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Conserved domains on  [gi|490227958|ref|WP_004126306|]
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MULTISPECIES: lysozyme [Klebsiella]

Protein Classification

lysozyme( domain architecture ID 10091405)

lysozyme, also called endolysin or muramidase, hydrolyzes (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins; similar to Salmonella virus P22 endolysin

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
lyz_endolysin_autolysin cd00737
endolysin and autolysin; The dsDNA phages of eubacteria use endolysins or muralytic enzymes in ...
 12-137 2.60e-27

endolysin and autolysin; The dsDNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell walls. Similarly, bacteria produce autolysins to facilitate the biosynthesis of its cell wall heteropolymer peptidoglycan and cell division. Endolysins and autolysins are found in viruses and bacteria, respectively. Both endolysin and autolysin enzymes cleave the glycosidic beta 1,4-bonds between the N-acetylmuramic acid and the N-acetylglucosamine of the peptidoglycan.


:

Pssm-ID: 381599 [Multi-domain]  Cd Length: 136  Bit Score: 98.36  E-value: 2.60e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490227958  12 GLEFIKRAQGLSLVPYRDENGLRVIGYGHVLNDFETF-SHFTREVAETLLTVDLLQCQRELKRSLRVTLNQAQYDALVSL 90
Cdd:cd00737    1 GLDLIKEFEGLRLKAYRDPAGVWTIGYGHTGGVVVKPgDTITEAQAEALLRQDLARFEAAVNRLVKVPLNQNQFDALVSF 80

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 490227958  91 AFSCGPASPALNLVLTHLNQQRFAEA---LKAWeNIRSGREQ------RREECARF 137
Cdd:cd00737   81 AFNVGAGAFKSSTLLRKLNAGDYAGAadeFLRW-NKAGGKVLpglvrrRAAEAALF 135
 
Name Accession Description Interval E-value
lyz_endolysin_autolysin cd00737
endolysin and autolysin; The dsDNA phages of eubacteria use endolysins or muralytic enzymes in ...
 12-137 2.60e-27

endolysin and autolysin; The dsDNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell walls. Similarly, bacteria produce autolysins to facilitate the biosynthesis of its cell wall heteropolymer peptidoglycan and cell division. Endolysins and autolysins are found in viruses and bacteria, respectively. Both endolysin and autolysin enzymes cleave the glycosidic beta 1,4-bonds between the N-acetylmuramic acid and the N-acetylglucosamine of the peptidoglycan.


Pssm-ID: 381599 [Multi-domain]  Cd Length: 136  Bit Score: 98.36  E-value: 2.60e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490227958  12 GLEFIKRAQGLSLVPYRDENGLRVIGYGHVLNDFETF-SHFTREVAETLLTVDLLQCQRELKRSLRVTLNQAQYDALVSL 90
Cdd:cd00737    1 GLDLIKEFEGLRLKAYRDPAGVWTIGYGHTGGVVVKPgDTITEAQAEALLRQDLARFEAAVNRLVKVPLNQNQFDALVSF 80

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 490227958  91 AFSCGPASPALNLVLTHLNQQRFAEA---LKAWeNIRSGREQ------RREECARF 137
Cdd:cd00737   81 AFNVGAGAFKSSTLLRKLNAGDYAGAadeFLRW-NKAGGKVLpglvrrRAAEAALF 135
RrrD COG3772
Phage-related lysozyme (muramidase), GH24 family [Cell wall/membrane/envelope biogenesis];
8-120 1.93e-23

Phage-related lysozyme (muramidase), GH24 family [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442986 [Multi-domain]  Cd Length: 146  Bit Score: 88.74  E-value: 1.93e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490227958   8 LSLQGLEFIKRAQGLSLVPYRDENGLRVIGYGHVLNDFETFSHFTREVAETLLTVDLLQCQRELKRSLRVTLNQAQYDAL 87
Cdd:COG3772    4 TSAAGLALIKEFEGFRLKAYRDPAGVWTIGYGHTGKDVKPGDTITEEEAEALLAADLAKAEAAVRRLVKVPLTQNQFDAL 83

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 490227958  88 VSLAFSCGPASPALNLVLTHLNQQRF---AEALKAW 120
Cdd:COG3772   84 VSFAYNVGAGAFCRSTLLRKLNAGDYagaCDELLRW 119
Phage_lysozyme pfam00959
Phage lysozyme; This family includes lambda phage lysozyme and E. coli endolysin.
 35-128 6.79e-08

Phage lysozyme; This family includes lambda phage lysozyme and E. coli endolysin.


Pssm-ID: 395766 [Multi-domain]  Cd Length: 107  Bit Score: 47.73  E-value: 6.79e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490227958   35 VIGYGHVLNDFETFSHFTREVAETLLTVDLLQCQRELKRSLRVT-LNQAQYDALVSLAFSCGPASPALNLVLTHLNQQRF 113
Cdd:pfam00959   3 TIGIGHNGKDVSPHPRATKSEAAGRLQIDLDTAERCINQYHKVKdFNPNQQDALVSLAFNVGCGKRGFSTLLRAGNIGQW 82

                          90
                  ....*....|....*.
gi 490227958  114 AEALKA-WENIRSGRE 128
Cdd:pfam00959  83 IKACSAiWKSLKAGKV 98
 
Name Accession Description Interval E-value
lyz_endolysin_autolysin cd00737
endolysin and autolysin; The dsDNA phages of eubacteria use endolysins or muralytic enzymes in ...
 12-137 2.60e-27

endolysin and autolysin; The dsDNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell walls. Similarly, bacteria produce autolysins to facilitate the biosynthesis of its cell wall heteropolymer peptidoglycan and cell division. Endolysins and autolysins are found in viruses and bacteria, respectively. Both endolysin and autolysin enzymes cleave the glycosidic beta 1,4-bonds between the N-acetylmuramic acid and the N-acetylglucosamine of the peptidoglycan.


Pssm-ID: 381599 [Multi-domain]  Cd Length: 136  Bit Score: 98.36  E-value: 2.60e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490227958  12 GLEFIKRAQGLSLVPYRDENGLRVIGYGHVLNDFETF-SHFTREVAETLLTVDLLQCQRELKRSLRVTLNQAQYDALVSL 90
Cdd:cd00737    1 GLDLIKEFEGLRLKAYRDPAGVWTIGYGHTGGVVVKPgDTITEAQAEALLRQDLARFEAAVNRLVKVPLNQNQFDALVSF 80

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 490227958  91 AFSCGPASPALNLVLTHLNQQRFAEA---LKAWeNIRSGREQ------RREECARF 137
Cdd:cd00737   81 AFNVGAGAFKSSTLLRKLNAGDYAGAadeFLRW-NKAGGKVLpglvrrRAAEAALF 135
RrrD COG3772
Phage-related lysozyme (muramidase), GH24 family [Cell wall/membrane/envelope biogenesis];
8-120 1.93e-23

Phage-related lysozyme (muramidase), GH24 family [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442986 [Multi-domain]  Cd Length: 146  Bit Score: 88.74  E-value: 1.93e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490227958   8 LSLQGLEFIKRAQGLSLVPYRDENGLRVIGYGHVLNDFETFSHFTREVAETLLTVDLLQCQRELKRSLRVTLNQAQYDAL 87
Cdd:COG3772    4 TSAAGLALIKEFEGFRLKAYRDPAGVWTIGYGHTGKDVKPGDTITEEEAEALLAADLAKAEAAVRRLVKVPLTQNQFDAL 83

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 490227958  88 VSLAFSCGPASPALNLVLTHLNQQRF---AEALKAW 120
Cdd:COG3772   84 VSFAYNVGAGAFCRSTLLRKLNAGDYagaCDELLRW 119
lyz_P1 cd16901
P1 lysozyme Lyz-like proteins; Enterobacteria phage P1 lysozyme Lyz is secreted to the ...
 8-134 1.22e-14

P1 lysozyme Lyz-like proteins; Enterobacteria phage P1 lysozyme Lyz is secreted to the Escherichia coli periplasm where it is membrane bound and inactive. Activation involves the release from the membrane, an intramolecular thiol-disulfide isomerization and extensive structural rearrangement of the N-terminal region. The dsDNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell walls. Similarly, bacteria produce autolysins to facilitate the biosynthesis of its cell wall heteropolymer peptidoglycan and cell division. Endolysins and autolysins are found in viruses and bacteria, respectively. Both endolysin and autolysin enzymes cleave the glycosidic beta 1,4-bonds between the N-acetylmuramic acid and the N-acetylglucosamine of the peptidoglycan.


Pssm-ID: 381620 [Multi-domain]  Cd Length: 140  Bit Score: 66.09  E-value: 1.22e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490227958   8 LSLQGLEFIKRAQGLSLVPYRDENGLRVIGYGH----VLNDFETfshfTREVAETLLTvDLLQCQRELKRSLR-VTLNQA 82
Cdd:cd16901    2 TSAAGLELIANAEGCRRDPYKCPAGVPTIGIGSthgvKPGDRYT----DEQAAKRLAK-DIKKAERCVNRCFNgVPLPQG 76

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 490227958  83 QYDALVSLAFSCGPASPALNLVLTHLNQQRFAEA---LKAWenIRSG----------REQRREEC 134
Cdd:cd16901   77 EFDAYVSFAFNVGCGAFCKSTIYKKLQAGDYAAAcnqLPRW--VYAGgkvlpglvtrRQKERALC 139
T4-like_lys cd00735
bacteriophage T4-like lysozymes; Bacteriophage T4-like lysozymes hydrolyze the beta-1, ...
 14-133 5.01e-08

bacteriophage T4-like lysozymes; Bacteriophage T4-like lysozymes hydrolyze the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetylglucosamine (GlcNAc) in peptidoglycan heteropolymers of prokaryotic cell walls. Members include a variety of bacteriophages (T4, RB49, RB69, Aeh1), as well as Dictyostelium.


Pssm-ID: 381597  Cd Length: 146  Bit Score: 48.91  E-value: 5.01e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490227958  14 EFIKRAQGLSLVPYRDENGLRVIGYGHVLNDFETFSH---FTREVAETLLTVDLLQCQRELKRSLRVT-----LNQAQYD 85
Cdd:cd00735    4 EMLRQDEGYRLKAYKDTEGYPTIGIGHLIGKKGASLTngtITKDEAEALFEQDVDRAVRDMLRNPKLApvyaqLNAARRM 83

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 490227958  86 ALVSLAFSCGPASPA-LNLVLTHLNQQRFAEALKA-----WENIRSGREQRREE 133
Cdd:cd00735   84 ALINMAFQMGVGGLAkFKNMLAAIKAGDWEEAADGmlnslWAKQTPNRANRVSA 137
Phage_lysozyme pfam00959
Phage lysozyme; This family includes lambda phage lysozyme and E. coli endolysin.
 35-128 6.79e-08

Phage lysozyme; This family includes lambda phage lysozyme and E. coli endolysin.


Pssm-ID: 395766 [Multi-domain]  Cd Length: 107  Bit Score: 47.73  E-value: 6.79e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 490227958   35 VIGYGHVLNDFETFSHFTREVAETLLTVDLLQCQRELKRSLRVT-LNQAQYDALVSLAFSCGPASPALNLVLTHLNQQRF 113
Cdd:pfam00959   3 TIGIGHNGKDVSPHPRATKSEAAGRLQIDLDTAERCINQYHKVKdFNPNQQDALVSLAFNVGCGKRGFSTLLRAGNIGQW 82

                          90
                  ....*....|....*.
gi 490227958  114 AEALKA-WENIRSGRE 128
Cdd:pfam00959  83 IKACSAiWKSLKAGKV 98
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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