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Conserved domains on  [gi|489915579|ref|WP_003818979|]
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cation transporting ATPase C-terminal domain-containing protein [Bifidobacterium bifidum]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MgtA super family cl43151
Magnesium-transporting ATPase (P-type) [Inorganic ion transport and metabolism];
8-80 9.42e-17

Magnesium-transporting ATPase (P-type) [Inorganic ion transport and metabolism];


The actual alignment was detected with superfamily member COG0474:

Pssm-ID: 440242 [Multi-domain]  Cd Length: 874  Bit Score: 72.83  E-value: 9.42e-17
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 489915579   8 PRGGSLTVGLFSNRTINIGIVTEIVLLVLITEVPVLQTVFHTAPLGWDDCVYLCCIPFVILGIEELRKLIWRH 80
Cdd:COG0474  799 ERRSFFKSGLFPNRPLLLAVLLSLLLQLLLIYVPPLQALFGTVPLPLSDWLLILGLALLYLLLVELVKLLRRR 871
 
Name Accession Description Interval E-value
MgtA COG0474
Magnesium-transporting ATPase (P-type) [Inorganic ion transport and metabolism];
8-80 9.42e-17

Magnesium-transporting ATPase (P-type) [Inorganic ion transport and metabolism];


Pssm-ID: 440242 [Multi-domain]  Cd Length: 874  Bit Score: 72.83  E-value: 9.42e-17
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 489915579   8 PRGGSLTVGLFSNRTINIGIVTEIVLLVLITEVPVLQTVFHTAPLGWDDCVYLCCIPFVILGIEELRKLIWRH 80
Cdd:COG0474  799 ERRSFFKSGLFPNRPLLLAVLLSLLLQLLLIYVPPLQALFGTVPLPLSDWLLILGLALLYLLLVELVKLLRRR 871
Cation_ATPase_C pfam00689
Cation transporting ATPase, C-terminus; Members of this families are involved in Na+/K+, H+/K+, ...
 13-77 2.93e-13

Cation transporting ATPase, C-terminus; Members of this families are involved in Na+/K+, H+/K+, Ca++ and Mg++ transport. This family represents 5 transmembrane helices.


Pssm-ID: 376368 [Multi-domain]  Cd Length: 175  Bit Score: 61.10  E-value: 2.93e-13
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 489915579   13 LTVGLFSNRTINIGIVTEIVLLVLITEVPVLQTVFHTAPLGWDDCVYLCCIPFVILGIEELRKLI 77
Cdd:pfam00689 111 FKIGLFSNKLLLLAILLSLLLQLLIIYVPPLQAVFGTTPLSLEQWLIVLLLALVVLLVVELRKLL 175
P-type_ATPase_cation cd02080
P-type cation-transporting ATPase similar to Exiguobacterium aurantiacum Mna, an Na(+)-ATPase, ...
 12-75 4.04e-09

P-type cation-transporting ATPase similar to Exiguobacterium aurantiacum Mna, an Na(+)-ATPase, and Synechocystis sp. PCC 6803 PMA1, a putative Ca(2+)-ATPase; This subfamily includes the P-type Na(+)-ATPase of an alkaliphilic bacterium Exiguobacterium aurantiacum Mna and cyanobacterium Synechocystis sp. PCC 6803 PMA1, a cation-transporting ATPase which may translocate calcium. The P-type ATPases, are a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319775 [Multi-domain]  Cd Length: 819  Bit Score: 51.49  E-value: 4.04e-09
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 489915579  12 SLTVGLFSNRTINIGIVTEIVLLVLITEVPVLQTVFHTAPLGWDDCVYLCCIPFVILGIEELRK 75
Cdd:cd02080  756 ILKLGVFSNKILFLGIGALILLQLAFTYLPFMNSLFGTAPIDLVDWAIILLVGIVVFIVVELEK 819
 
Name Accession Description Interval E-value
MgtA COG0474
Magnesium-transporting ATPase (P-type) [Inorganic ion transport and metabolism];
8-80 9.42e-17

Magnesium-transporting ATPase (P-type) [Inorganic ion transport and metabolism];


Pssm-ID: 440242 [Multi-domain]  Cd Length: 874  Bit Score: 72.83  E-value: 9.42e-17
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 489915579   8 PRGGSLTVGLFSNRTINIGIVTEIVLLVLITEVPVLQTVFHTAPLGWDDCVYLCCIPFVILGIEELRKLIWRH 80
Cdd:COG0474  799 ERRSFFKSGLFPNRPLLLAVLLSLLLQLLLIYVPPLQALFGTVPLPLSDWLLILGLALLYLLLVELVKLLRRR 871
Cation_ATPase_C pfam00689
Cation transporting ATPase, C-terminus; Members of this families are involved in Na+/K+, H+/K+, ...
 13-77 2.93e-13

Cation transporting ATPase, C-terminus; Members of this families are involved in Na+/K+, H+/K+, Ca++ and Mg++ transport. This family represents 5 transmembrane helices.


Pssm-ID: 376368 [Multi-domain]  Cd Length: 175  Bit Score: 61.10  E-value: 2.93e-13
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 489915579   13 LTVGLFSNRTINIGIVTEIVLLVLITEVPVLQTVFHTAPLGWDDCVYLCCIPFVILGIEELRKLI 77
Cdd:pfam00689 111 FKIGLFSNKLLLLAILLSLLLQLLIIYVPPLQAVFGTTPLSLEQWLIVLLLALVVLLVVELRKLL 175
P-type_ATPase_cation cd02080
P-type cation-transporting ATPase similar to Exiguobacterium aurantiacum Mna, an Na(+)-ATPase, ...
 12-75 4.04e-09

P-type cation-transporting ATPase similar to Exiguobacterium aurantiacum Mna, an Na(+)-ATPase, and Synechocystis sp. PCC 6803 PMA1, a putative Ca(2+)-ATPase; This subfamily includes the P-type Na(+)-ATPase of an alkaliphilic bacterium Exiguobacterium aurantiacum Mna and cyanobacterium Synechocystis sp. PCC 6803 PMA1, a cation-transporting ATPase which may translocate calcium. The P-type ATPases, are a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319775 [Multi-domain]  Cd Length: 819  Bit Score: 51.49  E-value: 4.04e-09
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 489915579  12 SLTVGLFSNRTINIGIVTEIVLLVLITEVPVLQTVFHTAPLGWDDCVYLCCIPFVILGIEELRK 75
Cdd:cd02080  756 ILKLGVFSNKILFLGIGALILLQLAFTYLPFMNSLFGTAPIDLVDWAIILLVGIVVFIVVELEK 819
P-type_ATPase_SPCA cd02085
golgi-associated secretory pathway Ca(2+) transport ATPases, similar to human ATPase secretory ...
 14-75 2.98e-05

golgi-associated secretory pathway Ca(2+) transport ATPases, similar to human ATPase secretory pathway Ca(2+) transporting 1/hSPCA1 and Saccharomyces cerevisiae Ca(2+)/Mn(2+)-transporting P-type ATPase, Pmr1p; SPCAs are Ca(2+) pumps important for the golgi-associated secretion pathway, in addition some function as Mn(2+) pumps in Mn(2+) detoxification. Saccharomyces cerevisiae Pmr1p is a high affinity Ca(2+)/Mn(2+) ATPase which transports Ca(2+) and Mn(2+) from the cytoplasm into the Golgi. Pmr1p also contributes to Cd(2+) detoxification. This subfamily includes human SPCA1 and SPCA2, encoded by the ATP2C1 and ATP2C2 genes; autosomal dominant Hailey-Hailey disease is caused by mutations in the human ATP2C1 gene. It also includes Strongylocentrotus purpuratus testis secretory pathway calcium transporting ATPase SPCA which plays an important role in fertilization. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319779 [Multi-domain]  Cd Length: 804  Bit Score: 40.46  E-value: 2.98e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 489915579  14 TVGLFSNRTINIGIVTEIVLLVLITEVPVLQTVFHTAPLGWDDCVYLCCIPFVILGIEELRK 75
Cdd:cd02085  743 EIGFFSNRMFLYAVGGSLIGQLLVIYFPPLQRVFQTEALGLLDLLFLLGLTSSVFIVSELRK 804
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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