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Conserved domains on  [gi|489954096|ref|WP_003857403|]
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MULTISPECIES: GntR family transcriptional regulator [Enterobacter]

Protein Classification

GntR family transcriptional regulator( domain architecture ID 11448455)

GntR-family transcriptional regulator is one of a group of transcriptional regulators with a conserved N-terminal helix-turn-helix DNA-binding domain and a diverse C-terminal effector-binding and oligomerization domain; controls the expression of genes with diverse biological functions

CATH:  1.10.10.10
Gene Ontology:  GO:0003700|GO:0003677
PubMed:  33509775
SCOP:  4000155

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
GntR COG1802
DNA-binding transcriptional regulator, GntR family [Transcription];
3-223 9.00e-55

DNA-binding transcriptional regulator, GntR family [Transcription];


:

Pssm-ID: 441407 [Multi-domain]  Cd Length: 222  Bit Score: 174.73  E-value: 9.00e-55
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489954096   3 AESQLNPTQPVNQQIYRILRRDIVRCLIPPGTPLSEKEVSVRFDVSRQPVREAFIKLAENGLIQIRPQRGSYVNKISLSQ 82
Cdd:COG1802    2 TSPSPLRRESLAEQVYEALREAILSGELPPGERLSEAELAERLGVSRTPVREALRRLEAEGLVEIRPNRGARVAPLSPEE 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489954096  83 VRNGCFVRQAIECAVVRRAASLINDNQCYLLEQNLHQQRIAIDRKQLNDFFQLDDEFHQKLAQIAECQLAWDTVENIKAT 162
Cdd:COG1802   82 IRELYEVRAALEGLAARLAAERATPADLARLRALLEELEAAAAAGDVAAYLELDREFHRALVEAAGNPRLAELLRRLRAR 161

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 489954096 163 IDRVRYMSLDHVSPPEMLLRQHHDIFSALEKRDVEAVDKAMTLHLQEISESVQLIRQENRE 223
Cdd:COG1802  162 LRRYRRLSLRSPGRLEESLAEHRAILDALEAGDAEAAAAALRAHLERARERLLEALAAAAA 222
 
Name Accession Description Interval E-value
GntR COG1802
DNA-binding transcriptional regulator, GntR family [Transcription];
3-223 9.00e-55

DNA-binding transcriptional regulator, GntR family [Transcription];


Pssm-ID: 441407 [Multi-domain]  Cd Length: 222  Bit Score: 174.73  E-value: 9.00e-55
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489954096   3 AESQLNPTQPVNQQIYRILRRDIVRCLIPPGTPLSEKEVSVRFDVSRQPVREAFIKLAENGLIQIRPQRGSYVNKISLSQ 82
Cdd:COG1802    2 TSPSPLRRESLAEQVYEALREAILSGELPPGERLSEAELAERLGVSRTPVREALRRLEAEGLVEIRPNRGARVAPLSPEE 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489954096  83 VRNGCFVRQAIECAVVRRAASLINDNQCYLLEQNLHQQRIAIDRKQLNDFFQLDDEFHQKLAQIAECQLAWDTVENIKAT 162
Cdd:COG1802   82 IRELYEVRAALEGLAARLAAERATPADLARLRALLEELEAAAAAGDVAAYLELDREFHRALVEAAGNPRLAELLRRLRAR 161

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 489954096 163 IDRVRYMSLDHVSPPEMLLRQHHDIFSALEKRDVEAVDKAMTLHLQEISESVQLIRQENRE 223
Cdd:COG1802  162 LRRYRRLSLRSPGRLEESLAEHRAILDALEAGDAEAAAAALRAHLERARERLLEALAAAAA 222
FCD pfam07729
FCD domain; This domain is the C-terminal ligand binding domain of many members of the GntR ...
 89-204 4.97e-21

FCD domain; This domain is the C-terminal ligand binding domain of many members of the GntR family. This domain binds to a range of effector molecules, including Lactate, Zn(II), Ni(II), Ca(II), Mg(II), citrate, sugar acids, sialic acid and N-acetylglucosamine-6-P, that regulate the transcription of genes through the action of the N-terminal DNA-binding domain pfam00392 (Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043). This domain is found in Swiss:P45427 and Swiss:P31460 that are regulators of sugar biosynthesis operons. It is also in the known structure of FadR where it binds to acyl-coA, the domain is alpha helical. This family has been named as FCD for (FadR C-terminal Domain).


Pssm-ID: 429623 [Multi-domain]  Cd Length: 121  Bit Score: 84.73  E-value: 4.97e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489954096   89 VRQAIECAVVRRAASLINDNQCYLLEQNLHQQRIAIDRKQLNDFFQLDDEFHQKLAQIAECQLAWDTVENIKATIDRVRY 168
Cdd:pfam07729   5 LRAALEPLAARLAAERATDEDLAELEALLEALEAAADAGDLEAFAEADREFHLALAEAAGNPVLARMLESLWDRLRRLRR 84

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 489954096  169 MSLDHVSPPEMLLRQHHDIFSALEKRDVEAVDKAMT 204
Cdd:pfam07729  85 LLLSSPGRLRASLEEHRAILDAIRARDPEAARAAMR 120
FCD smart00895
This entry represents the C-terminal ligand binding domain of many members of the GntR family; ...
 89-209 5.63e-19

This entry represents the C-terminal ligand binding domain of many members of the GntR family; This domain probably binds to a range of effector molecules that regulate the transcription of genes through the action of the N-terminal DNA-binding domain. This domain is found in and that are regulators of sugar biosynthesis operons. Many bacterial transcription regulation proteins bind DNA through a helix-turn-helix (HTH) motif, which can be classified into subfamilies on the basis of sequence similarities. The HTH GntR family has many members distributed among diverse bacterial groups that regulate various biological processes. It was named GntR after the Bacillus subtilis repressor of the gluconate operon. In general, these proteins contain a DNA-binding HTH domain at the N terminus, and an effector binding or oligomerisation domain at the C terminus. The winged-helix DNA-binding domain is well conserved in structure for the whole of the GntR family, and is similar in structure to other transcriptional regulator families. The C-terminal effector-binding and oligomerisation domains are more variable and are consequently used to define the subfamilies. Based on the sequence and structure of the C-terminal domains, the GtnR family can be divided into four major groups, as represented by FadR, HutC, MocR and YtrA, as well as some minor groups such as those represented by AraR and PlmA.


Pssm-ID: 214892 [Multi-domain]  Cd Length: 123  Bit Score: 79.33  E-value: 5.63e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489954096    89 VRQAIECAVVRRAASLINDNQCYLLEQNLHQQRIAIDRK-QLNDFFQLDDEFHQKLAQIAECQLAWDTVENIKATIDRVR 167
Cdd:smart00895   5 VRRALEPLAARLAAERATDEDLAALEALLDAMEAAAAAGdDLEEFAELDREFHRALAEAAGNPVLLELLESLRARLRRLR 84

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|..
gi 489954096   168 YMSLDHvspPEMLLRQHHDIFSALEKRDVEAVDKAMTLHLQE 209
Cdd:smart00895  85 RLSLEA---ARRALDEHRAILDAIRARDAEAARAAMREHLEA 123
PRK03837 PRK03837
transcriptional regulator NanR; Provisional
 21-212 2.22e-18

transcriptional regulator NanR; Provisional


Pssm-ID: 235166 [Multi-domain]  Cd Length: 241  Bit Score: 80.84  E-value: 2.22e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489954096  21 LRRDIVRCLIPPGTPL-SEKEVSVRFDVSRQPVREAFIKLAENGLIQI---------RPQRGSYVN------KISLSQVR 84
Cdd:PRK03837  22 LEQMIRSGEFGPGDQLpSERELMAFFGVGRPAVREALQALKRKGLVQIshgerarvsRPSADTIIGqlsgmaKDFLSQSP 101

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489954096  85 NGCF----VRQAIECAVVRRAASLINDNQCYLLEQNLHQQRIAIDRKQLndFFQLDDEFHQKLAQIA---------ECQL 151
Cdd:PRK03837 102 DGLAhlkqARLFFESSLARYAAEHATDEQIALLRKALERNSQSLGDNAA--FIRSDMEFHRVIAEIPgnpifmaihEALL 179

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 489954096 152 AWdtveNIKATIDRVRYMSLDHVSppemlLRQHHDIFSALEKRDVEAVDKAMTLHLQEISE 212
Cdd:PRK03837 180 DW----LIEARPEVVILHGHENVT-----LQEHIAIVDAIRAHDPDEADRALQSHLNRVSA 231
WHTH_GntR cd07377
Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional ...
 15-76 2.22e-15

Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; This CD represents the winged HTH DNA-binding domain of the GntR (named after the gluconate operon repressor in Bacillus subtilis) family of bacterial transcriptional regulators and their putative homologs found in eukaryota and archaea. The GntR family has over 6000 members distributed among almost all bacterial species, which is comprised of FadR, HutC, MocR, YtrA, AraR, PlmA, and other subfamilies for the regulation of the most varied biological process. The monomeric proteins of the GntR family are characterized by two function domains: a small highly conserved winged helix-turn-helix prokaryotic DNA binding domain in the N-terminus, and a very diverse regulatory ligand-binding domain in the C-terminus for effector-binding/oligomerization, which provides the basis for the subfamily classifications. Binding of the effector to GntR-like transcriptional regulators is presumed to result in a conformational change that regulates the DNA-binding affinity of the repressor. The GntR-like proteins bind as dimers, where each monomer recognizes a half-site of 2-fold symmetric DNA sequences.


Pssm-ID: 153418 [Multi-domain]  Cd Length: 66  Bit Score: 68.24  E-value: 2.22e-15
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 489954096  15 QQIYRILRRDIVRCLIPPGTPL-SEKEVSVRFDVSRQPVREAFIKLAENGLIQIRPQRGSYVN 76
Cdd:cd07377    4 EQIADQLREAILSGELKPGDRLpSERELAEELGVSRTTVREALRELEAEGLVERRPGRGTFVA 66
 
Name Accession Description Interval E-value
GntR COG1802
DNA-binding transcriptional regulator, GntR family [Transcription];
3-223 9.00e-55

DNA-binding transcriptional regulator, GntR family [Transcription];


Pssm-ID: 441407 [Multi-domain]  Cd Length: 222  Bit Score: 174.73  E-value: 9.00e-55
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489954096   3 AESQLNPTQPVNQQIYRILRRDIVRCLIPPGTPLSEKEVSVRFDVSRQPVREAFIKLAENGLIQIRPQRGSYVNKISLSQ 82
Cdd:COG1802    2 TSPSPLRRESLAEQVYEALREAILSGELPPGERLSEAELAERLGVSRTPVREALRRLEAEGLVEIRPNRGARVAPLSPEE 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489954096  83 VRNGCFVRQAIECAVVRRAASLINDNQCYLLEQNLHQQRIAIDRKQLNDFFQLDDEFHQKLAQIAECQLAWDTVENIKAT 162
Cdd:COG1802   82 IRELYEVRAALEGLAARLAAERATPADLARLRALLEELEAAAAAGDVAAYLELDREFHRALVEAAGNPRLAELLRRLRAR 161

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 489954096 163 IDRVRYMSLDHVSPPEMLLRQHHDIFSALEKRDVEAVDKAMTLHLQEISESVQLIRQENRE 223
Cdd:COG1802  162 LRRYRRLSLRSPGRLEESLAEHRAILDALEAGDAEAAAAALRAHLERARERLLEALAAAAA 222
FadR COG2186
DNA-binding transcriptional regulator, FadR family [Transcription];
15-223 3.02e-32

DNA-binding transcriptional regulator, FadR family [Transcription];


Pssm-ID: 441789 [Multi-domain]  Cd Length: 232  Bit Score: 116.96  E-value: 3.02e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489954096  15 QQIYRILRRDIVRCLIPPGTPL-SEKEVSVRFDVSRQPVREAFIKLAENGLIQIRPQRGSYVNKIS----------LSQV 83
Cdd:COG2186   10 EQVAEQLRELILSGELKPGDRLpSERELAEQLGVSRTTVREALRALEALGLVEVRQGGGTFVREPSpwalldplalLLAL 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489954096  84 RNGCF-----VRQAIECAVVRRAASLINDNQCYLLEQNLHQQRIAIDRKQlnDFFQLDDEFHQKLAQIAECQLAWDTVEN 158
Cdd:COG2186   90 DDASLrdlleARLALEPEAARLAAERATDEDLARLEAALAEMEAAADDGE--AFAEADLAFHRAIAEASGNPLLALLLES 167

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 489954096 159 IKATIDRVRYMSLDHVSPPEMLLRQHHDIFSALEKRDVEAVDKAMTLHLQEISESVQLIRQENRE 223
Cdd:COG2186  168 LRELLRRSVRLTLRSPEARERSLAEHRAILDAIRAGDPEAARAAMRAHLEAVRERLREALAERAR 232
FCD pfam07729
FCD domain; This domain is the C-terminal ligand binding domain of many members of the GntR ...
 89-204 4.97e-21

FCD domain; This domain is the C-terminal ligand binding domain of many members of the GntR family. This domain binds to a range of effector molecules, including Lactate, Zn(II), Ni(II), Ca(II), Mg(II), citrate, sugar acids, sialic acid and N-acetylglucosamine-6-P, that regulate the transcription of genes through the action of the N-terminal DNA-binding domain pfam00392 (Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043). This domain is found in Swiss:P45427 and Swiss:P31460 that are regulators of sugar biosynthesis operons. It is also in the known structure of FadR where it binds to acyl-coA, the domain is alpha helical. This family has been named as FCD for (FadR C-terminal Domain).


Pssm-ID: 429623 [Multi-domain]  Cd Length: 121  Bit Score: 84.73  E-value: 4.97e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489954096   89 VRQAIECAVVRRAASLINDNQCYLLEQNLHQQRIAIDRKQLNDFFQLDDEFHQKLAQIAECQLAWDTVENIKATIDRVRY 168
Cdd:pfam07729   5 LRAALEPLAARLAAERATDEDLAELEALLEALEAAADAGDLEAFAEADREFHLALAEAAGNPVLARMLESLWDRLRRLRR 84

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 489954096  169 MSLDHVSPPEMLLRQHHDIFSALEKRDVEAVDKAMT 204
Cdd:pfam07729  85 LLLSSPGRLRASLEEHRAILDAIRARDPEAARAAMR 120
FCD smart00895
This entry represents the C-terminal ligand binding domain of many members of the GntR family; ...
 89-209 5.63e-19

This entry represents the C-terminal ligand binding domain of many members of the GntR family; This domain probably binds to a range of effector molecules that regulate the transcription of genes through the action of the N-terminal DNA-binding domain. This domain is found in and that are regulators of sugar biosynthesis operons. Many bacterial transcription regulation proteins bind DNA through a helix-turn-helix (HTH) motif, which can be classified into subfamilies on the basis of sequence similarities. The HTH GntR family has many members distributed among diverse bacterial groups that regulate various biological processes. It was named GntR after the Bacillus subtilis repressor of the gluconate operon. In general, these proteins contain a DNA-binding HTH domain at the N terminus, and an effector binding or oligomerisation domain at the C terminus. The winged-helix DNA-binding domain is well conserved in structure for the whole of the GntR family, and is similar in structure to other transcriptional regulator families. The C-terminal effector-binding and oligomerisation domains are more variable and are consequently used to define the subfamilies. Based on the sequence and structure of the C-terminal domains, the GtnR family can be divided into four major groups, as represented by FadR, HutC, MocR and YtrA, as well as some minor groups such as those represented by AraR and PlmA.


Pssm-ID: 214892 [Multi-domain]  Cd Length: 123  Bit Score: 79.33  E-value: 5.63e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489954096    89 VRQAIECAVVRRAASLINDNQCYLLEQNLHQQRIAIDRK-QLNDFFQLDDEFHQKLAQIAECQLAWDTVENIKATIDRVR 167
Cdd:smart00895   5 VRRALEPLAARLAAERATDEDLAALEALLDAMEAAAAAGdDLEEFAELDREFHRALAEAAGNPVLLELLESLRARLRRLR 84

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|..
gi 489954096   168 YMSLDHvspPEMLLRQHHDIFSALEKRDVEAVDKAMTLHLQE 209
Cdd:smart00895  85 RLSLEA---ARRALDEHRAILDAIRARDAEAARAAMREHLEA 123
PRK03837 PRK03837
transcriptional regulator NanR; Provisional
 21-212 2.22e-18

transcriptional regulator NanR; Provisional


Pssm-ID: 235166 [Multi-domain]  Cd Length: 241  Bit Score: 80.84  E-value: 2.22e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489954096  21 LRRDIVRCLIPPGTPL-SEKEVSVRFDVSRQPVREAFIKLAENGLIQI---------RPQRGSYVN------KISLSQVR 84
Cdd:PRK03837  22 LEQMIRSGEFGPGDQLpSERELMAFFGVGRPAVREALQALKRKGLVQIshgerarvsRPSADTIIGqlsgmaKDFLSQSP 101

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489954096  85 NGCF----VRQAIECAVVRRAASLINDNQCYLLEQNLHQQRIAIDRKQLndFFQLDDEFHQKLAQIA---------ECQL 151
Cdd:PRK03837 102 DGLAhlkqARLFFESSLARYAAEHATDEQIALLRKALERNSQSLGDNAA--FIRSDMEFHRVIAEIPgnpifmaihEALL 179

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 489954096 152 AWdtveNIKATIDRVRYMSLDHVSppemlLRQHHDIFSALEKRDVEAVDKAMTLHLQEISE 212
Cdd:PRK03837 180 DW----LIEARPEVVILHGHENVT-----LQEHIAIVDAIRAHDPDEADRALQSHLNRVSA 231
HTH_GNTR smart00345
helix_turn_helix gluconate operon transcriptional repressor;
17-75 3.63e-17

helix_turn_helix gluconate operon transcriptional repressor;


Pssm-ID: 197669 [Multi-domain]  Cd Length: 60  Bit Score: 72.61  E-value: 3.63e-17
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 489954096    17 IYRILRRDIVRCLIPPGTPL-SEKEVSVRFDVSRQPVREAFIKLAENGLIQIRPQRGSYV 75
Cdd:smart00345   1 VAERLREDIVSGELRPGDKLpSERELAAQLGVSRTTVREALSRLEAEGLVQRRPGSGTFV 60
WHTH_GntR cd07377
Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional ...
 15-76 2.22e-15

Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; This CD represents the winged HTH DNA-binding domain of the GntR (named after the gluconate operon repressor in Bacillus subtilis) family of bacterial transcriptional regulators and their putative homologs found in eukaryota and archaea. The GntR family has over 6000 members distributed among almost all bacterial species, which is comprised of FadR, HutC, MocR, YtrA, AraR, PlmA, and other subfamilies for the regulation of the most varied biological process. The monomeric proteins of the GntR family are characterized by two function domains: a small highly conserved winged helix-turn-helix prokaryotic DNA binding domain in the N-terminus, and a very diverse regulatory ligand-binding domain in the C-terminus for effector-binding/oligomerization, which provides the basis for the subfamily classifications. Binding of the effector to GntR-like transcriptional regulators is presumed to result in a conformational change that regulates the DNA-binding affinity of the repressor. The GntR-like proteins bind as dimers, where each monomer recognizes a half-site of 2-fold symmetric DNA sequences.


Pssm-ID: 153418 [Multi-domain]  Cd Length: 66  Bit Score: 68.24  E-value: 2.22e-15
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 489954096  15 QQIYRILRRDIVRCLIPPGTPL-SEKEVSVRFDVSRQPVREAFIKLAENGLIQIRPQRGSYVN 76
Cdd:cd07377    4 EQIADQLREAILSGELKPGDRLpSERELAEELGVSRTTVREALRELEAEGLVERRPGRGTFVA 66
GntR pfam00392
Bacterial regulatory proteins, gntR family; This family of regulatory proteins consists of the ...
 15-75 4.75e-15

Bacterial regulatory proteins, gntR family; This family of regulatory proteins consists of the N-terminal HTH region of GntR-like bacterial transcription factors. At the C-terminus there is usually an effector-binding/oligomerization domain. The GntR-like proteins include the following sub-families: MocR, YtrR, FadR, AraR, HutC and PlmA, DevA, DasR. Many of these proteins have been shown experimentally to be autoregulatory, enabling the prediction of operator sites and the discovery of cis/trans relationships. The DasR regulator has been shown to be a global regulator of primary metabolism and development in Streptomyces coelicolor.


Pssm-ID: 306822 [Multi-domain]  Cd Length: 64  Bit Score: 67.25  E-value: 4.75e-15
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 489954096   15 QQIYRILRRDIVRCLIPPGTPL-SEKEVSVRFDVSRQPVREAFIKLAENGLIQIRPQRGSYV 75
Cdd:pfam00392   3 EQVYARLREDILSGRLRPGDKLpSERELAAEFGVSRTTVREALRRLEAEGLVERRQGRGTFV 64
MngR COG2188
DNA-binding transcriptional regulator, GntR family [Transcription];
8-77 1.03e-11

DNA-binding transcriptional regulator, GntR family [Transcription];


Pssm-ID: 441791 [Multi-domain]  Cd Length: 238  Bit Score: 62.19  E-value: 1.03e-11
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 489954096   8 NPTQPVNQQIYRILRRDIVRCLIPPGTPL-SEKEVSVRFDVSRQPVREAFIKLAENGLIQIRPQRGSYVNK 77
Cdd:COG2188    1 SSPVPLYLQIADALRERIESGELPPGDRLpSERELAEEFGVSRMTVRKALDELVEEGLLERRQGRGTFVAE 71
ARO8 COG1167
DNA-binding transcriptional regulator, MocR family, contains an aminotransferase domain ...
 8-76 2.33e-09

DNA-binding transcriptional regulator, MocR family, contains an aminotransferase domain [Transcription, Amino acid transport and metabolism]; DNA-binding transcriptional regulator, MocR family, contains an aminotransferase domain is part of the Pathway/BioSystem: Lysine biosynthesis


Pssm-ID: 440781 [Multi-domain]  Cd Length: 471  Bit Score: 56.38  E-value: 2.33e-09
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489954096   8 NPTQPVNQQIYRILRRDIVRCLIPPGTPL-SEKEVSVRFDVSRQPVREAFIKLAENGLIQIRPQRGSYVN 76
Cdd:COG1167    8 DSSGPLYLQLADALREAILSGRLPPGDRLpSSRELAAQLGVSRSTVVRAYEELEAEGLIESRPGSGTFVA 77
PRK10225 PRK10225
Uxu operon transcriptional regulator;
1-212 1.56e-07

Uxu operon transcriptional regulator;


Pssm-ID: 182318 [Multi-domain]  Cd Length: 257  Bit Score: 50.40  E-value: 1.56e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489954096   1 MAAESQLNPTQPVNQQIyrilRRDIVRCLIPPGTPLS-EKEVSVRFDVSRQPVREAFIKLAENGLIQIRPQRGSYV---- 75
Cdd:PRK10225   2 KSATSAQRPYQEVGAMI----RDLIIKTPYNPGERLPpEREIAEMLDVTRTVVREALIMLEIKGLVEVRRGAGIYVldss 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489954096  76 --NKISLSQVRN----GCF----VRQAIECAVVRRAASLINDNQCYLLEQNLHQQRIAIDRKQLNDFFQLDDEFHQKLAQ 145
Cdd:PRK10225  78 gsHNTDSPDANVcndaGPFellqARQLLESNIAEFAALQATREDIVKMRQALQLEERELASSAPGSSESGDMQFHLAIAE 157

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 489954096 146 IAECQL-------AWDTVENIKATIDRVRYMSlDHVSPPEMLLrQHHDIFSALEKRDVEAVDKAMTLHLQEISE 212
Cdd:PRK10225 158 ATHNSMlvelfrqSWQWRENNPMWIQLHSHLD-DSLYRKEWLG-DHKQILAALIKKDARAAKLAMWQHLENVKQ 229
YhcF COG1725
DNA-binding transcriptional regulator YhcF, GntR family [Transcription];
6-104 3.10e-05

DNA-binding transcriptional regulator YhcF, GntR family [Transcription];


Pssm-ID: 441331 [Multi-domain]  Cd Length: 114  Bit Score: 42.09  E-value: 3.10e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489954096   6 QLNPTQPVNQQIYRILRRDIVRCLIPPGTPL-SEKEVSVRFDVSRQPVREAFIKLAENGLIQIRPQRGSYV---NKISLS 81
Cdd:COG1725    4 DFDSGVPIYEQIADQIKEAIASGELKPGDRLpSVRELAAELGVNPNTVAKAYRELEDEGLIETRRGKGTFVaedARELLE 83

                         90       100
                 ....*....|....*....|...
gi 489954096  82 QVRNGcFVRQAIEcAVVRRAASL 104
Cdd:COG1725   84 ERREE-FLEEALR-ELVAEARRL 104
PRK11534 PRK11534
DNA-binding transcriptional regulator CsiR; Provisional
 9-207 3.42e-05

DNA-binding transcriptional regulator CsiR; Provisional


Pssm-ID: 183181 [Multi-domain]  Cd Length: 224  Bit Score: 43.34  E-value: 3.42e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489954096   9 PTQPVNQQIYRILRRDIVRCLIPPGTPLSEKEVSVRFDVSRQPVREAFIKLAENGLIQIRPQRGSYVNKISLSQVRNGCF 88
Cdd:PRK11534   4 PMQITALDGYRWLKNDIIRGNFQPDEKLRMSLLTSRYALGVGPLREALSQLVAERLVTVVNQKGYRVASMSEQELLDIFD 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489954096  89 VRQAIECAVVRRAASLINDN--QCYLLEQNLHQQRIAID--RKQLNDFFQLDDEFHQKLAQIAECQLAWDTVENIKATID 164
Cdd:PRK11534  84 ARANMEAMLVSLAIARGGDEweADVLAKAHLLSKLEACDasEKMLDEWDLRHQAFHTAIVAGCGSHYLLQMRERLFDLAA 163

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*..
gi 489954096 165 RVRYMSLDH-VSPPEML---LRQHHDIFSALEKRDVEAVDKAMTLHL 207
Cdd:PRK11534 164 RYRFIWLRRtVLSVEMLedkHDQHQTLTAAILARDTARASELMRQHL 210
pdhR PRK09464
pyruvate dehydrogenase complex transcriptional repressor PdhR;
9-77 4.61e-03

pyruvate dehydrogenase complex transcriptional repressor PdhR;


Pssm-ID: 181879 [Multi-domain]  Cd Length: 254  Bit Score: 37.31  E-value: 4.61e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 489954096   9 PTQPVNQQ-----IYRILRRDIVRCLIPPGTPL-SEKEVSVRFDVSRQPVREAFIKLAENGLIQIRPQRGSYVNK 77
Cdd:PRK09464   2 AYSKIRQPklsdvIEQQLEFLILEGTLRPGEKLpPERELAKQFDVSRPSLREAIQRLEAKGLLLRRQGGGTFVQS 76
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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