hexulose-6-phosphate isomerase, putative; This family shows similarity by PSI-BLAST to other ...
4-282
0e+00
hexulose-6-phosphate isomerase, putative; This family shows similarity by PSI-BLAST to other isomerases. Putative identification as hexulose-6-phosphate isomerase is reported in Swiss-Prot, attributing a discussion in Genome Sci. Technol. 1:53-75(1996). This family is conserved at better than 40 % identity among the four known examples from three species: Escherichia coli (SgbU and SgaU), Haemophilus influenzae, and Mycoplasma pneumoniae. The rarity of the family, high level of conservation, and proposed catabolic role suggests lateral transfer may be a part of the evolutionary history of this protein. [Energy metabolism, Sugars]
Pssm-ID: 129633 Cd Length: 279 Bit Score: 512.09 E-value: 0e+00
Xylose isomerase-like TIM barrel; This TIM alpha/beta barrel structure is found in xylose ...
25-274
7.02e-56
Xylose isomerase-like TIM barrel; This TIM alpha/beta barrel structure is found in xylose isomerase and in endonuclease IV (EC:3.1.21.2). This domain is also found in the N termini of bacterial myo-inositol catabolism proteins. These are involved in the myo-inositol catabolism pathway, and is required for growth on myo-inositol in Rhizobium leguminosarum bv. viciae.
Pssm-ID: 426164 [Multi-domain] Cd Length: 248 Bit Score: 180.26 E-value: 7.02e-56
AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester ...
8-274
1.35e-48
AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of D-arabino-6-hexulose 3-phosphate to D-fructose 6-phosphate, via cleaving the phosphoesterbond with the sugar.
Pssm-ID: 237986 Cd Length: 279 Bit Score: 162.49 E-value: 1.35e-48
cobamide remodeling phosphodiesterase CbiR; Rare cobamides, analogs of B12 with critical ...
33-255
1.20e-03
cobamide remodeling phosphodiesterase CbiR; Rare cobamides, analogs of B12 with critical differences in the lower ligand, can become available for a salvage-like pathway to B12 biosynthesis through the action of enzymes that cleave the lower ligand. Members of this family are CbiR, a phosphodiesterase, which joins CbiZ, a previously discovered amidohydrolase, in the guild of cobamide remodeling enzymes.
Pssm-ID: 469174 Cd Length: 249 Bit Score: 39.54 E-value: 1.20e-03
hexulose-6-phosphate isomerase, putative; This family shows similarity by PSI-BLAST to other ...
4-282
0e+00
hexulose-6-phosphate isomerase, putative; This family shows similarity by PSI-BLAST to other isomerases. Putative identification as hexulose-6-phosphate isomerase is reported in Swiss-Prot, attributing a discussion in Genome Sci. Technol. 1:53-75(1996). This family is conserved at better than 40 % identity among the four known examples from three species: Escherichia coli (SgbU and SgaU), Haemophilus influenzae, and Mycoplasma pneumoniae. The rarity of the family, high level of conservation, and proposed catabolic role suggests lateral transfer may be a part of the evolutionary history of this protein. [Energy metabolism, Sugars]
Pssm-ID: 129633 Cd Length: 279 Bit Score: 512.09 E-value: 0e+00
Xylose isomerase-like TIM barrel; This TIM alpha/beta barrel structure is found in xylose ...
25-274
7.02e-56
Xylose isomerase-like TIM barrel; This TIM alpha/beta barrel structure is found in xylose isomerase and in endonuclease IV (EC:3.1.21.2). This domain is also found in the N termini of bacterial myo-inositol catabolism proteins. These are involved in the myo-inositol catabolism pathway, and is required for growth on myo-inositol in Rhizobium leguminosarum bv. viciae.
Pssm-ID: 426164 [Multi-domain] Cd Length: 248 Bit Score: 180.26 E-value: 7.02e-56
AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester ...
8-274
1.35e-48
AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of D-arabino-6-hexulose 3-phosphate to D-fructose 6-phosphate, via cleaving the phosphoesterbond with the sugar.
Pssm-ID: 237986 Cd Length: 279 Bit Score: 162.49 E-value: 1.35e-48
cobamide remodeling phosphodiesterase CbiR; Rare cobamides, analogs of B12 with critical ...
33-255
1.20e-03
cobamide remodeling phosphodiesterase CbiR; Rare cobamides, analogs of B12 with critical differences in the lower ligand, can become available for a salvage-like pathway to B12 biosynthesis through the action of enzymes that cleave the lower ligand. Members of this family are CbiR, a phosphodiesterase, which joins CbiZ, a previously discovered amidohydrolase, in the guild of cobamide remodeling enzymes.
Pssm-ID: 469174 Cd Length: 249 Bit Score: 39.54 E-value: 1.20e-03
Database: CDSEARCH/cdd Low complexity filter: no Composition Based Adjustment: yes E-value threshold: 0.01
References:
Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
of the residues that compose this conserved feature have been mapped to the query sequence.
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Functional characterization of the conserved domain architecture found on the query.
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if a domain or superfamily has been annotated with functional sites (conserved features),
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click on the bars or triangles to view your query sequence embedded in a multiple sequence alignment of the proteins used to develop the corresponding domain model.
The table lists conserved domains identified on the query sequence. Click on the plus sign (+) on the left to display full descriptions, alignments, and scores.
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(labeled illustration) Standard Display shows only the best scoring domain model from each source, in each hit category listed below for each region on the query sequence.
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