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Conserved domains on  [gi|489515605|ref|WP_003420440|]
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MULTISPECIES: wax ester/triacylglycerol synthase family O-acyltransferase [Mycobacterium]

Protein Classification

WS/DGAT/MGAT family O-acyltransferase( domain architecture ID 11496208)

WS/DGAT/MGAT family O-acyltransferase catalyzes the terminal and only committed step in triacylglycerol synthesis by using diacylglycerol and fatty acyl CoA as substrates; such as Acinetobacter baylyi O-acyltransferase WSD, a bifunctional wax ester synthase/diacylglycerol acyltransferase

EC:  2.3.1.-
Gene Ontology:  GO:0008374|GO:0045017
PubMed:  12502715|15687201

Graphical summary

 Zoom to residue level

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List of domain hits

Name Accession Description Interval E-value
acyl_WS_DGAT TIGR02946
acyltransferase, WS/DGAT/MGAT; This bacteria-specific protein family includes a characterized, ...
4-452 3.58e-160

acyltransferase, WS/DGAT/MGAT; This bacteria-specific protein family includes a characterized, homodimeric, broad specificity acyltransferase from Acinetobacter sp. strain ADP1, active as wax ester synthase, as acyl coenzyme A:diacylglycerol acyltransferase, and as acyl-CoA:monoacylglycerol acyltransferase. [Unknown function, Enzymes of unknown specificity]


:

Pssm-ID: 274360 [Multi-domain]  Cd Length: 446  Bit Score: 459.85  E-value: 3.58e-160
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489515605    4 MMPNDSMFLFIESREHPMHVGGLSLFEPPQGAgPEFVREFTERLvandEFQPMFRKHPATIGGGIARVAWAYDDDIDIDY 83
Cdd:TIGR02946   1 LSPVDAAFLRLETPTRPMHIGALAVFEGPLSF-EALRALLESRL----PLAPRFRQRLREVPLGLGHPYWVEDPDFDLDY 75
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489515605   84 HVRRSALPSPGRVRDLLELTSRLHTSLLDRHRPLWELHVVEGLNDGRFAMYTKMHHALIDGVSAMKLAQRTLSADPDDAE 163
Cdd:TIGR02946  76 HVRRVALPAPGTRRELLELVGRLMSTPLDRSRPLWEMHLIEGLAGGRFAVLTKVHHALADGVAGLRLLARLLDDDPDPPP 155
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489515605  164 VRAIWNLPPRPRTRPPSDGssLLDALFKMAGSVVGLAPSTLKLARAALL----EQQLTLPFAAPHSMFNVKVGGARRCAA 239
Cdd:TIGR02946 156 LPAPPPPPQPSTRGLLSGA--LSGLPSALLRRVASTAPGVVRAAGRAVEgvarSARPALPFTAPPTPLNGPISRKRRFAA 233
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489515605  240 QSWSLDRIKSVKQAAGVTVNDAVLAMCAGALRYYLIERNALPDRPLIAMVPVSLRSKEDADAGGNLVGSVLCNLATHVDD 319
Cdd:TIGR02946 234 QSLPLADVKAVAKAFGVTINDVVLAAVAGALRRYLEERGELPDDPLVAMVPVSLRPMEDDSEGGNQVSAVLVPLPTGIAD 313
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489515605  320 PAQRIQTISASMDGNKKVLSELPQLQVLALSALNMAPLTLAGVPGFLSAVPPPFNIVISNVPGPVDPLYYGTARLDGSYP 399
Cdd:TIGR02946 314 PVERLSAIHASMTRAKESGQAMGANALLALSGLLPAPLLRLALRALARKAQRLFNLVISNVPGPREPLYLAGAKLDELYP 393
                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|...
gi 489515605  400 LSNIPDGQALNITLVNNAGNLDFGLVGCRRSVPHLQRLLAHLESSLKDLEQAV 452
Cdd:TIGR02946 394 LSPLLDGQGLNITVTSYNGQLDFGLLADRDAVPDPQELADALEAALEELEAAA 446
 
Name Accession Description Interval E-value
acyl_WS_DGAT TIGR02946
acyltransferase, WS/DGAT/MGAT; This bacteria-specific protein family includes a characterized, ...
4-452 3.58e-160

acyltransferase, WS/DGAT/MGAT; This bacteria-specific protein family includes a characterized, homodimeric, broad specificity acyltransferase from Acinetobacter sp. strain ADP1, active as wax ester synthase, as acyl coenzyme A:diacylglycerol acyltransferase, and as acyl-CoA:monoacylglycerol acyltransferase. [Unknown function, Enzymes of unknown specificity]


Pssm-ID: 274360 [Multi-domain]  Cd Length: 446  Bit Score: 459.85  E-value: 3.58e-160
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489515605    4 MMPNDSMFLFIESREHPMHVGGLSLFEPPQGAgPEFVREFTERLvandEFQPMFRKHPATIGGGIARVAWAYDDDIDIDY 83
Cdd:TIGR02946   1 LSPVDAAFLRLETPTRPMHIGALAVFEGPLSF-EALRALLESRL----PLAPRFRQRLREVPLGLGHPYWVEDPDFDLDY 75
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489515605   84 HVRRSALPSPGRVRDLLELTSRLHTSLLDRHRPLWELHVVEGLNDGRFAMYTKMHHALIDGVSAMKLAQRTLSADPDDAE 163
Cdd:TIGR02946  76 HVRRVALPAPGTRRELLELVGRLMSTPLDRSRPLWEMHLIEGLAGGRFAVLTKVHHALADGVAGLRLLARLLDDDPDPPP 155
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489515605  164 VRAIWNLPPRPRTRPPSDGssLLDALFKMAGSVVGLAPSTLKLARAALL----EQQLTLPFAAPHSMFNVKVGGARRCAA 239
Cdd:TIGR02946 156 LPAPPPPPQPSTRGLLSGA--LSGLPSALLRRVASTAPGVVRAAGRAVEgvarSARPALPFTAPPTPLNGPISRKRRFAA 233
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489515605  240 QSWSLDRIKSVKQAAGVTVNDAVLAMCAGALRYYLIERNALPDRPLIAMVPVSLRSKEDADAGGNLVGSVLCNLATHVDD 319
Cdd:TIGR02946 234 QSLPLADVKAVAKAFGVTINDVVLAAVAGALRRYLEERGELPDDPLVAMVPVSLRPMEDDSEGGNQVSAVLVPLPTGIAD 313
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489515605  320 PAQRIQTISASMDGNKKVLSELPQLQVLALSALNMAPLTLAGVPGFLSAVPPPFNIVISNVPGPVDPLYYGTARLDGSYP 399
Cdd:TIGR02946 314 PVERLSAIHASMTRAKESGQAMGANALLALSGLLPAPLLRLALRALARKAQRLFNLVISNVPGPREPLYLAGAKLDELYP 393
                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|...
gi 489515605  400 LSNIPDGQALNITLVNNAGNLDFGLVGCRRSVPHLQRLLAHLESSLKDLEQAV 452
Cdd:TIGR02946 394 LSPLLDGQGLNITVTSYNGQLDFGLLADRDAVPDPQELADALEAALEELEAAA 446
WES_acyltransf pfam03007
Wax ester synthase-like Acyl-CoA acyltransferase domain; This domain is found in wax ester ...
6-262 1.22e-102

Wax ester synthase-like Acyl-CoA acyltransferase domain; This domain is found in wax ester synthase genes. In these proteins this domain catalyzes the CoA dependent acyltransferase reaction with fatty alcohols to form wax esters.


Pssm-ID: 281060 [Multi-domain]  Cd Length: 261  Bit Score: 306.61  E-value: 1.22e-102
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489515605    6 PNDSMFLFIESREHPMHVGGLSLFEPP-QGAGPEFVREFTERLVANDEFQPMFRKHPATIGGGIARVAWAYDDDIDIDYH 84
Cdd:pfam03007   1 PLDALFLYLETPDRPMHVGALAVFEPPsAGAGPLFWRRFREAIEQRLHRAPRFRQRVVVRPLGLAHPVWVDDPDFDLDYH 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489515605   85 VRRSALPSPGRVRDLLELTSRLHTSLLDRHRPLWELHVVEGLNDGRFAMYTKMHHALIDGVSAMKLAQRTLSADPDDAEV 164
Cdd:pfam03007  81 VRRSALPAPGGRRELHELVSRLHSRPLDRSRPLWEMHVIEGLEGGRFAVLTKVHHALADGVGGLNLLARLLDLDPDPPPR 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489515605  165 RAIWNLPPRPRTRPPSDGS---SLLDALFKMAGSVVGLAPSTLKLARAALLEQQLTLPFAAPHSMFNVKVGGARRCAAQS 241
Cdd:pfam03007 161 PTPPQTPPGDPRTQLRAGGalvGPAAGLGGVAGGVRGVVRSAGRLLERALEARSVALPFAAPHTPFNAPLSRARRFAAQS 240
                         250       260
                  ....*....|....*....|.
gi 489515605  242 WSLDRIKSVKQAAGVTVNDAV 262
Cdd:pfam03007 241 LPLADVKAVAKATGVTINDVV 261
COG4908 COG4908
Uncharacterized conserved protein, contains a NRPS condensation (elongation) domain [General ...
84-152 9.39e-08

Uncharacterized conserved protein, contains a NRPS condensation (elongation) domain [General function prediction only];


Pssm-ID: 443936 [Multi-domain]  Cd Length: 243  Bit Score: 52.73  E-value: 9.39e-08
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489515605  84 HVRRSALPSPGRVRDLLELTSRLHTSLLDR-HRPLWELHVVEgLNDGRFAMYTKMHHALIDGVSAMKLAQ 152
Cdd:COG4908   74 VVDLSALPEPEREAELEELVAEEASRPFDLaRGPLLRAALIR-LGEDEHVLLLTIHHIISDGWSLGILLR 142
 
Name Accession Description Interval E-value
acyl_WS_DGAT TIGR02946
acyltransferase, WS/DGAT/MGAT; This bacteria-specific protein family includes a characterized, ...
4-452 3.58e-160

acyltransferase, WS/DGAT/MGAT; This bacteria-specific protein family includes a characterized, homodimeric, broad specificity acyltransferase from Acinetobacter sp. strain ADP1, active as wax ester synthase, as acyl coenzyme A:diacylglycerol acyltransferase, and as acyl-CoA:monoacylglycerol acyltransferase. [Unknown function, Enzymes of unknown specificity]


Pssm-ID: 274360 [Multi-domain]  Cd Length: 446  Bit Score: 459.85  E-value: 3.58e-160
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489515605    4 MMPNDSMFLFIESREHPMHVGGLSLFEPPQGAgPEFVREFTERLvandEFQPMFRKHPATIGGGIARVAWAYDDDIDIDY 83
Cdd:TIGR02946   1 LSPVDAAFLRLETPTRPMHIGALAVFEGPLSF-EALRALLESRL----PLAPRFRQRLREVPLGLGHPYWVEDPDFDLDY 75
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489515605   84 HVRRSALPSPGRVRDLLELTSRLHTSLLDRHRPLWELHVVEGLNDGRFAMYTKMHHALIDGVSAMKLAQRTLSADPDDAE 163
Cdd:TIGR02946  76 HVRRVALPAPGTRRELLELVGRLMSTPLDRSRPLWEMHLIEGLAGGRFAVLTKVHHALADGVAGLRLLARLLDDDPDPPP 155
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489515605  164 VRAIWNLPPRPRTRPPSDGssLLDALFKMAGSVVGLAPSTLKLARAALL----EQQLTLPFAAPHSMFNVKVGGARRCAA 239
Cdd:TIGR02946 156 LPAPPPPPQPSTRGLLSGA--LSGLPSALLRRVASTAPGVVRAAGRAVEgvarSARPALPFTAPPTPLNGPISRKRRFAA 233
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489515605  240 QSWSLDRIKSVKQAAGVTVNDAVLAMCAGALRYYLIERNALPDRPLIAMVPVSLRSKEDADAGGNLVGSVLCNLATHVDD 319
Cdd:TIGR02946 234 QSLPLADVKAVAKAFGVTINDVVLAAVAGALRRYLEERGELPDDPLVAMVPVSLRPMEDDSEGGNQVSAVLVPLPTGIAD 313
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489515605  320 PAQRIQTISASMDGNKKVLSELPQLQVLALSALNMAPLTLAGVPGFLSAVPPPFNIVISNVPGPVDPLYYGTARLDGSYP 399
Cdd:TIGR02946 314 PVERLSAIHASMTRAKESGQAMGANALLALSGLLPAPLLRLALRALARKAQRLFNLVISNVPGPREPLYLAGAKLDELYP 393
                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|...
gi 489515605  400 LSNIPDGQALNITLVNNAGNLDFGLVGCRRSVPHLQRLLAHLESSLKDLEQAV 452
Cdd:TIGR02946 394 LSPLLDGQGLNITVTSYNGQLDFGLLADRDAVPDPQELADALEAALEELEAAA 446
WES_acyltransf pfam03007
Wax ester synthase-like Acyl-CoA acyltransferase domain; This domain is found in wax ester ...
6-262 1.22e-102

Wax ester synthase-like Acyl-CoA acyltransferase domain; This domain is found in wax ester synthase genes. In these proteins this domain catalyzes the CoA dependent acyltransferase reaction with fatty alcohols to form wax esters.


Pssm-ID: 281060 [Multi-domain]  Cd Length: 261  Bit Score: 306.61  E-value: 1.22e-102
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489515605    6 PNDSMFLFIESREHPMHVGGLSLFEPP-QGAGPEFVREFTERLVANDEFQPMFRKHPATIGGGIARVAWAYDDDIDIDYH 84
Cdd:pfam03007   1 PLDALFLYLETPDRPMHVGALAVFEPPsAGAGPLFWRRFREAIEQRLHRAPRFRQRVVVRPLGLAHPVWVDDPDFDLDYH 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489515605   85 VRRSALPSPGRVRDLLELTSRLHTSLLDRHRPLWELHVVEGLNDGRFAMYTKMHHALIDGVSAMKLAQRTLSADPDDAEV 164
Cdd:pfam03007  81 VRRSALPAPGGRRELHELVSRLHSRPLDRSRPLWEMHVIEGLEGGRFAVLTKVHHALADGVGGLNLLARLLDLDPDPPPR 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489515605  165 RAIWNLPPRPRTRPPSDGS---SLLDALFKMAGSVVGLAPSTLKLARAALLEQQLTLPFAAPHSMFNVKVGGARRCAAQS 241
Cdd:pfam03007 161 PTPPQTPPGDPRTQLRAGGalvGPAAGLGGVAGGVRGVVRSAGRLLERALEARSVALPFAAPHTPFNAPLSRARRFAAQS 240
                         250       260
                  ....*....|....*....|.
gi 489515605  242 WSLDRIKSVKQAAGVTVNDAV 262
Cdd:pfam03007 241 LPLADVKAVAKATGVTINDVV 261
WS_DGAT_C pfam06974
WS/DGAT C-terminal domain; This domain is found at the C-terminus of wax ester synthases (WS) ...
303-449 8.96e-45

WS/DGAT C-terminal domain; This domain is found at the C-terminus of wax ester synthases (WS)/diacylglycerol O-acyltransferases (DGAT). These enzymes are utilized for the in vivo production of biodiesel and other wax esters.


Pssm-ID: 462057  Cd Length: 144  Bit Score: 153.05  E-value: 8.96e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489515605  303 GNLVGSVLCNLATHVDDPAQRIQTISASMDGNKKVLSELPQLQVLALSALNMAPLTLAGVPGFlsavPPPFNIVISNVPG 382
Cdd:pfam06974   2 GNRFGFVLLPLPTDLDDPLERLRKAKASMDRKKRSLEAVLTYALLELLKLFGAKVAAALITRL----LPNTTLVISNVPG 77
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 489515605  383 PVDPLYYGTARLDGSYPLSNIPDGQALNITLVNNAGNLDFGLVGCRRSVPHLQRLLAHLESSLKDLE 449
Cdd:pfam06974  78 PREPLYFAGHPVKYIYPSVPGLPGQALNITIQSYAGKLRIGLAVDRDLIPDPHRLLDDFEEALEELK 144
COG4908 COG4908
Uncharacterized conserved protein, contains a NRPS condensation (elongation) domain [General ...
84-152 9.39e-08

Uncharacterized conserved protein, contains a NRPS condensation (elongation) domain [General function prediction only];


Pssm-ID: 443936 [Multi-domain]  Cd Length: 243  Bit Score: 52.73  E-value: 9.39e-08
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489515605  84 HVRRSALPSPGRVRDLLELTSRLHTSLLDR-HRPLWELHVVEgLNDGRFAMYTKMHHALIDGVSAMKLAQ 152
Cdd:COG4908   74 VVDLSALPEPEREAELEELVAEEASRPFDLaRGPLLRAALIR-LGEDEHVLLLTIHHIISDGWSLGILLR 142
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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