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Conserved domains on  [gi|489995652|ref|WP_003898690|]
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MULTISPECIES: 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase [Mycobacterium]

Protein Classification

4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase( domain architecture ID 11479886)

4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol in isoprenoid biosynthesis

EC:  2.7.1.148
Gene Ontology:  GO:0050515|GO:0005524|GO:0016310|GO:0016114
PubMed:  12878729
SCOP:  4000959|4000643

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
PRK03188 PRK03188
4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional
 18-317 0e+00

4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional


:

Pssm-ID: 235110 [Multi-domain]  Cd Length: 300  Bit Score: 502.11  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489995652  18 VTVRVPGKVNLYLAVGDRREDGYHELTTVFHAVSLVDEVTVRNADVLSLELVGEGADQLPTDERNLAWQAAELMAEHVGR 97
Cdd:PRK03188   1 VTVRAPAKVNLHLGVGPLRDDGYHELATVFQAVSLYDEVTVTAADVLSVEVSGEGADQVPTDESNLAWRAAELLAEHVGR 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489995652  98 APDVSIMIDKSIPVAGGMAGGSADAAAVLVAMNSLWELNVPRRDLRMLAARLGSDVPFALHGGTALGTGRGEELATVLSR 177
Cdd:PRK03188  81 APDVHLHIDKGIPVAGGMAGGSADAAAALVACDALWGLGLSRDELLELAAELGSDVPFALLGGTALGTGRGEQLAPVLAR 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489995652 178 NTFHWVLAFADSGLLTSAVYNELDRLREVGDPPRLGEPGPVLAALAAGDPDQLAPLLGNEMQAAAVSLDPALARALRAGV 257
Cdd:PRK03188 161 GTFHWVLAFADGGLSTPAVFRELDRLREAGDPPRLGEPDPLLAALRAGDPAQLAPLLGNDLQAAALSLRPSLRRTLRAGE 240

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 489995652 258 EAGALAGIVSGSGPTCAFLCTSASSAIDVGAQLSGAGVCRTVRVATGPVPGARVVSAPTE 317
Cdd:PRK03188 241 EAGALAGIVSGSGPTCAFLCADADSAVDVAAALSGAGVCRTVRVATGPVPGARVVSGPSE 300
 
Name Accession Description Interval E-value
PRK03188 PRK03188
4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional
 18-317 0e+00

4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional


Pssm-ID: 235110 [Multi-domain]  Cd Length: 300  Bit Score: 502.11  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489995652  18 VTVRVPGKVNLYLAVGDRREDGYHELTTVFHAVSLVDEVTVRNADVLSLELVGEGADQLPTDERNLAWQAAELMAEHVGR 97
Cdd:PRK03188   1 VTVRAPAKVNLHLGVGPLRDDGYHELATVFQAVSLYDEVTVTAADVLSVEVSGEGADQVPTDESNLAWRAAELLAEHVGR 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489995652  98 APDVSIMIDKSIPVAGGMAGGSADAAAVLVAMNSLWELNVPRRDLRMLAARLGSDVPFALHGGTALGTGRGEELATVLSR 177
Cdd:PRK03188  81 APDVHLHIDKGIPVAGGMAGGSADAAAALVACDALWGLGLSRDELLELAAELGSDVPFALLGGTALGTGRGEQLAPVLAR 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489995652 178 NTFHWVLAFADSGLLTSAVYNELDRLREVGDPPRLGEPGPVLAALAAGDPDQLAPLLGNEMQAAAVSLDPALARALRAGV 257
Cdd:PRK03188 161 GTFHWVLAFADGGLSTPAVFRELDRLREAGDPPRLGEPDPLLAALRAGDPAQLAPLLGNDLQAAALSLRPSLRRTLRAGE 240

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 489995652 258 EAGALAGIVSGSGPTCAFLCTSASSAIDVGAQLSGAGVCRTVRVATGPVPGARVVSAPTE 317
Cdd:PRK03188 241 EAGALAGIVSGSGPTCAFLCADADSAVDVAAALSGAGVCRTVRVATGPVPGARVVSGPSE 300
IspE COG1947
4-diphosphocytidyl-2C-methyl-D-erythritol kinase [Lipid transport and metabolism]; ...
 17-300 6.69e-114

4-diphosphocytidyl-2C-methyl-D-erythritol kinase [Lipid transport and metabolism]; 4-diphosphocytidyl-2C-methyl-D-erythritol kinase is part of the Pathway/BioSystem: Isoprenoid biosynthesis


Pssm-ID: 441550 [Multi-domain]  Cd Length: 281  Bit Score: 330.55  E-value: 6.69e-114
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489995652  17 SVTVRVPGKVNLYLAVGDRREDGYHELTTVFHAVSLVDEVTVRNADVLSLELVGEGADqLPTDERNLAWQAAELMAEHVG 96
Cdd:COG1947    1 SLTVKAPAKINLFLHVTGRRPDGYHELETVFQFIDLGDTLTIEPADDGSISLTGPGAG-VPTDEDNLVYRAARLLQEATG 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489995652  97 RAPDVSIMIDKSIPVAGGMAGGSADAAAVLVAMNSLWELNVPRRDLRMLAARLGSDVPFALHGGTALGTGRGEELATVLS 176
Cdd:COG1947   80 IPPGVDIHLEKRIPVGAGLGGGSSDAAATLRALNRLWGLGLSREELAELAAKLGADVPFFLYGGTALAEGRGEKLTPLPP 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489995652 177 RNTFHWVLAFADSGLLTSAVYNELDRLREVGDPPrlgePGPVLAALAAGDpDQLAPLLGNEMQAAAVSLDPALARALRAG 256
Cdd:COG1947  160 LPELWLVLVKPGVGVSTAEVYRALDLTRDTPPPD----IDALLAALAAGD-AALAALLRNDLEPVAFKLYPEIAEVLEAL 234

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....
gi 489995652 257 VEAGALAGIVSGSGPTCAFLCTSASSAIDVGAQLSGAGVCRTVR 300
Cdd:COG1947  235 LEAGALAARMSGSGSTVFGLFEDEEAAEAAAAALPARGGVFVAR 278
ispE TIGR00154
4-diphosphocytidyl-2C-methyl-D-erythritol kinase; Members of this family of GHMP kinases were ...
 17-289 5.29e-50

4-diphosphocytidyl-2C-methyl-D-erythritol kinase; Members of this family of GHMP kinases were previously designated as conserved hypothetical protein YchB or as isopentenyl monophosphate kinase. It is now known, in tomato and E. coli, to encode 4-diphosphocytidyl-2C-methyl-D-erythritol kinase, an enzyme of the deoxyxylulose phosphate pathway of terpenoid biosynthesis. [Biosynthesis of cofactors, prosthetic groups, and carriers, Other]


Pssm-ID: 188029 [Multi-domain]  Cd Length: 294  Bit Score: 168.07  E-value: 5.29e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489995652   17 SVTVRVPGKVNLYLAVGDRREDGYHELTTVFHAVSLVDEVTVR-NADVLSLELVGEgaDQLPTDErNLAWQAAELMAEHV 95
Cdd:TIGR00154   2 RHVFPAPAKINLFLYILGKRPDGYHELQMLMQFIDLGDKIIISvRSDDDIRLLKGD--FDVPLEE-NLAYRAAQLLKNFA 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489995652   96 GRAPD----VSIMIDKSIPVAGGMAGGSADAAAVLVAMNSLWELNVPRRDLRMLAARLGSDVPFALHGGTALGTGRGEEL 171
Cdd:TIGR00154  79 NSKIKsldgVNIEITKNIPMAAGLGGGSSDAAAVLVGLNQLWNLGLSLEELAELGATLGADVPFFVSGGTAFATGRGEII 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489995652  172 ATVLSRNTFHWVLAFADSGLLTSAVYN--ELDRLrevgDPPRLGEpgpVLAALAAGDPDQLAPLLGNEMQAAAVSLDPAL 249
Cdd:TIGR00154 159 TPFEDPPEKWVVIAKPHVSVSTPVVYQayKLPRN----TPKRAKE---WLKKISLECLQLLDSNGLNDLEKVALKRHTEV 231

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|
gi 489995652  250 ARALRAGVEAGALAGIVSGSGPTCAFLCTSASSAIDVGAQ 289
Cdd:TIGR00154 232 AQALNWLLEYGLAPERMSGSGPCVFALFDMESEAEQVLEQ 271
GHMP_kinases_N pfam00288
GHMP kinases N terminal domain; This family includes homoserine kinases, galactokinases and ...
 102-160 5.38e-10

GHMP kinases N terminal domain; This family includes homoserine kinases, galactokinases and mevalonate kinases.


Pssm-ID: 395225 [Multi-domain]  Cd Length: 64  Bit Score: 54.48  E-value: 5.38e-10
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 489995652  102 SIMIDKSIPVAGGMAGGSADAAAVLVAMNSLWELNVPRRDLRM-----LAARLGSDVPFALHGG 160
Cdd:pfam00288   1 DIEIESNIPLGAGLGSSAALAVALLLALNELFGLPLAKLALEAeelagGGRGGGMDVAASLYGG 64
 
Name Accession Description Interval E-value
PRK03188 PRK03188
4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional
 18-317 0e+00

4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional


Pssm-ID: 235110 [Multi-domain]  Cd Length: 300  Bit Score: 502.11  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489995652  18 VTVRVPGKVNLYLAVGDRREDGYHELTTVFHAVSLVDEVTVRNADVLSLELVGEGADQLPTDERNLAWQAAELMAEHVGR 97
Cdd:PRK03188   1 VTVRAPAKVNLHLGVGPLRDDGYHELATVFQAVSLYDEVTVTAADVLSVEVSGEGADQVPTDESNLAWRAAELLAEHVGR 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489995652  98 APDVSIMIDKSIPVAGGMAGGSADAAAVLVAMNSLWELNVPRRDLRMLAARLGSDVPFALHGGTALGTGRGEELATVLSR 177
Cdd:PRK03188  81 APDVHLHIDKGIPVAGGMAGGSADAAAALVACDALWGLGLSRDELLELAAELGSDVPFALLGGTALGTGRGEQLAPVLAR 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489995652 178 NTFHWVLAFADSGLLTSAVYNELDRLREVGDPPRLGEPGPVLAALAAGDPDQLAPLLGNEMQAAAVSLDPALARALRAGV 257
Cdd:PRK03188 161 GTFHWVLAFADGGLSTPAVFRELDRLREAGDPPRLGEPDPLLAALRAGDPAQLAPLLGNDLQAAALSLRPSLRRTLRAGE 240

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 489995652 258 EAGALAGIVSGSGPTCAFLCTSASSAIDVGAQLSGAGVCRTVRVATGPVPGARVVSAPTE 317
Cdd:PRK03188 241 EAGALAGIVSGSGPTCAFLCADADSAVDVAAALSGAGVCRTVRVATGPVPGARVVSGPSE 300
IspE COG1947
4-diphosphocytidyl-2C-methyl-D-erythritol kinase [Lipid transport and metabolism]; ...
 17-300 6.69e-114

4-diphosphocytidyl-2C-methyl-D-erythritol kinase [Lipid transport and metabolism]; 4-diphosphocytidyl-2C-methyl-D-erythritol kinase is part of the Pathway/BioSystem: Isoprenoid biosynthesis


Pssm-ID: 441550 [Multi-domain]  Cd Length: 281  Bit Score: 330.55  E-value: 6.69e-114
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489995652  17 SVTVRVPGKVNLYLAVGDRREDGYHELTTVFHAVSLVDEVTVRNADVLSLELVGEGADqLPTDERNLAWQAAELMAEHVG 96
Cdd:COG1947    1 SLTVKAPAKINLFLHVTGRRPDGYHELETVFQFIDLGDTLTIEPADDGSISLTGPGAG-VPTDEDNLVYRAARLLQEATG 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489995652  97 RAPDVSIMIDKSIPVAGGMAGGSADAAAVLVAMNSLWELNVPRRDLRMLAARLGSDVPFALHGGTALGTGRGEELATVLS 176
Cdd:COG1947   80 IPPGVDIHLEKRIPVGAGLGGGSSDAAATLRALNRLWGLGLSREELAELAAKLGADVPFFLYGGTALAEGRGEKLTPLPP 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489995652 177 RNTFHWVLAFADSGLLTSAVYNELDRLREVGDPPrlgePGPVLAALAAGDpDQLAPLLGNEMQAAAVSLDPALARALRAG 256
Cdd:COG1947  160 LPELWLVLVKPGVGVSTAEVYRALDLTRDTPPPD----IDALLAALAAGD-AALAALLRNDLEPVAFKLYPEIAEVLEAL 234

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....
gi 489995652 257 VEAGALAGIVSGSGPTCAFLCTSASSAIDVGAQLSGAGVCRTVR 300
Cdd:COG1947  235 LEAGALAARMSGSGSTVFGLFEDEEAAEAAAAALPARGGVFVAR 278
ispE TIGR00154
4-diphosphocytidyl-2C-methyl-D-erythritol kinase; Members of this family of GHMP kinases were ...
 17-289 5.29e-50

4-diphosphocytidyl-2C-methyl-D-erythritol kinase; Members of this family of GHMP kinases were previously designated as conserved hypothetical protein YchB or as isopentenyl monophosphate kinase. It is now known, in tomato and E. coli, to encode 4-diphosphocytidyl-2C-methyl-D-erythritol kinase, an enzyme of the deoxyxylulose phosphate pathway of terpenoid biosynthesis. [Biosynthesis of cofactors, prosthetic groups, and carriers, Other]


Pssm-ID: 188029 [Multi-domain]  Cd Length: 294  Bit Score: 168.07  E-value: 5.29e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489995652   17 SVTVRVPGKVNLYLAVGDRREDGYHELTTVFHAVSLVDEVTVR-NADVLSLELVGEgaDQLPTDErNLAWQAAELMAEHV 95
Cdd:TIGR00154   2 RHVFPAPAKINLFLYILGKRPDGYHELQMLMQFIDLGDKIIISvRSDDDIRLLKGD--FDVPLEE-NLAYRAAQLLKNFA 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489995652   96 GRAPD----VSIMIDKSIPVAGGMAGGSADAAAVLVAMNSLWELNVPRRDLRMLAARLGSDVPFALHGGTALGTGRGEEL 171
Cdd:TIGR00154  79 NSKIKsldgVNIEITKNIPMAAGLGGGSSDAAAVLVGLNQLWNLGLSLEELAELGATLGADVPFFVSGGTAFATGRGEII 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489995652  172 ATVLSRNTFHWVLAFADSGLLTSAVYN--ELDRLrevgDPPRLGEpgpVLAALAAGDPDQLAPLLGNEMQAAAVSLDPAL 249
Cdd:TIGR00154 159 TPFEDPPEKWVVIAKPHVSVSTPVVYQayKLPRN----TPKRAKE---WLKKISLECLQLLDSNGLNDLEKVALKRHTEV 231

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|
gi 489995652  250 ARALRAGVEAGALAGIVSGSGPTCAFLCTSASSAIDVGAQ 289
Cdd:TIGR00154 232 AQALNWLLEYGLAPERMSGSGPCVFALFDMESEAEQVLEQ 271
PRK14608 PRK14608
4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional
 14-293 9.59e-48

4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional


Pssm-ID: 237765 [Multi-domain]  Cd Length: 290  Bit Score: 161.95  E-value: 9.59e-48
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489995652  14 PTGSVTVRVPGKVNLYLAVGDRREDGYHELTTVFHAVSLVDEVTVRNADVLSLELVGEGADQLPTDERNLAWQAAELMAE 93
Cdd:PRK14608   3 AMPSLTEFAPAKINLALHVTGRRADGYHLLESLVAFADVGDRLTLEPAEALSLTVSGPFAAGLGDGDDNLVLRAARALRA 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489995652  94 HVGR-APDVSIMIDKSIPVAGGMAGGSADAAAVLVAMNSLWELNVPRRDLRMLAARLGSDVPFALHGGTALGTGRGEELA 172
Cdd:PRK14608  83 RVGPgLPPGAFHLEKNLPVAAGIGGGSADAAAALRLLARLWGLALDDERLAALALSLGADVPVCLDSRPLIMRGIGEELT 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489995652 173 TVLSRNTFHWVLAFADSGLLTSAVYNELDRL---REVGDPPRLGEPGPVLAALAAGdpdqlapllGNEMQAAAVSLDPAL 249
Cdd:PRK14608 163 PLPGLPSLPAVLVNPGVPVATPDVFRALGLRdgpPLPGAPDPLASADALLAALAAT---------RNDLEPPALALAPVI 233

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*
gi 489995652 250 ARALRA-GVEAGALAGIVSGSGPTCAFLCTSASSAIDVGAQLSGA 293
Cdd:PRK14608 234 GEVLAAlRAQPGALLARMSGSGATCFALFADEAAAEAAAAAIAAA 278
PRK14611 PRK14611
4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase;
20-292 4.31e-43

4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase;


Pssm-ID: 184767 [Multi-domain]  Cd Length: 275  Bit Score: 149.52  E-value: 4.31e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489995652  20 VRVPGKVNLYLAVGDRREDGYHELTTVFHAVSLVDEVTVRNADVLSLELVGEgadQLPtDERNLAWQAAELMAEHVGRAP 99
Cdd:PRK14611   4 LLSPAKVNLGLWILGKRPDGYHEIFTIYHTIDLYDRIYIKEHHTLEVKTSSP---QIK-EEENIVYKALRLFERYTGIDI 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489995652 100 DVSIMIDKSIPVAGGMAGGSADAAAVLVAMNSLWELNVPRRDLRMLAARLGSDVPFALHGGTALGTGRGEELATV---LS 176
Cdd:PRK14611  80 NYSIFIEKNIPVGAGLGGGSSNAAVVLKYLNELLGNPLSEEELFELASSISADAPFFLKGGFALGRGIGDKLEFLekpIS 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489995652 177 RNTFhwvLAFADSGLLTSAVYNELDRlREVGDPPRLGEpgpVLAALAAGDPDQLAPLLGNEMQAAAVSLDPALARALRAg 256
Cdd:PRK14611 160 REIT---LVYPNIKSSTGRVYSKVTK-QILTNKEDLNI---IISLLREGEEKKIEEVIENTLGEIALELYPEIKEVYRF- 231

                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 489995652 257 VEAGALAGIVSGSGpTCAFLCTSASSAIDVGAQLSG 292
Cdd:PRK14611 232 LEYLGYKPFVSGSG-SSVYVFGKPSEEVKKAAAVRG 266
ThrB COG0083
Homoserine kinase [Amino acid transport and metabolism]; Homoserine kinase is part of the ...
 48-313 1.22e-25

Homoserine kinase [Amino acid transport and metabolism]; Homoserine kinase is part of the Pathway/BioSystem: Threonine biosynthesis


Pssm-ID: 439853 [Multi-domain]  Cd Length: 302  Bit Score: 103.64  E-value: 1.22e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489995652  48 HAVSLVDEVTVRNADV--LSLELVGEGADQLPTDERNLAWQAAELMAEHVGRA-PDVSIMIDKSIPVAGGMaGGSAdAAA 124
Cdd:COG0083   23 LALSLYDEVEVERSDEpgLEIEIEGEGADELPTDEDNLVYQAALALLEKLGKEpPGLRIEIEKGIPLGRGL-GSSA-AAI 100

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489995652 125 V--LVAMNSLWELNVPRRDLRMLAARLGS--D--VPfALHGGTALGTGRGEELATV---LSRNtFHWVLAFADSGLLTS- 194
Cdd:COG0083  101 VagLVAANALLGLPLSKEELLELATEGEGhpDnvAP-ALLGGLVLSRSDGEPVRVVrlpVPPD-LKAVVVIPDFELSTKe 178

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489995652 195 -------------AVYNeldrlreVGdppRLGEpgpVLAALAAGDPDQLAPLLGNEM-QAAAVSLDPALARALRAGVEAG 260
Cdd:COG0083  179 aravlpkqvplkdAVFN-------SS---RAAL---LVAALATGDYELLGRAMEDRLhEPYRAKLIPGFDEVKEAALEAG 245

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 489995652 261 ALAGIVSGSGPTCAFLCTSASS---AIDVGAQLSGAGVCRTVRVATGPVPGARVVS 313
Cdd:COG0083  246 ALGAGISGAGPTVLALADDEEAeavAEAMKAAFAEAGIDARVYVLKIDNEGARVLE 301
PRK14613 PRK14613
4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase;
23-270 1.39e-22

4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase;


Pssm-ID: 173077 [Multi-domain]  Cd Length: 297  Bit Score: 95.35  E-value: 1.39e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489995652  23 PGKVNLYLAVGDRREDGYHELTTVFHAVSLVDEVTVRNADVLSLELVGEgaDQLPTDERNLAWQAAEL------------ 90
Cdd:PRK14613   4 PAKINLGLEIPFKREDGFHEIRSVFLKISWGDDIEIEPAPNGVFELFST--NEIILEKRKLYDQVSERgdikqnilyktf 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489995652  91 --MAEHVGRAPDVSIMIDKSIPVAGGMAGGSADAAAVLVAMNSlWELNVPRRDLRMLAARLGSDVPFALHGGTALGTGRG 168
Cdd:PRK14613  82 ikARSLFPELPGVKIHLTKRISPAGGLGGGSTNAASLLNFLFS-WRNFFTSDEMQVFAKEIGSDVPFFLGEGHAFVTGKG 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489995652 169 EELATVLSRNTFHwVLAFADSGLLTSAVYNELDR-LREvgdpPRLGEPGPVLA-----ALAAGDPDQLAPLLGNEMQAAA 242
Cdd:PRK14613 161 EIMEEIEVHKGQG-ILALTPQVMNTGEMYALLKKpLQE----SASQKNGNTLSedlisSLKVGDWVSLQGRLENDFEPVA 235

                        250       260
                 ....*....|....*....|....*...
gi 489995652 243 VSLDPALARALRAGVEAGALAGIVSGSG 270
Cdd:PRK14613 236 FQLHPELGVLKDKFLEFGSSYCSLTGSG 263
PRK01212 PRK01212
homoserine kinase; Provisional
 49-272 3.22e-20

homoserine kinase; Provisional


Pssm-ID: 234920 [Multi-domain]  Cd Length: 301  Bit Score: 88.67  E-value: 3.22e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489995652  49 AVSLVDEVTVR----NADVLSLELVGEGADQLPTD-ERNLAWQAAELMAEHVGRAPDVSIMIDKSIPVAGGMaGGSAdAA 123
Cdd:PRK01212  25 ALSLYDEVLVGdvvsVEAEFSIEVIGEGADKLPLDpEKNLVYQAALKFLEKLGKPPGLRIELEKNIPLGRGL-GSSA-AS 102

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489995652 124 AV--LVAMNSLWELNVPRRDLRMLAARLGS--D--VPfALHGGTALG-TGRGEELATVLSRNTFHWVLAFADSGLLTS-- 194
Cdd:PRK01212 103 IVagLVAANELAGLPLSKEELLQLATEGEGhpDnvAP-ALLGGLVLAlEENGVISVKIPVFDDLKWVVAIPNIELSTAea 181

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489995652 195 ------------AVYNeldrlreVGdppRLGepgpVL-AALAAGDPDqlapLLGNEMQ--------AAAVsldPALARAL 253
Cdd:PRK01212 182 ravlpkqyslkdAVFN-------SS---RAA----LLvAALYTGDYE----LAGRAMKdvlhepyrAKLI---PGFAEVR 240

                        250
                 ....*....|....*....
gi 489995652 254 RAGVEAGALAGIVSGSGPT 272
Cdd:PRK01212 241 QAALEAGALGAGISGAGPT 259
thrB TIGR00191
homoserine kinase; Homoserine kinase is part of the threonine biosynthetic pathway.Homoserine ...
 49-312 1.71e-16

homoserine kinase; Homoserine kinase is part of the threonine biosynthetic pathway.Homoserine kinase is a member of the GHMP kinases (Galactokinase, Homoserine kinase, Mevalonate kinase, Phosphomevalonate kinase) and shares with them an amino-terminal domain probably related to ATP binding.P.aeruginosa homoserine kinase seems not to be homologous (see PROSITE:PDOC0054) [Amino acid biosynthesis, Aspartate family]


Pssm-ID: 129295 [Multi-domain]  Cd Length: 302  Bit Score: 78.21  E-value: 1.71e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489995652   49 AVSLVDEVTV-----RNADVLSLELVGEGADQLPTDER-NLAWQAAELMAEHVG-RAPDVSIMIDKSIPVAGGMAGGSAD 121
Cdd:TIGR00191  22 ALSLYLGLTVtdvvaQESDDTEIEAEGEGVEKIPTEPTdNLIYQVAKRFLDQLGiRMPPVKVTLEKNIPLGRGLGSSAAA 101

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489995652  122 AAAVLVAMNSLWELNVPRRDLRMLAARL---GSDVPFALHGGTALGTGRGEELAT--VLSRNTFHWVLAFADSGLLTSAV 196
Cdd:TIGR00191 102 IVAALAAANELCGLPLSKERLLDYASELeghPDNVAPALLGGFQLAFVEDDKLEVlkIPIFSKLDWVLAIPNIEVSTAEA 181

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489995652  197 YNELDRLREVGDP-PRLGEPGPVLAALAAGDPDQLAPLLGNEM-QAAAVSLDPALARALRAGVEAGALAGIVSGSGPTCA 274
Cdd:TIGR00191 182 RAVLPKAYPRQDLvFNLSHLAGLVHAIYQKKPDLGAIMMKDRIhQPYRESLIPNLFKIKQAALEKGAYGITISGSGPTIL 261

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|.
gi 489995652  275 FLCT---SASSAIDVGAQLSGAGVCRTVRVATGPVPGARVV 312
Cdd:TIGR00191 262 AMADeefAEQKEQDLLEVLHKQGIEGTVHVLDFDNDGARVE 302
PRK04181 PRK04181
4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional
 25-169 4.18e-16

4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional


Pssm-ID: 235243  Cd Length: 257  Bit Score: 76.54  E-value: 4.18e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489995652  25 KVNLYLA-VGDRRedGYHELTTVFHAV-SLVDEVTVRNADVLSLELVGEGADQLptdERNLAWQAAELMAEHvGRAPDV- 101
Cdd:PRK04181   8 KVNIFLKiLGKRG--NYHELISRFVLVkDLFDEIEFVPKSAESFELIGNFDCPL---EENIIYKAYQELKNK-GFSNELi 81

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 489995652 102 ------SIMIDKSIPVAGGMAGGSADAAAVLVAMNSLWELNVPRRDLRMLAARLGSDVPFALHG-GTALGTGRGE 169
Cdd:PRK04181  82 effkkkAIEVEKNIPTGAGLGGGSSDAATFLLMLNEILNLKLSLEELAEIGSKVGADVAFFISGyKSANVSGIGE 156
GHMP_kinases_N pfam00288
GHMP kinases N terminal domain; This family includes homoserine kinases, galactokinases and ...
 102-160 5.38e-10

GHMP kinases N terminal domain; This family includes homoserine kinases, galactokinases and mevalonate kinases.


Pssm-ID: 395225 [Multi-domain]  Cd Length: 64  Bit Score: 54.48  E-value: 5.38e-10
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 489995652  102 SIMIDKSIPVAGGMAGGSADAAAVLVAMNSLWELNVPRRDLRM-----LAARLGSDVPFALHGG 160
Cdd:pfam00288   1 DIEIESNIPLGAGLGSSAALAVALLLALNELFGLPLAKLALEAeelagGGRGGGMDVAASLYGG 64
PduX COG4542
PduX protein involved in propanediol utilization and related proteins [Secondary metabolites ...
 71-149 2.51e-06

PduX protein involved in propanediol utilization and related proteins [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 443608 [Multi-domain]  Cd Length: 286  Bit Score: 48.31  E-value: 2.51e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489995652  71 EGADQLPtDERNLAWQAAELMAEHVGRAP-DVSIMIDKSIPVAGGMAGGSADAAAVLVAMNSLWELNVPRRDLRMLAARL 149
Cdd:COG4542   41 PGPGGIP-AERPKARRAAELTLEHLGLPPlGGRIELRSDIPVGKGMASSTADIAATARAVARALGKELSPEELARLAVAI 119
PTZ00299 PTZ00299
homoserine kinase; Provisional
 49-128 2.90e-05

homoserine kinase; Provisional


Pssm-ID: 140320  Cd Length: 336  Bit Score: 45.27  E-value: 2.90e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489995652  49 AVSLVDEVTVRNADVLSLELVGEGADQLPTDERNLAWQAAELMAEHVGRA--PDVSIMIDKSIPVAGGMAGGSADAAAVL 126
Cdd:PTZ00299  29 ALSIFMELTVEHADAFSMTVEGEGSEHISTDEDNMVVQACRLAFEEYAHKsmPPLKFIMHSNIPYGCGCGSSSAAAVAGF 108


                 ..
gi 489995652 127 VA 128
Cdd:PTZ00299 109 VA 110
PRK05905 PRK05905
4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase;
25-159 8.95e-05

4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase;


Pssm-ID: 235642  Cd Length: 258  Bit Score: 43.30  E-value: 8.95e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489995652  25 KVNLYLAVGDRRED-GYHELTTVFHAV-SLVDEVTVR--NADVLSLELVGEGADQLpTDERNLAWQAAELMAEHVGRAPD 100
Cdd:PRK05905   8 KINLGLSIYKKCKKvTKHKLESIFILVeNVYDDIEIEkiEKNIDDIHYFDETNEIL-VYSRLILVKTLEWLRDKYNIKNH 86

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 489995652 101 VSIMIDKSIPVAGGMAGGSADAAAVlvaMNSLWELNVPRR-DLRMLAARLGSDVPFALHG 159
Cdd:PRK05905  87 FKIKIKKRIPIGSGLGSGSSNAAVL---MKWILEFEGINEiNYKDVVNKLGSDIPFFLSG 143
GHMP_kinases_C pfam08544
GHMP kinases C terminal; This family includes homoserine kinases, galactokinases and ...
 218-295 8.49e-04

GHMP kinases C terminal; This family includes homoserine kinases, galactokinases and mevalonate kinases.


Pssm-ID: 430063 [Multi-domain]  Cd Length: 85  Bit Score: 37.83  E-value: 8.49e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489995652  218 VLAALAAGDPDQLAPLLGN-----EMQAAAVSLDPALARALRAGVEAGALAGI-VSGSGPTCAFLCTSASSAIDVGAQLS 291
Cdd:pfam08544   1 LLEALLRGDLEELGKLLTEsaeslEPLLVVGILPPELDELLEALLELGLGAKLsGSGGGPTVFALFKDEDDAEEVARALR 80


                  ....
gi 489995652  292 GAGV 295
Cdd:pfam08544  81 EAGK 84
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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