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Conserved domains on  [gi|489736721|ref|WP_003640816|]
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MULTISPECIES: exosortase family protein XrtG [Lactobacillaceae]

Protein Classification

exosort_Gpos family protein( domain architecture ID 10022132)

exosort_Gpos family protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
exosort_Gpos TIGR03110
exosortase family protein XrtG; Members of this protein family are found in a modest number of ...
 3-189 6.10e-72

exosortase family protein XrtG; Members of this protein family are found in a modest number of non-pathogenic Gram-positive bacteria, including three species of Lactococcus and three paralogs in Clostridium acetobutylicum. This protein appears related to the conserved core region of a family of proposed transpeptidases, exosortase (previously EpsH), thought to act on PEP-CTERM proteins. Members of the seed alignment include all exosortase proposed active site residues. However, in contrast to canonical exosortase (TIGR02602) and archaeal (TIGR03762), and cyanobacterial (TIGR03763) variants, this family has not yet been matched to a cognate PEP-CTERM-like sorting signal. This protein is assigned the gene symbol XrtG (eXosoRTase family protein of Gram-positives).


:

Pssm-ID: 188282  Cd Length: 187  Bit Score: 216.09  E-value: 6.10e-72
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489736721    3 VKILLGIVIWLYGLSVLKRARLSAFYFIVGSAGLFFILTAISRPYWVWFFTHAVIHGVALFSDITGWCSIMFKMGLVYII 82
Cdd:TIGR03110   1 VLICLLIIAWIYLLSVLKRAKLDFFYFIVGSVGLFFILTFFFRNYLVWFLSRCVSTVLGLIGDLTGYFSSFIDNNLISIE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489736721   83 NSGNPVIMSIDYECSGIIETCAFISLVAFYPAYQRREKVFYGVFGLLYIYLINVLRLSVVIVIVHFGGGQTFFLAHSVIG 162
Cdd:TIGR03110  81 TKGGLISIFIDYECSGVIETLAFTSLLWFYPFYQRLEKIFYTIFGDLWIFLANILRISLIIVIVKYFGVSSFYIAHTVLG 160

                         170       180
                  ....*....|....*....|....*..
gi 489736721  163 RLLFYVLVIVLYYNVFTYSQLARGLYQ 189
Cdd:TIGR03110 161 RIIFYVLVIILYYNVFTKSQLKRQNVG 187
 
Name Accession Description Interval E-value
exosort_Gpos TIGR03110
exosortase family protein XrtG; Members of this protein family are found in a modest number of ...
 3-189 6.10e-72

exosortase family protein XrtG; Members of this protein family are found in a modest number of non-pathogenic Gram-positive bacteria, including three species of Lactococcus and three paralogs in Clostridium acetobutylicum. This protein appears related to the conserved core region of a family of proposed transpeptidases, exosortase (previously EpsH), thought to act on PEP-CTERM proteins. Members of the seed alignment include all exosortase proposed active site residues. However, in contrast to canonical exosortase (TIGR02602) and archaeal (TIGR03762), and cyanobacterial (TIGR03763) variants, this family has not yet been matched to a cognate PEP-CTERM-like sorting signal. This protein is assigned the gene symbol XrtG (eXosoRTase family protein of Gram-positives).


Pssm-ID: 188282  Cd Length: 187  Bit Score: 216.09  E-value: 6.10e-72
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489736721    3 VKILLGIVIWLYGLSVLKRARLSAFYFIVGSAGLFFILTAISRPYWVWFFTHAVIHGVALFSDITGWCSIMFKMGLVYII 82
Cdd:TIGR03110   1 VLICLLIIAWIYLLSVLKRAKLDFFYFIVGSVGLFFILTFFFRNYLVWFLSRCVSTVLGLIGDLTGYFSSFIDNNLISIE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489736721   83 NSGNPVIMSIDYECSGIIETCAFISLVAFYPAYQRREKVFYGVFGLLYIYLINVLRLSVVIVIVHFGGGQTFFLAHSVIG 162
Cdd:TIGR03110  81 TKGGLISIFIDYECSGVIETLAFTSLLWFYPFYQRLEKIFYTIFGDLWIFLANILRISLIIVIVKYFGVSSFYIAHTVLG 160

                         170       180
                  ....*....|....*....|....*..
gi 489736721  163 RLLFYVLVIVLYYNVFTYSQLARGLYQ 189
Cdd:TIGR03110 161 RIIFYVLVIILYYNVFTKSQLKRQNVG 187
 
Name Accession Description Interval E-value
exosort_Gpos TIGR03110
exosortase family protein XrtG; Members of this protein family are found in a modest number of ...
 3-189 6.10e-72

exosortase family protein XrtG; Members of this protein family are found in a modest number of non-pathogenic Gram-positive bacteria, including three species of Lactococcus and three paralogs in Clostridium acetobutylicum. This protein appears related to the conserved core region of a family of proposed transpeptidases, exosortase (previously EpsH), thought to act on PEP-CTERM proteins. Members of the seed alignment include all exosortase proposed active site residues. However, in contrast to canonical exosortase (TIGR02602) and archaeal (TIGR03762), and cyanobacterial (TIGR03763) variants, this family has not yet been matched to a cognate PEP-CTERM-like sorting signal. This protein is assigned the gene symbol XrtG (eXosoRTase family protein of Gram-positives).


Pssm-ID: 188282  Cd Length: 187  Bit Score: 216.09  E-value: 6.10e-72
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489736721    3 VKILLGIVIWLYGLSVLKRARLSAFYFIVGSAGLFFILTAISRPYWVWFFTHAVIHGVALFSDITGWCSIMFKMGLVYII 82
Cdd:TIGR03110   1 VLICLLIIAWIYLLSVLKRAKLDFFYFIVGSVGLFFILTFFFRNYLVWFLSRCVSTVLGLIGDLTGYFSSFIDNNLISIE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489736721   83 NSGNPVIMSIDYECSGIIETCAFISLVAFYPAYQRREKVFYGVFGLLYIYLINVLRLSVVIVIVHFGGGQTFFLAHSVIG 162
Cdd:TIGR03110  81 TKGGLISIFIDYECSGVIETLAFTSLLWFYPFYQRLEKIFYTIFGDLWIFLANILRISLIIVIVKYFGVSSFYIAHTVLG 160

                         170       180
                  ....*....|....*....|....*..
gi 489736721  163 RLLFYVLVIVLYYNVFTYSQLARGLYQ 189
Cdd:TIGR03110 161 RIIFYVLVIILYYNVFTKSQLKRQNVG 187
exo_archaeo TIGR04178
exosortase/archaeosortase family protein; This model represents the most conserved region of ...
 90-175 2.93e-10

exosortase/archaeosortase family protein; This model represents the most conserved region of the multitransmembrane protein family of exosortases and archaeosortases. The region includes nearly invariant motifs at the ends of three predicted transmembrane helices on the extracytoplasmic face: a Cys (often Cys-Xaa-Gly), Asn-Xaa-Xaa-Arg, and His. This model is much broader than the bacterial exosortase model (TIGR02602), and has in intended scope similar to (or broader than) pfam09721.


Pssm-ID: 275031 [Multi-domain]  Cd Length: 97  Bit Score: 54.92  E-value: 2.93e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489736721   90 MSIDYECSGIIETCAFISLVAFYPAYQR---REKVFYGVFGLLYIYLINVLRLSVVIVIVHFGGGQTFFLAHSVIGRLLF 166
Cdd:TIGR04178   1 VEVAEACSGLRSLILLLALGLLFAYLFPrslRRKLLLLLLGVPIIYLANILRIVLLILLGYYFGPEAFEFAHDILGWLLF 80


                  ....*....
gi 489736721  167 YVLVIVLYY 175
Cdd:TIGR04178  81 LLVALLLLL 89
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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