|
Name |
Accession |
Description |
Interval |
E-value |
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
11-377 |
5.94e-82 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 255.55 E-value: 5.94e-82
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489738235 11 LFALAISAFAIGSTEFISVGLMPLLVSNFHINLAQAGLTVSIYAIGIMIGAPVMTLLTGRLNRHRLMMLIMILFIIGNLL 90
Cdd:cd17324 1 LLALALAAFAIGTTEYVIQGLLPDIARDFGVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489738235 91 AASAPTFGVLLAGRVVAALAHGIFMTVASVIAADVVAPAKRASAIAIMFTGLTVATVTGVPLGTMIGQLGGWRWSFIFIS 170
Cdd:cd17324 81 AALAPSFALLLLARALAGLAHGGFWAIAAAYAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLGWRAAFLAIA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489738235 171 MIGVIGLLADYWLIPRNLPLPSKAT--VRGIIRVLTNPQLLFALLVTALGYGGTFVVYTYLSPLLEQQMHWSASAVVLIL 248
Cdd:cd17324 161 VLALLAALLLWRLLPSLPPKKPGSLglLSSLLLLLRNPRLRLAYLITFLLFGGFFALYTYLAPFLTDVPGFSSSAIIGLL 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489738235 249 VVYGLMVALGNTLGGRWANARPLIALFKMFSGLLITLLILSVTGYSHWLGLLTVLLMGIFAFMNVPGLQLYIVQLAEQNT 328
Cdd:cd17324 241 LLFGVAGVVGSPLAGRLADRGGRRALLIALLLLAAALLLLTLLGPSPLLLLVGLVLWGLGFFAAHSALQTRVLRLAPEAR 320
|
330 340 350 360
....*....|....*....|....*....|....*....|....*....
gi 489738235 329 phdiTMASALNISAFNVGIALGSGIGGQVTTNLGLGWTPIFGAIMVAVS 377
Cdd:cd17324 321 ----GLASSLYLAAYNLGGALGAALGGLVLDHGGWAGVGWVGAALLLLA 365
|
|
| PRK03545 |
PRK03545 |
putative arabinose transporter; Provisional |
9-377 |
5.30e-55 |
|
putative arabinose transporter; Provisional
Pssm-ID: 179591 [Multi-domain] Cd Length: 390 Bit Score: 186.25 E-value: 5.30e-55
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489738235 9 WTLFALAISAFAIGSTEFISVGLMPLLVSNFHINLAQAGLTVSIYAIGIMIGAPVMTLLTGRLNRHRLMMLIMILFIIGN 88
Cdd:PRK03545 9 LRVVTLALAAFIFNTTEFVPVGLLSDIAQSFHMQTAQVGLMLTIYAWVVALMSLPLMLLTSNVERRKLLIGLFVLFIASH 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489738235 89 LLAASAPTFGVLLAGRVVAALAHGIFMTVASVIAADVVAPAKRASAIAIMFTGLTVATVTGVPLGTMIGQLGGWRWSFIF 168
Cdd:PRK03545 89 VLSALAWNFTVLLISRIGIAFAHAIFWSITASLAIRVAPAGKKAQALSLLATGTALAMVLGLPLGRVIGQYLGWRTTFLA 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489738235 169 ISMIGVIGLLADYWLIPrNLPLPSKATVRGIIRVLTNPQLLFALLVTALGYGGTFVVYTYLSPLLEQQMHWSASAVVLIL 248
Cdd:PRK03545 169 IGGGALITLLLLIKLLP-LLPSEHSGSLKSLPLLFRRPALVSLYLLTVVVVTAHFTAYSYIEPFVQQVAGLSENFATLLL 247
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489738235 249 VVYGLMVALGNTLGGRWANARPLIALFKMFSGLLITLLILSVTGYSHWLGLLTVLLMGIFAFMNVPGLQLYIVQLAeqnt 328
Cdd:PRK03545 248 LLFGGAGIIGSVLFSRLGNRHPSGFLLIAIALLLVCLLLLLPAANSEWHLSVLSIFWGIAIMCIGLAMQVKVLKLA---- 323
|
330 340 350 360
....*....|....*....|....*....|....*....|....*....
gi 489738235 329 PHDITMASALNISAFNVGIALGSGIGGQVTTNLGLGWTPIFGAIMVAVS 377
Cdd:PRK03545 324 PDATDVAMALFSGIFNIGIGAGALLGNQVSLHLGLSSIGYVGAALALAA 372
|
|
| PRK10091 |
PRK10091 |
MFS transport protein AraJ; Provisional |
10-365 |
4.58e-48 |
|
MFS transport protein AraJ; Provisional
Pssm-ID: 182234 [Multi-domain] Cd Length: 382 Bit Score: 167.96 E-value: 4.58e-48
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489738235 10 TLFALAISAFAIGSTEFISVGLMPLLVSNFHINLAQAGLTVSIYAIGIMIGAPVMTLLTGRLNRHRLMMLIMILFIIGNL 89
Cdd:PRK10091 4 VILSLALGTFGLGMAEFGIMGVLTELAHDVGISIPAAGHMISYYALGVVVGAPIIALFSSRYSLKHILLFLVALCVIGNA 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489738235 90 LAASAPTFGVLLAGRVVAALAHGIFMTVASVIAADVVAPAKRASAIAIMFTGLTVATVTGVPLGTMIGQLGGWRWSFIFI 169
Cdd:PRK10091 84 MFTLSSSYLMLAIGRLVSGFPHGAFFGVGAIVLSKIIKPGKVTAAVAGMVSGMTVANLLGIPLGTYLSQEFSWRYTFLLI 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489738235 170 SMIGVIGLLADYWLIPrNLPLPSKATVRGIIRVLTNPQLLFALLVTALGYGGTFVVYTYLSPLLEQQMHWSASAVVLILV 249
Cdd:PRK10091 164 AVFNIAVLASIYFWVP-DIRDEAKGGLREQFHFLRSPAPWLIFAATMFGNAGVFAWFSYIKPYMMFISGFSETSMTFIMM 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489738235 250 VYGLMVALGNTLGGRWANARPLIALFKMFSGLL-ITLLILSVTGYSHWLGLLTVLL--MGIFAfMNVPgLQLYIVQLAEQ 326
Cdd:PRK10091 243 LVGLGMVLGNLLSGRLSGRYSPLRIAAVTDFIIvLALLMLFFFGGMKTASLIFAFIccAGLFA-LSAP-LQILLLQNAKG 320
|
330 340 350
....*....|....*....|....*....|....*....
gi 489738235 327 NTphdiTMASALNISAFNVGIALGSGIGGQVTTnLGLGW 365
Cdd:PRK10091 321 GE----LLGAAGGQIAFNLGSAIGAYCGGMMLT-LGLAY 354
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
2-349 |
2.15e-43 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 154.36 E-value: 2.15e-43
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489738235 2 TKQFNPSWTLFALAISAFAIGSTEFISVGLMPLLVSNFHINLAQAGLTVSIYAIGIMIGAPVMTLLTGRLNRHRLMMLIM 81
Cdd:COG2814 3 ATPRRRWLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGL 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489738235 82 ILFIIGNLLAASAPTFGVLLAGRVVAALAHGIFMTVASVIAADVVAPAKRASAIAIMFTGLTVATVTGVPLGTMIGQLGG 161
Cdd:COG2814 83 LLFALGSLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFG 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489738235 162 WRWSFIFISMIGVIGLLADYWLIPRNLPLPSKATVRGIIRVLTNPQLLFALLVTALGYGGTFVVYTYLSPLLEQQMHWSA 241
Cdd:COG2814 163 WRWVFLVNAVLALLALLLLLRLLPESRPAARARLRGSLRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSA 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489738235 242 SAVVLILVVYGLMVALGNTLGGRWANARPLIALFKMFSGLLITLLILSVTGYSHWLGLLTVLLMGIFAFMNVPGLQLYIV 321
Cdd:COG2814 243 SAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALGLLLLALAGSLWLLLLALFLLGFGFGLLFPLLQALVA 322
|
330 340
....*....|....*....|....*...
gi 489738235 322 QLAeqnTPHDITMASALNISAFNVGIAL 349
Cdd:COG2814 323 ELA---PPEARGRASGLYNSAFFLGGPL 347
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
14-377 |
3.60e-29 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 116.52 E-value: 3.60e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489738235 14 LAISAFAIGSTEFISVGLMPLLVSNFHINLAQAGLTVSIYAIGIMIGAPVMTLLTGRLNRHRLMMLIMILFIIGNLLAAS 93
Cdd:cd17325 1 LSLALFLDMLGYGIIIPILPLYAESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489738235 94 APTFGVLLAGRVVAALAHGIFMTVASVIAADVVAPAKRASAIAIMFTGLTVATVTGVPLGTMIGQLGGWRWSFIFISMIG 173
Cdd:cd17325 81 ATSYWQLLLARFLQGLASAAVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLVCAALA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489738235 174 VIGLLADYWLIPRNLPLPSKATVR------GIIRVLTNPQLLFALLVTALGYGGTFVVYTYLSPLLEQQMHWSASAVVLI 247
Cdd:cd17325 161 LLALVLALLLLPEPRPPPNKRAVSaarlrsGLRLLLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQIGLL 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489738235 248 LVVYGLMVALGNTLGGRWA---NARPLIALFKMFSGLLITLLILSVtgySHWLGLLTVLLMGIFAFMNVPGLQLYIVQLA 324
Cdd:cd17325 241 FGAQGLASALSQPPAGKLSdriGRKPLILIGLLLSAVALLLLPLAT---SFWLLLLLLALLGLGLGLVFPATLALLADIV 317
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|...
gi 489738235 325 eqnTPHDITMASALNISAFNVGIALGSGIGGQVTTNLGLGWTPIFGAIMVAVS 377
Cdd:cd17325 318 ---PPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAFGFATPFLAAAALLLLA 367
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
9-376 |
1.11e-25 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 106.89 E-value: 1.11e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489738235 9 WTLFALAISAFAIGStefISVGLMPLLVSNFHINLAQAGLTVSIYAIGIMIGAPVMTLLTGRLNRHRLMMLIMILFIIGN 88
Cdd:cd17474 2 YAVFFATLLAVLGVS---IVDPILPAIAEALGASPAQVGLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGG 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489738235 89 LLAASAPTFGVLLAGRVVAALAHGIFMTVASVIAADVVAPAKRASAIAIMFTGLTVATVTGVPLGTMIGQLgGWRWSFIF 168
Cdd:cd17474 79 LLCGLSDSFALLLAGRALQGIGAAGLGPLALTLIGDLFEGGERAKAMGLYEAALGLGIAVGPLLGGLLAAI-SWRYPFFL 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489738235 169 ISMIGVIGLLADYWLIPRNL---PLPSKATVRGIIRVLTNPQLLFALLVTALGYGGTFVVYTYLSPLLEQQMHWSASAVV 245
Cdd:cd17474 158 LAALIPVAFLAILFLLPEPKekaKSSSATKLRDLKKALRGRGLLTFLVSAFLYFFLYFAFLTYLPFLLELLYGISPIIIG 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489738235 246 LILVVYGLMVALGNTLGGRWANARpLIALFKMFSGLLITLLILSVTGYSH--WLGLLTVLLMGIFAFMNVPGLQLYIVQL 323
Cdd:cd17474 238 LLFAGWSVLLALGSLFVGRLLKKR-FGARRILVIGLLLYALSLLLLGFVPslALLLIAIVLFGLGLGLNLPLLTTLVTEL 316
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|...
gi 489738235 324 AEqntPHDITMASALNISAFNVGIALGSGIGGQVTTNLGLGWTPIFGAIMVAV 376
Cdd:cd17474 317 AP---EEERGTASSLYNFVRFLGQAVGPLLFGLLLEIFGLSAPFLVGAAIALA 366
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
9-377 |
4.61e-25 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 104.95 E-value: 4.61e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489738235 9 WTLFALAISAFAIGSTEFISVG-LMPLLVSNFHINLAQAGLTVSIYAIGIMIGAPVMTLLTGRLNRHRLMMLIMILFIIG 87
Cdd:COG2271 9 WRILALLFLAYFLNYLDRSNLSvAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGLA 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489738235 88 NLLAASAPTFGVLLAGRVVAALAHGIFMTVASVIAADVVAPAKRASAIAIMFTGLTVATVTGVPLGTMIGQLGGWRWSFI 167
Cdd:COG2271 89 TLLFGFATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAAFGWRAAFL 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489738235 168 FISMIGVIGLLADYWLIprnlplpskatvrgiirvltnpqllfaLLVTALGYGGTFVVYTYLSPLLEQQMHWSASAVVLI 247
Cdd:COG2271 169 ILGLPGLLLALLRFWLL---------------------------ALAYFLVYFALYGFLTWLPTYLVEVRGLSLAQAGLL 221
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489738235 248 LVVYGLMVALGNTLGGRWANARPLIALFKMFSGLLITLLILSVTGYSHWLGLLtVLLMGIFAFMNVPGLQLYIVQLAEQN 327
Cdd:COG2271 222 LSLPFLAGIVGSLLGGWLSDRLGRRRKLVLAIGLLLAALALLLLALLPSPALA-IALLFLAGFGLGGAFGLLWALAAELF 300
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|
gi 489738235 328 TPHDITMASALNISAFNVGIALGSGIGGQVTTNLGLGWTPIFGAIMVAVS 377
Cdd:COG2271 301 PKKARGTASGLVNTFGFLGGALGPLLVGYLLDATGYQAAFLLLAALALLA 350
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
32-377 |
1.21e-24 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 103.83 E-value: 1.21e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489738235 32 MPLLVSNFHINLAQAGLTVSIYAIGIMIGAPVMTLLTGRLNRHRLMMLIMILFIIGNLLAASAPTFGVLLAGRVVAALAH 111
Cdd:cd17489 19 LPLYAHDLGGSEAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLLATSVALLLVLRLIHGIGW 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489738235 112 GIFMTVASVIAADVVAPAKRASAIAIMFTGLTVATVTGVPLGTMIGQLGGWRWSFIFISMIGVIGLLAdYWLIPRNLPLP 191
Cdd:cd17489 99 GAFTTAAATLVADIIPPSRRGEGIGYYGLATTLAMALGPALGLFLYQHLGFAVLFIVAAVLALLALLL-VFLVKDPPPVA 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489738235 192 SKATVRGII--RVLTNPQLLFALLVTALGYGGTFVVYTYLSPLLEQQMHWSASavvLILVVYGLMVALGNTLGGRWANAR 269
Cdd:cd17489 178 AEEAEAGTRafRRLVEKKVLPPALILFLASIAYGAISTFLPLYAAERGISNAG---LFFTVYAIALLLSRPFSGKLSDRK 254
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489738235 270 PLIALFKMFSGLLITLLILSVTGYSHWLGLLTVLLMGIFAFMNVPGLQLYIVQLAEqntPHDITMASALNISAFNVGIAL 349
Cdd:cd17489 255 GPKTVIIPGLLLLALGLLLLSFAGSPWMLLLAAVLYGLGFGLLFPALQALAVDLVP---PHRRGAANGTFFIFFDLGIGL 331
|
330 340
....*....|....*....|....*...
gi 489738235 350 GSGIGGQVTTNLGLGWTPIFGAIMVAVS 377
Cdd:cd17489 332 GGLLLGLVAELFGYRAMFLLAAVVVLLA 359
|
|
| MFS_MdfA_MDR_like |
cd17320 |
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ... |
11-376 |
3.17e-22 |
|
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340878 [Multi-domain] Cd Length: 379 Bit Score: 97.26 E-value: 3.17e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489738235 11 LFALAISAFAIGSTEFISVGLmPLLVSNFHINLAQAGLTVSIYAIGIMIGAPVMTLLTGRLNRHRLMMLIMILFIIGNLL 90
Cdd:cd17320 2 LLLALLVALGPLAIDMYLPAL-PAIARDLGASASAVQLTLSAYLLGFALGQLLYGPLSDRFGRRPVLLAGLLLFILASLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489738235 91 AASAPTFGVLLAGRVVAALAHGIFMTVASVIAADVVAPAKRASAIAIMFTGLTVATVTGVPLGTMIGQLGGWRWSFIFIS 170
Cdd:cd17320 81 CALASSIEQLLIARFLQGLGAAAGSVVARAIVRDLYSGAELAKIFSLLMMILAIAPALAPLLGGLLLLFFGWRAIFVFLA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489738235 171 MIGVIGLLADYWLIPRNLP-----LPSKATVRGIIRVLTNPQLLFALLVTALGYGGTFVVYTYLSPLLEQQMHWSASAVV 245
Cdd:cd17320 161 LLGLLLLLLVLLFLPETLPeekrkPLLSSLLRAYKRVLKNRRFLGYALALGLSFAGLFAYLAAAPFIYIEQLGLSPAQFG 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489738235 246 LILVVYGLMVALGNTLGGRWANAR--PLIALFKMFSGLLITLLILSVTGYSHWLGLLTVLLMGIFAFMNvpGLQLYIVQ- 322
Cdd:cd17320 241 LLFALNAIALILGSLLNGRLVRRFgpRRLLRLGLLLLLAAALVLLLAALLGGLSLWPLVAPLFLIFFGF--GLIFPNATs 318
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....
gi 489738235 323 LAEQNTPHDITMASALNISAFNVGIALGSGIGGQVttnLGLGWTPIFGAIMVAV 376
Cdd:cd17320 319 LALEPFPHVAGTASALLGFLQFLIGALAGALVGLL---PNGTALPMGLLILVLG 369
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
14-351 |
4.83e-22 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 95.95 E-value: 4.83e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489738235 14 LAISAFAIGSTEFISVGLMPLLVS-NFHINLAQAGLTVSIYAIGIMIGAPVMTLLTGRLNRHRLMMLIMILFIIGNLLAA 92
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALPLLLAeDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489738235 93 SAPTFGVLLAGRVVAALAHGIFMTVASVIAADVVAPAKRASAIAIMFTGLTVATVTGVPLGTMIGQLGGWRWSFIFISMI 172
Cdd:pfam07690 81 FASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAIL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489738235 173 GVIGLLADYWLIP-----RNLPLPSKATVRGIIRVLTNPQLLFALLVTALGYGGTFVVYTYLSPLLEQQMHWSASAVVLI 247
Cdd:pfam07690 161 SLLAAVLLLLPRPppeskRPKPAEEARLSLIVAWKALLRDPVLWLLLALLLFGFAFFGLLTYLPLYQEVLGLSALLAGLL 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489738235 248 LVVYGLMVALGNTLGGRWA---NARPLIALFKMFSGLLITLLILSVTGYSHWLGLLTVLLMGIFAFMNVPGLQLYIVQLA 324
Cdd:pfam07690 241 LGLGGLLGAIGRLLLGRLSdrlGRRRRLLLALLLLILAALGLLLLSLTLSSLWLLLALLLLGFGFGLVFPALNALVSDLA 320
|
330 340
....*....|....*....|....*..
gi 489738235 325 eqnTPHDITMASALNISAFNVGIALGS 351
Cdd:pfam07690 321 ---PKEERGTASGLYNTAGSLGGALGP 344
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
32-361 |
1.17e-21 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 95.32 E-value: 1.17e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489738235 32 MPLLVSNFHINLAQAGLTVSIYAIGIMIGAPVMTLLTGRLNRHRLMMLIMILFIIGNLLAASAPTFGVLLAGRVVAALAH 111
Cdd:cd17321 19 LPTIARDLGASPSQLQWVVNAYLLAFAALLLLAGRLGDRFGRKRVFLIGLALFGLASLLCALAPSLAFLIAARALQGIGA 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489738235 112 GIFMTVASVIAADVVAPAKRASAIAIMFTGLTVATVTGVPLGTMIGQLGGWRWSFIFISMIGVIGLLAdywliprnlplp 191
Cdd:cd17321 99 AAIMPASLALIAATFPGERRGRALGLWGAVVGIGAALGPLLGGLLLELFGWRWIFLINVPIGLVALLL------------ 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489738235 192 skatvrgiirvltNPQLLFALLVTALGYGGTFVVYTYLSPLLEQQMHWSASAVVLILVVYGLMVALGNTLGGRWAN---A 268
Cdd:cd17321 167 -------------ARTFSGAVLAAFLLGAALGGLLFLLPLYLQGVLGYSPLQAGLALLPLALAMLVAAPLAGRLADrfgP 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489738235 269 RPLIALFKMFSGLLITLLILSVTGYSHWLGLLTVLLMGIFAFMNVPGLQLYIVQLAEqntPHDITMASALNISAFNVGIA 348
Cdd:cd17321 234 RLVLVAGLLLTAVGLLLLALLGADSSVWLLLPGLVLLGLGLGLFATPLTNAALSSVP---KEKAGAASGILNTARQLGGA 310
|
330
....*....|...
gi 489738235 349 LGSGIGGQVTTNL 361
Cdd:cd17321 311 LGVALLGALLTAG 323
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
9-392 |
4.33e-21 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 93.79 E-value: 4.33e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489738235 9 WTLFALAISAFAIGSTEFISVG-LMPLLVSNFHINLAQAGLTVSIYAIGIMIGAPVMTLLTGRLNRHRLMMLIMILFIIG 87
Cdd:COG2223 4 WRVLLLATLAFFLAFGVWYLWSvLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIG 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489738235 88 NLLAASAPTFGVLLAGRVVAALAHGIFMTVASVIAADVVAPAKRASAIAIMFTGLTVATVTGVPLGTMIGQLGGWRWSFI 167
Cdd:COG2223 84 LLLLALAVSYWLLLLLGLLLGIGGGGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGWRNAFL 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489738235 168 FISMIGVIGLLADYWLI---PRNLPLPSKATVRGIIRVLTNPQLLFALLVTALGYGGTFVVYTYLSPLLEQQMHWSASAV 244
Cdd:COG2223 164 ILGILLLVVAVLAWLFLrdpPAGAAAAAKASLRDQLEALRDPRFWLLSLLYFGTFGSFIGFSSWLPPYLVDQFGLSAATA 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489738235 245 VLILVVYGLMVALGNTLGGRWAN-ARPLIALFKMFSGLLITLLILSVTGYSHWLGLLTVLLMGIFAFMnvpGLQLYIVQL 323
Cdd:COG2223 244 GLLAALFALLGALGRPLGGWLSDrIGGRRVLLIVFALMALGLLLLALALGSLWLFLVLFLLLGLALGG---GNGAVFALV 320
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 489738235 324 AEQNTPHDITMASALNISAFNVGIALGSGIGGQVTTNLGlGWTPIFGAIMVAVSLVLLLGLIWLARPAK 392
Cdd:COG2223 321 PDIFPTKNAGAVYGLVGAAGGLGGFLGPLLFGALLDATG-SYTAAFLVFAVLALVALVLTLLLYRRPRR 388
|
|
| nepI |
PRK10213 |
purine ribonucleoside efflux pump NepI; |
7-363 |
7.32e-21 |
|
purine ribonucleoside efflux pump NepI;
Pssm-ID: 182309 [Multi-domain] Cd Length: 394 Bit Score: 93.44 E-value: 7.32e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489738235 7 PSWT-LFALAISAFAIGSTEFISVGLMPLLVSNFHINLAQAGLTVSIYAIGIMIGAPVMTLLTGRLNRHRLMMLIMILFI 85
Cdd:PRK10213 17 PNWSaVFSVAFCVACLIIVEFLPVSLLTPMAQDLGISEGVAGQSVTVTAFVAMFASLFITQTIQATDRRYVVILFAVLLT 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489738235 86 IGNLLAASAPTFGVLLAGRVVAALAHGIFMTVASVIAADVVAPAKRASAIAIMFTGLTVATVTGVPLGTMIGQLGGWRWS 165
Cdd:PRK10213 97 LSCLLVSFANSFSLLLIGRACLGLALGGFWAMSASLTMRLVPPRTVPKALSVIFGAVSIALVIAAPLGSFLGELIGWRNV 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489738235 166 FifiSMIGVIGLLADYWLIPR--NLPLPSKATVRGIIRVLTNPQLLFALLVTALGYGGTFVVYTYLSPLLEQQMHWSASA 243
Cdd:PRK10213 177 F---NAAAVMGVLCIFWIIKSlpSLPGEPSHQKQNTFRLLQRPGVMAGMIAIFMSFAGQFAFFTYIRPVYMNLAGFGVDG 253
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489738235 244 VVLILVVYGLMVALGNTLGGRWANARPLIALFKMFSGLLITLLILSVTGYSHWLGLLTVLLMGiFAFMNVP-GLQLYIVQ 322
Cdd:PRK10213 254 LTLVLLSFGIASFVGTSLSSFILKRSVKLALAGAPLVLAVSALVLTLWGSDKIVATGVAIIWG-LTFALVPvGWSTWITR 332
|
330 340 350 360
....*....|....*....|....*....|....*....|..
gi 489738235 323 -LAEQNTPhditmASALNISAFNVGIALGSGIGGQVTTNLGL 363
Cdd:PRK10213 333 sLADQAEK-----AGSIQVAVIQLANTCGAAIGGYALDNIGL 369
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
32-360 |
1.17e-19 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 89.56 E-value: 1.17e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489738235 32 MPLLVSNFHINLAQAGLTVSIYAIGIMIGAPVMTLLTGRLNRHRLMMLIMILFIIGNLLAASAPTFGVLLAGRVVAALAH 111
Cdd:cd17503 19 LPTIMGDLGASLDTVQWVITSYLLALAIMIPLSGWLADRFGTRRLFLTALALFTLGSLLCGLAPNLASLIIFRILQGFGG 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489738235 112 GIFMTVASVIAADVVAPAKRASAIAIMFTGLTVATVTGVPLGTMIGQLGGWRWSFIFISMIGVIGLLAdywliprnLPLP 191
Cdd:cd17503 99 GVLIPLAQTILLRIYPPEKRGAAMGLVGLVILLAPAIGPTLGGWLTDNLSWRWIFYINLPIGILALLL--------APLL 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489738235 192 SkatvrgiIRVLTNPQLLFALLVTALGYGGTFVVYTYLSPLLEQQMHWSASAVVLILVVYGLMVALGNTLGGR---WANA 268
Cdd:cd17503 171 D-------LRLFKDRNFTLGLLLSFLLGLGLFGAMFLLPLYLQNVLGYSAFESGLVLAPGGLASAILSPLVGRlldKFGP 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489738235 269 RPLIAL-FKMFSGLLITLLILSVTGYSHWLGLLTVLLMGIFAFMNVPGLQLYIVQLAEQNTPHditmASALNISAFNVGI 347
Cdd:cd17503 244 RLLLLAgLLLLALGTLLLAFLTPDTSLWLIILPLFIRGLGMGLVFMPLNTLALNSLPPEQIGD----ATALFNTIRQLGG 319
|
330
....*....|...
gi 489738235 348 ALGSGIGGQVTTN 360
Cdd:cd17503 320 SIGTALLATLLTN 332
|
|
| MFS_MMR_MDR_like |
cd17504 |
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ... |
14-360 |
5.24e-19 |
|
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341047 [Multi-domain] Cd Length: 371 Bit Score: 87.63 E-value: 5.24e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489738235 14 LAISAFAIGSTEFISVGLMPLLVSNFHINLAQAGLTVSIYAIGIMIGAPVMTLLTGRLNRHRLMMLIMILFIIGNLLAAS 93
Cdd:cd17504 1 LALAALAVMLVETMLSPALPTIQREFGTSAAAVSWVLTAYLLVGAVSTPILGRLGDLYGRKKVLLIVLAIYTAGSLLAAF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489738235 94 APTFGVLLAGRVVAALAHGIFmTVASVIAADVVAPAKRASAIAIMFTGLTVATVTGVPLGTMIGQLGGWRWSFIFISMIG 173
Cdd:cd17504 81 APNLPVLIAGRALQGIGGAVF-PLAFALVREEFPPERVPVAQGILSATFGIGAGIGLPLGGWIVQHLGWRWIFWTAAPVA 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489738235 174 VIGLLAdywliprnLPLPSkatvrgiIRVLTNPQLLFALLVTALGYGGTFVVYtYLSPLLEQQMHW-----SASAVVLIL 248
Cdd:cd17504 160 VLLAAL--------VPLID-------LRLLRRRNVLLANITALLAGFGMFMVF-QLLPQLLQLPTPtgfglGITEAGLLL 223
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489738235 249 VVYGLMVALGNTLGGRWANAR-PLIALFKMFSGLLITLLILSVTGYSHWLGLLTVLLMGI-FAFMNVPGLQLYIVQLAEQ 326
Cdd:cd17504 224 LPGALVMLIAGPLAGRLIARVgPRRVLLIGLVISAVGLLLLALLHSSLWALVVALLLIGIgLGLAFASLPNIVVESVPPD 303
|
330 340 350
....*....|....*....|....*....|....
gi 489738235 327 NTphdiTMASALNISAFNVGIALGSGIGGQVTTN 360
Cdd:cd17504 304 RT----GIATGMNTVLRTIGSAIGPAIAGAILTT 333
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
9-376 |
2.96e-18 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 85.68 E-value: 2.96e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489738235 9 WTLFALAISAFAIGSTEFISVG-LMPLLVSNFHINLAQAGLTVSIYAIGIMIGAPVMTLLTGRLNRHRLMMLIMILFIIG 87
Cdd:COG0738 7 RRALIAIYLLFFLWGFATALWGpLIPALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMALG 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489738235 88 NLLAASAPTFGVLLAGRVVAALAHGIFMTVASVIAADVVaPAKRASAIAIMFTGLTVATVTGVPLGT-MIGQLGGWRWSF 166
Cdd:COG0738 87 LLLFALAPSYPLLLLALFLLGLGLGLLDVAANPYVAALG-PETAASRLNLLHAFFSLGALLGPLLGGlLILLGLSLSWHL 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489738235 167 IFISMIGVIGLLAdYWLIPRNLPLPSK------ATVRGIIRVLTNPQLLFALLVTALGYGGTFVVYTYLSPLLEQQMHWS 240
Cdd:COG0738 166 PYLILAVLLLLLA-LLFLRSKLPEIEEeeeeaaGSAASLKSLLKNPRLLLGGLAIFLYVGAEGAIGDWLPLYLKDVLGLS 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489738235 241 ASAVVLILVVYGLMVALGNTLGGRWANARPLIALFKMFSGLLITLLILSVTGYSHWLGLLTVLLMGIFAFMNVPGLQLYI 320
Cdd:COG0738 245 EATAALGLSLFWGGMTIGRFLGGFLLKRFGPVRLLRLSALLAAVGLLLALLAPGPWLALIGLALVGLGLSLMFPTIFSLA 324
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*.
gi 489738235 321 VQLAEQNTPhdiTMASALNISAFnVGIALGSGIGGQVTTNLGLGWTPIFGAIMVAV 376
Cdd:COG0738 325 LDGLGKRTA---AAVSAVLIMGI-VGGAIGPPLIGFLADAFGLRAAFLVPLVCYLL 376
|
|
| 2_A_01_02 |
TIGR00880 |
Multidrug resistance protein; |
47-185 |
1.82e-17 |
|
Multidrug resistance protein;
Pssm-ID: 273318 [Multi-domain] Cd Length: 141 Bit Score: 78.46 E-value: 1.82e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489738235 47 GLTVSIYAIGIMIGAPVMTLLTGRLNRHRLMMLIMILFIIGNLLAASAPTFGVLLAGRVVAALAHGIFMTVASVIAADVV 126
Cdd:TIGR00880 1 GLLLAGYALGQLIYSPLSGLLTDRFGRKPVLLVGLFIFVLSTAMFALSSNITVLIIARFLQGFGAAFALVAGAALIADIY 80
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*....
gi 489738235 127 APAKRASAIAIMFTGLTVATVTGVPLGTMIGQLGGWRWSFIFISMIGVIGLLADYWLIP 185
Cdd:TIGR00880 81 PPEERGVALGLMSAGIALGPLLGPPLGGVLAQFLGWRAPFLFLAILALAAFILLAFLLP 139
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
14-376 |
7.97e-17 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 81.32 E-value: 7.97e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489738235 14 LAISAFAIGSTEFISVGLMPLLVSNFHINLAQAGLTVSIYAIGIMIGAPVMTLLTGRLNRHRLMMLIMILFIIGNLLAAS 93
Cdd:cd06174 1 LLLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489738235 94 APTFGVLLAGRVVAALAHGIFMTVASVIAADVVAPAKRASAIAIMFTGLTVATVTGVPLGTMIGQ--LGGWRWSFIFISM 171
Cdd:cd06174 81 APSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASslGFGWRAVFLIAAA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489738235 172 IGVIGLLADYWLIP--------RNLPLPSKATVRGIIRVLTNPQLLFALLVTALGYGGTFVVYTYLSPLLEQQMHWSASA 243
Cdd:cd06174 161 LALLAAILLLLVVPdppesaraKNEEASSKSVLKLLKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLSVAV 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489738235 244 VVLILVVYGLMVALGNTLGGRWAN-ARPLIALFKMFSGLLITLLILSVTGYSHWLGLLTVLLMGIFAFMNVPGLQLYIvq 322
Cdd:cd06174 241 AGLLLSLFGLAGALGSLLLGLLSDrLIGRKPLLLIGLLLMALGLALLLLAPSLLLLLLLLLLLGFGLGGLLPLSFALI-- 318
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....
gi 489738235 323 lAEQNTPHDITMASALNISAFNVGIALGSGIGGqVTTNLGLGWTPIFGAIMVAV 376
Cdd:cd06174 319 -AELFPPEIRGTAFGLLNTFGFLGGAIGPLLAG-FLLAATFGLTGAFLVLAVLL 370
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
7-391 |
1.41e-16 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 80.69 E-value: 1.41e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489738235 7 PSWTLFALAISAFAIGSTEFISVG-LMPLLVSNFHINLAQAGLTVSIYAIGIMIGAPVMTLLTGRLNRHRLMMLIMILFI 85
Cdd:COG2807 15 GRWLLLLAIVLVALNLRPAITSVGpLLPEIRADLGLSATQAGLLTTLPLLAFGLFAPLAPRLARRFGLERTLLLALLLLA 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489738235 86 IGNLLAASAPTFGVLLAGRVVAALAHGI-FMTVASVIAADvvAPAKRASAIAIMFTGLTVATVTGVPLGTMIGQLGGWRW 164
Cdd:COG2807 95 AGLLLRSLAPSVALLLAGTALIGAGIAVgNVLLPGLIKRW--FPDRVGLMTGLYTAAMGLGAALAAGLTVPLAAALGWRG 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489738235 165 SFIFISMIGVIGLLADYWLIPRNLPLPSKATVR-GIIRVLTNPQLLFALLVTALGYGGTFVVYTYLSPLLEQQmHWSASA 243
Cdd:COG2807 173 ALAVWALLALLALLLWLPLLRRRPAAAAAAPAAaSLRSLWRSPLAWLLTLFFGLQSLLYYAVVAWLPPILRDA-GLSAAT 251
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489738235 244 VVLILVVYGLMVALGNTLGGRWANARPLIALFKMFSGLLITLLILSVTGYSHWLGLLTVLLMGIFAFMNVPGLQLYIVQL 323
Cdd:COG2807 252 AGLLLSLFQLAGIPGSLLVPLLADRLGDRRPLLLLLGLLGLAGLLGLLLAPGSLPWLWAVLLGLGQGGLFPLALTLIGLR 331
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 489738235 324 AEqnTPHDITMASALNISAFNVGIALGSGIGGQVTTNLGlGWTPIFgAIMVAVSLVLLLGLIWLARPA 391
Cdd:COG2807 332 AR--TPAEAAALSGMAQSVGYLLAALGPLLVGALHDATG-SWTAAL-LLLAALAVLMLVAGLLAGRPY 395
|
|
| MFS_Tpo1_MDR_like |
cd17323 |
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ... |
20-366 |
6.17e-15 |
|
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340881 [Multi-domain] Cd Length: 376 Bit Score: 75.69 E-value: 6.17e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489738235 20 AIGSTEFISVglMPLLVSNFHINLAQAGLTVSIYAIGIMIGAPVMTLLTGRLNRHRLMMLIMILFIIGNLLAASAPTFGV 99
Cdd:cd17323 12 TFGSSIYSPA--LPQIAEDFHVSEEVANLGVSLFVLGFGLGPLIWAPLSELYGRRPVYLVSLFIFVIFQIGCALAPNIAM 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489738235 100 LLAGRVVAALAHGIFMTVASVIAADVVAPAKRASAIAIMFTGLTVATVTGVPLGTMIGQLGGWRWSFIFISMIGVIGLLA 179
Cdd:cd17323 90 LIILRFLQGFFGSSPLAIGAGTIADLFTPEERGKAMGVYSLGPLLGPALGPIIGGFITQSLGWRWIFWFLAIISGFCLIL 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489738235 180 DywliprnlplpskatvrgiirVLTNPQLLFALLVTALGYGGTFVVYTYLSPLLEQQMHWSASAVVLILVVYGLMVALGN 259
Cdd:cd17323 170 I---------------------FLFLPIVLLLGLYVGLVYAILYLFLTAFPYVFGEVYGFSPGEVGLMYLPIGIGALIGS 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489738235 260 TLGGRW-------------ANARPLIALFKMFSGLL---ITLLILSVTGYSHW---LGLLTVLLMGIFAFMNVPGLQLYI 320
Cdd:cd17323 229 IIGGRLsdyyyrrlkkkngGKPEPEARLPPAFIGAFlfpIGLFIFGWTIYPHIhwiVPIIGSAFFGFGLMLIFQSSLTYL 308
|
330 340 350 360
....*....|....*....|....*....|....*....|....*...
gi 489738235 321 VQLAEQNtphditMASALNISAF--NVGIALGSGIGGQVTTNLGLGWT 366
Cdd:cd17323 309 VDSYPKY------AASALAANTLvrSIFAAIFPLFAQPMFNNLGVGWA 350
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
9-289 |
9.45e-15 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 74.08 E-value: 9.45e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489738235 9 WTLFALAISAFAIGSTEFISVGLMPLLVSNFHINLAQAGLTVSIYAIGIMIGAPVMTLLTGRLNRHRLMMLIMILFIIGN 88
Cdd:COG0477 14 RALLALALGTFLEGLDFTIVNVALPSIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFGLAS 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489738235 89 LLAASAPTFGVLLAGRVVAALAHGIFMTVASVIAADVVAPAKRASAIAIMFTGLTVATVTGVPLGTMIGQLGGWRWSFIF 168
Cdd:COG0477 94 LLCGLAPSPELLIAARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLVAALGWRWIFLI 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489738235 169 ISMIGVIGLLADYWLI-PRNLPLPSKATVRGIIRVLTNPQLLFALLVTALGYGGTFVVYTYLSPLLEQQMHWSASAVVLI 247
Cdd:COG0477 174 NAPLGLLALVLRLRLPeSRGLLLALLALALAALLLAALALALLALLLLLLLLLLALLALLLAGAALLLLLALLLLALLLL 253
|
250 260 270 280
....*....|....*....|....*....|....*....|..
gi 489738235 248 LVVYGLMVALGNTLGGRWANARPLIALFKMFSGLLITLLILS 289
Cdd:COG0477 254 LALLLLAALLLLLLLLLLLALLLALLLLLLLLLLLLLLALLL 295
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
11-376 |
1.76e-14 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 74.18 E-value: 1.76e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489738235 11 LFALAISAFAIGSTEFISVGLMPLLVS--NFHINLAQAGLTVSIYAIGIMIGAPVMTLLTGRLNRHRLMMLIMILFIIGN 88
Cdd:cd17316 1 LLLAGLGWFFDAYDFFLIGFVAPVLAAefSLGLSLLQTGLLFAAGFLGRPIGALLFGYLGDRIGRKKALILTLLLFGLAT 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489738235 89 LLAASAPTFGVLLAGRVVAALAHGIFMTVASVIAADVVAPAKRASAIAIMFT----GLTVATVTGVPLGTMIGQLGGWRW 164
Cdd:cd17316 81 LLIGLLPTPILLLVLRFLQGIGIGGEYPGASTYVAEFAPSKRRGFALGLLQSgwalGALLAALVASLLIPLLSGDWGWRI 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489738235 165 SFIFISMIGVIGLLAdywliprnlplpskatvrgiirvltNPQLLFALLVTALGYGGTFVVYTYLSPLLEQQMHWSASAV 244
Cdd:cd17316 161 LFLIGALPALLALLL-------------------------RRRTLLLILLWFFISFGYYGLTTFLPTYLQTVLGLSPATS 215
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489738235 245 VLILVVYGLMVALGNTLGGRWAN---ARPLIALFKMFSGLLITLLILSVTGYSHWLGLLTVLLMGIFAFMNVpglqLYIV 321
Cdd:cd17316 216 SLYLLLISLGALVGALIAGLLSDrigRKKTLVIGLILSGILALPLFYLLSGSPTLLLLLLFILSFFVGGVWG----ALYA 291
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*
gi 489738235 322 QLAEQNTPHDITMASALNISAFNVGIALGSGIGGQVTTNLGLGWTPIFGAIMVAV 376
Cdd:cd17316 292 YLAELFPTEVRATGVGLSYNLGRLGGGGAPPLIALLLASTGGTGVPALILALLAI 346
|
|
| MFS_Azr1_MDR_like |
cd17502 |
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ... |
31-350 |
2.38e-14 |
|
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341045 [Multi-domain] Cd Length: 337 Bit Score: 73.37 E-value: 2.38e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489738235 31 LMPLLVSNFHiNLAQAGLTVSIYAIGIMIGAPVMTLLTGRLNRHRLMMLIMILFIIGNLLAASAPTFGVLLAGRVVAALA 110
Cdd:cd17502 18 ALPTIVAEFG-GLSLVSWVGTAYLLTSTAFQPIYGKLSDLFGRKWVLLIAIVIFELGSLLCGLAPNMTMLIVGRAIQGIG 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489738235 111 HGIFMTVASVIAADVVAPAKRASAIAIMFTGLTVATVTGVPLGTMIGQLGGWRWSFIFismigviglladywliprNLPL 190
Cdd:cd17502 97 GGGLMSLAFIIIADLVPPRERGKYQGYIGAVFGIASVAGPLIGGAFTDHLSWRWCFYI------------------NLPI 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489738235 191 pskatvrGIIRVLTNPQLLFALLVTALGYGGTFVVYTYLSPLLEQQMHWSASAVVLILVVYGLMVALGNTLGGRWANARP 270
Cdd:cd17502 159 -------GGLALALLRTILLSSIFGFLFGGALFGLIYYLPLYFQLVLGDSATKSGVRLLPLIIGLVIGSIISGALISKTG 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489738235 271 LIALFkMFSGLLITLL--ILSVTGYSHWLGLLTVLLMGIFAFMNVPGLQLYIVQLAEQNTPHDITMASALNISAFNVGIA 348
Cdd:cd17502 232 RYKPL-IVIGTILMSVgaGLLTTLTLDTSKWLLIGYLILLGLGLGIGFQQPLVAVQNAVPPADVGVATATNTFFRSLGGT 310
|
..
gi 489738235 349 LG 350
Cdd:cd17502 311 LG 312
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
31-377 |
2.50e-14 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 73.74 E-value: 2.50e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489738235 31 LMPLLVSNFHINLAQAGLTVSIYAIGIMIGAPVMTLLTGRLNRHRLMMLIMILFIIGNLLAASAPTFGVLLAGRVVAALA 110
Cdd:cd17478 18 LLPLLIAKLGLSYAQAGLLVSVFSITSSLLQPLFGYLADRKPRRYLLPLGPLLTGLGLSLLGFAPNYWLLLLLVALAGIG 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489738235 111 HGIFMTVASVIAAdVVAPAKRASAIAIMFTGLTVATVTGVPLGTMIGQLGGWRWSFIFISMIGVIGLLADYWLIPRNLPL 190
Cdd:cd17478 98 SAAFHPEGARLAS-QAAGGRRGLAMSIFSVGGNLGFALGPLIAAALVALFGGLGLLILLIIPGLAVALLLLRLRPLKKPE 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489738235 191 PSKATVRGIIRVLTNPQLLFALLVTALGYGGTFVVYTYLS--PLLEQQMHWSASAVVLILVVYGLMVALGNTLGGRWANA 268
Cdd:cd17478 177 AKKAAAKSSARSTLKGVWRALLLLLIIVFLRSWVLSSLTTflPFYLVQRGYSLVFAGLLLSLFLFAGAIGTLIGGPLSDR 256
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489738235 269 --RPLIALFKMFSGLLITLLILSVTGyshWLGLLTVLLMGIFAFMNVPglqlYIVQLAEQNTPHDITMASALNISAFNVG 346
Cdd:cd17478 257 fgRRRVIIASLLLAAPFLLLFLLTPG---IWSYILLVLAGFLLFASFP----VTVVLAQELLPGNVGLASGLMMGLSFGL 329
|
330 340 350
....*....|....*....|....*....|.
gi 489738235 347 IALGSGIGGQVTTNLGLGWTPIFGAIMVAVS 377
Cdd:cd17478 330 GGIGAPVLGALADAFGLESVLLILALLPLLG 360
|
|
| MFS_spinster_like |
cd17328 |
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ... |
25-321 |
3.45e-14 |
|
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340886 [Multi-domain] Cd Length: 405 Bit Score: 73.42 E-value: 3.45e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489738235 25 EFISVGLMPLLVSNFHINLAQAGLTVSIYAIGIMIGAPVMTLLTGRLNRHRLMMLIMILFIIGNLLAASAPTFGVLLAGR 104
Cdd:cd17328 15 RFTIAGVLPDIQSDFLIDDSLAGLLQTVFIISYMVLSPIFGYLGDRYNRKWILAVGILIWSAATLLSSFAPNFWQLLLFR 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489738235 105 VVAALAHGIFMTVASVIAADVVAPAKRASAIAIMFTGLTVATVTGVPLGTMIGQL-GGWRWSFIFISMIGVIGLLADYWL 183
Cdd:cd17328 95 ALVGIGEASYSPIAPTIIADLFPKEKRTRALGVFYFAIPLGSGLGYVVGGLVAQAtGGWRWAFRVTGVLGVLLAILLLLF 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489738235 184 IPRNLPLPSKATVRGIIRVLTNPQLLFAL-------LVTALGYGGTFVVY--TYLSPLLEQQMH----WSASAVVLIL-- 248
Cdd:cd17328 175 VREPPRGAAEGGVMAKSTATSFLADLKALaknpsfiLSTLGFTAVSFVTGalAFWAPTFFLRAFgvgdLSSADVGLIFga 254
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489738235 249 --VVYGLM-VALGNTLGGRWA----NARPLIALFKMFSGLLITLLILSVTGYSHWLGLLTVLLMGIFAFMN---VPGLQL 318
Cdd:cd17328 255 itCIAGVLgVLLGGILADRLRrktpRADPLVCAVGLLAAAPFLFLALVLALSNLLLAWVLLFLGEFLLSLNwapVFAILL 334
|
...
gi 489738235 319 YIV 321
Cdd:cd17328 335 YVV 337
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
31-350 |
2.19e-13 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 70.73 E-value: 2.19e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489738235 31 LMPLLVSNFHINLAQAGLTVSIYAIGIMIGAPVMTLLTGRLNRHRLMMLIMILFIIGNLLAASAPTFGVLLAGRVVAALA 110
Cdd:cd17475 18 LAPFLQEDLHLSLAQVGLLLSALNLGVAVSMLPAGWLLDRFGERRVLAVGLLLMGAAALLMALVGSYPVLLVLLFLVGAG 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489738235 111 HGIFMTVASVIAADVVAPAKRASAIAIMFTGLTVATVTGVPLGTMIGQLGGWRWSFIFISMIGVIGLLAdYWLIPRNLPL 190
Cdd:cd17475 98 YGSVQPGGGRAIMRWFPPRERGLAMGIRQTGVPLGGALAAALLPPLALHYGWRAAFVVAGLVSILAAVL-FWLFYREPPA 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489738235 191 PSKAT------VRGIIRVLTNPQLLFALLVTALGYGGTFVVYTYLSPLLEQQMHWSASAVVLILVVYGLMVALGNTLGGR 264
Cdd:cd17475 177 ASAATesastlLRSLKEVLRNRDVWLIAIAGALLVAPQFALLTFLLLFLHDHLGLSVVAAGALLAVAQLGGALGRIGLGR 256
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489738235 265 WA------NARPLIALFKMFSGLLITLLILSVTGYSHWLGLLTVLLMGIFAFMNVPglqLYIVQLAEQNTPHDITMASAL 338
Cdd:cd17475 257 VSdrvfggRRRPVLVITAAIAAAALLVLSLLSPGTPLWLLVLLLILLGLFAIGWNG---LYLTLVAESAGPEQAGTALGL 333
|
330
....*....|..
gi 489738235 339 NISAFNVGIALG 350
Cdd:cd17475 334 ANTINFIGIAIG 345
|
|
| MFS_FucP_MFSD4_like |
cd17333 |
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ... |
14-376 |
7.03e-13 |
|
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340891 [Multi-domain] Cd Length: 372 Bit Score: 69.27 E-value: 7.03e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489738235 14 LAISAFAIGSTEFISVGLMPLLVSNFHINLAQAGLTVSIYAIGIMIGAPVMTLLTGRLNRHRLMMLIMILFIIGNLLAAS 93
Cdd:cd17333 1 LYISFFSNGLTDALLGILGPSLEEAFNLNVADVSVIFSSQNAGYLIGSLLAGFLMKRLGRRRTLILGLLLISLALALIFA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489738235 94 APTFGVLLAGRVVAALAHGIFMTVASVIAADVVaPAKRASAIAIMFTGLTVATVTGVPLGT-MIGQLGGWRWSFIFISMI 172
Cdd:cd17333 81 TPSIYLFVVLMFLAGLGAGILDTGANTFVGALF-EESSATRLNVLHGFFGLGALIGPLIATsLLTSELSWSWAYLIIGLI 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489738235 173 GVIGLLAdyWLIPRNLPLPS--------KATVRGIIRVLTNPQLLFALLVTALGYGGTFVVYTYLSPLLEQQMHWSASAV 244
Cdd:cd17333 160 YLLLAIL--ILLTLFPELPSarnpqqsvGAFSASASRLLRNPSIILGALALFLYVGAETAFSSWVPSYLVEKKHVSDGLA 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489738235 245 VLILVVYGLMVALGNTLGGRWANA-RPLIALFKMFSGLLITLLILSVTGYSHWLGLLTVLLmGIFAFMNVPGlqlyIVQL 323
Cdd:cd17333 238 GYLLSGFWVGITIGRLLGGPISRRiKPHTLLVLSGSGALLGLLILLLAPTLVVGLVATALL-GLFMAALFPT----ILSL 312
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|...
gi 489738235 324 AEQNTPHDITMASALNISAFNVGIALGSGIGGQVTTNLGLGWTPIFGAIMVAV 376
Cdd:cd17333 313 GISNLPYAKGKGTSVLLAAGSIGGAIIPFIMGFIAEAVGIQTAMLLITILYAI 365
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
14-349 |
1.66e-12 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 68.37 E-value: 1.66e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489738235 14 LAISAFAIGSTEFISVGLMPLLVSNFHINLAQAGLTVSIYAIGIMIGAPVMTLLTGRLNRHRLMMLIMILFIIGNLLAAS 93
Cdd:cd17473 5 LLASTLTVMAGAAIAPALPAIAQHFVPNSELLVPLLLTLPALFIALFAPLAGWLADRFGRKRLLIAGLLLYGIGGVAGLF 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489738235 94 APTFGVLLAGRVVAALAHGIFMTVASVIAADVVAPAKRASAIAIMFTGLTVATVTGVPLGTMIGQLgGWRWSFIFISMIG 173
Cdd:cd17473 85 LDSLYALLASRALLGIGVAGIMTLATALIGDYFEGEERAKMLGLQSAAMSLGGVVFLLLGGALAEI-GWRAPFLVYLLAL 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489738235 174 VIGLLADYWL-IPRNLPLPSKATVRGIIRVLTNPQLLFALLVTALGYGGTFVVYTYLSPLLEQQMHWSASAVVLILVVYG 252
Cdd:cd17473 164 PVLILVLLFLpEPARKSKSAASPGAATAAALPWKRVLPIYFLAFLAMLLFYVIPIQLPFLLQERGGGSAALIGLALAIAS 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489738235 253 LMVALGNTLGGRWANARPLIALFKMFSGLLITLLILSVTGYSHWLGLLTVLLMGIFAFMNVPGLQLYIVQLAeqnTPHDI 332
Cdd:cd17473 244 LAGAIGALLFGRLKRRLGKRRLLAIGFALMALGFLLLALASGLWVVLLGAILAGLGFGLLLPTLNSWAMSLV---PPELR 320
|
330
....*....|....*..
gi 489738235 333 TMASALNISAFNVGIAL 349
Cdd:cd17473 321 GRAMGIVTSAFFLGQFL 337
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
7-355 |
3.07e-12 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 67.62 E-value: 3.07e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489738235 7 PSWTLFALAISAFAIG-STEFISVGLMPLLVSNFHINLAQAGLTVSIYAIGIMIGAPVMTLLTGRLN-----RHRLMMLI 80
Cdd:COG2211 8 SLKEKLAYGLGDLGLNlAFGLLSAYLLYFYTDVLGLSAALVGLILLVARLWDAITDPLIGALSDRTRtrwgrRRPWILIG 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489738235 81 MILFIIGNLLAASAPTFG------VLLAGRVVAALAHGIFMTVASVIAADVVA-PAKRASAIAIMFTGLTVATVTGVPLG 153
Cdd:COG2211 88 AIPLALSFVLLFTAPDLSptgkliYALVTYLLLGLAYTLVNIPYSALGAELTPdYEERTRLSSWRFAFAGLGGLLASVLP 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489738235 154 TMI------GQLGGWRWSFIFISMIGVIGLLADYWLIP-RNLPLPSKATVRGIIR-VLTNPQLLFALLVTALGYGGTFVV 225
Cdd:COG2211 168 PPLvaafggDAALGYRLTALIFAVLGLLAFLLTFFGTKeRPVPEEEKVSLKESLKaLLKNRPFLLLLLAYLLFFLALALV 247
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489738235 226 YTYLSPLLEQQMHWSASAVVLILVVYGLMVALGNTLGGRWANA--RPLIALFKMFSGLLITLLILSVTGYSHWLGLLTVL 303
Cdd:COG2211 248 AALLLYYFKYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKRfgKKKAFIIGLLLAALGLLLLFFLGPGNLWLLLVLAA 327
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|..
gi 489738235 304 LMGIFAFMNVPGLQLYIVQLAEQNTPHDITMASALNISAFNVGIALGSGIGG 355
Cdd:COG2211 328 LAGIGLGAILVLPWAMLADVVDYDEWKTGRRREGLYFGIFTFAIKLGQALAG 379
|
|
| MFS_PcaK_like |
cd17365 |
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ... |
33-310 |
7.21e-12 |
|
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340923 [Multi-domain] Cd Length: 351 Bit Score: 66.07 E-value: 7.21e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489738235 33 PLLVSNFHINLAQAGLTVSIYAIGIMIGAPVMTLLTGRLNRHRLMMLIMILFIIGNLLAASAPTFGVLLAGRVVAALAHG 112
Cdd:cd17365 23 PALAQDWGLSPAQLGPVGSAALFGMAIGALLAGPLADRFGRKRVLLVSVALFGLFTLLTAFAQSVLQLALLRFLTGLGLG 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489738235 113 IFMTVASVIAADVVAPAKRASAIAIMFTGLTVATVTGVPLGTMIGQLGGWRWSFifisMIGVIGLLadywliprnlplps 192
Cdd:cd17365 103 AAMPNAITLVSEYAPARRRSLAVTLMFCGYPLGAALGGFLAAALIPAFGWRSVF----LLGGVPPL-------------- 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489738235 193 katvrgIIRVLTNPQLLFAlLVTALGYGGTFVVYTYLsPLLEQQMHWSASAVVLILVVYGLMVALGNTLGGRWA---NAR 269
Cdd:cd17365 165 ------ILLPLLRGTLLLW-VTFFMGLLLVYLLNSWL-PKLMVEAGYSLSQALTITLLLNIGGVIGSLLLGWLAdrfGPK 236
|
250 260 270 280
....*....|....*....|....*....|....*....|.
gi 489738235 270 PLIALFKMFSGllITLLILSVTGYSHWLGLLTVLLMGIFAF 310
Cdd:cd17365 237 RVLALFFALGA--VSLALLGVSPASLVLLYVLVFLAGACVN 275
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
11-376 |
1.37e-11 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 65.27 E-value: 1.37e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489738235 11 LFALAISAFAIGstefISVGLMPLLVSNFHINLAQAGLTVSIYAIGIMIGAPVMTLLTGRLNRHRLMMLIMILFIIGNLL 90
Cdd:cd17477 2 LLSVALLGLGSG----LLLPLLSLRLEREGVSTALIGLVASAYYLGILLGSPLVPRLIRRVGHIRAFAAGAAITAVSVLL 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489738235 91 AASAPTFGVLLAGRVVAALAHGIFMTVASVIAADVVAPAKRASAIAIMFTGLTVATVTGvPLGTMIGQLGGWRWsFIFIS 170
Cdd:cd17477 78 LALTDSPWVWFLLRFVMGIGLAGLFVVSESWLNALATNENRGRVLGLYSTVLGLGFALG-PLLLALVGTAGALP-FLIAA 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489738235 171 MIGVIGLLAdYWLIPRNLPLPSKATVRGIIRVLtnpQLLFALLVTALGYGGTFVVYTYLSPLLEQQMHWSASAVVLILVV 250
Cdd:cd17477 156 VLLLLALVP-LLLTRRAAPEIEEAESISLRRLL---RIAPLALLGAFVAGFLEGAFYSLLPLYGLRLGLSVAQAALLLAA 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489738235 251 YGLMVALGNTLGGRWAN--ARPLIALFKMFSGLLITLLILSVTGYSHWLGLLTVLLMGIFAFMNVpglqLYIVQLAEQNT 328
Cdd:cd17477 232 FVLGGLLLQWPLGWLADrfDRRRVLLGCALLGALAALLLPLVPGLPLALLVLLFLWGGAAGPLYT----LALALAGDRLP 307
|
330 340 350 360
....*....|....*....|....*....|....*....|....*...
gi 489738235 329 PHDITMASALNISAFNVGIALGSGIGGQVTTNLGLGWTPIFGAIMVAV 376
Cdd:cd17477 308 GDELVAANAALLLLYGLGSVIGPLLAGALMDAFGPHGLFLFLAAVALL 355
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
45-377 |
2.65e-11 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 64.52 E-value: 2.65e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489738235 45 QAGLTVSIYAIGIMIGAPVMTLLTGRLNRHRLMMLIMILFIIGNLLAASAPTFGVLLAGRVVAALAHGIFmTVASVIAAD 124
Cdd:cd17330 35 YVGLLQSSYSLGQFLASPLWGRLSDRYGRKPVLLLSLAGSAVSYVLLGLSRNLWLLFLARFLDGLTGGNV-SVAQAYIAD 113
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489738235 125 VVAPAKRASAIAIMFTGLTVATVTGVPLGTMIGQLGGWRWSFIFISMIGVIGLLADYWLIPRnlplpskatvrgiirvlt 204
Cdd:cd17330 114 ITDEEERAKAFGIISAAFGLGFILGPALGGFLSTPYGYALPFLVAAALALLNLVLVLFFLPP------------------ 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489738235 205 npqLLFALLVTALGYGGTFVVYTYLSPLLEQQMHWSASAVVLILVVYGLMVALGNTLGGRWANAR-PLIALfkMFSGLLI 283
Cdd:cd17330 176 ---LRRLLLVYFLIALAFAGLESVFSLFLKDRFGFSPSQIGLLLALVGIAGILAQLLLIPRLAKRlGERKL--LRLGLLL 250
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489738235 284 TLLILSVTGYShWLGLLTVLLMGIFAFMNVPGLQLYIVQLAEQNTPHDITMASALNISAFNVGIALGSGIGGQVTTNLGL 363
Cdd:cd17330 251 AIIGLLLLPFA-SSVPLLVLAAAILAFGTGIVFPALSALLSKSVPSKEQGKAQGIIQSLQSLARIIGPLLAGPLYSFLGP 329
|
330
....*....|....
gi 489738235 364 GWTPIFGAIMVAVS 377
Cdd:cd17330 330 GVPFLLAAGLLLIA 343
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
31-311 |
3.12e-11 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 64.13 E-value: 3.12e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489738235 31 LMPLLVSNFHINLAQAGLTVSIYAIGIMIGAPVMTLLTGRLNRHRLMMLIMILFIIGNLLAASAPTFGVLLAGRVVAALA 110
Cdd:cd17319 25 AAPTIMKDLGLSPTQYGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSLFTALTGFATSLTSLYVLRFLLGVA 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489738235 111 HGIFMTVASVIAADVVAPAKRASAIAIMFTGLTVATVTGVPLGTMIGQLGGWRWSFIFISMIGVIGLLADYWLIPRnlpl 190
Cdd:cd17319 105 EAGFFPGAIKALAEWFPARERGRATGLFNSGAPLGAAIGPPLSGWLLLLFGWRWAFIIEGLLGLLLAVLWWFYLRQ---- 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489738235 191 pskatvrgiirvltnpqlLFALLVTALGYGGTFVVY-TYLSPLLEQQMHWSASAVVLILVVYGLMVALGNTLGGRWA--- 266
Cdd:cd17319 181 ------------------VWGLALGYFGINYALYGLlTWLPTYLKQARGFSLKQVGLLAAIPFLAGAIGMILGGRLSdrl 242
|
250 260 270 280
....*....|....*....|....*....|....*....|....*..
gi 489738235 267 --NARPLIALFKMFSGLLITLLILSVTGYSHWLGLLTVLLMGIFAFM 311
Cdd:cd17319 243 lrGARRLVIIIGLLLAAVGLLLAYLTTSPVVAVILLSLAGFGIGAAS 289
|
|
| MFS_YxlH_like |
cd17490 |
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ... |
26-303 |
1.62e-10 |
|
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341043 [Multi-domain] Cd Length: 371 Bit Score: 62.24 E-value: 1.62e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489738235 26 FISVGLMPLLVSNFHINLAQAGLTVSIYAIGIMIGAPVMTLLTGRLNRHRLMMLIMILF-IIGNLLAASAPTFGVLLAGR 104
Cdd:cd17490 13 YVYVPFLSPYAESLGASLSMIGIILGAYGISQMLLRIPLGILSDRIGKRKLFIIIGLLFtVLASLIMILFPSPWGLLIAR 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489738235 105 VVAALAhGIFMTVASVIAADVVAPAKRASAIAIMFTGLTVATVTGVPLGTMIGQLGGWRWSFIFISMIGVIGLLADYWLI 184
Cdd:cd17490 93 FLSGIA-AATWVSFTVLYASYFPPDEAAKAMGLINLVNNLGQLIAFLIGGLIAEHFGMRAPFLLAALAGVLGFILSLFIK 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489738235 185 -PRNLPLPSKATVRGIIRVLTNPQLLFALLVTALGYGGTFVVYTYLSPLLEQQMHWSASAVVLILVVYGLMVALGNTLGG 263
Cdd:cd17490 172 eERREKKPVLTELKELLSVLKDKKLLFFSLLAILQQMITFSTTFGFTPLIAKQLGASSFQLGLLSIIYLLPNALASLLSG 251
|
250 260 270 280
....*....|....*....|....*....|....*....|
gi 489738235 264 rWANARPLIALFKMFSGLLITLLILSVTGYSHWLGLLTVL 303
Cdd:cd17490 252 -TLFYKKLGERNTIIIGFLLLGAYCFLIPFAPNLTLLYLL 290
|
|
| MFS_TetA |
cd17388 |
Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily ... |
31-269 |
2.18e-10 |
|
Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of tetracycline resistance proteins similar to Escherichia coli TetA(A), TetA(B), and TetA(E), which are metal-tetracycline/H(+) antiporters that confer resistance to tetracycline by an active tetracycline efflux, which is an energy-dependent process that decreases the accumulation of the antibiotic in cells. TetA-like tetracycline resistance proteins belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340946 [Multi-domain] Cd Length: 385 Bit Score: 61.88 E-value: 2.18e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489738235 31 LMPLLVSNFHINLAQA----GLTVSIYAIGIMIGAPVMTLLTGRLNRHRLMMLIMILFIIGNLLAASAPTFGVLLAGRVV 106
Cdd:cd17388 21 VLPTLLREFVGDSADAathyGVLLALYALMQFIFAPILGALSDRFGRRPVLLLSLAGAALDYLLMAFAPTLWWLYLGRII 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489738235 107 AALAhGIFMTVASVIAADVVAPAKRASAIAIMFTGLTVATVTGVPLGTMIGQLGGwRWSFIFISMIGVIGLLADYWLIPR 186
Cdd:cd17388 101 AGIT-GATGAVAAAYIADVTPPEQRARNFGLLGAAFGLGFIAGPALGGLLGEISP-RAPFLVAAGLNGLNFLLGLFVLPE 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489738235 187 NLP-------LPSKATVRGIIRVLTN-PQLLFALLVTALGYGGTFVVYTYLSPLLEQQMHWSASAVVLILVVYGLMVALG 258
Cdd:cd17388 179 SLPperrrafRWRRANPFGSLRWLTGfPGLLGLLAVFFLIQLIGQVPATTWVLFTEDRFDWSPTMVGLSLAVFGLLHALF 258
|
250
....*....|.
gi 489738235 259 NTLGGRWANAR 269
Cdd:cd17388 259 QAFVTGPIAKR 269
|
|
| MFS_MucK |
cd17371 |
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ... |
12-311 |
3.46e-10 |
|
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340929 [Multi-domain] Cd Length: 389 Bit Score: 61.16 E-value: 3.46e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489738235 12 FALAISAFAIGSTEFISVGLM-PLLVSNFHINLAQAGLTVSIYAIGIMIGAPVMTLLTGRLNRHRLMMLIMILFIIGNLL 90
Cdd:cd17371 1 FWAAFLGWALDGFDLLLLGLVlPALIAEFGLDEAEAGLLGTVTLAGGAIGGILGGILADRFGRVRVLVITILLFAVFTLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489738235 91 AASAPTFGVLLAGRVVAALAHGIFMTVASVIAADVVAPAKRASAIAIMFTGLTVATVTGVPLGTMIGQLG----GWRWSF 166
Cdd:cd17371 81 CGFAQNYWQLLILRALAGLGFGGEWAAGAALMAEYVPARHRGKALGYVQSGWAVGWLLATLLAALLFPLLppeiAWRVLF 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489738235 167 IFismiGVIGLLAdYWLIPRNLPLPSKATV----------RGIIRVLTNPQLLFALLVTAL----GYGGTFVVYTYLSPL 232
Cdd:cd17371 161 LL----GALPALL-VLFIRRFVKEPPQWQAaraarrhfadRPSLRELFSPPLLRTTLLASLlatgALGGYYGITTWLPSY 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489738235 233 LEQQMHWSASAVVLILVVYGLMVALGNTLGGRWANA---RPLIALFKMFSGLLITLLILSVTGYSHWLGLLTVLLM---G 306
Cdd:cd17371 236 LTGERGLSFEGSAGYLVVTILGGFLGYLAGGFLADRigrRNNFALFALGSAISILLYFFLPLSPTLILILGFPLGFfasG 315
|
....*
gi 489738235 307 IFAFM 311
Cdd:cd17371 316 PFSGM 320
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
11-376 |
7.33e-10 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 59.93 E-value: 7.33e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489738235 11 LFALAISAFAIGSTEFISVGLMPL-LVSNFHINLAQAGLTVSIYAIGIMIGAPVMTLLTGRLNRHRLMMLIMILFIIGNL 89
Cdd:cd17329 1 LWVLLIGSFLNRLGFFMVWPFMAIyLHQQLGLSASIVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489738235 90 LAASAPTFGVLLAGRVVAALAHGIFMTVASVIAADVVAPAKRASAIAIMFTGLTVATVTGVPLGTMIGQLGGwRWSFIFI 169
Cdd:cd17329 81 LLGFAHSPWLFAIALVLTGFGGGLFEPASEAMIADVTTPENRTRAFSLLYWAINLGVAIGPLLGGLLLLYSF-RLLFLAA 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489738235 170 SMIGVIGLLADYWLIPRNLPLPSKATVRGIIR----VLTNPQLLFALLVTALGYGGTFVVYTYLSPLLEQQMHWSASAVV 245
Cdd:cd17329 160 AVLFLLAALVLLFLLPETRPKRRAAEKTEILRgykiVLRDRAFLLFLLASFLISLIYFQLESTLPVYVVEILGLGESLLG 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489738235 246 LILVVYGLMVALGNTLGGRWANARPLIALFKMFSGLLITLLILSVTGYSHWLGLLTVLLMGIFAFMNVPGLQLYIVQLAE 325
Cdd:cd17329 240 LLLALNALLIVLLQFPVARLVERFRLRKILMIGILLFAIGFAVLAFANTLAVLILAMIVLTLGEMLVFPAVQTLVAALAP 319
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|..
gi 489738235 326 qntPHDITMASALNISAFNVGIALGSGIGGQVTTNLGLGWT-PIFGAIMVAV 376
Cdd:cd17329 320 ---PDKRGSYMGFYALAWGLGRAIGPLVGGLLLDLLGPGLPwLILAALGLIA 368
|
|
| efflux_EmrB |
TIGR00711 |
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a ... |
32-193 |
1.01e-09 |
|
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other]
Pssm-ID: 129794 [Multi-domain] Cd Length: 485 Bit Score: 60.09 E-value: 1.01e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489738235 32 MPLLVSNFHINLAQAGLTVSIYAIGIMIGAPVMTLLTGRLNRHRLMMLIMILFIIGNLLAASAPTFGVLLAGRVVAALAH 111
Cdd:TIGR00711 25 IPTIAGDLGSSLSQVQWVITSYMLANAISIPLTGWLAKRFGTRRLFLISTFAFTLGSLLCGVAPNLELMIIFRVIQGFGG 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489738235 112 GIFMTVASVIAADVVAPAKRASAIAIMFTGLTVATVTGVPLGTMIGQLGGWRWSFIFISMIGVIGLLADYWLIPRNLPLP 191
Cdd:TIGR00711 105 GPLIPLSFSTLLNIYPPEKRGRAMAIWGLTVLVAPALGPTLGGWIIENYHWRWIFLINVPIGIIVVVVAFFILPRDKPAA 184
|
..
gi 489738235 192 SK 193
Cdd:TIGR00711 185 SE 186
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
44-377 |
1.07e-09 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 59.55 E-value: 1.07e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489738235 44 AQAGLTVSIYAIGIMIGAPVMTLLTGRLNRHRLMMLIMIL-----FIIGNLLAASAPTFGVLLAGRVVAALAHGIFMTVA 118
Cdd:cd06173 34 LLVGLVLAAFFLPFLLFSPFAGVLADRFDRRRLLILADLLrallaAVLALLALLGSLSLWLLLVLAFLLGIASAFFGPAR 113
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489738235 119 SVIAADVVAPAKRASAIAIMFTGLTVATVTGVPLGTMIGQLGGWRWSFIFISMIGVIGLLAdYWLIPRNLPLPSK----- 193
Cdd:cd06173 114 QALLPELVPKEQLVRANALNSLATQLARIIGPALGGLLVALLGPGGAFAINALSFLLSALL-LLFIRRPPPAAPGesssl 192
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489738235 194 ---ATVRGIIRVLTNPQLLFALLVTALGYGGTFVVYTYLSPLLEQQMHWSASAVVLILVVYGLMVALGNTLGGRWANARP 270
Cdd:cd06173 193 llrDLREGLRYLRRSPLLRLLLLALALFALLGGALTVLLPLLAKEVLGGGAAGYGLLLAAFGVGALLGALLLGRLSKRRR 272
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489738235 271 LIALFKMFSGLLITLLILSVTGYSHWLGLLTVLLMGIFAFMNVPGLQLYIVQLAEqntPHDITMASALNISAFNVGIALG 350
Cdd:cd06173 273 RGRLLLIGALLLGLALLVLGLSPSLWLLLAALFLLGLAGGLFNVPLNTLLQLRVP---DELRGRVFSVYNALNSGAMPLG 349
|
330 340
....*....|....*....|....*..
gi 489738235 351 SGIGGQVTTNLGLGWTPIFGAIMVAVS 377
Cdd:cd06173 350 ALLAGLLADALGLSAVFLLAGALLLLA 376
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
11-184 |
1.11e-09 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 59.51 E-value: 1.11e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489738235 11 LFALAISAFAIGSTEFISVgLMPLLVSNFHINLAQAGLTVSIYAIGIMIGAPVMTLLTGRLNRHRLMMLIMILFIIGNLL 90
Cdd:cd17325 203 ALFLAIFVLAFAFGALEPF-LPLYAAELGGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVALLL 281
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489738235 91 AASAPTFGVLLAGRVVAALAHGIFMTVASVIAADVVAPAKRASAIAIMFTGLTVATVTGVPLGTMIGQLGGWRWSFIFIS 170
Cdd:cd17325 282 LPLATSFWLLLLLLALLGLGLGLVFPATLALLADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAFGFATPFLAAA 361
|
170
....*....|....
gi 489738235 171 MIGVIGLLADYWLI 184
Cdd:cd17325 362 ALLLLAAVLFLLLR 375
|
|
| MFS_YjiJ |
cd06180 |
Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of ... |
11-355 |
2.64e-09 |
|
Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Escherichia coli YjiJ and other uncharacterized proteins. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340869 [Multi-domain] Cd Length: 371 Bit Score: 58.47 E-value: 2.64e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489738235 11 LFALAISAFAIGSTEFISVGLMPLLVSNFHINLAQAGLTVSIYAIGIMIGAPVMTLLTGRLNRHRLMMLIMILFIIGNLL 90
Cdd:cd06180 1 LAGALALAVAMGIGRFAYTPLLPLMLAELGLSYAQAGWIATANYAGYLVGALLASFLRRRGRARRLIRGGLLLTVLLLAA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489738235 91 AASAPTFGVLLAGRVVAALAHGIFMTVASVIAADVVAPAKRASAIAIMFTGLTVAT-VTGVPLGTMIGQLGGWRWSFIFI 169
Cdd:cd06180 81 MALTSGFAALLALRFLAGAASAFVFVFGSNLVLHHATAAGRGHLIGLLFAGVGLGIaLSGLLVPAGLGGGLSWRAGWLAL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489738235 170 SMIGVIGLLADYWLIPRNLPLPSKATVRGiiRVLTNPQLLFALLVTALGYGGTFVVYTYLSPLLEQQMHWSASAVVLILV 249
Cdd:cd06180 161 ALLSAVLLLLSFLLLRRGPSAPTEASAAE--SAPGLNRPLWRLALAYGLFGFGYIITATFLPLIARETGAGSLLAGLLWS 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489738235 250 VYGLMVALGNTLGGRWANARPLIALFKMFSGLLITLLILSVTGYSHWLGLLTVLLMGiFAFMNVPGLqlyIVQLAEQNTP 329
Cdd:cd06180 239 LFGLAAVPSCFLWGALSDRWGTRRALAANLLVQAVGVLLPLLSPGPAGLVLSAVLFG-GTFMAITAL---VMALARELAP 314
|
330 340
....*....|....*....|....*.
gi 489738235 330 HDITMASALNISAFNVGIALGSGIGG 355
Cdd:cd06180 315 PAAPRALALMTASFGVGQILGPLLAG 340
|
|
| MFS_GLUT6_8_Class3_like |
cd17358 |
Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major ... |
12-175 |
3.51e-09 |
|
Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of glucose transporter type 6 (GLUT6), GLUT8, plant early dehydration-induced gene ERD6-like proteins, and similar insect proteins including facilitated trehalose transporter Tret1-1. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). Insect Tret1-1 is a low-capacity facilitative transporter for trehalose that mediates the transport of trehalose synthesized in the fat body and the incorporation of trehalose into other tissues that require a carbon source. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340916 [Multi-domain] Cd Length: 436 Bit Score: 58.36 E-value: 3.51e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489738235 12 FALAISAFAIGSTEFISVGLMPLLVS----NFHINLAQAGLTVSIYAIGIMIGAPVMTLLTGRLNRHRLMMLIMILFIIG 87
Cdd:cd17358 5 FVANLGSFSFGIAVGWSSPALPSLMSdnslSLPLTVAQFSWFGSLLTLGALIGALLSGKLADRIGRKRTLLISAIPCILG 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489738235 88 NLLAASAPTFGVLLAGRVVAALAHGIFMTVASVIAADVVAPAKRASAIAIMftglTVATVTGVPLGTMIGQLGGWRWSFI 167
Cdd:cd17358 85 WLLIAFAKDVWMLYLGRFLAGFGGGAASVVVPVYIAEIAPKNVRGALGSLN----QLLVNIGILLGYVLGSFLPWRTLAL 160
|
....*...
gi 489738235 168 FISMIGVI 175
Cdd:cd17358 161 IGAIPPVV 168
|
|
| Sugar_tr |
pfam00083 |
Sugar (and other) transporter; |
45-183 |
5.89e-09 |
|
Sugar (and other) transporter;
Pssm-ID: 395036 [Multi-domain] Cd Length: 452 Bit Score: 57.67 E-value: 5.89e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489738235 45 QAGLTVSIYAIGIMIGAPVMTLLTGRLNRHRLMMLIMILFIIGNLLAASAP---TFGVLLAGRVVAALAHGIFMTVASVI 121
Cdd:pfam00083 47 LSGLIVSIFSVGCFIGSLFAGKLGDRFGRKKSLLIANVLFVIGAVLQGAAKgkwSVYQLIVGRVLVGIGVGGASVLAPMY 126
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 489738235 122 AADvVAPAKRASAIAIMFtglTVATVTGVPLGTMIGQL-------GGWRWSFIFISMIGVIGLLADYWL 183
Cdd:pfam00083 127 ISE-IAPKKLRGALGSLY---QLAITFGILLAYIFGLGlnktsnsDGWRIPLGLQLVPALLLIIGLLFL 191
|
|
| MFS_GLUT_like |
cd17315 |
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator ... |
38-183 |
6.75e-09 |
|
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator Superfamily; This family is composed of glucose transporters (GLUTs) and other sugar transporters including fungal hexose transporters (HXT), bacterial xylose transporter (XylE), plant sugar transport proteins (STP) and polyol transporters (PLT), H(+)-myo-inositol cotransporter (HMIT), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. The GLUT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340873 [Multi-domain] Cd Length: 365 Bit Score: 57.20 E-value: 6.75e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489738235 38 NFHINLAQAGLTVSIYAIGIMIGAPVMTLLTGRLNRHRLMMLIMILFIIGNLLAASAPTFGVLLAGRVVAALAHGIFMTV 117
Cdd:cd17315 28 GFGLSTSLQGLVVSSLLLGAAIGSLFGGPLADRFGRRKSLLIAAVLYVIGALLSALAPNVWVLIVGRFLLGLGVGLASVL 107
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 489738235 118 ASVIAADvVAPAKRASAIAIMF-----TGLTVATVTGVPLGTMIGqlGGWRWSFIFISMIGVIGLLADYWL 183
Cdd:cd17315 108 VPLYISE-IAPAKIRGALGTLNqlmitFGILLAYLLGLALSLSPP--GWWRLMFALAAVPALLQLLLMFFL 175
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
9-316 |
6.77e-09 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 57.37 E-value: 6.77e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489738235 9 WTLFALAISAFAIGSTEFISVGLM-PLLVSNFHINLAQAGLTVSIYAIGIMIGAPVMTLLTGRLNRHRLMMLIMILFIIG 87
Cdd:TIGR00895 16 WRAIILSFLIMLMDGYDLAAMGFAaPAISAEWGLDPVQLGFLFSAGLIGMAFGALFFGPLADRIGRRRVLLWSILLFSVF 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489738235 88 NLLAASAPTFGVLLAGRVVAALAHGIFMTVASVIAADVVAPAKRASAIAIMFTGLTVATVTGVPLGTMIGQLGGWRWSFI 167
Cdd:TIGR00895 96 TLLCALATNVTQLLILRFLAGLGLGGLMPNLNALVSEYAPKRFRGTAVGLMFCGYPIGAAVGGFLAGWLIPVFGWRSLFY 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489738235 168 FISMIGVIGLladyWLIPRNLPLPSKATV------------------------------------RGIIRVLTNPQLLFA 211
Cdd:TIGR00895 176 VGGIAPLLLL----LLLMRFLPESIDFLVskrpetvrrivnaiapqmqaeaqsalpeqkstqgtkRSVFKALFQGKTARI 251
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489738235 212 LLVTALGYGGTFVVYTYLS---PLLEQQMHWSASAVVLILVVYGLMVALGNTLGGRWAN--ARPLIALFKMFSGLLITLL 286
Cdd:TIGR00895 252 TVLLWLLYFMLLVGVYFLTnwlPKLMVELGFSLSLAATGGALFNFGGVIGSIIFGWLADrlGPRVTALLLLLGAVFAVLV 331
|
330 340 350
....*....|....*....|....*....|
gi 489738235 287 ILSVTGYShwLGLLTVLLMGIFAFMNVPGL 316
Cdd:TIGR00895 332 GSTLFSPT--LLLLLGAIAGFFVNGGQSGL 359
|
|
| MFS_XylE_like |
cd17359 |
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This ... |
30-185 |
1.34e-08 |
|
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This subfamily includes bacterial transporters such as D-xylose-proton symporter (XylE or XylT), arabinose-proton symporter (AraE), galactose-proton symporter (GalP), major myo-inositol transporter IolT, glucose transport protein, putative metabolite transport proteins YfiG, YncC, and YwtG, and similar proteins. The symporters XylE, AraE, and GalP facilitate the uptake of D-xylose, arabinose, and galactose, respectively, across the boundary membrane with the concomitant transport of protons into the cell. IolT is involved in polyol metabolism and myo-inositol degradation into acetyl-CoA. The XylE-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340917 [Multi-domain] Cd Length: 383 Bit Score: 56.04 E-value: 1.34e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489738235 30 GLMPLLVSNFHINLAQAGLTVSIYAIGIMIGAPVMTLLTGRLNRHRLMMLIMILFIIGNLLAASAPTFGVLLAGRVVAAL 109
Cdd:cd17359 22 GALPFLQTDFNLTPFLEGLVVSSALLGAAIGALFAGRLADRFGRRKTLLISAVLFFISALGSAFSPNFTIFIIARIIGGL 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489738235 110 AHGIFMTVASVIAADVVAPAKRASA-----IAIMFTGLTVATVT---GVPLGTMIGQLGGWRWSFiFISMIGVIGLLADY 181
Cdd:cd17359 102 AVGGASALVPMYIAEVAPAEIRGRLvslnqLMIVFGQLLAYIVNyliANAGGADWLGAEGWRWML-GLEAIPAILFLLGM 180
|
....
gi 489738235 182 WLIP 185
Cdd:cd17359 181 LFIP 184
|
|
| MFS_SLC22 |
cd17317 |
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major ... |
45-188 |
1.49e-08 |
|
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily; The Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. The SLC22 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340875 [Multi-domain] Cd Length: 331 Bit Score: 55.66 E-value: 1.49e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489738235 45 QAGLTVSIYAIGIMIGAPVMTLLTGRLNRHRLMMLIMILFIIGNLLAASAPTFGVLLAGRVVAALAHGIFMTVASVIAAD 124
Cdd:cd17317 26 LVALVQTIFFLGVLIGSLLFGYLADRFGRRPVLLLGLVLQIVCGVLSAFSPSYELFLVLRFLVGVTSAGIFTVGFVLGME 105
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 489738235 125 VVAPAKRASAIAIMFTGLTVATVTGVPLGTMIGQlggWRWSFIFISMIGVIgLLADYWLIPRNL 188
Cdd:cd17317 106 IVGPKYRSFVGILFGLFWALGYMLLALLAYLIRD---WRWLQLAISLPGLL-FLLLLWWLPRRT 165
|
|
| efflux_Bcr_CflA |
TIGR00710 |
drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a ... |
33-311 |
1.84e-08 |
|
drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 12 membrane-spanning regions. Members with known activity include Bcr (bicyclomycin resistance protein) in E. coli, Flor (chloramphenicol and florfenicol resistance) in Salmonella typhimurium DT104, and CmlA (chloramphenicol resistance) in Pseudomonas sp. plasmid R1033.
Pssm-ID: 273229 [Multi-domain] Cd Length: 385 Bit Score: 55.85 E-value: 1.84e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489738235 33 PLLVSNFHINLAQAGLTVSIYAIGIMIGAPVMTLLTGRLNRHRLMMLIMILFIIGNLLAASAPTFGVLLAGRVVAALAHG 112
Cdd:TIGR00710 29 PEIAADLSTPASIVQMTLTLYLLGFAAGQLLWGPLSDRYGRRPVLLLGLFIFALSSLGLALSNNIETLLVLRFVQAFGAS 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489738235 113 IFMTVASVIAADVVAPAKRASAIAIMFTGLTVATVTGVPLGTMIGQLGGWRWSFIFISMIGVIGLLADYWLIPRNLPLPS 192
Cdd:TIGR00710 109 AGSVISQALVRDIYPGEELSRIYSILMPVLALAPAVAPLLGGYILVWLSWHAIFAFLSLAGILLSALIFFILPETLPYEA 188
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489738235 193 KATVRGIIRVLTNP----QLLFALLVTALGYGGTFVVYTYLSPLLEQQMHWSASAVVLILVVYGLMVALGNTLGGRWANA 268
Cdd:TIGR00710 189 RIQISTYFETFLLLlkskMFWGYALIYGASFGGFFAFFSGAPFVYIDIMGVSPSVFGLLFALNIIAMIFGGFLNGRFIKK 268
|
250 260 270 280
....*....|....*....|....*....|....*....|...
gi 489738235 269 RPLIALFKMFSGLLITLLILSVTGYSHWLGLLTvLLMGIFAFM 311
Cdd:TIGR00710 269 WGAKSLLRMGLILFAVSAVLLEITAILGLGSWA-MIIGPMMFV 310
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
2-179 |
1.95e-08 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 55.63 E-value: 1.95e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489738235 2 TKQFNPSWTLFALAISAFAIGsteFISVGLMPLLVSNFHINLAQAGLTVSIYAIGIMIGAPVMTLLTGRLNRHRLMMLIM 81
Cdd:cd17370 195 LKKLPKAFWLYLLAVALFALG---NFSFAFLILRAQELGLSAALIPLLYALFNLVYALAAYPAGRLSDRIGRKKLLILGY 271
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489738235 82 ILFIIGNLLAASAPTFGVLLAGRVVAALAHGIFMTVASVIAADVVAPAKRASAIAIMFTGLTVATVTGVPLGTMIGQLGG 161
Cdd:cd17370 272 LSLALAYLGFALGSSLWLLLLGFILWGLYMGAQESIERAAVADLVPAELRGTAYGLFNTVVGIGWLLASLIAGYLWDLIS 351
|
170
....*....|....*...
gi 489738235 162 WRWSFIFISMIGVIGLLA 179
Cdd:cd17370 352 PSAAFLFSAVLALIALLL 369
|
|
| PRK11551 |
PRK11551 |
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional |
33-324 |
2.49e-08 |
|
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional
Pssm-ID: 236927 [Multi-domain] Cd Length: 406 Bit Score: 55.35 E-value: 2.49e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489738235 33 PLLVSNFHINLAQAGLTVSIYAIGIMIGAPVMTLLTGRLNRHRLMMLIMILFIIGNLLAASAPTFGVLLAGRVVAALAHG 112
Cdd:PRK11551 39 PRMAQEFGLDVAQMGWAFSAGILGLLPGALLGGRLADRIGRKRILIVSVALFGLFSLATAQAWDFPSLLVARLLTGVGLG 118
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489738235 113 IFMTVASVIAADVVAPAKRASAIAIMFTGLTVATVTGVPLGTMIGQLGGWRWSFIfismIGVIGLLADYWLIPRNLP--- 189
Cdd:PRK11551 119 GALPNLIALTSEAVGPRLRGTAVSLMYCGVPFGGALASVIGVLAAGDAAWRHIFY----VGGVGPLLLVPLLMRWLPesr 194
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489738235 190 -----LPSKATVRGIIRVLTNPQLLFALLVTALGYGGTFVVYTYL-----SPLLEQQMHWSASAVVLILvvYGLMVALGN 259
Cdd:PRK11551 195 afaqaAGAGKQRAPVLRALFGEGRATATLLLWISYFFTLIVLYFLlnwlpSLLVGQGLSRSQAGLVQIA--FNIGGALGS 272
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 489738235 260 TLGGRWAN-ARPLIALFKMFSGLLITLLILSVTGyshwlGLLTVLLMGIFAFMNVPGLQLYIVQLA 324
Cdd:PRK11551 273 LLIGALMDrLRPRRVVLLIYAGILASLAALAAAP-----SFAGMLLAGFAAGLFVVGGQSVLYALA 333
|
|
| MFS_GLUT10_12_Class3_like |
cd17362 |
Glucose transporter (GLUT) types 10 and 12, Class 3 GLUTs, and similar transporters of the ... |
39-185 |
3.80e-08 |
|
Glucose transporter (GLUT) types 10 and 12, Class 3 GLUTs, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of glucose transporter type 10, GLUT12, plant polyol transporters (PLTs), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340920 [Multi-domain] Cd Length: 389 Bit Score: 54.67 E-value: 3.80e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489738235 39 FHINLAQAGLTVSIYAIGIMIGAPVMTLLTGRLNRHRLMMLIMILFIIGNLLAASAPTFGVLLAGRVVAALAHGIFMTVA 118
Cdd:cd17362 34 YNLSSLQSGLVVSGSLLGALLGSLVAGALIDRLGRRKELILAALLYLVGSLVTGLAPSYPVLLVGRLIYGVGIGLAMHAA 113
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 489738235 119 SVIAADVVAPAKRASAIAIMFTGLTVATVTGVPLGT-MIGQLGGWRWSFIFISMIGVIGLLADYWLIP 185
Cdd:cd17362 114 PVYIAETSPSHIRGLLVSLKELFIVLGILLGYVSGYaFADVVGGWRYMYGLAAPPALLLGIGMWFLPP 181
|
|
| MFS_YajR_like |
cd17472 |
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux ... |
46-209 |
5.43e-08 |
|
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli inner membrane transport protein YajR and some uncharacterized multidrug-efflux transporters. YajR is a putative proton-driven major facilitator superfamily (MFS) transporter found in many gram-negative bacteria. Unlike most MFS transporters, YajR contains a C-terminal, cytosolic YAM domain, which may play an essential role for the proper functioning of the transporter. YajR-like transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341025 [Multi-domain] Cd Length: 371 Bit Score: 54.14 E-value: 5.43e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489738235 46 AGLTVSIYAIGIMIGAPVMTLLTGRLNRHRLMMLIMILFIIGNLLAASAPTFGVLLAGRVVAALahGIFMTVASVIAADV 125
Cdd:cd17472 34 IGLALGIYGLTQAIFQIPFGLLSDRIGRKPVILFGLLLFIAGSLLAAYATSIYGLILGRALQGS--GAISSVVMALLADL 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489738235 126 VAPAKRASAIAIMFTGLTVATVTGVPLGTMIGQLGGWRWSFIFISMIGVIGLLADYWLIPRNLPLP--SKATVRGIIRVL 203
Cdd:cd17472 112 TREENRTKAMALIGASIGIAFAISMVLGPLLAAHLGVSGLFLITAILSLVSLLILLFFVPDPPKIVqiSEKEKKKLKKLL 191
|
....*.
gi 489738235 204 TNPQLL 209
Cdd:cd17472 192 KNKRLL 197
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
11-183 |
1.11e-07 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 53.39 E-value: 1.11e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489738235 11 LFALAISAFAIGSTEFISVGLMPLLVSNFHINLAQAGLTVSIYAIGIMIGAPVMTLLTGRLNRHRLMMLIMILFIIGNLL 90
Cdd:cd06173 211 RLLLLALALFALLGGALTVLLPLLAKEVLGGGAAGYGLLLAAFGVGALLGALLLGRLSKRRRRGRLLLIGALLLGLALLV 290
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489738235 91 AASAPTFGVLLAGRVVAALAHGIFMTVASVIAADVVAPAKRASAIAIMFTGLTVATVTGVPLGTMIGQLGGWRWSFIFIS 170
Cdd:cd06173 291 LGLSPSLWLLLAALFLLGLAGGLFNVPLNTLLQLRVPDELRGRVFSVYNALNSGAMPLGALLAGLLADALGLSAVFLLAG 370
|
170
....*....|...
gi 489738235 171 MIGVIGLLADYWL 183
Cdd:cd06173 371 ALLLLAALLLLLL 383
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
13-179 |
1.51e-07 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 52.95 E-value: 1.51e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489738235 13 ALAISAFAIGSTEFISVGLMPLLVSNFHINLAQAGLTVSIYAIGIMIGAPVMTLLTGRLNRHRLMMLIMILFIIGNLLAA 92
Cdd:cd17477 192 LALLGAFVAGFLEGAFYSLLPLYGLRLGLSVAQAALLLAAFVLGGLLLQWPLGWLADRFDRRRVLLGCALLGALAALLLP 271
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489738235 93 SAPTFGVLLAGR--VVAALAHGIFmTVASVIAADVVAPAKRASAIAIMFTGLTVATVTGVPLGTMIGQLGGWRWSFIFIS 170
Cdd:cd17477 272 LVPGLPLALLVLlfLWGGAAGPLY-TLALALAGDRLPGDELVAANAALLLLYGLGSVIGPLLAGALMDAFGPHGLFLFLA 350
|
....*....
gi 489738235 171 MIGVIGLLA 179
Cdd:cd17477 351 AVALLFLLF 359
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
11-179 |
8.06e-07 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 50.65 E-value: 8.06e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489738235 11 LFALAISAFAIGSTEFISVGLMPLLVSNFHI-NLAQAGLTVSIYAIGIMIGAPVMTLLTGRLNRHRLMMLIMILFIIGNL 89
Cdd:cd17473 199 VLPIYFLAFLAMLLFYVIPIQLPFLLQERGGgSAALIGLALAIASLAGAIGALLFGRLKRRLGKRRLLAIGFALMALGFL 278
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489738235 90 LAASAPTFGVLLAGRVVAALAHGIFMTVASVIAADVVAPAKRASAIAI----MFTGLTVATVTGVPLGTMIGQLGG-WRW 164
Cdd:cd17473 279 LLALASGLWVVLLGAILAGLGFGLLLPTLNSWAMSLVPPELRGRAMGIvtsaFFLGQFLSPLVLGPLVNLTGGLSGaFLI 358
|
170
....*....|....*
gi 489738235 165 SFIFISMIGVIGLLA 179
Cdd:cd17473 359 LGVLALVLAIVLLLL 373
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
9-355 |
1.33e-06 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 49.96 E-value: 1.33e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489738235 9 WTLFALAISAFAIGSTEFIsvgLMPLLVSNFHINLAQAGLTVSIYAIGIMIGAPVMTLLTGRLNRHRLMMLIMILFIIGN 88
Cdd:cd17355 6 AVTFLILILSWGIRYYFGV---FIIPIIAEFGWSRAVISLAFTVGLLAFGLAQPFVGRLLDRFGPRRVMLLGLLLLAAGL 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489738235 89 LLAASAPTFGVL-LAGRVVAALAHGIFMTVASVIAADVVAPAKRASAIAIMFTGLTVATVTGVPLGTMIGQLGGWRWSFI 167
Cdd:cd17355 83 VLLALATSLWQLyLLWGLLGGGGAGTLAAVAFATVAAWWFERRRGLALGILTAGGGLGSLVFLPLGAALIEAFGWRTALL 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489738235 168 FISMIGVIGLLADYWLIPRNLPLPSKATVRGIIRVLTNPQLL-------FALLVTAL---GYGGTFVVYTYLSPLLEQQM 237
Cdd:cd17355 163 VLALLALLVLVPVLLLLRRRPADLALRAYDDASPASPGSTLKealrsasFWLLALAFflcGFAVVGLIVHLVPYLADRGI 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489738235 238 HWSASAVVLILVVYGLMVA--LGNTLGGRWANARPLIALFKMFsglLITLLILSVTGYSHWLGLLTVLLMGIFAFMNVPG 315
Cdd:cd17355 243 SPAAAAVALALIGLFNIVGrlLSGWLGDRYSPRRLLAASYALR---ALGLALLLLLPFPPLALLLFAALFGLGWGATVPL 319
|
330 340 350 360
....*....|....*....|....*....|....*....|
gi 489738235 316 LQLYIVQLAEqntPHDITMASALNISAFNVGIALGSGIGG 355
Cdd:cd17355 320 TAALAARYFG---ARSYGTLFGLVFAPHQLGSALGPWLGG 356
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
6-157 |
1.62e-06 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 49.90 E-value: 1.62e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489738235 6 NPSWTLFALAISAFAIGSTeFISVGLMPLLVSNFHINLAQAGLTVSIYAIGIMIGAPVMTLLTGRLNRHRLMMLIMILFI 85
Cdd:COG2211 227 NRPFLLLLLAYLLFFLALA-LVAALLLYYFKYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAA 305
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 489738235 86 IGNLLAASAP--TFGVLLAGRVVAALAHGIFMTVASVIAADVVAPAKRASAI---AIMFTGLTVATVTGVPLGTMIG 157
Cdd:COG2211 306 LGLLLLFFLGpgNLWLLLVLAALAGIGLGAILVLPWAMLADVVDYDEWKTGRrreGLYFGIFTFAIKLGQALAGALA 382
|
|
| MFS_GLUT_Class1_2_like |
cd17357 |
Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This ... |
47-183 |
2.16e-06 |
|
Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This subfamily includes Class 1 and Class 2 glucose transporters (GLUTs) including Solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1, also called glucose transporter type 1 or GLUT1), SLC2A2-5 (GLUT2-5), SLC2A7 (GLUT7), SLC2A9 (GLUT9), SLC2A11 (GLUT11), SLC2A14 (GLUT14), and similar proteins. GLUTs are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUTs 1-5 are the most thoroughly studied and are well-established as glucose and/or fructose transporters in various tissues and cell types. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340915 [Multi-domain] Cd Length: 447 Bit Score: 49.57 E-value: 2.16e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489738235 47 GLTVSIYAIGIMIGAPVMTLLTGRLNRHRLMMLIMILFIIGNLL---AASAPTFGVLLAGRVVAALAHGIFMTVASVIAA 123
Cdd:cd17357 52 SLIVSIFFIGGAIGSFISAFLANRFGRKNGLLISNALLVVSSLLmflSKSAKSPELLIFGRFLVGIACGLSTGFVPMYLQ 131
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 489738235 124 DvVAPAKRASAIAIMF-TGLTVATVTGVPLGT--MIGQLGGWRWSFIFISMIGVIGLLADYWL 183
Cdd:cd17357 132 E-ISPSELRGALGSLTqIGVTLGILLGQVFGLpsVLGTETLWPYLLFFPGIPALLQLAALPFF 193
|
|
| MFS_Set |
cd17471 |
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; ... |
14-377 |
2.88e-06 |
|
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; This family is composed of sugar transporters such as Escherichia coli Sugar efflux transporter SetA, SetB, SetC and other sugar transporters. SetA, SetB, and SetC are involved in the efflux of sugars such as lactose, glucose, IPTG, and substituted glucosides or galactosides. They may be involved in the detoxification of non-metabolizable sugar analogs. The Set family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341024 [Multi-domain] Cd Length: 371 Bit Score: 49.08 E-value: 2.88e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489738235 14 LAISAFAIGSTEFISVGLMPL-LVSNFHINLAQAGLTVSIYAI-GIMIGAPVMTLLTGRLNRHRLMMLIMILFIIGNLLA 91
Cdd:cd17471 1 LLLATLLTGLAGAFVLPYLSLfLTEELGASPLQIGIFMTLSALsGIVVSQWLGRLSDRGGDRKPLILLALLAGALGYLLF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489738235 92 ASAPTFGVLLAgrvVAALAHGIFMTVASVI------AADVVAPAKRASAIAIMFTGLTVATVTGVPLGTMIGQLGGWRWS 165
Cdd:cd17471 81 AFLRNYWVLLL---VGVVLLSLGAAAFPQLfalareYADRSSGRDATLFNSVLRAAFSLAWVIGPPLAFLLLDVLGFTGL 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489738235 166 FIFISMIGVIGLLADYWLIP-RNLPLPSKATVRGIIRVLTNPQLLFALLVTALGYGGTFVVYTYLSPLLEQQMHWSASAV 244
Cdd:cd17471 158 FLLAALLYLVVALLVLFLLPsVKPPAQKATPASSLVKAPVNRRLLLLFAAFTLLFAANSMYIIAMPLYVTNELGGSESWV 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489738235 245 VLILVVYGL-----MVALGNtLGGRWANARPLIalFKMFSGLLITLLILSVTGYSH--WLGLLTVLLMGIFAfmnvpGLQ 317
Cdd:cd17471 238 GLLFGLAAAleipiMLLAGL-LAKRFGKRRLLL--AGFLAGVLFYLGLALATSLWQliALQLLNAIFIGITA-----GLG 309
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|
gi 489738235 318 LYIVQlaeQNTPHDITMASALNISAFNVGIALGSGIGGQVTTNLGLGWTPIFGAIMVAVS 377
Cdd:cd17471 310 ISYFQ---DLMPGQPGLATTLYSNASRIGSLLGGLLAGVIAQYFGYRAVFLVCAVLALLA 366
|
|
| MFS_KgtP |
cd17367 |
Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters; This ... |
49-308 |
3.18e-06 |
|
Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters; This subfamily includes Escherichia coli alpha-ketoglutarate permease (KgtP) and similar proteins. KgtP is a constitutively expressed proton symporter that functions in the uptake of alpha-ketoglutarate across the boundary membrane. Also included is a putative transporter from Pseudomonas aeruginosa named dicarboxylic acid transporter PcaT. The KgtP subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340925 [Multi-domain] Cd Length: 407 Bit Score: 48.83 E-value: 3.18e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489738235 49 TVSIYAIGIM---IGAPVMTLLTGRLNRHRLMMLIMILFIIGNLLAASAPTFG--------VLLAGRVVAALAHGIFMTV 117
Cdd:cd17367 42 TAAVFAVGFLmrpIGGWLFGRLADRIGRRAALTLSVSLMAAGSLVIAVTPTYAtigiwapiILLLARLLQGLSVGGEYGT 121
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489738235 118 ASVIAADVVAPAKRA--------SAIAIMFTGLTVATVTGVPLGTMIGQLGGWRWSFIFISMIGVIGLLadywlIPRNLP 189
Cdd:cd17367 122 SATYLSEVAPPGRRGfyssfqyvTLIGGQLLALGVLLVLQHTLGEDQMAAWGWRIPFLLGGVLAVVVLW-----LRRGLE 196
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489738235 190 --------LPSKATVRGIIRVLTN--PQLLFALLVTALGYGGTFVVYTYLSPLLEQQMHWSASAVVLILVVYGLMVALGN 259
Cdd:cd17367 197 etesfeaiAESNEASAGTLRELRRhpRELLLVVGLTAGGTLAFYTWTTYLQKFLVNTAGFSKGDATWITTAALLVFMLLQ 276
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|..
gi 489738235 260 TLGGRWANA---RPLIALFKMFSGLLITLLILSVTGYSHWLGLLTVLLMGIF 308
Cdd:cd17367 277 PLGGRLSDRigrRPLLLFFGIGGTLATVPLLSALDHTDSPYTAFALVLVGLV 328
|
|
| MFS_MFSD6 |
cd17335 |
Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily ... |
31-376 |
1.15e-05 |
|
Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily domain-containing protein 6 (MFSD6) is also called macrophage MHC class I receptor 2 homolog (MMR2). It has been postulated as a possible receptor for human leukocyte antigen (HLA)-B62. MFSD6 is conserved through evolution and appeared before bilateral animals. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340893 [Multi-domain] Cd Length: 375 Bit Score: 47.19 E-value: 1.15e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489738235 31 LMPLLVSNFHINLAQAGLTVSIYAIGIMIGAPVMTLLTGRLNRHRLMMLIMILF--IIGNLLAASAPTFGVLLAGRVVAA 108
Cdd:cd17335 19 FLSVYLKQLGLSPTQIGILIGIRPFVRFLSAPLWGALADRFGKRKALLLLSLLAavLFFLSLFFVAQIFWLLLLLVILGA 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489738235 109 LAHGIFMTVASVIAADVVAPAKR-----------ASAIAIMFTGLTVatvtgvplgTMIGQLGGWRWSFIFISMIGVIGL 177
Cdd:cd17335 99 FFSAPVVPLVDSITLQYLGEERErygkqrlwgsiGFGIAALLVGILI---------DRSSTYKNYTIAFYVFAVLMLLAL 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489738235 178 LADYWLIPRNLPLPSKATVRGIIRVLTNPQLLFALLVTALGYGGTFVVYTYLSPLLeQQMHWSASAVVLILVVYGL---- 253
Cdd:cd17335 170 LLALKFPFRPKHPEPNENTGGLLALLRNPRVLAFLLVAFLMGFGHGLIYSFLFWHL-QDLGGSKTLIGLLWTVGVVseip 248
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489738235 254 MVALGNTLGGRWANARPLIAlfkmfsGLLITLLILSVTGYSH--WLGLLTVLLMGI-FAFMNVPGLQlYIVQLAEQNTph 330
Cdd:cd17335 249 FFFFSSRLIQRFGHVGLLYL------GLLAYVVRWLLYSFLEnpWLVLPIELLHGLtFALVWAAAVS-YASAAAPPGL-- 319
|
330 340 350 360
....*....|....*....|....*....|....*....|....*.
gi 489738235 331 DITMASALNISAFNVGIALGSGIGGQVTTNLGLGWTPIFGAIMVAV 376
Cdd:cd17335 320 RATAQGLLQGLYFGLGGGLGSLIGGYLYEAFGARTTFRFFAIAALA 365
|
|
| 2A0119 |
TIGR00898 |
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds] |
44-185 |
1.36e-05 |
|
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]
Pssm-ID: 273328 [Multi-domain] Cd Length: 505 Bit Score: 46.93 E-value: 1.36e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489738235 44 AQAGLTVSIYAIGIMIGAPVMTLLTGRLNRHRLMMLIMILFIIGNLLAASAPTFGVLLAGRVVAALAHGIFMTVASVIAA 123
Cdd:TIGR00898 127 WKVDLTQSCFFVGVLLGSFVFGYLSDRFGRKKVLLLSTLVTAVSGVLTAFSPNYTVFLVFRLLVGMGIGGIWVQAVVLNT 206
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 489738235 124 DVVAPAKRASAIAIMFTGLTVATVTGVPLGTMIGQlggWRWSFIFISMIGVIGLLAdYWLIP 185
Cdd:TIGR00898 207 EFLPKKQRAIVGTLIQVFFSLGLVLLPLVAYFIPD---WRWLQLAVSLPTFLFFLL-SWFVP 264
|
|
| TRI12 |
pfam06609 |
Fungal trichothecene efflux pump (TRI12); This family consists of several fungal specific ... |
46-295 |
1.42e-05 |
|
Fungal trichothecene efflux pump (TRI12); This family consists of several fungal specific trichothecene efflux pump proteins. Many of the genes involved in trichothecene toxin biosynthesis in Fusarium sporotrichioides are present within a gene cluster.It has been suggested that TRI12 may play a role in F. sporotrichioides self-protection against trichothecenes.
Pssm-ID: 115279 [Multi-domain] Cd Length: 598 Bit Score: 46.97 E-value: 1.42e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489738235 46 AGLTVSIYAIGIMIGAPVMTLLTGRLNRHRLMMLIMILFIIGNLLAASAPTFGVLLAGRVVAALAHGIfMTVASVIAADV 125
Cdd:pfam06609 80 QGLFSTLWTMGQAVSILMMGRLTDRFGRRPFVIATHIIGLVGAIVGCTANKFNTLLAAMTLLGVAAGP-AGASPLFIGEL 158
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489738235 126 VAPAKRASAIAIMFTGLTVATVTGVPLGTMIGQLGGWRWSF-IFISMIGVIGLLADYWLIPrnlplPSKATVRGiIRVLT 204
Cdd:pfam06609 159 MSNKTKFLGLLIVSAPTIAMNGAGPYFGQRLAIQGNWRWIFyIYIIMSAIAVLLIIIWYHP-----PSFAQLHG-KKARK 232
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489738235 205 NPQLlfallvTALGYGGTFVVYTYLSPLL-------EQQMHWSASAVVLI-------LVVYGLMVALGNTlggrwanARP 270
Cdd:pfam06609 233 RDEL------AKLDWIGIFLVIAGTSLFLlgvswggKPNNPWNSAKIIGLissgagsLVIFALYEVFGKP-------EQP 299
|
250 260
....*....|....*....|....*..
gi 489738235 271 LI--ALFKMFSGLLITLLILSVTGYSH 295
Cdd:pfam06609 300 IIppALFKDTRGFVCILIISSIMGAMH 326
|
|
| 2A0104 |
TIGR00881 |
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ... |
31-175 |
1.50e-05 |
|
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273319 [Multi-domain] Cd Length: 379 Bit Score: 46.60 E-value: 1.50e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489738235 31 LMPLLVSNFHINLAQAGLTVSIYAIGIMIGAPVMTLLTGRLNRHRLMMLIMILFIIGNLLAASAPTFGVLLAGRVVAALA 110
Cdd:TIGR00881 17 AMPYLVEEIGLSKTDLGLLLSSFSIAYGISKFVMGSVSDRSNPRVFLPIGLILCAIVNLFFGFSTSLWVMAALWALNGIF 96
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 489738235 111 HGIFMTVASVIAADVVAPAKRASAIAIMFTGLTVATVTGVPL-GTMIGQLGGWRWSFIFISMIGVI 175
Cdd:TIGR00881 97 QGMGWPPCGRTVTKWFSRSERGTWVSFWNCSHNVGGGLLPPLvLFGIAELYSWHWVFIVPGIIAII 162
|
|
| MFS_MosC_like |
cd17393 |
Membrane protein MosC and similar proteins of the Major Facilitator Superfamily of ... |
29-377 |
1.63e-05 |
|
Membrane protein MosC and similar proteins of the Major Facilitator Superfamily of transporters; The gene encoding Sinorhizobium meliloti membrane protein MosC is part of the mos locus, which encodes the biosynthesis of the rhizopine 3-O-methyl-scyllo-inosamine. MosC belongs to the bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4 (FucP/MFSD4) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340951 [Multi-domain] Cd Length: 373 Bit Score: 46.48 E-value: 1.63e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489738235 29 VGLMPLLVSNFHINLAQAGLTVSIYAIGIMIGAPVMTLLTGRLNRHRLMMLIMILFIIGNLLAASAPTFGVLLAGRVVAA 108
Cdd:cd17393 19 ATRIPAIKDRLGLSDAALGLLLLALGVGALVAMPLAGRLVARFGSRRVTRLGALLLLLALLLLGLAPSVPALALALFLFG 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489738235 109 LAHGIFMTVASVIAADVVAPAKRaSAIAIMFTGLTVATVTGVPLGTMIGQLG-GWRWSFIFISMIGVIGLLADYWLIPRN 187
Cdd:cd17393 99 AANGALDVAMNAQGVAVERAYGR-PIMSSLHAMWSLGGLAGALLGAAAIGAGvSPGVHLLAAAVLLLLAALVAIRALLPG 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489738235 188 LPL---PSKATVRGIIRVLTNPQLLFALLVTALGYGGTFVVYTYLSPLLEQQMHWSASAVVLILVVYGLMVALGNTLGGR 264
Cdd:cd17393 178 TGEaaeDRPDGAGKPGFLLPNRLLLLLGLLALAAALAEGAAADWSALYLRDVLGASAALAALGYAVFSLAMTVGRLFGDR 257
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489738235 265 WANARPLIALFKMFSGLLITLLILSVTGYSHWLGLLTVLLMGIFAFMNVPGLQLYIVQLAEQNTPHDITMASALNISAFN 344
Cdd:cd17393 258 LVDRFGDVAVLRAGALLAALGLLLALLAPSVWVALAGFALMGLGLSVVVPLAFSAAGALPGLAAGIAVARVATLGYLGFL 337
|
330 340 350
....*....|....*....|....*....|...
gi 489738235 345 VGIALGSGIGGQVTTNLGLGWTPIFGAIMVAVS 377
Cdd:cd17393 338 VGPPLIGFLADATGLRTAFLVVALLALLVALLA 370
|
|
| MFS_TRI12_like |
cd06179 |
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; ... |
44-222 |
2.39e-05 |
|
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; This family includes Fusarium sporotrichioides trichothecene efflux pump (TRI12), which may play a role in F. sporotrichioides self-protection against trichothecenes. TRI12 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340868 [Multi-domain] Cd Length: 518 Bit Score: 46.47 E-value: 2.39e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489738235 44 AQAGLTVSIYAIGIMIGAPVMTLLTGRLNRHRLMMLIMILFIIGNLLAASAPTFGVLLAGRVVAALAHGIfMTVASVIAA 123
Cdd:cd06179 32 SNSTWISTAWSLAQAVLGPIVGRLSDLFGRRWFFIGGNLLGVVGSIVAGTAKSVNMLIGGQALIGIGAGT-QGLGAAVAS 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489738235 124 DVVAPAKRASAIAIMFTGLTVATVTGVPLGT--MIGQLGGWRWSF---IFISMIGVIGLLADYWliPRNLPLPSKATVRG 198
Cdd:cd06179 111 ELVPNKYRGLVQGVVNLVASPGSALGPLIAGalVEANAAGWRWIFyinAIFNALALILLFFFYH--PPPRPQLHGSSTRQ 188
|
170 180
....*....|....*....|....*....
gi 489738235 199 IIRVLTNPQLLF-----ALLVTALGYGGT 222
Cdd:cd06179 189 KLKRLDWVGLFLliaglVLFLLGLSWGGN 217
|
|
| MFS_4 |
pfam06779 |
Uncharacterized MFS-type transporter YbfB; This family represents putative bacterial membrane ... |
17-350 |
2.64e-05 |
|
Uncharacterized MFS-type transporter YbfB; This family represents putative bacterial membrane proteins which may be sugar transporters. Members carry twelve transmembrane regions which are characteriztic of members of the major facilitator sugar-transporter superfamily.
Pssm-ID: 399632 [Multi-domain] Cd Length: 365 Bit Score: 45.82 E-value: 2.64e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489738235 17 SAFAIGSTEFISVGLMPLLVSNFHINLAQAGLTVSIYAIGIMIGAPVMTLLTGRLNRHRLMMLIMILFIIGNLLAASAPT 96
Cdd:pfam06779 1 LTVGMGIGRFSYTPILPVMIAEGQFSLSQAGLLAAANYAGYLAGALLASFAWRHGASRLRPALLAGLLATVLLLLAMAAT 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489738235 97 --FGVLLAGRVVAALAHGIFMTVASVIAADVVAPAKRASAIAIMFTGLTV---ATVTGVPLGTMIGQLGGWRWsfIFISM 171
Cdd:pfam06779 81 ssFWAVLLIRFLAGVASAAVMIFGSSLILGHATAARRAFVGALLFAGVGIgiaLSGLLVPLGLQLGLGGSSLW--YGAGV 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489738235 172 IGVIGLLADYWLIPRNLPLPSKATVrgiiRVLTNPQLLFALLVTALGYG----GTFVVYTYLSPLLEQQMHwSASAVVLI 247
Cdd:pfam06779 159 LSAVLTLAVFPLLPRRAPRHASAPA----PAAKPLQRSLPLWILTLAYGlagfGYIITATFLPAMARDGFG-GPAAAALF 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489738235 248 LVVYGLMVALGNTL----GGRWANARPLIALFKMFS-GLLITLLILSVTGYshwlgLLTVLLMGIFAFMNVPglqlYIVQ 322
Cdd:pfam06779 234 WSLFGLAAALGVLVwlraAKRWGTRPALTAALLIQAlGVLLSLLSPSPAGL-----AVSSLLFGGTFMAITS----LVMQ 304
|
330 340
....*....|....*....|....*...
gi 489738235 323 LAEQNTPHDITMASALNISAFNVGIALG 350
Cdd:pfam06779 305 LARELAPPAPRRLLGLMTASFGIGQILG 332
|
|
| MFS_SLC22A18 |
cd17331 |
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; ... |
26-311 |
3.79e-05 |
|
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 18 (SLC22A18) is also called Beckwith-Wiedemann syndrome chromosomal region 1 candidate gene A protein (BWR1A or BWSCR1A), efflux transporter-like protein, imprinted multi-membrane-spanning polyspecific transporter-related protein 1 (IMPT1), organic cation transporter-like protein 2 (ORCTL2), or tumor-suppressing subchromosomal transferable fragment candidate gene 5 protein (TSSC5). It is localized at the apical membrane surface of renal proximal tubules and may act as an organic cation/proton antiporter. It functions as a tumor suppressor in several cancer types including glioblastoma and colorectal cancer. SLC22A18 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340889 [Multi-domain] Cd Length: 382 Bit Score: 45.29 E-value: 3.79e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489738235 26 FISVGLMPLLVSNFHINLAQAGLTVSIYAIGIMIGAPVMTLLTGRLNRHRLMMLIMILFIIGNLLAASAPTFGVLLAGRV 105
Cdd:cd17331 17 WLQQPVLPYLTKKLGVDSVVFGYLQTTFSVLQLVGGPLFGRFGDLFGPRAALVLSFLSSALSYLLLAFASSVPMLFLSRL 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489738235 106 VAALAHGifMTVASVIAADVVAPAKRASAIAIMFTGLTVATVTGVPLGTMIGQLGGWRWSFIFISMIGVIGLLADYWLIP 185
Cdd:cd17331 97 PSVFMHA--MQAAQMVVTDLTDPGERAAALGRLGLSYGIGMVVGSFLGGLLTKKFGEQAAALVAAVGSLLSIVLVILLIP 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489738235 186 ------------RNLPLPSKATVRGIIRVLTNPQLLFALLVTALGYGGTFVVYTYLSPLLEQQMHWSASAVVLILVVYGL 253
Cdd:cd17331 175 sntkskrekeakESASPPSVFNLKEILRLLRLPGVAFLLLVKLLSGLPIGMFQSMFSLVAMDFFGLTPEENGYLMSYAGV 254
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 489738235 254 MVALGNTLGgrwanARPLIALFKMFSgLLITLLILSVTGY-------SHWLGLLTVLLMGIFAFM 311
Cdd:cd17331 255 LGMVVQGLL-----VGPLTKRFGERS-LLKLSVALLAIGYlllafvtTVWQLLVLLLPLVIGGSV 313
|
|
| MFS_SLC18B1 |
cd17385 |
Solute carrier family 18 member B1 of the Major Facilitator Superfamily of transporters; ... |
44-377 |
3.95e-05 |
|
Solute carrier family 18 member B1 of the Major Facilitator Superfamily of transporters; Solute carrier family 18 member B1 (SLC18B1) is the fourth member of the SLC18 transporter family, which includes vesicular monoamine transporters and vesicular acetylcholine transporter. It is predominantly expressed in the hippocampus and is associated with vesicles in astrocytes. It actively transports spermine and spermidine by exchange of H(+), and has been suggested to be a vesicular polyamine transporter (VPAT). SLC18B1 belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340943 [Multi-domain] Cd Length: 390 Bit Score: 45.29 E-value: 3.95e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489738235 44 AQAGLTVSIYAIGIMIGAPVMTLLTGRLNRhRLM----MLIM----ILFIIGNLLAASAPTFGVLLAGRVVAALAHGIFM 115
Cdd:cd17385 34 TIIGLVFGCFALVIFLTSPIFGKYLVKIGA-KFMfvagMFVSggctILFGFLDRVPDGTVFIALCFLVRIVEAVGFAAFI 112
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489738235 116 TVASVIAADVVaPAKRASAIAIM--FTGLtvATVTGVPLGTMIGQLGGWRWSFIFISMIGVIGLLADYWLIPRNLPLPSK 193
Cdd:cd17385 113 TASFAIIAKEF-PNNIATVLGTLetFSGL--GLMLGPPLGGFLYQAGGYELPFLVLGCLLLLTVPLNMFILPRYDDDPSP 189
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489738235 194 ATVrGIIRVLTNPQLLFALLVTALGYggtfVVYTYLSPLLEQ---QMHWSASAVVLILVVYGLMVALGNTLGGrWANARP 270
Cdd:cd17385 190 KSG-SMLKLLKIPSVLLLCLSIVSGS----VSLGFLDPTLSPhlrQFKLSPGQVGLMFLILAGSYAISAPLWG-WLSDKK 263
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489738235 271 LIALFKMFSGLLITLLILSVTGYSH--------WLGLLTVLLMGIFAFMN-VPGLQLYIVQLAEQNTPHDIT---MASAL 338
Cdd:cd17385 264 KIPKWLMVIGSIITGVGFLLLGPAPllpikselWMVIIGLVLLGLSLGAAlVPTFPELLNCAREYGFPDNLStygLVSGL 343
|
330 340 350
....*....|....*....|....*....|....*....
gi 489738235 339 NISAFNVGIALGSGIGGQVTTNLGLGWTPIFGAIMVAVS 377
Cdd:cd17385 344 FNAAFSLGAFIGPTLGGFLLERLGFEWAATIQAGLAFVV 382
|
|
| OATP |
pfam03137 |
Organic Anion Transporter Polypeptide (OATP) family; This family consists of several ... |
11-330 |
4.69e-05 |
|
Organic Anion Transporter Polypeptide (OATP) family; This family consists of several eukaryotic Organic-Anion-Transporting Polypeptides (OATPs). Several have been identified mostly in human and rat. Different OATPs vary in tissue distribution and substrate specificity. Since the numbering of different OATPs in particular species was based originally on the order of discovery, similarly numbered OATPs in humans and rats did not necessarily correspond in function, tissue distribution and substrate specificity (in spite of the name, some OATPs also transport organic cations and neutral molecules). Thus, Tamai et al. initiated the current scheme of using digits for rat OATPs and letters for human ones. Prostaglandin transporter (PGT) proteins are also considered to be OATP family members. In addition, the methotrexate transporter OATK is closely related to OATPs. This family also includes several predicted proteins from Caenorhabditis elegans and Drosophila melanogaster. This similarity was not previously noted. Note: Members of this family are described (in the Swiss-Prot database) as belonging to the SLC21 family of transporters.
Pssm-ID: 460821 [Multi-domain] Cd Length: 526 Bit Score: 45.27 E-value: 4.69e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489738235 11 LFALAISAFAIGSTEFISVglMPLLVSNFHINLAQAGLTVSIYAIGIMIGAPVMTLLTGRLNRHRLMMLIMILFIIGNLL 90
Cdd:pfam03137 5 FLSLLGLAQALVSGYFNSS--ITTIEKRFGLPSSLSGLISSSYDIGNLLLIVFVSYFGGKGHRPRWIGVGALLMGLGSLL 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489738235 91 AASaPTFGVLLAGRVVAALAHGIFMTVASVIAADVVAPAKRASAIAIMFTgltvATVTGVPLGTMIG------------- 157
Cdd:pfam03137 83 FAL-PHFLSFFLGQLLLGIGGTPIYTLGISYIDDNVKKKNSPLYLGILYA----VRVLGPALGFLLGslclriyvdigkv 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489738235 158 ----------QLGGWrWSFIFISMIGVIGLLADYWLIPRNLPLPSK---------------------------ATVRGII 200
Cdd:pfam03137 158 sitltpkdprWVGAW-WLGFLIAGLLLLLTAIPFFFFPKSLPGAAKrrakkkkephsqdiadlkktkslkklgPSLKDFP 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489738235 201 RV----LTNPQLLFALLVTALGYGGTFVVYTYLSPLLEQQMHWSAS-AVVLILVVYGLMVALGNTLGGRwanarpLIALF 275
Cdd:pfam03137 237 KAlkrlLKNPVYMLLTLASVFEFLLIAGYATFLPKYIETQFGLSAStANLLTGVVAIPGAALGILLGGL------IIKKF 310
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*
gi 489738235 276 KMfSGLLITLLILsvtgyshWLGLLTVLLMGIFAFMNVPGLQLYIVQLAEQNTPH 330
Cdd:pfam03137 311 KL-SAKGLAKFNV-------ITSLVSLLLSLLLFFLGCPNSPVAGITVPYGGTQQ 357
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
208-394 |
1.12e-04 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 43.81 E-value: 1.12e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489738235 208 LLFALLVTALGYGGTFVVYTYLSPLLEQQMHWSASAVVLILVVYGLMVALGNTLGGRWANARPLIALFKMFSGLLITLLI 287
Cdd:COG2814 11 ALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSL 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489738235 288 LSVTGYSHWLGLLTVLLMGIFAFMNVPGLQLYIVQLAeqnTPHDITMASALNISAFNVGIALGSGIGGQVTTNLGLGWTP 367
Cdd:COG2814 91 LCALAPSLWLLLAARFLQGLGAGALFPAALALIADLV---PPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWRWVF 167
|
170 180
....*....|....*....|....*..
gi 489738235 368 IFGAIMVAVSLVLLLGLIWLARPAKST 394
Cdd:COG2814 168 LVNAVLALLALLLLLRLLPESRPAARA 194
|
|
| MFS_Set |
cd17471 |
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; ... |
7-178 |
1.26e-04 |
|
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; This family is composed of sugar transporters such as Escherichia coli Sugar efflux transporter SetA, SetB, SetC and other sugar transporters. SetA, SetB, and SetC are involved in the efflux of sugars such as lactose, glucose, IPTG, and substituted glucosides or galactosides. They may be involved in the detoxification of non-metabolizable sugar analogs. The Set family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341024 [Multi-domain] Cd Length: 371 Bit Score: 43.69 E-value: 1.26e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489738235 7 PSWTLFALAISAFAIGSTEFISVGLMPLLVSN-FHINLAQAGLTVSIYA---IGIMIGAPvmtLLTGRLNRHRLMMLIMI 82
Cdd:cd17471 197 VNRRLLLLFAAFTLLFAANSMYIIAMPLYVTNeLGGSESWVGLLFGLAAaleIPIMLLAG---LLAKRFGKRRLLLAGFL 273
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489738235 83 LFIIGNLLAASAPTFGVLLAGRVVAALAHGIFMTVASVIAADVVaPAKRASAIAIMFTGLTVATVTGVPLGTMIGQLGGW 162
Cdd:cd17471 274 AGVLFYLGLALATSLWQLIALQLLNAIFIGITAGLGISYFQDLM-PGQPGLATTLYSNASRIGSLLGGLLAGVIAQYFGY 352
|
170
....*....|....*.
gi 489738235 163 RWSFIFISMIGVIGLL 178
Cdd:cd17471 353 RAVFLVCAVLALLALV 368
|
|
| MFS_MFSD9 |
cd17390 |
Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily ... |
31-304 |
2.72e-04 |
|
Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily domain-containing protein 9 (MFSD9) is expressed in the central nervous system (CNS) and in most peripheral tissues but at very low expression levels. The function of MFSD9 is unknown. MFSD9 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340948 [Multi-domain] Cd Length: 350 Bit Score: 42.60 E-value: 2.72e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489738235 31 LMPLLVSNFHINLAQAGLTVSIYAIGIMIGAPVMTLLTGRLNRHRLMMLIMILFIIGNLLAASAPTFGVLLAGRVVAala 110
Cdd:cd17390 18 LLSTHIRSLGASPTVIGLIGSVYGALQLFSSPLVGSWSDVVGRRPVLLICLLLTALGYVLLGFSTSLALLFLSRIPL--- 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489738235 111 hGIF---MTVASVIAADVVAPAKRASAI----AIMFTGLTVATVTGvplGTMIGQLGGWRWSFIFISMIGVIGLLADYWL 183
Cdd:cd17390 95 -GIFkhtQSLCKAYLSDLVSEQERSRVLgrfnAASSLGFILGPVVG---GHLAETDGGFYYVALLCSAIFILNAGLVWFL 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489738235 184 IPRnlplpskatvrgiIRVLTNPQLLFALLVTalgyggtfVVYTYLSPLLEQQMHWSASAVVLILVVYGLMVALGNTLGG 263
Cdd:cd17390 171 LSK-------------LWDLLLVRFLMGFSVL--------LFRSNFSLYLEERFDLSPKTIGYLISYSGVLGALSGFLVG 229
|
250 260 270 280
....*....|....*....|....*....|....*....|....
gi 489738235 264 RWANARP---LIALFKMFSGLLITLLILSVTGYSHWLGLLTVLL 304
Cdd:cd17390 230 RILKLYKnneYLLLLHSFILLALSLLGLALAPSIWLLVLCLTPL 273
|
|
| MFS_HMIT_like |
cd17360 |
H(+)-myo-inositol cotransporter and similar transporters of the Major Facilitator Superfamily; ... |
48-179 |
2.98e-04 |
|
H(+)-myo-inositol cotransporter and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of myo-inositol/inositol transporters and similar transporters from vertebrates, plant, and fungi. The human protein is called H(+)-myo-inositol cotransporter/Proton myo-inositol cotransporter (HMIT), or H(+)-myo-inositol symporter, or Solute carrier family 2 member 13 (SLC2A13). HMIT is classified as a Class 3 GLUT (glucose transporter) based on sequence similarity with GLUTs, but it does not transport glucose. It specifically transports myo-inositol and is expressed predominantly in the brain, with high expression in the hippocampus, hypothalamus, cerebellum and brainstem. HMIT may be involved in regulating processes that require high levels of myo-inositol or its phosphorylated derivatives, such as membrane recycling, growth cone dynamics, and synaptic vesicle exocytosis. Arabidopsis Inositol transporter 4 (AtINT4) mediates high-affinity H+ symport of myo-inositol across the plasma membrane. The HMIT-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340918 [Multi-domain] Cd Length: 362 Bit Score: 42.64 E-value: 2.98e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489738235 48 LTVSIYAIGIMIGAPVMTLLTGRLNRHRLMMLIMILFIIGNLLAASAPTFGVLLAGRVVAALAHGIFMTVASVIAADVVA 127
Cdd:cd17360 39 LIVSSTVAGAAVGAAIGGWLNDRFGRRPCILLADALFTIGAIVMAAAPNKEVLIVGRVLVGLGVGIASMTVPLYIAEAAP 118
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|...
gi 489738235 128 PAKRASAIAIMFTGLTVATVTGVPLGTMIGQL-GGWRWsfifisMIGVIGLLA 179
Cdd:cd17360 119 PRIRGRLVTINVLFITGGQFVAYVINGAFSYLpGGWRW------MLGLAAVPA 165
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
10-183 |
3.32e-04 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 42.60 E-value: 3.32e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489738235 10 TLFALAISAFAIGSTEFiSVGLMPLLVSNFHINLAQAGLTVSIYAIGIMIGAPVMTLLTGRLNRHRLMMLIMILFIIGNL 89
Cdd:cd17329 203 LLFLLASFLISLIYFQL-ESTLPVYVVEILGLGESLLGLLLALNALLIVLLQFPVARLVERFRLRKILMIGILLFAIGFA 281
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489738235 90 LAASAPTFGVLLAGRVVAALAHGIFMTVASVIAADVVAPAKRASAIAIMFTGLTVATVTGVPLGTMIGQLGGWRWSFIFI 169
Cdd:cd17329 282 VLAFANTLAVLILAMIVLTLGEMLVFPAVQTLVAALAPPDKRGSYMGFYALAWGLGRAIGPLVGGLLLDLLGPGLPWLIL 361
|
170
....*....|....
gi 489738235 170 SMIGVIGLLADYWL 183
Cdd:cd17329 362 AALGLIAAALLLGL 375
|
|
| MFS_OAT |
cd17374 |
Organic anion transporters of the Major Facilitator Superfamily of transporters; Organic anion ... |
48-188 |
3.33e-04 |
|
Organic anion transporters of the Major Facilitator Superfamily of transporters; Organic anion transporters (OATs) generally display broad substrate specificity and they facilitate the exchange of extracellular with intracellular organic anions (OAs). Several OATs have been characterized including OAT1-10 and urate anion exchanger 1 (URAT1, also called SLC22A12). Many OATs occur in renal proximal tubules, the site of active drug secretion. OATs mediate the absorption, distribution, and excretion of a diverse array of environmental toxins, and clinically important drugs, including anti-HIV therapeutics, anti-tumor drugs, antibiotics, anti-hypertensives, and anti-inflammatories, and therefore is critical for the survival of the mammalian species. OAT falls into the SLC22 (solute carrier 22) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340932 [Multi-domain] Cd Length: 341 Bit Score: 42.28 E-value: 3.33e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489738235 48 LTVSIYAIGIMIGAPVMTLLTGRLNRHRLMMLIMILFIIGNLLAASAPTFGVLLAGRVVAALAHGIFMTVASVIAADVVA 127
Cdd:cd17374 39 VAQSIFMAGLLVGALIFGHLSDRFGRKFILLLSLLQLAIFGTCAAFAPTFPVYCVLRFLAGFAVSGISINTLILGTEWTT 118
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 489738235 128 PAKRasAIAIMFTGLTVAtvtgvpLGTMIgqLGG-------WRWSFIFISMIGVIGLLADYWLIPRNL 188
Cdd:cd17374 119 PRHR--ALAITLTSCFFS------IGQML--LAGlayairdWRLLQLVVSVPFFLFFLYSWWLPKRTL 176
|
|
| MFS_GLUT_Class2 |
cd17432 |
Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; GLUTs, also called ... |
48-183 |
3.50e-04 |
|
Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT5, also called Solute carrier family 2, facilitated glucose transporter member 5 (SLC2A5), is a well-established fructose transporter found in the small intestine. GLUT7 (or SLC2A7) is a high-affinity glucose and fructose transporter expressed in the small intestine and colon. GLUT9 (or SLC2A9) transports urate and fructose, and is most strongly expressed in the basolateral membranes of proximal renal tubular cells, liver and placenta. It may play a role in urate reabsorption by proximal tubules. GLUT11 (or SLC2A11) is a facilitative glucose transporter expressed in heart and skeletal muscle. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340990 [Multi-domain] Cd Length: 452 Bit Score: 42.60 E-value: 3.50e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489738235 48 LTVSIYAIGIMIGAPVMTLLTGRLNRHRLMMLIMILFIIGNLLAA---SAPTFGVLLAGRVVAALAHGIFMTVASVIAAD 124
Cdd:cd17432 54 LTVSIFPLGGLFGSLLVGPLVIRLGRKGTLLLNNIFAIVAAILMGlskIAKSFEMIIVGRFLVGINAGISLNVVPMYLGE 133
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 489738235 125 vVAPAKRASAIAIMFT-----GLTVATVTGVPlgTMIGQLGGWRWSFIFISMIGVIGLLADYWL 183
Cdd:cd17432 134 -SAPKNLRGAVGLVPAifitlGILLGQVLGLR--ELLGNEEGWPLLLALTGVPALLQLLTLPFF 194
|
|
| MFS_OFA_like |
cd17353 |
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ... |
33-183 |
4.13e-04 |
|
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340911 [Multi-domain] Cd Length: 389 Bit Score: 42.21 E-value: 4.13e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489738235 33 PLLVSNFHINLAQAGLTVSIYAIGIMIGAPVMTLLTGRLNRHRLMMLIMILFIIGNLLAASAP-TFGVLLAGRVVAALAH 111
Cdd:cd17353 238 PIGQEFAGLDAGIAALAVSILSIFNGGGRPFWGWLSDKIGRKNTLSIAFLIQGVAMFLLPFIGsVAVLFVLGVALIGFCY 317
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 489738235 112 GIFMTVASVIAADVVAPAKRASAIAIMFTGLTVATVTGVPLGTMIGQLGGWRWSFIFISMIGVIGLLADYWL 183
Cdd:cd17353 318 GGGFALFPALTADFFGTKNAGTNYGLLYTAKGVGGLIGPIIAAYVLYTGGYNAAFIIAAALSLVALALALLL 389
|
|
| MFS_MdtG_MDR_like |
cd17391 |
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ... |
46-377 |
6.10e-04 |
|
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340949 [Multi-domain] Cd Length: 380 Bit Score: 41.48 E-value: 6.10e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489738235 46 AGLTVSIYAIGIMIGAPVMTLLTGRLNRHRLMMLIMILFIIGNLLAASAPTFGVLLAGRVVAALAHGiFMTVASVIAADV 125
Cdd:cd17391 38 SGLAFSSTFLVSAIFSPIWGRLADRYGRKPMLLRASLGMAIVIGLMAFVTNVWQLLILRLLQGVFSG-YVPNATALIASQ 116
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489738235 126 VAPAKRASAIAIMFTGLTVATVTGVPLGTMIGQLGGWRWSFIFISMIGVIGLLADYWLIPRNLPLPSKAT---VRGIIRV 202
Cdd:cd17391 117 TPKEKSGWALGTLSTGVVAGTLIGPLLGGFLADLFGIRNVFFITGGLLFLAFLLTLFFVKEDFKPVEKKKmvsTKEVWNS 196
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489738235 203 LTNPQLLFALLVTALGYGGTFVVYTYLSPLLEQQMHWSASAVVLILVVYGLMVALGNT--------LGGRWANARpLIAL 274
Cdd:cd17391 197 VPNPSLLISLFVTTFIIQLANQSIEPILTLYIRQLMGDASNLAFISGLVFSATGVSSLlsaprlgkLGDRIGHHR-ILLG 275
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489738235 275 FKMFSGLLitlLILSVTGYSHWLGLLTVLLMGifafMNVPGLQLYIVQLAEQNTPHDIT-MASALNISAFNVGIALGSGI 353
Cdd:cd17391 276 ALLASALL---YIPQAFVQTPWQLGILRFLLG----LATGGLLPAINSLLAKITPKEVAgRIFGYNQSFQYLGNVAGPLL 348
|
330 340
....*....|....*....|....
gi 489738235 354 GGQVTTNLGLGWTPIFGAIMVAVS 377
Cdd:cd17391 349 GSAIAAHFGYRAVFVVTALLVLLN 372
|
|
| MFS_HXT |
cd17356 |
Fungal Hexose transporter subfamily of the Major Facilitator Superfamily of transporters and ... |
36-146 |
6.96e-04 |
|
Fungal Hexose transporter subfamily of the Major Facilitator Superfamily of transporters and similar proteins; The fungal hexose transporter (HXT) subfamily is comprised of functionally redundant proteins that function mainly in the transport of glucose, as well as other sugars such as galactose and fructose. Saccharomyces cerevisiae has 20 genes that encode proteins in this family (HXT1 to HXT17, GAL2, SNF3, and RGT2). Seven of these (HXT1-7) encode functional glucose transporters. Gal2p is a galactose transporter, while Rgt2p and Snf3p act as cell surface glucose receptors that initiate signal transduction in response to glucose, functioning in an induction pathway responsible for glucose uptake. Rgt2p is activated by high levels of glucose and stimulates expression of low affinity glucose transporters such as Hxt1p and Hxt3p, while Snf3p generates a glucose signal in response to low levels of glucose, stimulating the expression of high affinity glucose transporters such as Hxt2p and Hxt4p. Schizosaccharomyces pombe contains eight GHT genes (GHT1-8) belonging to this family. Ght1, Ght2, and Ght5 are high-affinity glucose transporters; Ght3 is a high-affinity gluconate transporter; and Ght6 high-affinity fructose transporter. The substrate specificities for Ght4, Ght7, and Ght8 remain undetermined. The HXT subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340914 [Multi-domain] Cd Length: 403 Bit Score: 41.47 E-value: 6.96e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489738235 36 VSNFHINLA-QAGLTVSIYAIGIMIGAPVMTLLTGRLNRHRLMMLIMILFIIGNLL-AASAPTFGVLLAGRVVAALAHGI 113
Cdd:cd17356 36 NTGTYYPSSsRQGLIVSIVNLGSFFGALISSFLSDRIGRKKSIQIGCVIYIIGAIIqVAAIGKWYQLIVGRIIAGLGVGF 115
|
90 100 110
....*....|....*....|....*....|...
gi 489738235 114 FMTVASVIAADVVAPAKRASAIAIMFTGLTVAT 146
Cdd:cd17356 116 ASVLVPVYQSEVAPKHIRGTLVSLYQLAITIGI 148
|
|
| PRK03893 |
PRK03893 |
putative sialic acid transporter; Provisional |
7-249 |
7.18e-04 |
|
putative sialic acid transporter; Provisional
Pssm-ID: 179668 [Multi-domain] Cd Length: 496 Bit Score: 41.61 E-value: 7.18e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489738235 7 PSWTLFALAISAFAIGSTEFISVGL-MPLLVSNFHINLAQAGLTVSIYAIGIMIGAPVMTLLTGRLNRHRLMMLIMILFI 85
Cdd:PRK03893 17 AQWKAFSAAWLGYLLDGFDFVLITLvLTEVQGEFGLTTVQAASLISAAFISRWFGGLLLGAMGDRYGRRLAMVISIVLFS 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489738235 86 IGNLLAASAPTFGVLLAGRVVAALAHGIFMTVASVIAADVVAPAKRASAIAIMFTGLTVATVTGVPLGTMIGQLGGWRWS 165
Cdd:PRK03893 97 VGTLACGFAPGYWTLFIARLVIGMGMAGEYGSSATYVIESWPKHLRNKASGFLISGFSIGAVVAAQVYSLVVPVWGWRAL 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489738235 166 FIfismIGVIGLLADYWLiPRNLPLPS--KATVRGIIRVLTNPQLLFA-------LLVTALGYGGTFVVYTYlsplleqq 236
Cdd:PRK03893 177 FF----IGILPIIFALWL-RKNLPEAEdwKEKHAGKAPVRTMVDILYRgehriinILLTLAAAAALWFCFAG-------- 243
|
250
....*....|...
gi 489738235 237 mhWSASAVVLILV 249
Cdd:PRK03893 244 --NLQNAAIVAVL 254
|
|
| MFS_FucP_MFSD4_like |
cd17333 |
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ... |
2-178 |
7.87e-04 |
|
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340891 [Multi-domain] Cd Length: 372 Bit Score: 41.15 E-value: 7.87e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489738235 2 TKQFNPSWTLFALAISAFAIGSTEFISVgLMPLLVSNFHINLAQAGLTVSIYAIGIMIGAPVMTLLTGRLNRHRLMMLIM 81
Cdd:cd17333 194 RLLRNPSIILGALALFLYVGAETAFSSW-VPSYLVEKKHVSDGLAGYLLSGFWVGITIGRLLGGPISRRIKPHTLLVLSG 272
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489738235 82 ILFIIGNLLAASAPTFGVLLAGRVVAALAHGIFMTVASVIAADVVaPAKRASAIAIMFTGLTVATVTGVPLGTMIGQLGG 161
Cdd:cd17333 273 SGALLGLLILLLAPTLVVGLVATALLGLFMAALFPTILSLGISNL-PYAKGKGTSVLLAAGSIGGAIIPFIMGFIAEAVG 351
|
170
....*....|....*..
gi 489738235 162 WRWSFIFISMIGVIGLL 178
Cdd:cd17333 352 IQTAMLLITILYAIIFV 368
|
|
| MFS_MFSD10 |
cd17389 |
Major facilitator superfamily domain-containing protein 10; Major facilitator superfamily ... |
47-157 |
7.88e-04 |
|
Major facilitator superfamily domain-containing protein 10; Major facilitator superfamily domain-containing protein 10 (MFSD10) is also called tetracycline transporter-like protein (TETRAN). It is expressed in various human tissues, including the kidney. In cultured cells, its overexpression facilitated the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs). MFSD10/TETRAN overexpression cause resistance to some NSAIDs, suggesting that it may be an organic anion transporter that serves as an efflux pump for some NSAIDs and various other organic anions at the final excretion step. MFSD10 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340947 [Multi-domain] Cd Length: 391 Bit Score: 41.49 E-value: 7.88e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489738235 47 GLTVSIYAIGIMIGAPVMTLLTGRLNRHRLMMLIMILFIIGNLLAASAPTFGVLLAGRVVAALAHGIfMTVASVIAADVV 126
Cdd:cd17389 67 GLIGSLFSLLQFLSSPITGAASDVYGRKPVLLLTMIGLAISYALWAVSRSFTIFLLSRIVGGISKGN-VSLSTAIVADVT 145
|
90 100 110
....*....|....*....|....*....|.
gi 489738235 127 APAKRASAIAImftgLTVATVTGVPLGTMIG 157
Cdd:cd17389 146 SPKKRSKGMAL----IGVAFSLGFIIGPMIG 172
|
|
| MFS_Amf1_MDR_like |
cd17476 |
Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole ... |
31-361 |
1.06e-03 |
|
Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole resistance protein Atr1p, and similar transporters of the Major Facilitator Superfamily; Saccharomyces cerevisiae Amf1p/Ammonium Facilitator 1/YOR378W functions as a low affinity NH4+ transporter. S. cerevisiae aminotriazole resistance protein (Atr1p) is required for controlling sensitivity to aminotriazole; it is a putative component of the machinery responsible for pumping aminotriazole (and possibly other toxic compounds) out of the cell. This subfamily also includes S. cerevisiae YMR279C, a putative boron transporter involved in boron efflux and resistance, and Kluyveromyces lactis Knq1p which is involved in oxidative stress response and iron homeostasis. Amf1p, Atr1p, and YMR279C have been classified as group 1 members of the DHA2 (Drug:H+ Antiporter family 2) family, K. lactis Knq1 as group 2. This subfamily also includes two Aspergillus terreus terrein biosynthesis cluster proteins, efflux pump TerG and TerJ which may be required for efficient secretion of terrein or other secondary metabolites produced by the terrein gene cluster. The Amf1p-like subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341029 [Multi-domain] Cd Length: 362 Bit Score: 40.71 E-value: 1.06e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489738235 31 LMPLLVSNFHINLAQAGLTVSIYAI--GIMIgapvmtLLTGRLNR---HRLMMLI-MILFIIGNLLAASAPTFGVLLAGR 104
Cdd:cd17476 20 ILPIIGDSFGTSPNQLSWLAASYSLtvGTFI------LIFGRLGDiygHKKMFVIgSFWFAIWSLIAGFSPNFIFFIICR 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489738235 105 VVAALAHGIFMTVASVIAADVVAPAKRAS-AIAIMFTGLTVATVTGVPLGTMIGQLGGWRWSFIFISMIGVIGLLADYWl 183
Cdd:cd17476 94 ALQGLGPAFLLPNAMALLGRTYPPGPRKNiVFSLFGATAPLGFALGGVFGGLFAQLAWWPWIFWFLAILAAIVAVAAIF- 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489738235 184 iprnlplpskatvrgiirvLTNPQLLFALLVTALGYGGTFVVYTYLSPLLEQQMHWSASAVVLILVVYGLMVALGNTLGG 263
Cdd:cd17476 173 -------------------WTSPSFIAVLLAVFLGWASFGIWVFYATQYFQNVRGYSPLLTSARFIPMAIGGVLAAITVG 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489738235 264 RWANARP--LIALFKMFSGLLITLLI-LSVTGYSHW-LGLLTVLLMGIFAFMNVPGLQLYIVQLAEqntPHDITMASALN 339
Cdd:cd17476 234 FLIARLPpsYIMAISMVAFLVGPILFaTMPVHQTYWaQAFPAMIVAPFGMDFSFPAATIIASNAVP---REYQGLAGSLV 310
|
330 340
....*....|....*....|..
gi 489738235 340 ISAFNVGIALGSGIGGQVTTNL 361
Cdd:cd17476 311 NTVVNYGISIGLGIAGTVETSV 332
|
|
| MFS_CitA |
cd17368 |
Citrate-proton symporter of the Major Facilitator Superfamily of transporters; Citrate-proton ... |
59-361 |
1.30e-03 |
|
Citrate-proton symporter of the Major Facilitator Superfamily of transporters; Citrate-proton symporter, also called citrate carrier protein or citrate transporter or citrate utilization protein A (CitA), is a proton symporter that functions in the uptake of citrate across the boundary membrane. It allows the utilization of citrate as a sole source of carbon and energy. In Klebsiella pneumoniae, the gene encoding this protein is called citH, instead of citA, which is the case for Escherichia coli and other organisms. CitA belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340926 [Multi-domain] Cd Length: 407 Bit Score: 40.82 E-value: 1.30e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489738235 59 IGAPVMTLLTGRLNRHRLMMLIMILFIIGNLLAASAPTFG--------VLLAGRVVAALAHGIFMTVASVIAADVVAPAK 130
Cdd:cd17368 55 IGAIVLGAYADRIGRKPAMTLTLAIMALGTLLIALAPTYAtigiaaplLVLLARLLQGFAAGGEVGGVTAYLVEAAPPGR 134
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489738235 131 RASAIAIMFTGLTVATVTGVPLGTMIG--------QLGGWRWSFIFISMIGVIGLLADYWLI--PRNLPLPSKATVRGII 200
Cdd:cd17368 135 RGFYTSWQSASQQVAIVAGALVGYLLSltltaealAEWGWRIPFFIGLLIIPLGLWLRRSLEetEAFLERKARPTRRELF 214
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489738235 201 RVLTNPQ--LLFALLVTALGYGGTFVVYTYLSPLLEQQMHWSASAVVLILVVYGLMVALGNTLGGRWANA---RPLIALF 275
Cdd:cd17368 215 ALLANNRriILLGMLLVAGSTVTFYFTTVYTPTYAKTVLGLSARDSFLVTLLAGVANFIWAPLGGALSDRigrRPVLLVI 294
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489738235 276 KMFSGLLITLLILSVTGYSHWLGLLTVLLMgiFAFMNVPGLQLYIVQLAEQNTPHDITMASALnisAFNVGIALGSGIGG 355
Cdd:cd17368 295 TLAALVTLYPVFAWLTAAPSFGRLLLVLLV--LSFFFGMYGGAMVVALVELFPVRVRSTGFSL---VYALAVAIFGGFAQ 369
|
....*.
gi 489738235 356 QVTTNL 361
Cdd:cd17368 370 FIVTWL 375
|
|
| MFS_STP |
cd17361 |
Plant Sugar transport protein subfamily of the Major Facilitator Superfamily of transporters; ... |
48-165 |
1.30e-03 |
|
Plant Sugar transport protein subfamily of the Major Facilitator Superfamily of transporters; The plant Sugar transport protein (STP) subfamily includes STP1-STP14; they are also called hexose transporters. They mediate the active uptake of hexoses such as glucose, 3-O-methylglucose, fructose, xylose, mannose, galactose, fucose, 2-deoxyglucose and arabinose, by sugar/hydrogen symport. Several STP family transporters are expressed in a tissue-specific manner, or at specific developmental stages. STP1 is the member with the highest expression level of all members and high expression is detected in photosynthetic tissues, such as leaves and stems, while roots, siliques, and flowers show lower expression levels. It plays a major role in the uptake and response of Arabidopsis seeds and seedlings to sugars. The STP subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340919 [Multi-domain] Cd Length: 390 Bit Score: 40.70 E-value: 1.30e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489738235 48 LTVSIYAIGiMIGAPVMTLLTGRLNRHRLMMLIMILFIIGNLLAASAPTFGVLLAGRVVAALAHGIFMTVASVIAADvVA 127
Cdd:cd17361 56 FTSSLYLAG-LVASLLASYVTRKWGRKPSMLIGGVLFLVGAALNAAAQNIAMLIVGRILLGFGVGFGNQAVPLYLSE-MA 133
|
90 100 110 120
....*....|....*....|....*....|....*....|...
gi 489738235 128 PAKRASAIAIMF-----TGLTVATVtgVPLGTMIGQLGGWRWS 165
Cdd:cd17361 134 PAKLRGALNIGFqlaitIGILIANL--INYGTSKIKPNGWRLS 174
|
|
| PRK10473 |
PRK10473 |
MdtL family multidrug efflux MFS transporter; |
44-307 |
1.44e-03 |
|
MdtL family multidrug efflux MFS transporter;
Pssm-ID: 182486 [Multi-domain] Cd Length: 392 Bit Score: 40.39 E-value: 1.44e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489738235 44 AQAGLTVSIYAIGIMIGAPVMTLLTGRLNRHRLMMLIMILFIIGNLLAASAPTFGVLLAGRVVAALAHGIFMTVASVIAA 123
Cdd:PRK10473 38 AQLHIAFSVYLAGMAAAMLFAGKIADRSGRKPVAIPGAALFIIASLLCSLAETSSLFLAGRFLQGIGAGCCYVVAFAILR 117
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489738235 124 DVVAPAKRASAIAiMFTGLT-VATVTGVPLGTMIgqLGGWRWSFIFISMIGV---IGLLADYWL-------IPRNLPLPS 192
Cdd:PRK10473 118 DTLDDRRRAKVLS-LLNGITcIIPVLAPVLGHLI--MLKFPWQSLFYTMAAMgilVLLLSLFILketrparAPAASSKPR 194
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489738235 193 KATvrgiiRVLTNPQLLFALLVTALGYgGTFVVYTYLSP-LLEQQMHWSA---SAVVLILVVYGLMVALGNTLGGRWANA 268
Cdd:PRK10473 195 ENS-----ESLLNRFFLSRLVITTLSV-TVILTFVNTSPvLLMEQMGFSRgeyAIIMALTAGVSMTVSFSTPFALGIFKP 268
|
250 260 270
....*....|....*....|....*....|....*....
gi 489738235 269 RPLIALFKmfsGLLITLLILSVTGYSHWLGLLTVLLMGI 307
Cdd:PRK10473 269 RTLMLTSQ---VLFLAAGITLALSPSHAVSLFGITLICA 304
|
|
| MFS_MCT_SLC16 |
cd17352 |
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; ... |
5-178 |
1.62e-03 |
|
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; The animal Monocarboxylate transporter (MCT) family is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCT1-4 are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT8 and MCT10 are transporters which stimulate the cellular uptake of thyroid hormones such as thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). MCT10 also functions as a sodium-independent transporter that mediates the uptake or efflux of aromatic acids. Many members are orphan transporters whose substrates are yet to be determined. The MCT family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340910 [Multi-domain] Cd Length: 361 Bit Score: 40.23 E-value: 1.62e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489738235 5 FNPSWTLFALAISAFAIGstEFISVGLMPLLVSNFHINLAQAGLTVSIYAIGIMIGAPVMTLLTGRLNRHRLMMLIMILF 84
Cdd:cd17352 181 KDPTFVLLALGVSFAMLG--FFVPFVYLPSYAKSLGIDESDAAFLLSIIGISDIVGRILLGLLADKPRIGRLYLYIFTLL 258
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489738235 85 IIGNLLAAS--APTFGVLLAGRVVAALAHGIFMTVASVIAADVVAPAKRASAIAIMFTGLTVATVTGVPL-GTMIGQLGG 161
Cdd:cd17352 259 ILGLSLLAFplATTYVGLIVFSVLFGFCSGSYSSLTPVILADLVGLEKLSNAYGLVLLFQGLAALVGPPIaGLLRDYTGD 338
|
170
....*....|....*..
gi 489738235 162 WRWSFIFISMIGVIGLL 178
Cdd:cd17352 339 YDAAFYFCGACLLLSGV 355
|
|
| MFS_SLCO1C_OATP1C |
cd17459 |
Solute carrier organic anion transporter 1C subfamily of the Major Facilitator Superfamily of ... |
159-263 |
1.74e-03 |
|
Solute carrier organic anion transporter 1C subfamily of the Major Facilitator Superfamily of transporters; The Solute carrier organic anion transporter 1C (SLCO1C), also called Organic anion-transporting polypeptide 1C (OATP1C), subfamily contains one mammalian member, OATP1C1 (encoded by SLCO1C1), which is also called thyroxine transporter. It mediates the high affinity transport of the thyroid hormones, T4 (3,5,3',5'tetraiodo-L-thyronine or thyroxine), rT3 (3,3'5'-triiodo-L-thyronine), and T3 (3,5,3'tri-iodo-L-thyronine or triiodothyronine), as well as organic anions such as 17-beta-glucuronosyl estradiol, estrone-3-sulfate, and sulfobromophthalein (BSP), which are transported with much lower efficiency. The SLCO1C/OATP1C subfamily belongs to the Solute carrier organic anion transporter [SLCO, also called organic anion transporting polypeptides (OATPs) or Solute carrier family 21] family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341017 [Multi-domain] Cd Length: 498 Bit Score: 40.52 E-value: 1.74e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489738235 159 LGGWrWSFIFISmiGVIGLLA--DYWLIPRNLP---LPSkatvrgIIRVLTNPQLLFALLVTALGYGGTFVVYTYLSPLL 233
Cdd:cd17459 229 VGAW-WLGYLIA--GVITLLSavPFWFLPKSLPkdfLPS------LKNLLGNPVYFLYLCTSILQFNSLIGMVTYKPKYI 299
|
90 100 110
....*....|....*....|....*....|.
gi 489738235 234 EQQMHWSASAVVLILVVYGL-MVALGNTLGG 263
Cdd:cd17459 300 EQQYGQSASKANFLIGLINIpAVAIGIFSGG 330
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
212-377 |
2.45e-03 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 39.71 E-value: 2.45e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489738235 212 LLVTALGYGGTFVVYTYLSPLLEQQMHWSASAVVLILVVYGLMVALGNTLGGRWANARPLIALFKMFSGLLITLLILSVT 291
Cdd:pfam07690 2 FLAAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLF 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489738235 292 GYSHWLGLLTVLLMGIFAFMNVPGLQLYIVQLAEqntPHDITMASALNISAFNVGIALGSGIGGQVTTNLGLGWTPIFGA 371
Cdd:pfam07690 82 ASSLWLLLVLRVLQGLGAGALFPAALALIADWFP---PEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILA 158
|
....*.
gi 489738235 372 IMVAVS 377
Cdd:pfam07690 159 ILSLLA 164
|
|
| PRK10504 |
PRK10504 |
putative transporter; Provisional |
53-185 |
2.98e-03 |
|
putative transporter; Provisional
Pssm-ID: 182502 [Multi-domain] Cd Length: 471 Bit Score: 39.71 E-value: 2.98e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489738235 53 YAIGIMIGAPVMTLLTGRLNRHRLMMLIMILFIIGNLLAASAPTFGVLLAGRVVAALAHGIFMTVASVIAADVVAPAKRA 132
Cdd:PRK10504 54 YVLTVAVMLPASGWLADRVGVRNIFFTAIVLFTLGSLFCALSGTLNELLLARVLQGVGGAMMVPVGRLTVMKIVPREQYM 133
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|...
gi 489738235 133 SAIAIMFTGLTVATVTGVPLGTMIGQLGGWRWSFIFISMIGVIGLLADYWLIP 185
Cdd:PRK10504 134 AAMTFVTLPGQVGPLLGPALGGLLVEYASWHWIFLINIPVGIIGAIATLMLMP 186
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
70-377 |
3.35e-03 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 39.45 E-value: 3.35e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489738235 70 RLNRHRLMMLI-MILFIIGNLLAASAPTFGVLLAGRVVAALAHGIFMTVASVIAADVVAPAKRASAIAIMFTGLTVATVT 148
Cdd:cd17370 60 RTGKRKPLVILgYGLSALAKPLLALAGSWQLVLLLRILERLGKGIRTPPRDALLADATPPSGRGKAFGLHRALDTLGAVL 139
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489738235 149 GVPLGT--MIGQLGGWRWSFIFISMIGVIGLLADYWLIPRNLPLPSKATVRGIIRVLTNPQ-----LLFALLVTALGYGG 221
Cdd:cd17370 140 GPLLAAllLYLLGGNYRTIFLLAAIPALLALLILLFVVKEYPRPPKLRKKSKKTSLKKLPKafwlyLLAVALFALGNFSF 219
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489738235 222 TFVVYTYlsplleQQMHWSASAVVLILVVYGLMVALGNTLGGRWA--NARPLIALFKMFSGLLITLLILSvtGYSHWLGL 299
Cdd:cd17370 220 AFLILRA------QELGLSAALIPLLYALFNLVYALAAYPAGRLSdrIGRKKLLILGYLSLALAYLGFAL--GSSLWLLL 291
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489738235 300 LTVLLMGIFAFMNVPGLQLYIVQLAEQNTphditMASALNISAFNVGIA--LGSGIGGQVTTNLGLGWTPIFGAIMVAVS 377
Cdd:cd17370 292 LGFILWGLYMGAQESIERAAVADLVPAEL-----RGTAYGLFNTVVGIGwlLASLIAGYLWDLISPSAAFLFSAVLALIA 366
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
8-178 |
3.44e-03 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 39.10 E-value: 3.44e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489738235 8 SWTLFALAISAFAIGsteFISVGLMPLLVSNFHINLAQAGLTVSIYAI-GIMIGAPVMTLLTGRLNRHRLMMLIMILFII 86
Cdd:cd17330 177 RRLLLVYFLIALAFA---GLESVFSLFLKDRFGFSPSQIGLLLALVGIaGILAQLLLIPRLAKRLGERKLLRLGLLLAII 253
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489738235 87 GNLLAASAPTFGVLLAGRVVAALAHGIFMTVASVIAADVVAPAKRASAIAIMFTGLTVATVTGVPLGTMIGQLGGWRWSF 166
Cdd:cd17330 254 GLLLLPFASSVPLLVLAAAILAFGTGIVFPALSALLSKSVPSKEQGKAQGIIQSLQSLARIIGPLLAGPLYSFLGPGVPF 333
|
170
....*....|..
gi 489738235 167 IFISMIGVIGLL 178
Cdd:cd17330 334 LLAAGLLLIALF 345
|
|
| MFS_FEN2_like |
cd17327 |
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; ... |
40-194 |
3.49e-03 |
|
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; This family is composed of Saccharomyces cerevisiae pantothenate transporter FEN2 (or fenpropimorph resistance protein 2) and similar proteins from fungi and bacteria including fungal vitamin H transporter, allantoate permease, and high-affinity nicotinic acid transporter, as well as Pseudomonas putida phthalate transporter and nicotinate degradation protein T (nicT). These proteins are involved in the uptake into the cell of specific substrates such as pathothenate, biotin, allantoate, and nicotinic acid, among others. The FEN2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340885 [Multi-domain] Cd Length: 406 Bit Score: 39.15 E-value: 3.49e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489738235 40 HINLAQAGLTVSIYAIGIMIGAPVMTLLTGRLNRHRLMMLIMILFIIGNLLAASAPTFGVLLAGRVVAALAHGIFMTVAS 119
Cdd:cd17327 37 KLVGNQYNWGNTVFYVGYIIFELPGNLLLQRFPPSKWLSVFIVLWGLLTLLTAAVKNFGGLIALRFFLGLFESGVFPGFI 116
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489738235 120 VIAADVVAPAKRASAIAIMFTGLTVATVTGVPLGTMIGQ------LGGWRWSFIFISMIGVIGLLADYWLIPRNlplPSK 193
Cdd:cd17327 117 LYLGMWYKREEQAKRIAFFYAAAGLGSIFGGLLAYGVFKilgvggLAGWRWLFIIEGLITIIIGLVIFFWLPDN---PSK 193
|
.
gi 489738235 194 A 194
Cdd:cd17327 194 A 194
|
|
| MFS_OPA_SLC37 |
cd17312 |
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ... |
32-184 |
3.72e-03 |
|
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340870 [Multi-domain] Cd Length: 364 Bit Score: 39.18 E-value: 3.72e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489738235 32 MPLLVSNFHINLAQAGLTVSIYAIGIMIGAPVMTLLTGRLNRHRLMMLIMILFIIGNLLAASAPTFGVLLAGRVVAALAH 111
Cdd:cd17312 26 KPPIVEEIGLSKDDLGIIGSAFLIAYAVGKFISGFLSDRSNIRRFMSAGLLLSALANIFMGFSTSLWFFAVLWGLNGLFQ 105
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 489738235 112 GIFMTVASVIAADVVAPAKRASAIAIMFTGLTVATVTGVPLGTMIGQLGGWRWSFIFISMIGVIGLLADYWLI 184
Cdd:cd17312 106 SMGWPPCVKLLGNWFSKKERGTVYGIWSTSHNFGGILAPILAASLASYYGWRAAFLVPGIVGLVVAIILFFFL 178
|
|
| MFS_FEN2_like |
cd17327 |
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; ... |
9-147 |
7.95e-03 |
|
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; This family is composed of Saccharomyces cerevisiae pantothenate transporter FEN2 (or fenpropimorph resistance protein 2) and similar proteins from fungi and bacteria including fungal vitamin H transporter, allantoate permease, and high-affinity nicotinic acid transporter, as well as Pseudomonas putida phthalate transporter and nicotinate degradation protein T (nicT). These proteins are involved in the uptake into the cell of specific substrates such as pathothenate, biotin, allantoate, and nicotinic acid, among others. The FEN2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340885 [Multi-domain] Cd Length: 406 Bit Score: 38.00 E-value: 7.95e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489738235 9 WTLFALAISAFAIGSTEFISVGLMPLLVSNFHINLAQAGL-TVSIYAIGiMIGAPVMTLLTGRLNRHRLMMLIMILF-II 86
Cdd:cd17327 233 PRTWLLFLFFFCSQITNNGISNFLPLILKSLGFYSLQTNLlSVPIGALG-AVSLLIAALLSDRFKKRGLFAIFACVLaLV 311
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 489738235 87 GNLLAASAPT-----FGVLLAGRVVAAlAHGIFMTVASVIAADVVapaKRASAIAIMFTGLTVATV 147
Cdd:cd17327 312 GSIILLAAPNppgayFAAYILGGGSYA-GFPILLSWISSNCAGYT---KRATVLAIMLIFYNVGNI 373
|
|
| MFS_GLUT10_Class3 |
cd17436 |
Glucose transporter type 10 (GLUT10), a Class 3 GLUT, of the Major Facilitator Superfamily of ... |
30-254 |
9.66e-03 |
|
Glucose transporter type 10 (GLUT10), a Class 3 GLUT, of the Major Facilitator Superfamily of transporters; Glucose transporter type 10 (GLUT10) is also called Solute carrier family 2, facilitated glucose transporter member 10 (SLC2A10). It is classified as a Class 3 GLUT and is a facilitative glucose transporter that exhibits a wide tissue distribution. It is expressed in pancreas, placenta, heart, lung, liver, brain, fat, muscle, and kidney. GLUT10 facilitates the transport of dehydroascorbic acid (DHA), the oxidized form of vitamin C, into mitochondria, and also increases cellular uptake of DHA, which in turn protects cells against oxidative stress. Loss-of-function mutations in SLC2A10 cause arterial tortuosity syndrome (ATS), an autosomal recessive connective tissue disorder characterized by twisting and lengthening of the major arteries, hypermobility of the joints, and laxity of skin. The GLUT10 subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340994 [Multi-domain] Cd Length: 376 Bit Score: 37.86 E-value: 9.66e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489738235 30 GLMPLLVSNFHINLAQAGLTVSIYAIGIMIGAPVMTLLTGRLNRHRLMMLIMILFIIGNLLAASAPTFGVLLAGRVVAAL 109
Cdd:cd17436 22 GALLQLQTDFSLSCFEQEALVSALLIGALLASLIGGFLIDRHGRRTSILGSNLVLLAGSLILTLAGSFFWLVIGRAVVGF 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489738235 110 AHGIFMTVASVIAADVVAPAKRASAIAIMFTGLTVATVTGVPLGTMI-GQLGGWRWSFIFISMIGVIGLLADywliprnL 188
Cdd:cd17436 102 AISVSSMACCIYVSEMVTPHQRGLLVSLYEAGITVGILISYALNYFFsNVLTGWRYMFGLAIIPAAIQFASI-------L 174
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 489738235 189 PLPSKATVRGIIRVLTNPQLLFALLVTALGYGGTFVVYTYLSPLLEQQMHWSASAVVLILVVYGLM 254
Cdd:cd17436 175 LLPKKPEVLNIKDNMRRRTLVGLGLVLFQQFTGQPNVLCYASTIFRSVGFQSNSSAVLASVGLGVV 240
|
|
| MFS_ARN_like |
cd17322 |
Yeast ARN family of Siderophore iron transporters and similar proteins of the Major ... |
201-360 |
9.91e-03 |
|
Yeast ARN family of Siderophore iron transporters and similar proteins of the Major Facilitator Superfamily; The ARN family of siderophore iron transporters includes ARN1 (or ferrichrome permease), ARN2 (or triacetylfusarinine C transporter 1 or TAF1), ARN3 (or siderophore iron transporter 1 or SIT1 or ferrioxamine B permease) and ARN4 (or Enterobactin permease or ENB1). They specifically recognize siderophore-iron chelates are expressed under conditions of iron deprivation. They facilitate the uptake of both hydroxamate- and catecholate-type siderophores. This group also includes glutathione exchanger 1 (Gex1p) and Gex2p, which are proton/glutathione antiporters that import glutathione from the vacuole and exports it through the plasma membrane. The ARN family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340880 [Multi-domain] Cd Length: 514 Bit Score: 38.06 E-value: 9.91e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489738235 201 RVLTNPQLLFALLVTALGYGGTFVVYTYLSPLLEQQMHWSASAVVLILVVYGLMVALGNTLGGRWANARPLIALFKMFSG 280
Cdd:cd17322 280 RLLKDRTILAACLIDFFYFFSYYIFSDYLYTVLQVAVGESITSATRITNLYSFVSTVAGIFVGFLIRKTRRYKVLVIIGV 359
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489738235 281 LL----ITLLILSVTGYSHWLGLLTVL-LMGIFAfmnvpGLQLYIVQLAEQ-NTPH-DITMASALNISAFNVGIALGSGI 353
Cdd:cd17322 360 PLyivgMGLLIRYRGGSGSHGGIIGALiLIGIGG-----GLFTYPVQVSVQaSVSHqEMAVVTALLLTVYSIGGAVGAAI 434
|
....*..
gi 489738235 354 GGQVTTN 360
Cdd:cd17322 435 SGAIWTQ 441
|
|
| |
