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Conserved domains on  [gi|489958967|ref|WP_003862274|]
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MULTISPECIES: MFS transporter [Enterobacter]

Protein Classification

MFS transporter( domain architecture ID 999995)

major facilitator superfamily (MFS) transporter facilitates the transport across cytoplasmic or internal membranes of one or more from a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides

CATH:  1.20.1250.20
Gene Ontology:  GO:0022857|GO:0055085
PubMed:  26758938|26098515
SCOP:  3000310
TCDB:  2.A.1

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MFS super family cl28910
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 24-382 1.42e-90

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


The actual alignment was detected with superfamily member cd17490:

Pssm-ID: 475125 [Multi-domain]  Cd Length: 371  Bit Score: 277.95  E-value: 1.42e-90
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489958967  24 CIHSIDAFLAPMMINQGIEPQIMGIIMGASGLATLLIRFPLGIISDVVKSRRIFIQIGLLLPIIAWPIAWLEPNAITLYL 103
Cdd:cd17490   11 SQYVYVPFLSPYAESLGASLSMIGIILGAYGISQMLLRIPLGILSDRIGKRKLFIIIGLLFTVLASLIMILFPSPWGLLI 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489958967 104 AKAADGVTAATWVLYNILFMRYFGRNEAPAAVALLALAGPIGVFLGNCIGAVLIHYFANNIAFFVSCISALVALILTTRI 183
Cdd:cd17490   91 ARFLSGIAAATWVSFTVLYASYFPPDEAAKAMGLINLVNNLGQLIAFLIGGLIAEHFGMRAPFLLAALAGVLGFILSLFI 170

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489958967 184 QDvHDPVQAPTLKAcITGARQQLADRSVWLIGILATVVILVPFATRDTLTPVYAEQLGARAGILALLGNIHLLFYGLAIA 263
Cdd:cd17490  171 KE-ERREKKPVLTE-LKELLSVLKDKKLLFFSLLAILQQMITFSTTFGFTPLIAKQLGASSFQLGLLSIIYLLPNALASL 248

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489958967 264 LCSSVFYQRLGLVKTAVLGIVLQVISTFGIPFTSNIYVIYLWQALAGFSFGMAFAAFMSLSVVNTSSDEQSTRMGLFQTI 343
Cdd:cd17490  249 LSGTLFYKKLGERNTIIIGFLLLGAYCFLIPFAPNLTLLYLLQALNGFGTGILFPLLMSLSIEGVPAEQRSTAMGFFQAI 328

                        330       340       350
                 ....*....|....*....|....*....|....*....
gi 489958967 344 YSCGMFVGPVMMGVMMQHINLSSGYILIAALSVVAAIAT 382
Cdd:cd17490  329 YALGMFLGPVLVGIISEAFGLQTGFFVIGVIALLAAILS 367
 
Name Accession Description Interval E-value
MFS_YxlH_like cd17490
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ...
 24-382 1.42e-90

Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341043 [Multi-domain]  Cd Length: 371  Bit Score: 277.95  E-value: 1.42e-90
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489958967  24 CIHSIDAFLAPMMINQGIEPQIMGIIMGASGLATLLIRFPLGIISDVVKSRRIFIQIGLLLPIIAWPIAWLEPNAITLYL 103
Cdd:cd17490   11 SQYVYVPFLSPYAESLGASLSMIGIILGAYGISQMLLRIPLGILSDRIGKRKLFIIIGLLFTVLASLIMILFPSPWGLLI 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489958967 104 AKAADGVTAATWVLYNILFMRYFGRNEAPAAVALLALAGPIGVFLGNCIGAVLIHYFANNIAFFVSCISALVALILTTRI 183
Cdd:cd17490   91 ARFLSGIAAATWVSFTVLYASYFPPDEAAKAMGLINLVNNLGQLIAFLIGGLIAEHFGMRAPFLLAALAGVLGFILSLFI 170

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489958967 184 QDvHDPVQAPTLKAcITGARQQLADRSVWLIGILATVVILVPFATRDTLTPVYAEQLGARAGILALLGNIHLLFYGLAIA 263
Cdd:cd17490  171 KE-ERREKKPVLTE-LKELLSVLKDKKLLFFSLLAILQQMITFSTTFGFTPLIAKQLGASSFQLGLLSIIYLLPNALASL 248

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489958967 264 LCSSVFYQRLGLVKTAVLGIVLQVISTFGIPFTSNIYVIYLWQALAGFSFGMAFAAFMSLSVVNTSSDEQSTRMGLFQTI 343
Cdd:cd17490  249 LSGTLFYKKLGERNTIIIGFLLLGAYCFLIPFAPNLTLLYLLQALNGFGTGILFPLLMSLSIEGVPAEQRSTAMGFFQAI 328

                        330       340       350
                 ....*....|....*....|....*....|....*....
gi 489958967 344 YSCGMFVGPVMMGVMMQHINLSSGYILIAALSVVAAIAT 382
Cdd:cd17490  329 YALGMFLGPVLVGIISEAFGLQTGFFVIGVIALLAAILS 367
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
28-348 1.39e-16

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 80.40  E-value: 1.39e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489958967  28 IDAFLAPMMINQGIEPQIMGIIMGASGLATLLIRFPLGIISDVVKSRRIFIqIGLLLPIIAWPIAWLEPNAITLYLAKAA 107
Cdd:COG2814   29 VLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLL-LGLLLFALGSLLCALAPSLWLLLAARFL 107

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489958967 108 DGV-TAATWVLYNILFMRYFGRNEAPAAVALLALAGPIGVFLGNCIGAVLIHYFANNIAFFVSCISALVALILTTRIQDV 186
Cdd:COG2814  108 QGLgAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWRWVFLVNAVLALLALLLLLRLLPE 187

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489958967 187 HDPVQAPTLKAcitGARQQLADRSVWLIGILATVVILVPFATRDTLTPVYAEQLGARAGILALLGNIHLLFyGLAIALCS 266
Cdd:COG2814  188 SRPAARARLRG---SLRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSASAAGLLLALFGLG-GVLGALLA 263

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489958967 267 SVFYQRLGLVKTAVLGIVLQVISTFGIPFTSNIYVIYLWQALAGFSFGMAFAAFMSLSVVNTSSDEQSTRMGLFQTIYSC 346
Cdd:COG2814  264 GRLADRFGRRRLLLIGLLLLALGLLLLALAGSLWLLLLALFLLGFGFGLLFPLLQALVAELAPPEARGRASGLYNSAFFL 343


                 ..
gi 489958967 347 GM 348
Cdd:COG2814  344 GG 345
MFS_1 pfam07690
Major Facilitator Superfamily;
30-352 1.60e-13

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 71.30  E-value: 1.60e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489958967   30 AFLAPMMINQGIEPQIMGIIMGASGLATLLIRFPLGIISDVVKSRRIFIqIGLLLPIIAWPIAWLEPNAITLYLAKAADG 109
Cdd:pfam07690  18 ALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLL-IGLLLFALGLLLLLFASSLWLLLVLRVLQG 96

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489958967  110 VT-AATWVLYNILFMRYFGRNEAPAAVALLALAGPIGVFLGNCIGAVLIHYFANNIAFFVSCISALVALILTTRIQDVHD 188
Cdd:pfam07690  97 LGaGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAILSLLAAVLLLLPRPPPE 176

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489958967  189 PVQAPTLKACITGARQQLAD--RSVWLIGILATVVILVPFATRDTLTPVYAEQLGARAGILALLGNIHLLFyGLAIALCS 266
Cdd:pfam07690 177 SKRPKPAEEARLSLIVAWKAllRDPVLWLLLALLLFGFAFFGLLTYLPLYQEVLGLSALLAGLLLGLGGLL-GAIGRLLL 255

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489958967  267 SVFYQRLGLVKTAVLGIVLQVISTFGI---PFTSNIYVIYLWQALAGFSFGMAFAAFMSLSVVNTSSDEQSTRMGLFQTI 343
Cdd:pfam07690 256 GRLSDRLGRRRRLLLALLLLILAALGLlllSLTLSSLWLLLALLLLGFGFGLVFPALNALVSDLAPKEERGTASGLYNTA 335


                  ....*....
gi 489958967  344 YSCGMFVGP 352
Cdd:pfam07690 336 GSLGGALGP 344
 
Name Accession Description Interval E-value
MFS_YxlH_like cd17490
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ...
 24-382 1.42e-90

Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341043 [Multi-domain]  Cd Length: 371  Bit Score: 277.95  E-value: 1.42e-90
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489958967  24 CIHSIDAFLAPMMINQGIEPQIMGIIMGASGLATLLIRFPLGIISDVVKSRRIFIQIGLLLPIIAWPIAWLEPNAITLYL 103
Cdd:cd17490   11 SQYVYVPFLSPYAESLGASLSMIGIILGAYGISQMLLRIPLGILSDRIGKRKLFIIIGLLFTVLASLIMILFPSPWGLLI 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489958967 104 AKAADGVTAATWVLYNILFMRYFGRNEAPAAVALLALAGPIGVFLGNCIGAVLIHYFANNIAFFVSCISALVALILTTRI 183
Cdd:cd17490   91 ARFLSGIAAATWVSFTVLYASYFPPDEAAKAMGLINLVNNLGQLIAFLIGGLIAEHFGMRAPFLLAALAGVLGFILSLFI 170

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489958967 184 QDvHDPVQAPTLKAcITGARQQLADRSVWLIGILATVVILVPFATRDTLTPVYAEQLGARAGILALLGNIHLLFYGLAIA 263
Cdd:cd17490  171 KE-ERREKKPVLTE-LKELLSVLKDKKLLFFSLLAILQQMITFSTTFGFTPLIAKQLGASSFQLGLLSIIYLLPNALASL 248

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489958967 264 LCSSVFYQRLGLVKTAVLGIVLQVISTFGIPFTSNIYVIYLWQALAGFSFGMAFAAFMSLSVVNTSSDEQSTRMGLFQTI 343
Cdd:cd17490  249 LSGTLFYKKLGERNTIIIGFLLLGAYCFLIPFAPNLTLLYLLQALNGFGTGILFPLLMSLSIEGVPAEQRSTAMGFFQAI 328

                        330       340       350
                 ....*....|....*....|....*....|....*....
gi 489958967 344 YSCGMFVGPVMMGVMMQHINLSSGYILIAALSVVAAIAT 382
Cdd:cd17490  329 YALGMFLGPVLVGIISEAFGLQTGFFVIGVIALLAAILS 367
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 40-382 8.35e-26

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 107.28  E-value: 8.35e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489958967  40 GIEPQIMGIIMGASGLATLLIRFPLGIISDVVkSRRIFIQIGLLLPIIAWPIAWLEPNAITLYLAKAADGV-TAATWVLY 118
Cdd:cd17325   27 GASVAQIGLIVAAYALAQLLFSPPAGRLSDRF-GRKRLLLLGLLLLAVSTLLFAFATSYWQLLLARFLQGLaSAAVWPAA 105

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489958967 119 NILFMRYFGRNEAPAAVALLALAGPIGVFLGNCIGAVLIHYFANNIAFFVSCISALVALILTTRIQDVHDPVQAPTLK-- 196
Cdd:cd17325  106 MALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLVCAALALLALVLALLLLPEPRPPPNKRAVsa 185

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489958967 197 ACITGARQQLADRSVWLIGILATVVILVPFATRDTLTPVYAEQL-GARAGILALLgnihLLFYGLAIALCSSVF---YQR 272
Cdd:cd17325  186 ARLRSGLRLLLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELgGLSPAQIGLL----FGAQGLASALSQPPAgklSDR 261

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489958967 273 LGLVKTAVLGIVLQVISTFGIPFTSNIYVIYLWQALAGFSFGMAFAAFMSLSVVNTSSDEQSTRMGLFQTIYSCGMFVGP 352
Cdd:cd17325  262 IGRKPLILIGLLLSAVALLLLPLATSFWLLLLLLALLGLGLGLVFPATLALLADIVPPEGRGTAMGLFNTAFSLGMVLGP 341

                        330       340       350
                 ....*....|....*....|....*....|
gi 489958967 353 VMMGVMMQHINLSSGYILIAALSVVAAIAT 382
Cdd:cd17325  342 LLGGFLYDAFGFATPFLAAAALLLLAAVLF 371
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
28-348 1.39e-16

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 80.40  E-value: 1.39e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489958967  28 IDAFLAPMMINQGIEPQIMGIIMGASGLATLLIRFPLGIISDVVKSRRIFIqIGLLLPIIAWPIAWLEPNAITLYLAKAA 107
Cdd:COG2814   29 VLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLL-LGLLLFALGSLLCALAPSLWLLLAARFL 107

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489958967 108 DGV-TAATWVLYNILFMRYFGRNEAPAAVALLALAGPIGVFLGNCIGAVLIHYFANNIAFFVSCISALVALILTTRIQDV 186
Cdd:COG2814  108 QGLgAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWRWVFLVNAVLALLALLLLLRLLPE 187

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489958967 187 HDPVQAPTLKAcitGARQQLADRSVWLIGILATVVILVPFATRDTLTPVYAEQLGARAGILALLGNIHLLFyGLAIALCS 266
Cdd:COG2814  188 SRPAARARLRG---SLRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSASAAGLLLALFGLG-GVLGALLA 263

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489958967 267 SVFYQRLGLVKTAVLGIVLQVISTFGIPFTSNIYVIYLWQALAGFSFGMAFAAFMSLSVVNTSSDEQSTRMGLFQTIYSC 346
Cdd:COG2814  264 GRLADRFGRRRLLLIGLLLLALGLLLLALAGSLWLLLLALFLLGFGFGLLFPLLQALVAELAPPEARGRASGLYNSAFFL 343


                 ..
gi 489958967 347 GM 348
Cdd:COG2814  344 GG 345
MFS_YfcJ_like cd17489
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ...
 30-380 5.26e-15

Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341042 [Multi-domain]  Cd Length: 367  Bit Score: 75.71  E-value: 5.26e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489958967  30 AFLAPMMINQGIEPQIMGIIMGASGLATLLIRFPLGIISDVVkSRRIFIQIGLLLPIIAWPIAWLEPNAITLYLAKAADG 109
Cdd:cd17489   17 PVLPLYAHDLGGSEAVAGLVVGLFTLAALLARPFAGRLLDRF-GRKRLLLIGLLIFALATLLYLLATSVALLLVLRLIHG 95

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489958967 110 V-TAATWVLYNILFMRYFGRNEAPAAVALLALAGPIGVFLGNCIGAVLIHYFANNIAFFVSCISALVALILTTRIQDVhd 188
Cdd:cd17489   96 IgWGAFTTAAATLVADIIPPSRRGEGIGYYGLATTLAMALGPALGLFLYQHLGFAVLFIVAAVLALLALLLVFLVKDP-- 173

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489958967 189 PVQAPTLKACITGARQQLADRSVWLIGILATVvILVPFATRDTLTPVYAEQLGARAGILALLgnihllFYGLAIALCSSV 268
Cdd:cd17489  174 PPVAAEEAEAGTRAFRRLVEKKVLPPALILFL-ASIAYGAISTFLPLYAAERGISNAGLFFT------VYAIALLLSRPF 246

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489958967 269 ---FYQRLGLVKTAVLGIVLQVISTFGIPFTSNIYVIYLWQALAGFSFGMAFAAFMSLSVVNTSSDEQSTRMGLFQTIYS 345
Cdd:cd17489  247 sgkLSDRKGPKTVIIPGLLLLALGLLLLSFAGSPWMLLLAAVLYGLGFGLLFPALQALAVDLVPPHRRGAANGTFFIFFD 326

                        330       340       350
                 ....*....|....*....|....*....|....*
gi 489958967 346 CGMFVGPVMMGVMMQHINLSSGYILIAALSVVAAI 380
Cdd:cd17489  327 LGIGLGGLLLGLVAELFGYRAMFLLAAVVVLLALV 361
MFS_MJ1317_like cd17370
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ...
 40-381 6.48e-15

MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340928 [Multi-domain]  Cd Length: 371  Bit Score: 75.66  E-value: 6.48e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489958967  40 GIEPQIMGIIMGASGLATLLIRFPLGIISDVVKSRRIFIQIGLLLPIIAWPIAWLEPNAITLYLAKAADGV-----TAAT 114
Cdd:cd17370   30 GASAAAVGLIEGLAEALGSLLRLFSGYLSDRTGKRKPLVILGYGLSALAKPLLALAGSWQLVLLLRILERLgkgirTPPR 109

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489958967 115 WVL-----YNILFMRYFGRNEAPAAvallalagpIGVFLGNCIGAVLIHYFANNI--AFFVSCISALVALILTTRIqdVH 187
Cdd:cd17370  110 DALladatPPSGRGKAFGLHRALDT---------LGAVLGPLLAALLLYLLGGNYrtIFLLAAIPALLALLILLFV--VK 178

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489958967 188 DPVQAPTLKACITGARQQLADRSVWLIgiLATVVILVPFATRDTLTPVYAEQLGARAGILALLGNIHLLFYGLAiALCSS 267
Cdd:cd17370  179 EYPRPPKLRKKSKKTSLKKLPKAFWLY--LLAVALFALGNFSFAFLILRAQELGLSAALIPLLYALFNLVYALA-AYPAG 255

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489958967 268 VFYQRLGLVKTAVLGIVLQVISTFGIPFTSNIYVIYLWQALAGFSFGMAFAAFMSLSVVNTSSDEQSTRMGLFQTIYSCG 347
Cdd:cd17370  256 RLSDRIGRKKLLILGYLSLALAYLGFALGSSLWLLLLGFILWGLYMGAQESIERAAVADLVPAELRGTAYGLFNTVVGIG 335

                        330       340       350
                 ....*....|....*....|....*....|....
gi 489958967 348 MFVGPVMMGVMMQHINLSSGYILIAALSVVAAIA 381
Cdd:cd17370  336 WLLASLIAGYLWDLISPSAAFLFSAVLALIALLL 369
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
30-398 1.05e-13

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 72.22  E-value: 1.05e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489958967  30 AFLAPMMINQ-GIEPQIMGIIMGASGLATLLIRFPLGIISDVVKSRRIFIqIGLLLPIIAWPIAWLEPNAITLYLAKAAD 108
Cdd:COG2223   25 SVLAPPLAEEfGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLL-IGLLLLGIGLLLLALAVSYWLLLLLGLLL 103

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489958967 109 GVTA-ATWVLYNILFMRYFGRNEAPAAVALLALAGPIGVFLGNCIGAVLIHYFANNIAFFVSCISALVALILTTRIQDVH 187
Cdd:COG2223  104 GIGGgGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGWRNAFLILGILLLVVAVLAWLFLRDP 183

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489958967 188 DPVQAPTLKACITGARQQLADRSVWLIGILATVVILVPFATRDTLTPVYAEQLGARAGILALLGNIHLLFYGLAIALcSS 267
Cdd:COG2223  184 PAGAAAAAKASLRDQLEALRDPRFWLLSLLYFGTFGSFIGFSSWLPPYLVDQFGLSAATAGLLAALFALLGALGRPL-GG 262

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489958967 268 VFYQRLGLVKTAVLGIVLQVISTFGIPFTS-NIYVIYLWQALAGFSFGMAFAAFMSLSVVNTSSDEQSTRMGLFQTIYSC 346
Cdd:COG2223  263 WLSDRIGGRRVLLIVFALMALGLLLLALALgSLWLFLVLFLLLGLALGGGNGAVFALVPDIFPTKNAGAVYGLVGAAGGL 342

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|...
gi 489958967 347 GMFVGPVMMGVMMQHI-NLSSGYILIAALSVVAAIATplsaRWVYARKSQTSA 398
Cdd:COG2223  343 GGFLGPLLFGALLDATgSYTAAFLVFAVLALVALVLT----LLLYRRPRRAAA 391
MFS_1 pfam07690
Major Facilitator Superfamily;
30-352 1.60e-13

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 71.30  E-value: 1.60e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489958967   30 AFLAPMMINQGIEPQIMGIIMGASGLATLLIRFPLGIISDVVKSRRIFIqIGLLLPIIAWPIAWLEPNAITLYLAKAADG 109
Cdd:pfam07690  18 ALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLL-IGLLLFALGLLLLLFASSLWLLLVLRVLQG 96

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489958967  110 VT-AATWVLYNILFMRYFGRNEAPAAVALLALAGPIGVFLGNCIGAVLIHYFANNIAFFVSCISALVALILTTRIQDVHD 188
Cdd:pfam07690  97 LGaGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAILSLLAAVLLLLPRPPPE 176

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489958967  189 PVQAPTLKACITGARQQLAD--RSVWLIGILATVVILVPFATRDTLTPVYAEQLGARAGILALLGNIHLLFyGLAIALCS 266
Cdd:pfam07690 177 SKRPKPAEEARLSLIVAWKAllRDPVLWLLLALLLFGFAFFGLLTYLPLYQEVLGLSALLAGLLLGLGGLL-GAIGRLLL 255

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489958967  267 SVFYQRLGLVKTAVLGIVLQVISTFGI---PFTSNIYVIYLWQALAGFSFGMAFAAFMSLSVVNTSSDEQSTRMGLFQTI 343
Cdd:pfam07690 256 GRLSDRLGRRRRLLLALLLLILAALGLlllSLTLSSLWLLLALLLLGFGFGLVFPALNALVSDLAPKEERGTASGLYNTA 335


                  ....*....
gi 489958967  344 YSCGMFVGP 352
Cdd:pfam07690 336 GSLGGALGP 344
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
27-387 2.44e-12

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 67.59  E-value: 2.44e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489958967  27 SIDAFLAPMMINQGIEPQIMGIIMGASGLATLLIRFPLGIISDVVkSRRIFIQIGLLLPIIAWPIAWLEPNAITLYLAKA 106
Cdd:COG2271   28 NLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRF-GRRRVLAIGLLLWGLATLLFGFATSFWQLLLLRF 106

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489958967 107 ADGV-TAATWVLYNILFMRYFGRNEAPAAVALLALAGPIGVFLGNCIGAVLIHYFANNIAFFVSCISALVALILTtriqd 185
Cdd:COG2271  107 LLGLgEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAAFGWRAAFLILGLPGLLLALLR----- 181

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489958967 186 vhdpvqaptlkacitgarqqladrsVWLIGILATVVILVPFATRDTLTPVYAEQLG---ARAGILALLGNIHLLFYGLAI 262
Cdd:COG2271  182 -------------------------FWLLALAYFLVYFALYGFLTWLPTYLVEVRGlslAQAGLLLSLPFLAGIVGSLLG 236

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489958967 263 ALCSSVFYQRLGLVktAVLGIVLQVISTFGIPFTSNIYVIYLWQALAGFSFGMAFAAFMSLSVVNTSSDEQSTRMGLFQT 342
Cdd:COG2271  237 GWLSDRLGRRRKLV--LAIGLLLAALALLLLALLPSPALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVNT 314

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....*
gi 489958967 343 IYSCGMFVGPVMMGVMMQHINLSSGYILIAALSVVAAIATPLSAR 387
Cdd:COG2271  315 FGFLGGALGPLLVGYLLDATGYQAAFLLLAALALLAALLALLLLR 359
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 27-382 9.58e-12

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 65.91  E-value: 9.58e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489958967  27 SIDAFLAPMMINQGIEPQIMGIIMGASGLATLLIRFPLGIISDVVkSRRIFIQIGLLLPIIAWPIAWLEPNAITLYLAKA 106
Cdd:cd06174   14 LISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRF-GRRPVLLLGLLLFALGALLFAFAPSFWLLLLGRF 92

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489958967 107 ADGVTAA-TWVLYNILFMRYFGRNEAPAAVALLALAGPIGVFLGNCIGAVLIHYFANN---IAFFVSCISALVALILTTR 182
Cdd:cd06174   93 LLGLGSGlIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSLGFGwraVFLIAAALALLAAILLLLV 172

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489958967 183 IQDVHDPVQAPTLKACITGARQQLADRSVWLIGILATVVILVPFATRDTLTPVYAEQLGARAGILALLGNIHLLFYGLAI 262
Cdd:cd06174  173 VPDPPESARAKNEEASSKSVLKLLKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLSVAVAGLLLSLFGLAG 252

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489958967 263 ALCSSVFYQ----RLGLVKTAVLGIVLQVISTFGIPFTSNIYVIYLWQALAGFSFGMAFAAFMSLSVVNTSSDEQSTRMG 338
Cdd:cd06174  253 ALGSLLLGLlsdrLIGRKPLLLIGLLLMALGLALLLLAPSLLLLLLLLLLLGFGLGGLLPLSFALIAELFPPEIRGTAFG 332

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....*
gi 489958967 339 LFQTIYSCGMFVGPVMMGVM-MQHINLSSGYILIAALSVVAAIAT 382
Cdd:cd06174  333 LLNTFGFLGGAIGPLLAGFLlAATFGLTGAFLVLAVLLLLAAILL 377
MFS_MefA_like cd06173
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ...
 43-385 2.13e-11

Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340863 [Multi-domain]  Cd Length: 383  Bit Score: 64.94  E-value: 2.13e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489958967  43 PQIMGIIMGASGLATLLIRFPLGIISDVVKSRRIFI--QIGLLLPIIAWPIAWLEP--NAITLYLAKAADGVTAATW-VL 117
Cdd:cd06173   33 ALLVGLVLAAFFLPFLLFSPFAGVLADRFDRRRLLIlaDLLRALLAAVLALLALLGslSLWLLLVLAFLLGIASAFFgPA 112

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489958967 118 YNILFMRYFGRNEAPAAVALLALAGPIGVFLGNCIGAVLIHYFANNIAFFVSCISALVALILTTRIQ---DVHDPVQAPT 194
Cdd:cd06173  113 RQALLPELVPKEQLVRANALNSLATQLARIIGPALGGLLVALLGPGGAFAINALSFLLSALLLLFIRrppPAAPGESSSL 192

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489958967 195 LKACITGARQQLADRSVWLIGILATVVILVPFATRDTLTPVYA-EQLGARAGILALLgnihLLFYG---LAIALCSSVFY 270
Cdd:cd06173  193 LLRDLREGLRYLRRSPLLRLLLLALALFALLGGALTVLLPLLAkEVLGGGAAGYGLL----LAAFGvgaLLGALLLGRLS 268

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489958967 271 QRLGLVKTAVLGIVLQVISTFGIPFTSNIYVIYLWQALAGFSFGMAFAAFMSLSVVNTSSDEQSTRMGLFQTIYSCGMFV 350
Cdd:cd06173  269 KRRRRGRLLLIGALLLGLALLVLGLSPSLWLLLAALFLLGLAGGLFNVPLNTLLQLRVPDELRGRVFSVYNALNSGAMPL 348

                        330       340       350
                 ....*....|....*....|....*....|....*
gi 489958967 351 GPVMMGVMMQHINLSSGYILIAALSVVAAIATPLS 385
Cdd:cd06173  349 GALLAGLLADALGLSAVFLLAGALLLLAALLLLLL 383
MFS_SLC46_TetA_like cd17330
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ...
 31-380 1.57e-10

Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340888 [Multi-domain]  Cd Length: 349  Bit Score: 62.21  E-value: 1.57e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489958967  31 FLAPMMINQGIEPQIMGIIMGASGLATLLIRFPLGIISDVVkSRRIFIQIGLLLPIIAWPIAWLEPNAITLYLAKAADGV 110
Cdd:cd17330   21 FYVREFNKLGASGYYVGLLQSSYSLGQFLASPLWGRLSDRY-GRKPVLLLSLAGSAVSYVLLGLSRNLWLLFLARFLDGL 99

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489958967 111 TAATWVLYNILFMRYFGRNEAPAAVALLALAGPIGVFLGNCIGAVLIHYFANNIAFFVSCISALVALILTTRIQdvhdpv 190
Cdd:cd17330  100 TGGNVSVAQAYIADITDEEERAKAFGIISAAFGLGFILGPALGGFLSTPYGYALPFLVAAALALLNLVLVLFFL------ 173

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489958967 191 qaptlkacitgarqqladRSVWLIgILATVVILVPFATRDTLTPVYAEQL----GARAGILALLGNIHLLFYGLAIAlcs 266
Cdd:cd17330  174 ------------------PPLRRL-LLVYFLIALAFAGLESVFSLFLKDRfgfsPSQIGLLLALVGIAGILAQLLLI--- 231

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489958967 267 SVFYQRLGLVKTAVLGIVLQVISTFGIPFTSNIYVIYLWQALAGFSFGMAFAAFMSLSVVNTSSDEQSTRMGLFQTIYSC 346
Cdd:cd17330  232 PRLAKRLGERKLLRLGLLLAIIGLLLLPFASSVPLLVLAAAILAFGTGIVFPALSALLSKSVPSKEQGKAQGIIQSLQSL 311

                        330       340       350
                 ....*....|....*....|....*....|....
gi 489958967 347 GMFVGPVMMGVMMQHINLSSGYILIAALSVVAAI 380
Cdd:cd17330  312 ARIIGPLLAGPLYSFLGPGVPFLLAAGLLLIALF 345
MFS_YfmO_like cd17474
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ...
 144-382 7.57e-10

Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341027 [Multi-domain]  Cd Length: 374  Bit Score: 60.28  E-value: 7.57e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489958967 144 IGVFLGNCIGAVL--IHYFAnniAFFVSCISALVALILTTRIQDVHDPVQAPTLKACITGARQQLADRSVWLIGILATVV 221
Cdd:cd17474  134 LGIAVGPLLGGLLaaISWRY---PFFLLAALIPVAFLAILFLLPEPKEKAKSSSATKLRDLKKALRGRGLLTFLVSAFLY 210

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489958967 222 ILVPFATRDTLTPVYAEQLGARAGILALLgnihLLFYGLAIALCSSVF----YQRLGLVKTAVLGIVLQVISTFGIPFTS 297
Cdd:cd17474  211 FFLYFAFLTYLPFLLELLYGISPIIIGLL----FAGWSVLLALGSLFVgrllKKRFGARRILVIGLLLYALSLLLLGFVP 286

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489958967 298 NIYVIYLWQALAGFSFGMAFAAFMSLSVVNTSSDEQSTRMGLFQTIYSCGMFVGPVMMGVMMQHINLSSGYILIAALSVV 377
Cdd:cd17474  287 SLALLLIAIVLFGLGLGLNLPLLTTLVTELAPEEERGTASSLYNFVRFLGQAVGPLLFGLLLEIFGLSAPFLVGAAIALA 366


                 ....*
gi 489958967 378 AAIAT 382
Cdd:cd17474  367 AAVLL 371
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
40-381 2.93e-09

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 58.37  E-value: 2.93e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489958967  40 GIEPQIMGIIMGASGLATLLIRFPLGIISDVVKS----RRIFIQIGLLLPIIAWPIAWLEPNAITLYLAKAADGVTAATW 115
Cdd:COG2211   42 GLSAALVGLILLVARLWDAITDPLIGALSDRTRTrwgrRRPWILIGAIPLALSFVLLFTAPDLSPTGKLIYALVTYLLLG 121

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489958967 116 VLYNILFMRYFG--------RNEAPAAVALLALAGPIGVFLGNCIGAVLIHYFANN------IAFFVSCISALVALILTT 181
Cdd:COG2211  122 LAYTLVNIPYSAlgaeltpdYEERTRLSSWRFAFAGLGGLLASVLPPPLVAAFGGDaalgyrLTALIFAVLGLLAFLLTF 201

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489958967 182 RIqdVHDPVQAPTLKACITGARQQLADRSVWLIGILATVVILVPFATRDTLTPVYAEQ-LGARAGILALLGNIHLLFyGL 260
Cdd:COG2211  202 FG--TKERPVPEEEKVSLKESLKALLKNRPFLLLLLAYLLFFLALALVAALLLYYFKYvLGLSAALVGLLLALYFLA-AL 278

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489958967 261 AIALCSSVFYQRLGLVKTAVLGIVLQVISTFGIPF--TSNIYVIYLWQALAGFSFGMAFAAFMSLSVVNTSSDEQST--- 335
Cdd:COG2211  279 LGAPLWPRLAKRFGKKKAFIIGLLLAALGLLLLFFlgPGNLWLLLVLAALAGIGLGAILVLPWAMLADVVDYDEWKTgrr 358

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 489958967 336 RMGLFQTIYS----CGMFVGPVMMGVMMQHINLSSG--------------YILIAALSVVAAIA 381
Cdd:COG2211  359 REGLYFGIFTfaikLGQALAGALAGLLLALFGYVAGaaqspsaltgirllFFLLPAVLLLLAAL 422
MFS_1 pfam07690
Major Facilitator Superfamily;
231-381 6.93e-09

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 57.04  E-value: 6.93e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489958967  231 TLTPVYAEQLGARAGILALLGNIHLLFYGLAIALcSSVFYQRLGLVKTAVLGIVLQVISTFGIPFTSNIYVIYLWQALAG 310
Cdd:pfam07690  18 ALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPL-AGRLSDRFGRRRVLLIGLLLFALGLLLLLFASSLWLLLVLRVLQG 96

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 489958967  311 FSFGMAFAAFMSLSVVNTSSDEQSTRMGLFQTIYSCGMFVGPVMMGVMMQHINLSSGYILIAALSVVAAIA 381
Cdd:pfam07690  97 LGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAILSLLAAVL 167
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
209-381 7.75e-09

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 56.91  E-value: 7.75e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489958967 209 RSVWLIGILATVVILVPFATRdTLTPVYAEQLGARAGILALLGNIHLLFYGLAiALCSSVFYQRLGLVKTAVLGIVLQVI 288
Cdd:COG2814   10 LALLALALGAFLSGLGIGIVL-PALPLIAADLGASPAQAGLVVTAYLLGAALG-APLAGRLADRFGRRRVLLLGLLLFAL 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489958967 289 STFGIPFTSNIYVIYLWQALAGFSFGMAFAAFMSLSVVNTSSDEQSTRMGLFQTIYSCGMFVGPVMMGVMMQHINLSSGY 368
Cdd:COG2814   88 GSLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWRWVF 167

                        170
                 ....*....|...
gi 489958967 369 ILIAALSVVAAIA 381
Cdd:COG2814  168 LVNAVLALLALLL 180
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
211-382 1.33e-08

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 56.03  E-value: 1.33e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489958967 211 VWLIGILATVVILVPFATRDTLTPVYAEQLGARAGILALLGNIHLLFYGLAiALCSSVFYQRLGLVKTAVLGIVLQVIST 290
Cdd:COG2271   11 ILALLFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALG-QIPAGLLADRFGRRRVLAIGLLLWGLAT 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489958967 291 FGIPFTSNIYVIYLWQALAGFSFGMAFAAFMSLSVVNTSSDEQSTRMGLFQTIYSCGMFVGPVMMGVMMQHINLSSGYIL 370
Cdd:COG2271   90 LLFGFATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAAFGWRAAFLI 169

                        170
                 ....*....|..
gi 489958967 371 IAALSVVAAIAT 382
Cdd:COG2271  170 LGLPGLLLALLR 181
FucP COG0738
Fucose permease [Carbohydrate transport and metabolism];
225-381 1.68e-08

Fucose permease [Carbohydrate transport and metabolism];


Pssm-ID: 440501 [Multi-domain]  Cd Length: 391  Bit Score: 56.02  E-value: 1.68e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489958967 225 PFATRDTLTPVYAEQLGARAgilALLGNIHLLFYG--LAIALCSSVFYQRLGLVKTAVLGIVLQVISTFGIPFTSNIYVI 302
Cdd:COG0738   23 ATALWGPLIPALKDAFGLSD---AQAGLLLFAFFLgyLLASLPAGRLIDRFGYKRGLLLGLLLMALGLLLFALAPSYPLL 99

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489958967 303 YLWQALAGFSFGMAFAAfMSLSVVNTSSDEQSTRMGLFQTIYSCGMFVGPVMMGVMMQH---INLSSGYILIAALSVVAA 379
Cdd:COG0738  100 LLALFLLGLGLGLLDVA-ANPYVAALGPETAASRLNLLHAFFSLGALLGPLLGGLLILLglsLSWHLPYLILAVLLLLLA 178


                 ..
gi 489958967 380 IA 381
Cdd:COG0738  179 LL 180
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
212-381 2.80e-08

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 55.27  E-value: 2.80e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489958967 212 WLIGILATVVILVPFATRDT---LTPVYAEQLGARAGILALLGNIHLLFYGLAiALCSSVFYQRLGLVKTAVLGIVLQVI 288
Cdd:COG2223    4 WRVLLLATLAFFLAFGVWYLwsvLAPPLAEEFGLSAAQLGLLFAIPVLVGALL-RIPLGFLVDRFGPRRVLLIGLLLLGI 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489958967 289 STFGIPFTSNIYVIYLWQALAGFSFGMAFAAFMSLSVVNTSSDEQSTRMGLFQTIYSCGMFVGPVMMGVMMQHINLSSGY 368
Cdd:COG2223   83 GLLLLALAVSYWLLLLLGLLLGIGGGGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGWRNAF 162

                        170
                 ....*....|...
gi 489958967 369 ILIAALSVVAAIA 381
Cdd:COG2223  163 LILGILLLVVAVL 175
MFS_ExuT_GudP_like cd17319
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ...
 32-382 7.92e-08

Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340877 [Multi-domain]  Cd Length: 358  Bit Score: 53.73  E-value: 7.92e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489958967  32 LAPMMINQGIEPQIMGIIMGASGLATLLIRFPLGIISDVVKSRRIFIQIGLLLPIIAWPIAWLePNAITLYLAKAADGVT 111
Cdd:cd17319   26 APTIMKDLGLSPTQYGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSLFTALTGFA-TSLTSLYVLRFLLGVA 104

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489958967 112 -AATWVLYNILFMRYFGRNEAPAAVALLALAGPIGVFLGNCIGAVLIHYFANNIAFFVSCISALVALILTTRIQdvhdpv 190
Cdd:cd17319  105 eAGFFPGAIKALAEWFPARERGRATGLFNSGAPLGAAIGPPLSGWLLLLFGWRWAFIIEGLLGLLLAVLWWFYL------ 178

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489958967 191 qaptlkacitgarqqladRSVWLIgILATVVILVPFATRDTLTPVYAEQLG----ARAGILALLGNIHLLFYGLAIALCS 266
Cdd:cd17319  179 ------------------RQVWGL-ALGYFGINYALYGLLTWLPTYLKQARgfslKQVGLLAAIPFLAGAIGMILGGRLS 239

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489958967 267 SVFYqRLGLVKTAVLGIVLQVISTFGIPFTSNIYVIYLWQALAGFSFGMAFAAFMSLSVVNTSSDEQSTRMGLFQTIYSC 346
Cdd:cd17319  240 DRLL-RGARRLVIIIGLLLAAVGLLLAYLTTSPVVAVILLSLAGFGIGAASPVFWSLPADLLPGEAAATAGGLINSGGNL 318

                        330       340       350
                 ....*....|....*....|....*....|....*..
gi 489958967 347 GMFVGPVMMGVMMQH-INLSSGYILIAALSVVAAIAT 382
Cdd:cd17319  319 GGFVAPLLIGYLVDAtGSYTAAFLFLAAVALLAALLV 355
FucP COG0738
Fucose permease [Carbohydrate transport and metabolism];
46-387 1.34e-07

Fucose permease [Carbohydrate transport and metabolism];


Pssm-ID: 440501 [Multi-domain]  Cd Length: 391  Bit Score: 53.32  E-value: 1.34e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489958967  46 MGIIMGASGLATLLIRFPLGIISDVVKSRRIFIqIGLLLPIIAWPIAWLEPNAITLYLAKAADGVTAATW-VLYNILFMR 124
Cdd:COG0738   45 AGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLL-LGLLLMALGLLLFALAPSYPLLLLALFLLGLGLGLLdVAANPYVAA 123

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489958967 125 YFGRNEAPAAVALLALAGpIGVFLGNCIGAVLIHYFAN---NIAFFVSCISALVALILTTRIQDVHDPVQAPTLKACITG 201
Cdd:COG0738  124 LGPETAASRLNLLHAFFS-LGALLGPLLGGLLILLGLSlswHLPYLILAVLLLLLALLFLRSKLPEIEEEEEEAAGSAAS 202

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489958967 202 ARQQLADRSVWLIGILATVVILVPFATRDTLTPVYAEQLGARAGILALLgnihLLFYGLAIA---LCSSVFYQRLGLVKT 278
Cdd:COG0738  203 LKSLLKNPRLLLGGLAIFLYVGAEGAIGDWLPLYLKDVLGLSEATAALG----LSLFWGGMTigrFLGGFLLKRFGPVRL 278

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489958967 279 AVLGIVLQVISTFGIPFTSNIYVIYLWQALAGFSFGMAFAAFMSLsVVNTSSDEQSTRMGLFQTIYSCGMFVGPVMMGVM 358
Cdd:COG0738  279 LRLSALLAAVGLLLALLAPGPWLALIGLALVGLGLSLMFPTIFSL-ALDGLGKRTAAAVSAVLIMGIVGGAIGPPLIGFL 357

                        330       340
                 ....*....|....*....|....*....
gi 489958967 359 MQHINLSSGYILIAALSVVAAIATPLSAR 387
Cdd:COG0738  358 ADAFGLRAAFLVPLVCYLLILLLALALKR 386
CynX COG2807
Cyanate permease [Inorganic ion transport and metabolism];
25-387 3.82e-07

Cyanate permease [Inorganic ion transport and metabolism];


Pssm-ID: 442057 [Multi-domain]  Cd Length: 399  Bit Score: 51.80  E-value: 3.82e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489958967  25 IHSIDAFLAPMMINQGIEPQIMGIIMGASGLATLLIRFPLGIISDVVKSRRIfIQIGLLLPIIAWPIAWLEPNAITLYLA 104
Cdd:COG2807   34 ITSVGPLLPEIRADLGLSATQAGLLTTLPLLAFGLFAPLAPRLARRFGLERT-LLLALLLLAAGLLLRSLAPSVALLLAG 112

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489958967 105 KAADGV-TAATWVLYNILFMRYFGRNeAPAAVALLALAGPIGVFLGNCIGAVLIHYFANNIAFFVSCISALVALILTTRI 183
Cdd:COG2807  113 TALIGAgIAVGNVLLPGLIKRWFPDR-VGLMTGLYTAAMGLGAALAAGLTVPLAAALGWRGALAVWALLALLALLLWLPL 191

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489958967 184 qdVHDPVQAPTLKACITGARQQLADRSVWLIGILATVVILVpFATRDTLTPVYAEQLG---ARAGILALLgnihLLFYGL 260
Cdd:COG2807  192 --LRRRPAAAAAAPAAASLRSLWRSPLAWLLTLFFGLQSLL-YYAVVAWLPPILRDAGlsaATAGLLLSL----FQLAGI 264

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489958967 261 AIALCSSVFYQRLGLVKTAVLGI-VLQVISTFGIPFTSNIyVIYLWQALAGFSFGMAFAAFMSLSVVNTSSDEQSTR-MG 338
Cdd:COG2807  265 PGSLLVPLLADRLGDRRPLLLLLgLLGLAGLLGLLLAPGS-LPWLWAVLLGLGQGGLFPLALTLIGLRARTPAEAAAlSG 343

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|
gi 489958967 339 LFQTIYSCGMFVGPVMMGVMMQHI-NLSSGYILIAALSVVAAIATPLSAR 387
Cdd:COG2807  344 MAQSVGYLLAALGPLLVGALHDATgSWTAALLLLAALAVLMLVAGLLAGR 393
MFS_YcaD_like cd17477
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ...
 257-402 1.37e-06

YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341030 [Multi-domain]  Cd Length: 360  Bit Score: 49.86  E-value: 1.37e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489958967 257 FYGLAIALCSSVFYQ---RLGLVKTAVLGIVLQVISTFGIPFTSNIYVIYLWQALAGFSFGMAFAAFMSLSVVNTSSDEQ 333
Cdd:cd17477   39 AYYLGILLGSPLVPRlirRVGHIRAFAAGAAITAVSVLLLALTDSPWVWFLLRFVMGIGLAGLFVVSESWLNALATNENR 118

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 489958967 334 STRMGLFQTIYSCGMFVGPVMMGVMMQHINLSsgYILIAALSVVAAIATPLSARWVYARKSQTSAQLLK 402
Cdd:cd17477  119 GRVLGLYSTVLGLGFALGPLLLALVGTAGALP--FLIAAVLLLLALVPLLLTRRAAPEIEEAESISLRR 185
MFS_NepI_like cd17324
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ...
 40-382 1.83e-06

Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340882 [Multi-domain]  Cd Length: 370  Bit Score: 49.47  E-value: 1.83e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489958967  40 GIEPQIMGIIMGASGLATLLIRFPLGIISDVVKSRRIFIqIGLLLPIIAWPIAWLEPNAITLYLAKAADGVTAAT-WVLY 118
Cdd:cd17324   30 GVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLL-VLLLLFILGNLLAALAPSFALLLLARALAGLAHGGfWAIA 108

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489958967 119 NILFMRYFGRNEAPAAVALLALAGPIGVFLGNCIGAVLIHYFANNIAFFVSCISALVALILTTRIQDvHDPVQAPTLKAC 198
Cdd:cd17324  109 AAYAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLGWRAAFLAIAVLALLAALLLWRLLP-SLPPKKPGSLGL 187

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489958967 199 ITGARQQLADRSVWLIGILATVVILVPFATRDTLTPVYAEQLGARAGILALLgnihLLFYGLAIALCSSVF---YQRLGL 275
Cdd:cd17324  188 LSSLLLLLRNPRLRLAYLITFLLFGGFFALYTYLAPFLTDVPGFSSSAIIGL----LLLFGVAGVVGSPLAgrlADRGGR 263

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489958967 276 VKTAVLGIVLQVISTFGIPFTSNIYVIYLWQALAGFSFGMAFAAFMSLsVVNTSSDEQSTRMGLFQTIYSCGMFVGPVMM 355
Cdd:cd17324  264 RALLIALLLLAAALLLLTLLGPSPLLLLVGLVLWGLGFFAAHSALQTR-VLRLAPEARGLASSLYLAAYNLGGALGAALG 342

                        330       340
                 ....*....|....*....|....*..
gi 489958967 356 GVMMQHINLSSGYILIAALSVVAAIAT 382
Cdd:cd17324  343 GLVLDHGGWAGVGWVGAALLLLALLLA 369
MFS_MdtH_MDR_like cd17329
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ...
 144-380 3.30e-06

Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340887 [Multi-domain]  Cd Length: 376  Bit Score: 48.76  E-value: 3.30e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489958967 144 IGVFLGNCIGAVLIHYFANNIAFFVSCISALVALILTTRIQDVHDPVQAPTLKACITGARQQLADRSVWLIgILATVVIL 223
Cdd:cd17329  135 LGVAIGPLLGGLLLLYSFRLLFLAAAVLFLLAALVLLFLLPETRPKRRAAEKTEILRGYKIVLRDRAFLLF-LLASFLIS 213

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489958967 224 VPFATRDTLTPVYAEQLGAraGILALLGNIHLLFYGLAIALCSSV--FYQRLGLVKTAVLGIVLQVISTFGIPFTSNIYV 301
Cdd:cd17329  214 LIYFQLESTLPVYVVEILG--LGESLLGLLLALNALLIVLLQFPVarLVERFRLRKILMIGILLFAIGFAVLAFANTLAV 291

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489958967 302 IYLwqALAGFSFGMAFAAFMSLSVVNTSSDEQSTR--MGLFQTIYSCGMFVGPVMMGVMMQHINLSSGYILIAALSVVAA 379
Cdd:cd17329  292 LIL--AMIVLTLGEMLVFPAVQTLVAALAPPDKRGsyMGFYALAWGLGRAIGPLVGGLLLDLLGPGLPWLILAALGLIAA 369


                 .
gi 489958967 380 I 380
Cdd:cd17329  370 A 370
MFS_arabinose_efflux_permease_like cd17473
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ...
 209-382 7.43e-06

Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341026 [Multi-domain]  Cd Length: 374  Bit Score: 47.57  E-value: 7.43e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489958967 209 RSVWLIGILATVVILVPFATRdTLTPVYAEQLG----ARAGILALLGNIhllfYGLAIALCSSVFYQRLGLVKTAVLGIV 284
Cdd:cd17473  197 KRVLPIYFLAFLAMLLFYVIP-IQLPFLLQERGggsaALIGLALAIASL----AGAIGALLFGRLKRRLGKRRLLAIGFA 271

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489958967 285 LQVISTFGIPFTSNIYVIYLWQALAGFSFGMAFAAFMSLsVVNTSSDEQSTR-MGLFQTIYSCGMFVGPVMMGVMMQHI- 362
Cdd:cd17473  272 LMALGFLLLALASGLWVVLLGAILAGLGFGLLLPTLNSW-AMSLVPPELRGRaMGIVTSAFFLGQFLSPLVLGPLVNLTg 350

                        170       180
                 ....*....|....*....|
gi 489958967 363 NLSSGYILIAALSVVAAIAT 382
Cdd:cd17473  351 GLSGAFLILGVLALVLAIVL 370
CynX COG2807
Cyanate permease [Inorganic ion transport and metabolism];
209-387 1.22e-05

Cyanate permease [Inorganic ion transport and metabolism];


Pssm-ID: 442057 [Multi-domain]  Cd Length: 399  Bit Score: 47.18  E-value: 1.22e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489958967 209 RSVWLIGILATVVIL-VPFATRDTLTPVYAEQLGARAGILALLGNIHLLFYGLAiALCSSVFYQRLGLVKTAVLGIVLQV 287
Cdd:COG2807   16 RWLLLLAIVLVALNLrPAITSVGPLLPEIRADLGLSATQAGLLTTLPLLAFGLF-APLAPRLARRFGLERTLLLALLLLA 94

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489958967 288 ISTFGIPFTSNIYVIYLWQALAGFSFGMAFAAFMSLsVVNTSSDEQSTRMGLFQTIYSCGMFVGPVMMGVMMQHINLSSG 367
Cdd:COG2807   95 AGLLLRSLAPSVALLLAGTALIGAGIAVGNVLLPGL-IKRWFPDRVGLMTGLYTAAMGLGAALAAGLTVPLAAALGWRGA 173

                        170       180
                 ....*....|....*....|
gi 489958967 368 YILIAALSVVAAIATPLSAR 387
Cdd:COG2807  174 LAVWALLALLALLLWLPLLR 193
MFS_OFA_like cd17353
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ...
 145-382 2.57e-05

Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340911 [Multi-domain]  Cd Length: 389  Bit Score: 46.06  E-value: 2.57e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489958967 145 GVFLGNCIGAVLIHYFANNIAFFV-SCISALVALILTTRIQDVHDPVQAPTLKACITGARQQLADRSV------------ 211
Cdd:cd17353  139 GSLIFSPLIAYLINTVGVPTTFLIlGIIFLIIIVIGAFLIRDPPKGWVPPGVDPLANNAENSPRDYTPremlrtptfwll 218

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489958967 212 WLIGILATVVILVPFATrdtLTPVYAEQLGARAGILALLGNIHLLFYGLAIALCSSVfYQRLGLVKTAVLGIVLQVISTF 291
Cdd:cd17353  219 WLMFFLNATAGLMLIGQ---AKPIGQEFAGLDAGIAALAVSILSIFNGGGRPFWGWL-SDKIGRKNTLSIAFLIQGVAMF 294

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489958967 292 GIPFTSNIYVIY-LWQALAGFSFGMAFAAFMSLSVVNTSSDEQSTRMGLFQTIYSCGMFVGPVMMGVMMQHINLSSGYIL 370
Cdd:cd17353  295 LLPFIGSVAVLFvLGVALIGFCYGGGFALFPALTADFFGTKNAGTNYGLLYTAKGVGGLIGPIIAAYVLYTGGYNAAFII 374

                        250
                 ....*....|..
gi 489958967 371 IAALSVVAAIAT 382
Cdd:cd17353  375 AAALSLVALALA 386
ProP COG0477
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ...
 209-384 2.83e-05

MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];


Pssm-ID: 440245 [Multi-domain]  Cd Length: 295  Bit Score: 45.57  E-value: 2.83e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489958967 209 RSVWLIGILATVVILVPFATRDTLTPVYAEQLGARAGILALLGNIHLLFYGLAiALCSSVFYQRLGLVKTAVLGIVLQVI 288
Cdd:COG0477   13 RRALLALALGTFLEGLDFTIVNVALPSIAADLGASSAQLGWIVSAYLLGRAIG-LLLFGRLGDRYGRKRVLLIGLLLFGL 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489958967 289 STFGIPFTSNIYVIYLWQALAGFSFGMAFAAFMSLSVVNTSSDEQSTRMGLFQTIYSCGMFVGPVMMGVMMQHINLSSGY 368
Cdd:COG0477   92 ASLLCGLAPSPELLIAARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLVAALGWRWIF 171

                        170
                 ....*....|....*.
gi 489958967 369 ILIAALSVVAAIATPL 384
Cdd:COG0477  172 LINAPLGLLALVLRLR 187
MFS_FucP_MFSD4_like cd17333
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ...
 247-410 3.20e-05

Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340891 [Multi-domain]  Cd Length: 372  Bit Score: 45.78  E-value: 3.20e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489958967 247 LALLGNIHLLFYG--LAIALCSSVFYQRLGLVKTAVLGIVLQVISTFGIPFTSNIYVIYLWQALAGFSFGmAFAAFMSLS 324
Cdd:cd17333   30 VADVSVIFSSQNAgyLIGSLLAGFLMKRLGRRRTLILGLLLISLALALIFATPSIYLFVVLMFLAGLGAG-ILDTGANTF 108

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489958967 325 VVNTSSDEQSTRMGLFQTIYSCGMFVGPVMMGVMMQHINLSSGYILIAALSVVAAIATPLSARWVYARKSQTSAQLLKNG 404
Cdd:cd17333  109 VGALFEESSATRLNVLHGFFGLGALIGPLIATSLLTSELSWSWAYLIIGLIYLLLAILILLTLFPELPSARNPQQSVGAF 188


                 ....*.
gi 489958967 405 AYAAAP 410
Cdd:cd17333  189 SASASR 194
MFS_SLC18B1 cd17385
Solute carrier family 18 member B1 of the Major Facilitator Superfamily of transporters; ...
 144-384 3.82e-05

Solute carrier family 18 member B1 of the Major Facilitator Superfamily of transporters; Solute carrier family 18 member B1 (SLC18B1) is the fourth member of the SLC18 transporter family, which includes vesicular monoamine transporters and vesicular acetylcholine transporter. It is predominantly expressed in the hippocampus and is associated with vesicles in astrocytes. It actively transports spermine and spermidine by exchange of H(+), and has been suggested to be a vesicular polyamine transporter (VPAT). SLC18B1 belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340943 [Multi-domain]  Cd Length: 390  Bit Score: 45.67  E-value: 3.82e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489958967 144 IGVFLGNCIGAVLIHYFANNIAFFVSCISALVALILTTRIQDVHDPVQAPTLKacitGARQQLADRSVWLIGiLATVVIL 223
Cdd:cd17385  140 LGLMLGPPLGGFLYQAGGYELPFLVLGCLLLLTVPLNMFILPRYDDDPSPKSG----SMLKLLKIPSVLLLC-LSIVSGS 214

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489958967 224 VPFATRD-TLTPvYAEQLGARAGILALLGNIHLLFYGLAI----ALCSSVFYQRLglvkTAVLGIVLQVISTFGI----- 293
Cdd:cd17385  215 VSLGFLDpTLSP-HLRQFKLSPGQVGLMFLILAGSYAISAplwgWLSDKKKIPKW----LMVIGSIITGVGFLLLgpapl 289

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489958967 294 -PFTSNIYVIYLWQALAGFSFGMA----FAAFMSLSVVNTSSDEQSTR---MGLFQTIYSCGMFVGPVMMGVMMQHINLS 365
Cdd:cd17385  290 lPIKSELWMVIIGLVLLGLSLGAAlvptFPELLNCAREYGFPDNLSTYglvSGLFNAAFSLGAFIGPTLGGFLLERLGFE 369

                        250
                 ....*....|....*....
gi 489958967 366 SGYILIAALSVVAAIATPL 384
Cdd:cd17385  370 WAATIQAGLAFVVGILMSI 388
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 217-384 6.31e-05

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 44.72  E-value: 6.31e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489958967 217 LATVVILVPFATRDTLTPVYAEQLGARAGILALLGNIHLLFYGLAIALCSsVFYQRLGLVKTAVLGIVLQVISTFGIPFT 296
Cdd:cd06174    3 LGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAG-LLADRFGRRPVLLLGLLLFALGALLFAFA 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489958967 297 SNIYVIYLWQALAGFSFGMAFAAFMSLSVVNTSSDEQSTRMGLFQTIYSCGMFVGPVMMGVMMQHINLS--SGYILIAAL 374
Cdd:cd06174   82 PSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSLGFGwrAVFLIAAAL 161

                        170
                 ....*....|
gi 489958967 375 SVVAAIATPL 384
Cdd:cd06174  162 ALLAAILLLL 171
MFS_SLC45_SUC cd17313
Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily ...
 30-381 1.35e-04

Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily of transporters; This group includes the solute carrier 45 (SLC45) family as well as plant sucrose transporters (SUCs or SUTs) and similar proteins such as Schizosaccharomyces pombe general alpha-glucoside permease. the SLC45 family is composed of four (A1-A4) vertebrate proteins as well as related insect proteins such as Drosophila sucrose transporter SCRT or Slc45-1. Members of this group transport sucrose and other sugars like maltose into the cell, with the concomitant uptake of protons (symport system). Plant sucrose transporters are crucial to carbon partitioning, playing a key role in phloem loading/unloading. They play a key role in loading and unloading of sucrose into the phloem and as a result, they control sucrose distribution throughout the whole plant and drive the osmotic flow system in the phloem. They also play a role in the exchange of sucrose between beneficial symbionts (mycorrhiza and Rhizobium) as well as pathogens such as nematodes and parasitic fungi. There are nine sucrose transporter genes in Arabidopsis and five in rice. Vertebrate SLC45 family proteins have been implicated in the regulation of glucose homoeostasis in the brain (SLC45A1), with skin and hair pigmentation (SLC45A2), and with prostate cancer and myelination (SLC45A3). Mutations in SLC45A2, also called MATP (membrane-associated transporter protein) or melanoma antigen AIM1, cause oculocutaneous albinism type 4 (OCA4), an autosomal recessive disorder of melanin biosynthesis that results in congenital hypopigmentation of ocular and cutaneous tissues. The SLC45 family and related sugar transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340871 [Multi-domain]  Cd Length: 421  Bit Score: 43.77  E-value: 1.35e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489958967  30 AFLAPMMINQGIEPQIMGIIMGASGLATLLIRFPLGIISDVVKS----RRIFIQIGLLLPIIAwpiAWLEPNAITLYLA- 104
Cdd:cd17313   20 SYVPPILQTLGLSHALIGFVWTLGPILGLFVQPLVGSLSDRCNSrigrRRPFILVGAPLAALG---LILIPNAADIGLAl 96

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489958967 105 -----KAADGVTAATWVLYNI-----------LFMRYFGRNEAPAAVALLALAGPIGVFLGNCIGAVL-------IHYFA 161
Cdd:cd17313   97 gdgprTWALVLFVLGIVLLDFamnvcqgpvraLLPDLVPPEQRSKANGIINFMGGLGGVLGYLLGAILwdhnwfgFALGG 176

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489958967 162 NN-IAFFVSCISALVALILT-TRIQDVHDPVQAPTlKACITGARQQL---------ADRSVW--LIGILATVVILVPFAT 228
Cdd:cd17313  177 NLkVPFYIGAIILLVCVLVTlFFVKEPPLSPEAGE-HSENPSLGEVLksllkllkiMPRSLLrlLLVIFFWWIAFFPFEL 255

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489958967 229 RDTLtpvYAEQLGARAGILALL--------GNIHLLFYGLAIALCSSV---FYQRLGLVKTAVLGIVLQVISTFGIPFTS 297
Cdd:cd17313  256 FFTD---YMGEEVYHGTSAASShygagvrmGAWGLLIFSLAFLIFSLPigkLGKKIGRKKVYLIGLVLFAVGMALMALVH 332

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489958967 298 NIYVIYLWQALAGFSFGMAFAafMSLSVVNTSSDEQSTRMGLFQTIYSCGMF----VGPVMMGVMMQHINLSSGYILIAA 373
Cdd:cd17313  333 NVTVALVLFALGGIGWATINI--NPYPLVSDYHSESGRGQGTDTGLLNLAISlaqiLVSLLAGPIIDVKGYGTVFPVAAV 410


                 ....*...
gi 489958967 374 LSVVAAIA 381
Cdd:cd17313  411 ASFLSLVG 418
ProP COG0477
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ...
 40-290 2.34e-04

MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];


Pssm-ID: 440245 [Multi-domain]  Cd Length: 295  Bit Score: 42.88  E-value: 2.34e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489958967  40 GIEPQIMGIIMGASGLATLLIRFPLGIISDVVKSRRIFIqIGLLLPIIAWPIAWLEPNAITLYLAKAADGVTAAT-WVLY 118
Cdd:COG0477   45 GASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLL-IGLLLFGLASLLCGLAPSPELLIAARALQGIGAGGlMPGA 123

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489958967 119 NILFMRYFGRNEAPAAVALLALAGPIGVFLGNCIGAVLIHYFANNIAFFVSCISALVALILTTRIQDVHDPVQAPTLKAC 198
Cdd:COG0477  124 LALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLVAALGWRWIFLINAPLGLLALVLRLRLPESRGLLLALLALAL 203

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489958967 199 ITGARQQLADRSVWLIGILATVVILVPFATRDTLTPVYAEQLGARAGILALLGNIHLLFYGLAIALCSSVFYQRLGLVKT 278
Cdd:COG0477  204 AALLLAALALALLALLLLLLLLLLALLALLLAGAALLLLLALLLLALLLLLALLLLAALLLLLLLLLLLALLLALLLLLL 283

                        250
                 ....*....|..
gi 489958967 279 AVLGIVLQVIST 290
Cdd:COG0477  284 LLLLLLLLALLL 295
MFS_MFSD6 cd17335
Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily ...
 163-381 2.57e-04

Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily domain-containing protein 6 (MFSD6) is also called macrophage MHC class I receptor 2 homolog (MMR2). It has been postulated as a possible receptor for human leukocyte antigen (HLA)-B62. MFSD6 is conserved through evolution and appeared before bilateral animals. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340893 [Multi-domain]  Cd Length: 375  Bit Score: 42.96  E-value: 2.57e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489958967 163 NIAFFVSCISALVALILTTRIQdVHDPVQAPTLKAciTGARQQLADRSVWLIgILATVVILVPFATRDTLTPVYAEQLGA 242
Cdd:cd17335  155 TIAFYVFAVLMLLALLLALKFP-FRPKHPEPNENT--GGLLALLRNPRVLAF-LLVAFLMGFGHGLIYSFLFWHLQDLGG 230

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489958967 243 RA---GILALLGNIHllfyGLAIALCSSVFYQRLGLVKTAVLGIVLQVISTFGIPFTSNIYVIYLWQALAGFSFGMAFAA 319
Cdd:cd17335  231 SKtliGLLWTVGVVS----EIPFFFFSSRLIQRFGHVGLLYLGLLAYVVRWLLYSFLENPWLVLPIELLHGLTFALVWAA 306

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 489958967 320 FMSLSVVNTSSDEQSTRMGLFQTIY-----SCGMFVGpvmmGVMMQHINLSSGYILIAALSVVAAIA 381
Cdd:cd17335  307 AVSYASAAAPPGLRATAQGLLQGLYfglggGLGSLIG----GYLYEAFGARTTFRFFAIAALAGLLA 369
MFS_YajR_like cd17472
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux ...
 47-377 4.59e-04

Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli inner membrane transport protein YajR and some uncharacterized multidrug-efflux transporters. YajR is a putative proton-driven major facilitator superfamily (MFS) transporter found in many gram-negative bacteria. Unlike most MFS transporters, YajR contains a C-terminal, cytosolic YAM domain, which may play an essential role for the proper functioning of the transporter. YajR-like transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341025 [Multi-domain]  Cd Length: 371  Bit Score: 42.20  E-value: 4.59e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489958967  47 GIIMGASGLATLLIRFPLGIISDVVkSRRIFIQIGLLLPIIAWPIAWLEPNAITLYLAKAADGVTAATWVLynILFMRYF 126
Cdd:cd17472   35 GLALGIYGLTQAIFQIPFGLLSDRI-GRKPVILFGLLLFIAGSLLAAYATSIYGLILGRALQGSGAISSVV--MALLADL 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489958967 127 GRNEAPAAVALLALAgPIGVF--LGNCIGAVLIHYFANNIAFFVSCISALVALILTTRiqdVHDPVQAPTLKACITGA-- 202
Cdd:cd17472  112 TREENRTKAMALIGA-SIGIAfaISMVLGPLLAAHLGVSGLFLITAILSLVSLLILLF---FVPDPPKIVQISEKEKKkl 187

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489958967 203 RQQLADRSVWLIGILATVVILVPFATRdTLTPVYAEQLGaragiLALLGNIHLLFYGLAIALCSSVFYQRLGLVKTAVLG 282
Cdd:cd17472  188 KKLLKNKRLLRLDFSIFILHFVLMAFF-YILPLLLTQLG-----GGKGQLWKVYLPAILIGFILMVPFVIYAEKKGKMKQ 261

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489958967 283 IVLQVISTFGIPF-TSNIYVIYLWQALAGFSFgmAFAAFMSLSVVNTS-------SDEQSTRMGLFQTIYSCGMFVGPVM 354
Cdd:cd17472  262 VFVSSILLIAVGFlLLLFAATSLWLLIIGLII--FFIGFNLLEALLPSlvskiapKEYRGTAMGIYNTSQFLGSFLGGAL 339

                        330       340
                 ....*....|....*....|...
gi 489958967 355 MGVMMQHINLSSGYILIAALSVV 377
Cdd:cd17472  340 GGLLWGLLGYSSVFLTILILALL 362
MFS_NepI_like cd17324
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ...
 211-409 4.97e-04

Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340882 [Multi-domain]  Cd Length: 370  Bit Score: 41.77  E-value: 4.97e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489958967 211 VWLIGILATVVILVPFATrDTLTPVYAEQLGARAGILALLGNIHLLFYGLAiALCSSVFYQRLGLVKTAVLGIVLQVIST 290
Cdd:cd17324    1 LLALALAAFAIGTTEYVI-QGLLPDIARDFGVSVAQAGLLVSAYALGYALG-ALLLGPLSDRIERRRLLLVLLLLFILGN 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489958967 291 FGIPFTSNIYVIYLWQALAGFSFGMAFAAFMSLSVVNTSSDEQSTRMGLFQTIYSCGMFVGPVMMGVMMQHINLSSGYIL 370
Cdd:cd17324   79 LLAALAPSFALLLLARALAGLAHGGFWAIAAAYAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLGWRAAFLA 158

                        170       180       190
                 ....*....|....*....|....*....|....*....
gi 489958967 371 IAALSVVAAIATplsARWVYARKSQTSAQLLKNGAYAAA 409
Cdd:cd17324  159 IAVLALLAALLL---WRLLPSLPPKKPGSLGLLSSLLLL 194
MFS_MelB_like cd17332
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major ...
 40-323 7.43e-04

Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major Facilitator Superfamily; This family is composed of Salmonella enterica Na+/melibiose symporter MelB, Major Facilitator Superfamily domain-containing proteins, MFSD2 and MFSD12, and other sugar transporters. MelB catalyzes the electrogenic symport of galactosides with Na+, Li+ or H+. The MFSD2 subfamily is composed of two vertebrate members, MFSD2A and MFSD2B. MFSD2A is more commonly called sodium-dependent lysophosphatidylcholine symporter 1 (NLS1). It is an LPC symporter that plays an essential role for blood-brain barrier formation and function. Inactivating mutations in MFSD2A cause a lethal microcephaly syndrome. MFSD2B is a potential risk or protect factor in the prognosis of lung adenocarcinoma. MelB-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340890 [Multi-domain]  Cd Length: 424  Bit Score: 41.44  E-value: 7.43e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489958967  40 GIEPQIMGIIMGASGLATLLIRFPLGIISDVVKSR----RIFIQIGLLLPIIAWPIAWLEPN---------AITLYLakA 106
Cdd:cd17332   31 GLSAAAAGTIFLVARIIDAINDPLMGYLIDRTRSRwgrfRPWLLWGAIPLALLFVLLFTTPDgsgtgkliyALITYI--L 108

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489958967 107 ADGVTAATWVLYNILFMRYFGR-NEAPAAVALLALAGPIGVFLGNCIGAVLIHYFAN--------NIAFFVSCISALVAL 177
Cdd:cd17332  109 LDLLYTLVNIPYTALIPELTDDpEERTSLTSWRMFFATIGGLLVTVLPPPLVAYFGGgnasrgyfLTALIIGIIGIILLL 188

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489958967 178 ILTTRIQDVHDPVQAPTLKACITGARQQLADRSVWLIGILATVVILVPFATRDTLTPVYAEQLGARAGILALLGNIHLLF 257
Cdd:cd17332  189 ICFFGTRERVVPPEEEKSKLPLLKSLKALLKNRPFLILLLAYLLYFLAFNIVNTVLVYYFKYVLGGRAELVLLLLLILSG 268

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 489958967 258 YGLAIALcSSVFYQRLGLVKTAVLGIVLQVISTFGIPFTS--NIYVIYLWQALAGFSFGMAFAAFMSL 323
Cdd:cd17332  269 ALLALLP-WPPLKKRFGKKKAFFIGLLLAILGLLLLFFLPpgNLVLILVLAVLAGIGYGGANLLPWAM 335
MFS_CsbX cd17337
CsbX family of the Major Facilitator Superfamily of transporters; The CsbX family is composed ...
 257-381 7.93e-04

CsbX family of the Major Facilitator Superfamily of transporters; The CsbX family is composed of Bacillus subtilis CsbX protein (also named alpha-ketoglutarate permease), Klebsiella pneumoniae D-arabinitol transporter (DalT), and similar proteins. The csbX gene is a sigmaB-controlled gene that is expressed during the stationary phase of cell growth. DalT is a pentose-specific ion symporter for D-arabinitol uptake. Most members of this family remain uncharacterized. The CsbX family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340895 [Multi-domain]  Cd Length: 388  Bit Score: 41.33  E-value: 7.93e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489958967 257 FYGLAIAL---CSSVFYQRLGLVKTAVLGIVLQVIS-----TFGIPfTSNIYVIYLWQALAGFSFGMAFAAFMSLSVVNT 328
Cdd:cd17337   40 VYGLTVAIaswLSGVLAELFGPRRVMLIGLIIWLVFevlflAFGLP-SHNYPLMLLTYGLRGFGYPLFAYSFLVWITYRT 118

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 489958967 329 SSDEQSTRMGLFQTIYSCGM-FVGPVMMGVMMQHInlssGYILIAALSVVAAIA 381
Cdd:cd17337  119 PAERLGSAVGWFWFAFTGGLpVLGSYLASFTIPVI----GEIGTLWLSLVFVAL 168
MFS_MCT_SLC16 cd17352
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; ...
 236-381 1.66e-03

Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; The animal Monocarboxylate transporter (MCT) family is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCT1-4 are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT8 and MCT10 are transporters which stimulate the cellular uptake of thyroid hormones such as thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). MCT10 also functions as a sodium-independent transporter that mediates the uptake or efflux of aromatic acids. Many members are orphan transporters whose substrates are yet to be determined. The MCT family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340910 [Multi-domain]  Cd Length: 361  Bit Score: 40.23  E-value: 1.66e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489958967 236 YAEQLGARAGILALLGNIhLLFYGLAIALCSSVFYQRLGLVKTAVLGIVLQVISTFGIPFTSNIYVIYLWQA-LAGFSFG 314
Cdd:cd17352   29 LLEEFGESTSDIAWIGSL-LLGVSLFSGPLSSALVNRFGCRPVAIAGGLLAALGLLLSSFATSLWQLYLTYGvLGGLGLG 107

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 489958967 315 MAFAAfmSLSVVNTS-SDEQSTRMGLFQTIYSCGMFVGPVMMGVMMQHINLSSGYILIAALSVVAAIA 381
Cdd:cd17352  108 LIYSP--AIVIVGQYfEKKRGLATGIAVAGSGVGTFVFPPLLRYLLDNYGWRGALLILGGLCLNLCVC 173
MFS_MMR_MDR_like cd17321
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ...
 63-359 1.82e-03

Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340879 [Multi-domain]  Cd Length: 370  Bit Score: 40.23  E-value: 1.82e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489958967  63 PLGIISDVVKSRRIFIqIGLLLPIIAWPIAWLEPNAITLYLAKAADGVTAATWVLYNI-LFMRYFGRNEAPAAVALLALA 141
Cdd:cd17321   50 LAGRLGDRFGRKRVFL-IGLALFGLASLLCALAPSLAFLIAARALQGIGAAAIMPASLaLIAATFPGERRGRALGLWGAV 128

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489958967 142 GPIGVFLGNCIGAVLIHYFANNIAFFVSCISALVALILTTRIqdvhdpvqaptlkacitgarqqladrSVWLIGILATVV 221
Cdd:cd17321  129 VGIGAALGPLLGGLLLELFGWRWIFLINVPIGLVALLLARTF--------------------------SGAVLAAFLLGA 182

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489958967 222 ILVPFATrdtLTPVYaeqLGARAGILALLGNIHLLFYGLAIALCSSV---FYQRLGLVKTAVLGIVLQVISTFGIPFT-- 296
Cdd:cd17321  183 ALGGLLF---LLPLY---LQGVLGYSPLQAGLALLPLALAMLVAAPLagrLADRFGPRLVLVAGLLLTAVGLLLLALLga 256

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 489958967 297 -SNIYVIYLWQALAGFSFGMAFAAFMSLSVVNTSSDEQSTRMGLFQTIYSCGMFVGPVMMGVMM 359
Cdd:cd17321  257 dSSVWLLLPGLVLLGLGLGLFATPLTNAALSSVPKEKAGAASGILNTARQLGGALGVALLGALL 320
MFS_MFSD9 cd17390
Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily ...
 284-382 1.84e-03

Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily domain-containing protein 9 (MFSD9) is expressed in the central nervous system (CNS) and in most peripheral tissues but at very low expression levels. The function of MFSD9 is unknown. MFSD9 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340948 [Multi-domain]  Cd Length: 350  Bit Score: 40.29  E-value: 1.84e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489958967 284 VLQVISTFGIPFTSNIYVIYLWQALAGFSFGMAFAAFMSLSVVNTSSDEQSTRMGLFQTIYSCGMFVGPVMMGVMMQhIN 363
Cdd:cd17390  248 ILLALSLLGLALAPSIWLLVLCLTPLSISSAVLRTCSTSLLLSRGKSKERGTLLGVGQSVTSLARILAPLLSGLLQE-FS 326

                         90
                 ....*....|....*....
gi 489958967 364 LSSGYILIAALSVVAAIAT 382
Cdd:cd17390  327 VSGPGLLGAVLALAAILLM 345
MFS_MelB_like cd17332
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major ...
 144-326 2.69e-03

Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major Facilitator Superfamily; This family is composed of Salmonella enterica Na+/melibiose symporter MelB, Major Facilitator Superfamily domain-containing proteins, MFSD2 and MFSD12, and other sugar transporters. MelB catalyzes the electrogenic symport of galactosides with Na+, Li+ or H+. The MFSD2 subfamily is composed of two vertebrate members, MFSD2A and MFSD2B. MFSD2A is more commonly called sodium-dependent lysophosphatidylcholine symporter 1 (NLS1). It is an LPC symporter that plays an essential role for blood-brain barrier formation and function. Inactivating mutations in MFSD2A cause a lethal microcephaly syndrome. MFSD2B is a potential risk or protect factor in the prognosis of lung adenocarcinoma. MelB-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340890 [Multi-domain]  Cd Length: 424  Bit Score: 39.90  E-value: 2.69e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489958967 144 IGVFLGNCIGAVLIHYFAN--------NIAFFVSCISALVALILTTRIQDVHDPVQAPTLKACITGARQQLADRSVWLIG 215
Cdd:cd17332  147 IGGLLVTVLPPPLVAYFGGgnasrgyfLTALIIGIIGIILLLICFFGTRERVVPPEEEKSKLPLLKSLKALLKNRPFLIL 226

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489958967 216 ILATVVILVPFATRDTLTPVYAEQLGARAGILALLGNIHLLFYGLAIALcSSVFYQRLGLVKTAVLGIVLQVISTFGIPF 295
Cdd:cd17332  227 LLAYLLYFLAFNIVNTVLVYYFKYVLGGRAELVLLLLLILSGALLALLP-WPPLKKRFGKKKAFFIGLLLAILGLLLLFF 305

                        170       180       190
                 ....*....|....*....|....*....|.
gi 489958967 296 TSNIYVIYLWQALAGFSFGMAFAAFMSLSVV 326
Cdd:cd17332  306 LPPGNLVLILVLAVLAGIGYGGANLLPWAML 336
MFS_MMR_MDR_like cd17504
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ...
 64-359 4.14e-03

Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341047 [Multi-domain]  Cd Length: 371  Bit Score: 39.10  E-value: 4.14e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489958967  64 LGIISDVVKSRRIFIqIGLLLPIIAWPIAWLEPNAITLYLAKAADGVTAATWVLYNILFMRYFGRNEAPAAVALLALAGP 143
Cdd:cd17504   51 LGRLGDLYGRKKVLL-IVLAIYTAGSLLAAFAPNLPVLIAGRALQGIGGAVFPLAFALVREEFPPERVPVAQGILSATFG 129

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489958967 144 IGVFLGNCIGAVLIHYFANNIAFFVSCISALVALILTTRIqdvhdpvqaptlkacitgARQQLADRSVWLIGILATVVIL 223
Cdd:cd17504  130 IGAGIGLPLGGWIVQHLGWRWIFWTAAPVAVLLAALVPLI------------------DLRLLRRRNVLLANITALLAGF 191

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489958967 224 VPFATRDTLTPVYAEQLGARAGILALLGNIHLLFYGLAIALCSSVF---YQRLGLVKTAVLGIVLQVISTFGIPFT-SNI 299
Cdd:cd17504  192 GMFMVFQLLPQLLQLPTPTGFGLGITEAGLLLLPGALVMLIAGPLAgrlIARVGPRRVLLIGLVISAVGLLLLALLhSSL 271

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 489958967 300 YVIYLWQALAGFSFGMAFAAFMSLSVVNTSSDEQSTRMGLFQTIYSCGMFVGPVMMGVMM 359
Cdd:cd17504  272 WALVVALLLIGIGLGLAFASLPNIVVESVPPDRTGIATGMNTVLRTIGSAIGPAIAGAIL 331
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 2-183 5.38e-03

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 38.71  E-value: 5.38e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489958967   2 FQALLRRREARLFFIISILFFICIHSIDAFLAPMMINQ-GIEPQIMGIIMGASGLATLLIRFPLGIISDVVkSRRIFIQI 80
Cdd:cd17325  192 LRLLLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELgGLSPAQIGLLFGAQGLASALSQPPAGKLSDRI-GRKPLILI 270

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489958967  81 GLLLPIIAWPIAWLEPNAITLYLAKAADGV-TAATWVLYNILFMRYFGRNEAPAAVALLALAGPIGVFLGNCIGAVLIHY 159
Cdd:cd17325  271 GLLLSAVALLLLPLATSFWLLLLLLALLGLgLGLVFPATLALLADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDA 350

                        170       180
                 ....*....|....*....|....
gi 489958967 160 FANNIAFFVSCISALVALILTTRI 183
Cdd:cd17325  351 FGFATPFLAAAALLLLAAVLFLLL 374
MFS_MMR_MDR_like cd17321
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ...
 234-391 6.11e-03

Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340879 [Multi-domain]  Cd Length: 370  Bit Score: 38.69  E-value: 6.11e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489958967 234 PVYAEQLGARAGILALLGNIHLLFYGLAIALCSSvFYQRLGLVKTAVLGIVLQVISTFGIPFTSNIYVIYLWQALAGFSF 313
Cdd:cd17321   20 PTIARDLGASPSQLQWVVNAYLLAFAALLLLAGR-LGDRFGRKRVFLIGLALFGLASLLCALAPSLAFLIAARALQGIGA 98

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 489958967 314 GMAFAAFMSLSVVNTSSDEQSTRMGLFQTIYSCGMFVGPVMMGVMMQHINLSSGYILIAALSVVAAIATPLSARWVYA 391
Cdd:cd17321   99 AAIMPASLALIAATFPGERRGRALGLWGAVVGIGAALGPLLGGLLLELFGWRWIFLINVPIGLVALLLARTFSGAVLA 176
MFS_MdtG_MDR_like cd17391
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ...
 145-380 7.58e-03

Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340949 [Multi-domain]  Cd Length: 380  Bit Score: 38.40  E-value: 7.58e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489958967 145 GVFLGNCIGAVLIHYFANNIAFFVSCISALVALILTtrIQDVHDPVQAPTLKACITGAR--QQLADRSVWLIGILATVVI 222
Cdd:cd17391  136 GTLIGPLLGGFLADLFGIRNVFFITGGLLFLAFLLT--LFFVKEDFKPVEKKKMVSTKEvwNSVPNPSLLISLFVTTFII 213

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489958967 223 LVPFATRDTLTPVYAEQLGARAGILALLGNIHLLFYGLAiALCSSVFYQRLG--LVKTAVLGIVLQVISTFGIP--FTSN 298
Cdd:cd17391  214 QLANQSIEPILTLYIRQLMGDASNLAFISGLVFSATGVS-SLLSAPRLGKLGdrIGHHRILLGALLASALLYIPqaFVQT 292

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489958967 299 IYVIYLWQALAGFSFGMAFAAFMSLSVVNTSSDEQSTRMGLFQTIYSCGMFVGPVMMGVMMQHINLSSGYILIAALSVVA 378
Cdd:cd17391  293 PWQLGILRFLLGLATGGLLPAINSLLAKITPKEVAGRIFGYNQSFQYLGNVAGPLLGSAIAAHFGYRAVFVVTALLVLLN 372


                 ..
gi 489958967 379 AI 380
Cdd:cd17391  373 AI 374
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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