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Conserved domains on  [gi|489949240|ref|WP_003852547|]
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MULTISPECIES: class I SAM-dependent methyltransferase [Pantoea]

Protein Classification

class I SAM-dependent methyltransferase( domain architecture ID 10549394)

class I SAM-dependent methyltransferase catalyzes the methylation of one or more specific substrates using S-adenosyl-L-methionine (SAM or AdoMet) as the methyl donor; similar to Saccharomyces cerevisiae tRNA (carboxymethyluridine(34)-5-O)-methyltransferase

CATH:  2.20.25.110
EC:  2.1.1.-
Gene Ontology:  GO:0032259|GO:0008757|GO:0008168|GO:1904047
PubMed:  12826405
SCOP:  3000118

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Methyltransf_11 pfam08241
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
 77-125 2.25e-12

Methyltransferase domain; Members of this family are SAM dependent methyltransferases.


:

Pssm-ID: 462406 [Multi-domain]  Cd Length: 94  Bit Score: 61.14  E-value: 2.25e-12
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 489949240   77 VLADPMQLPFESKSVDACLMAHTLAWSQDPHRVLREVDRVLIDDGWMII 125
Cdd:pfam08241  46 VVGDAEDLPFPDNSFDLVLSSEVLHHVEDPERALREIARVLKPGGILII 94
 
Name Accession Description Interval E-value
Methyltransf_11 pfam08241
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
 77-125 2.25e-12

Methyltransferase domain; Members of this family are SAM dependent methyltransferases.


Pssm-ID: 462406 [Multi-domain]  Cd Length: 94  Bit Score: 61.14  E-value: 2.25e-12
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 489949240   77 VLADPMQLPFESKSVDACLMAHTLAWSQDPHRVLREVDRVLIDDGWMII 125
Cdd:pfam08241  46 VVGDAEDLPFPDNSFDLVLSSEVLHHVEDPERALREIARVLKPGGILII 94
UbiE COG2226
Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; ...
 77-140 5.27e-12

Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG is part of the Pathway/BioSystem: Biotin biosynthesis


Pssm-ID: 441828 [Multi-domain]  Cd Length: 143  Bit Score: 61.55  E-value: 5.27e-12
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 489949240  77 VLADPMQLPFESKSVDACLMAHTLAWSQDPHRVLREVDRVLIDDGWMIISGFNPFSLLGVSKMV 140
Cdd:COG2226   74 VVGDAEDLPFPDGSFDLVISSFVLHHLPDPERALAEIARVLKPGGRLVVVDFSPPDLAELEELL 137
PRK08317 PRK08317
hypothetical protein; Provisional
 77-174 4.14e-05

hypothetical protein; Provisional


Pssm-ID: 181382 [Multi-domain]  Cd Length: 241  Bit Score: 43.39  E-value: 4.14e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489949240  77 VLADPMQLPFESKSVDACLMAHTLAWSQDPHRVLREVDRVLIDDGWMIISGFNpFSLLGVSKMVPGLTRK---------- 146
Cdd:PRK08317  74 VRGDADGLPFPDGSFDAVRSDRVLQHLEDPARALAEIARVLRPGGRVVVLDTD-WDTLVWHSGDRALMRKilnfwsdhfa 152

                         90       100
                 ....*....|....*....|....*...
gi 489949240 147 APWSGRMFSqmRLLDWLGLLNYEVVYRT 174
Cdd:PRK08317 153 DPWLGRRLP--GLFREAGLTDIEVEPYT 178
MenG_MenH_UbiE TIGR01934
ubiquinone/menaquinone biosynthesis methyltransferases; This model represents a family of ...
 79-121 1.86e-03

ubiquinone/menaquinone biosynthesis methyltransferases; This model represents a family of methyltransferases involved in the biosynthesis of menaquinone and ubiqinone. Some members such as the UbiE enzyme from E. coli are believed to act in both pathways, while others may act in only the menaquinone pathway. These methyltransferases are members of the UbiE/CoQ family of methyltransferases (pfam01209) which also contains ubiquinone methyltransferases and other methyltransferases. Members of this clade include a wide distribution of bacteria and eukaryotes, but no archaea. An outgroup for this clade is provided by the phosphatidylethanolamine methyltransferase (EC 2.1.1.17) from Rhodobacter sphaeroides. Note that a number of non-orthologous genes which are members of pfam03737 have been erroneously annotated as MenG methyltransferases. [Biosynthesis of cofactors, prosthetic groups, and carriers, Menaquinone and ubiquinone]


Pssm-ID: 273884 [Multi-domain]  Cd Length: 223  Bit Score: 38.40  E-value: 1.86e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 489949240   79 ADPMQLPFESKSVDACLMAHTLAWSQDPHRVLREVDRVLIDDG 121
Cdd:TIGR01934  95 ADAEALPFEDNSFDAVTIAFGLRNVTDIQKALREMYRVLKPGG 137
 
Name Accession Description Interval E-value
Methyltransf_11 pfam08241
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
 77-125 2.25e-12

Methyltransferase domain; Members of this family are SAM dependent methyltransferases.


Pssm-ID: 462406 [Multi-domain]  Cd Length: 94  Bit Score: 61.14  E-value: 2.25e-12
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 489949240   77 VLADPMQLPFESKSVDACLMAHTLAWSQDPHRVLREVDRVLIDDGWMII 125
Cdd:pfam08241  46 VVGDAEDLPFPDNSFDLVLSSEVLHHVEDPERALREIARVLKPGGILII 94
UbiE COG2226
Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; ...
 77-140 5.27e-12

Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG is part of the Pathway/BioSystem: Biotin biosynthesis


Pssm-ID: 441828 [Multi-domain]  Cd Length: 143  Bit Score: 61.55  E-value: 5.27e-12
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 489949240  77 VLADPMQLPFESKSVDACLMAHTLAWSQDPHRVLREVDRVLIDDGWMIISGFNPFSLLGVSKMV 140
Cdd:COG2226   74 VVGDAEDLPFPDGSFDLVISSFVLHHLPDPERALAEIARVLKPGGRLVVVDFSPPDLAELEELL 137
UbiG COG2227
2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and ...
 77-129 7.70e-06

2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and metabolism]; 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase is part of the Pathway/BioSystem: Ubiquinone biosynthesis


Pssm-ID: 441829 [Multi-domain]  Cd Length: 126  Bit Score: 44.24  E-value: 7.70e-06
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|...
gi 489949240  77 VLADPMQLPFESKSVDACLMAHTLAWSQDPHRVLREVDRVLIDDGWMIISGFN 129
Cdd:COG2227   74 VQGDLEDLPLEDGSFDLVICSEVLEHLPDPAALLRELARLLKPGGLLLLSTPN 126
PRK08317 PRK08317
hypothetical protein; Provisional
 77-174 4.14e-05

hypothetical protein; Provisional


Pssm-ID: 181382 [Multi-domain]  Cd Length: 241  Bit Score: 43.39  E-value: 4.14e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489949240  77 VLADPMQLPFESKSVDACLMAHTLAWSQDPHRVLREVDRVLIDDGWMIISGFNpFSLLGVSKMVPGLTRK---------- 146
Cdd:PRK08317  74 VRGDADGLPFPDGSFDAVRSDRVLQHLEDPARALAEIARVLRPGGRVVVLDTD-WDTLVWHSGDRALMRKilnfwsdhfa 152

                         90       100
                 ....*....|....*....|....*...
gi 489949240 147 APWSGRMFSqmRLLDWLGLLNYEVVYRT 174
Cdd:PRK08317 153 DPWLGRRLP--GLFREAGLTDIEVEPYT 178
Methyltransf_25 pfam13649
Methyltransferase domain; This family appears to be a methyltransferase domain.
 77-117 1.41e-04

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 463945 [Multi-domain]  Cd Length: 96  Bit Score: 39.85  E-value: 1.41e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 489949240   77 VLADPMQLPFESKSVDACLMAHTLA--WSQDPHRVLREVDRVL 117
Cdd:pfam13649  50 VQGDAEDLPFPDGSFDLVVSSGVLHhlPDPDLEAALREIARVL 92
COG4627 COG4627
Predicted SAM-depedendent methyltransferase [General function prediction only];
84-126 1.55e-03

Predicted SAM-depedendent methyltransferase [General function prediction only];


Pssm-ID: 443666 [Multi-domain]  Cd Length: 161  Bit Score: 37.92  E-value: 1.55e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*
gi 489949240  84 LPFESKSVDACLMAHTL--AWSQDPHRVLREVDRVLIDDGWMIIS 126
Cdd:COG4627   40 LPFPDNSVDAIYSSHVLehLDYEEAPLALKECYRVLKPGGILRIV 84
MenG_MenH_UbiE TIGR01934
ubiquinone/menaquinone biosynthesis methyltransferases; This model represents a family of ...
 79-121 1.86e-03

ubiquinone/menaquinone biosynthesis methyltransferases; This model represents a family of methyltransferases involved in the biosynthesis of menaquinone and ubiqinone. Some members such as the UbiE enzyme from E. coli are believed to act in both pathways, while others may act in only the menaquinone pathway. These methyltransferases are members of the UbiE/CoQ family of methyltransferases (pfam01209) which also contains ubiquinone methyltransferases and other methyltransferases. Members of this clade include a wide distribution of bacteria and eukaryotes, but no archaea. An outgroup for this clade is provided by the phosphatidylethanolamine methyltransferase (EC 2.1.1.17) from Rhodobacter sphaeroides. Note that a number of non-orthologous genes which are members of pfam03737 have been erroneously annotated as MenG methyltransferases. [Biosynthesis of cofactors, prosthetic groups, and carriers, Menaquinone and ubiquinone]


Pssm-ID: 273884 [Multi-domain]  Cd Length: 223  Bit Score: 38.40  E-value: 1.86e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 489949240   79 ADPMQLPFESKSVDACLMAHTLAWSQDPHRVLREVDRVLIDDG 121
Cdd:TIGR01934  95 ADAEALPFEDNSFDAVTIAFGLRNVTDIQKALREMYRVLKPGG 137
ubiE PRK00216
bifunctional demethylmenaquinone methyltransferase/2-methoxy-6-polyprenyl-1,4-benzoquinol ...
 77-117 5.84e-03

bifunctional demethylmenaquinone methyltransferase/2-methoxy-6-polyprenyl-1,4-benzoquinol methylase UbiE;


Pssm-ID: 234689 [Multi-domain]  Cd Length: 239  Bit Score: 37.05  E-value: 5.84e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|.
gi 489949240  77 VLADPMQLPFESKSVDACLMAHTLAWSQDPHRVLREVDRVL 117
Cdd:PRK00216 108 VQGDAEALPFPDNSFDAVTIAFGLRNVPDIDKALREMYRVL 148
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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