NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|489738493|ref|WP_003642588|]
View 

MULTISPECIES: phosphoribosylformylglycinamidine synthase subunit PurS [Lactiplantibacillus]

Protein Classification

phosphoribosylformylglycinamidine synthase subunit PurS( domain architecture ID 10496975)

phosphoribosylformylglycinamidine synthase subunit PurS catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
PurS pfam02700
Phosphoribosylformylglycinamidine (FGAM) synthase; This family forms a component of the de ...
 4-78 1.32e-34

Phosphoribosylformylglycinamidine (FGAM) synthase; This family forms a component of the de novo purine biosynthesis pathway.


:

Pssm-ID: 426932  Cd Length: 77  Bit Score: 112.50  E-value: 1.32e-34
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 489738493   4 VKIYVTYKQSILDPKGEAIHDALHRLGYTNVDAVELGKYFEVKIHADDRPVA-AEIDEMCDRLLANVNMETYRYEI 78
Cdd:pfam02700  2 AKVYVTLKPGVLDPQGEAIKRALHRLGYEGVEDVRIGKYIELELEAEDEEEAeEEVEEMCEKLLANPVIEDYEIEL 77
 
Name Accession Description Interval E-value
PurS pfam02700
Phosphoribosylformylglycinamidine (FGAM) synthase; This family forms a component of the de ...
 4-78 1.32e-34

Phosphoribosylformylglycinamidine (FGAM) synthase; This family forms a component of the de novo purine biosynthesis pathway.


Pssm-ID: 426932  Cd Length: 77  Bit Score: 112.50  E-value: 1.32e-34
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 489738493   4 VKIYVTYKQSILDPKGEAIHDALHRLGYTNVDAVELGKYFEVKIHADDRPVA-AEIDEMCDRLLANVNMETYRYEI 78
Cdd:pfam02700  2 AKVYVTLKPGVLDPQGEAIKRALHRLGYEGVEDVRIGKYIELELEAEDEEEAeEEVEEMCEKLLANPVIEDYEIEL 77
PurS COG1828
Phosphoribosylformylglycinamidine (FGAM) synthase, PurS subunit [Nucleotide transport and ...
 1-80 3.71e-32

Phosphoribosylformylglycinamidine (FGAM) synthase, PurS subunit [Nucleotide transport and metabolism]; Phosphoribosylformylglycinamidine (FGAM) synthase, PurS subunit is part of the Pathway/BioSystem: Purine biosynthesis


Pssm-ID: 441433  Cd Length: 82  Bit Score: 106.79  E-value: 3.71e-32
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489738493  1 MYLVKIYVTYKQSILDPKGEAIHDALHRLGYTNVDAVELGKYFEVKIHADDRPVA-AEIDEMCDRLLANVNMETYRYEIT 79
Cdd:COG1828   1 MFKARVEVTLKPGVLDPQGEAIKRALKRLGYEGVEDVRIGKYIELELDAEDEEEAeEEVEEICEKLLANPVIEDYEIELE 80


                .
gi 489738493 80 E 80
Cdd:COG1828  81 E 81
PRK05974 PRK05974
phosphoribosylformylglycinamidine synthase subunit PurS; Reviewed
 2-80 3.50e-30

phosphoribosylformylglycinamidine synthase subunit PurS; Reviewed


Pssm-ID: 235659  Cd Length: 80  Bit Score: 101.43  E-value: 3.50e-30
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489738493  2 YLVKIYVTYKQSILDPKGEAIHDALHRLGYTNVDAVELGKYFEVKIHADDRPVA-AEIDEMCDRLLANVNMETYRYEITE 80
Cdd:PRK05974  1 YKVKVTVTLKEGVLDPQGQAIKGALGSLGYDGVEDVRQGKYFELELEGESEEKAeADLKEMCEKLLANPVIEDYRIEIEE 80
TIGR00302 TIGR00302
phosphoribosylformylglycinamidine synthase, purS protein; In species such as Bacillus subtilis ...
 2-80 1.52e-21

phosphoribosylformylglycinamidine synthase, purS protein; In species such as Bacillus subtilis in which FGAM synthetase is split into two ORFs purL and purQ, this small protein, previously called yexA, is required for FGAM synthetase activity. Although the article does not make it clear whether this is a subunit or an accessory protein, it is encoded as part of the operon, which suggests stochiometric amounts, = subunit. [Purines, pyrimidines, nucleosides, and nucleotides, Purine ribonucleotide biosynthesis]


Pssm-ID: 129402  Cd Length: 80  Bit Score: 79.78  E-value: 1.52e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489738493   2 YLVKIYVTYKQSILDPKGEAIHDALHRLGYTNVDAVELGKYFEVKIHADDR-PVAAEIDEMCDRLLANVNMETYRYEITE 80
Cdd:TIGR00302  1 YKVEVYIRLKKGVLDPEGAAIQRALALLGYNEVKDVRTGKVIELTIEADSEeAVEREVEEMCEKLLANPVIHDYDIEIEE 80
 
Name Accession Description Interval E-value
PurS pfam02700
Phosphoribosylformylglycinamidine (FGAM) synthase; This family forms a component of the de ...
 4-78 1.32e-34

Phosphoribosylformylglycinamidine (FGAM) synthase; This family forms a component of the de novo purine biosynthesis pathway.


Pssm-ID: 426932  Cd Length: 77  Bit Score: 112.50  E-value: 1.32e-34
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 489738493   4 VKIYVTYKQSILDPKGEAIHDALHRLGYTNVDAVELGKYFEVKIHADDRPVA-AEIDEMCDRLLANVNMETYRYEI 78
Cdd:pfam02700  2 AKVYVTLKPGVLDPQGEAIKRALHRLGYEGVEDVRIGKYIELELEAEDEEEAeEEVEEMCEKLLANPVIEDYEIEL 77
PurS COG1828
Phosphoribosylformylglycinamidine (FGAM) synthase, PurS subunit [Nucleotide transport and ...
 1-80 3.71e-32

Phosphoribosylformylglycinamidine (FGAM) synthase, PurS subunit [Nucleotide transport and metabolism]; Phosphoribosylformylglycinamidine (FGAM) synthase, PurS subunit is part of the Pathway/BioSystem: Purine biosynthesis


Pssm-ID: 441433  Cd Length: 82  Bit Score: 106.79  E-value: 3.71e-32
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489738493  1 MYLVKIYVTYKQSILDPKGEAIHDALHRLGYTNVDAVELGKYFEVKIHADDRPVA-AEIDEMCDRLLANVNMETYRYEIT 79
Cdd:COG1828   1 MFKARVEVTLKPGVLDPQGEAIKRALKRLGYEGVEDVRIGKYIELELDAEDEEEAeEEVEEICEKLLANPVIEDYEIELE 80


                .
gi 489738493 80 E 80
Cdd:COG1828  81 E 81
PRK05974 PRK05974
phosphoribosylformylglycinamidine synthase subunit PurS; Reviewed
 2-80 3.50e-30

phosphoribosylformylglycinamidine synthase subunit PurS; Reviewed


Pssm-ID: 235659  Cd Length: 80  Bit Score: 101.43  E-value: 3.50e-30
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489738493  2 YLVKIYVTYKQSILDPKGEAIHDALHRLGYTNVDAVELGKYFEVKIHADDRPVA-AEIDEMCDRLLANVNMETYRYEITE 80
Cdd:PRK05974  1 YKVKVTVTLKEGVLDPQGQAIKGALGSLGYDGVEDVRQGKYFELELEGESEEKAeADLKEMCEKLLANPVIEDYRIEIEE 80
TIGR00302 TIGR00302
phosphoribosylformylglycinamidine synthase, purS protein; In species such as Bacillus subtilis ...
 2-80 1.52e-21

phosphoribosylformylglycinamidine synthase, purS protein; In species such as Bacillus subtilis in which FGAM synthetase is split into two ORFs purL and purQ, this small protein, previously called yexA, is required for FGAM synthetase activity. Although the article does not make it clear whether this is a subunit or an accessory protein, it is encoded as part of the operon, which suggests stochiometric amounts, = subunit. [Purines, pyrimidines, nucleosides, and nucleotides, Purine ribonucleotide biosynthesis]


Pssm-ID: 129402  Cd Length: 80  Bit Score: 79.78  E-value: 1.52e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489738493   2 YLVKIYVTYKQSILDPKGEAIHDALHRLGYTNVDAVELGKYFEVKIHADDR-PVAAEIDEMCDRLLANVNMETYRYEITE 80
Cdd:TIGR00302  1 YKVEVYIRLKKGVLDPEGAAIQRALALLGYNEVKDVRTGKVIELTIEADSEeAVEREVEEMCEKLLANPVIHDYDIEIEE 80
PRK06423 PRK06423
phosphoribosylformylglycinamidine synthase; Provisional
 5-77 1.08e-05

phosphoribosylformylglycinamidine synthase; Provisional


Pssm-ID: 102368  Cd Length: 73  Bit Score: 39.49  E-value: 1.08e-05
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 489738493  5 KIYVTYKQSILDPKGEAIHDALHRLGYTNVDAVELGKYFEvkIHADDRpvaAEIDEMCDRLLANVNMETYRYE 77
Cdd:PRK06423  4 KVEVTYKPGVEDPEALTILKNLNILGYNGIKGVSISKVYY--FDADSY---NEVDEIAGKILTNPVIHSYKIE 71
PRK05783 PRK05783
hypothetical protein; Provisional
 1-57 4.64e-05

hypothetical protein; Provisional


Pssm-ID: 235606  Cd Length: 84  Bit Score: 37.79  E-value: 4.64e-05
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 489738493  1 MYLVKIYVTYKQSILDPKGEAIHDALHRLGYTNVDAVELGKYFEVKIHADDRPVAAE 57
Cdd:PRK05783  2 KYYVELIIINKDSVRDPEGETIQRYVIERYTGNIIEVRAGKYLVFKIEANSPEEAKE 58
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH