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Conserved domains on  [gi|489828725|ref|WP_003732482|]
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MULTISPECIES: carboxylesterase [Listeria]

Protein Classification

alpha/beta hydrolase( domain architecture ID 10787854)

alpha/beta hydrolase family protein catalyzes the hydrolysis of substrates with different chemical composition or physicochemical properties using a nucleophile-His-acid catalytic triad

CATH:  3.40.50.1820
EC:  3.-.-.-
Gene Ontology:  GO:0016787
PubMed:  19508187|12369917|37582413

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
YvaK COG1647
Esterase/lipase [Secondary metabolites biosynthesis, transport and catabolism];
1-241 7.07e-77

Esterase/lipase [Secondary metabolites biosynthesis, transport and catabolism];


:

Pssm-ID: 441253 [Multi-domain]  Cd Length: 246  Bit Score: 232.52  E-value: 7.07e-77
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489828725   1 MSADRSFTLKAGNRAVLLLHGFAGTTEDVRELGEILAENGYTVHAPNFRGHGDEPAIFLKTTPEMWYEDAVAGYRQLeKD 80
Cdd:COG1647    3 ILGAEPFFLEGGRKGVLLLHGFTGSPAEMRPLAEALAKAGYTVYAPRLPGHGTSPEDLLKTTWEDWLEDVEEAYEIL-KA 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489828725  81 GYDEIAIVGVAMGGVFALKMAESFS-PKAIVPLCANV---NRKMRYIPIENYLTKQLKKQGIVEQEADQMLKNYLPEIDV 156
Cdd:COG1647   82 GYDKVIVIGLSMGGLLALLLAARYPdVAGLVLLSPALkidDPSAPLLPLLKYLARSLRGIGSDIEDPEVAEYAYDRTPLR 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489828725 157 MTEARATFYKNVARDIEKIHVPTMIGQGCQDEEIDADNANYIFKHIHTNDKQLCFYAGSGHDIVNDCEKDILEEDLIYFL 236
Cdd:COG1647  162 ALAELQRLIREVRRDLPKITAPTLIIQSRKDEVVPPESARYIYERLGSPDKELVWLEDSGHVITLDKDREEVAEEILDFL 241


                 ....*
gi 489828725 237 DDLVW 241
Cdd:COG1647  242 ERLAA 246
 
Name Accession Description Interval E-value
YvaK COG1647
Esterase/lipase [Secondary metabolites biosynthesis, transport and catabolism];
1-241 7.07e-77

Esterase/lipase [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 441253 [Multi-domain]  Cd Length: 246  Bit Score: 232.52  E-value: 7.07e-77
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489828725   1 MSADRSFTLKAGNRAVLLLHGFAGTTEDVRELGEILAENGYTVHAPNFRGHGDEPAIFLKTTPEMWYEDAVAGYRQLeKD 80
Cdd:COG1647    3 ILGAEPFFLEGGRKGVLLLHGFTGSPAEMRPLAEALAKAGYTVYAPRLPGHGTSPEDLLKTTWEDWLEDVEEAYEIL-KA 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489828725  81 GYDEIAIVGVAMGGVFALKMAESFS-PKAIVPLCANV---NRKMRYIPIENYLTKQLKKQGIVEQEADQMLKNYLPEIDV 156
Cdd:COG1647   82 GYDKVIVIGLSMGGLLALLLAARYPdVAGLVLLSPALkidDPSAPLLPLLKYLARSLRGIGSDIEDPEVAEYAYDRTPLR 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489828725 157 MTEARATFYKNVARDIEKIHVPTMIGQGCQDEEIDADNANYIFKHIHTNDKQLCFYAGSGHDIVNDCEKDILEEDLIYFL 236
Cdd:COG1647  162 ALAELQRLIREVRRDLPKITAPTLIIQSRKDEVVPPESARYIYERLGSPDKELVWLEDSGHVITLDKDREEVAEEILDFL 241


                 ....*
gi 489828725 237 DDLVW 241
Cdd:COG1647  242 ERLAA 246
Abhydrolase_1 pfam00561
alpha/beta hydrolase fold; This catalytic domain is found in a very wide range of enzymes.
 15-115 1.29e-12

alpha/beta hydrolase fold; This catalytic domain is found in a very wide range of enzymes.


Pssm-ID: 395444 [Multi-domain]  Cd Length: 245  Bit Score: 65.22  E-value: 1.29e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489828725   15 AVLLLHGFAGTTEDVRELGEILAENGYTVHAPNFRGHGDEPAIflkTTPEMWYEDAVAGY--RQLEKDGYDEIAIVGVAM 92
Cdd:pfam00561   2 PVLLLHGLPGSSDLWRKLAPALARDGFRVIALDLRGFGKSSRP---KAQDDYRTDDLAEDleYILEALGLEKVNLVGHSM 78

                          90       100
                  ....*....|....*....|....*
gi 489828725   93 GGVFALKMAESFSP--KAIVPLCAN 115
Cdd:pfam00561  79 GGLIALAYAAKYPDrvKALVLLGAL 103
hydr2_PEP TIGR03101
exosortase A system-associated hydrolase 2; This group of proteins are members of the alpha ...
 12-134 1.07e-06

exosortase A system-associated hydrolase 2; This group of proteins are members of the alpha/beta hydrolase superfamily. These proteins are generally found in genomes containing the exosortase/PEP-CTERM protein expoert system, specifically the type 1 variant of this system described by the Genome Property GenProp0652. When found in this context they are invariably present in the vicinity of a second, relatively unrelated enzyme (ortholog 1, TIGR03100) of the same superfamily.


Pssm-ID: 274428  Cd Length: 266  Bit Score: 48.27  E-value: 1.07e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489828725   12 GNRAVLLLHGFAGTTEDVRE----LGEILAENGYTVHAPNFRGHGDEPAIFLKTTPEMWYEDAVAGYRQLEKDGYDEIAI 87
Cdd:TIGR03101  24 PRGVVIYLPPFAEEMNKSRRmvalQARAFAAGGFGVLQIDLYGCGDSAGDFAAARWDVWKEDVAAAYRWLIEQGHPPVTL 103

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 489828725   88 VGVAMGGVFALKMAesfspkaiVPLCANVNRKMRYIPIEN---YLTKQLK 134
Cdd:TIGR03101 104 WGLRLGALLALDAA--------NPLAAKCNRLVLWQPVVSgkqQLQQFLR 145
PRK14875 PRK14875
acetoin dehydrogenase E2 subunit dihydrolipoyllysine-residue acetyltransferase; Provisional
 10-103 1.56e-03

acetoin dehydrogenase E2 subunit dihydrolipoyllysine-residue acetyltransferase; Provisional


Pssm-ID: 184875 [Multi-domain]  Cd Length: 371  Bit Score: 39.16  E-value: 1.56e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489828725  10 KAGNRAVLLLHGFAGTTEDVRELGEILAEnGYTVHAPNFRGHGDEPAIFLKTTPEmWYEDAVAGYrqLEKDGYDEIAIVG 89
Cdd:PRK14875 128 EGDGTPVVLIHGFGGDLNNWLFNHAALAA-GRPVIALDLPGHGASSKAVGAGSLD-ELAAAVLAF--LDALGIERAHLVG 203

                         90
                 ....*....|....
gi 489828725  90 VAMGGVFALKMAES 103
Cdd:PRK14875 204 HSMGGAVALRLAAR 217
 
Name Accession Description Interval E-value
YvaK COG1647
Esterase/lipase [Secondary metabolites biosynthesis, transport and catabolism];
1-241 7.07e-77

Esterase/lipase [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 441253 [Multi-domain]  Cd Length: 246  Bit Score: 232.52  E-value: 7.07e-77
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489828725   1 MSADRSFTLKAGNRAVLLLHGFAGTTEDVRELGEILAENGYTVHAPNFRGHGDEPAIFLKTTPEMWYEDAVAGYRQLeKD 80
Cdd:COG1647    3 ILGAEPFFLEGGRKGVLLLHGFTGSPAEMRPLAEALAKAGYTVYAPRLPGHGTSPEDLLKTTWEDWLEDVEEAYEIL-KA 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489828725  81 GYDEIAIVGVAMGGVFALKMAESFS-PKAIVPLCANV---NRKMRYIPIENYLTKQLKKQGIVEQEADQMLKNYLPEIDV 156
Cdd:COG1647   82 GYDKVIVIGLSMGGLLALLLAARYPdVAGLVLLSPALkidDPSAPLLPLLKYLARSLRGIGSDIEDPEVAEYAYDRTPLR 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489828725 157 MTEARATFYKNVARDIEKIHVPTMIGQGCQDEEIDADNANYIFKHIHTNDKQLCFYAGSGHDIVNDCEKDILEEDLIYFL 236
Cdd:COG1647  162 ALAELQRLIREVRRDLPKITAPTLIIQSRKDEVVPPESARYIYERLGSPDKELVWLEDSGHVITLDKDREEVAEEILDFL 241


                 ....*
gi 489828725 237 DDLVW 241
Cdd:COG1647  242 ERLAA 246
PldB COG2267
Lysophospholipase, alpha-beta hydrolase superfamily [Lipid transport and metabolism];
14-238 1.39e-19

Lysophospholipase, alpha-beta hydrolase superfamily [Lipid transport and metabolism];


Pssm-ID: 441868 [Multi-domain]  Cd Length: 221  Bit Score: 83.90  E-value: 1.39e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489828725  14 RAVLLLHGFAGTTEDVRELGEILAENGYTVHAPNFRGHGD-EPAIFLKTTPEMWYEDAVAGYRQLEKDGYDEIAIVGVAM 92
Cdd:COG2267   29 GTVVLVHGLGEHSGRYAELAEALAAAGYAVLAFDLRGHGRsDGPRGHVDSFDDYVDDLRAALDALRARPGLPVVLLGHSM 108

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489828725  93 GGVFALKMAESFSPK--AIVpLCAnvnrkmryiPieNYLTKQLkkqgiveqeadqmlknYLPEIDVMTEARatfyknVAR 170
Cdd:COG2267  109 GGLIALLYAARYPDRvaGLV-LLA---------P--AYRADPL----------------LGPSARWLRALR------LAE 154

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 489828725 171 DIEKIHVPTMIGQGCQDEEIDADNANYIFKHIHTnDKQLCFYAGSGHDIVNDCEKDILEEDLIYFLDD 238
Cdd:COG2267  155 ALARIDVPVLVLHGGADRVVPPEAARRLAARLSP-DVELVLLPGARHELLNEPAREEVLAAILAWLER 221
DAP2 COG1506
Dipeptidyl aminopeptidase/acylaminoacyl peptidase [Amino acid transport and metabolism];
15-237 6.46e-17

Dipeptidyl aminopeptidase/acylaminoacyl peptidase [Amino acid transport and metabolism];


Pssm-ID: 441115 [Multi-domain]  Cd Length: 234  Bit Score: 76.98  E-value: 6.46e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489828725  15 AVLLLHGFAGTTEDV-RELGEILAENGYTVHAPNFRGHGDEPaiflKTTPEMWYEDAVAGYRQLEKDGY---DEIAIVGV 90
Cdd:COG1506   25 VVVYVHGGPGSRDDSfLPLAQALASRGYAVLAPDYRGYGESA----GDWGGDEVDDVLAAIDYLAARPYvdpDRIGIYGH 100

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489828725  91 AMGGVFALKMAeSFSP---KAIVPLCANVNRKMRYIPIENYLTKQLKkqgiVEQEADQMLKNYLPeidvmtearatfykn 167
Cdd:COG1506  101 SYGGYMALLAA-ARHPdrfKAAVALAGVSDLRSYYGTTREYTERLMG----GPWEDPEAYAARSP--------------- 160

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 489828725 168 vARDIEKIHVPTMIGQGCQDEEIDADNANYIFKHIHTN--DKQLCFYAGSGHDIVNDCEKDILEEdLIYFLD 237
Cdd:COG1506  161 -LAYADKLKTPLLLIHGEADDRVPPEQAERLYEALKKAgkPVELLVYPGEGHGFSGAGAPDYLER-ILDFLD 230
MenH COG0596
2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, ...
 14-239 1.09e-14

2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, alpha/beta hydrolase fold [Coenzyme transport and metabolism, General function prediction only]; 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, alpha/beta hydrolase fold is part of the Pathway/BioSystem: Menaquinone biosynthesis


Pssm-ID: 440361 [Multi-domain]  Cd Length: 221  Bit Score: 70.80  E-value: 1.09e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489828725  14 RAVLLLHGFAGTTEDVRELGEILAEnGYTVHAPNFRGHGDEPAIFLKTTPEMWYEDAVAgyrQLEKDGYDEIAIVGVAMG 93
Cdd:COG0596   24 PPVVLLHGLPGSSYEWRPLIPALAA-GYRVIAPDLRGHGRSDKPAGGYTLDDLADDLAA---LLDALGLERVVLVGHSMG 99

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489828725  94 GVFALKMAESFSP--KAIVpLCANVNRKMRyipiENYLTKQLKKQGIVEQeadqmlknylpeidvmteARATFYKNVARD 171
Cdd:COG0596  100 GMVALELAARHPErvAGLV-LVDEVLAALA----EPLRRPGLAPEALAAL------------------LRALARTDLRER 156

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 489828725 172 IEKIHVPTMIGQGCQDEEIDADNANYIFKHIHtnDKQLCFYAGSGHDIVNDcEKDILEEDLIYFLDDL 239
Cdd:COG0596  157 LARITVPTLVIWGEKDPIVPPALARRLAELLP--NAELVVLPGAGHFPPLE-QPEAFAAALRDFLARL 221
FrsA COG1073
Fermentation-respiration switch esterase FrsA, DUF1100 family [Signal transduction mechanisms]; ...
 10-238 1.41e-14

Fermentation-respiration switch esterase FrsA, DUF1100 family [Signal transduction mechanisms];


Pssm-ID: 440691 [Multi-domain]  Cd Length: 253  Bit Score: 70.71  E-value: 1.41e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489828725  10 KAGNRAVLLLHGFAGTTEDVRELGEILAENGYTVHAPNFRGHGD---EPaiflktTPEMWYE--DAVAGYRQL-EKDGYD 83
Cdd:COG1073   34 SKKYPAVVVAHGNGGVKEQRALYAQRLAELGFNVLAFDYRGYGEsegEP------REEGSPErrDARAAVDYLrTLPGVD 107

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489828725  84 E--IAIVGVAMGGVFALKMAESFS-PKAIVPLCANVNRKMryipIENYLTKQLKKQGIveqeadqMLKNYLPEIDVMTEA 160
Cdd:COG1073  108 PerIGLLGISLGGGYALNAAATDPrVKAVILDSPFTSLED----LAAQRAKEARGAYL-------PGVPYLPNVRLASLL 176

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 489828725 161 RATFykNVARDIEKIHVPTMIGQGCQDEEIDADNANYIFKHIhTNDKQLCFYAGSGHDIVNDCEKDILEEDLIYFLDD 238
Cdd:COG1073  177 NDEF--DPLAKIEKISRPLLFIHGEKDEAVPFYMSEDLYEAA-AEPKELLIVPGAGHVDLYDRPEEEYFDKLAEFFKK 251
Abhydrolase_1 pfam00561
alpha/beta hydrolase fold; This catalytic domain is found in a very wide range of enzymes.
 15-115 1.29e-12

alpha/beta hydrolase fold; This catalytic domain is found in a very wide range of enzymes.


Pssm-ID: 395444 [Multi-domain]  Cd Length: 245  Bit Score: 65.22  E-value: 1.29e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489828725   15 AVLLLHGFAGTTEDVRELGEILAENGYTVHAPNFRGHGDEPAIflkTTPEMWYEDAVAGY--RQLEKDGYDEIAIVGVAM 92
Cdd:pfam00561   2 PVLLLHGLPGSSDLWRKLAPALARDGFRVIALDLRGFGKSSRP---KAQDDYRTDDLAEDleYILEALGLEKVNLVGHSM 78

                          90       100
                  ....*....|....*....|....*
gi 489828725   93 GGVFALKMAESFSP--KAIVPLCAN 115
Cdd:pfam00561  79 GGLIALAYAAKYPDrvKALVLLGAL 103
YheT COG0429
Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only];
4-181 2.81e-12

Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only];


Pssm-ID: 440198 [Multi-domain]  Cd Length: 323  Bit Score: 65.16  E-value: 2.81e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489828725   4 DRSFTLKAGNRAVLLLHGFAGTTED--VRELGEILAENGYTVHAPNFRGHGDEPAiflkTTPEMwY-----EDAVAGYRQ 76
Cdd:COG0429   52 DWSDPPAPSKPLVVLLHGLEGSSDShyARGLARALYARGWDVVRLNFRGCGGEPN----LLPRL-YhsgdtEDLVWVLAH 126

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489828725  77 L-EKDGYDEIAIVGVAMGGVFALKMA-----ESFSPKAIVPLCANVN--RKMRYI------PIENYLTKQLKKQ------ 136
Cdd:COG0429  127 LrARYPYAPLYAVGFSLGGNLLLKYLgeqgdDAPPLKAAVAVSPPLDlaASADRLergfnrLYQRYFLRSLKRKlrrkla 206

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 489828725 137 ---GIVEQEADQMLKNyLPEID-VMTeARATFYKNV--------ARD-IEKIHVPTMI 181
Cdd:COG0429  207 lfpGLIDLEALKRIRT-LREFDdAYT-APLHGFKDAedyyqrasALPfLPQIRVPTLI 262
Hydrolase_4 pfam12146
Serine aminopeptidase, S33; This domain is found in bacteria and eukaryotes and is ...
 15-224 1.08e-11

Serine aminopeptidase, S33; This domain is found in bacteria and eukaryotes and is approximately 110 amino acids in length. It is found in association with pfam00561. The majority of the members in this family carry the exopeptidase active-site residues of Ser-122, Asp-239 and His-269 as in UniProtKB:Q7ZWC2.


Pssm-ID: 463473 [Multi-domain]  Cd Length: 238  Bit Score: 62.62  E-value: 1.08e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489828725   15 AVLLLHGFAGTTEDVRELGEILAENGYTVHAPNFRGHGdepaiflKTTPEMWY--------EDAVAGYRQL-EKDGYDEI 85
Cdd:pfam12146   6 VVVLVHGLGEHSGRYAHLADALAAQGFAVYAYDHRGHG-------RSDGKRGHvpsfddyvDDLDTFVDKIrEEHPGLPL 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489828725   86 AIVGVAMGGV----FALKMAESFS------------PKAIVPLCANVNRKMRYIPIENYLTKQLKKQGI------VEQ-E 142
Cdd:pfam12146  79 FLLGHSMGGLiaalYALRYPDKVDglilsapalkikPYLAPPILKLLAKLLGKLFPRLRVPNNLLPDSLsrdpevVAAyA 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489828725  143 ADQMLKNYLPeIDVMTEA-RATfyKNVARDIEKIHVPTMIGQGCQDEEIDADNANYIFKHIHTNDKQLCFYAGSGHDIVN 221
Cdd:pfam12146 159 ADPLVHGGIS-ARTLYELlDAG--ERLLRRAAAITVPLLLLHGGADRVVDPAGSREFYERAGSTDKTLKLYPGLYHELLN 235


                  ...
gi 489828725  222 DCE 224
Cdd:pfam12146 236 EPD 238
DLH COG0412
Dienelactone hydrolase [Secondary metabolites biosynthesis, transport and catabolism];
15-113 1.60e-11

Dienelactone hydrolase [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 440181 [Multi-domain]  Cd Length: 226  Bit Score: 61.91  E-value: 1.60e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489828725  15 AVLLLHGFAGTTEDVRELGEILAENGYTVHAPNFRGHGDEP-------AIFLKTTPEMWYEDAVAGYRQLEKDGY---DE 84
Cdd:COG0412   31 GVVVLHEIFGLNPHIRDVARRLAAAGYVVLAPDLYGRGGPGddpdearALMGALDPELLAADLRAALDWLKAQPEvdaGR 110

                         90       100       110
                 ....*....|....*....|....*....|
gi 489828725  85 IAIVGVAMGGVFALKMAESFSP-KAIVPLC 113
Cdd:COG0412  111 VGVVGFCFGGGLALLAAARGPDlAAAVSFY 140
Abhydrolase_6 pfam12697
Alpha/beta hydrolase family; This family contains alpha/beta hydrolase enzymes of diverse ...
 16-222 1.51e-07

Alpha/beta hydrolase family; This family contains alpha/beta hydrolase enzymes of diverse specificity.


Pssm-ID: 463673 [Multi-domain]  Cd Length: 211  Bit Score: 50.55  E-value: 1.51e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489828725   16 VLLLHGFAGTTEDVRELgeilAENGYTVHAPNFRGHGDEPAIFLKTTPEMWYEDAVAGYRQLEKdgydeIAIVGVAMGGV 95
Cdd:pfam12697   1 VVLVHGAGLSAAPLAAL----LAAGVAVLAPDLPGHGSSSPPPLDLADLADLAALLDELGAARP-----VVLVGHSLGGA 71

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489828725   96 FALKMAE------------SFSPKAIVPLCANVNRKMRYIPIENYLTKQLKKQGIVEQEADQmlKNYLPEIDVMTEARAT 163
Cdd:pfam12697  72 VALAAAAaalvvgvlvaplAAPPGLLAALLALLARLGAALAAPAWLAAESLARGFLDDLPAD--AEWAAALARLAALLAA 149

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 489828725  164 FYKNVARDIEKIHVPTMIGQGcQDEEIDADNANYIFKHIHtndKQLCFYAGSGHDIVND 222
Cdd:pfam12697 150 LALLPLAAWRDLPVPVLVLAE-EDRLVPELAQRLLAALAG---ARLVVLPGAGHLPLDD 204
COG4188 COG4188
Predicted dienelactone hydrolase [General function prediction only];
16-217 1.78e-07

Predicted dienelactone hydrolase [General function prediction only];


Pssm-ID: 443342 [Multi-domain]  Cd Length: 326  Bit Score: 50.88  E-value: 1.78e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489828725  16 VLLLHGFAGTTEDVRELGEILAENGYTVHAPNFRGH------GDEPAIFLKTTPEMWYE---------DAVAgyrQLEKD 80
Cdd:COG4188   65 VVLSHGLGGSREGYAYLAEHLASHGYVVAAPDHPGSnaadlsAALDGLADALDPEELWErpldlsfvlDQLL---ALNKS 141

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489828725  81 GY--------DEIAIVGVAMGGVFALKMA-ESFSPKAIVPLCANVNRKMRYIPIENYLTKQLK----KQGIVeqeadqml 147
Cdd:COG4188  142 DPplagrldlDRIGVIGHSLGGYTALALAgARLDFAALRQYCGKNPDLQCRALDLPRLAYDLRdpriKAVVA-------- 213

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 489828725 148 knylpeIDvmTEARATFyknVARDIEKIHVPTMIGQGCQDEEIDA-DNANYIFKHIHTNDKQLCFYAGSGH 217
Cdd:COG4188  214 ------LA--PGGSGLF---GEEGLAAITIPVLLVAGSADDVTPApDEQIRPFDLLPGADKYLLTLEGATH 273
hydr2_PEP TIGR03101
exosortase A system-associated hydrolase 2; This group of proteins are members of the alpha ...
 12-134 1.07e-06

exosortase A system-associated hydrolase 2; This group of proteins are members of the alpha/beta hydrolase superfamily. These proteins are generally found in genomes containing the exosortase/PEP-CTERM protein expoert system, specifically the type 1 variant of this system described by the Genome Property GenProp0652. When found in this context they are invariably present in the vicinity of a second, relatively unrelated enzyme (ortholog 1, TIGR03100) of the same superfamily.


Pssm-ID: 274428  Cd Length: 266  Bit Score: 48.27  E-value: 1.07e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489828725   12 GNRAVLLLHGFAGTTEDVRE----LGEILAENGYTVHAPNFRGHGDEPAIFLKTTPEMWYEDAVAGYRQLEKDGYDEIAI 87
Cdd:TIGR03101  24 PRGVVIYLPPFAEEMNKSRRmvalQARAFAAGGFGVLQIDLYGCGDSAGDFAAARWDVWKEDVAAAYRWLIEQGHPPVTL 103

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 489828725   88 VGVAMGGVFALKMAesfspkaiVPLCANVNRKMRYIPIEN---YLTKQLK 134
Cdd:TIGR03101 104 WGLRLGALLALDAA--------NPLAAKCNRLVLWQPVVSgkqQLQQFLR 145
EstA COG1075
Triacylglycerol esterase/lipase EstA, alpha/beta hydrolase fold [Lipid transport and ...
 10-110 2.22e-06

Triacylglycerol esterase/lipase EstA, alpha/beta hydrolase fold [Lipid transport and metabolism];


Pssm-ID: 440693 [Multi-domain]  Cd Length: 106  Bit Score: 45.21  E-value: 2.22e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489828725  10 KAGNRAVLLLHGFAGTTEDVRELGEILAENGYTVHAPNFRGHG---DEPAIFLKttpemwyeDAVAgyRQLEKDGYDEIA 86
Cdd:COG1075    2 AATRYPVVLVHGLGGSAASWAPLAPRLRAAGYPVYALNYPSTNgsiEDSAEQLA--------AFVD--AVLAATGAEKVD 71

                         90       100
                 ....*....|....*....|....
gi 489828725  87 IVGVAMGGVFALKMAESFSPKAIV 110
Cdd:COG1075   72 LVGHSMGGLVARYYLKRLGGAAKV 95
DLH pfam01738
Dienelactone hydrolase family;
15-111 1.93e-05

Dienelactone hydrolase family;


Pssm-ID: 396343 [Multi-domain]  Cd Length: 213  Bit Score: 44.26  E-value: 1.93e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489828725   15 AVLLLHGFAGTTEDVRELGEILAENGYTVHAPNF-RGHGD--EPAIFLKTTPEMW-----------YEDAVAGYRQLEKD 80
Cdd:pfam01738  14 VVVVFQEIFGVNDNIREIADRLADEGYVALAPDLyFRQGDpnDEADAARAMFELVskrvmekvlddLEAAVNYLKSQPEV 93

                          90       100       110
                  ....*....|....*....|....*....|..
gi 489828725   81 GYDEIAIVGVAMGGVFALKMAESFSP-KAIVP 111
Cdd:pfam01738  94 SPKKVGVVGYCMGGALAVLLAAKGPLvDAAVG 125
PRK14875 PRK14875
acetoin dehydrogenase E2 subunit dihydrolipoyllysine-residue acetyltransferase; Provisional
 10-103 1.56e-03

acetoin dehydrogenase E2 subunit dihydrolipoyllysine-residue acetyltransferase; Provisional


Pssm-ID: 184875 [Multi-domain]  Cd Length: 371  Bit Score: 39.16  E-value: 1.56e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489828725  10 KAGNRAVLLLHGFAGTTEDVRELGEILAEnGYTVHAPNFRGHGDEPAIFLKTTPEmWYEDAVAGYrqLEKDGYDEIAIVG 89
Cdd:PRK14875 128 EGDGTPVVLIHGFGGDLNNWLFNHAALAA-GRPVIALDLPGHGASSKAVGAGSLD-ELAAAVLAF--LDALGIERAHLVG 203

                         90
                 ....*....|....
gi 489828725  90 VAMGGVFALKMAES 103
Cdd:PRK14875 204 HSMGGAVALRLAAR 217
BAAT_C pfam08840
BAAT / Acyl-CoA thioester hydrolase C terminal; This catalytic domain is found at the C ...
 66-220 3.34e-03

BAAT / Acyl-CoA thioester hydrolase C terminal; This catalytic domain is found at the C terminal of acyl-CoA thioester hydrolases and bile acid-CoA:amino acid N-acetyltransferases (BAAT).


Pssm-ID: 430252 [Multi-domain]  Cd Length: 211  Bit Score: 37.64  E-value: 3.34e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489828725   66 WYEDAVAGYRQLEKDGYDEIAIVGVAMGGVFALKMAeSFSPK-----AIVPLCANVNRKMRYIPIE-NYLTKQLKKqgiv 139
Cdd:pfam08840   5 YFEEAINYLLRHPKVKGPGIGLLGISKGGELALSMA-TFLKQitatvSINGSAVVSGDPLVYKDNPlPPLGEGMRR---- 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489828725  140 eqeaDQMLKNYLPEIDVMTEARATFYKNVAR-DIEKIHVPTMIGQGCQDEEIDADNANYIF-----KHIHTNDKQLCFYA 213
Cdd:pfam08840  80 ----IKVNKDGLLDIRDMFNDPLSKPDPKSLiPVERAKGPFLFVVGQDDHNWPSVFYAKKAcerlqKHGKEVEVQLVCYP 155


                  ....*..
gi 489828725  214 GSGHDIV 220
Cdd:pfam08840 156 GAGHLIE 162
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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