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Conserved domains on  [gi|489739092|ref|WP_003643181|]
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phosphatase PAP2 family protein [Lactiplantibacillus plantarum]

Protein Classification

phosphatase PAP2 family protein( domain architecture ID 10130261)

type 2 phosphatidic acid phosphatase (PAP2) family protein similar to Bacillus subtilis phosphatidylglycerophosphatase B that catalyzes the dephosphorylation of phosphatidylglycerophosphate (PGP) to phosphatidylglycerol

CATH:  1.20.144.10
EC:  3.1.3.-
Gene Ontology:  GO:0016020|GO:0016791|GO:1901137|GO:0006629
PubMed:  9122162
SCOP:  3001110

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PAP2_like_2 cd03392
PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This ...
 37-198 3.74e-37

PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase.


:

Pssm-ID: 239486  Cd Length: 182  Bit Score: 128.11  E-value: 3.74e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489739092  37 AVWQRAPWLTHFDTTVANFWH-HSPQWFQHAMVTYTQLGNPHTITIITLIIGLALWLGHNPRGAVFfWVTTWLIAGYGNY 115
Cdd:cd03392    1 AVVVQAGWLTAFDQSVLSLLRsLRTPLLTAFMTAITFLGSPAVLLIIVLLLALLLLLKRRRRAALF-LLLALLGGGALNT 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489739092 116 LIKQVIMRPRPTAWRLVQIGGYSYPSGHSTTTTVLIGSLLVLAFDYWHRNALTGWLTALGITAILLMMISRVIVGVHYPS 195
Cdd:cd03392   80 LLKLLVQRPRPPLHLLVPEGGYSFPSGHAMGATVLYGFLAYLLARRLPRRRVRILLLILAAILILLVGLSRLYLGVHYPS 159


                 ...
gi 489739092 196 DTI 198
Cdd:cd03392  160 DVL 162
 
Name Accession Description Interval E-value
PAP2_like_2 cd03392
PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This ...
 37-198 3.74e-37

PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase.


Pssm-ID: 239486  Cd Length: 182  Bit Score: 128.11  E-value: 3.74e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489739092  37 AVWQRAPWLTHFDTTVANFWH-HSPQWFQHAMVTYTQLGNPHTITIITLIIGLALWLGHNPRGAVFfWVTTWLIAGYGNY 115
Cdd:cd03392    1 AVVVQAGWLTAFDQSVLSLLRsLRTPLLTAFMTAITFLGSPAVLLIIVLLLALLLLLKRRRRAALF-LLLALLGGGALNT 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489739092 116 LIKQVIMRPRPTAWRLVQIGGYSYPSGHSTTTTVLIGSLLVLAFDYWHRNALTGWLTALGITAILLMMISRVIVGVHYPS 195
Cdd:cd03392   80 LLKLLVQRPRPPLHLLVPEGGYSFPSGHAMGATVLYGFLAYLLARRLPRRRVRILLLILAAILILLVGLSRLYLGVHYPS 159


                 ...
gi 489739092 196 DTI 198
Cdd:cd03392  160 DVL 162
PgpB COG0671
Membrane-associated phospholipid phosphatase [Lipid transport and metabolism]; ...
 28-198 6.89e-13

Membrane-associated phospholipid phosphatase [Lipid transport and metabolism]; Membrane-associated phospholipid phosphatase is part of the Pathway/BioSystem: Phospholipid biosynthesis


Pssm-ID: 440435 [Multi-domain]  Cd Length: 189  Bit Score: 64.68  E-value: 6.89e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489739092  28 FIGWLGWTAAVWQRAPWLTHFDTTVANFWHHSPQWFQHAMVTYTQLGNPHTITIITLIIGLALWLGHNPRGAVFFWVTT- 106
Cdd:COG0671    1 LLLALLLALLLLLLLLADLLALALLALLLLLALLLLLLLLLALLLILLLLLLLLLLLLLLLLLLLRLLALLLLLLLLAAl 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489739092 107 -WLIAGYGNYLIKQVIMRPRPTAW-----RLVQIGGYSYPSGHSTTTTVLIGSLLVLAFDYWhrnaltgwLTALGITAIL 180
Cdd:COG0671   81 lLLLLLLLLLLLKYLFGRPRPFVVpdlelLLGTAGGYSFPSGHAAAAFALALVLALLLPRRW--------LAALLLALAL 152

                        170
                 ....*....|....*...
gi 489739092 181 LMMISRVIVGVHYPSDTI 198
Cdd:COG0671  153 LVGLSRVYLGVHYPSDVL 170
PAP2 pfam01569
PAP2 superfamily; This family includes the enzyme type 2 phosphatidic acid phosphatase (PAP2), ...
 108-198 8.41e-09

PAP2 superfamily; This family includes the enzyme type 2 phosphatidic acid phosphatase (PAP2), Glucose-6-phosphatase EC:3.1.3.9, Phosphatidylglycerophosphatase B EC:3.1.3.27 and bacterial acid phosphatase EC:3.1.3.2. The family also includes a variety of haloperoxidases that function by oxidising halides in the presence of hydrogen peroxide to form the corresponding hypohalous acids.


Pssm-ID: 426329 [Multi-domain]  Cd Length: 124  Bit Score: 52.04  E-value: 8.41e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489739092  108 LIAGYGNYLIKQVIMRPRPTAWRLVQI----------GGYSYPSGHSTTTTVLIGsLLVLAFDYWHRNALTgWLTALGIT 177
Cdd:pfam01569   7 ALAGLLSSVLKDYFGRPRPFFLLLEGGlvpapstlpgLGYSFPSGHSATAFALAL-LLALLLRRLRKIVRV-LLALLLLV 84

                          90       100
                  ....*....|....*....|.
gi 489739092  178 AILLMMISRVIVGVHYPSDTI 198
Cdd:pfam01569  85 LALLVGLSRLYLGVHFPSDVL 105
acidPPc smart00014
Acid phosphatase homologues;
108-198 2.76e-08

Acid phosphatase homologues;


Pssm-ID: 214471 [Multi-domain]  Cd Length: 116  Bit Score: 50.42  E-value: 2.76e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489739092   108 LIAGYGNYL---IKQVIMRPRPTAW-----------RLVQIGGYSYPSGHSTTTTVLIGSLLVLAFDYWHRNALTGWLTA 173
Cdd:smart00014   2 LLAVVSQLFngvIKNYFGRPRPFFLsigdacctpnfLLTLEAGYSFPSGHTAFAFAFALFLLLYLPARAGRKLLIFLLLL 81

                           90       100
                   ....*....|....*....|....*
gi 489739092   174 LGitaiLLMMISRVIVGVHYPSDTI 198
Cdd:smart00014  82 LA----LVVGFSRVYLGAHWPSDVL 102
 
Name Accession Description Interval E-value
PAP2_like_2 cd03392
PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This ...
 37-198 3.74e-37

PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase.


Pssm-ID: 239486  Cd Length: 182  Bit Score: 128.11  E-value: 3.74e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489739092  37 AVWQRAPWLTHFDTTVANFWH-HSPQWFQHAMVTYTQLGNPHTITIITLIIGLALWLGHNPRGAVFfWVTTWLIAGYGNY 115
Cdd:cd03392    1 AVVVQAGWLTAFDQSVLSLLRsLRTPLLTAFMTAITFLGSPAVLLIIVLLLALLLLLKRRRRAALF-LLLALLGGGALNT 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489739092 116 LIKQVIMRPRPTAWRLVQIGGYSYPSGHSTTTTVLIGSLLVLAFDYWHRNALTGWLTALGITAILLMMISRVIVGVHYPS 195
Cdd:cd03392   80 LLKLLVQRPRPPLHLLVPEGGYSFPSGHAMGATVLYGFLAYLLARRLPRRRVRILLLILAAILILLVGLSRLYLGVHYPS 159


                 ...
gi 489739092 196 DTI 198
Cdd:cd03392  160 DVL 162
PgpB COG0671
Membrane-associated phospholipid phosphatase [Lipid transport and metabolism]; ...
 28-198 6.89e-13

Membrane-associated phospholipid phosphatase [Lipid transport and metabolism]; Membrane-associated phospholipid phosphatase is part of the Pathway/BioSystem: Phospholipid biosynthesis


Pssm-ID: 440435 [Multi-domain]  Cd Length: 189  Bit Score: 64.68  E-value: 6.89e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489739092  28 FIGWLGWTAAVWQRAPWLTHFDTTVANFWHHSPQWFQHAMVTYTQLGNPHTITIITLIIGLALWLGHNPRGAVFFWVTT- 106
Cdd:COG0671    1 LLLALLLALLLLLLLLADLLALALLALLLLLALLLLLLLLLALLLILLLLLLLLLLLLLLLLLLLRLLALLLLLLLLAAl 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489739092 107 -WLIAGYGNYLIKQVIMRPRPTAW-----RLVQIGGYSYPSGHSTTTTVLIGSLLVLAFDYWhrnaltgwLTALGITAIL 180
Cdd:COG0671   81 lLLLLLLLLLLLKYLFGRPRPFVVpdlelLLGTAGGYSFPSGHAAAAFALALVLALLLPRRW--------LAALLLALAL 152

                        170
                 ....*....|....*...
gi 489739092 181 LMMISRVIVGVHYPSDTI 198
Cdd:COG0671  153 LVGLSRVYLGVHYPSDVL 170
PAP2_like cd01610
PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, ...
 96-198 3.48e-12

PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid phosphatase, vanadium chloroperoxidases, vanadium bromoperoxidases, and several other mostly uncharacterized subfamilies. Several members of this superfamily have been predicted to be transmembrane proteins.


Pssm-ID: 238813 [Multi-domain]  Cd Length: 122  Bit Score: 61.32  E-value: 3.48e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489739092  96 PRGAVFFWVTTWLIAGYGNYLIKQVIMRPRP---------TAWRLVQIGGYSYPSGHSTTTTVLIGSLLVLAFDYWHRNa 166
Cdd:cd01610    1 RRLLALLLLLALLAGLLLTGVLKYLFGRPRPyfllrcgpdGDPLLLTEGGYSFPSGHAAFAFALALFLALLLPRRLLRL- 79

                         90       100       110
                 ....*....|....*....|....*....|..
gi 489739092 167 ltgWLTALGITAILLMMISRVIVGVHYPSDTI 198
Cdd:cd01610   80 ---LLGLLLLLLALLVGLSRVYLGVHYPSDVL 108
PAP2_like_3 cd03393
PAP2_like_3 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This ...
 96-198 3.80e-09

PAP2_like_3 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria and archaea, lacks functional characterization and may act as a membrane-associated lipid phosphatase.


Pssm-ID: 239487 [Multi-domain]  Cd Length: 125  Bit Score: 53.14  E-value: 3.80e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489739092  96 PRGAVFFWVTTwLIAGYGNYLIKQVIMRPRP-TAWRLVQI-----GGYSYPSGHSTTTTVLIGSLLVlafdywHRNalTG 169
Cdd:cd03393   12 KRLGRYLGLAL-CASGYLNAALKEVFKIPRPfTYDGIQAIyeesaGGYGFPSGHAQTSATFWGSLML------HVR--KK 82

                         90       100
                 ....*....|....*....|....*....
gi 489739092 170 WLTALGITAILLMMISRVIVGVHYPSDTI 198
Cdd:cd03393   83 WFTLIGVVLVVLISFSRLYLGVHWPSDVI 111
PAP2 pfam01569
PAP2 superfamily; This family includes the enzyme type 2 phosphatidic acid phosphatase (PAP2), ...
 108-198 8.41e-09

PAP2 superfamily; This family includes the enzyme type 2 phosphatidic acid phosphatase (PAP2), Glucose-6-phosphatase EC:3.1.3.9, Phosphatidylglycerophosphatase B EC:3.1.3.27 and bacterial acid phosphatase EC:3.1.3.2. The family also includes a variety of haloperoxidases that function by oxidising halides in the presence of hydrogen peroxide to form the corresponding hypohalous acids.


Pssm-ID: 426329 [Multi-domain]  Cd Length: 124  Bit Score: 52.04  E-value: 8.41e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489739092  108 LIAGYGNYLIKQVIMRPRPTAWRLVQI----------GGYSYPSGHSTTTTVLIGsLLVLAFDYWHRNALTgWLTALGIT 177
Cdd:pfam01569   7 ALAGLLSSVLKDYFGRPRPFFLLLEGGlvpapstlpgLGYSFPSGHSATAFALAL-LLALLLRRLRKIVRV-LLALLLLV 84

                          90       100
                  ....*....|....*....|.
gi 489739092  178 AILLMMISRVIVGVHYPSDTI 198
Cdd:pfam01569  85 LALLVGLSRLYLGVHFPSDVL 105
PAP2_lipid_A_1_phosphatase cd03389
PAP2_like proteins, Lipid A 1-phosphatase subfamily. Lipid A 1-phosphatase, or LpxE from ...
 97-198 1.42e-08

PAP2_like proteins, Lipid A 1-phosphatase subfamily. Lipid A 1-phosphatase, or LpxE from Francisella novicida selectively dephosphorylates lipid A at the 1-position. Lipid A is the membrane-anchor component of lipopolysaccharides (LPS), the major constituents of the outer membrane in many gram-negative bacteria.


Pssm-ID: 239483  Cd Length: 186  Bit Score: 52.71  E-value: 1.42e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489739092  97 RGAVFFWVTTwlIAGYGNYLIKQVIMRPRPTAwrLVQIGGY------------SYPSGHSTTTTVLIGSLLVLAFDYWHr 164
Cdd:cd03389   70 AGLFLFATVA--LSGILVNLLKFIIGRARPKL--LFDDGLYgfdpfhadyaftSFPSGHSATAGAAAAALALLFPRYRW- 144

                         90       100       110
                 ....*....|....*....|....*....|....
gi 489739092 165 naltgwltaLGITAILLMMISRVIVGVHYPSDTI 198
Cdd:cd03389  145 ---------AFILLALLIAFSRVIVGAHYPSDVI 169
acidPPc smart00014
Acid phosphatase homologues;
108-198 2.76e-08

Acid phosphatase homologues;


Pssm-ID: 214471 [Multi-domain]  Cd Length: 116  Bit Score: 50.42  E-value: 2.76e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489739092   108 LIAGYGNYL---IKQVIMRPRPTAW-----------RLVQIGGYSYPSGHSTTTTVLIGSLLVLAFDYWHRNALTGWLTA 173
Cdd:smart00014   2 LLAVVSQLFngvIKNYFGRPRPFFLsigdacctpnfLLTLEAGYSFPSGHTAFAFAFALFLLLYLPARAGRKLLIFLLLL 81

                           90       100
                   ....*....|....*....|....*
gi 489739092   174 LGitaiLLMMISRVIVGVHYPSDTI 198
Cdd:smart00014  82 LA----LVVGFSRVYLGAHWPSDVL 102
PAP2_like_4 cd03395
PAP2_like_4 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This ...
 116-198 4.58e-05

PAP2_like_4 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase.


Pssm-ID: 239489  Cd Length: 177  Bit Score: 42.64  E-value: 4.58e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489739092 116 LIKQVIMRPRPT--------AWRLVQIGGYSYPSGHSTTTTVLIgSLLVLAFdywHRNALTGWLTALGITAIllmmISRV 187
Cdd:cd03395   75 FLKPLVARLRPCnaldgvrlVVLGDQGGSYSFASSHAANSFALA-LFIWLFF---RRGLFSPVLLLWALLVG----YSRV 146

                         90
                 ....*....|.
gi 489739092 188 IVGVHYPSDTI 198
Cdd:cd03395  147 YVGVHYPGDVI 157
PAP2_SPPase1 cd03388
PAP2_like proteins, sphingosine-1-phosphatase subfamily. Sphingosine-1-phosphatase is an ...
 97-198 8.67e-05

PAP2_like proteins, sphingosine-1-phosphatase subfamily. Sphingosine-1-phosphatase is an intracellular enzyme located in the endoplasmic reticulum, which regulates the level of sphingosine-1-phosphate (S1P), a bioactive lipid. S1P acts as a second messenger in the cell, and extracellularly by binding to G-protein coupled receptors of the endothelial differentiation gene family.


Pssm-ID: 239482  Cd Length: 151  Bit Score: 41.45  E-value: 8.67e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489739092  97 RGAVFFWVTTWLIAGYgnylIKQVIMRPRPTA---WRLVQIGG---YSYPSGHSTTTTVLIGSLLVLAFDYWHRNALTGW 170
Cdd:cd03388   36 RDLVVVLALGMYIGQF----IKDLFCLPRPSSppvVRLTMSSAaleYGFPSTHAMNATAISFYLLIYLYDRYQYPFVLGL 111

                         90       100
                 ....*....|....*....|....*...
gi 489739092 171 LTALGITAilLMMISRVIVGVHYPSDTI 198
Cdd:cd03388  112 ILALFYST--LVCLSRIYMGMHSVLDVI 137
PAP2_acid_phosphatase cd03397
PAP2, bacterial acid phosphatase or class A non-specific acid phosphatases. These enzymes ...
 87-198 2.12e-04

PAP2, bacterial acid phosphatase or class A non-specific acid phosphatases. These enzymes catalyze phosphomonoester hydrolysis, with optimal activity in low pH conditions. They are secreted into the periplasmic space, and their physiological role remains to be determined.


Pssm-ID: 239491  Cd Length: 232  Bit Score: 41.17  E-value: 2.12e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489739092  87 GLALWLGHNPRGAVFFWVTTwLIAGYGNYLIKQVIMRPRPTAWRLVQI----------GGYSYPSGHSTTttvligsllv 156
Cdd:cd03397   91 SCALGEERTPELYRLLRRVL-EDAGSATYPAKKYYNRPRPFVLNDEPIctppdesglaKDGSYPSGHTAA---------- 159

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 489739092 157 lafdywhrnaltGWLTALgitaILLMMI----------------SRVIVGVHYPSDTI 198
Cdd:cd03397  160 ------------GYAWAL----ILAELVperadeilargseygqSRIVCGVHWPSDVM 201
PAP2_like_6 cd03396
PAP2_like_6 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This ...
 135-198 2.47e-03

PAP2_like_6 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which mainly contains bacterial proteins, lacks functional characterization and may act as a membrane-associated lipid phosphatase.


Pssm-ID: 239490  Cd Length: 197  Bit Score: 37.66  E-value: 2.47e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 489739092 135 GGYSYPSGHSTTTTVLIGsllvLAFDYWHRNALTGWLT-ALGITAILLMMISRVIVGVHYPSDTI 198
Cdd:cd03396  120 KGCSFPSGHASAGFALLA----LYFLFRRRRPRLARLVlAAGLALGALMGLARMARGAHFLSDVL 180
PAP2_like_1 cd03380
PAP2_like_1 proteins, a sub-family of PAP2, containing bacterial acid phosphatase, vanadium ...
 118-198 6.51e-03

PAP2_like_1 proteins, a sub-family of PAP2, containing bacterial acid phosphatase, vanadium chloroperoxidases and vanadium bromoperoxidases.


Pssm-ID: 239475  Cd Length: 209  Bit Score: 36.64  E-value: 6.51e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489739092 118 KQVIMRPRPTAWRLVQIGGY-----------SYPSGHsTTTTVLIGSLLVLAFDYwHRNALtgwltalgITAILLMMISR 186
Cdd:cd03380  113 KYHYNRPRPFVAIRLQWLPIctpeegtpkhpSYPSGH-ATFGGAAALVLAELFPE-RAAEL--------LARAAEAGNSR 182

                         90
                 ....*....|..
gi 489739092 187 VIVGVHYPSDTI 198
Cdd:cd03380  183 VVAGVHWPSDVE 194
PAP2_BcrC_like cd03385
PAP2_like proteins, BcrC_like subfamily. Several members of this family have been annotated as ...
 88-196 7.36e-03

PAP2_like proteins, BcrC_like subfamily. Several members of this family have been annotated as bacitracin transport permeases, as it was suspected that they form the permease component of an ABC transporter system. It was shown, however, that BcrC from Bacillus subtilis posesses undecaprenyl pyrophosphate (UPP) phospatase activity, and it is hypothesized that it competes with bacitracin for UPP, increasing the cell's resistance to bacitracin.


Pssm-ID: 239480  Cd Length: 144  Bit Score: 35.70  E-value: 7.36e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489739092  88 LALWLGHNP--RGAVFFWVTTWLIAGYGNYLIKQVIMRPRPTAWRLVQI-----GGYSYPSGHSTTttvligsLLVLAFD 160
Cdd:cd03385   21 VVLWLWGGEkqRKVVLFATIAVAVALLINYIIGLLYFHPRPFVVGLGHNllphaADSSFPSDHTTL-------FFSIAFS 93

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 489739092 161 YWHRNAL-TGWLTALgitAILLMMISRVIVGVHYPSD 196
Cdd:cd03385   94 LLLRRRKwAGWILLI---LALLVAWSRIYLGVHYPLD 127
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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