALLGIGVA-GIMTL 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490232023 140 VVSL-ARWYGCKERGTFYAIWSTAHNIGeAMTYMVIAAVIAGFGWQMGYLstaaLGAAGVVLMLLFMRDSPqscgfpsin 218
Cdd:cd17473 109 ATALiGDYFEGEERAKMLGLQSAAMSLG-GVVFLLLGGALAEIGWRAPFL----VYLLALPVLILVLLFLP--------- 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490232023 219 virdEPLEETEARGSVFKNQLLALRNPALWTLALASAFMYIDRYAVNSWGIFFLEQDKAYSTLEASGIIGVNAIAGIAGT 298
Cdd:cd17473 175 ----EPARKSKSAASPGAATAAALPWKRVLPIYFLAFLAMLLFYVIPIQLPFLLQERGGGSAALIGLALAIASLAGAIGA 250
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490232023 299 IIAGMLSDRFFPRnRSVMAGFISLlnTAGFALMLWSPhGYYTDILAMIIFGATIGALTCFLgGLIAVDISSRKAAGAALG 378
Cdd:cd17473 251 LLFGRLKRRLGKR-RLLAIGFALM--ALGFLLLALAS-GLWVVLLGAILAGLGFGLLLPTL-NSWAMSLVPPELRGRAMG 325
|
330 340
....*....|....*....|..
gi 490232023 379 TIGIASYagagLGEFLTGIIID 400
Cdd:cd17473 326 IVTSAFF----LGQFLSPLVLG 343
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
55-354 |
2.71e-06 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 49.14 E-value: 2.71e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490232023 55 SALVELGITPTELGMIGSTLFFSYAIGKLVNGFIADHANVVRYMSLGLLLSAGMNLMMGMTSNAMLLAIFWGINGWAQSM 134
Cdd:cd17316 26 AAEFSLGLSLLQTGLLFAAGFLGRPIGALLFGYLGDRIGRKKALILTLLLFGLATLLIGLLPTPILLLVLRFLQGIGIGG 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490232023 135 GVGPCVVSLARWYGCKERGTFYAIWSTAHNIGEAMTYMVIAAVI----AGFGWQMGYLSTAALGaagvvLMLLFMRdspq 210
Cdd:cd17316 106 EYPGASTYVAEFAPSKRRGFALGLLQSGWALGALLAALVASLLIpllsGDWGWRILFLIGALPA-----LLALLLR---- 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490232023 211 scgfpsinvirdepleeteargsvfknqllalrnPALWTLALASAFMYIDRYAVNSWGIFFLEQDKAYSTLEASGIIGVN 290
Cdd:cd17316 177 ----------------------------------RRTLLLILLWFFISFGYYGLTTFLPTYLQTVLGLSPATSSLYLLLI 222
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 490232023 291 AIAGIAGTIIAGMLSDRFFPRNRSVMAGFISLLntAGFALMLWSPHGYYTDILAMIIFGATIGA 354
Cdd:cd17316 223 SLGALVGALIAGLLSDRIGRKKTLVIGLILSGI--LALPLFYLLSGSPTLLLLLLFILSFFVGG 284
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
29-204 |
3.57e-06 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 48.65 E-value: 3.57e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490232023 29 RWQTFITMTLAYVTFYVCRLSFTVAKSALV-ELGITPTELGMIGSTLFFSYAIGKLVNGFIADHANVVRYMSLGLLLSAG 107
Cdd:COG0477 12 RRRALLALALGTFLEGLDFTIVNVALPSIAaDLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFGL 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490232023 108 MNLMMGMTSNAMLLAIFWGINGWAQSMGVGPCVVSLARWYGCKERGTFYAIWSTAHNIGEAMTYMVIAAVIAGFGWQMGY 187
Cdd:COG0477 92 ASLLCGLAPSPELLIAARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLVAALGWRWIF 171
|
170
....*....|....*..
gi 490232023 188 LSTAALGAAGVVLMLLF 204
Cdd:COG0477 172 LINAPLGLLALVLRLRL 188
|
|
| MFS_OFA_like |
cd17353 |
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ... |
49-354 |
3.62e-06 |
|
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340911 [Multi-domain] Cd Length: 389 Bit Score: 48.76 E-value: 3.62e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490232023 49 SFTVAKSALVE-LGITPTELGMIGSTLFFSYAIGKLVNGFIADHANVVRYMSLGLLLSAGMNLMMGMTSNAMLLAI-FWG 126
Cdd:cd17353 21 AWSVFNPPLSSaLGWSLASVALAFTLTIVFLAISAPFAGRLVDRGGPRKAILIGGILFGLGFILSAFAISLPLLFLgYGV 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490232023 127 INGWAQSMGVGPCVVSLARWYGCKeRGTFYAIWSTAHNIGEAMTYMVIAAVIAGFGWQMGYLSTAALGAAGVVLMLLFMR 206
Cdd:cd17353 101 LGGIGAGIGYITPVSTAVKWFPDK-RGLATGIVIAGFGLGSLIFSPLIAYLINTVGVPTTFLILGIIFLIIIVIGAFLIR 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490232023 207 DSPQSCGFPSINvirdePLEETEARGSVFKNQLLALRNPALWTLALASAFMyidryavNSWGIF-------FLEQDKAYS 279
Cdd:cd17353 180 DPPKGWVPPGVD-----PLANNAENSPRDYTPREMLRTPTFWLLWLMFFLN-------ATAGLMligqakpIGQEFAGLD 247
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 490232023 280 TLEASGIIGVNAIAGIAGTIIAGMLSDRfFPRNRSVMAGFisLLNTAGFALMLWSPHGYYTDILAMIIFGATIGA 354
Cdd:cd17353 248 AGIAALAVSILSIFNGGGRPFWGWLSDK-IGRKNTLSIAF--LIQGVAMFLLPFIGSVAVLFVLGVALIGFCYGG 319
|
|
| MFS_SLC17A9_like |
cd17380 |
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of ... |
34-403 |
4.27e-06 |
|
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily includes solute carrier family 17 member 9 (SLC17A9) and similar proteins including plant inorganic phosphate transporters (PHT4) that are also probably anion transporters. SLC17A9, also called vesicular nucleotide transporter (VNUT), is involved in vesicular storage and exocytosis of ATP. It facilitates the accumulation of ATP and other nucleotides in secretory vesicles such as adrenal chromaffin granules and synaptic vesicles. It also functions as a lysosomal ATP transporter and regulates cell viability. Plant PHT4 family transporters mediate the transport of inorganic phosphate and may also transport organic anions. The Arabidopsis protein AtPHT4;4 is a chloroplast-localized ascorbate transporter. PHT4 proteins show differential expression that suggests specialized functions. The SLC17A9-like subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340938 [Multi-domain] Cd Length: 361 Bit Score: 48.70 E-value: 4.27e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490232023 34 ITMTLAYVTFYVCRLSFTVAKSALV-ELGITPTELGMIGSTLFFSYAIGKLVNGFIADHANVVRYMSLGLLLSAGMNLMM 112
Cdd:cd17380 2 ILLFLATCICYADRVNMPIAIVPMAkEFGWSKTDQGLVLSSFFWGYALTQVLGGYLADRFGGKKVLLLAVALWSLATLLT 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490232023 113 GMTSN----AMLLAIFwgINGWAQSMGVgPCVVSL-ARWYGCKERGTFYAIWSTAHNIGEAMTYMVIAAVIAGFGWQMGY 187
Cdd:cd17380 82 PLLAYsslpLLILSRI--LLGLGEGVHF-PSMTSLfSRWVPVSERSRAVSIVTAGSYLGTLLGGLIGPLLLEYYGWPSVF 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490232023 188 LSTAALGAAGVVLMLLFMrdspqscgfpsinvirdepleeteargsvfknqllalrnPALWTLALASAFMYIDRYAVNSW 267
Cdd:cd17380 159 YFFGLLGLLWALVWLIYL---------------------------------------PPVWAIIVAHFCMNWGFYILLSW 199
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490232023 268 GIFFLEQdkAYSTLEASGIigVNA---IAGIAGTIIAGMLSDRFFPRNRSV-----MAGFISLLNTAGFALMLWSPHGYY 339
Cdd:cd17380 200 LPTYFHE--VLVPLAKGWV--FNVvpwLVMFPSSNVAGWLADHLISRGWTVtsvrkLMQSIGFLGPALFLLLLSHTDSFS 275
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 490232023 340 tdiLAMIIFGATIGALTCFLGGLIAV--DISSRKaAGAalgTIGIASYAGA--G-LGEFLTGIIIDKTS 403
Cdd:cd17380 276 ---LALLCMSVALGLSAFSSSGVLVNhqDIAPNY-AGI---VFGISNTAGTipGiVGVYLTGYILEATG 337
|
|
| MFS_MCT_SLC16 |
cd17352 |
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; ... |
54-402 |
1.24e-05 |
|
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; The animal Monocarboxylate transporter (MCT) family is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCT1-4 are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT8 and MCT10 are transporters which stimulate the cellular uptake of thyroid hormones such as thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). MCT10 also functions as a sodium-independent transporter that mediates the uptake or efflux of aromatic acids. Many members are orphan transporters whose substrates are yet to be determined. The MCT family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340910 [Multi-domain] Cd Length: 361 Bit Score: 47.16 E-value: 1.24e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490232023 54 KSALVELGITPTELGMIGSTLFFSYAIGKLVNGFIADHaNVVRYMSL--GLLLSAGMNLMMGMTSNAMLLAIFWGINGWA 131
Cdd:cd17352 27 VELLEEFGESTSDIAWIGSLLLGVSLFSGPLSSALVNR-FGCRPVAIagGLLAALGLLLSSFATSLWQLYLTYGVLGGLG 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490232023 132 QSMGVGPCVVSLARWYGcKERGTFYAIWSTAHNIGEAMTYMVIAAVIAGFGWQMGYLSTAALGAAGVVLMLLfmrdspqs 211
Cdd:cd17352 106 LGLIYSPAIVIVGQYFE-KKRGLATGIAVAGSGVGTFVFPPLLRYLLDNYGWRGALLILGGLCLNLCVCGLL-------- 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490232023 212 cgfpsinvirdepleeteargsvfknqLLALRNPALWTLALASAFMYIDrYAVNSWGIFFLEQDKAYSTLEASGIIGVNA 291
Cdd:cd17352 177 ---------------------------LRLLKDPTFVLLALGVSFAMLG-FFVPFVYLPSYAKSLGIDESDAAFLLSIIG 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490232023 292 IAGIAGTIIAGMLSDRFFPRNRSVMAGFISLLNTAgfALMLWSPHGYYTDILAMIIFGATIGALTCFLgGLIAVDISSRK 371
Cdd:cd17352 229 ISDIVGRILLGLLADKPRIGRLYLYIFTLLILGLS--LLAFPLATTYVGLIVFSVLFGFCSGSYSSLT-PVILADLVGLE 305
|
330 340 350
....*....|....*....|....*....|.
gi 490232023 372 AAGAALGTIGIASYAGAGLGEFLTGIIIDKT 402
Cdd:cd17352 306 KLSNAYGLVLLFQGLAALVGPPIAGLLRDYT 336
|
|
| MFS_MosC_like |
cd17393 |
Membrane protein MosC and similar proteins of the Major Facilitator Superfamily of ... |
70-404 |
1.64e-05 |
|
Membrane protein MosC and similar proteins of the Major Facilitator Superfamily of transporters; The gene encoding Sinorhizobium meliloti membrane protein MosC is part of the mos locus, which encodes the biosynthesis of the rhizopine 3-O-methyl-scyllo-inosamine. MosC belongs to the bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4 (FucP/MFSD4) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340951 [Multi-domain] Cd Length: 373 Bit Score: 46.87 E-value: 1.64e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490232023 70 IGSTLFFSYAiGKLVNGFiaDHANVVRYMSLGLLLSAgmnLMMGMTSNAMLLAI---FWGINGWAQSMGVGPCVVSLARW 146
Cdd:cd17393 45 VGALVAMPLA-GRLVARF--GSRRVTRLGALLLLLAL---LLLGLAPSVPALALalfLFGAANGALDVAMNAQGVAVERA 118
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490232023 147 YGCKERGTFYAIWSTAHNIGEAMTYMVIAAviaGFGWQMGYLSTAALGAAGVVLMLLFmrdspqscgFPSINVIRDEPLE 226
Cdd:cd17393 119 YGRPIMSSLHAMWSLGGLAGALLGAAAIGA---GVSPGVHLLAAAVLLLLAALVAIRA---------LLPGTGEAAEDRP 186
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490232023 227 ETEARGsvfknqLLALRNPALWTLALASAFMYIDRYAVNSWGIFFLEQDKAYSTLEASGIIGVNAIAGIAGTIIAGMLSD 306
Cdd:cd17393 187 DGAGKP------GFLLPNRLLLLLGLLALAAALAEGAAADWSALYLRDVLGASAALAALGYAVFSLAMTVGRLFGDRLVD 260
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490232023 307 RFFPRnRSVMAGfiSLLNTAGFALMLWSPhgyyTDILAMIIFGAT-IGALTCFLGGLIAVDISSRKAAGAALGTIGIASY 385
Cdd:cd17393 261 RFGDV-AVLRAG--ALLAALGLLLALLAP----SVWVALAGFALMgLGLSVVVPLAFSAAGALPGLAAGIAVARVATLGY 333
|
330
....*....|....*....
gi 490232023 386 AGAGLGEFLTGIIIDKTSM 404
Cdd:cd17393 334 LGFLVGPPLIGFLADATGL 352
|
|
| MFS_FEN2_like |
cd17327 |
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; ... |
143-354 |
2.26e-05 |
|
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; This family is composed of Saccharomyces cerevisiae pantothenate transporter FEN2 (or fenpropimorph resistance protein 2) and similar proteins from fungi and bacteria including fungal vitamin H transporter, allantoate permease, and high-affinity nicotinic acid transporter, as well as Pseudomonas putida phthalate transporter and nicotinate degradation protein T (nicT). These proteins are involved in the uptake into the cell of specific substrates such as pathothenate, biotin, allantoate, and nicotinic acid, among others. The FEN2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340885 [Multi-domain] Cd Length: 406 Bit Score: 46.47 E-value: 2.26e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490232023 143 LARWYGCKERGTFYAIWSTAHNIGEAMTYMVIAAV-----IAGF-GWQMGYLSTAALGAAGVVLMLLFMRDSPQSCGFPS 216
Cdd:cd17327 119 LGMWYKREEQAKRIAFFYAAAGLGSIFGGLLAYGVfkilgVGGLaGWRWLFIIEGLITIIIGLVIFFWLPDNPSKAWFLT 198
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490232023 217 -----INVIR-DEPLEETEARGSVFKNQLLALRNPALWTLALASAFMYIDRYAVNSWGIFFLEQDKaYSTLEASGIIGVN 290
Cdd:cd17327 199 eeekeLAVERlRANQTGKGDQKFKWKQIKEAFKDPRTWLLFLFFFCSQITNNGISNFLPLILKSLG-FYSLQTNLLSVPI 277
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 490232023 291 AIAGIAGTIIAGMLSDRFfpRNRSVMAGFISLLNTAGFALML---WSPHGYYtdILAMIIFGATIGA 354
Cdd:cd17327 278 GALGAVSLLIAALLSDRF--KKRGLFAIFACVLALVGSIILLaapNPPGAYF--AAYILGGGSYAGF 340
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
48-434 |
3.80e-05 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 45.63 E-value: 3.80e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490232023 48 LSFTVAKSALVELGITPTELGMIGSTLFFSYAIGKLVNGFIADHANVVRYMSLGLLLSAGMNLMMGMTSNAMLLAIFWGI 127
Cdd:cd17477 14 LLLPLLSLRLEREGVSTALIGLVASAYYLGILLGSPLVPRLIRRVGHIRAFAAGAAITAVSVLLLALTDSPWVWFLLRFV 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490232023 128 NGWAqsmGVGPCVVS---LARWYGCKERGTFYAIWSTAHNIGEAMTYMVIAAViAGFGWQMGYLSTAALGAAGVVLMLLF 204
Cdd:cd17477 94 MGIG---LAGLFVVSeswLNALATNENRGRVLGLYSTVLGLGFALGPLLLALV-GTAGALPFLIAAVLLLLALVPLLLTR 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490232023 205 mrdspqscgfpsinviRDEPLEETEARGSVFKnqlLALRNPALWTLALASAFMYIdryAVNSWGIFFLEQdKAYSTLEAS 284
Cdd:cd17477 170 ----------------RAAPEIEEAESISLRR---LLRIAPLALLGAFVAGFLEG---AFYSLLPLYGLR-LGLSVAQAA 226
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490232023 285 GIIGVNAIAGIAGTIIAGMLSDRFfprNRSVMAGFISLLNTAGFALMLWSPHGYYTDILAMIIFGATIGALTCfLGGLIA 364
Cdd:cd17477 227 LLLAAFVLGGLLLQWPLGWLADRF---DRRRVLLGCALLGALAALLLPLVPGLPLALLVLLFLWGGAAGPLYT-LALALA 302
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490232023 365 VDISSRKAAGAALGTIGIASYAGAGLGEFLTGIIIDKtsmiengktlydFSTLSLFWVGTGLMSALFCFT 434
Cdd:cd17477 303 GDRLPGDELVAANAALLLLYGLGSVIGPLLAGALMDA------------FGPHGLFLFLAAVALLFLLFL 360
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
237-400 |
6.47e-05 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 44.96 E-value: 6.47e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490232023 237 NQLLALRNPALWTLALASAFMYIDRYAVNSwGIFFLEQDKAYSTLEASGIIGVNAIAGIAGTIIAGMLSDRFfPRNRSVM 316
Cdd:COG2814 2 PATPRRRWLALLALALGAFLSGLGIGIVLP-ALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRF-GRRRVLL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490232023 317 AGFisLLNTAGFALMLWSPHgYYTDILAMIIFGATIGALTcFLGGLIAVDISSRKAAGAALGTIGIASYAGAGLGEFLTG 396
Cdd:COG2814 80 LGL--LLFALGSLLCALAPS-LWLLLAARFLQGLGAGALF-PAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGG 155
|
....
gi 490232023 397 IIID 400
Cdd:COG2814 156 LLAD 159
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
59-403 |
6.86e-05 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 44.89 E-value: 6.86e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490232023 59 ELGITPTELGMIGSTLFFSYAIGKLVNGFIADHANVVRYMSLGLLLSAGMNLMMGMTSNAMLLAIFWGINGWAQSMgVGP 138
Cdd:cd17489 25 DLGGSEAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLLATSVALLLVLRLIHGIGWGA-FTT 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490232023 139 CVVSLARWYGCKER-GTFYAIWSTAHNIGEAMTYMVIAAVIAGFGWQMGYLSTAALGAAGVVLMLLfmrdspqscgfpsi 217
Cdd:cd17489 104 AAATLVADIIPPSRrGEGIGYYGLATTLAMALGPALGLFLYQHLGFAVLFIVAAVLALLALLLVFL-------------- 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490232023 218 nviRDEPLEETEARGSVFKNQLLALRNPALWTLALASAFMYIDRYAVNSW-GIFFLEQDKAYSTLeasgIIGVNAIAGIA 296
Cdd:cd17489 170 ---VKDPPPVAAEEAEAGTRAFRRLVEKKVLPPALILFLASIAYGAISTFlPLYAAERGISNAGL----FFTVYAIALLL 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490232023 297 GTIIAGMLSDRFfPRNRSVMAGFISLlntAGFALMLWSPHGYYTDILAMIIFGATIGALTCFLGGLiAVDISSRKAAGAA 376
Cdd:cd17489 243 SRPFSGKLSDRK-GPKTVIIPGLLLL---ALGLLLLSFAGSPWMLLLAAVLYGLGFGLLFPALQAL-AVDLVPPHRRGAA 317
|
330 340
....*....|....*....|....*..
gi 490232023 377 LGTIGIASYAGAGLGEFLTGIIIDKTS 403
Cdd:cd17489 318 NGTFFIFFDLGIGLGGLLLGLVAELFG 344
|
|
| MFS_NIMT_CynX_like |
cd17339 |
2-nitroimidazole and cyanate transporters and similar proteins of the Major Facilitator ... |
153-402 |
4.55e-04 |
|
2-nitroimidazole and cyanate transporters and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Escherichia coli 2-nitroimidazole transporter (NIMT) and cyanate transport protein CynX, and similar proteins. NIMT, also called YeaN, confers resistance to 2-nitroimidazole, the antibacterial and antifungal antibiotic, by mediating the active efflux of this compound. CynX is part of an active transport system that transports exogenous cyanate into E. coli cells. The NIMT/CynX-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340897 [Multi-domain] Cd Length: 374 Bit Score: 42.18 E-value: 4.55e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490232023 153 GTFYAIWSTAHNIGEAM--TYMVIAAVIAGFGWQMGYLSTAALGAAGVVLMLLFMRDSPqscgfpsinviRDEPLEETEA 230
Cdd:cd17339 120 GLMTGLYTTSMNLGAALasGLSVPLAQALGGGWRGALAIWALPALLALLIWLPQLRRRK-----------RAAAAAAPLT 188
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490232023 231 RGSVfknqllaLRNPALWTLALASAFMYIDRYAVNSWGIFFLeQDKAYSTLEASGIIGVNAIAGIAGTIIAGMLSDRFfp 310
Cdd:cd17339 189 KISV-------WRSPLAWQVTLFMGLQSLLFYTLMAWLPTIL-IDAGLSAATAGWLLSLFQLVGIPASLLVPILATRL-- 258
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490232023 311 RNRSVMAGFISLLNTAGFALMLWSPHGYYtdILAMIIFGATIGALTCFLGGLIAVDISSRKAAGAALGTIGIASYAGAGL 390
Cdd:cd17339 259 KNQRPIVVLLAVLFIIGVLGLLFAPTALA--LLWAVLLGLGGGAAFSLALTLISLRSSDPAEAAALSGMAQSVGYLLAAL 336
|
250
....*....|..
gi 490232023 391 GEFLTGIIIDKT 402
Cdd:cd17339 337 GPLLFGVLHDLT 348
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
56-204 |
1.31e-03 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 40.68 E-value: 1.31e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490232023 56 ALVELGITPTELGMIGSTLFFSYAIGKLVNGFIADHANVVRYMSLGLLLSAGMNLMMGMTSNAMLLAIFWGINGWAQSMG 135
Cdd:cd06173 235 AKEVLGGGAAGYGLLLAAFGVGALLGALLLGRLSKRRRRGRLLLIGALLLGLALLVLGLSPSLWLLLAALFLLGLAGGLF 314
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 490232023 136 VGPCVVSLARWYGCKERGTFYAIWSTAHNIGEAMTYMVIAAVIAGFGWQMGYLSTAALGAAGVVLMLLF 204
Cdd:cd06173 315 NVPLNTLLQLRVPDELRGRVFSVYNALNSGAMPLGALLAGLLADALGLSAVFLLAGALLLLAALLLLLL 383
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
250-403 |
2.52e-03 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 39.71 E-value: 2.52e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490232023 250 LALASAFMYIDRYAVNSWGIFFLEQDKAYSTLEASGIIGVNAIAGIAGTIIAGMLSDRFFPRnrsvMAGFISLLNTAGFA 329
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRR----RVLLIGLLLFALGL 76
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 490232023 330 LMLWSPHGYYTDILAMIIFGATIGALTCFLGGLIAvDISSRKAAGAALGTIGIASYAGAGLGEFLTGIIIDKTS 403
Cdd:pfam07690 77 LLLLFASSLWLLLVLRVLQGLGAGALFPAALALIA-DWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFG 149
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
59-203 |
2.98e-03 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 39.48 E-value: 2.98e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490232023 59 ELGITPTELGMIGSTLFFSYAIGKLVNGFIADHANVVRY---MSLGLLLSAGMNLMMGMTSNAMLLAIFWGINGWAQSMG 135
Cdd:cd17319 209 ARGFSLKQVGLLAAIPFLAGAIGMILGGRLSDRLLRGARrlvIIIGLLLAAVGLLLAYLTTSPVVAVILLSLAGFGIGAA 288
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 490232023 136 VGPCVVSLARWYGCKERGTFYAIWSTAHNIGEAMTYMVIAAVIAGFG-WQMGYLSTAALGAAGVVLMLL 203
Cdd:cd17319 289 SPVFWSLPADLLPGEAAATAGGLINSGGNLGGFVAPLLIGYLVDATGsYTAAFLFLAAVALLAALLVLL 357
|
|
| MFS_FucP_MFSD4_like |
cd17333 |
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ... |
66-433 |
5.23e-03 |
|
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340891 [Multi-domain] Cd Length: 372 Bit Score: 38.84 E-value: 5.23e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490232023 66 ELGMIGSTLFFSYAIGKLVNGFIADHANVVRYMSLGLLLSAGMNLMMGMTSNAMLLAIFWGINGWAQSM---GVGPCVVS 142
Cdd:cd17333 32 DVSVIFSSQNAGYLIGSLLAGFLMKRLGRRRTLILGLLLISLALALIFATPSIYLFVVLMFLAGLGAGIldtGANTFVGA 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490232023 143 LarwyGCKERGTFYAIWSTAHNIGEAMTYMVIAAVIA-GFGWQMGYLSTAALGAAGVVLMLLFMRDSPQSCGFPSINVIR 221
Cdd:cd17333 112 L----FEESSATRLNVLHGFFGLGALIGPLIATSLLTsELSWSWAYLIIGLIYLLLAILILLTLFPELPSARNPQQSVGA 187
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490232023 222 DEPLEETEargsvfknqllaLRNPALWTLALASAFMYIDRYAVNSWGIFFLEQDKAYSTLEASGIIGVNAIAGIAGTIIA 301
Cdd:cd17333 188 FSASASRL------------LRNPSIILGALALFLYVGAETAFSSWVPSYLVEKKHVSDGLAGYLLSGFWVGITIGRLLG 255
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490232023 302 GMLSDRFFPRNRSVMAGFISLLntagFALMLWSPHGYYTDILAMIIFGATIGALtcFLGGLIAVDISSRKAAGAALGTIG 381
Cdd:cd17333 256 GPISRRIKPHTLLVLSGSGALL----GLLILLLAPTLVVGLVATALLGLFMAAL--FPTILSLGISNLPYAKGKGTSVLL 329
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|..
gi 490232023 382 IASYAGAGLGEFLTGIIIDKtsmiengktlydFSTLSLFWVGTGLMSALFCF 433
Cdd:cd17333 330 AAGSIGGAIIPFIMGFIAEA------------VGIQTAMLLITILYAIIFVL 369
|
|
| |
