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Conserved domains on  [gi|489997444|ref|WP_003900449|]
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MULTISPECIES: type II toxin-antitoxin system RelE/ParE family toxin [Mycobacterium]

Protein Classification

type II toxin-antitoxin system RelE/ParE family toxin( domain architecture ID 10008709)

type II toxin-antitoxin (TA) system RelE/ParE family toxin similar to Mycobacterium tuberculosis HigB2 and HigB3, putative toxin components of HigB-HigA TA modules

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
COG4683 COG4683
Uncharacterized conserved protein [Function unknown];
77-191 1.13e-58

Uncharacterized conserved protein [Function unknown];


:

Pssm-ID: 443719  Cd Length: 119  Bit Score: 180.00  E-value: 1.13e-58
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489997444  77 WTADV-ERISAWLNGLDRETYELVFAAIEVLEEEGPALGCPLVDTVRGSRHKNMKELRPGSQGRsEVRILFAFDPARQAI 155
Cdd:COG4683    3 WEVEFtDEFEEWFDALDEDVQEEVLAALLLLEEFGPQLGRPYVDTLKGSRHANMKELRVQSAGG-PIRVFFAFDPRRQAI 81

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 489997444 156 MLAAGNKAGRWTQWYDEKIKAADEMFAEHLAQFEDT 191
Cdd:COG4683   82 LLVAGDKSGNEKRFYRQLIPIADRRFDEHLAELKKE 117
 
Name Accession Description Interval E-value
COG4683 COG4683
Uncharacterized conserved protein [Function unknown];
77-191 1.13e-58

Uncharacterized conserved protein [Function unknown];


Pssm-ID: 443719  Cd Length: 119  Bit Score: 180.00  E-value: 1.13e-58
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489997444  77 WTADV-ERISAWLNGLDRETYELVFAAIEVLEEEGPALGCPLVDTVRGSRHKNMKELRPGSQGRsEVRILFAFDPARQAI 155
Cdd:COG4683    3 WEVEFtDEFEEWFDALDEDVQEEVLAALLLLEEFGPQLGRPYVDTLKGSRHANMKELRVQSAGG-PIRVFFAFDPRRQAI 81

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 489997444 156 MLAAGNKAGRWTQWYDEKIKAADEMFAEHLAQFEDT 191
Cdd:COG4683   82 LLVAGDKSGNEKRFYRQLIPIADRRFDEHLAELKKE 117
Gp49 pfam05973
Phage derived protein Gp49-like (DUF891); This family consists of hypothetical bacterial ...
 86-181 2.56e-23

Phage derived protein Gp49-like (DUF891); This family consists of hypothetical bacterial proteins of unknown function as well as phage Gp49 proteins.


Pssm-ID: 461791  Cd Length: 90  Bit Score: 88.79  E-value: 2.56e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489997444   86 AWLNGLDRETYELVFAAIEVLEEEGPALGCPLVDTVRGsrhkNMKELRPGSQGRsEVRILFAFDPARQAIMLAAGNKAGr 165
Cdd:pfam05973   1 DELDALPDKVRAKFLAALDLLEEGGPDLGKPLVKKLGG----GLWELRVRDAGG-IYRVLYAFDPGRAVYVLHAFQKKT- 74

                          90
                  ....*....|....*.
gi 489997444  166 wTQWYDEKIKAADEMF 181
Cdd:pfam05973  75 -QKTPKKEIDLAERRL 89
 
Name Accession Description Interval E-value
COG4683 COG4683
Uncharacterized conserved protein [Function unknown];
77-191 1.13e-58

Uncharacterized conserved protein [Function unknown];


Pssm-ID: 443719  Cd Length: 119  Bit Score: 180.00  E-value: 1.13e-58
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489997444  77 WTADV-ERISAWLNGLDRETYELVFAAIEVLEEEGPALGCPLVDTVRGSRHKNMKELRPGSQGRsEVRILFAFDPARQAI 155
Cdd:COG4683    3 WEVEFtDEFEEWFDALDEDVQEEVLAALLLLEEFGPQLGRPYVDTLKGSRHANMKELRVQSAGG-PIRVFFAFDPRRQAI 81

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 489997444 156 MLAAGNKAGRWTQWYDEKIKAADEMFAEHLAQFEDT 191
Cdd:COG4683   82 LLVAGDKSGNEKRFYRQLIPIADRRFDEHLAELKKE 117
Gp49 pfam05973
Phage derived protein Gp49-like (DUF891); This family consists of hypothetical bacterial ...
 86-181 2.56e-23

Phage derived protein Gp49-like (DUF891); This family consists of hypothetical bacterial proteins of unknown function as well as phage Gp49 proteins.


Pssm-ID: 461791  Cd Length: 90  Bit Score: 88.79  E-value: 2.56e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489997444   86 AWLNGLDRETYELVFAAIEVLEEEGPALGCPLVDTVRGsrhkNMKELRPGSQGRsEVRILFAFDPARQAIMLAAGNKAGr 165
Cdd:pfam05973   1 DELDALPDKVRAKFLAALDLLEEGGPDLGKPLVKKLGG----GLWELRVRDAGG-IYRVLYAFDPGRAVYVLHAFQKKT- 74

                          90
                  ....*....|....*.
gi 489997444  166 wTQWYDEKIKAADEMF 181
Cdd:pfam05973  75 -QKTPKKEIDLAERRL 89
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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