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Conserved domains on  [gi|489927940|ref|WP_003831271|]
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MULTISPECIES: citrate/succinate antiporter CitT [Citrobacter]

Protein Classification

anion permease( domain architecture ID 10469635)

anion permease translocates charged substrates such as sodium, arsenate, antimonite, sulfate and organic anions across biological membranes; similar to Eschericha coli L-tartrate/succinate antiporter

Gene Ontology:  GO:0022857|GO:0005886
TCDB:  2.A.47

Graphical summary

 Zoom to residue level

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List of domain hits

Name Accession Description Interval E-value
Na_sulph_symp pfam00939
Sodium:sulfate symporter transmembrane region; There are also some members in this family that ...
5-486 0e+00

Sodium:sulfate symporter transmembrane region; There are also some members in this family that do not match the Prosite motif, and belong to the subfamily SODIT1.


:

Pssm-ID: 279307 [Multi-domain]  Cd Length: 472  Bit Score: 548.90  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489927940    5 KDKIWKLLAPLVVMGVMFLIPVPDGMPPQAWHYFAVFVAMIVGMILEPIPATAISFIAVTICVIGSNYLLfdaseladpa 84
Cdd:pfam00939   1 LTLWWKLLALLAVLLIILLLPAPDGLPSKAWHLFAIFIATIVGWILEPLPMAVIALFAISLSAILIGTLL---------- 70
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489927940   85 fkagKQALKWGLAGFSSTTVWLVFGAFIFALGYEVTGLGRRIALFLVKFMGKRTLTLGYAIVIIDILLAPFTPSNTARTG 164
Cdd:pfam00939  71 ----AKALSWALSGFSSTTTWLVFGAFFISAAFEKTGLGRRIALVLVKKMGKRTLGLGYGLVFSDLLLAPATPSNTARAG 146
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489927940  165 GTVFPVIKNLPPLFKSFPNDPSARRIGGYLMWMMVISTSLSSSMFVTGAAPNVLGLEFVNKIAGIQISWLQWFLSFLPVG 244
Cdd:pfam00939 147 GIVFPIIMSLPPAFGSDPEKGSERRIGAYLMWTVYQSTSITSAMFLTAMAPNLLLLGLMNSILGVTITWASWFLAAIPPG 226
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489927940  245 IILLIVAPWLSYVLYKPEVTHSAEVAAWAGDELKGMGKLTRKEITLIGLVLLSLGLWVFGGKL-IDATAVGLLAVSLMLA 323
Cdd:pfam00939 227 VILLLLAPLLLYVLYPPEIKSVPDAKAIAKTELKELGPMTFREKALLGLFVLLLLLWIFGGSLnIDATTVAIIGLALMLL 306
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489927940  324 LHVVPWKDITRYNSAWNTLVNLATLVVMANGLTRSGFIDWFANTMSTHLEGFSPNATVIVLVLVFYFAHYLFASLSAHTA 403
Cdd:pfam00939 307 LRILDWKDIVKNKGAWNTLIWLGGLIMLANGLERSGFIEWLGNTLSTSLSGFSPAMAFIIILSLFYLSHYLFASATAHTA 386
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489927940  404 TMLPVILAVGKGIPGVPMEHLCILLVLSIGIMGCLTPYATGPGVIIYGCGYVKSKDYWRLGAIFGVIYIAMLLLVG---W 480
Cdd:pfam00939 387 AMLPIFAAVAQAIPGAPPLLAALLLGFAISLGGFLTPYGTGPGPIYFGSGYLKVKDWWRIGAILTIIGLLILLLLGnwwW 466

                  ....*.
gi 489927940  481 PILAMW 486
Cdd:pfam00939 467 KPLGSL 472
 
Name Accession Description Interval E-value
Na_sulph_symp pfam00939
Sodium:sulfate symporter transmembrane region; There are also some members in this family that ...
5-486 0e+00

Sodium:sulfate symporter transmembrane region; There are also some members in this family that do not match the Prosite motif, and belong to the subfamily SODIT1.


Pssm-ID: 279307 [Multi-domain]  Cd Length: 472  Bit Score: 548.90  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489927940    5 KDKIWKLLAPLVVMGVMFLIPVPDGMPPQAWHYFAVFVAMIVGMILEPIPATAISFIAVTICVIGSNYLLfdaseladpa 84
Cdd:pfam00939   1 LTLWWKLLALLAVLLIILLLPAPDGLPSKAWHLFAIFIATIVGWILEPLPMAVIALFAISLSAILIGTLL---------- 70
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489927940   85 fkagKQALKWGLAGFSSTTVWLVFGAFIFALGYEVTGLGRRIALFLVKFMGKRTLTLGYAIVIIDILLAPFTPSNTARTG 164
Cdd:pfam00939  71 ----AKALSWALSGFSSTTTWLVFGAFFISAAFEKTGLGRRIALVLVKKMGKRTLGLGYGLVFSDLLLAPATPSNTARAG 146
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489927940  165 GTVFPVIKNLPPLFKSFPNDPSARRIGGYLMWMMVISTSLSSSMFVTGAAPNVLGLEFVNKIAGIQISWLQWFLSFLPVG 244
Cdd:pfam00939 147 GIVFPIIMSLPPAFGSDPEKGSERRIGAYLMWTVYQSTSITSAMFLTAMAPNLLLLGLMNSILGVTITWASWFLAAIPPG 226
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489927940  245 IILLIVAPWLSYVLYKPEVTHSAEVAAWAGDELKGMGKLTRKEITLIGLVLLSLGLWVFGGKL-IDATAVGLLAVSLMLA 323
Cdd:pfam00939 227 VILLLLAPLLLYVLYPPEIKSVPDAKAIAKTELKELGPMTFREKALLGLFVLLLLLWIFGGSLnIDATTVAIIGLALMLL 306
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489927940  324 LHVVPWKDITRYNSAWNTLVNLATLVVMANGLTRSGFIDWFANTMSTHLEGFSPNATVIVLVLVFYFAHYLFASLSAHTA 403
Cdd:pfam00939 307 LRILDWKDIVKNKGAWNTLIWLGGLIMLANGLERSGFIEWLGNTLSTSLSGFSPAMAFIIILSLFYLSHYLFASATAHTA 386
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489927940  404 TMLPVILAVGKGIPGVPMEHLCILLVLSIGIMGCLTPYATGPGVIIYGCGYVKSKDYWRLGAIFGVIYIAMLLLVG---W 480
Cdd:pfam00939 387 AMLPIFAAVAQAIPGAPPLLAALLLGFAISLGGFLTPYGTGPGPIYFGSGYLKVKDWWRIGAILTIIGLLILLLLGnwwW 466

                  ....*.
gi 489927940  481 PILAMW 486
Cdd:pfam00939 467 KPLGSL 472
dass TIGR00785
anion transporter; The Divalent Anion:Na+ Symporter (DASS) Family (TC 2.A.47) Functionally ...
25-479 1.94e-165

anion transporter; The Divalent Anion:Na+ Symporter (DASS) Family (TC 2.A.47) Functionally characterized proteins of the DASS family transport (1) organic di- and tricarboxylates of the Krebs Cycle as well as dicarboxylate amino acid, (2) inorganic sulfate and (3) phosphate. The animal NaDC-1 cotransport 3 Na+ with each dicarboxylate. Protonated tricarboxylates are also cotransported with 3Na+. [Transport and binding proteins, Anions, Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273267 [Multi-domain]  Cd Length: 444  Bit Score: 474.53  E-value: 1.94e-165
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489927940   25 PVPDGMPPQAWHYFAVFVAMIVGMILEPIPATAISFIAVTICVIGSNYLLFDASELAdpafkagkqalkwgLAGFSSTTV 104
Cdd:TIGR00785   1 PVPDGLNSGAWLLLAIFVAAIVGWILEPLPLPVTALLAIPIIAVLLGVLSAFKFKNA--------------LSGFADPTI 66
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489927940  105 WLVFGAFIFALGYEVTGLGRRIALFLVKFMGKRTLTLGYAIVIIDILLAPFTPSNTARTGGTVFPVIKNLPPLFKSFPnD 184
Cdd:TIGR00785  67 WLFFGAFILATALVKTGLGKRIAYKLVGKMGGTTLGLGYFLVFLETLLAPMWPSNTARAGGILLPIIKSLLPLLGSKP-E 145
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489927940  185 PSARRIGGYLMWMMVISTSLSSSMFVTGAAPNVLGLEFVNKIAGIQISWLQWFLSFLPVGIILLIVAPWLSYVLYKPEVT 264
Cdd:TIGR00785 146 KSPRKIGKYLMLGIAYSASIGSSGFLTGSAPNALAAGILSKILGIQISWGDWFLAGLPLGIILLLLVPLLLYVLFPPELK 225
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489927940  265 HSAEVAAWAGDELKGMGKLTRKEITLIGLVLLSLGLWVFGGKL-IDATAVGLLAVSLMLALHVVPWKDITRYNSAWNTLV 343
Cdd:TIGR00785 226 LKDEVDLWAKEELEEMGPMSFREKALLGIFLLALLLWIFGGSLgINASVVALLAVVLMLFLGIVTWKDIQKNKVAWNTLI 305
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489927940  344 NLATLVVMANGLTRSGFIDWFANTMSTHLEGFSPNATVIVLVLVFYFAHYLFASLSAHTATMLPVILAVGKgIPGVPMEH 423
Cdd:TIGR00785 306 LFGGLIGLAGGLKKSGFIKWFSEKLVGILDGLSPTIAVLVLVVLFYIILYFFASNTAHTAALVPIFFSVAS-AQGIPLEL 384
                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 489927940  424 LCILLVLSIGIMGCLTPYATGPGVIIYGCGYVKSKDYWRLGAIFGVIYIAMLLLVG 479
Cdd:TIGR00785 385 LALALALSASLMGFLTPYATPPNAIAYGSGYVKIKDMWRVGAIIGIVGLIVLLLVG 440
CitT COG0471
Di- and tricarboxylate antiporter [Carbohydrate transport and metabolism];
108-485 1.04e-79

Di- and tricarboxylate antiporter [Carbohydrate transport and metabolism];


Pssm-ID: 440239 [Multi-domain]  Cd Length: 369  Bit Score: 252.38  E-value: 1.04e-79
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489927940 108 FGAFIFALGYEVTGLGRRIALFLVKFMGKRTLTLGYAIVIIDILLAPFTpSNTARTGgTVFPVIKNLPPLFKSFPNdpsa 187
Cdd:COG0471    1 LGGFVLAAALEKTGLGRRIALLLLKRFGGSPLRLLLGLMLATALLSAFI-SNTARAA-MMLPIALSIAAALGSEKR---- 74
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489927940 188 RRIGGYLMWMMVISTSLSSSMFVTGAAPNVLGLEFVNKIAGIQISWLQWFLSFLPVGIILLIVAPWLSYVLYKPEVTHSA 267
Cdd:COG0471   75 SKFGSALLLPIAFAASIGGMGTLIGTPPNLIAAGLLEEATGIPISFFEWMLVGLPVALVGLLLLWLVLYRLLPPEIKEVP 154
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489927940 268 EVAAWAGDELKGMGKLTRKEITLIGLVLLSLGLWVFGGKL-IDATAVGLLAVSLMLALHVVPWKDITRyNSAWNTLVNLA 346
Cdd:COG0471  155 GSKEVIREELAELGPLSRREKIALAIFALTVLLWITGSLHgIPIAVVALLGAVLLLLTGVLTWKDAYK-SIPWGVLLLFG 233
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489927940 347 TLVVMANGLTRSGFIDWFANTMSTHLEGFSPNATVIVLVLVFYFaHYLFASLSAHTATMLPVILAVGKGIpGVPMEHLCI 426
Cdd:COG0471  234 GGLALGAALEKTGLAAWLADALLPLLGGLSPLLLLLLLALLTLL-LTEFASNTATAALLLPIAISLAQAL-GVNPLPLAL 311
                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 489927940 427 LLVLSIGiMGCLTPYATGPGVIIYGCGYVKSKDYWRLGAIFGVIYIAMLLLVGWPILAM 485
Cdd:COG0471  312 AVAFAAS-CAFLLPVGTPPNAIVYGSGYYKFKDFLKVGLPLNLIGLVVLLLLGPLWWPL 369
ArsB_NhaD_permease cd00625
Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, ...
92-483 1.80e-31

Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a channel-forming subunit of an ATP-driven anion pump.


Pssm-ID: 238344 [Multi-domain]  Cd Length: 396  Bit Score: 125.05  E-value: 1.80e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489927940  92 LKWGLAGFSSTTVWLVFGAFIFALGYEVTGLGRRIALFLVKFMGKRTLTLGYAIVIIDILLAPFtpSNTARTGGTVFPVI 171
Cdd:cd00625   30 PKEALSAIDWETILLLFGMMILSAALEETGLFDRLAAKLARASKGSRRLLLLLMLLTAALSAFF--SNDATAVLLTPIVL 107
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489927940 172 KNLPPLFKSFPNdpsarriggYLMWMMVISTSLSSSMFVTGAAPNVLglefVNKIAGIQISWLQWFLSFLPVGIILLIVA 251
Cdd:cd00625  108 ALLRKLGLSPPV---------PLLLALAFAANIGGAATPIGNPPNLI----IASLSGLGFLDFLAFMAPPALGLLLLLLG 174
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489927940 252 pWLSYVLYKPEVTHSAEVAAWAGDELKGMGKLTRKEITLIGLVLLSLGLWVFGGKLIDATAVGLLAVsLMLALHVVPWKD 331
Cdd:cd00625  175 -LLYLLFRKKLLLPDEDKLTVLAEPLPARPLLKKFLLLALLLLLLFVLLFFFLIPLGLIALLGALLL-LLLLVRGLDPEE 252
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489927940 332 ITRyNSAWNTLVNLATLVVMANGLTRSGFIDWFANTMSTHLEGFSPNATVIVLVLVFYFAhyLFASLSAHTATMLPVILA 411
Cdd:cd00625  253 VLK-SVDWGTLLFFAGLFVLVGALESTGLLEWLAELLVALVGLPPLAALLLIGLLSALLS--NFISNVPTVALLLPIAAS 329
                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 489927940 412 VGkgipgvPMEHLCILLVLSIGIMGCLTPYATGPGVIIYGCGYVKSKDY-WRLGAIFGVIYIAMLLLVGWPIL 483
Cdd:cd00625  330 LA------PPEPAWLALALGSTLGGNLTLIGSLANLIPLGAAENAGVGIsFGEFLKVGLPLTLLSLVVSLLYL 396
 
Name Accession Description Interval E-value
Na_sulph_symp pfam00939
Sodium:sulfate symporter transmembrane region; There are also some members in this family that ...
5-486 0e+00

Sodium:sulfate symporter transmembrane region; There are also some members in this family that do not match the Prosite motif, and belong to the subfamily SODIT1.


Pssm-ID: 279307 [Multi-domain]  Cd Length: 472  Bit Score: 548.90  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489927940    5 KDKIWKLLAPLVVMGVMFLIPVPDGMPPQAWHYFAVFVAMIVGMILEPIPATAISFIAVTICVIGSNYLLfdaseladpa 84
Cdd:pfam00939   1 LTLWWKLLALLAVLLIILLLPAPDGLPSKAWHLFAIFIATIVGWILEPLPMAVIALFAISLSAILIGTLL---------- 70
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489927940   85 fkagKQALKWGLAGFSSTTVWLVFGAFIFALGYEVTGLGRRIALFLVKFMGKRTLTLGYAIVIIDILLAPFTPSNTARTG 164
Cdd:pfam00939  71 ----AKALSWALSGFSSTTTWLVFGAFFISAAFEKTGLGRRIALVLVKKMGKRTLGLGYGLVFSDLLLAPATPSNTARAG 146
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489927940  165 GTVFPVIKNLPPLFKSFPNDPSARRIGGYLMWMMVISTSLSSSMFVTGAAPNVLGLEFVNKIAGIQISWLQWFLSFLPVG 244
Cdd:pfam00939 147 GIVFPIIMSLPPAFGSDPEKGSERRIGAYLMWTVYQSTSITSAMFLTAMAPNLLLLGLMNSILGVTITWASWFLAAIPPG 226
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489927940  245 IILLIVAPWLSYVLYKPEVTHSAEVAAWAGDELKGMGKLTRKEITLIGLVLLSLGLWVFGGKL-IDATAVGLLAVSLMLA 323
Cdd:pfam00939 227 VILLLLAPLLLYVLYPPEIKSVPDAKAIAKTELKELGPMTFREKALLGLFVLLLLLWIFGGSLnIDATTVAIIGLALMLL 306
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489927940  324 LHVVPWKDITRYNSAWNTLVNLATLVVMANGLTRSGFIDWFANTMSTHLEGFSPNATVIVLVLVFYFAHYLFASLSAHTA 403
Cdd:pfam00939 307 LRILDWKDIVKNKGAWNTLIWLGGLIMLANGLERSGFIEWLGNTLSTSLSGFSPAMAFIIILSLFYLSHYLFASATAHTA 386
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489927940  404 TMLPVILAVGKGIPGVPMEHLCILLVLSIGIMGCLTPYATGPGVIIYGCGYVKSKDYWRLGAIFGVIYIAMLLLVG---W 480
Cdd:pfam00939 387 AMLPIFAAVAQAIPGAPPLLAALLLGFAISLGGFLTPYGTGPGPIYFGSGYLKVKDWWRIGAILTIIGLLILLLLGnwwW 466

                  ....*.
gi 489927940  481 PILAMW 486
Cdd:pfam00939 467 KPLGSL 472
dass TIGR00785
anion transporter; The Divalent Anion:Na+ Symporter (DASS) Family (TC 2.A.47) Functionally ...
25-479 1.94e-165

anion transporter; The Divalent Anion:Na+ Symporter (DASS) Family (TC 2.A.47) Functionally characterized proteins of the DASS family transport (1) organic di- and tricarboxylates of the Krebs Cycle as well as dicarboxylate amino acid, (2) inorganic sulfate and (3) phosphate. The animal NaDC-1 cotransport 3 Na+ with each dicarboxylate. Protonated tricarboxylates are also cotransported with 3Na+. [Transport and binding proteins, Anions, Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273267 [Multi-domain]  Cd Length: 444  Bit Score: 474.53  E-value: 1.94e-165
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489927940   25 PVPDGMPPQAWHYFAVFVAMIVGMILEPIPATAISFIAVTICVIGSNYLLFDASELAdpafkagkqalkwgLAGFSSTTV 104
Cdd:TIGR00785   1 PVPDGLNSGAWLLLAIFVAAIVGWILEPLPLPVTALLAIPIIAVLLGVLSAFKFKNA--------------LSGFADPTI 66
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489927940  105 WLVFGAFIFALGYEVTGLGRRIALFLVKFMGKRTLTLGYAIVIIDILLAPFTPSNTARTGGTVFPVIKNLPPLFKSFPnD 184
Cdd:TIGR00785  67 WLFFGAFILATALVKTGLGKRIAYKLVGKMGGTTLGLGYFLVFLETLLAPMWPSNTARAGGILLPIIKSLLPLLGSKP-E 145
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489927940  185 PSARRIGGYLMWMMVISTSLSSSMFVTGAAPNVLGLEFVNKIAGIQISWLQWFLSFLPVGIILLIVAPWLSYVLYKPEVT 264
Cdd:TIGR00785 146 KSPRKIGKYLMLGIAYSASIGSSGFLTGSAPNALAAGILSKILGIQISWGDWFLAGLPLGIILLLLVPLLLYVLFPPELK 225
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489927940  265 HSAEVAAWAGDELKGMGKLTRKEITLIGLVLLSLGLWVFGGKL-IDATAVGLLAVSLMLALHVVPWKDITRYNSAWNTLV 343
Cdd:TIGR00785 226 LKDEVDLWAKEELEEMGPMSFREKALLGIFLLALLLWIFGGSLgINASVVALLAVVLMLFLGIVTWKDIQKNKVAWNTLI 305
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489927940  344 NLATLVVMANGLTRSGFIDWFANTMSTHLEGFSPNATVIVLVLVFYFAHYLFASLSAHTATMLPVILAVGKgIPGVPMEH 423
Cdd:TIGR00785 306 LFGGLIGLAGGLKKSGFIKWFSEKLVGILDGLSPTIAVLVLVVLFYIILYFFASNTAHTAALVPIFFSVAS-AQGIPLEL 384
                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 489927940  424 LCILLVLSIGIMGCLTPYATGPGVIIYGCGYVKSKDYWRLGAIFGVIYIAMLLLVG 479
Cdd:TIGR00785 385 LALALALSASLMGFLTPYATPPNAIAYGSGYVKIKDMWRVGAIIGIVGLIVLLLVG 440
CitT COG0471
Di- and tricarboxylate antiporter [Carbohydrate transport and metabolism];
108-485 1.04e-79

Di- and tricarboxylate antiporter [Carbohydrate transport and metabolism];


Pssm-ID: 440239 [Multi-domain]  Cd Length: 369  Bit Score: 252.38  E-value: 1.04e-79
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489927940 108 FGAFIFALGYEVTGLGRRIALFLVKFMGKRTLTLGYAIVIIDILLAPFTpSNTARTGgTVFPVIKNLPPLFKSFPNdpsa 187
Cdd:COG0471    1 LGGFVLAAALEKTGLGRRIALLLLKRFGGSPLRLLLGLMLATALLSAFI-SNTARAA-MMLPIALSIAAALGSEKR---- 74
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489927940 188 RRIGGYLMWMMVISTSLSSSMFVTGAAPNVLGLEFVNKIAGIQISWLQWFLSFLPVGIILLIVAPWLSYVLYKPEVTHSA 267
Cdd:COG0471   75 SKFGSALLLPIAFAASIGGMGTLIGTPPNLIAAGLLEEATGIPISFFEWMLVGLPVALVGLLLLWLVLYRLLPPEIKEVP 154
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489927940 268 EVAAWAGDELKGMGKLTRKEITLIGLVLLSLGLWVFGGKL-IDATAVGLLAVSLMLALHVVPWKDITRyNSAWNTLVNLA 346
Cdd:COG0471  155 GSKEVIREELAELGPLSRREKIALAIFALTVLLWITGSLHgIPIAVVALLGAVLLLLTGVLTWKDAYK-SIPWGVLLLFG 233
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489927940 347 TLVVMANGLTRSGFIDWFANTMSTHLEGFSPNATVIVLVLVFYFaHYLFASLSAHTATMLPVILAVGKGIpGVPMEHLCI 426
Cdd:COG0471  234 GGLALGAALEKTGLAAWLADALLPLLGGLSPLLLLLLLALLTLL-LTEFASNTATAALLLPIAISLAQAL-GVNPLPLAL 311
                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 489927940 427 LLVLSIGiMGCLTPYATGPGVIIYGCGYVKSKDYWRLGAIFGVIYIAMLLLVGWPILAM 485
Cdd:COG0471  312 AVAFAAS-CAFLLPVGTPPNAIVYGSGYYKFKDFLKVGLPLNLIGLVVLLLLGPLWWPL 369
ArsB_NhaD_permease cd00625
Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, ...
92-483 1.80e-31

Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a channel-forming subunit of an ATP-driven anion pump.


Pssm-ID: 238344 [Multi-domain]  Cd Length: 396  Bit Score: 125.05  E-value: 1.80e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489927940  92 LKWGLAGFSSTTVWLVFGAFIFALGYEVTGLGRRIALFLVKFMGKRTLTLGYAIVIIDILLAPFtpSNTARTGGTVFPVI 171
Cdd:cd00625   30 PKEALSAIDWETILLLFGMMILSAALEETGLFDRLAAKLARASKGSRRLLLLLMLLTAALSAFF--SNDATAVLLTPIVL 107
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489927940 172 KNLPPLFKSFPNdpsarriggYLMWMMVISTSLSSSMFVTGAAPNVLglefVNKIAGIQISWLQWFLSFLPVGIILLIVA 251
Cdd:cd00625  108 ALLRKLGLSPPV---------PLLLALAFAANIGGAATPIGNPPNLI----IASLSGLGFLDFLAFMAPPALGLLLLLLG 174
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489927940 252 pWLSYVLYKPEVTHSAEVAAWAGDELKGMGKLTRKEITLIGLVLLSLGLWVFGGKLIDATAVGLLAVsLMLALHVVPWKD 331
Cdd:cd00625  175 -LLYLLFRKKLLLPDEDKLTVLAEPLPARPLLKKFLLLALLLLLLFVLLFFFLIPLGLIALLGALLL-LLLLVRGLDPEE 252
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489927940 332 ITRyNSAWNTLVNLATLVVMANGLTRSGFIDWFANTMSTHLEGFSPNATVIVLVLVFYFAhyLFASLSAHTATMLPVILA 411
Cdd:cd00625  253 VLK-SVDWGTLLFFAGLFVLVGALESTGLLEWLAELLVALVGLPPLAALLLIGLLSALLS--NFISNVPTVALLLPIAAS 329
                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 489927940 412 VGkgipgvPMEHLCILLVLSIGIMGCLTPYATGPGVIIYGCGYVKSKDY-WRLGAIFGVIYIAMLLLVGWPIL 483
Cdd:cd00625  330 LA------PPEPAWLALALGSTLGGNLTLIGSLANLIPLGAAENAGVGIsFGEFLKVGLPLTLLSLVVSLLYL 396
SLC13_permease cd01115
Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been ...
38-479 9.55e-17

Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is related to renal and intestinal Na+/sulfate cotransporters and a few putative bacterial permeases. The SLC13-type proteins belong to the ArsB/NhaD superfamily of permeases that translocate sodium and various anions across biological membranes in all three kingdoms of life. A typical ArsB/NhaD permease is composed of 8-13 transmembrane helices.


Pssm-ID: 238535 [Multi-domain]  Cd Length: 382  Bit Score: 81.86  E-value: 9.55e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489927940  38 FAVFVAMIVGMILEPIPATAISFIAVTICVIGSnylLFDASELadpafkagkqalkwgLAGFSSTTVWLVFGAFIFALGY 117
Cdd:cd01115    1 LAILVFAAVLFVTEALPLDVTALLVPVLLVLLG---VVPPKEA---------------FSGFSDPAVILFLAGFILGAAL 62
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489927940 118 EVTGLGRRIALFLVKFMGKRTLTLGYAIVIIDILLAPFTpSNTArTGGTVFPVIKnlpPLFKSFPNDPSArriggyLMWM 197
Cdd:cd01115   63 TRTGLAKRIATKLLKRAGKGERRLLLLLMLVTAFLSAFM-SNTA-TVAIMLPVAL---GLAAKLDISPSR------LLMP 131
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489927940 198 MVISTSLSSSMFVTGAAPNVLGLEFVNKIAGiqisWLQWFLSFLPVGIILLIVApWLSYVLYKPEVTHSaevaawagdel 277
Cdd:cd01115  132 LAFAASIGGMLTLIGTPPNLVASGYLESLGG----QGFSFFEFTPIGLPLLIIG-LLYLWFIFRLAVLI----------- 195
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489927940 278 kgmgkltrkeITLIGLVLLSLGLWVFGgklidATAVGLLAVSLMLALHVVPWKDItrYNS-AWNTLVNLATLVVMANGLT 356
Cdd:cd01115  196 ----------ITIVLLAALAAITGLLP-----VSVAIAIGAIVLVFGGVLLTKED--YKSiDWGIIFLFAGGIPLGKALE 258
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489927940 357 RSGFIDWFANTMSTHLEGFSPnatvIVLVLVFYFAHYLFASLSAHTAT---MLPVILAVGKGIPGVPmehlcILLVLSIG 433
Cdd:cd01115  259 SSGAAALIAEALISLLGGLPP----FAILLLLCLLTLVLTNFISNTATavlLAPIALSIALSLGLPP-----EALLLAVA 329
                        410       420       430       440
                 ....*....|....*....|....*....|....*....|....*....
gi 489927940 434 I---MGCLTPYATGPGVIIYGCGYVKSKDYWRLGAIFGVIYIAMLLLVG 479
Cdd:cd01115  330 IgasCAFMLPVGTPPNAIVLGPGGYKFSDFAKVGLPLSILSLVVSVTMI 378
CitMHS pfam03600
Citrate transporter;
92-433 6.20e-10

Citrate transporter;


Pssm-ID: 460985 [Multi-domain]  Cd Length: 342  Bit Score: 60.79  E-value: 6.20e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489927940   92 LKWGLAGFSSTTVWLVFGAFIFALGYEVTGLGRRIALFLVKFMGKRTLTLGYAIVIIDILLAPFtPSNTArTGGTVFPVI 171
Cdd:pfam03600  30 PEEALSGIDSPTILLLLGMMIIGAILERTGLFDRLALKLLRLAGGKPRRLLVALMLATALLSAF-LSNDG-TVLIMIPIV 107
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489927940  172 KnlpPLFKSFPNDPSArriggyLMWMMVISTSLSSSMFVTGAAPNVLgLEFVNKIAGIQISwlqwFLSFLPVGIILLIVA 251
Cdd:pfam03600 108 L---ALARRLGLPPSP------LLIALAFAANIGGTATPIGDPPNII-IASALGLSFGDFG----FFMFPPVGVALLLVG 173
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489927940  252 PWLSYVLYKPEVTHSAEVAAwagdELKGMGKLTRKEITLIGLVLLSLGLWVFGgkLIDATAVGLLAVSLMLALHVVPWKD 331
Cdd:pfam03600 174 LLPLLLIFRKLLPVRKEEEA----ELEELRKRAIKDKLLLAISALVLALVILG--FLLLSVLALAGALLLLLTGVLDPEE 247
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489927940  332 ITRYNSaWNTLVNLATLVVMANGLTRSGFIDWFANTMsthlEGFSPNATVIVLVLVFYFAHYLFASLSAHTATMLPVILA 411
Cdd:pfam03600 248 ALKAVD-WSTLLFFAGLFILVGALEKTGLADALADAL----GGLSGLLVALALILWLSALLSAFISNVPTAALMAPIIVG 322
                         330       340
                  ....*....|....*....|..
gi 489927940  412 VGKGIPGVPMEHLciLLVLSIG 433
Cdd:pfam03600 323 MAPAAGLGDPDPL--AWALAVG 342
ArsB COG1055
Na+/H+ antiporter NhaD or related arsenite permease [Inorganic ion transport and metabolism];
39-451 2.38e-06

Na+/H+ antiporter NhaD or related arsenite permease [Inorganic ion transport and metabolism];


Pssm-ID: 440675 [Multi-domain]  Cd Length: 415  Bit Score: 49.74  E-value: 2.38e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489927940  39 AVFVAMIVGMILEP--IPATAISFIAVTICVIGSnylLFDASELadpafkagkqalkwgLAGFSSTTVWLVFGAFIFALG 116
Cdd:COG1055    7 AIFVLTYLLIILEPrgLNRAVAALLGAALLLLLG---VVSLEDA---------------LEAIDWNTILFLLGMMIIVAI 68
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489927940 117 YEVTGLGRRIALFLVKFMGKRTLTLGYAIVIIDILLAPFTPSNTARTGGT--VFPVIKNLPplFKSFPndpsarriggYL 194
Cdd:COG1055   69 LDESGFFEWLAIKLARRAKGSPRRLLWLLGLLTALLSAFLDNDTTALLLTpvVLAIARRLG--LNPVP----------FL 136
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489927940 195 MwMMVISTSLSSSMFVTGAAPNVLglefvnkIAGI-QISWLQWFLSFLPVGIILLIVAPWLSYVLYKPEVTHSAEVAAWA 273
Cdd:COG1055  137 I-AIVFAANIGGAATPIGNPTNIM-------IASAgGLSFLDFLANLFPPSLVSLLVTLLVLYLLFRKELPAAPDLEDDP 208
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489927940 274 GDELKGMGKLTrkeITLIGLVLLSLGLWVFGGKLIDATAVGLLAVSLMLALHVVPWKDITRyNSAWNTLVNLATLVVMAN 353
Cdd:COG1055  209 KEAIKDRRLLR---ISLLVLALLLVGFVLHSFLGLPPALIALLGAAVLLLLARVDVREVLK-KVDWSTLLFFIGLFVVVG 284
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489927940 354 GLTRSGFIDWFANTMSTHLEGFSPNATVIVLVLVfyfahylfASLSA------HTATMLPVILAVGKGIPGVPMEHlciL 427
Cdd:COG1055  285 GLENTGLLDLLAELLASLTGGNLLLAALLILWLS--------AILSAvvdnvpLVAALLPLIPDLGATGNPEPLWL---A 353
                        410       420
                 ....*....|....*....|....
gi 489927940 428 LVLSIGIMGCLTPYATGPGVIIYG 451
Cdd:COG1055  354 LALGATLGGNLTPIGSAANVIVLG 377
ArsB COG1055
Na+/H+ antiporter NhaD or related arsenite permease [Inorganic ion transport and metabolism];
287-440 7.28e-04

Na+/H+ antiporter NhaD or related arsenite permease [Inorganic ion transport and metabolism];


Pssm-ID: 440675 [Multi-domain]  Cd Length: 415  Bit Score: 42.04  E-value: 7.28e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489927940 287 EITLIGLVLLSLGLWVFGGKLIDATAVGLLAVSLMLALHVVPWKDITRYnSAWNTLVNLATLVVMANGLTRSGFIDWFAN 366
Cdd:COG1055    2 MILALAIFVLTYLLIILEPRGLNRAVAALLGAALLLLLGVVSLEDALEA-IDWNTILFLLGMMIIVAILDESGFFEWLAI 80
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 489927940 367 TMSThLEGFSPNATVIVLVLVFYFAHYLFASLSAhTATMLPVILAVGK--GIPGVPMehlCILLVLSIGIMGCLTP 440
Cdd:COG1055   81 KLAR-RAKGSPRRLLWLLGLLTALLSAFLDNDTT-ALLLTPVVLAIARrlGLNPVPF---LIAIVFAANIGGAATP 151
CitMHS pfam03600
Citrate transporter;
300-483 4.03e-03

Citrate transporter;


Pssm-ID: 460985 [Multi-domain]  Cd Length: 342  Bit Score: 39.22  E-value: 4.03e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489927940  300 LWVFGGKLIDATAvgLLAVSLMLALHVVPWKDITRYnSAWNTLVNLATLVVMANGLTRSGFIDWFANTMSTHLEGFSPNA 379
Cdd:pfam03600   3 LIITEKLPRDVVA--LLGAVLLVLLGVLTPEEALSG-IDSPTILLLLGMMIIGAILERTGLFDRLALKLLRLAGGKPRRL 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489927940  380 TVIVLVLVFYFAhyLFASLSAHTATMLPVILAVGKgIPGVPMEHLCILLVLSIGIMGCLTPYATGPGVIIYGCGYVKSKD 459
Cdd:pfam03600  80 LVALMLATALLS--AFLSNDGTVLIMIPIVLALAR-RLGLPPSPLLIALAFAANIGGTATPIGDPPNIIIASALGLSFGD 156
                         170       180
                  ....*....|....*....|....*
gi 489927940  460 Y-WRLGAIFGVIYIAMLLLVGWPIL 483
Cdd:pfam03600 157 FgFFMFPPVGVALLLVGLLPLLLIF 181
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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