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Conserved domains on  [gi|489910685|ref|WP_003814098|]
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MULTISPECIES: ferric iron uptake transcriptional regulator [Bordetella]

Protein Classification

transcriptional repressor( domain architecture ID 10478445)

transcriptional repressor such as ferric uptake regulators, iron-dependent, DNA-binding repressors and activators involved in iron metabolism, other metalloregulatory proteins, or the peroxide-responsive repressor PerR

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
FUR pfam01475
Ferric uptake regulator family; This family includes metal ion uptake regulator proteins, that ...
 9-129 3.44e-61

Ferric uptake regulator family; This family includes metal ion uptake regulator proteins, that bind to the operator DNA and controls transcription of metal ion-responsive genes. This family is also known as the FUR family.


:

Pssm-ID: 426280  Cd Length: 121  Bit Score: 183.98  E-value: 3.44e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489910685    9 NMGLKATFPRLKILDIFRKSDLRHLSAEDVYRALIAENVEIGLATVYRVLTQFEQAGILTRSQFDTGKAVFELNDGDHHD 88
Cdd:pfam01475   1 EAGLKLTPQRLKILEVLQKSDKEHLSAEEIYKELREEDPNISLATVYRTLNLLEEAGLVKRLEFDGGESRFELNTGHHHD 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 489910685   89 HLICTNCGTVFEFSDPDIEKRQYKVAKDNGFVLESHAMVLY 129
Cdd:pfam01475  81 HLICEDCGKVIEFKDDEIEKRQEEIAKKHGFKLVSHRLELY 121
 
Name Accession Description Interval E-value
FUR pfam01475
Ferric uptake regulator family; This family includes metal ion uptake regulator proteins, that ...
 9-129 3.44e-61

Ferric uptake regulator family; This family includes metal ion uptake regulator proteins, that bind to the operator DNA and controls transcription of metal ion-responsive genes. This family is also known as the FUR family.


Pssm-ID: 426280  Cd Length: 121  Bit Score: 183.98  E-value: 3.44e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489910685    9 NMGLKATFPRLKILDIFRKSDLRHLSAEDVYRALIAENVEIGLATVYRVLTQFEQAGILTRSQFDTGKAVFELNDGDHHD 88
Cdd:pfam01475   1 EAGLKLTPQRLKILEVLQKSDKEHLSAEEIYKELREEDPNISLATVYRTLNLLEEAGLVKRLEFDGGESRFELNTGHHHD 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 489910685   89 HLICTNCGTVFEFSDPDIEKRQYKVAKDNGFVLESHAMVLY 129
Cdd:pfam01475  81 HLICEDCGKVIEFKDDEIEKRQEEIAKKHGFKLVSHRLELY 121
fur PRK09462
ferric uptake regulator; Provisional
 1-135 1.19e-58

ferric uptake regulator; Provisional


Pssm-ID: 236527  Cd Length: 148  Bit Score: 178.39  E-value: 1.19e-58
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489910685   1 MSDQS-ELKNMGLKATFPRLKILDIFRKSDLRHLSAEDVYRALIAENVEIGLATVYRVLTQFEQAGILTRSQFDTGKAVF 79
Cdd:PRK09462   1 MTDNNtALKKAGLKVTLPRLKILEVLQEPDNHHVSAEDLYKRLIDMGEEIGLATVYRVLNQFDDAGIVTRHNFEGGKSVF 80

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 489910685  80 ELNDGDHHDHLICTNCGTVFEFSDPDIEKRQYKVAKDNGFVLESHAMVLYGIC--GNC 135
Cdd:PRK09462  81 ELTQQHHHDHLICLDCGKVIEFSDDSIEARQREIAAKHGIKLTNHSLYLYGHCaeGDC 138
Fur COG0735
Fe2+ or Zn2+ uptake regulation protein Fur/Zur [Inorganic ion transport and metabolism];
6-137 3.25e-57

Fe2+ or Zn2+ uptake regulation protein Fur/Zur [Inorganic ion transport and metabolism];


Pssm-ID: 440498  Cd Length: 140  Bit Score: 174.37  E-value: 3.25e-57
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489910685   6 ELKNMGLKATFPRLKILDIFRKSDlRHLSAEDVYRALIAENVEIGLATVYRVLTQFEQAGILTRSQFDTGKAVFELNDGD 85
Cdd:COG0735   10 LLREAGLRLTPQRLAILELLLESD-RHLSAEEIYEALRKKGPSISLATVYRTLDLLVEAGLVHRIEFGGGKARYELNEGD 88

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 489910685  86 HHDHLICTNCGTVFEFSDPDIEKRQYKVAKDNGFVLESHAMVLYGICGNCQK 137
Cdd:COG0735   89 HHHHLICTKCGKVIELDDDEIEELLEELAEPHGFEIESHELEIYGLCPDCQK 140
Fur_like cd07153
Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, ...
 17-132 6.10e-48

Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Ferric uptake regulator (Fur) and related metalloregulatory proteins are iron-dependent, DNA-binding repressors and activators mainly involved in iron metabolism. A general model for Fur repression under iron-rich conditions is that activated Fur (a dimer having one Fe2+ coordinated per monomer) binds to specific DNA sequences (Fur boxes) in the promoter region of iron-responsive genes, hindering access of RNA polymerase, and repressing transcription. Positive regulation by Fur can be direct or indirect, as in the Fur repression of an anti-sense regulatory small RNA. Some members sense metal ions other than Fe2+. For example, the zinc uptake regulator (Zur) responds to Zn2+, the manganese uptake regulator (Mur) responds to Mn2+, and the nickel uptake regulator (Nur) responds to Ni2+. Other members sense signals other than metal ions. For example, PerR, a metal-dependent sensor of hydrogen peroxide. PerR regulates DNA-binding activity through metal-based protein oxidation, and co-ordinates Mn2+ or Fe2+ at its regulatory site. Fur family proteins contain an N-terminal winged-helix DNA-binding domain followed by a dimerization domain; this CD spans both those domains.


Pssm-ID: 133478 [Multi-domain]  Cd Length: 116  Bit Score: 150.04  E-value: 6.10e-48
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489910685  17 PRLKILDIFRKSDlRHLSAEDVYRALIAENVEIGLATVYRVLTQFEQAGILTRSQFDTGKAVFELNDGDHHDHLICTNCG 96
Cdd:cd07153    2 QRLAILEVLLESD-GHLTAEEIYERLRKKGPSISLATVYRTLELLEEAGLVREIELGDGKARYELNTDEHHHHLICTKCG 80

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 489910685  97 TVFEFSDPDIEKRQYKVAKDNGFVLESHAMVLYGIC 132
Cdd:cd07153   81 KVIDFEDCPLEELLEELAAKTGFKITSHRLELYGIC 116
 
Name Accession Description Interval E-value
FUR pfam01475
Ferric uptake regulator family; This family includes metal ion uptake regulator proteins, that ...
 9-129 3.44e-61

Ferric uptake regulator family; This family includes metal ion uptake regulator proteins, that bind to the operator DNA and controls transcription of metal ion-responsive genes. This family is also known as the FUR family.


Pssm-ID: 426280  Cd Length: 121  Bit Score: 183.98  E-value: 3.44e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489910685    9 NMGLKATFPRLKILDIFRKSDLRHLSAEDVYRALIAENVEIGLATVYRVLTQFEQAGILTRSQFDTGKAVFELNDGDHHD 88
Cdd:pfam01475   1 EAGLKLTPQRLKILEVLQKSDKEHLSAEEIYKELREEDPNISLATVYRTLNLLEEAGLVKRLEFDGGESRFELNTGHHHD 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 489910685   89 HLICTNCGTVFEFSDPDIEKRQYKVAKDNGFVLESHAMVLY 129
Cdd:pfam01475  81 HLICEDCGKVIEFKDDEIEKRQEEIAKKHGFKLVSHRLELY 121
fur PRK09462
ferric uptake regulator; Provisional
 1-135 1.19e-58

ferric uptake regulator; Provisional


Pssm-ID: 236527  Cd Length: 148  Bit Score: 178.39  E-value: 1.19e-58
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489910685   1 MSDQS-ELKNMGLKATFPRLKILDIFRKSDLRHLSAEDVYRALIAENVEIGLATVYRVLTQFEQAGILTRSQFDTGKAVF 79
Cdd:PRK09462   1 MTDNNtALKKAGLKVTLPRLKILEVLQEPDNHHVSAEDLYKRLIDMGEEIGLATVYRVLNQFDDAGIVTRHNFEGGKSVF 80

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 489910685  80 ELNDGDHHDHLICTNCGTVFEFSDPDIEKRQYKVAKDNGFVLESHAMVLYGIC--GNC 135
Cdd:PRK09462  81 ELTQQHHHDHLICLDCGKVIEFSDDSIEARQREIAAKHGIKLTNHSLYLYGHCaeGDC 138
Fur COG0735
Fe2+ or Zn2+ uptake regulation protein Fur/Zur [Inorganic ion transport and metabolism];
6-137 3.25e-57

Fe2+ or Zn2+ uptake regulation protein Fur/Zur [Inorganic ion transport and metabolism];


Pssm-ID: 440498  Cd Length: 140  Bit Score: 174.37  E-value: 3.25e-57
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489910685   6 ELKNMGLKATFPRLKILDIFRKSDlRHLSAEDVYRALIAENVEIGLATVYRVLTQFEQAGILTRSQFDTGKAVFELNDGD 85
Cdd:COG0735   10 LLREAGLRLTPQRLAILELLLESD-RHLSAEEIYEALRKKGPSISLATVYRTLDLLVEAGLVHRIEFGGGKARYELNEGD 88

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 489910685  86 HHDHLICTNCGTVFEFSDPDIEKRQYKVAKDNGFVLESHAMVLYGICGNCQK 137
Cdd:COG0735   89 HHHHLICTKCGKVIELDDDEIEELLEELAEPHGFEIESHELEIYGLCPDCQK 140
Fur_like cd07153
Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, ...
 17-132 6.10e-48

Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Ferric uptake regulator (Fur) and related metalloregulatory proteins are iron-dependent, DNA-binding repressors and activators mainly involved in iron metabolism. A general model for Fur repression under iron-rich conditions is that activated Fur (a dimer having one Fe2+ coordinated per monomer) binds to specific DNA sequences (Fur boxes) in the promoter region of iron-responsive genes, hindering access of RNA polymerase, and repressing transcription. Positive regulation by Fur can be direct or indirect, as in the Fur repression of an anti-sense regulatory small RNA. Some members sense metal ions other than Fe2+. For example, the zinc uptake regulator (Zur) responds to Zn2+, the manganese uptake regulator (Mur) responds to Mn2+, and the nickel uptake regulator (Nur) responds to Ni2+. Other members sense signals other than metal ions. For example, PerR, a metal-dependent sensor of hydrogen peroxide. PerR regulates DNA-binding activity through metal-based protein oxidation, and co-ordinates Mn2+ or Fe2+ at its regulatory site. Fur family proteins contain an N-terminal winged-helix DNA-binding domain followed by a dimerization domain; this CD spans both those domains.


Pssm-ID: 133478 [Multi-domain]  Cd Length: 116  Bit Score: 150.04  E-value: 6.10e-48
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489910685  17 PRLKILDIFRKSDlRHLSAEDVYRALIAENVEIGLATVYRVLTQFEQAGILTRSQFDTGKAVFELNDGDHHDHLICTNCG 96
Cdd:cd07153    2 QRLAILEVLLESD-GHLTAEEIYERLRKKGPSISLATVYRTLELLEEAGLVREIELGDGKARYELNTDEHHHHLICTKCG 80

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 489910685  97 TVFEFSDPDIEKRQYKVAKDNGFVLESHAMVLYGIC 132
Cdd:cd07153   81 KVIDFEDCPLEELLEELAAKTGFKITSHRLELYGIC 116
HTH_ARSR cd00090
Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric ...
 18-91 2.76e-04

Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.


Pssm-ID: 238042 [Multi-domain]  Cd Length: 78  Bit Score: 37.28  E-value: 2.76e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 489910685  18 RLKILDIFRKSDLrhlSAEDvyralIAENVEIGLATVYRVLTQFEQAGILTRSQfDTGKAVFELNDGDHHDHLI 91
Cdd:cd00090    9 RLRILRLLLEGPL---TVSE-----LAERLGLSQSTVSRHLKKLEEAGLVESRR-EGRRVYYSLTDAERLLALL 73
PRK09834 PRK09834
DNA-binding transcriptional regulator;
30-93 3.77e-04

DNA-binding transcriptional regulator;


Pssm-ID: 182100 [Multi-domain]  Cd Length: 263  Bit Score: 38.82  E-value: 3.77e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489910685  30 LRHLSAEDVYR--ALIAENVEIGLATVYRVLTQFEQAGILTRSQFDTG----KAVFELNDGDHHDHLICT 93
Cdd:PRK09834  17 LRALNRLDGGAtvGLLAELTGLHRTTVRRLLETLQEEGYVRRSASDDSfrltLKVRQLSEGFRDEQWISA 86
PRK11639 PRK11639
zinc uptake transcriptional repressor Zur;
85-136 8.12e-04

zinc uptake transcriptional repressor Zur;


Pssm-ID: 183251  Cd Length: 169  Bit Score: 37.43  E-value: 8.12e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 489910685  85 DHHDH----LICTNCGTVFEFSDPDIEKRQYKVAKDNGFVLESHAMVLYGICGNCQ 136
Cdd:PRK11639  92 DQPTHtsamFICDRCGAVKEECAEGVEDIMHTLAAKMGFALRHNVIEAHGLCAACV 147
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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