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Conserved domains on  [gi|489610262|ref|WP_003514703|]
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sensor histidine kinase [Acetivibrio thermocellus]

Protein Classification

sensor histidine kinase( domain architecture ID 20493667)

sensor histidine kinase, part of a two-component regulatory system, functions as a protein kinase that phosphorylates a target protein in response to various signals

CATH:  3.30.565.10
EC:  2.7.13.3
Gene Ontology:  GO:0005524|GO:0004673|GO:0007165|GO:0000155
PubMed:  10637609|10339418
SCOP:  4001957

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
COG4191 COG4191
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal ...
 290-609 4.83e-37

Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms];


:

Pssm-ID: 443345 [Multi-domain]  Cd Length: 361  Bit Score: 141.47  E-value: 4.83e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489610262 290 LLAFQTIDSINGIELGWTVFGMTPVDIITSGIESTQDILYEIGLICVIAGFVISLLITRLYNAHLEKRYERKHSIIMERE 369
Cdd:COG4191   58 LLLLLELLLLLLALLGGLLRLLLLLGLLLLLLLEALLLLLLAALDAEENAELEELERDITELERAEEELRELQEQLVQSE 137

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489610262 370 RLASLGQLMGGIAQSFKAPIMSISDGLDELNSLVDEYEKsienenvsdetrheiASRMRECLDKIKPHCSYISDEISAVK 449
Cdd:COG4191  138 KLAALGELAAGIAHEINNPLAAILGNAELLRRRLEDEPD---------------PEELREALERILEGAERAAEIVRSLR 202

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489610262 450 gqavNFNDSTDG---IFTVDELIKNVKLLMSHEIKFWNCEMNVEL-----KVSGDtsiRGEINnmtQVMNNIITNAIEAY 521
Cdd:COG4191  203 ----AFSRRDEEerePVDLNELIDEALELLRPRLKARGIEVELDLppdlpPVLGD---PGQLE---QVLLNLLINAIDAM 272

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489610262 522 -NGKGGKIDLIFSKKGHNLEITVRDYGCGIPESVKSKLFKEMVTTK-GSKGTGIGVYMAYSTIKgKFGGTMTIDSKEGKG 599
Cdd:COG4191  273 eEGEGGRITISTRREGDYVVISVRDNGPGIPPEVLERIFEPFFTTKpVGKGTGLGLSISYGIVE-KHGGRIEVESEPGGG 351

                        330
                 ....*....|
gi 489610262 600 TSVNITIPLK 609
Cdd:COG4191  352 TTFTITLPLA 361
dCache_1 pfam02743
Cache domain; Double cache domain 1 covers the last three strands from the membrane distal ...
 54-311 1.13e-23

Cache domain; Double cache domain 1 covers the last three strands from the membrane distal PAS-like domain, the first two strands of the membrane proximal domain, and the connecting elements between the two domains. This domain when present in chemoreceptors recognize several signals such as proteinogenic amino acids, GABA, Histamine and polyamines, decanoic acid, Autoinducer-2, purine derivatives, quaternary amines, citrate and taurine, among others. When associated with histidine kinases, it recognizes C3/C4-dicarboxylic acids, Spermine, guanosine and Autoinducer-2 (Mantilla et al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1 https://doi.org/10.1093/femsre/fuab043).


:

Pssm-ID: 460673 [Multi-domain]  Cd Length: 237  Bit Score: 100.10  E-value: 1.13e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489610262   54 DAMIRHAGADNLELVKQITKNIETVMTGFDDISNEILTNENFDRLVKMHVTLDDEHkkaanrrsiesiLNGYTNTRTDIA 133
Cdd:pfam02743   1 KAIKEQAEEQLLSLAKQLAENIESYLDSLEEILELLASNPDLQDLLSAPAEEELAK------------LESLLRSNPGIS 68

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489610262  134 DIAVVTNTGEYITSGETRPLVTDNALS---YYvvKRFKQSGRDSLWLDTYQTEVASTGthtgnQLVISNIKSIKGENNEE 210
Cdd:pfam02743  69 SIYLVDADGRVLASSDESPSYPGLDVSerpWY--KEALKGGGGIIWVFSSPYPSSESG-----EPVLTIARPIYDDDGEV 141

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489610262  211 IGMLILNVKESYIYSLISEIKLPDEGQLYIVGKDGNYVMNPFNRLQNGKVDYVKYELYIEEILKKKNGTFIKKIDGRDYL 290
Cdd:pfam02743 142 IGVLVADLDLDTLQELLSQIKLGEGGYVFIVDSDGRILAHPLGKNLRSLLAPFLGKSLADALPGSGITEIAVDLDGEDYL 221

                         250       260
                  ....*....|....*....|.
gi 489610262  291 LAFQTIDSingieLGWTVFGM 311
Cdd:pfam02743 222 VAYAPIPG-----TGWTLVVV 237
 
Name Accession Description Interval E-value
COG4191 COG4191
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal ...
 290-609 4.83e-37

Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms];


Pssm-ID: 443345 [Multi-domain]  Cd Length: 361  Bit Score: 141.47  E-value: 4.83e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489610262 290 LLAFQTIDSINGIELGWTVFGMTPVDIITSGIESTQDILYEIGLICVIAGFVISLLITRLYNAHLEKRYERKHSIIMERE 369
Cdd:COG4191   58 LLLLLELLLLLLALLGGLLRLLLLLGLLLLLLLEALLLLLLAALDAEENAELEELERDITELERAEEELRELQEQLVQSE 137

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489610262 370 RLASLGQLMGGIAQSFKAPIMSISDGLDELNSLVDEYEKsienenvsdetrheiASRMRECLDKIKPHCSYISDEISAVK 449
Cdd:COG4191  138 KLAALGELAAGIAHEINNPLAAILGNAELLRRRLEDEPD---------------PEELREALERILEGAERAAEIVRSLR 202

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489610262 450 gqavNFNDSTDG---IFTVDELIKNVKLLMSHEIKFWNCEMNVEL-----KVSGDtsiRGEINnmtQVMNNIITNAIEAY 521
Cdd:COG4191  203 ----AFSRRDEEerePVDLNELIDEALELLRPRLKARGIEVELDLppdlpPVLGD---PGQLE---QVLLNLLINAIDAM 272

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489610262 522 -NGKGGKIDLIFSKKGHNLEITVRDYGCGIPESVKSKLFKEMVTTK-GSKGTGIGVYMAYSTIKgKFGGTMTIDSKEGKG 599
Cdd:COG4191  273 eEGEGGRITISTRREGDYVVISVRDNGPGIPPEVLERIFEPFFTTKpVGKGTGLGLSISYGIVE-KHGGRIEVESEPGGG 351

                        330
                 ....*....|
gi 489610262 600 TSVNITIPLK 609
Cdd:COG4191  352 TTFTITLPLA 361
dCache_1 pfam02743
Cache domain; Double cache domain 1 covers the last three strands from the membrane distal ...
 54-311 1.13e-23

Cache domain; Double cache domain 1 covers the last three strands from the membrane distal PAS-like domain, the first two strands of the membrane proximal domain, and the connecting elements between the two domains. This domain when present in chemoreceptors recognize several signals such as proteinogenic amino acids, GABA, Histamine and polyamines, decanoic acid, Autoinducer-2, purine derivatives, quaternary amines, citrate and taurine, among others. When associated with histidine kinases, it recognizes C3/C4-dicarboxylic acids, Spermine, guanosine and Autoinducer-2 (Mantilla et al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1 https://doi.org/10.1093/femsre/fuab043).


Pssm-ID: 460673 [Multi-domain]  Cd Length: 237  Bit Score: 100.10  E-value: 1.13e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489610262   54 DAMIRHAGADNLELVKQITKNIETVMTGFDDISNEILTNENFDRLVKMHVTLDDEHkkaanrrsiesiLNGYTNTRTDIA 133
Cdd:pfam02743   1 KAIKEQAEEQLLSLAKQLAENIESYLDSLEEILELLASNPDLQDLLSAPAEEELAK------------LESLLRSNPGIS 68

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489610262  134 DIAVVTNTGEYITSGETRPLVTDNALS---YYvvKRFKQSGRDSLWLDTYQTEVASTGthtgnQLVISNIKSIKGENNEE 210
Cdd:pfam02743  69 SIYLVDADGRVLASSDESPSYPGLDVSerpWY--KEALKGGGGIIWVFSSPYPSSESG-----EPVLTIARPIYDDDGEV 141

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489610262  211 IGMLILNVKESYIYSLISEIKLPDEGQLYIVGKDGNYVMNPFNRLQNGKVDYVKYELYIEEILKKKNGTFIKKIDGRDYL 290
Cdd:pfam02743 142 IGVLVADLDLDTLQELLSQIKLGEGGYVFIVDSDGRILAHPLGKNLRSLLAPFLGKSLADALPGSGITEIAVDLDGEDYL 221

                         250       260
                  ....*....|....*....|.
gi 489610262  291 LAFQTIDSingieLGWTVFGM 311
Cdd:pfam02743 222 VAYAPIPG-----TGWTLVVV 237
HATPase_c smart00387
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
 506-609 5.49e-23

Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.


Pssm-ID: 214643 [Multi-domain]  Cd Length: 111  Bit Score: 93.87  E-value: 5.49e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489610262   506 MTQVMNNIITNAIEaYNGKGGKIDLIFSKKGHNLEITVRDYGCGIPESVKSKLFKEMVTTKGS----KGTGIGVYMAYST 581
Cdd:smart00387   6 LRQVLSNLLDNAIK-YTPEGGRITVTLERDGDHVEITVEDNGPGIPPEDLEKIFEPFFRTDKRsrkiGGTGLGLSIVKKL 84

                           90       100
                   ....*....|....*....|....*...
gi 489610262   582 IKgKFGGTMTIDSKEGKGTSVNITIPLK 609
Cdd:smart00387  85 VE-LHGGEISVESEPGGGTTFTITLPLE 111
PRK11360 PRK11360
two-component system sensor histidine kinase AtoS;
356-612 4.77e-20

two-component system sensor histidine kinase AtoS;


Pssm-ID: 236901 [Multi-domain]  Cd Length: 607  Bit Score: 94.26  E-value: 4.77e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489610262 356 KRYERKhsiIMERERLASLGQLMGGIAQSFKAPIMSISDgldelnslvdeYEKSIENENVSDETRHEIASRMREC--LDK 433
Cdd:PRK11360 375 KRLQRR---VARQERLAALGELVAGVAHEIRNPLTAIRG-----------YVQIWRQQTSDPPSQEYLSVVLREVdrLNK 440

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489610262 434 I--------KPhcsyisdeiSAVKGQAVNFNdstdgiftvdELIKNVKLLMSHEIKFWNCemNVELKVSGD---TSIRGE 502
Cdd:PRK11360 441 VidqllefsRP---------RESQWQPVSLN----------ALVEEVLQLFQTAGVQARV--DFETELDNElppIWADPE 499

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489610262 503 InnMTQVMNNIITNAIEAYNGkGGKIDL-IFSKKGHNLEITVRDYGCGIPESVKSKLFKEMVTTKgSKGTGIGVYMAYST 581
Cdd:PRK11360 500 L--LKQVLLNILINAVQAISA-RGKIRIrTWQYSDGQVAVSIEDNGCGIDPELLKKIFDPFFTTK-AKGTGLGLALSQRI 575

                        250       260       270
                 ....*....|....*....|....*....|.
gi 489610262 582 IKGkFGGTMTIDSKEGKGTSVNITIPLKDKD 612
Cdd:PRK11360 576 INA-HGGDIEVESEPGVGTTFTLYLPINPQG 605
HATPase_c pfam02518
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the ...
 508-609 2.24e-18

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.


Pssm-ID: 460579 [Multi-domain]  Cd Length: 109  Bit Score: 80.88  E-value: 2.24e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489610262  508 QVMNNIITNAIEaYNGKGGKIDLIFSKKGHnLEITVRDYGCGIPESVKSKLFKEMVTTKGSK--GTGIGVYMAYSTIKgK 585
Cdd:pfam02518   8 QVLSNLLDNALK-HAAKAGEITVTLSEGGE-LTLTVEDNGIGIPPEDLPRIFEPFSTADKRGggGTGLGLSIVRKLVE-L 84

                          90       100
                  ....*....|....*....|....
gi 489610262  586 FGGTMTIDSKEGKGTSVNITIPLK 609
Cdd:pfam02518  85 LGGTITVESEPGGGTTVTLTLPLA 108
HATPase_AtoS-like cd16943
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 500-608 2.62e-16

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 AtoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Escherichia coli AtoS, an HK of the AtoS-AtoC TCS. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have accessory domains such as HAMP or PAS sensor domains or CBS-pair domains.


Pssm-ID: 340419 [Multi-domain]  Cd Length: 105  Bit Score: 74.77  E-value: 2.62e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489610262 500 RGEINnmtQVMNNIITNAIEAYNGKGgKIDLIFSKKGHNLEITVRDYGCGIPESVKSKLFKEMVTTKG-SKGTGIGVYMA 578
Cdd:cd16943    1 PSQLN---QVLLNLLVNAAQAMEGRG-RITIRTWAHVDQVLIEVEDTGSGIDPEILGRIFDPFFTTKPvGEGTGLGLSLS 76

                         90       100       110
                 ....*....|....*....|....*....|
gi 489610262 579 YSTIKgKFGGTMTIDSKEGKGTSVNITIPL 608
Cdd:cd16943   77 YRIIQ-KHGGTIRVASVPGGGTRFTIILPI 105
PDC2_HK_sensor cd18774
second PDC (PhoQ/DcuS/CitA) domain of methyl-accepting chemotaxis proteins, ...
 222-314 7.57e-10

second PDC (PhoQ/DcuS/CitA) domain of methyl-accepting chemotaxis proteins, diguanylate-cyclase and similar domains; Histidine kinase (HK) receptors are part of two-component systems (TCS) in bacteria that play a critical role for sensing and adapting to environmental changes. Typically, HK receptors contain an extracellular sensing domain flanked by two transmembrane helices, an intracellular dimerization histidine phosphorylation domain (DHp), and a C-terminal kinase domain, with many variations on this theme. HK receptors in this family contain double PDC (PhoQ/DcuS/CitA) sensor domains. Signals detected by the sensor domain are transmitted through DHp to the kinase domain, resulting in the phosphorylation of a conserved histidine residue in DHp; phosphotransfer to a conserved aspartate in its cognate response regulator (RR) follows, which leads to the activation of genes for downstream cellular responses. The HK family includes not just histidine kinase receptors but also sensors for chemotaxis proteins and diguanylate cyclase receptors, implying a combinatorial molecular evolution.


Pssm-ID: 350342 [Multi-domain]  Cd Length: 89  Bit Score: 55.91  E-value: 7.57e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489610262 222 YIYSLISEIKLPDEGQLYIVGKDGNYVMNPFNRLQNGKVDYVKYELYIEEILKKKNGTF-IKKIDGRDYLLAFQTIDsin 300
Cdd:cd18774    1 YLSDLLSSIKLGETGYAFLVDSDGTILAHPPKELVGKGKSLDDLALLAALLLAGESGTFeYTSDDGVERLVAYRPVP--- 77

                         90
                 ....*....|....
gi 489610262 301 giELGWTVFGMTPV 314
Cdd:cd18774   78 --GTPWVVVVGVPE 89
 
Name Accession Description Interval E-value
COG4191 COG4191
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal ...
 290-609 4.83e-37

Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms];


Pssm-ID: 443345 [Multi-domain]  Cd Length: 361  Bit Score: 141.47  E-value: 4.83e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489610262 290 LLAFQTIDSINGIELGWTVFGMTPVDIITSGIESTQDILYEIGLICVIAGFVISLLITRLYNAHLEKRYERKHSIIMERE 369
Cdd:COG4191   58 LLLLLELLLLLLALLGGLLRLLLLLGLLLLLLLEALLLLLLAALDAEENAELEELERDITELERAEEELRELQEQLVQSE 137

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489610262 370 RLASLGQLMGGIAQSFKAPIMSISDGLDELNSLVDEYEKsienenvsdetrheiASRMRECLDKIKPHCSYISDEISAVK 449
Cdd:COG4191  138 KLAALGELAAGIAHEINNPLAAILGNAELLRRRLEDEPD---------------PEELREALERILEGAERAAEIVRSLR 202

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489610262 450 gqavNFNDSTDG---IFTVDELIKNVKLLMSHEIKFWNCEMNVEL-----KVSGDtsiRGEINnmtQVMNNIITNAIEAY 521
Cdd:COG4191  203 ----AFSRRDEEerePVDLNELIDEALELLRPRLKARGIEVELDLppdlpPVLGD---PGQLE---QVLLNLLINAIDAM 272

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489610262 522 -NGKGGKIDLIFSKKGHNLEITVRDYGCGIPESVKSKLFKEMVTTK-GSKGTGIGVYMAYSTIKgKFGGTMTIDSKEGKG 599
Cdd:COG4191  273 eEGEGGRITISTRREGDYVVISVRDNGPGIPPEVLERIFEPFFTTKpVGKGTGLGLSISYGIVE-KHGGRIEVESEPGGG 351

                        330
                 ....*....|
gi 489610262 600 TSVNITIPLK 609
Cdd:COG4191  352 TTFTITLPLA 361
BaeS COG0642
Signal transduction histidine kinase [Signal transduction mechanisms];
284-608 4.25e-28

Signal transduction histidine kinase [Signal transduction mechanisms];


Pssm-ID: 440407 [Multi-domain]  Cd Length: 328  Bit Score: 115.39  E-value: 4.25e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489610262 284 IDGRDYLLAFQTIDSINGIELGWTVFGMTPVDIITSGIESTQDILYEIGLICVIAGFVISLLITRLYNAHLEKRYERKHS 363
Cdd:COG0642   22 LLLLLLLLLLLALLLLLALLLLLLLLLLLLLLLALALLALLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLALLL 101

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489610262 364 IIMERERlaSLGQLMGGIAQSFKAPIMSISDGLDELnslvdeyeksienENVSDETRHEIASRMRECLDKIKphcSYISD 443
Cdd:COG0642  102 LLEEANE--AKSRFLANVSHELRTPLTAIRGYLELL-------------LEELDEEQREYLETILRSADRLL---RLIND 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489610262 444 --EISAVKGQAVNFNDSTdgiFTVDELIKNVKLLMSHEIKfwncEMNVELKVSGDTS---IRGEINNMTQVMNNIITNAI 518
Cdd:COG0642  164 llDLSRLEAGKLELEPEP---VDLAELLEEVVELFRPLAE----EKGIELELDLPDDlptVRGDPDRLRQVLLNLLSNAI 236

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489610262 519 EaYNGKGGKIDLIFSKKGHNLEITVRDYGCGIPESVKSKLFKEMVTTKGS---KGTGIGVYMAYSTIKgKFGGTMTIDSK 595
Cdd:COG0642  237 K-YTPEGGTVTVSVRREGDRVRISVEDTGPGIPPEDLERIFEPFFRTDPSrrgGGTGLGLAIVKRIVE-LHGGTIEVESE 314

                        330
                 ....*....|...
gi 489610262 596 EGKGTSVNITIPL 608
Cdd:COG0642  315 PGKGTTFTVTLPL 327
NtrB COG3852
Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms];
356-612 2.50e-27

Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms];


Pssm-ID: 443061 [Multi-domain]  Cd Length: 361  Bit Score: 113.79  E-value: 2.50e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489610262 356 KRYERKhsiIMERERLASLGQLMGGIAQSFKAPIMSISDGLDELNslvdeyeksienENVSDETRHEIASRMRECLDKIk 435
Cdd:COG3852  120 KRLERE---LRRAEKLAAVGELAAGLAHEIRNPLTGIRGAAQLLE------------RELPDDELREYTQLIIEEADRL- 183

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489610262 436 phcSYISDEI------SAVKGQAVNfndstdgiftVDELIKNVKLLMSHEIKfwnceMNVELKVSGDTS---IRGEINNM 506
Cdd:COG3852  184 ---NNLVDRLlsfsrpRPPEREPVN----------LHEVLERVLELLRAEAP-----KNIRIVRDYDPSlpeVLGDPDQL 245

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489610262 507 TQVMNNIITNAIEAYnGKGGKI----------DLIFSKKGHNLEITVRDYGCGIPESVKSKLFKEMVTTKGsKGTGIGVY 576
Cdd:COG3852  246 IQVLLNLVRNAAEAM-PEGGTItirtrverqvTLGGLRPRLYVRIEVIDNGPGIPEEILDRIFEPFFTTKE-KGTGLGLA 323

                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 489610262 577 MAYSTIKGKfGGTMTIDSKEGKGTSVNITIPLKDKD 612
Cdd:COG3852  324 IVQKIVEQH-GGTIEVESEPGKGTTFRIYLPLEQAE 358
NtrY COG5000
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism ...
 365-611 4.68e-26

Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms];


Pssm-ID: 444024 [Multi-domain]  Cd Length: 422  Bit Score: 111.21  E-value: 4.68e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489610262 365 IMERERLASLGQLMGGIAQSFK---APIMSISDgldelnSLVDEYEKSIENEnvsdetrheiASRMRECLDKIKPHCSYI 441
Cdd:COG5000  192 LLRAERLAAWGELARRIAHEIKnplTPIQLSAE------RLRRKLADKLEED----------REDLERALDTIIRQVDRL 255

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489610262 442 S---DEISAV-KGQAVNFndstdGIFTVDELIKNVKLLMSHEIKFWNCEMNVELkVSGDTSIRGEINNMTQVMNNIITNA 517
Cdd:COG5000  256 KrivDEFLDFaRLPEPQL-----EPVDLNELLREVLALYEPALKEKDIRLELDL-DPDLPEVLADRDQLEQVLINLLKNA 329

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489610262 518 IEAyNGKGGKIDLIFSKKGHNLEITVRDYGCGIPESVKSKLFKEMVTTKgSKGTGIGVYMAYSTIKgKFGGTMTIDSKEG 597
Cdd:COG5000  330 IEA-IEEGGEIEVSTRREDGRVRIEVSDNGPGIPEEVLERIFEPFFTTK-PKGTGLGLAIVKKIVE-EHGGTIELESRPG 406

                        250
                 ....*....|....
gi 489610262 598 KGTSVNITIPLKDK 611
Cdd:COG5000  407 GGTTFTIRLPLAEE 420
KdpD COG2205
K+-sensing histidine kinase KdpD [Signal transduction mechanisms];
353-610 4.15e-25

K+-sensing histidine kinase KdpD [Signal transduction mechanisms];


Pssm-ID: 441807 [Multi-domain]  Cd Length: 239  Bit Score: 104.22  E-value: 4.15e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489610262 353 HLEKRYERkhsiimERERLASLGQLMGGIAQSFKAPIMSISDGLDELNslvdeyeksiENENVSDETRHEIASRMRECLD 432
Cdd:COG2205    1 ELEEALEE------LEELERLKSEFLANVSHELRTPLTSILGAAELLL----------DEEDLSPEERRELLEIIRESAE 64

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489610262 433 KIKphcSYISD--EISAVKGQAVNFNDSTdgiFTVDELIKNVKLLMSHEIKFWNCEMNVELkVSGDTSIRGEINNMTQVM 510
Cdd:COG2205   65 RLL---RLIEDllDLSRLESGKLSLELEP---VDLAELLEEAVEELRPLAEEKGIRLELDL-PPELPLVYADPELLEQVL 137

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489610262 511 NNIITNAIEaYNGKGGKIDLIFSKKGHNLEITVRDYGCGIPESVKSKLFKEMVT---TKGSKGTGIGVYMAYSTIKgKFG 587
Cdd:COG2205  138 ANLLDNAIK-YSPPGGTITISARREGDGVRISVSDNGPGIPEEELERIFERFYRgdnSRGEGGTGLGLAIVKRIVE-AHG 215

                        250       260
                 ....*....|....*....|...
gi 489610262 588 GTMTIDSKEGKGTSVNITIPLKD 610
Cdd:COG2205  216 GTIWVESEPGGGTTFTVTLPLAE 238
KinA COG5805
Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle ...
 369-609 8.69e-24

Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];


Pssm-ID: 444507 [Multi-domain]  Cd Length: 496  Bit Score: 105.20  E-value: 8.69e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489610262 369 ERLASLGQLMGGIAQSFKAPIMSISdGLDELNSlvdeyeksienenVSDETRHEIASRMRECLDKIKphcSYISDEISAV 448
Cdd:COG5805  282 EKLSIAGQLAAGIAHEIRNPLTSIK-GFLQLLQ-------------PGIEDKEEYFDIMLSELDRIE---SIISEFLALA 344

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489610262 449 KGQAVNFNDstdgiFTVDELIKNVKLLMSHEIKFWNCEMNVELKvSGDTSIRGEINNMTQVMNNIITNAIEAYNgKGGKI 528
Cdd:COG5805  345 KPQAVNKEK-----ENINELIQDVVTLLETEAILHNIQIRLELL-DEDPFIYCDENQIKQVFINLIKNAIEAMP-NGGTI 417

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489610262 529 DLIFSKKGHNLEITVRDYGCGIPESVKSKLFKEMVTTKgSKGTGIGVYMAYSTIKgKFGGTMTIDSKEGKGTSVNITIPL 608
Cdd:COG5805  418 TIHTEEEDNSVIIRVIDEGIGIPEERLKKLGEPFFTTK-EKGTGLGLMVSYKIIE-NHNGTIDIDSKVGKGTTFTITLPL 495


                 .
gi 489610262 609 K 609
Cdd:COG5805  496 S 496
dCache_1 pfam02743
Cache domain; Double cache domain 1 covers the last three strands from the membrane distal ...
 54-311 1.13e-23

Cache domain; Double cache domain 1 covers the last three strands from the membrane distal PAS-like domain, the first two strands of the membrane proximal domain, and the connecting elements between the two domains. This domain when present in chemoreceptors recognize several signals such as proteinogenic amino acids, GABA, Histamine and polyamines, decanoic acid, Autoinducer-2, purine derivatives, quaternary amines, citrate and taurine, among others. When associated with histidine kinases, it recognizes C3/C4-dicarboxylic acids, Spermine, guanosine and Autoinducer-2 (Mantilla et al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1 https://doi.org/10.1093/femsre/fuab043).


Pssm-ID: 460673 [Multi-domain]  Cd Length: 237  Bit Score: 100.10  E-value: 1.13e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489610262   54 DAMIRHAGADNLELVKQITKNIETVMTGFDDISNEILTNENFDRLVKMHVTLDDEHkkaanrrsiesiLNGYTNTRTDIA 133
Cdd:pfam02743   1 KAIKEQAEEQLLSLAKQLAENIESYLDSLEEILELLASNPDLQDLLSAPAEEELAK------------LESLLRSNPGIS 68

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489610262  134 DIAVVTNTGEYITSGETRPLVTDNALS---YYvvKRFKQSGRDSLWLDTYQTEVASTGthtgnQLVISNIKSIKGENNEE 210
Cdd:pfam02743  69 SIYLVDADGRVLASSDESPSYPGLDVSerpWY--KEALKGGGGIIWVFSSPYPSSESG-----EPVLTIARPIYDDDGEV 141

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489610262  211 IGMLILNVKESYIYSLISEIKLPDEGQLYIVGKDGNYVMNPFNRLQNGKVDYVKYELYIEEILKKKNGTFIKKIDGRDYL 290
Cdd:pfam02743 142 IGVLVADLDLDTLQELLSQIKLGEGGYVFIVDSDGRILAHPLGKNLRSLLAPFLGKSLADALPGSGITEIAVDLDGEDYL 221

                         250       260
                  ....*....|....*....|.
gi 489610262  291 LAFQTIDSingieLGWTVFGM 311
Cdd:pfam02743 222 VAYAPIPG-----TGWTLVVV 237
HATPase_c smart00387
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
 506-609 5.49e-23

Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.


Pssm-ID: 214643 [Multi-domain]  Cd Length: 111  Bit Score: 93.87  E-value: 5.49e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489610262   506 MTQVMNNIITNAIEaYNGKGGKIDLIFSKKGHNLEITVRDYGCGIPESVKSKLFKEMVTTKGS----KGTGIGVYMAYST 581
Cdd:smart00387   6 LRQVLSNLLDNAIK-YTPEGGRITVTLERDGDHVEITVEDNGPGIPPEDLEKIFEPFFRTDKRsrkiGGTGLGLSIVKKL 84

                           90       100
                   ....*....|....*....|....*...
gi 489610262   582 IKgKFGGTMTIDSKEGKGTSVNITIPLK 609
Cdd:smart00387  85 VE-LHGGEISVESEPGGGTTFTITLPLE 111
WalK COG5002
Sensor histidine kinase WalK [Signal transduction mechanisms];
284-611 1.35e-20

Sensor histidine kinase WalK [Signal transduction mechanisms];


Pssm-ID: 444026 [Multi-domain]  Cd Length: 390  Bit Score: 94.23  E-value: 1.35e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489610262 284 IDGRDYLLAFQTIDSINGIELGWTVFGMTPVDIITSGIESTQDILYEIGLICVIAGFVISLLITRLYNAHLEKRYERKHS 363
Cdd:COG5002   77 LLLALALLLLALLLLLLLLLLLLALLILLLLLALLILLAALLLLLSELLLLLLLLGRLSLRLSALLLGLLLLAAVERDIT 156

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489610262 364 IIMERERLASlgQLMGGIAQSFKAPIMSIS-------DGLDELNSLVDEYEKSIENEnvsdetrheiASRMRecldkikp 436
Cdd:COG5002  157 ELERLEQMRR--EFVANVSHELRTPLTSIRgylelllDGAADDPEERREYLEIILEE----------AERLS-------- 216

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489610262 437 hcSYISD--EISAVKGQAVNFNDSTdgiFTVDELIKNVKLLMSHEIKFWNCEMNVELKvSGDTSIRGEINNMTQVMNNII 514
Cdd:COG5002  217 --RLVNDllDLSRLESGELKLEKEP---VDLAELLEEVVEELRPLAEEKGIELELDLP-EDPLLVLGDPDRLEQVLTNLL 290

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489610262 515 TNAIEaYNGKGGKIDLIFSKKGHNLEITVRDYGCGIPESVKSKLFK-----EMVTTKGSKGTGIGVYMAYSTIKgKFGGT 589
Cdd:COG5002  291 DNAIK-YTPEGGTITVSLREEDDQVRISVRDTGIGIPEEDLPRIFErfyrvDKSRSRETGGTGLGLAIVKHIVE-AHGGR 368

                        330       340
                 ....*....|....*....|..
gi 489610262 590 MTIDSKEGKGTSVNITIPLKDK 611
Cdd:COG5002  369 IWVESEPGKGTTFTITLPLARE 390
PRK11360 PRK11360
two-component system sensor histidine kinase AtoS;
356-612 4.77e-20

two-component system sensor histidine kinase AtoS;


Pssm-ID: 236901 [Multi-domain]  Cd Length: 607  Bit Score: 94.26  E-value: 4.77e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489610262 356 KRYERKhsiIMERERLASLGQLMGGIAQSFKAPIMSISDgldelnslvdeYEKSIENENVSDETRHEIASRMREC--LDK 433
Cdd:PRK11360 375 KRLQRR---VARQERLAALGELVAGVAHEIRNPLTAIRG-----------YVQIWRQQTSDPPSQEYLSVVLREVdrLNK 440

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489610262 434 I--------KPhcsyisdeiSAVKGQAVNFNdstdgiftvdELIKNVKLLMSHEIKFWNCemNVELKVSGD---TSIRGE 502
Cdd:PRK11360 441 VidqllefsRP---------RESQWQPVSLN----------ALVEEVLQLFQTAGVQARV--DFETELDNElppIWADPE 499

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489610262 503 InnMTQVMNNIITNAIEAYNGkGGKIDL-IFSKKGHNLEITVRDYGCGIPESVKSKLFKEMVTTKgSKGTGIGVYMAYST 581
Cdd:PRK11360 500 L--LKQVLLNILINAVQAISA-RGKIRIrTWQYSDGQVAVSIEDNGCGIDPELLKKIFDPFFTTK-AKGTGLGLALSQRI 575

                        250       260       270
                 ....*....|....*....|....*....|.
gi 489610262 582 IKGkFGGTMTIDSKEGKGTSVNITIPLKDKD 612
Cdd:PRK11360 576 INA-HGGDIEVESEPGVGTTFTLYLPINPQG 605
KinE COG5809
Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome ...
 359-609 7.63e-20

Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];


Pssm-ID: 444511 [Multi-domain]  Cd Length: 489  Bit Score: 93.12  E-value: 7.63e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489610262 359 ERKHSIIMER--ERLASLGQLMGGIAQSFKAPIMSISDGLDELNSLVDEYEKsienenvsdeTRHEIasrMRECLDKIKp 436
Cdd:COG5809  253 ERKKLEELLRksEKLSVVGELAAGIAHEIRNPLTSLKGFIQLLKDTIDEEQK----------TYLDI---MLSELDRIE- 318

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489610262 437 hcSYISDEISAVKGQAVNFNdstdgIFTVDELIKNV-KLLMSHEIkfwnceMN---VELKVSGDT-SIRGEINNMTQVMN 511
Cdd:COG5809  319 --SIISEFLVLAKPQAIKYE-----PKDLNTLIEEViPLLQPQAL------LKnvqIELELEDDIpDILGDENQLKQVFI 385

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489610262 512 NIITNAIEAYNgKGGKIDL-IFSKKGHNLEITVRDYGCGIPESVKSKLFKEMVTTKgSKGTGIGVYMAYSTIKgKFGGTM 590
Cdd:COG5809  386 NLLKNAIEAMP-EGGNITIeTKAEDDDKVVISVTDEGCGIPEERLKKLGEPFYTTK-EKGTGLGLMVSYKIIE-EHGGKI 462

                        250
                 ....*....|....*....
gi 489610262 591 TIDSKEGKGTSVNITIPLK 609
Cdd:COG5809  463 TVESEVGKGTTFSITLPIK 481
CitA COG3290
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction ...
 397-611 1.78e-19

Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction mechanisms];


Pssm-ID: 442519 [Multi-domain]  Cd Length: 389  Bit Score: 90.68  E-value: 1.78e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489610262 397 DELNSLVDEYEKSienENVSDETR---HEIASRMR--------ECLDKIKphcSYISDEISAVKgQAVNFNDSTDGIFTV 465
Cdd:COG3290  174 TELERLEEELEGV---KELAEALRaqrHDFRNHLHtisgllqlGEYDEAL---EYIDEISEELQ-ELIDSLLSRIGNPVL 246

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489610262 466 DELIkNVKLLMSHEikfwnceMNVELKVSGDTSIRG---EINNMTQVMNNIITNAIEA---YNGKGGKIDLIFSKKGHNL 539
Cdd:COG3290  247 AALL-LGKAARARE-------RGIDLTIDIDSDLPDlplSDTDLVTILGNLLDNAIEAvekLPEEERRVELSIRDDGDEL 318

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 489610262 540 EITVRDYGCGIPESVKSKLFKEMVTTKGSKGTGIGVYMAYSTIKgKFGGTMTIDSKEGKGTSVNITIPLKDK 611
Cdd:COG3290  319 VIEVEDSGPGIPEELLEKIFERGFSTKLGEGRGLGLALVKQIVE-KYGGTIEVESEEGEGTVFTVRLPKEGE 389
HATPase_c pfam02518
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the ...
 508-609 2.24e-18

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.


Pssm-ID: 460579 [Multi-domain]  Cd Length: 109  Bit Score: 80.88  E-value: 2.24e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489610262  508 QVMNNIITNAIEaYNGKGGKIDLIFSKKGHnLEITVRDYGCGIPESVKSKLFKEMVTTKGSK--GTGIGVYMAYSTIKgK 585
Cdd:pfam02518   8 QVLSNLLDNALK-HAAKAGEITVTLSEGGE-LTLTVEDNGIGIPPEDLPRIFEPFSTADKRGggGTGLGLSIVRKLVE-L 84

                          90       100
                  ....*....|....*....|....
gi 489610262  586 FGGTMTIDSKEGKGTSVNITIPLK 609
Cdd:pfam02518  85 LGGTITVESEPGGGTTVTLTLPLA 108
PRK10364 PRK10364
two-component system sensor histidine kinase ZraS;
356-609 8.09e-17

two-component system sensor histidine kinase ZraS;


Pssm-ID: 236674 [Multi-domain]  Cd Length: 457  Bit Score: 83.30  E-value: 8.09e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489610262 356 KRYERKHSII---MER-ERLASLGQLMGGIAQSFKAPIMSISDgldelnslvdeYEKSIENENVSDETRHEIASRMRECL 431
Cdd:PRK10364 215 RRYLRSRQLLqdeMKRkEKLVALGHLAAGVAHEIRNPLSSIKG-----------LAKYFAERAPAGGEAHQLAQVMAKEA 283

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489610262 432 DKIKphcSYISDEISAVKG-----QAVNFNDstdgiftvdeLIKNVKLLMSHEIKfwNCEMNVELKVS-GDTSIRGEINN 505
Cdd:PRK10364 284 DRLN---RVVSELLELVKPthlalQAVDLND----------LINHSLQLVSQDAN--SREIQLRFTANdTLPEIQADPDR 348

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489610262 506 MTQVMNNIITNAIEAYnGKGGKIDLIFSKKGHNLEITVRDYGCGIPESVKSKLFKEMVTTKGsKGTGIGVYMAYsTIKGK 585
Cdd:PRK10364 349 LTQVLLNLYLNAIQAI-GQHGVISVTASESGAGVKISVTDSGKGIAADQLEAIFTPYFTTKA-EGTGLGLAVVH-NIVEQ 425

                        250       260
                 ....*....|....*....|....
gi 489610262 586 FGGTMTIDSKEGKGTSVNITIPLK 609
Cdd:PRK10364 426 HGGTIQVASQEGKGATFTLWLPVN 449
COG4251 COG4251
Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal ...
 386-610 2.20e-16

Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms];


Pssm-ID: 443393 [Multi-domain]  Cd Length: 503  Bit Score: 82.14  E-value: 2.20e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489610262 386 KAPIMSISdGLDELnsLVDEYEksienENVSDETRHEI------ASRMREcldkikphcsYISD--EISAVKGQAVNFnD 457
Cdd:COG4251  294 REPLRKIS-GFSQL--LEEDYG-----DKLDEEGREYLerirdaAERMQA----------LIDDllAYSRVGRQELEF-E 354

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489610262 458 STDgiftVDELIKNVKLLMSHEIKfwncEMNVELKVSGDTSIRGEINNMTQVMNNIITNAIEaYNGKG--GKIDLIFSKK 535
Cdd:COG4251  355 PVD----LNELLEEVLEDLEPRIE----ERGAEIEVGPLPTVRGDPTLLRQVFQNLISNAIK-YSRPGepPRIEIGAERE 425

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 489610262 536 GHNLEITVRDYGCGIPESVKSKLFKEMVTTKGS---KGTGIGVYMAYSTIKgKFGGTMTIDSKEGKGTSVNITIPLKD 610
Cdd:COG4251  426 GGEWVFSVRDNGIGIDPEYAEKIFEIFQRLHSRdeyEGTGIGLAIVKKIVE-RHGGRIWVESEPGEGATFYFTLPKAP 502
HATPase_AtoS-like cd16943
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 500-608 2.62e-16

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 AtoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Escherichia coli AtoS, an HK of the AtoS-AtoC TCS. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have accessory domains such as HAMP or PAS sensor domains or CBS-pair domains.


Pssm-ID: 340419 [Multi-domain]  Cd Length: 105  Bit Score: 74.77  E-value: 2.62e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489610262 500 RGEINnmtQVMNNIITNAIEAYNGKGgKIDLIFSKKGHNLEITVRDYGCGIPESVKSKLFKEMVTTKG-SKGTGIGVYMA 578
Cdd:cd16943    1 PSQLN---QVLLNLLVNAAQAMEGRG-RITIRTWAHVDQVLIEVEDTGSGIDPEILGRIFDPFFTTKPvGEGTGLGLSLS 76

                         90       100       110
                 ....*....|....*....|....*....|
gi 489610262 579 YSTIKgKFGGTMTIDSKEGKGTSVNITIPL 608
Cdd:cd16943   77 YRIIQ-KHGGTIRVASVPGGGTRFTIILPI 105
HATPase_DpiB-CitA-like cd16915
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 509-607 1.20e-14

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 DpiB, DcuS, and Bacillus subtilis CitS, DctS, and YufL; This family includes histidine kinase-like ATPase domains of Escherichia coli K-12 DpiB and DcuS, and Bacillus subtilis CitS, DctS and MalK histidine kinases (HKs) all of which are two component transduction systems (TCSs). E. coli K-12 DpiB (also known as CitA) is the histidine kinase (HK) of DpiA-DpiB, a two-component signal transduction system (TCS) required for the expression of citrate-specific fermentation genes and genes involved in plasmid inheritance. E. coli K-12 DcuS (also known as YjdH) is the HK of DcuS-DcuR, a TCS that in the presence of the extracellular C4-dicarboxlates, activates the expression of the genes of anaerobic fumarate respiration and of aerobic C4-dicarboxylate uptake. CitS is the HK of Bacillus subtilis CitS-CitT, a TCS which regulates expression of CitM, the Mg-citrate transporter. Bacillus subtilis DctS forms a tripartite sensor unit (DctS/DctA/DctB) for sensing C4 dicarboxylates. Bacillus subtilis MalK (also known as YfuL) is the HK of MalK-MalR (YufL-YufM) a TCS which regulates the expression of the malate transporters MaeN (YufR) and YflS, and is essential for utilization of malate in minimal medium. Proteins having this DpiB-CitA-like HATPase domain generally have sensor domains such as Cache and PAS, and a histidine kinase A (HisKA)-like SpoOB-type, alpha-helical domain.


Pssm-ID: 340392 [Multi-domain]  Cd Length: 104  Bit Score: 70.01  E-value: 1.20e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489610262 509 VMNNIITNAIEAYNGKG---GKIDLIFSKKGHNLEITVRDYGCGIPESVKSKLFKEMVTTKGSKGTGIGVYMAYSTIKgK 585
Cdd:cd16915    4 IVGNLIDNALDALAATGapnKQVEVFLRDEGDDLVIEVRDTGPGIAPELRDKVFERGVSTKGQGERGIGLALVRQSVE-R 82

                         90       100
                 ....*....|....*....|..
gi 489610262 586 FGGTMTIDSKEGKGTSVNITIP 607
Cdd:cd16915   83 LGGSITVESEPGGGTTFSIRIP 104
HATPase_CckA-like cd16919
Histidine kinase-like ATPase domain of two-component sensor hybrid histidine kinases, similar ...
 512-607 1.07e-13

Histidine kinase-like ATPase domain of two-component sensor hybrid histidine kinases, similar to Brucella abortus 2308 CckA; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinase (HKs) similar to Brucella abortus 2308 CckA, which is a component of an essential protein phosphorelay that regulates expression of genes required for growth, division, and intracellular survival; phosphoryl transfer initiates from the sensor kinase CckA and proceeds via the ChpT phosphotransferase to two regulatory substrates: the DNA-binding response regulator CtrA and the phospho-receiver protein CpdR. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), a REC signal receiver domain, and some contain PAS or PAS and GAF sensor domain(s).


Pssm-ID: 340396 [Multi-domain]  Cd Length: 116  Bit Score: 67.79  E-value: 1.07e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489610262 512 NIITNAIEAYnGKGGKIDLIFSKK---------------GHNLEITVRDYGCGIPESVKSKLFKEMVTTKG-SKGTGIGV 575
Cdd:cd16919    7 NLAVNARDAM-PEGGRLTIETSNQrvdadyalnyrdlipGNYVCLEVSDTGSGMPAEVLRRAFEPFFTTKEvGKGTGLGL 85

                         90       100       110
                 ....*....|....*....|....*....|..
gi 489610262 576 YMAYSTIKgKFGGTMTIDSKEGKGTSVNITIP 607
Cdd:cd16919   86 SMVYGFVK-QSGGHLRIYSEPGVGTTVRIYLP 116
PRK13557 PRK13557
histidine kinase; Provisional
 314-616 3.27e-13

histidine kinase; Provisional


Pssm-ID: 237425 [Multi-domain]  Cd Length: 540  Bit Score: 72.40  E-value: 3.27e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489610262 314 VDIITSGIESTQDILYEI------GlicviAGFVISLLITRLYNAHLEKRYERKHSIIMERERLA-----------SLGQ 376
Cdd:PRK13557  91 VAEVRDAIAERREIATEIlnyrkdG-----SSFWNALFVSPVYNDAGDLVYFFGSQLDVSRRRDAedalrqaqkmeALGQ 165

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489610262 377 LMGGIAQSFKAPIMSISDGLDELNSLVDEyeksienenvsdetRHEIASRMRECLDKIKP---HCSYISDEISA------ 447
Cdd:PRK13557 166 LTGGIAHDFNNLLQVMSGYLDVIQAALSH--------------PDADRGRMARSVENIRAaaeRAATLTQQLLAfarkqr 231

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489610262 448 VKGQAVNFNDSTDGIFTVDE--LIKNVKLLMSHEIKFWNCEMnvelkvsgDTsirgeinnmTQV---MNNIITNAIEAYN 522
Cdd:PRK13557 232 LEGRVLNLNGLVSGMGELAErtLGDAVTIETDLAPDLWNCRI--------DP---------TQAevaLLNVLINARDAMP 294

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489610262 523 GKG-----------GKIDL-IFS--KKGHNLEITVRDYGCGIPESVKSKLFKEMVTTKGS-KGTGIGVYMAYSTIKgKFG 587
Cdd:PRK13557 295 EGGrvtirtrnveiEDEDLaMYHglPPGRYVSIAVTDTGSGMPPEILARVMDPFFTTKEEgKGTGLGLSMVYGFAK-QSG 373

                        330       340
                 ....*....|....*....|....*....
gi 489610262 588 GTMTIDSKEGKGTSVNITIPLKDKDFTPP 616
Cdd:PRK13557 374 GAVRIYSEVGEGTTVRLYFPASDQAENPE 402
HATPase_BceS-YxdK-YvcQ-like cd16948
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 509-607 2.30e-12

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis BceS, YxdK, and Bacillus thuringiensis YvcQ; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis BceS and Bacillus thuringiensis YvcQ, the HKs of the two-component regulatory system (TCSs) BceS-BceR and YvcQ-YvcP, repsectively, which are both involved in regulating bacitracin resistance. It also includes the HATPase domain of YxdK, the HK of YxdK-YxdJ TCS involved in sensing antimicrobial compounds.


Pssm-ID: 340424 [Multi-domain]  Cd Length: 109  Bit Score: 63.84  E-value: 2.30e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489610262 509 VMNNIITNAIEaYNGKGGKIDLIFSKKGHNLEITVRDYGCGIPESVKSKLFKEMVTT----KGSKGTGIGVYMAYStIKG 584
Cdd:cd16948    9 IIGQIVSNALK-YSKQGGKIEIYSETNEQGVVLSIKDFGIGIPEEDLPRVFDKGFTGengrNFQESTGMGLYLVKK-LCD 86

                         90       100
                 ....*....|....*....|...
gi 489610262 585 KFGGTMTIDSKEGKGTSVNITIP 607
Cdd:cd16948   87 KLGHKIDVESEVGEGTTFTITFP 109
PRK11086 PRK11086
sensory histidine kinase DcuS; Provisional
 486-614 2.47e-12

sensory histidine kinase DcuS; Provisional


Pssm-ID: 236839 [Multi-domain]  Cd Length: 542  Bit Score: 69.56  E-value: 2.47e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489610262 486 EMNVELKVSGDTSI-----RGEINNMTQVMNNIITNAIEAYNGKGGK-IDLIFSKKGHNLEITVRDYGCGIPESVKSKLF 559
Cdd:PRK11086 409 ELGITLIISEDSQLpdsgdEDQVHELITILGNLIENALEAVGGEEGGeISVSLHYRNGWLHCEVSDDGPGIAPDEIDAIF 488

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 489610262 560 KEMVTTKGsKGTGIGVYMAYSTIKgKFGGTMTIDSKEGKGTSVNITIPLKDKDFT 614
Cdd:PRK11086 489 DKGYSTKG-SNRGVGLYLVKQSVE-NLGGSIAVESEPGVGTQFFVQIPWDGERSN 541
dpiB PRK15053
sensor histidine kinase DpiB; Provisional
 504-607 4.26e-12

sensor histidine kinase DpiB; Provisional


Pssm-ID: 185013 [Multi-domain]  Cd Length: 545  Bit Score: 68.71  E-value: 4.26e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489610262 504 NNMTQVMNNIITNAIEAY--NGKGGK-IDLIFSKKGHNLEITVRDYGCGIPESVKSKLFKEMVTTKGSKGT--GIGVYMA 578
Cdd:PRK15053 431 TEFAAIVGNLLDNAFEASlrSDEGNKiVELFLSDEGDDVVIEVADQGCGVPESLRDKIFEQGVSTRADEPGehGIGLYLI 510

                         90       100
                 ....*....|....*....|....*....
gi 489610262 579 YSTIkGKFGGTMTIDSKEGKGTSVNITIP 607
Cdd:PRK15053 511 ASYV-TRCGGVITLEDNDPCGTLFSIFIP 538
YesM COG2972
Sensor histidine kinase YesM [Signal transduction mechanisms];
211-611 4.78e-11

Sensor histidine kinase YesM [Signal transduction mechanisms];


Pssm-ID: 442211 [Multi-domain]  Cd Length: 445  Bit Score: 65.04  E-value: 4.78e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489610262 211 IGMLILNVKESYIYSLISEIKLPDEGQLYIVGKDGNYVMNPFNRLQNGKVDYVKYELYIEEILKkkNGTFIKKIDGRDYL 290
Cdd:COG2972   44 LLLLILLLLLLLLLLLLLLLLLLLLLLLLLLLLLALLLILLLLLLLLLLLILLLSLLLLLALIL--LLALLLLLSILLLI 121

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489610262 291 LAFQTIDSINGIELGWTVFGMTPVDIITSGIESTQDILYEIGLICVIAGFVISLLITRLYNAHLekryeRKHSIIMERER 370
Cdd:COG2972  122 LGLLLIILLLLSLLGWTLVSLIPKSELFRGLFSLRRLILLIILLLLLLALLLSYLLSRSITRPI-----KRLKKAMKKVE 196

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489610262 371 LASLGQLMGGIAQSFKAPIMSISDGLDELNSLVDE-YEKSIENEN------------------------VSDETRHEIAS 425
Cdd:COG2972  197 KGDLVRLEVSGNDEIGILARSFNEMVERIKELIEEvYELELEKKEaelkalqaqinphflfntlnsirwLAELEDPEEAE 276

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489610262 426 RM--------RECLDKIKPHCSyISDEISAVKG----QAVNFNDSTDGIFTVDELIKNVKLLmsheiKFwncemnvelkv 493
Cdd:COG2972  277 EMlealskllRYSLSKGDELVT-LEEELELIKSyleiQKLRFGDRLEVEIEIDEELLDLLIP-----KL----------- 339

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489610262 494 sgdtsirgeinnmtqVMNNIITNAIEA---YNGKGGKIDLIFSKKGHNLEITVRDYGCGIPESVKSKLFKEMvtTKGSKG 570
Cdd:COG2972  340 ---------------ILQPLVENAIEHgiePKEGGGTIRISIRKEGDRLVITVEDNGVGMPEEKLEKLLEEL--SSKGEG 402

                        410       420       430       440
                 ....*....|....*....|....*....|....*....|...
gi 489610262 571 TGIGVYMAYSTIKGKFGG--TMTIDSKEGKGTSVNITIPLKDK 611
Cdd:COG2972  403 RGIGLRNVRERLKLYYGEeyGLEIESEPGEGTTVTIRIPLEEE 445
HATPase_HupT_MifS-like cd16976
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 508-599 2.00e-10

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhodobacter capsulatus HupT and Pseudomonas aeruginosa MifS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Rhodobacter capsulatus HupT of the HupT-HupR two-component regulatory system (TCS), which regulates the synthesis of HupSL, a membrane bound [NiFe]hydrogenase. It also contains the HATPase domain of Pseudomonas aeruginosa MifS, the HK of the MifS-MifR TCS, which may be involved in sensing alpha-ketoglutarate and regulating its transport and subsequent metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some also have a C-terminal PAS sensor domain.


Pssm-ID: 340435 [Multi-domain]  Cd Length: 102  Bit Score: 57.85  E-value: 2.00e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489610262 508 QVMNNIITNAIEAYNG-KGGKIDLIFSKKGHNLEITVRDYGCGIPESVKSKLFKEMVTTKG-SKGTGIGVYMAYSTIKgK 585
Cdd:cd16976    3 QVLMNLLQNALDAMGKvENPRIRIAARRLGGRLVLVVRDNGPGIAEEHLSRVFDPFFTTKPvGKGTGLGLSISYGIVE-E 81

                         90
                 ....*....|....
gi 489610262 586 FGGTMTIDSKEGKG 599
Cdd:cd16976   82 HGGRLSVANEEGAG 95
HATPase_TmoS-FixL-DctS-like cd16920
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 508-607 3.06e-10

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhizobium meliloti FixL, and Rhodobacter capsulatus DctS; includes hybrid sensor histidine kinase similar to Pseudomonas mendocina TmoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs), such as Pseudomonas mendocina TmoS HK of the TmoS-TmoT TCS, which controls the expression of the toluene-4-monooxygenase pathway, Rhizobium meliloti FixL HK of the FixL-FixJ TCS, which regulates the expression of the genes related to nitrogen fixation in the root nodule in response to O(2) levels, and Rhodobacter capsulatus DctS of the DctS-DctR TCS, which controls synthesis of the high-affinity C4-dicarboxylate transport system. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and PAS sensor domain(s); many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.


Pssm-ID: 340397 [Multi-domain]  Cd Length: 104  Bit Score: 57.41  E-value: 3.06e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489610262 508 QVMNNIITNAIEA---YNGKGGKIDLIFSKKGHN-LEITVRDYGCGIPESVKSKLFKEMVTTKgSKGTGIGVYMAYSTIK 583
Cdd:cd16920    3 QVLINLVRNGIEAmseGGCERRELTIRTSPADDRaVTISVKDTGPGIAEEVAGQLFDPFYTTK-SEGLGMGLSICRSIIE 81

                         90       100
                 ....*....|....*....|....
gi 489610262 584 GKfGGTMTIDSKEGKGTSVNITIP 607
Cdd:cd16920   82 AH-GGRLSVESPAGGGATFQFTLP 104
HATPase_EvgS-ArcB-TorS-like cd16922
Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid ...
 508-608 3.28e-10

Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid sensor histidine kinases, similar to Escherichia coli EvgS, ArcB, TorS, BarA, RcsC; This family contains the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinases (HKs), including the following Escherichia coli HKs: EvgS, a HK of the EvgS-EvgA two-component system (TCS) that confers acid resistance; ArcB, a HK of the ArcB-ArcA TCS that modulates the expression of numerous genes in response to respiratory growth conditions; TorS, a HK of the TorS-TorR TCS which is involved in the anaerobic utilization of trimethylamine-N-oxide; BarA, a HK of the BarA-UvrY TCS involved in the regulation of carbon metabolism; and RcsC, a HK of the RcsB-RcsC TCS which regulates the expression of the capsule operon and of the cell division gene ftsZ. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), with most having accessory sensor domain(s) such as GAF, PAS and CHASE; many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.


Pssm-ID: 340399 [Multi-domain]  Cd Length: 110  Bit Score: 57.50  E-value: 3.28e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489610262 508 QVMNNIITNAIEaYNGKGG---KIDLIFSKKGHN-LEITVRDYGCGIPESVKSKLFK-----EMVTTKGSKGTGIGVyma 578
Cdd:cd16922    3 QILLNLLGNAIK-FTEEGEvtlRVSLEEEEEDGVqLRFSVEDTGIGIPEEQQARLFEpfsqaDSSTTRKYGGTGLGL--- 78

                         90       100       110
                 ....*....|....*....|....*....|....
gi 489610262 579 ysTIKGKF----GGTMTIDSKEGKGTSVNITIPL 608
Cdd:cd16922   79 --AISKKLvelmGGDISVESEPGQGSTFTFTLPL 110
HATPase_Glnl-NtrB-like cd16918
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 506-607 5.36e-10

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli GlnL (synonyms NtrB and NRII); This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs), similar to Escherichia coli GlnL/NtrB/NRII HK of the two-component regulatory system (TCS) GlnL/GlnG (NtrB-NtrC, or NRII-NRI), which regulates the transcription of genes encoding metabolic enzymes and permeases in response to carbon and nitrogen status in E. coli and related bacteria. Also included in this family are Rhodobacter capsulatus NtrB, Azospirillum brasilense NtrB, Vibrio alginolyticus NtrB, Rhizobium leguminosarum biovar phaseoli NtrB, and Herbaspirillum seropedicae NtrB. Escherichia coli GlnL/NtrB/NRII is both a kinase and a phosphatase, catalyzing the phosphorylation and dephosphorylation of GlnG/NtrC/NRI. The kinase and phosphatase activities of GlnL/NtrB/NRII are regulated by the PII signal transduction protein, which on binding to GlnL/NtrB/NRII, inhibits the kinase activity of GlnL/NtrB/NRII and activates the GlnL/NtrB/NRII phosphatase activity. Proteins having this HATPase domain also have a histidine kinase dimerization and phosphoacceptor domain (HisKA); some also contain PAS sensor domain(s).


Pssm-ID: 340395 [Multi-domain]  Cd Length: 109  Bit Score: 57.03  E-value: 5.36e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489610262 506 MTQVMNNIITNAIEAYNGKGGKIDL--------IFSKKGHNL--EITVRDYGCGIPESVKSKLFKEMVTTKgSKGTGIGV 575
Cdd:cd16918    1 LIQVFLNLVRNAAQALAGSGGEIILrtrtqrqvTLGHPRHRLalRVSVIDNGPGIPPDLQDTIFYPMVSGR-ENGTGLGL 79

                         90       100       110
                 ....*....|....*....|....*....|..
gi 489610262 576 YMAySTIKGKFGGTMTIDSKEGKgTSVNITIP 607
Cdd:cd16918   80 AIA-QNIVSQHGGVIECDSQPGH-TVFSVSLP 109
PDC2_HK_sensor cd18774
second PDC (PhoQ/DcuS/CitA) domain of methyl-accepting chemotaxis proteins, ...
 222-314 7.57e-10

second PDC (PhoQ/DcuS/CitA) domain of methyl-accepting chemotaxis proteins, diguanylate-cyclase and similar domains; Histidine kinase (HK) receptors are part of two-component systems (TCS) in bacteria that play a critical role for sensing and adapting to environmental changes. Typically, HK receptors contain an extracellular sensing domain flanked by two transmembrane helices, an intracellular dimerization histidine phosphorylation domain (DHp), and a C-terminal kinase domain, with many variations on this theme. HK receptors in this family contain double PDC (PhoQ/DcuS/CitA) sensor domains. Signals detected by the sensor domain are transmitted through DHp to the kinase domain, resulting in the phosphorylation of a conserved histidine residue in DHp; phosphotransfer to a conserved aspartate in its cognate response regulator (RR) follows, which leads to the activation of genes for downstream cellular responses. The HK family includes not just histidine kinase receptors but also sensors for chemotaxis proteins and diguanylate cyclase receptors, implying a combinatorial molecular evolution.


Pssm-ID: 350342 [Multi-domain]  Cd Length: 89  Bit Score: 55.91  E-value: 7.57e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489610262 222 YIYSLISEIKLPDEGQLYIVGKDGNYVMNPFNRLQNGKVDYVKYELYIEEILKKKNGTF-IKKIDGRDYLLAFQTIDsin 300
Cdd:cd18774    1 YLSDLLSSIKLGETGYAFLVDSDGTILAHPPKELVGKGKSLDDLALLAALLLAGESGTFeYTSDDGVERLVAYRPVP--- 77

                         90
                 ....*....|....
gi 489610262 301 giELGWTVFGMTPV 314
Cdd:cd18774   78 --GTPWVVVVGVPE 89
PRK15347 PRK15347
two component system sensor kinase;
508-616 2.65e-09

two component system sensor kinase;


Pssm-ID: 237951 [Multi-domain]  Cd Length: 921  Bit Score: 60.43  E-value: 2.65e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489610262 508 QVMNNIITNAIEaYNGKGGkIDLIFSKKGHNLEITVRDYGCGIPESVKSKLFKEMVTTKG-SKGTGIGVYMAySTIKGKF 586
Cdd:PRK15347 516 QILVNLLGNAVK-FTETGG-IRLRVKRHEQQLCFTVEDTGCGIDIQQQQQIFTPFYQADThSQGTGLGLTIA-SSLAKMM 592

                         90       100       110
                 ....*....|....*....|....*....|
gi 489610262 587 GGTMTIDSKEGKGTSVNITIPLkdKDFTPP 616
Cdd:PRK15347 593 GGELTLFSTPGVGSCFSLVLPL--NEYAPP 620
HATPase_NtrY-like cd16944
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 506-607 4.58e-09

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Azorhizobium caulinodans NtrY; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Azorhizobium caulinodans ORS571 NtrY of the NtrY-NtrX TCS, which is involved in nitrogen fixation and metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also have PAS sensor domains.


Pssm-ID: 340420 [Multi-domain]  Cd Length: 108  Bit Score: 54.47  E-value: 4.58e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489610262 506 MTQVMNNIITNAIEAYNGK-GGKIDL-IFSKKG--HNLEITVRDYGCGIPESVKSKLFKEMVTTKgSKGTGIGVYMAYST 581
Cdd:cd16944    5 ISQVLTNILKNAAEAIEGRpSDVGEVrIRVEADqdGRIVLIVCDNGKGFPREMRHRATEPYVTTR-PKGTGLGLAIVKKI 83

                         90       100
                 ....*....|....*....|....*.
gi 489610262 582 IKgKFGGTMTIDSKEGKGTSVNITIP 607
Cdd:cd16944   84 ME-EHGGRISLSNREAGGACIRIILP 108
PDC2_MCP_like cd12912
second PDC (PhoQ/DcuS/CitA) domain of methyl-accepting chemotaxis proteins and similar domains; ...
 222-315 5.72e-09

second PDC (PhoQ/DcuS/CitA) domain of methyl-accepting chemotaxis proteins and similar domains; Members of this subfamily display varying domain architectures but all contain double PDC (PhoQ/DcuS/CitA) sensor domains. This model represents the second PDC domain of Methyl-accepting chemotaxis proteins (MCPs), Histidine kinases (HKs), and other similar domains. Many members contain both HAMP (HK, Adenylyl cyclase, MCP, and Phosphatase) and MCP domains, which are signalling domains that interact with protein partners to relay a signal. MCPs are part of a transmembrane protein complex that controls bacterial chemotaxis. HK receptors are part of two-component systems (TCS) in bacteria that play a critical role for sensing and adapting to environmental changes. Typically, HK receptors contain an extracellular sensing domain flanked by two transmembrane helices, an intracellular dimerization histidine phosphorylation domain (DHp), and a C-terminal kinase domain, with many variations on this theme. In the case of HKs, signals detected by the sensor domain are transmitted through DHp to the kinase domain, resulting in the phosphorylation of a conserved histidine residue in DHp; phosphotransfer to a conserved aspartate in its cognate response regulator (RR) follows, which leads to the activation of genes for downstream cellular responses.


Pssm-ID: 350337 [Multi-domain]  Cd Length: 92  Bit Score: 53.54  E-value: 5.72e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489610262 222 YIYSLISEIKLPDEGQLYIVGKDGNYVMNPfNR---LQNGKVDYVKYELYIEEILKKKNGTFIKKIDGRDYLLAFQTIDs 298
Cdd:cd12912    1 ELSEIISSIKIGETGYAFLVDKDGTIIAHP-DKelvGKKISDDEAAEEELAKKMLAGKSGSVEYTFNGEKKYVAYAPIP- 78

                         90
                 ....*....|....*..
gi 489610262 299 ingiELGWTVFGMTPVD 315
Cdd:cd12912   79 ----GTGWSLVVVVPES 91
PRK13837 PRK13837
two-component system VirA-like sensor kinase;
488-611 8.87e-09

two-component system VirA-like sensor kinase;


Pssm-ID: 237526 [Multi-domain]  Cd Length: 828  Bit Score: 58.54  E-value: 8.87e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489610262 488 NVELKVSGD---TSIRGEINNMTQVMNNIITNAIEAYNGkGGKIDLIFSKK---------------GHNLEITVRDYGCG 549
Cdd:PRK13837 540 GVELDFDQDqepAVVEGNPAELQQVLMNLCSNAAQAMDG-AGRVDISLSRAklrapkvlshgvlppGRYVLLRVSDTGAG 618

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 489610262 550 IPESVKSKLFKEMVTTKgSKGTGIGVYMAYSTIKGkFGGTMTIDSKEGKGTSVNITIPLKDK 611
Cdd:PRK13837 619 IDEAVLPHIFEPFFTTR-AGGTGLGLATVHGIVSA-HAGYIDVQSTVGRGTRFDVYLPPSSK 678
HATPase_FilI-like cd16921
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 506-607 1.09e-08

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Methanosaeta harundinacea FilI and some hybrid sensor histidine kinases; This family includes FilI, the histidine kinase (HK) component of FilI-FilRs, a two-component signal transduction system (TCS) of the methanogenic archaeon, Methanosaeta harundinacea, which is involved in regulating methanogenesis. The cytoplasmic HK core consists of a C-terminal HK-like ATPase domain (represented here) and a histidine kinase dimerization and phosphoacceptor domain (HisKA) domain, which, in FilI, are coupled to CHASE, HAMP, PAS, and GAF sensor domains. FilI-FilRs catalyzes the phosphotransfer between FilI (HK) and FilRs (FilR1 and FilR2, response regulators) of the TCS. TCSs are predicted to be of bacterial origin, and acquired by archaea by horizontal gene transfer. This model also includes related HATPase domains such as that of Synechocystis sp. PCC6803 phytochrome-like protein Cph1. Proteins having this HATPase domain and HisKA domain also have accessory sensor domains such as CHASE, GAF, HAMP and PAS; some are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.


Pssm-ID: 340398 [Multi-domain]  Cd Length: 105  Bit Score: 53.10  E-value: 1.09e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489610262 506 MTQVMNNIITNAIEaYNGKG--GKIDLIFSKKGHNLEITVRDYGCGIPESVKSK---LFKEMVTTKGSKGTGIGVYMAYS 580
Cdd:cd16921    1 LGQVLTNLLGNAIK-FRRPRrpPRIEVGAEDVGEEWTFYVRDNGIGIDPEYAEKvfgIFQRLHSREEYEGTGVGLAIVRK 79

                         90       100
                 ....*....|....*....|....*..
gi 489610262 581 TIKgKFGGTMTIDSKEGKGTSVNITIP 607
Cdd:cd16921   80 IIE-RHGGRIWLESEPGEGTTFYFTLP 105
HATPase_LytS-like cd16957
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 513-607 1.37e-08

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis LytS and Staphylococcus aureus LytS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis LytS, a HK of the two-component system (TCS) LytS-LytR needed for growth on pyruvate, and Staphylococcus aureus LytS-LytR TCS involved in the adaptation of S. aureus to cationic antimicrobial peptides. Proteins having this HATPase domain also contain a histidine kinase domain (His-kinase), and a GAF sensor domain; most contain a DUF3816 domain.


Pssm-ID: 340433 [Multi-domain]  Cd Length: 106  Bit Score: 52.81  E-value: 1.37e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489610262 513 IITNAIE-AYNGK--GGKIDLIFSKKGHNLEITVRDYGCGIPESVKSKLFKEMVTTKgsKGTGIGVYMAYSTIKGKFG-- 587
Cdd:cd16957    9 LVENAIRhAFPKRkeNNEVRVVVKKDQHKVHVSVSDNGQGIPEERLDLLGKTTVTSE--KGTGTALENLNRRLIGLFGse 86

                         90       100
                 ....*....|....*....|
gi 489610262 588 GTMTIDSKEGKGTSVNITIP 607
Cdd:cd16957   87 ACLHIESEVHGGTEVWFVIP 106
COG3920 COG3920
Two-component sensor histidine kinase, HisKA and HATPase domains [Signal transduction ...
 509-610 6.84e-08

Two-component sensor histidine kinase, HisKA and HATPase domains [Signal transduction mechanisms];


Pssm-ID: 443125 [Multi-domain]  Cd Length: 495  Bit Score: 55.30  E-value: 6.84e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489610262 509 VMNNIITNAIE--AYNGKGGKIDLIFSKKGHNLEITVRDYGCGIPESVKSKlfkemvttkgsKGTGIGVYMAYSTIkGKF 586
Cdd:COG3920  403 ILNELVTNALKhaFLSGEGGRIRVSWRREDGRLRLTVSDNGVGLPEDVDPP-----------ARKGLGLRLIRALV-RQL 470

                         90       100
                 ....*....|....*....|....
gi 489610262 587 GGTMTIDSKEgkGTSVNITIPLKD 610
Cdd:COG3920  471 GGTLELDRPE--GTRVRITFPLAE 492
ComP COG4585
Signal transduction histidine kinase ComP [Signal transduction mechanisms];
333-611 1.10e-07

Signal transduction histidine kinase ComP [Signal transduction mechanisms];


Pssm-ID: 443642 [Multi-domain]  Cd Length: 252  Bit Score: 53.47  E-value: 1.10e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489610262 333 LICVIAGFVISLLITRL----YNAHLEKRYERKHSIIM--ERERLA-----SLGQLMGGIAQSFKAPIMSISDGLDELNS 401
Cdd:COG4585   13 LVGALLGLLLALVLLRArraeRAAELERELAARAEEAReeERRRIArelhdGVGQSLSAIKLQLEAARRLLDADPEAARE 92

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489610262 402 LVDEYEKSIENenVSDETRhEIASRMREcldkikphcSYISDE--ISAVKGQAVNFNDSTDgiftvdeliknvkllmshe 479
Cdd:COG4585   93 ELEEIRELARE--ALAELR-RLVRGLRP---------PALDDLglAAALEELAERLLRAAG------------------- 141

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489610262 480 ikfwnceMNVELKVSGDtsiRGEINNMTQV---------MNNIITNAieayngKGGKIDLIFSKKGHNLEITVRDYGCGI 550
Cdd:COG4585  142 -------IRVELDVDGD---PDRLPPEVELalyrivqeaLTNALKHA------GATRVTVTLEVDDGELTLTVRDDGVGF 205

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 489610262 551 PesvksklfkemVTTKGSKGTGIgvymaySTIKG---KFGGTMTIDSKEGKGTSVNITIPLKDK 611
Cdd:COG4585  206 D-----------PEAAPGGGLGL------RGMREraeALGGTLTIGSAPGGGTRVRATLPLAAA 252
HATPase_YcbM-like cd16947
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 483-606 1.53e-07

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis YcbM; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis YcbM, a HK of the two-component system YcbM-YcbL. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA).


Pssm-ID: 340423 [Multi-domain]  Cd Length: 125  Bit Score: 50.59  E-value: 1.53e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489610262 483 WNCEMNVElkvsgDTSIRGEINN--MTQVMNNIITNAIEaYNGKGGKIDLIFSKKGHNLEITVRDYGCGIPESVKSKLFK 560
Cdd:cd16947    1 FQVEINIP-----DRPIYANANTeaLQRILKNLISNAIK-YGSDGKFLGMTLREDEKHVYIDIWDKGKGISETEKDHVFE 74

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 489610262 561 EMVTTKGS-----KGTGIGVYMAySTIKGKFGGTMTIDSKEGKGTSVNITI 606
Cdd:cd16947   75 RLYTLEDSrnsakQGNGLGLTIT-KRLAESMGGSIYVNSKPYEKTVFTVTL 124
PRK11100 PRK11100
sensory histidine kinase CreC; Provisional
 488-609 1.76e-07

sensory histidine kinase CreC; Provisional


Pssm-ID: 236846 [Multi-domain]  Cd Length: 475  Bit Score: 54.08  E-value: 1.76e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489610262 488 NVELKVSG-DTSIRGEINNMTQVMNNIITNAIEaYNGKGGKIDLIFSKKGHNLEITVRDYGCGIPESVKSKLFKEMVTT- 565
Cdd:PRK11100 350 GITLRLRPdDARVLGDPFLLRQALGNLLDNAID-FSPEGGTITLSAEVDGEQVALSVEDQGPGIPDYALPRIFERFYSLp 428

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 489610262 566 ---KGSKGTGIGVYMAYSTIKgKFGGTMTIDSKEGKGTSVNITIPLK 609
Cdd:PRK11100 429 rpaNGRKSTGLGLAFVREVAR-LHGGEVTLRNRPEGGVLATLTLPRH 474
HATPase_YpdA-YehU-LytS-like cd16924
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 512-607 2.81e-07

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli YpdA, YehU, Bacillus subtilis LytS, and some hybrid sensor histidine kinases; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis LytS, a HK of the two-component system (TCS) LytS-LytR needed for growth on pyruvate, and Staphylococcus aureus LytS-LytR TCS involved in the adaptation of S. aureus to cationic antimicrobial peptides. It also includes the HATPase domains of Escherichia coli YpdA and YehU, HKs of YpdA-YpdB and YehU-YehTCSs, which are involved together in a nutrient sensing regulatory network. Proteins having this HATPase domain also contain a histidine kinase domain (His-kinase), some having accessory sensor domain(s) such as Cache, HAMP or GAF; some are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.


Pssm-ID: 340401 [Multi-domain]  Cd Length: 103  Bit Score: 48.98  E-value: 2.81e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489610262 512 NIITNAIEAYNGKGgKIDLIFSKKGHNLEITVRDYGCGIPESVKSKLFKemvttKGSKGTGIGVYMAYSTIKGKFGG--T 589
Cdd:cd16924   12 NAIQHGLSPLTDKG-VVTISALKEDNHVMIEVEDNGRGIDPKVLNILGK-----KPKEGNGIGLYNVHQRLILLFGEdyG 85

                         90
                 ....*....|....*...
gi 489610262 590 MTIDSKEGKGTSVNITIP 607
Cdd:cd16924   86 IHIASEPDKGTRITFTIP 103
PRK11466 PRK11466
hybrid sensory histidine kinase TorS; Provisional
 446-616 4.73e-07

hybrid sensory histidine kinase TorS; Provisional


Pssm-ID: 236914 [Multi-domain]  Cd Length: 914  Bit Score: 52.99  E-value: 4.73e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489610262 446 SAVK--GQAVNFNDSTdgiFTVDELIKNVKLLMSHEIKFWNCEMNVELKVSGDTSIRGEINNMTQVMNNIITNAIEaYNG 523
Cdd:PRK11466 503 SAIEagGKNVSVSDEP---FEPRPLLESTLQLMSGRVKGRPIRLATDIADDLPTALMGDPRRIRQVITNLLSNALR-FTD 578

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489610262 524 KGGKIDLIFSKKGHNLeITVRDYGCGIPESVKSKLFKEMVTTKGSK-GTGIGVYMAySTIKGKFGGTMTIDSKEGKGTSV 602
Cdd:PRK11466 579 EGSIVLRSRTDGEQWL-VEVEDSGCGIDPAKLAEIFQPFVQVSGKRgGTGLGLTIS-SRLAQAMGGELSATSTPEVGSCF 656

                        170
                 ....*....|....
gi 489610262 603 NITIPLKDKDFTPP 616
Cdd:PRK11466 657 CLRLPLRVATAPVP 670
HATPase_EL346-LOV-HK-like cd16951
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 491-607 7.62e-07

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Erythrobacter litoralis blue light-activated histidine kinase 2; This domain family includes the histidine kinase-like ATPase (HATPase) domain of blue light-activated histidine kinase 2 of Erythrobacter litoralis (EL346). Signaling commonly occurs within HK dimers, however EL346 functions as a monomer. Also included in this family are the HATPase domains of ethanolamine utilization sensory transduction histidine kinase (EutW), whereby regulation of ethanolamine, a carbon and nitrogen source for gut bacteria, results in autophosphorylation and subsequent phosphoryl transfer to a response regulator (EutV) containing an RNA-binding domain. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have an accessory PAS sensor domain, while some have an N-terminal histidine kinase domain.


Pssm-ID: 340427 [Multi-domain]  Cd Length: 131  Bit Score: 48.57  E-value: 7.62e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489610262 491 LKVSGDTSIRgeinnMTQVMNNIITNAIE-AYNGK-GGKIDLIFSKKGHNLEITVRDYGCGIPESVKSklfkemvTTKGS 568
Cdd:cd16951   30 GPVSSEVATA-----IGLVVNELLQNALKhAFSDReGGTITIRSVVDGDYLRITVIDDGVGLPQDEDW-------PNKGS 97

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 489610262 569 kgtgIGVYMAYSTIKGKFGGTMTIDSKEgKGTSVNITIP 607
Cdd:cd16951   98 ----LGLQIVRSLVEGELKAFLEVQSAE-NGTRVNIDIP 131
HATPase_BasS-like cd16940
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 508-604 1.55e-06

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BasS HK of the BasS-BasR two-component regulatory system (TCS). Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some contain a HAMP sensory domain, while some an N-terminal two-component sensor kinase domain.


Pssm-ID: 340417 [Multi-domain]  Cd Length: 113  Bit Score: 47.02  E-value: 1.55e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489610262 508 QVMNNIITNAIEaYNGKGGKIDLIFSKKGHNLeITVRDYGCGIPESVKSKLFKEMVTTKGS--KGTGIGVYMAySTIKGK 585
Cdd:cd16940   16 LLLRNLVDNAVR-YSPQGSRVEIKLSADDGAV-IRVEDNGPGIDEEELEALFERFYRSDGQnyGGSGLGLSIV-KRIVEL 92

                         90
                 ....*....|....*....
gi 489610262 586 FGGTMTIDSKEGKGTSVNI 604
Cdd:cd16940   93 HGGQIFLGNAQGGGLEAWV 111
HATPase_CpxA-like cd16949
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 508-608 1.86e-06

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CpxA; This family includes the histidine kinase-like ATPase (HATPase) domains of two-component sensor histidine kinase (HKs) similar to Escherichia coli CpxA, HK of the CpxA-CpxR two-component regulatory system (TCS) which may function in acid stress and in cell wall stability. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a CpxA family periplasmic domain.


Pssm-ID: 340425 [Multi-domain]  Cd Length: 104  Bit Score: 46.55  E-value: 1.86e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489610262 508 QVMNNIITNAIEAYNGKggkIDLIFSKKGHNLEITVRDYGCGIPESVKSKLFK-----EMVTTKGSKGTGIGVYMAYSTI 582
Cdd:cd16949    3 RALENVLRNALRYSPSK---ILLDISQDGDQWTITITDDGPGVPEDQLEQIFLpfyrvDSARDRESGGTGLGLAIAERAI 79

                         90       100
                 ....*....|....*....|....*.
gi 489610262 583 KgKFGGTMTIDSKEGKGTSVNITIPL 608
Cdd:cd16949   80 E-QHGGKIKASNRKPGGLRVRIWLPA 104
PRK11091 PRK11091
aerobic respiration control sensor protein ArcB; Provisional
 508-608 2.09e-06

aerobic respiration control sensor protein ArcB; Provisional


Pssm-ID: 236842 [Multi-domain]  Cd Length: 779  Bit Score: 50.71  E-value: 2.09e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489610262 508 QVMNNIITNAIEaYNGKGGKIDLIFSKKGHNLEITVRDYGCGIPESVKSKLF------KEMVTTKGSKGTGIGVYMAYST 581
Cdd:PRK11091 401 QILWNLISNAVK-FTQQGGVTVRVRYEEGDMLTFEVEDSGIGIPEDELDKIFamyyqvKDSHGGKPATGTGIGLAVSKRL 479

                         90       100
                 ....*....|....*....|....*..
gi 489610262 582 IKGkFGGTMTIDSKEGKGTSVNITIPL 608
Cdd:PRK11091 480 AQA-MGGDITVTSEEGKGSCFTLTIHA 505
Cache_3-Cache_2 pfam17201
Cache 3/Cache 2 fusion domain; The Cache_3-Cache_2 domain likely originated as a fusion of ...
 203-326 4.18e-06

Cache 3/Cache 2 fusion domain; The Cache_3-Cache_2 domain likely originated as a fusion of sCache_3 and sCache_2 domains.


Pssm-ID: 465378 [Multi-domain]  Cd Length: 298  Bit Score: 48.88  E-value: 4.18e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489610262  203 IKGENNEEIGMLILNVKESYIY----SLISEIKLPDEGQLYIVG----KDGNYVMNPFNRLQNG-KVDYVKYELYIEEIL 273
Cdd:pfam17201 166 IRDADGKVIGILYVGVPQDEALaslrKAIKKVKIGKTGYLYVLDgkgdQKGKFIVHPTLEGKNIlDAKDADGEPFVKKLL 245

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 489610262  274 KKKNG----TFIKKIDGRDYLLAFQTIDsingiELGWTVFGMTPVDIITSGIESTQD 326
Cdd:pfam17201 246 QKKVGsleyPWKADAAGRDKLAAFTYFE-----PWDWVIVASVYEDEFLAATNRLLN 297
HATPase_CreC-like cd16945
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 508-599 4.29e-06

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CreC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli CreC of the CreC-CreB two-component regulatory system (TCS) involved in catabolic regulation. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and accessory sensory domain(s) such as HAMP, CACHE or PAS.


Pssm-ID: 340421 [Multi-domain]  Cd Length: 106  Bit Score: 45.91  E-value: 4.29e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489610262 508 QVMNNIITNAIeAYNGKGGKIDLIFSKKGHNLEITVRDYGCGIPESVKSKLFKEMVT----TKGSKGTGIGVYMAySTIK 583
Cdd:cd16945    7 QAINNLLDNAI-DFSPEGGLIALQLEADTEGIELLVFDEGSGIPDYALNRVFERFYSlprpHSGQKSTGLGLAFV-QEVA 84

                         90
                 ....*....|....*.
gi 489610262 584 GKFGGTMTIDSKEGKG 599
Cdd:cd16945   85 QLHGGRITLRNRPDGV 100
glnL PRK11073
nitrogen regulation protein NR(II);
508-585 5.86e-06

nitrogen regulation protein NR(II);


Pssm-ID: 182947 [Multi-domain]  Cd Length: 348  Bit Score: 48.92  E-value: 5.86e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489610262 508 QVMNNIITNAIEAYNGKGGKIDL---------IFSKKgHNL--EITVRDYGCGIPESVKSKLFKEMVTTKgSKGTGIGVY 576
Cdd:PRK11073 240 QVLLNIVRNALQALGPEGGTITLrtrtafqltLHGER-YRLaaRIDIEDNGPGIPPHLQDTLFYPMVSGR-EGGTGLGLS 317

                         90
                 ....*....|..
gi 489610262 577 MAYSTI---KGK 585
Cdd:PRK11073 318 IARNLIdqhSGK 329
PRK09303 PRK09303
histidine kinase;
506-607 6.37e-06

histidine kinase;


Pssm-ID: 236462 [Multi-domain]  Cd Length: 380  Bit Score: 48.79  E-value: 6.37e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489610262 506 MTQVMNNIITNAIEaYNGKGGKIDL-IFSKKGHNLEITVRDYGCGIPESVKSKLFKEMVTTKGSKGT---GIGVYMAYST 581
Cdd:PRK09303 273 IRQVLLNLLDNAIK-YTPEGGTITLsMLHRTTQKVQVSICDTGPGIPEEEQERIFEDRVRLPRDEGTegyGIGLSVCRRI 351

                         90       100
                 ....*....|....*....|....*.
gi 489610262 582 IKGKfGGTMTIDSKEGKGTSVNITIP 607
Cdd:PRK09303 352 VRVH-YGQIWVDSEPGQGSCFHFTLP 376
HATPase_TutC-TodS-like cd16925
Histidine kinase-like ATPase domain of hybrid sensor histidine kinases similar to Pseudomonas ...
 506-607 6.78e-06

Histidine kinase-like ATPase domain of hybrid sensor histidine kinases similar to Pseudomonas putida TodS and Thauera aromatica TutC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinase (HKs) such Pseudomonas putida TodS HK of the TodS-TodT two-component regulatory system (TCS) which controls the expression of a toluene degradation pathway. Thauera aromatica TutC may be part of a TCS that is involved in anaerobic toluene metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), PAS sensor domain(s) and a REC domain.


Pssm-ID: 340402 [Multi-domain]  Cd Length: 110  Bit Score: 45.18  E-value: 6.78e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489610262 506 MTQVMNNIITNAIEaYNGKGGKIDLIFSKKGHN-LEITVRDYGCGIPESVKSKLFKEM-----VTTKGSKGTGIGVymay 579
Cdd:cd16925    5 YERVVLNLLSNAFK-FTPDGGRIRCILEKFRLNrFLLTVSDSGPGIPPNLREEIFERFrqgdgSSTRAHGGTGLGL---- 79

                         90       100       110
                 ....*....|....*....|....*....|..
gi 489610262 580 sTIKGKF----GGTMTIDSKEGKGTSVNITIP 607
Cdd:cd16925   80 -SIVKEFvelhGGTVTVSDAPGGGALFQVELP 110
PRK09959 PRK09959
acid-sensing system histidine kinase EvgS;
508-609 1.10e-05

acid-sensing system histidine kinase EvgS;


Pssm-ID: 182169 [Multi-domain]  Cd Length: 1197  Bit Score: 48.58  E-value: 1.10e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489610262  508 QVMNNIITNAIEAYNGKGGKI--DLIFSKKGHN-LEITVRDYGCGIPESVKSKLFKEMVTTKGSK---GTGIGVYMAYST 581
Cdd:PRK09959  831 QVLSNLLSNALKFTTEGAVKIttSLGHIDDNHAvIKMTIMDSGSGLSQEEQQQLFKRYSQTSAGRqqtGSGLGLMICKEL 910

                          90       100
                  ....*....|....*....|....*...
gi 489610262  582 IKgKFGGTMTIDSKEGKGTSVNITIPLK 609
Cdd:PRK09959  911 IK-NMQGDLSLESHPGIGTTFTITIPVE 937
HATPase_BaeS-like cd16946
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 508-607 1.10e-05

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BaeS HK of the BaeS/BaeR two-component regulatory system (TCS), which responds to envelope stress. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensory domain.


Pssm-ID: 340422 [Multi-domain]  Cd Length: 109  Bit Score: 44.76  E-value: 1.10e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489610262 508 QVMNNIITNAIEaYNGKGGKIDLIFSKKGHNLEITVRDYGCGIPESVKSKLFKEMVTTKGSK-----GTGIGVYMAYSTI 582
Cdd:cd16946    7 QLFVNLLENSLR-YTDTGGKLRIRAAQTPQEVRLDVEDSAPGVSDDQLARLFERFYRVESSRnrasgGSGLGLAICHNIA 85

                         90       100
                 ....*....|....*....|....*
gi 489610262 583 KGkFGGTMTIDSKEGKGTSVNITIP 607
Cdd:cd16946   86 LA-HGGTISAEHSPLGGLRLVLTLP 109
COG4192 COG4192
Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal ...
 491-602 1.21e-05

Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal transduction mechanisms];


Pssm-ID: 443346 [Multi-domain]  Cd Length: 640  Bit Score: 48.14  E-value: 1.21e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489610262 491 LKVSGDTSIRGEINNMTQVMNNIITNAIEAYNGKgGKIDLIFSKKGHNLEITVRDYGCGIPesVKSKLFKEMVTTKgSKG 570
Cdd:COG4192  529 LHIPDDLMVQGDQVLLEQVLVNLLVNALDAVATQ-PQISVDLLSNAENLRVAISDNGNGWP--LVDKLFTPFTTTK-EVG 604

                         90       100       110
                 ....*....|....*....|....*....|..
gi 489610262 571 TGIGVYMAYStIKGKFGGTMTIDSKEGKGTSV 602
Cdd:COG4192  605 LGLGLSICRS-IMQQFGGDLYLASTLERGAMV 635
HATPase_EnvZ-like cd16950
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 506-607 9.58e-05

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli EnvZ and Pseudomonas aeruginosa BfmS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli EnvZ of the EnvZ-OmpR two-component regulatory system (TCS), which functions in osmoregulation. It also contains the HATPase domain of Pseudomonas aeruginosa BfmS, the HK of the BfmSR TCS, which functions in the regulation of the rhl quorum-sensing system and bacterial virulence in P. aeruginosa. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a periplasmic domain.


Pssm-ID: 340426 [Multi-domain]  Cd Length: 101  Bit Score: 41.67  E-value: 9.58e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489610262 506 MTQVMNNIITNAIeayNGKGGKIDLIFSKKGHNLEITVRDYGCGIPESVKSKLFKEMV---TTKGSKGTGIGVYMAYSTI 582
Cdd:cd16950    1 LKRVLSNLVDNAL---RYGGGWVEVSSDGEGNRTRIQVLDNGPGIAPEEVDELFQPFYrgdNARGTSGTGLGLAIVQRIS 77

                         90       100
                 ....*....|....*....|....*
gi 489610262 583 KgKFGGTMTIDSKEGKGTSVNITIP 607
Cdd:cd16950   78 D-AHGGSLTLANRAGGGLCARIELP 101
PRK10841 PRK10841
two-component system sensor histidine kinase RcsC;
498-616 1.08e-04

two-component system sensor histidine kinase RcsC;


Pssm-ID: 182772 [Multi-domain]  Cd Length: 924  Bit Score: 45.35  E-value: 1.08e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489610262 498 SIRGEINNMTQVMNNIITNAIEaYNGKGGKIDLIFSKKGHnLEITVRDYGCGIPESVKSKLFKEMV-----TTKGSKGTG 572
Cdd:PRK10841 555 ALNGDPMRLQQVISNLLSNAIK-FTDTGCIVLHVRVDGDY-LSFRVRDTGVGIPAKEVVRLFDPFFqvgtgVQRNFQGTG 632

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 489610262 573 IGVYMAYSTIKgKFGGTMTIDSKEGKGTSVNITIPLKDKDFTPP 616
Cdd:PRK10841 633 LGLAICEKLIN-MMDGDISVDSEPGMGSQFTIRIPLYGAQYPQK 675
PRK11107 PRK11107
hybrid sensory histidine kinase BarA; Provisional
 508-608 2.11e-04

hybrid sensory histidine kinase BarA; Provisional


Pssm-ID: 236848 [Multi-domain]  Cd Length: 919  Bit Score: 44.45  E-value: 2.11e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489610262 508 QVMNNIITNAIeayngK---GGKIDLIFSKKGH-----NLEITVRDYGCGIPESVKSKLFKEMVTTKGS-----KGTGIG 574
Cdd:PRK11107 411 QIITNLVGNAI-----KfteSGNIDILVELRALsntkvQLEVQIRDTGIGISERQQSQLFQAFRQADASisrrhGGTGLG 485

                         90       100       110
                 ....*....|....*....|....*....|....
gi 489610262 575 VYMAYSTIKgKFGGTMTIDSKEGKGTSVNITIPL 608
Cdd:PRK11107 486 LVITQKLVN-EMGGDISFHSQPNRGSTFWFHLPL 518
PRK10490 PRK10490
sensor protein KdpD; Provisional
 506-616 9.61e-04

sensor protein KdpD; Provisional


Pssm-ID: 236701 [Multi-domain]  Cd Length: 895  Bit Score: 42.33  E-value: 9.61e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489610262 506 MTQVMNNIITNAIEaYNGKGGKIDLIFSKKGHNLEITVRDYGCGIPESVKSKLFKEMvtTKGSK-----GTGIGVYMAyS 580
Cdd:PRK10490 779 FERVLINLLENAVK-YAGAQAEIGIDAHVEGERLQLDVWDNGPGIPPGQEQLIFDKF--ARGNKesaipGVGLGLAIC-R 854

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 489610262 581 TIKGKFGGTMTIDSKEGKGTSVNITIPLKdkdfTPP 616
Cdd:PRK10490 855 AIVEVHGGTIWAENRPEGGACFRVTLPLE----TPP 886
RsbW COG2172
Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms];
513-551 9.98e-04

Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms];


Pssm-ID: 441775 [Multi-domain]  Cd Length: 127  Bit Score: 39.51  E-value: 9.98e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|.
gi 489610262 513 IITNAIE-AYNGK-GGKIDLIFSKKGHNLEITVRDYGCGIP 551
Cdd:COG2172   42 AVTNAVRhAYGGDpDGPVEVELELDPDGLEIEVRDEGPGFD 82
cpxA PRK09470
envelope stress sensor histidine kinase CpxA;
487-608 1.24e-03

envelope stress sensor histidine kinase CpxA;


Pssm-ID: 236532 [Multi-domain]  Cd Length: 461  Bit Score: 41.84  E-value: 1.24e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489610262 487 MNVELKVS---GDTSIRGEINNMTQVMNNIITNAIeaYNGKGgKIDLIFSKKGHNLEITVRDYGCGIPESVKSKLFK--- 560
Cdd:PRK09470 332 MGKSLTVSappGPWPINGNPNALASALENIVRNAL--RYSHT-KIEVAFSVDKDGLTITVDDDGPGVPEEEREQIFRpfy 408

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 489610262 561 --EMVTTKGSKGTGIGVYMAYSTIKGKFGGTMTIDSKEGkGTSVNITIPL 608
Cdd:PRK09470 409 rvDEARDRESGGTGLGLAIVENAIQQHRGWVKAEDSPLG-GLRLTIWLPL 457
envZ PRK09467
osmolarity sensor protein; Provisional
 506-610 2.87e-03

osmolarity sensor protein; Provisional


Pssm-ID: 236531 [Multi-domain]  Cd Length: 435  Bit Score: 40.28  E-value: 2.87e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489610262 506 MTQVMNNIITNAIEAYNGKggkIDLIFSKKGHNLEITVRDYGCGIPESVKSKLFKEMV---TTKGSKGTGIGVymaySTI 582
Cdd:PRK09467 332 IKRALANLVVNAARYGNGW---IKVSSGTEGKRAWFQVEDDGPGIPPEQLKHLFQPFTrgdSARGSSGTGLGL----AIV 404

                         90       100       110
                 ....*....|....*....|....*....|.
gi 489610262 583 K---GKFGGTMTIDSKEGKGTSVNITIPLKD 610
Cdd:PRK09467 405 KrivDQHNGKVELGNSEEGGLSARAWLPLTT 435
HATPase_UhpB-NarQ-NarX-like cd16917
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 514-607 4.69e-03

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli UhpB, NarQ and NarX, and Bacillus subtilis YdfH, YhcY and YfiJ; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Escherichia coli UhpB, a HK of the UhpB-UhpA TCS, NarQ and NarX, HKs of the NarQ-NarP and NarX-NarL TCSs, respectively, and Bacillus YdfH, YhcY and YfiJ HKs, of the YdfH-YdfI, YhcY-YhcZ and YfiJ-YfiK TCSs, respectively. In addition, it includes Bacillus YxjM, ComP, LiaS and DesK, HKs of the YxjM-YxjML, ComP-ComA, LiaS-LiaR, DesR-DesK TCSs, respectively. Proteins having this HATPase domain have a histidine kinase dimerization and phosphoacceptor domain; some have accessory domains such as GAF, HAMP, PAS and MASE sensor domains.


Pssm-ID: 340394 [Multi-domain]  Cd Length: 87  Bit Score: 36.38  E-value: 4.69e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489610262 514 ITNAIEayNGKGGKIDLIFSKKGHNLEITVRDYGCGIPEsvksklfkemVTTKGSKGTGIgvymaystiKG------KFG 587
Cdd:cd16917    9 LTNALK--HAGASRVRVTLSYTADELTLTVVDDGVGFDG----------PAPPGGGGFGL---------LGmreraeLLG 67

                         90       100
                 ....*....|....*....|
gi 489610262 588 GTMTIDSKEGKGTSVNITIP 607
Cdd:cd16917   68 GTLTIGSRPGGGTRVTARLP 87
HATPase_VanS-like cd16923
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 506-607 5.11e-03

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Enterococcus faecium VanS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Enterococcus faecium VanS HK of the VanS-VanR two-component regulatory system (TCS) which activates the transcription of vanH, vanA and vanX vancomycin resistance genes. It also contains Ecoli YedV and PcoS, probable members of YedW-YedV TCS and PcoS-PcoR TCS, repectively. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); most also have a HAMP sensor domain.


Pssm-ID: 340400 [Multi-domain]  Cd Length: 102  Bit Score: 36.98  E-value: 5.11e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489610262 506 MTQVMNNIITNAIeAYNGKGGKIDLIFSKKGHNLEITVRDYGCGIPESVKSKLFKEMV---TTKGSKGTGIGVYMAYSTI 582
Cdd:cd16923    1 LQRVFSNLLSNAI-KYSPENTRIYITSFLTDDVVNIMFKNPSSHPLDFKLEKLFERFYrgdNSRNTEGAGLGLSIAKAII 79

                         90       100
                 ....*....|....*....|....*
gi 489610262 583 KGKfGGTMTIDSkEGKGTSVNITIP 607
Cdd:cd16923   80 ELH-GGSASAEY-DDNHDLFKVRLP 102
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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