|
Name |
Accession |
Description |
Interval |
E-value |
| dnaE2 |
PRK05672 |
error-prone DNA polymerase; Validated |
54-1091 |
0e+00 |
|
error-prone DNA polymerase; Validated
Pssm-ID: 235553 [Multi-domain] Cd Length: 1046 Bit Score: 1793.27 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489513042 54 SSVAYAELHAHSAYSFLDGASTPEELVEEAARLGLCALALTDHDGLYGAVRFAEAAAELDVRTVFGAELSLGATarterP 133
Cdd:PRK05672 1 MLPPYAELHCHSNFSFLDGASHPEELVERAARLGLRALAITDECGLAGVVRAAEAAKELGLRLVIGAELSLGPD-----P 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489513042 134 DPPGPHLLVLARGPEGYRRLSRQLAAAHLAGGeKGKPRYDFDALTEAAGGHWHILTGCRKGHVRQALSQGGPAAAQRALA 213
Cdd:PRK05672 76 DPGGPHLLVLARDREGYGRLSRLITRARLRAG-KGEYRLDLDDLAEPAGGHWAILTGCRKGFVILALPYGGDAAALAALA 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489513042 214 DLVDRFTPSRVSIELTHHGHPLDDERNAALAGLAPRFGVGIVATTGAHFADPSRGRLAMAMAAIRARRSLDSAAGWLAPL 293
Cdd:PRK05672 155 ALLDAFFADRVWLELTLHGRPDDDRRNARLAALAARAGVPLVATGDVHMHHRSRRRLQDAMTAIRARRSLAEAGGWLAPN 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489513042 294 GGAHLRSGEEMARLFAWCPEAVTAAAELGERCAFGLQLIAPRLPPFDVPDGHTEDSWLRSLVMAGARERYGPPkSAPRAY 373
Cdd:PRK05672 235 GERHLRSGAEMARLFPDYPEALAETVELAERCAFDLDLLAYEYPDEPVPAGHTPASWLRQLTEAGAARRYGPG-IPPKAR 313
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489513042 374 SQIEHELKVIAQLRFPGYFLVVHDITRFCRDNDILCQGRGSAANSAVCYALGVTAVDPVANELLFERFLSPARDGPPDID 453
Cdd:PRK05672 314 AQIEHELALIAELGYEGYFLTVHDIVRFARSQGILCQGRGSAANSAVCYALGITEVDPVQSGLLFERFLSPERDEPPDID 393
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489513042 454 IDIESDQREKVIQYVYHKYGRDYAAQVANVITYRGRSAVRDMARALGFSPGQQDAWSKQVSHWTGQADDVDG-------- 525
Cdd:PRK05672 394 VDFEHDRREEVIQYVYRRYGRDRAAQVANVITYRPRSAVRDVAKALGLSPGQVDAWAKQVSRWSGSADDLQRlrqagldp 473
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489513042 526 ---IPEQVIDLATQIRNLPRHLGIHSGGMVICDRPIADVCPVEWARMANRSVLQWDKDDCAAIGLVKFDLLGLGMLSALH 602
Cdd:PRK05672 474 espIPRRVVELAAQLIGFPRHLSQHSGGFVICDRPLARLVPVENAAMEGRSVIQWDKDDCAAVGLVKVDVLALGMLSALH 553
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489513042 603 YAKDLVAEHKGIEVDLARLDLSEPAVYEMLARADSVGVFQVESRAQMATLPRLKPRVFYDLVVEVALIRPGPIQGGSVHP 682
Cdd:PRK05672 554 RAFDLIAEHRGRRLTLASIPLDDPAVYDMLCRADSVGVFQVESRAQMAMLPRLRPRTFYDLVVEVAIVRPGPIQGGMVHP 633
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489513042 683 YIRRRNGVDPVIYEHPSMAPALRKTLGVPLFQEQLMQLAVDCAGFSAAEADQLRRAMGSKRSTERMRRLRGRFYDGMRAl 762
Cdd:PRK05672 634 YLRRRNGQEPVTYPHPELEKVLERTLGVPLFQEQVMQIAIDAAGFTPGEADQLRRAMAAWRRKGRLERLRERLYDGMLA- 712
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489513042 763 HGAPDEVIDRIYEKLEAFANFGFPESHALSFASLVFYSAWFKLHHPAAFCAALLRAQPMGFYSPQSLVADARRHGVAVHG 842
Cdd:PRK05672 713 RGYTGEFADRIFEQIKGFGEYGFPESHAASFAKLVYASSWLKCHHPAAFCAALLNSQPMGFYSPQQLVQDARRHGVEVLP 792
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489513042 843 PCVNASLAHATCE---NAGTEVRLGLGAVRYLGAELAEKLVAERtANGPFTSLPDLTSRVQLSVPQVEALATAGALGCFG 919
Cdd:PRK05672 793 VDVNASGWDATLEplpDGGPAVRLGLRLVRGLGEEAAERIVAAR-ARGPFTSVEDLARRAGLDRRQLEALADAGALRSLG 871
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489513042 920 MSRREALWAAGAAATGRPDRLPGVGSSSHIPALPGMSELELAAADVWATGVSPDSYPTQFLRADLDAMGVLPAERLGSVS 999
Cdd:PRK05672 872 GDRRQALWAAGAAATERLDLLPGAPASEAAPALPGMSEGELVAADYWTTGLSLDSHPLALLRPRLDARGVVSAAELLDVE 951
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489513042 1000 DGDRVLIAGAVTHRQRPATAQGVTFINLEDETGMVNVLCTPGVWARHRKLAHTAPALLIRGQVQNASGAITVVAERMGRL 1079
Cdd:PRK05672 952 DGRRVRVAGVVTHRQRPGTASGVTFLTLEDETGMVNVVVWPGLWERQRREALGARLLLVRGRVQNAEGVRHLVADRLEDL 1031
|
1050
....*....|....*
gi 489513042 1080 TLAVG---ARSRDFR 1091
Cdd:PRK05672 1032 SPLLGglrTRSRDFH 1046
|
|
| DnaE |
COG0587 |
DNA polymerase III, alpha subunit [Replication, recombination and repair]; |
55-1076 |
0e+00 |
|
DNA polymerase III, alpha subunit [Replication, recombination and repair];
Pssm-ID: 440352 [Multi-domain] Cd Length: 1050 Bit Score: 1352.43 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489513042 55 SVAYAELHAHSAYSFLDGASTPEELVEEAARLGLCALALTDHDGLYGAVRFAEAAAELDVRTVFGAELSLGATARterpD 134
Cdd:COG0587 2 SPSFVHLHVHSEYSLLDGASRPEELVARAAELGMPALAITDHGNLFGAVRFYKAAKKAGIKPIIGCELYVAPGSR----D 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489513042 135 PPGPHLLVLARGPEGYRRLSRQLAAAHLAGGEKGKPRYDFDALTEAAGGHWhILTGCRKGHVRQALSQGGPAAAQRALAD 214
Cdd:COG0587 78 DAGYHLVLLAKNREGYRNLCRLLSRAYLEGFYKGKPRIDLEDLAEHSEGLI-ALSGCLAGEVGQALLAGQYDEAEAALAR 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489513042 215 LVDRFtPSRVSIELTHHGHPLDDERNAALAGLAPRFGVGIVATTGAHFADPSRGRLAMAMAAIRARRSLDSAAGWLAPLG 294
Cdd:COG0587 157 LKDIF-GDRFYLELQRHGLPEDRRVNAALLELARELGLPLVATNDVHYLNPEDAEAHDVLLCIRTGKTLDDPGRRRFANA 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489513042 295 GAHLRSGEEMARLFAWCPEAVTAAAELGERCAFGLQLIAPRLPPFDVPDGHTEDSWLRSLVMAGARERYGPPKSaPRAYS 374
Cdd:COG0587 236 ERYLKSPEEMAELFADLPEALANTLEIAERCNFSLDLGKYQLPKFPVPEGETEEEYLRKLAEEGLERRYPEGIP-EEYRE 314
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489513042 375 QIEHELKVIAQLRFPGYFLVVHDITRFCRDNDI-LCQGRGSAANSAVCYALGVTAVDPVANELLFERFLSPARDGPPDID 453
Cdd:COG0587 315 RLEYELDVIEKMGFPGYFLIVWDFIRWARSNGIpVGPGRGSAAGSLVAYALGITDVDPIRYDLLFERFLNPERVSMPDID 394
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489513042 454 IDIESDQREKVIQYVYHKYGRDYAAQVANVITYRGRSAVRDMARALGFSPGQQDAWSKQVSHWTG--------------Q 519
Cdd:COG0587 395 IDFCHERREEVIQYVYEKYGRDRVAQIATFGTMRARAAIRDVGRVLGLPYGEVDRLAKLIPNDPGitlekaleeepelrE 474
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489513042 520 ADDVDGIPEQVIDLATQIRNLPRHLGIHSGGMVICDRPIADVCPVEWARMANRSVLQWDKDDCAAIGLVKFDLLGLGMLS 599
Cdd:COG0587 475 LYDSDPEVRRLLDLARKLEGLPRHLSTHAGGVVISDDPLTDLVPLERAAMGGRPVTQFDKDDVEALGLLKFDFLGLRTLT 554
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489513042 600 ALHYAKDLVAEHKGIEVDLARLDLSEPAVYEMLARADSVGVFQVESRAQMATLPRLKPRVFYDLVVEVALIRPGPIQGGS 679
Cdd:COG0587 555 VIRDALDLIKENRGIDIDLADIPLDDPKTYELLQRGDTIGVFQLESRGMRSLLKRLKPDCFEDLVALVALYRPGPMQGGM 634
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489513042 680 VHPYIRRRNGVDPVIYEHPSMAPALRKTLGVPLFQEQLMQLAVDCAGFSAAEADQLRRAMGsKRSTERMRRLRGRFYDGM 759
Cdd:COG0587 635 VPPYIRRKHGREPVEYPHPELEPILKETYGVIVYQEQVMQIAQVLAGFSLGEADLLRRAMG-KKKKEEMAKQREKFVEGA 713
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489513042 760 RAlHGAPDEVIDRIYEKLEAFANFGFPESHALSFASLVFYSAWFKLHHPAAFCAALLRAQPMGFYSPQSLVADARRHGVA 839
Cdd:COG0587 714 VA-NGYDEEFAEEIFDQIEKFAGYGFNKSHAAAYALLAYQTAYLKAHYPAEFMAALLNSQPMGFYKPAQYVQEARRHGIE 792
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489513042 840 VHGPCVNASLAHATCEnAGTEVRLGLGAVRYLGAELAEKLVAERTANGPFTSLPDLTSRV---QLSVPQVEALATAGALG 916
Cdd:COG0587 793 VLPPDVNESDWDFTVE-PGGAIRLGLGAIKGVGEAAAEAIVAAREENGPFTSLFDFCRRVdlrKLNKRVLEALIKAGAFD 871
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489513042 917 CFGMSRRE-----------ALWAAGAAATGRPDRLPGVGSSS----HIPALPGMSELELAAADVWATGVSPDSYPTQFLR 981
Cdd:COG0587 872 SLGPNRRQllwaleaaldaAQQAQKDKASGQLSLFGGAGDEEvaepALPELPEWSEKEKLAAEKEALGLYLSGHPLDLYR 951
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489513042 982 ADLDAMGVLPAERLGSVSDGDRVLIAGAVTHRQRPATAQG--VTFINLEDETGMVNVLCTPGVWARHRKLAHTAPALLIR 1059
Cdd:COG0587 952 EELRRLGVTPAADLAELRDGRRVRVAGLVTSRQRPGTKKGkrMAFVTLEDETGSIEVVVFPEVYERYRRLLLEDRLLLVR 1031
|
1050
....*....|....*..
gi 489513042 1060 GQVQNASGAITVVAERM 1076
Cdd:COG0587 1032 GKVQRRDGVVHLIAERI 1048
|
|
| dnaE |
PRK05673 |
DNA polymerase III subunit alpha; Validated |
61-1091 |
0e+00 |
|
DNA polymerase III subunit alpha; Validated
Pssm-ID: 235554 [Multi-domain] Cd Length: 1135 Bit Score: 704.56 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489513042 61 LHAHSAYSFLDGASTPEELVEEAARLGLCALALTDHDGLYGAVRFAEAAAELDVRTVFGAELSL--GATARTERPDPPgP 138
Cdd:PRK05673 5 LHVHSEYSLLDGAAKIKPLVKKAAELGMPAVALTDHGNLFGAVEFYKAAKGAGIKPIIGCEAYVapEKKDDVSGGGAY-T 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489513042 139 HLLVLARGPEGYRRLSRQLAAAHLAGGEKGKPRYDFDALTEAAGGhwhI--LTGCRKGHVRQALSQGGPAAAQRALADLV 216
Cdd:PRK05673 84 HLTLLAKNETGYRNLFKLSSRAYLEGQYGYKPRIDREWLAEHSEG---LiaLSGCPSGEVGTALLAGQYDEAEEAAAEYQ 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489513042 217 DRFtPSRVSIELTHHGHPLDDERNAALAGLAPRFGVGIVAT---------------------TGAHFADPSRGRLAMAma 275
Cdd:PRK05673 161 EIF-GDRFYLELMRHGLPIERRVEHALLELAKELGLPLVATndvhyltpedaeaheallciaEGKTLDDPDRFRFYSP-- 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489513042 276 airarrsldsaagwlaplgGAHLRSGEEMARLFAWCPEAVTAAAELGERCAFGLQLIAPRLPPFDVPDGHTEDSWLRSLV 355
Cdd:PRK05673 238 -------------------EQYLKSAEEMRELFADLPEALDNTVEIAERCNVEVRLGKPFLPRFPTPDGETEEDYLRKEA 298
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489513042 356 MAGARERY---GPPKSAPRAYSQIEHELKVIAQLRFPGYFLVVHDITRFCRDNDILC-QGRGSAANSAVCYALGVTAVDP 431
Cdd:PRK05673 299 KEGLEERLaflFPDEERPEYVERLEYELDVIIQMGFPGYFLIVADFIQWAKDNGIPVgPGRGSGAGSLVAYALGITDLDP 378
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489513042 432 VANELLFERFLSPARDGPPDIDIDIESDQREKVIQYVYHKYGRDyaaQVANVITYrG----RSAVRDMARALGFSPGQQD 507
Cdd:PRK05673 379 LRFGLLFERFLNPERVSMPDFDIDFCQDRRDEVIRYVAEKYGRD---AVAQIITF-GtmkaKAVIRDVGRVLGMPYGFVD 454
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489513042 508 AWSKQVShwtgqaDDVdGIP---------------------EQVIDLATQIRNLPRHLGIHSGGMVICDRPIADVCPVeW 566
Cdd:PRK05673 455 RITKLIP------PDP-GITlakayeeepelrelyesdpevKRLIDMARKLEGLTRNAGVHAAGVVISPTPLTDFVPL-Y 526
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489513042 567 ARmaNRS---VLQWDKDDCAAIGLVKFDLLGLGMLSALHYAKDLVAEHKGIEVDLARLDLSEPAVYEMLARADSVGVFQV 643
Cdd:PRK05673 527 RD--PDSgmpVTQFDMKDVEAAGLVKFDFLGLRTLTIIDDALKLIKKRRGIDVDLEAIPLDDPKTYELLQRGETLGVFQL 604
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489513042 644 ESRAQMATLPRLKPRVFYDLVVEVALIRPGPIQGGSVHPYIRRRNGVDPVIYEHPSMAPALRKTLGVPLFQEQLMQLAVD 723
Cdd:PRK05673 605 ESRGMRDLLKRLKPDCFEDIIALVALYRPGPMESGMIPNFIDRKHGREEIEYPHPELEPILKETYGIIVYQEQVMQIAQV 684
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489513042 724 CAGFSAAEADQLRRAMGSKRSTErMRRLRGRFYDGMRAlHGAPDEVIDRIYEKLEAFANFGFPESHALSFASLVFYSAWF 803
Cdd:PRK05673 685 LAGYSLGGADLLRRAMGKKKPEE-MAKQREIFVEGAKK-NGIDEEAADAIFDLLEKFAGYGFNKSHAAAYALVSYQTAYL 762
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489513042 804 KLHHPAAFCAALLraqpmgfyspQS----------LVADARRHGVAVHGPCVNASLAHATCEnaGTEVRLGLGAVRYLGA 873
Cdd:PRK05673 763 KAHYPAEFMAALL----------TSdmdntdkvavYLDECRRMGIKVLPPDVNESLYDFTVV--DGDIRYGLGAIKGVGE 830
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489513042 874 ELAEKLVAERTANGPFTSLPDLTSRVQLSV---PQVEALATAGALGCFGMSRRE-----------ALWAAGAAATGRPDr 939
Cdd:PRK05673 831 GAVEAIVEAREEGGPFKDLFDFCARVDLKKvnkRVLESLIKAGAFDSLGPNRAAllasledavdaADQHKKAEASGQFD- 909
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489513042 940 LPGVGSSShipalPGMSELELAAADVW-----------ATG--VS--P-DSYptqflRADLDAMGVLPAERLGSVSDGDR 1003
Cdd:PRK05673 910 LFGGLGEE-----PEDVEVSVPDVEEWdkkeklagereTLGlyLSghPlDGY-----EDELRRLRDTRLADLEPTEGGSV 979
|
1050 1060 1070 1080 1090 1100 1110 1120
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489513042 1004 VLIAGAVTHRQRPATAQGVTF--INLEDETGMVNVLCTPGVWARHRKLAHTAPALLIRGQVQNASGAITVVAERMGRLTL 1081
Cdd:PRK05673 980 VTVAGLVVSVRRRVTKRGNKMaiVTLEDLSGRIEVMLFSEALEKYRDLLEEDRIVVVKGQVSFDDGGLRLTAREVMDLEE 1059
|
1130
....*....|
gi 489513042 1082 AVGARSRDFR 1091
Cdd:PRK05673 1060 ARAKYARPLR 1069
|
|
| polc |
TIGR00594 |
DNA-directed DNA polymerase III (polc); All proteins in this family for which functions are ... |
61-1036 |
0e+00 |
|
DNA-directed DNA polymerase III (polc); All proteins in this family for which functions are known are DNA polymerases. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]
Pssm-ID: 273161 [Multi-domain] Cd Length: 1022 Bit Score: 649.06 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489513042 61 LHAHSAYSFLDGASTPEELVEEAARLGLCALALTDHDGLYGAVRFAEAAAELDVRTVFGAELSLGATARTERPDPPGP-- 138
Cdd:TIGR00594 4 LHVHSDYSLLDGAAKIKPLVKKAKELGMPALALTDHGNMFGAVEFYKACKKAGIKPIIGCEAYVAPGSRFDKKRISKGke 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489513042 139 --HLLVLARGPEGYRRLSRQLAAAHLAGGEKgKPRYDFDALTEAAGGhWHILTGCRKGHVRQALSQGGPAAAQRALADLV 216
Cdd:TIGR00594 84 ayHLILLAKNNTGYRNLMKLSSLAYLEGFYY-KPRIDKELLEEHSEG-LIALSACLSGEVPYLLLLGEERLAEEAALKYQ 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489513042 217 DRFtPSRVSIELTHHGHPLDDERNAALAGLAPRFGVGIVATTGAHFADPSRGRLAMAMAAIRARRSLDSAAGWLAPLGGA 296
Cdd:TIGR00594 162 EIF-GDDYYLELQDHGIPEQRVVNEALLEISEELGIPLVATNDVHYINPEDAHAHEILLCIQTGKTLSDPKRLKFYSDEF 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489513042 297 HLRSGEEMARLFAWCPEAVTAAAELGERCA-FGLQLIAPRLPPFDVP-DGHTEDSWLRSLVMAGARERY--GPPKSAPRA 372
Cdd:TIGR00594 241 YLKSPEEMAELFADIPEALANTVEIAERCNlVDVKLGPPRLPSYQIPpDFTSQEDYLRHLADEGLRERLaaGPPGYKRRA 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489513042 373 --YSQIEHELKVIAQLRFPGYFLVVHDITRFCRDNDI-LCQGRGSAANSAVCYALGVTAVDPVANELLFERFLSPARDGP 449
Cdd:TIGR00594 321 qyKERLEYELDVINSMGFPGYFLIVWDFIKWAKDHGIpVGPGRGSAAGSLVAYALKITDIDPIKHGLLFERFLNPERISM 400
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489513042 450 PDIDIDIESDQREKVIQYVYHKYGRDYAAQVANVITYRGRSAVRDMARALGFSPGQQDAWSKQV--------SHWTGQAD 521
Cdd:TIGR00594 401 PDIDIDFCDERRDEVIEYVADKYGHDNVAQIITFGTMKAKAALRDVARVLDIPYAEADRIAKLIpprpgktlKEALEASP 480
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489513042 522 DVDGIPE------QVIDLATQIRNLPRHLGIHSGGMVICDRPIADVCPVeWARMANRSVL-QWDKDDCAAIGLVKFDLLG 594
Cdd:TIGR00594 481 QLRQLYEedpevkQLIDMARKLEGLNRNAGVHAAGVVISSEPLTDYVPL-YKDKEGGAIStQYDMDDLEAVGLLKMDFLG 559
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489513042 595 LGMLSALHYAKDLVAEHKGIEVDLARLDLSEPAVYEMLARADSVGVFQVESRAQMATLPRLKPRVFYDLVVEVALIRPGP 674
Cdd:TIGR00594 560 LKTLTLIQDATELIRKRRGIDLDIASIPLDDKKTFSLLQEGDTTGVFQLESRGMQDLLKRLKPDGFEDIIAVNALYRPGP 639
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489513042 675 IQGGSVHPYIRRRNGVDPVIYEHPSMAPALRKTLGVPLFQEQLMQLAVDCAGFSAAEADQLRRAMGSKRStERMRRLRGR 754
Cdd:TIGR00594 640 MESGMIPDFIDRKHGREPIEYPHPLLEPILKETYGVIVYQEQVMQIAQRLAGFSLGEADLLRRAMGKKKA-EEMAKEREK 718
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489513042 755 FYDGMRAlHGAPDEVIDRIYEKLEAFANFGFPESHALSFASLVFYSAWFKLHHPAAFCAALLRAQPMGFYSPQSLVADAR 834
Cdd:TIGR00594 719 FVEGAEK-NGYDPEIAENLFDLIEKFAGYGFNKSHAAAYGMISYQTAYLKANYPAEFMAALLTSEINDIEKVAVYIAEAK 797
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489513042 835 RHGVAVHGPCVNASLAHATCENAGteVRLGLGAVRYLGAELAEKLVAERTANGPFTSLPDLTSRVQLSV---PQVEALAT 911
Cdd:TIGR00594 798 KMGIEVLPPDINESGQDFAVEDKG--IRYGLGAIKGVGESVVKSIIEERNKNGPFKSLFDFINRVDFKKlnkKVLEALIK 875
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489513042 912 AGALGCFGMSRRE-----------ALWAAGAAATGRPDrLPGVGSSSHIPALP-GMSELELAAADVWA-----TGVSPDS 974
Cdd:TIGR00594 876 AGAFDSLGPNRKTllaslddaldaVSRKKKAEALGQNS-LFGALSEGTKPEYVfFPPDEEWPDKKLLAleketLGLYVSG 954
|
970 980 990 1000 1010 1020
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 489513042 975 YPTQFLRADLDAMGVLPAERLGSVSDGDRVLIAG---AVTHRQRPATAQGVTFINLEDETGMVNV 1036
Cdd:TIGR00594 955 HPLDAYEKALKNTATPAAIEDLEAPNDSQVRTLGglnSVKKKITTKNGKPMAFLQLEDETGSIEV 1019
|
|
| dnaE |
PRK06826 |
DNA polymerase III DnaE; Reviewed |
61-1063 |
0e+00 |
|
DNA polymerase III DnaE; Reviewed
Pssm-ID: 235868 [Multi-domain] Cd Length: 1151 Bit Score: 605.35 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489513042 61 LHAHSAYSFLDGASTPEELVEEAARLGLCALALTDHDGLYGAVRFAEAAAELDVRTVFGAELSLGATARTERPdpPGP-- 138
Cdd:PRK06826 8 LHVHTEYSLLDGSARIKDLIKRAKELGMDSIAITDHGVMYGVVDFYKAAKKQGIKPIIGCEVYVAPRSRFDKE--PDIdn 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489513042 139 ---HLLVLARGPEGYRRLSRQLAAAHLAGGEKgKPRYDFDALTEAAGGHwhI-LTGCRKGHVRQALSQGGPAAAQRALAD 214
Cdd:PRK06826 86 etyHLVLLAKNETGYKNLMKIVSKAFTEGFYY-KPRVDHELLKEHSEGL--IaLSACLAGEVPRYILKGNYEKAKEAALF 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489513042 215 LVDRFTPSRVSIELTHHGhpLDDER--NAALAGLAPRFGVGIVATTGAHF---------------------ADPSRGRLa 271
Cdd:PRK06826 163 YKDIFGKENFYLELQDHG--IPEQRkvNEELIKLSKELGIPLVATNDVHYirkedakahdvllciqtgktvDDENRMRF- 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489513042 272 mamaairarrsldsaagwlaPLGGAHLRSGEEMARLFAWCPEAVTAAAELGERCAFGLQLIAPRLPPFDVPDGHTEDSWL 351
Cdd:PRK06826 240 --------------------PSDEFYLKSPEEMYELFSYVPEALENTVKIAERCNVEFEFGKSKLPKFPLPEGYDPYEYL 299
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489513042 352 RSLVMAGARERYGPPKsaPRAYSQIEHELKVIAQLRFPGYFLVVHDITRFCRDNDILC-QGRGSAANSAVCYALGVTAVD 430
Cdd:PRK06826 300 RELCYEGLKKRYPNPS--EELIERLEYELSVIKQMGYVDYFLIVWDFIRFARENGIMVgPGRGSAAGSLVAYTLGITKID 377
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489513042 431 PVANELLFERFLSPARDGPPDIDIDIESDQREKVIQYVYHKYGRDYAAQVANVITYRGRSAVRDMARALGFSPGQQDAWS 510
Cdd:PRK06826 378 PIKYNLLFERFLNPERVSMPDIDIDFCYERRQEVIDYVVEKYGKDRVAQIITFGTMAARAAIRDVGRALNYPYAEVDRIA 457
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489513042 511 KQVSHWTGQADD--VDGIPE------------QVIDLATQIRNLPRHLGIHSGGMVICDRPIADVCPVewARMANRSVLQ 576
Cdd:PRK06826 458 KMIPTELGITIDkaLELNPElkeayendervrELIDTARALEGLPRHASTHAAGVVISSEPLVEYVPL--QKNDGSIVTQ 535
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489513042 577 WDKDDCAAIGLVKFDLLGLGMLSALHYAKDLVAEHKGIEVDLARLDLSEPAVYEMLARADSVGVFQVESRAQMATLPRLK 656
Cdd:PRK06826 536 FTMTTLEELGLLKMDFLGLRTLTVIRDAVDLIKKNRGIEIDLDKIDYDDKKVYKMIGEGKTVGVFQLESAGMRSFMKELK 615
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489513042 657 PRVFYDLVVEVALIRPGPIqgGSVHPYIRRRNGVDPVIYEHPSMAPALRKTLGVPLFQEQLMQLAVDCAGFSAAEADQLR 736
Cdd:PRK06826 616 PDSLEDIIAGISLYRPGPM--DSIPRYIKNKNNPEKIEYLHPKLEPILKVTYGCIVYQEQVMQIVRDLAGYSMGRSDLVR 693
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489513042 737 RAMgSKRSTERMRRLRGRFYDGMRALHGA-------PDEVIDRIYEKLEAFANFGFPESHALSFASLVFYSAWFKLHHPA 809
Cdd:PRK06826 694 RAM-SKKKHDVMEEERKNFIYGIVDEGGPgcirngiDEETANKIFDSMMDFASYAFNKSHAAAYAVVAYQTAYLKRYYPV 772
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489513042 810 AFCAALLRA-----QPMGFYspqslVADARRHGVAVHGPCVNASLAHATCEnaGTEVRLGLGAVRYLGAELAEKLVAERT 884
Cdd:PRK06826 773 EFMAALLNSvmgnsDKVAFY-----IEECRRLGIEVLPPDINESYSKFTVE--GDKIRFGLAAVKNVGENAIDSIVEERE 845
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489513042 885 ANGPFTSLPDLTSRVQLSVPQ---VEALATAGALGCFGMSRRE-----------ALWAAGAAATGRP---DRLPGVGSSS 947
Cdd:PRK06826 846 KKGKFKSLVDFCERVDTSQINkraVESLIKAGAFDSLGVYRSQllavyekildsISKQRKKNIEGQIslfDLIGEEEESS 925
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489513042 948 HIPALPGMSEL---ELAAADVWATGVSPDSYPTQFLRADLDAMGVLPAERLGS---------VSDGDRVLIAGAVTHRQR 1015
Cdd:PRK06826 926 LEIKYPDIKEFdkkELLAMEKEMLGLYISGHPLEEYEETLKKQTSATISDIISdeeedgeskLKDGDKVIIGGIITEVKR 1005
|
1050 1060 1070 1080 1090
....*....|....*....|....*....|....*....|....*....|
gi 489513042 1016 PATAQGVT--FINLEDETGMVNVLCTPGVWARHRKLAHTAPALLIRGQVQ 1063
Cdd:PRK06826 1006 KTTRNNEMmaFLTLEDLYGTVEVIVFPKVYEKYRSLLNEDNIVLIKGRVS 1055
|
|
| dnaE |
PRK07374 |
DNA polymerase III subunit alpha; Validated |
57-918 |
2.22e-158 |
|
DNA polymerase III subunit alpha; Validated
Pssm-ID: 168927 [Multi-domain] Cd Length: 1170 Bit Score: 500.79 E-value: 2.22e-158
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489513042 57 AYAELHAHSAYSFLDGASTPEELVEEAARLGLCALALTDHDGLYGAVRFAEAAAELDVRTVFGAELSLgATARTERPDP- 135
Cdd:PRK07374 2 AFVPLHNHSDYSLLDGASQLPKMVERAKELGMPAIALTDHGVMYGAIELLKLCKGKGIKPIIGNEMYV-INGSIDDPQPk 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489513042 136 --PGPHLLVLARGPEGYRRLSRQLAAAHLAG----GEKGKPRYDFDALTEAAGGhWHILTGCRKGHVRQALSQGGPAAAQ 209
Cdd:PRK07374 81 keKRYHLVVLAKNATGYKNLVKLTTISHLNGmrgrGIFSRPCIDKELLKQYSEG-LIVSTACLGGEIPQAILRGRPDVAR 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489513042 210 RALADLVDRFTPSrVSIELTHHGHPLDDERNAALAGLAPRFGVGIVATTGAHFAdpSRGRLAMAMAAI-RARRSLDSAAG 288
Cdd:PRK07374 160 DVAAWYKEVFGDD-FYLEIQDHGSIEDRIVNVELVRIAKELGIKLIATNDAHYL--SKNDVEAHDALLcVLTGKLISDEK 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489513042 289 WLAPLGGAHLRSGEEMARLFA------WCPEAVTAAAELGERCAFGLQLIAPRLPPFDVPDGHTEDSWLRSLVMAGARER 362
Cdd:PRK07374 237 RLRYTGTEYIKSEEEMLRLFRdhldpeVIQEAIANTVEVAEKVEEYDILGTYRMPRFPIPEGHTAVSYLTEVTEQGLLKR 316
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489513042 363 YG--PPKSAPRAYSQ-IEHELKVIAQLRFPGYFLVVHDITRFCRDNDI-LCQGRGSAANSAVCYALGVTAVDPVANELLF 438
Cdd:PRK07374 317 LKlnSLDEIDENYKErLSYELKIIEQMGFPTYFLVVWDYIRFAREQGIpVGPGRGSAAGSLVAYALGITNIDPVKNGLLF 396
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489513042 439 ERFLSPARDGPPDIDIDIESDQREKVIQYVYHKYGRDYAAQVanvITYR---GRSAVRDMARALGFSPGQQDAWSKQVSH 515
Cdd:PRK07374 397 ERFLNPERKSMPDIDTDFCIERRGEVIDYVTRRYGEDKVAQI---ITFNrmtSKAVLKDVARVLDIPYGEADRLAKLIPV 473
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489513042 516 WTG-------------------QADDVDGIPEQVIDLATQIRNLPRHLGIHSGGMVICDRPIADVCPVEwaRMANRSVL- 575
Cdd:PRK07374 474 VRGkpaklkamigkespspefrEKYEKDPRVKKWVDMAMRIEGTNKTFGVHAAGVVIASDPLDELVPLQ--RNNDGQVIt 551
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489513042 576 QWDKDDCAAIGLVKFDLLGLGMLSALHYAKDLVAEHKGIEVDLARLDLSEPAVYEMLARADSVGVFQVESRAQMATLPRL 655
Cdd:PRK07374 552 QYFMEDIESLGLLKMDFLGLKNLTMIEKTLELVEQSTGERIDPDNLPLDDEKTFELLARGDLEGIFQLESSGMRQVVRDL 631
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489513042 656 KPRVFYDLVVEVALIRPGPIQGGSVHPYIRRRNGVDPVIYEHPSMAPALRKTLGVPLFQEQLMQLAVDCAGFSAAEADQL 735
Cdd:PRK07374 632 KPSSLEDISSILALYRPGPLDAGLIPKFINRKHGREAIDFAHPLLEPILTETYGIMVYQEQIMKIAQDLAGYSLGQADLL 711
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489513042 736 RRAMGSKRSTErMRRLRGRFYDGMrALHGAPDEVIDRIYEKLEAFANFGFPESHALSFASLVFYSAWFKLHHPAAFCAAL 815
Cdd:PRK07374 712 RRAMGKKKVSE-MQKHRGIFVEGA-SKRGVDEKVADELFDQMVLFAEYCFNKSHSTAYGAVTYQTAYLKAHYPVAYMAAL 789
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489513042 816 LRAQPMGFYSPQSLVADARRHGVAVHGPCVNASLAHATceNAGTEVRLGLGAVRYLGAELAEKLVAERTANGPFTSLPDL 895
Cdd:PRK07374 790 LTVNAGSSDKVQRYISNCNSMGIEVMPPDINRSGIDFT--PKGNRILFGLSAVKNLGDGAIRNIIAARDSDGPFKSLADL 867
|
890 900
....*....|....*....|....*.
gi 489513042 896 TSRVQLSVPQ---VEALATAGALGCF 918
Cdd:PRK07374 868 CDRLPSNVLNrrsLESLIHCGALDAF 893
|
|
| dnaE |
PRK06920 |
DNA polymerase III subunit alpha; |
58-1063 |
1.54e-149 |
|
DNA polymerase III subunit alpha;
Pssm-ID: 180749 [Multi-domain] Cd Length: 1107 Bit Score: 475.44 E-value: 1.54e-149
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489513042 58 YAELHAHSAYSFLDGASTPEELVEEAARLGLCALALTDHDGLYGAVRFAEAAAELDVRTVFGAELSLgATARTERPDPpg 137
Cdd:PRK06920 3 FVHLQCQTVFSLLKSACKIDELVVRAKELGYSSLAITDENVMYGVIPFYKACKKHGIHPIIGLTASI-FSEEEEKSYP-- 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489513042 138 phLLVLARGPEGYRRLSRQLAAAHLAGGEKGKPRYdfdaLTEAAGGHWHILTGcRKGHVRQALSQGGPAAAQRALADLVD 217
Cdd:PRK06920 80 --LVLLAENEIGYQNLLKISSSIMTKSKEGIPKKW----LAHYAKGLIAISPG-KDGEIEQLLLEDKESQAEEVARAYQN 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489513042 218 RFTPSRVSIELthhgHPLDDER--NAALAGLAPRFGVGIVATTGAHFADPSRGRLAMAMAAIRARRSLDSAAGWLAPLGG 295
Cdd:PRK06920 153 MFGNFYMSLQH----HAIQDELllQEKLPEFSNRVNIPVVATNDVRYINQSDALVHECLLSVESGTKMTDPDRPRLKTDQ 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489513042 296 AHLRSGEEMARLFAWCPEAVTAAAELGERCAFGLQLIAPRLPPFDVPDGHTEDSWLRSLVMAGARERYGPPKSapRAYSQ 375
Cdd:PRK06920 229 YYLKSSDEMEALFSHVPEAIYNTVEIAERCRVEIPFHVNQLPKFPVPSNETADMYLRRVCEEGLQKRYGTPKE--VHINR 306
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489513042 376 IEHELKVIAQLRFPGYFLVVHDITRFCRDNDILC-QGRGSAANSAVCYALGVTAVDPVANELLFERFLSPARDGPPDIDI 454
Cdd:PRK06920 307 LNHELNVISRMGFSDYFLIVWDFMKYAHENHILTgPGRGSAAGSLVSYVLEITDIDPIEYDLLFERFLNPERVTLPDIDI 386
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489513042 455 DIESDQREKVIQYVYHKYGRDYAAQVANVITYRGRSAVRDMARALGFSPGQQDAWSKQVSHWTG--------QADDVD-- 524
Cdd:PRK06920 387 DFPDTRRDEMIRYVKDKYGQLRVAQIVTFGTLAAKAAIRDIARVMGLPPRDIDIFSKLIPSKLGitlkdayeESQSLRef 466
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489513042 525 ----GIPEQVIDLATQIRNLPRHLGIHSGGMVICDRPIADVCPVEWARmANRSVLQWDKDDCAAIGLVKFDLLGLGMLSA 600
Cdd:PRK06920 467 iqgnLLHERVFEIAKRVEGLPRHTSIHAAGVIMSQEPLTGSVAIQEGH-NDVYVTQYPADALEELGLLKMDFLGLRNLTL 545
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489513042 601 LHYAKDLVAEHKGIEVDLARLDLSEPAVYEMLARADSVGVFQVESRAQMATLPRLKPRVFYDLVVEVALIRPGPIQggSV 680
Cdd:PRK06920 546 LENIIKFIEQKTGKEIDIRNLPLQDEKTFQLLGRGDTTGVFQLESSGMRNVLRGLKPNEFEDIVAVNSLYRPGPME--QI 623
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489513042 681 HPYIRRRNGVDPVIYEHPSMAPALRKTLGVPLFQEQLMQLAVDCAGFSAAEADQLRRAMgSKRSTERMRRLRGRFYDGMR 760
Cdd:PRK06920 624 PTFIESKHGKRKIEYLHPDLKPILERTYGVIVYQEQIMQIASKLAGFSLGEADLLRRAV-SKKNRDILDQERKHFVQGCL 702
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489513042 761 AlHGAPDEVIDRIYEKLEAFANFGFPESHALSFASLVFYSAWFKLHHPAAFCAALLRAQPMGFYSPQSLVADARRHGVAV 840
Cdd:PRK06920 703 Q-NGYDETSAEKIYDLIVRFANYGFNRSHAVAYSMIGYQLAYLKANYTLEFMTALLSSAIGNEDKIVQYIRETKRKGFHV 781
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489513042 841 HGPCVNASLAHATCENAgtEVRLGLGAVRYLGAELAEKLVAERTaNGPFTSLPDLTSRVQL-SVPQ--VEALATAGALGC 917
Cdd:PRK06920 782 LPPSLQRSGYNFQIEGN--AIRYSLLSIRNIGMATVTALYEERE-KKMFEDLFEFCLRMPSkFVTErnLEAFVWSGCFDD 858
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489513042 918 FGMSRR------EALWAAGAAATGRPDRLPgvgsSSHIPALPGMSELELAAADVWATGVSPDSYPTQFLRADLDAMGVLP 991
Cdd:PRK06920 859 FGVSRTnlwkslKGALEYANLARDLGDAVP----KSKYVQGEELSFIEQLNKEKEVLGFYLSSYPTAQYVKLAKELEIPS 934
|
970 980 990 1000 1010 1020 1030
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 489513042 992 AERLgsVSDGDRVLIAGAVTHRQ---RPATAQGVTFINLEDETGMVNVLCTPGVWARHRKLAHTAPALLIRGQVQ 1063
Cdd:PRK06920 935 LAQA--MRHKKKVQRAIVYITSVkviRTKKGQKMAFITFCDQNDEMEAVVFPETYIHFSDKLQEGAIVLVDGTIE 1007
|
|
| PRK09532 |
PRK09532 |
DNA polymerase III subunit alpha; Reviewed |
61-783 |
1.25e-123 |
|
DNA polymerase III subunit alpha; Reviewed
Pssm-ID: 181933 [Multi-domain] Cd Length: 874 Bit Score: 400.27 E-value: 1.25e-123
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489513042 61 LHAHSAYSFLDGASTPEELVEEAARLGLCALALTDHDGLYGAVRFAEAAAELDVRTVFGAELSLGATARTERPDPPGPHL 140
Cdd:PRK09532 6 LHIHSDYSLLDGASQLPALVDRAIELGMPAIALTDHGVMYGAIELLKVCRNKGIKPIIGNEMYVINGDIEKQKRRRKYHQ 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489513042 141 LVLARGPEGYRRLSRQLAAAHLAGGE-KG---KPRYDFDALTEAAGGHwhILT-GCRKGHVRQALSQGGPAAAQRALADL 215
Cdd:PRK09532 86 VVLAKNTQGYKNLVKLTTISHLQGVQgKGifaRPCINKELLEQYHEGL--IVTsACLGGEIPQAILSGRPDAARKVAKWY 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489513042 216 VDRFTPSrVSIELTHHGHPLDDERNAALAGLAPRFGVGIVATTGAHFAD----PSRGRLAMAMAAirarrSLDSAAGWLA 291
Cdd:PRK09532 164 KKLFGDD-FYLEIQDHGSQEDRIVNVEIVKIARELGIKIIATNDSHFIScydvEAHDALLCIQTG-----KLITEDKRLR 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489513042 292 PLGGAHLRSGEEMARLF------AWCPEAVTAAAELGERCAFGLQLIAPRLPPFDVPDGHTEDSWLRSLVMAGARERYGP 365
Cdd:PRK09532 238 YSGTEYLKSAEEMRLLFrdhlpdDVIAEAIANTLEVADKIEPYNILGEPRIPNYPVPSGHTPDTYVEEVAWQGLLERLNC 317
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489513042 366 PKSA--PRAYSQ-IEHELKVIAQLRFPGYFLVVHDITRFCRDNDI-LCQGRGSAANSAVCYALGVTAVDPVANELLFERF 441
Cdd:PRK09532 318 KSRSevEPVYKErLEYELKMLQQMGFSTYFLVVWDYIKYARDNNIpVGPGRGSAAGSLVAYCLKITNIDPVHHGLLFERF 397
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489513042 442 LSPARDGPPDIDIDIESDQREKVIQYVYHKYGRDyaaQVANVITYR---GRSAVRDMARALGFSPGQQDAWSK------- 511
Cdd:PRK09532 398 LNPERKSMPDIDTDFCIERRDEMIKYVTEKYGED---RVAQIITFNrmtSKAVLKDVARVLDIPYGEADKMAKlipvsrg 474
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489513042 512 -------QVSHWTGQAD-----DVDGIPEQVIDLATQIRNLPRHLGIHSGGMVICDRPIADVCPVEwaRMANRSVL-QWD 578
Cdd:PRK09532 475 kptklkvMISDETPEPEfkekyDNDPRVRRWLDMAIRIEGTNKTFGVHAAGVVISSEPLDEIVPLQ--KNNDGAVItQYF 552
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489513042 579 KDDCAAIGLVKFDLLGLGMLSALHYAKDLVAEHKGIEVDLARLDLSE-------------------PAVYEMLARADSVG 639
Cdd:PRK09532 553 MEDLESLGLLKMDFLGLRNLTTIQKTADLIKENRGVEIDLDQLPLDErkalkilakgeakklpkdvQKTHKLLERGDLEG 632
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489513042 640 VFQVESRAQMATLPRLKPRVFYDLVVEVALIRPGPIQGGSVHPYIRRRNGVDPVIYEHPSMAPALRKTLGVPLFQEQLMQ 719
Cdd:PRK09532 633 IFQLESSGMKQIVRDLKPSNIEDISSILALYRPGPLDAGLIPKFINRKHGREPIDYEHQLLEPILNETYGVLVYQEQIMK 712
|
730 740 750 760 770 780
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 489513042 720 LAVDCAGFSAAEADQLRRAMGSKRSTErMRRLRGRFYDGMrALHGAPDEVIDRIYEKLEAFANF 783
Cdd:PRK09532 713 MAQDLAGYSLGEADLLRRAMGKKKISE-MQKHREKFIDGA-AKNGVSKKVAENLFDQMVKFAEY 774
|
|
| DNA_pol3_alpha |
pfam07733 |
Bacterial DNA polymerase III alpha NTPase domain; |
349-594 |
9.94e-118 |
|
Bacterial DNA polymerase III alpha NTPase domain;
Pssm-ID: 400196 [Multi-domain] Cd Length: 259 Bit Score: 363.36 E-value: 9.94e-118
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489513042 349 SWLRSLVMAGARERYGPPKSaPRAYSQIEHELKVIAQLRFPGYFLVVHDITRFCRDNDILC-QGRGSAANSAVCYALGVT 427
Cdd:pfam07733 1 EYLRKLVEEGLKERYGEGLP-EEYQERLEYELNVIIKMGFAGYFLIVWDLVKWAKDNGILVgPGRGSAAGSLVAYLLGIT 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489513042 428 AVDPVANELLFERFLSPARDGPPDIDIDIESDQREKVIQYVYHKYGRDYAAQVANVITYRGRSAVRDMARALGFSPGQQD 507
Cdd:pfam07733 80 EVDPLKHDLLFERFLNPERVSMPDIDIDFEDERREEVIDYVKEKYGRDRVAQIATFGTYAAKSAIRDVGRALGLPYDEID 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489513042 508 AWSKQVSHWTG-------------QADDVDGIPEQVIDLATQIRNLPRHLGIHSGGMVICDRPIADVCPVEWARMANRSV 574
Cdd:pfam07733 160 RLAKLIPFELGilekaleeepelkELIESDPEVKRLIELAKKLEGLPRHTGQHAGGVVISPDPLTDFVPLYKADDDDRPV 239
|
250 260
....*....|....*....|
gi 489513042 575 LQWDKDDCAAIGLVKFDLLG 594
Cdd:pfam07733 240 TQFDKDDLEDLGLLKMDFLG 259
|
|
| dnaE |
PRK07279 |
DNA polymerase III DnaE; Reviewed |
58-923 |
4.84e-111 |
|
DNA polymerase III DnaE; Reviewed
Pssm-ID: 180917 [Multi-domain] Cd Length: 1034 Bit Score: 370.13 E-value: 4.84e-111
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489513042 58 YAELHAHSAYSFLDGASTPEELVEEAARLGLCALALTDHDGLYGAVRFAEAAAELDVRTVFGAELSLgatARTERPDPpg 137
Cdd:PRK07279 2 FAQLDTKTVYSFMDSLIDLEKYVERAKELGYQTIGIMDKDNLYGAYHFIEGAQKNGLQPILGLELNI---FVEEQEVT-- 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489513042 138 phLLVLARGPEGYRRLSRqLAAAHLAGgekgkpRYDFDALTEAAGGHWHILtgcrkghvrqalsqggPAAAQRALADL-V 216
Cdd:PRK07279 77 --LRLIAKNTQGYKNLLK-ISTAKMSG------KKQFSDLSQYLEGIAVIV----------------PYFDWSETLELpF 131
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489513042 217 DRFTPSRVSIELTHHGHPL---------DDERNAALAGL-APRFGVgivattgahfadpsrgrlamamaairarrSLDSA 286
Cdd:PRK07279 132 DYYIGVDQETPGSDFKRPIlplrtvryfESADRETLQMLhAIRDNL-----------------------------SLREV 182
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489513042 287 AgwLAPlGGAHLRSGEEMARLF-AWCPEAVTAAAELGERCA--FGLQLIAPRLPPfDVPDGHTedswLRSLVMAGARERy 363
Cdd:PRK07279 183 P--LVS-SDQELISCQSLETLFqERFPQALDNLEKLVSGISydFDTDLKLPRFNR-DRPAVEE----LRELAELGLKEK- 253
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489513042 364 GPPKSApraY-SQIEHELKVIAQLRFPGYFLVVHDITRFCRDNDILC-QGRGSAANSAVCYALGVTAVDPVANELLFERF 441
Cdd:PRK07279 254 GLWSSP---YqERLDKELSVIHDMGFDDYFLIVWDLLRFGRSQGYYMgMGRGSAAGSLVAYALDITGIDPVKHNLLFERF 330
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489513042 442 LSPARDGPPDIDIDIESDQREKVIQYVYHKYGRDYAAQVANVITYRGRSAVRDMARALGFSPGQQDAWSKQVSHWTGQAD 521
Cdd:PRK07279 331 LNKERYSMPDIDIDLPDIYRSEFLRYVRNRYGSDHSAQIVTFSTFGAKQAIRDVFKRFGVPEYELSNLTKKISFRDSLAS 410
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489513042 522 DVDGIP--EQVI----------DLATQIRNLPRHLGIHSGGMVICDRPIADVCPVEWAR-MAnrsVLQWDKDDCAAIGLV 588
Cdd:PRK07279 411 VYEKNIsfRQIInskleyqkafEIAKRIEGNPRQTSIHAAGVVMSDDDLTNHIPLKYGDdMM---ITQYDAHAVEANGLL 487
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489513042 589 KFDLLGLGMLSALHYAKDLVAEHKGIEVDLARLDLSEPAVYEMLARADSVGVFQVESRAQMATLPRLKPRVFYDLVVEVA 668
Cdd:PRK07279 488 KMDFLGLRNLTFVQKMQEKVAKDYGIHIDIEAIDLEDKETLALFAAGDTKGIFQFEQPGAINLLKRIKPVCFEDIVATTS 567
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489513042 669 LIRPGPIQggSVHPYIRRRNGVDPVIYEHPSMAPALRKTLGVPLFQEQLMQLAVDCAGFSAAEADQLRRAMGSKRSTErM 748
Cdd:PRK07279 568 LNRPGASD--YTDNFVKRRHGQEKVDLIDPVIAPILEPTYGIMLYQEQVMQIAQVFAGFSLGKADLLRRAMSKKNASE-M 644
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489513042 749 RRLRGRFYDGMRALhGAPDEVIDRIYEKLEAFANFGFPESHALSFASLVFYSAWFKLHHPAAFCAALLRaqpmgfYSPQS 828
Cdd:PRK07279 645 QKMEEDFLQGALEL-GHSEEKARELFDRMEKFAGYGFNRSHAFAYSALAFQLAYFKAHYPAVFYDIMLN------YSSSD 717
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489513042 829 LVADARRHGVAVHGPCVNASLAHATCENAgtEVRLGLGAVRYLGAELAEKLVAERtangPFTSLPDLTSRVQ---LSVPQ 905
Cdd:PRK07279 718 YITDALEFGFEVAKLSINTIPYHDKIENK--KIYLGLKNIKGLPRDLAYWIIENR----PFSSIEDFLTRLPenyQKKEF 791
|
890
....*....|....*...
gi 489513042 906 VEALATAGALGCFGMSRR 923
Cdd:PRK07279 792 LEPLIKIGLFDSFEKNRQ 809
|
|
| dnaE |
PRK07135 |
DNA polymerase III DnaE; Validated |
334-919 |
3.63e-104 |
|
DNA polymerase III DnaE; Validated
Pssm-ID: 235944 [Multi-domain] Cd Length: 973 Bit Score: 350.14 E-value: 3.63e-104
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489513042 334 PRLPPFDVPDGHTEDSWLRSLVMAGARERYGPPKSAPRAYSQIEHELKVIAQLRFPGYFLVVHDITRFCRDNDILC-QGR 412
Cdd:PRK07135 214 FNLPDFDNNLGLESDLFLKKILKESVINKKAELKYYPNVKERINYEYSVIKKLKFSNYFLIIWDFIKWARKNKISIgPGR 293
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489513042 413 GSAANSAVCYALGVTAVDPVANELLFERFLSPARDGPPDIDIDIESDQREKVIQYVYHKYGRDYAAQVANVITYRGRSAV 492
Cdd:PRK07135 294 GSASGSLVSYLLNITSVNPLKYDLLFERFLNPDRITMPDIDIDIQDDRRDEVIDYIFEKYGYEHCATISTFQTLGAKSAI 373
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489513042 493 RDMARALGFSPGQQDAWSKQV--------------SHWTGQADDVDGIPEQVIDLATQIRNLPRHLGIHSGGMVICDRPI 558
Cdd:PRK07135 374 RDVGRMLGIPESDVNAISKLIpnnqsleeaydknkSFFRELISKGDPIYKKLYKIAKKLEGLPRQSGTHAAGIIISNKPI 453
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489513042 559 ADVCPVeWARMANRSVLQWDKDDCAAIGLVKFDLLGLGMLSALHYAKDLVAEHKGI--EVDLARLDLSEPAVYEMLARAD 636
Cdd:PRK07135 454 TNYVPT-FESKDNYNQVQYSMEFLEDFGLLKIDLLGLKNLTIIKNIEEKINKELLFdhLINFNDLPIIDKKTNNLLSNGK 532
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489513042 637 SVGVFQVESRAQMATLPRLKPRVFYDLVVEVALIRPGPIQGGSVhpYIRRRNgvDPVIYE--HPSMAPALRKTLGVPLFQ 714
Cdd:PRK07135 533 TEGIFQLESPGMKSTIKKVGIDSFEDIVAIISLYRPGPIQYIPI--YAKNKK--NPKNIEkiHPEYDEIVAPTYGIIIYQ 608
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489513042 715 EQLMQLAVDCAGFSAAEADQLRRAMgSKRSTERMRRLRGRFYDGmRALHGAPDEVIDRIYEKLEAFANFGFPESHALSFA 794
Cdd:PRK07135 609 EQIMQIAQKVAGFSFAQADLLRRAI-SKKDETKLDKIKDKFIEG-GIKNGYSKKVLEKIYSLIEKFADYGFNKSHAVAYA 686
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489513042 795 SLVFYSAWFKLHHPAAFCAALLRAQPMGFYSPQSLVADARRHGVAVHGPCVNASLAHATCENagTEVRLGLGAVRYLGAE 874
Cdd:PRK07135 687 TLAYKMAYYKANYPLVFYSALISNSNGSQENIKKYVKEAKNNGIKVYSPDINFSTENAVFDN--GKIFLPLIMIKGLGSV 764
|
570 580 590 600
....*....|....*....|....*....|....*....|....*...
gi 489513042 875 LAEKLVAERTANGPFTSLPDLTSR---VQLSVPQVEALATAGALGCFG 919
Cdd:PRK07135 765 AIKKIIDERNKNGKYKNFFDFILRlkfIGISKSIIEKLIKANTLRSFG 812
|
|
| dnaE |
PRK05898 |
DNA polymerase III subunit alpha; |
297-922 |
1.65e-92 |
|
DNA polymerase III subunit alpha;
Pssm-ID: 135648 [Multi-domain] Cd Length: 971 Bit Score: 317.94 E-value: 1.65e-92
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489513042 297 HLRSGEEMARLFAwcPEAVTAAAELGERCAFGLQLIAPRLPPFDVPDGHTEDSWLRSLVMAGARERYGPPKSAPRAYSQ- 375
Cdd:PRK05898 179 HFLNDNEAQSLFS--PIQLDNLNKVLNELKVEIHDLPINIIKYDKQNSIISSEILKQLCISGLNKRLNANDGQVKKIYVk 256
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489513042 376 -IEHELKVIAQLRFPGYFLVVHDITRFCRDNDILC-QGRGSAANSAVCYALGVTAVDPVANELLFERFLSPARDGPPDID 453
Cdd:PRK05898 257 rLKYELDIINEKQFDDYFLIVYDFINFAKSNGIIIgPGRGSAAGSLIAYLLHITDIDPIKYNLIFERFLNPTRKSMPDID 336
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489513042 454 IDIESDQREKVIQYVYHKYGRDYaaqVANVITY---RGRSAVRDMARALGFSPGQQDAWSKQVShwTGQADDVDG----- 525
Cdd:PRK05898 337 TDIMDERRDEVVEYLFEKYGNDH---VAHIITFqriKAKMAIRDVGRILGIDLKVIDKICKNIK--PDYEEDLDLaikkn 411
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489513042 526 --------IPEQVIDLATQIRNLPRHLGIHSGGMVICDRPIADVCPVEWArMANRSVLQWDKDDCAAIGLVKFDLLGLGM 597
Cdd:PRK05898 412 tilkemyvLHKELFDLAKKIINAPRQIGTHAAGVVLSNSLLTNIIPIQLG-INDRPLSQYSMEYLERFGLIKMDLLGLKN 490
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489513042 598 LSALHYAKDLVAEHKGIEVDLARLDLSEPAVYEMLARADSVGVFQVESRAQMATLPRLKPRVFYDLVVEVALIRPGPIQg 677
Cdd:PRK05898 491 LTIIDNVLKLIKENQNKKIDLFNINLNDKNVFEDLAKGRTNGIFQLESPGMKKVLKKVKPQNIEDISIVSALFRPGPQQ- 569
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489513042 678 gSVHPYIRRRNGVDPVIYEHPSMAPALRKTLGVPLFQEQLMQLAVDCAGFSAAEADQLRRAMgSKRSTERMRRLRGRFYD 757
Cdd:PRK05898 570 -NIKTFVERRFKREEFSYWNEATKKILEPTHGIIVYQEQVINLVKTIANFDIATADNFRRAI-SKKDEKILIQLKKDFIE 647
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489513042 758 GMRALHGAPDEViDRIYEKLEAFANFGFPESHALSFASLVFYSAWFKLHHPAAFCAALLRAQPMGFYSPQSLVADARRHG 837
Cdd:PRK05898 648 GALKNNYKQPLV-NQIFEYIFSFADYGFNHSHSLAYSYISYWMAYLKHYYPLEFLSILLSHTSASKDKLLSYLNEAKEFN 726
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489513042 838 VAVHGPCVNASLAHATCENAGTEVRLGLGAVRYLGAELAEKLVAERTAN--GPFTSLPDLTSRVQLSVPQVEALATAGAL 915
Cdd:PRK05898 727 ISIKKPDINYSSNSFVLDTQKQIIRFGFNTIKGFGDELLKKIKSALQNKtfSDFISYIDALKKNNVSLSNIEILINVGTF 806
|
....*..
gi 489513042 916 GCFGMSR 922
Cdd:PRK05898 807 DSFKLSR 813
|
|
| DNA_pol3_finger |
pfam17657 |
Bacterial DNA polymerase III alpha subunit finger domain; |
597-761 |
7.37e-73 |
|
Bacterial DNA polymerase III alpha subunit finger domain;
Pssm-ID: 407553 [Multi-domain] Cd Length: 166 Bit Score: 238.59 E-value: 7.37e-73
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489513042 597 MLSALHYAKDLVAEHKGIEVDLARLDLSEPAVYEMLARADSVGVFQVESRAQMATLPRLKPRVFYDLVVEVALIRPGPIQ 676
Cdd:pfam17657 1 TLTIIRDALDLIKENRGIGIDLATIPLDDPKTYKLLSSGDTLGVFQFESRGMRQMLKRLKPDTFEDLVALSALYRPGPMQ 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489513042 677 GGSVHPYIRRRNGVDPVIYEHPSMAPALRKTLGVPLFQEQLMQLAVDCAGFSAAEADQLRRAMGsKRSTERMRRLRGRFY 756
Cdd:pfam17657 81 GGNVDDYIKRKHGKEKIEYPHPDLEPILKETYGVIVYQEQVMQIAQILAGFSLGEADLLRRAMG-KKKPEEMEKLREKFI 159
|
....*
gi 489513042 757 DGMRA 761
Cdd:pfam17657 160 EGAKE 164
|
|
| PHP_PolIIIA_DnaE2 |
cd07434 |
Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at ... |
58-329 |
3.16e-51 |
|
Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at DnaE2 gene; PolIIIA DnaE2 plays a role in SOS mutagenesis/translesion synthesis and has dominant effects in determining GC variability in the bacterial genome. PolIIIAs that contain an N-terminal PHP domain have been classified into four basic groups based on genome composition, phylogenetic, and domain structural analysis: polC, dnaE1, dnaE2, and dnaE3. The PHP (also called histidinol phosphatase-2/HIS2) domain is associated with several types of DNA polymerases, such as PolIIIA and family X DNA polymerases, stand alone histidinol phosphate phosphatases (HisPPases), and a number of uncharacterized protein families. DNA polymerase III holoenzyme is one of the five eubacterial DNA polymerases that are responsible for the replication of the DNA duplex. PolIIIA core enzyme catalyzes the reaction for polymerizing both DNA strands. PolC PHP is located in a different location compared to dnaE1, 2, and 3. dnaE1 is the longest compared to dnaE2 and dnaE3. A unique motif was also identified in dnaE1 and dnaE3 genes. The PHP domain has four conserved sequence motifs and contains an invariant histidine that is involved in metal ion coordination. PHP domains found in DnaEs of thermophilic origin exhibit 3'-5' exonuclease activity.
Pssm-ID: 213989 [Multi-domain] Cd Length: 260 Bit Score: 181.12 E-value: 3.16e-51
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489513042 58 YAELHAHSAYSFLDGASTPEELVEEAARLGLCALALTDHDGLYGAVRFAEAAAELDVRTVFGAELSLgatarterpdPPG 137
Cdd:cd07434 1 YAELHCLSNFSFLRGASHPEELVARAAELGYRALAITDECSLAGVVRAHAAAKELGLKLIVGSELVL----------ADG 70
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489513042 138 PHLLVLARGPEGYRRLSRQLAAAHLAGgEKGKPRYDFDALTEAAGGHWHILTGcrkghvrqALSQGGPAAAQRALADLVD 217
Cdd:cd07434 71 TRLVLLARDRAGYGRLCRLITLGRRRA-EKGEYRLTLADLLAHAEGLLLILLP--------PDRLPAAAALLAQLRWLAR 141
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489513042 218 RFtPSRVSIELTHHGHPLDDERNAALAGLAPRFGVGIVATTGAHFADPSRGRLAMAMAAIRARRSLDSAAGWLAPLGGAH 297
Cdd:cd07434 142 AF-PGRLWLALELHLGGDDARRLARLAALAAALGLPLVATGDVLMHSPSRRPLQDVLTAIRLGTTVAEAGRRLAANAERH 220
|
250 260 270
....*....|....*....|....*....|..
gi 489513042 298 LRSGEEMARLFAWCPEAVTAAAELGERCAFGL 329
Cdd:cd07434 221 LRSPAELARLFLYPPEALAETLEIAARCTFSL 252
|
|
| PHP_PolIIIA |
cd07431 |
Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III; ... |
59-192 |
3.75e-50 |
|
Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III; PolIIIAs that contain an N-terminal PHP domain have been classified into four basic groups based on genome composition, phylogenetic, and domain structural analysis: polC, dnaE1, dnaE2, and dnaE3. The PHP (also called histidinol phosphatase-2/HIS2) domain is associated with several types of DNA polymerases, such as PolIIIA and family X DNA polymerases, stand alone histidinol phosphate phosphatases (HisPPases), and a number of uncharacterized protein families. DNA polymerase III holoenzyme is one of the five eubacterial DNA polymerases that is responsible for the replication of the DNA duplex. The alpha subunit of DNA polymerase III core enzyme catalyzes the reaction for polymerizing both DNA strands. The PolIIIA PHP domain has four conserved sequence motifs and contains an invariant histidine that is involved in metal ion coordination, and like other PHP structures, exhibits a distorted (beta/alpha) 7 barrel and coordinates up to 3 metals. Initially, it was proposed that PHP region might be involved in pyrophosphate hydrolysis, but such activity has not been found. It has been shown that the PHP domain of PolIIIA has a trinuclear metal complex and is capable of proofreading activity.
Pssm-ID: 213986 [Multi-domain] Cd Length: 179 Bit Score: 175.08 E-value: 3.75e-50
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489513042 59 AELHAHSAYSFLDGASTPEELVEEAARLGLCALALTDHDGLYGAVRFAEAAAELDVRTVFGAELSLGatarterPDPPGP 138
Cdd:cd07431 1 AHLHVHSSYSLLDSAIRPEDLVARAKELGYSALALTDRNVLYGAVRFYKACKKAGIKPIIGLELTVE-------GDGEPY 73
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....
gi 489513042 139 HLLVLARGPEGYRRLSRQLAAAHLAGGEKGKPRYDFDALTEAAGGHWHILTGCR 192
Cdd:cd07431 74 PLLLLAKNNEGYQNLLRLSTAAMLGEEKDGVPYLDLEELAEAASGLLVVLLGPL 127
|
|
| PHP_PolIIIA_DnaE3 |
cd12113 |
Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III ... |
61-337 |
7.58e-49 |
|
Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; PolIIIAs that contain an N-terminal PHP domain have been classified into four basic groups based on genome composition, phylogenetic, and domain structural analysis: polC, dnaE1, dnaE2, and dnaE3. The PHP (also called histidinol phosphatase-2/HIS2) domain is associated with several types of DNA polymerases, such as PolIIIA and family X DNA polymerases, stand alone histidinol phosphate phosphatases (HisPPases), and a number of uncharacterized protein families. DNA polymerase III holoenzyme is one of the five eubacterial DNA polymerases that is responsible for the replication of the DNA duplex. The alpha subunit of DNA polymerase III core enzyme catalyzes the reaction for polymerizing both DNA strands. The PolIIIA PHP domain has four conserved sequence motifs and contains an invariant histidine that is involved in metal ion coordination, and like other PHP structures, the PolIIIA PHP exhibits a distorted (beta/alpha) 7 barrel and coordinates up to 3 metals. Initially, it was proposed that PHP region might be involved in pyrophosphate hydrolysis, but such an activity has not been found. It has been shown that the PHP of PolIIIA has a trinuclear metal complex and is capable of proofreading activity. Bacterial genome replication and DNA repair mechanisms is related to the GC content of its genomes. There is a correlation between GC content variations and the dimeric combinations of PolIIIA subunits. Eubacteria can be grouped into different GC variable groups: the full-spectrum or dnaE1 group, the high-GC or dnaE2-dnaE1 group, and the low GC or polC-dnaE3 group.
Pssm-ID: 213997 [Multi-domain] Cd Length: 283 Bit Score: 175.32 E-value: 7.58e-49
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489513042 61 LHAHSAYSFLDGASTPEELVEEAARLGLCALALTDHDGLYGAVRFAEAAAELDVRTVFGAELSLGATARTERPDPPGP-- 138
Cdd:cd12113 5 LHVHTEYSLLDGAIRIKDLVKRAKELGMPALAITDHGNMFGAIEFYKAAKKAGIKPIIGCEVYVAPGSRFDKKDKKGDkr 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489513042 139 --HLLVLARGPEGYRRLSRQLAAAHLaggeKG---KPRYDFDALTEAAGGhwhI--LTGCRKGHVRQALSQGGPAAAQRA 211
Cdd:cd12113 85 yyHLVLLAKNEEGYRNLMKLVSLAYL----EGfyyKPRIDKELLAKYSEG---LiaLSACLAGEIPQLLLNGDEEEAREA 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489513042 212 LADLVDRFTPSRVSIELTHHGHPLDDERNAALAGLAPRFGVGIVAT---------------------TGAHFADPSRGRL 270
Cdd:cd12113 158 ALEYRDIFGKDNFYLELQDHGLPEQKKVNEGLIELAKELGIPLVATndvhylnkedaeahdvllciqTGKTLDDPNRMRF 237
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 489513042 271 AMAmaairarrsldsaagwlaplgGAHLRSGEEMARLFAWCPEAVTAAAELGERCAFGLQLIAPRLP 337
Cdd:cd12113 238 DTD---------------------EFYLKSPEEMRELFPDVPEALENTLEIAERCNVELDFGKLHLP 283
|
|
| PHP_PolIIIA_DnaE1 |
cd07433 |
Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III ... |
61-339 |
9.30e-47 |
|
Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE1; PolIIIAs that contain an N-terminal PHP domain have been classified into four basic groups based on genome composition, phylogenetic, and domain structural analysis: polC, dnaE1, dnaE2, and dnaE3. The PHP (also called histidinol phosphatase-2/HIS2) domain is associated with several types of DNA polymerases, such as PolIIIA and family X DNA polymerases, stand alone histidinol phosphate phosphatases (HisPPases), and a number of uncharacterized protein families. DNA polymerase III holoenzyme is one of the five eubacterial DNA polymerases that are responsible for the replication of the DNA duplex. PolIIIA core enzyme catalyzes the reaction for polymerizing both DNA strands. dnaE1 is the longest compared to dnaE2 and dnaE3. A unique motif was also identified in dnaE1 and dnaE3 genes.
Pssm-ID: 213988 [Multi-domain] Cd Length: 277 Bit Score: 169.20 E-value: 9.30e-47
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489513042 61 LHAHSAYSFLDGASTPEELVEEAARLGLCALALTDHDGLYGAVRFAEAAAELDVRTVFGAELSLgatARTERPDPPGpHL 140
Cdd:cd07433 5 LRVHSEYSLLDGAVRIKKLVKLAKEDGMPALAITDLSNLFGAVKFYKAASKAGIKPIIGADLNV---ANPDDADEPF-RL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489513042 141 LVLARGPEGYRRLSRQLAAAHLAGGEKGKPRYDFDALTEAAGGhWHILTGCRKGHVRQALSQGGPAAAQRALADLVDRFt 220
Cdd:cd07433 81 TLLAQNEQGYKNLTELISRAYLEGQRNGGPHIKLEWLAEYSEG-LIALSGGRDGDIGQLLLEGNPDLAEALLQFLKKIF- 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489513042 221 PSRVSIELTHHGHPLDDERNAALAGLAPRFGVGIVATTGAHFADPS------------RGRLamamaairarrsLDSAAG 288
Cdd:cd07433 159 PDRFYLELQRHGRPEEEAYEHALIDLAYELGLPLVATNDVRFLKPEdfeahearvciaEGRT------------LDDPRR 226
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|.
gi 489513042 289 WLAPLGGAHLRSGEEMARLFAWCPEAVTAAAELGERCAFGLQLIAPRLPPF 339
Cdd:cd07433 227 PRRYSPQQYFKSAEEMAELFADLPEAIENTVEIAKRCNVRIELGKPFLPDF 277
|
|
| PHP |
pfam02811 |
PHP domain; The PHP (Polymerase and Histidinol Phosphatase) domain is a putative ... |
60-231 |
1.05e-38 |
|
PHP domain; The PHP (Polymerase and Histidinol Phosphatase) domain is a putative phosphoesterase domain.
Pssm-ID: 460705 [Multi-domain] Cd Length: 171 Bit Score: 141.91 E-value: 1.05e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489513042 60 ELHAHSAYSFLDGASTPEELVEEAARLGLCALALTDHDGLYGAVRFAEAAAELDVRTVFGAELSLGATARTERP--DPPG 137
Cdd:pfam02811 1 HLHVHSEYSLLDGAARIEELVKRAKELGMPAIAITDHGNLFGAVEFYKAAKKAGIKPIIGCEVYVAPGSREETEklLAKY 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489513042 138 PHLLVLARGPEGYRRLSRQLAAAHLAGgekGKPRYDFDALTEAAGGhWHILTGCRKGHVRQAL-SQGGPAAAQRALADLV 216
Cdd:pfam02811 81 FDLVLLAVHEVGYKNLIKLSSRAYLEG---FKPRIDKELLEEYFEG-LIALSGCVLGHLDLILlAPGDYEEAEELAEEYL 156
|
170
....*....|....*
gi 489513042 217 DRFTPSRVSIELTHH 231
Cdd:pfam02811 157 EIFGEDGFYLEINTH 171
|
|
| HHH_6 |
pfam14579 |
Helix-hairpin-helix motif; The HHH domain is a short DNA-binding domain. |
837-924 |
4.49e-24 |
|
Helix-hairpin-helix motif; The HHH domain is a short DNA-binding domain.
Pssm-ID: 434050 [Multi-domain] Cd Length: 88 Bit Score: 97.16 E-value: 4.49e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489513042 837 GVAVHGPCVNASLAHATCENAGteVRLGLGAVRYLGAELAEKLVAERtANGPFTSLPDLTSRVQLSVP--QVEALATAGA 914
Cdd:pfam14579 1 GIEVLPPDINRSDWDFTVEGGG--IRLGLGAIKGLGEAAAERIVEER-ENGPFKSLEDFARRVDLKLNkrVLEALIKAGA 77
|
90
....*....|
gi 489513042 915 LGCFGMSRRE 924
Cdd:pfam14579 78 FDSLGGNRRQ 87
|
|
| POLIIIAc |
smart00481 |
DNA polymerase alpha chain like domain; DNA polymerase alpha chain like domain, incl. family ... |
60-124 |
1.79e-21 |
|
DNA polymerase alpha chain like domain; DNA polymerase alpha chain like domain, incl. family of hypothetical proteins
Pssm-ID: 197753 [Multi-domain] Cd Length: 67 Bit Score: 88.86 E-value: 1.79e-21
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 489513042 60 ELHAHSAYSFLDGASTPEELVEEAARLGLCALALTDHDGLYGAVRFAEAAAELDVRTVFGAELSL 124
Cdd:smart00481 1 DLHVHSDYSLLDGALSPEELVKRAKELGLKAIAITDHGNLFGAVEFYKAAKKAGIKPIIGLEANI 65
|
|
| YciV |
COG0613 |
5'-3' exoribonuclease TrpH/YciV (RNase AM), contains PHP domain [Nucleotide transport and ... |
58-264 |
6.70e-18 |
|
5'-3' exoribonuclease TrpH/YciV (RNase AM), contains PHP domain [Nucleotide transport and metabolism];
Pssm-ID: 440378 [Multi-domain] Cd Length: 188 Bit Score: 82.65 E-value: 6.70e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489513042 58 YAELHAHSAYSflDGASTPEELVEEAARLGLCALALTDHDGLYGAVRFAEAAAELDVRTVFGAELSlgatarTERPDPPg 137
Cdd:COG0613 3 KIDLHVHTTAS--DGSLSPEELVARAKAAGLDVLAITDHDTVAGYEEAAEAAKELGLLVIPGVEIS------TRWEGRE- 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489513042 138 PHLLVLargpeGYRRLSRQLAAahLAGGEKGKPRYDFDALTEAagghwhiltgcrkghVRQALSQGG------PAAAQR- 210
Cdd:COG0613 74 VHILGY-----GIDPEDPALEA--LLGIPVEKAEREWLSLEEA---------------IDLIREAGGvavlahPFRYKRg 131
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*.
gi 489513042 211 -ALADLVDRFTPSRVS-IELTHHGHplDDERNAALAGLAPRFGVGIVATTGAHFAD 264
Cdd:COG0613 132 rWLDDLLEELADAGLDgIEVYNGRH--SPEDNERAAELAEEYGLLATGGSDAHGPE 185
|
|
| PHP_HisPPase_AMP |
cd07438 |
Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) ... |
61-123 |
6.40e-16 |
|
Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; The PHP domain of this HisPPase family has an unknown function. It has a second domain inserted in the middle that binds adenosine 5-monophosphate (AMP). The PHP (also called histidinol phosphatase-2/HIS2) domain is associated with several types of DNA polymerases, such as PolIIIA and family X DNA polymerases, stand alone histidinol phosphate phosphatases (HisPPases), and a number of uncharacterized protein families. HisPPase catalyzes the eighth step of histidine biosynthesis, in which L-histidinol phosphate undergoes dephosphorylation to give histidinol. The PHP domain has four conserved sequence motifs and contains an invariant histidine that is involved in metal ion coordination. The PHP domain of HisPPase is structurally homologous to the other members of the PHP family that have a distorted (beta/alpha)7 barrel fold with a trinuclear metal site on the C-terminal side of the barrel.
Pssm-ID: 213993 [Multi-domain] Cd Length: 155 Bit Score: 75.89 E-value: 6.40e-16
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 489513042 61 LHAHSAYSflDGASTPEELVEEAARLGLCALALTDHDGLYGAVRFAEAAAELDVRTVFGAELS 123
Cdd:cd07438 3 LHTHSTAS--DGTLSPEELVELAKEAGLKVLAITDHDTVAGLEEALAAAKELGIELIPGVEIS 63
|
|
| DnaE_OBF |
cd04485 |
DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding ... |
1005-1076 |
1.23e-15 |
|
DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains two copies of this replicative polymerase, each of which copies a different DNA strand. This group also contains Bacillus subtilis DnaE. Replication in B. subtilis and Staphylococcus aureus requires two different type C polymerases, polC and DnaE, both of which are thought to be included in the DNA polymerase holoenzyme. At the B. subtilis replication fork, polC appears to be involved in leading strand synthesis and DnaE in lagging strand synthesis.
Pssm-ID: 239931 [Multi-domain] Cd Length: 84 Bit Score: 72.93 E-value: 1.23e-15
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 489513042 1005 LIAGAVTHRQRPATAQG--VTFINLEDETGMVNVLCTPGVWARHRKLAHTAPALLIRGQVQNASGAITVVAERM 1076
Cdd:cd04485 1 TVAGLVTSVRRRRTKKGkrMAFVTLEDLTGSIEVVVFPETYEKYRDLLKEDALLLVEGKVERRDGGLRLIAERI 74
|
|
| PHP_PolIIIA_POLC |
cd07435 |
Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at ... |
60-310 |
2.02e-13 |
|
Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at PolC gene; DNA polymerase III alphas (PolIIIAs) that contain a PHP domain have been classified into four basic groups based on phylogenetic and domain structural analyses: polC, dnaE1, dnaE2, and dnaE3. The PolC group is distinct from the other three and is clustered together. The PHP (also called histidinol phosphatase-2/HIS2) domain is associated with several types of DNA polymerases, such as PolIIIA and family X DNA polymerases, stand alone histidinol phosphate phosphatases (HisPPases), and a number of uncharacterized protein families. DNA polymerase III holoenzyme is one of the five eubacterial DNA polymerases that are responsible for the replication of the DNA duplex. The alpha subunit of DNA polymerase III core enzyme catalyzes the reaction for polymerizing both DNA strands. PolC PHP is located in different location compare to dnaE1, 2, and 3. The PHP domain has four conserved sequence motifs and and contains an invariant histidine that is involved in metal ion coordination.The PHP domain of PolC is structurally homologous to other members of the PHP family that have a distorted (beta/alpha)7 barrel fold with a trinuclear metal site on the C-terminal side of the barrel. PHP domains found in dnaEs of thermophilic origin exhibit 3'-5' exonuclease activity. In contrast, PolC PHP lacks detectable nuclease activity.
Pssm-ID: 213990 [Multi-domain] Cd Length: 268 Bit Score: 71.74 E-value: 2.02e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489513042 60 ELHAHSAYSFLDGASTPEELVEEAARLGLCALALTDHDGLYGAVRFAEAAAELDVRTVFGAELSLgatarterPDPpgPH 139
Cdd:cd07435 3 ELHAHTKMSAMDGVTSVKELVKRAAEWGHKAIAITDHGVVQAFPEAYEAAKKNGIKVIYGVEAYL--------VDP--YH 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489513042 140 LLVLARGPEGYRRLSRQLAAAHLaggE--KGKPRYDFDALTEAAGGhwhIL--TGCRKGHVRQALSQGGPAAAQRALADL 215
Cdd:cd07435 73 ITILVKNQTGLKNLYKLVSLSHT---KyfYRVPRIPKSELEKYREG---LLigSACENGELFEAALNKKSDEELEEIASF 146
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489513042 216 VDRFT--PSRVSIELTHHGHPLDDER----NAALAGLAPRFGVGIVATTGAHFADPS----RGRLAMAMAAIrarrslDS 285
Cdd:cd07435 147 YDYIEiqPLDNYQFLIEKGLIKSEEElkeiNKRIIKLGKKLNKPVVATGDVHYLDPEdkiyREILLAGQGGG------DG 220
|
250 260
....*....|....*....|....*
gi 489513042 286 AAGWLAPLggaHLRSGEEMARLFAW 310
Cdd:cd07435 221 RADEQPDL---YFRTTDEMLDEFSY 242
|
|
| PHP_HisPPase |
cd07432 |
Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase; HisPPase ... |
59-124 |
4.70e-13 |
|
Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase; HisPPase catalyzes the eighth step of histidine biosynthesis, in which L-histidinol phosphate undergoes dephosphorylation to produce histidinol. HisPPase can be classified into two types: the bifunctional HisPPase found in proteobacteria that belongs to the DDDD superfamily and the monofunctional Bacillus subtilis type that is a member of the PHP family. The PHP (also called histidinol phosphatase-2/HIS2) domain is associated with several types of DNA polymerases, such as PolIIIA and family X DNA polymerases, stand alone histidinol phosphate phosphatases (HisPPases), and a number of uncharacterized protein families. The PHP domain has four conserved sequence motifs and contains an invariant histidine that is involved in metal ion coordination. The PHP domain of HisPPase is structurally homologous to other members of the PHP family that have a distorted (beta/alpha)7 barrel fold with a trinuclear metal site on the C-terminal side of the barrel.
Pssm-ID: 213987 [Multi-domain] Cd Length: 129 Bit Score: 66.88 E-value: 4.70e-13
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 489513042 59 AELHAHSAYSFlDGASTPEELVEEAARLGLCALALTDHDGLYGAVRFAEAAAELDVRTVFGAELSL 124
Cdd:cd07432 1 ADLHIHSVFSP-DSDMTPEEIVERAIELGLDGIAITDHNTIDGAEEALKEAYKDGLLVIPGVEVTL 65
|
|
| polC_Gram_pos |
TIGR01405 |
DNA polymerase III, alpha chain, Gram-positive type; This model describes a polypeptide chain ... |
187-816 |
3.48e-12 |
|
DNA polymerase III, alpha chain, Gram-positive type; This model describes a polypeptide chain of DNA polymerase III. Full-length homologs of this protein are restricted to the Gram-positive lineages, including the Mycoplasmas. This protein is designated alpha chain and given the gene symbol polC, but is not a full-length homolog of other polC genes. The N-terminal region of about 200 amino acids is rich in low-complexity sequence, poorly alignable, and not included n this model. [DNA metabolism, DNA replication, recombination, and repair]
Pssm-ID: 273601 [Multi-domain] Cd Length: 1213 Bit Score: 70.87 E-value: 3.48e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489513042 187 ILTGCRKGHVRQALSQGGPAAAQRaLADLVDRFT--PSRVSIELTHHGHPLDDER----NAALAGLAPRFGVGIVATTGA 260
Cdd:TIGR01405 429 IGSACSEGELFDALLSKPDDELEE-IAKRYDFIEiqPPGNYAHLIEREQVKDKEAlkeiIKKLIELAKELNKPVVATGDV 507
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489513042 261 HFADPSRGRLAMAMAAIRARRSLDSAAGWLAPLGGAHLRSGEEMARLFAWCPE------AVTAAAELGERCAfGLQLIAP 334
Cdd:TIGR01405 508 HYIEPEDKIYRKILVASQGLGNPLNRHFNPKEVPELHFRTTNEMLDEFSFLGEekayeiVVENTNKIADQIE-EIQPIKD 586
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489513042 335 RL-PPFdvPDGHTEDswLRSLVMAGARERYGPPksAPRAYSQ-IEHELKVIAQLRFPGYFLVVHDITRFCRDNDILCQGR 412
Cdd:TIGR01405 587 KLyTPK--IEGADEK--IRDLTYENAKKIYGDP--LPEIVEQrIEKELKSIIGNGFAVIYLISQLLVQKSLQDGYLVGSR 660
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489513042 413 GSAANSAVCYALGVTAVDPVANELL-----------------------------------------FERFLSPARDGPPD 451
Cdd:TIGR01405 661 GSVGSSLVATMTGITEVNPLPPHYLcpnckysefitdgsvgsgfdlpdkdcpkcgaplkkdgqdipFETFLGFKGDKVPD 740
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489513042 452 IDIDIESDQREKVIQYVYHKYGRDYAAQVANVITYRGRSAVrdmaralGFSPGQQDAWSKQVSHwtgqaddvdgipEQVI 531
Cdd:TIGR01405 741 IDLNFSGEYQAKAHNYVKELFGEDHTFRAGTIGTVAEKTAY-------GYVKKYFEDQGKHYRD------------AEIE 801
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489513042 532 DLATQIRNLPRHLGIHSGGMVIC--DRPIADVCPVEWArmANRSVLQWDKD--DCAAIG--LVKFDLLGLGMLSALHYAK 605
Cdd:TIGR01405 802 RLVQGCTGVKRTTGQHPGGIIIVpkYMDVYDFTPVQYP--ADDTNSDWKTThfDFHSIHdnLLKLDILGHDDPTMIKMLQ 879
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489513042 606 DLVaehkGIEV-DLARLDlsePAVYEMLARADSVGV--FQVESRAQMATLPRL------------KPRVFYDLVVEVALI 670
Cdd:TIGR01405 880 DLT----GIDPkTIPMDD---KEVMSIFSSPKALGVtpEEILEKTGTLGIPEFgtkfvrgmleetKPKTFADLVRISGLS 952
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489513042 671 RPGPIQGGSVHPYIRRRNG-VDPVIyehpsmapALRKTLGVPLFQEQL-MQLAvdcagFSAAEadQLRRAMGSKrstERM 748
Cdd:TIGR01405 953 HGTDVWLGNAQDLIKSGIKtLSDVI--------GCRDDIMVYLIHKGLePKLA-----FKIME--KVRKGKGLK---AEY 1014
|
650 660 670 680 690 700
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 489513042 749 RRLrgrfydgMRAlHGAPDEVIDRIyEKLEafanFGFPESHALSFASLVFYSAWFKLHHPAAFCAALL 816
Cdd:TIGR01405 1015 IEL-------MKE-NKVPEWYIESC-LKIK----YMFPKAHAAAYVLMAWRIAYFKVHYPLEYYAAYF 1069
|
|
| PRK07373 |
PRK07373 |
DNA polymerase III subunit alpha; Reviewed |
785-915 |
1.02e-10 |
|
DNA polymerase III subunit alpha; Reviewed
Pssm-ID: 236003 [Multi-domain] Cd Length: 449 Bit Score: 65.47 E-value: 1.02e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489513042 785 FPESHALSFASLVFYSAWFKLHHPAAFCAALLRAQPMGFYSPQSLVADARRHGVAVHGPCVNASLAHATceNAGTEVRLG 864
Cdd:PRK07373 38 FNKSHSTAYAYVTYQTAYLKANYPVEYMAALLTANSGNQDKVQKYRENCQKMGIEVEPPDINRSGKDFT--PVGEKILFG 115
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....
gi 489513042 865 LGAVRYLGAELAEKLVAERTANGPFTSLPDLTSRVQLSVPQ---VEALATAGAL 915
Cdd:PRK07373 116 LSAVRNLGEGAIESILKAREEGGEFKSLADFCDRVDLRVVNrraLETLIYCGAF 169
|
|
| polC |
PRK00448 |
DNA polymerase III PolC; Validated |
47-124 |
4.13e-10 |
|
DNA polymerase III PolC; Validated
Pssm-ID: 234767 [Multi-domain] Cd Length: 1437 Bit Score: 64.47 E-value: 4.13e-10
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 489513042 47 PGRERVgssvayaELHAHSAYSFLDGASTPEELVEEAARLGLCALALTDHDGLYGAVRFAEAAAELDVRTVFGAELSL 124
Cdd:PRK00448 330 EEEKRV-------ELHLHTKMSTMDAIPSVSELVKRAAKWGHKAIAITDHGVVQAFPEAYNAAKKAGIKVIYGVEANL 400
|
|
| HIS2 |
COG1387 |
Histidinol phosphatase or related hydrolase of the PHP family [Amino acid transport and ... |
61-104 |
6.23e-07 |
|
Histidinol phosphatase or related hydrolase of the PHP family [Amino acid transport and metabolism, General function prediction only]; Histidinol phosphatase or related hydrolase of the PHP family is part of the Pathway/BioSystem: Histidine biosynthesis
Pssm-ID: 440997 [Multi-domain] Cd Length: 232 Bit Score: 51.69 E-value: 6.23e-07
10 20 30 40
....*....|....*....|....*....|....*....|....*
gi 489513042 61 LHAHSAYSflDGASTPEELVEEAARLGLCALALTDH-DGLYGAVR 104
Cdd:COG1387 5 LHTHTTYS--DGEGTIEEMVEAAIELGLEYIAITDHsPSLFVANG 47
|
|
| PHP |
cd07309 |
Polymerase and Histidinol Phosphatase domain; The PHP (also called histidinol phosphatase-2 ... |
59-124 |
1.46e-06 |
|
Polymerase and Histidinol Phosphatase domain; The PHP (also called histidinol phosphatase-2/HIS2) domain is associated with several types of DNA polymerases, such as PolIIIA and family X DNA polymerases, stand alone histidinol phosphate phosphatases (HisPPases), and a number of uncharacterized protein families. The PHP domain has four conserved sequence motifs and contains an invariant histidine that is involved in metal ion coordination. PHP in polymerases has trinuclear zinc/magnesium dependent proofreading activity. It has also been shown that the PHP domain functions in DNA repair. The PHP structures have a distorted (beta/alpha)7 barrel fold with a trinuclear metal site on the C-terminal side of the barrel.
Pssm-ID: 213985 [Multi-domain] Cd Length: 88 Bit Score: 47.42 E-value: 1.46e-06
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 489513042 59 AELHAHSAYSFLDgASTPEELVEEAARLGLCALALTDHDGLYGAVRF--------AEAAAELDVRTVFGAELSL 124
Cdd:cd07309 1 VDLHTHTVFSDGD-HAKLTELVDKAKELGPDALAITDHGNLRGLAEFntagk*nhIKAAEAAGIKIIIGSEVNL 73
|
|
| tRNA_anti-codon |
pfam01336 |
OB-fold nucleic acid binding domain; This family contains OB-fold domains that bind to nucleic ... |
1004-1076 |
6.88e-06 |
|
OB-fold nucleic acid binding domain; This family contains OB-fold domains that bind to nucleic acids. The family includes the anti-codon binding domain of lysyl, aspartyl, and asparaginyl -tRNA synthetases (See pfam00152). Aminoacyl-tRNA synthetases catalyze the addition of an amino acid to the appropriate tRNA molecule EC:6.1.1.-. This family also includes part of RecG helicase involved in DNA repair. Replication factor A is a hetero-trimeric complex, that contains a subunit in this family. This domain is also found at the C-terminus of bacterial DNA polymerase III alpha chain.
Pssm-ID: 460164 [Multi-domain] Cd Length: 75 Bit Score: 44.92 E-value: 6.88e-06
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 489513042 1004 VLIAGAVTHRQRpaTAQGVTFINLEDETGMVNVLCTPGVWARHRKLAHTAPALLIRGQVQNASGA-ITVVAERM 1076
Cdd:pfam01336 1 VTVAGRVTSIRR--SGGKLLFLTLRDGTGSIQVVVFKEEAEKLAKKLKEGDVVRVTGKVKKRKGGeLELVVEEI 72
|
|
| PHP_HisPPase_Chlorobi_like |
cd12112 |
Polymerase and Histidinol Phosphatase domain of Chlorobi like; The PHP (also called histidinol ... |
45-140 |
1.31e-05 |
|
Polymerase and Histidinol Phosphatase domain of Chlorobi like; The PHP (also called histidinol phosphatase-2/HIS2) domain is associated with several types of DNA polymerases, such as PolIIIA and family X DNA polymerases, stand alone histidinol phosphate phosphatases (HisPPases), and a number of uncharacterized protein families. Chlorobi PHP is uncharacterized protein. HisPPase catalyzes the eighth step of histidine biosynthesis, in which L-histidinol phosphate undergoes dephosphorylation to produce histidinol. The HisPPase can be classified into two types: the bifunctional Hisppase found in proteobacteria that belongs to the DDDD superfamily and the monofunctional Bacillus subtilis type that is a member of the PHP family. The PHP domain has four conserved sequence motifs and contains an invariant histidine that is involved in metal ion coordination. The PHP domain of HisPPase is structurally homologous to other members of the PHP family that have a distorted (beta/alpha)7 barrel fold with a trinuclear metal site on the C-terminal side of the barrel.
Pssm-ID: 213996 [Multi-domain] Cd Length: 235 Bit Score: 47.71 E-value: 1.31e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489513042 45 QPPGRErvGSSVAYAELHAHSAYSflDGASTPEELVEEAARLGLCALALTDH--------DGLYG----AVRFA-EAAAE 111
Cdd:cd12112 3 QVPDIP--GYKTLKCDFHTHTVFS--DGHVWPEIRVREAWREGLDAIAITEHieyrphkeDIPHPdrnrSYKIAkEAAES 78
|
90 100
....*....|....*....|....*....
gi 489513042 112 LDVRTVFGAELSlgatarteRPDPPGpHL 140
Cdd:cd12112 79 KGLLIIPGAEIT--------REKPPG-HL 98
|
|
| CehA_McbA_metalo |
NF038032 |
CehA/McbA family metallohydrolase domain; This domain, a branch of the PHP superfamily, is ... |
59-123 |
3.79e-05 |
|
CehA/McbA family metallohydrolase domain; This domain, a branch of the PHP superfamily, is found in several partially characterized metallohydrolases, including McbA and CehA. Both were studied as hydrolases of carbaryl, a xenobiotic compound that does not contain a phosphate group, suggesting that presuming members of this family to be phosphoesterases (like many PHP domain-containing proteins) may be incorrect.
Pssm-ID: 468321 [Multi-domain] Cd Length: 315 Bit Score: 46.93 E-value: 3.79e-05
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 489513042 59 AELHAHSAYSflDGASTPEELVEEAARLGLCALALTDHDGLYGAVRFAEA-AAELDVRTVFGAELS 123
Cdd:NF038032 5 GDLHIHTNHS--DGPTTPEELARAALAEGLDVIALTDHNTISGRAYFAELlASERGLLVIPGMEVT 68
|
|
| PHP_PolX |
cd07436 |
Polymerase and Histidinol Phosphatase domain of bacterial polymerase X; The bacterial/archaeal ... |
61-96 |
4.11e-05 |
|
Polymerase and Histidinol Phosphatase domain of bacterial polymerase X; The bacterial/archaeal X-family DNA polymerases (PolXs) have a PHP domain at their C-terminus. The bacterial/archaeal PolX core domain and PHP domain interact with each other and together are involved in metal dependent 3'-5' exonuclease activity. The PHP (also called histidinol phosphatase-2/HIS2) domain is associated with several types of DNA polymerases, such as PolIIIA and family X DNA polymerases, stand alone histidinol phosphate phosphatases (HisPPases), and a number of uncharacterized protein families. The PHP domain has four conserved sequence motifs and contains an invariant histidine that is involved in metal ion coordination. PolX is found in all kingdoms, however bacterial PolXs have a completely different domain structure from eukaryotic PolXs. Bacterial PolX has an extended conformation in contrast to the common closed 'right hand' conformation for DNA polymerases. This extended conformation is stabilized by the PHP domain. The PHP domain of PolX is structurally homologous to other members of the PHP family that has a distorted (beta/alpha)7 barrel fold with a trinuclear metal site on the C-terminal side of the barrel.
Pssm-ID: 213991 [Multi-domain] Cd Length: 237 Bit Score: 46.26 E-value: 4.11e-05
10 20 30
....*....|....*....|....*....|....*.
gi 489513042 61 LHAHSAYSflDGASTPEELVEEAARLGLCALALTDH 96
Cdd:cd07436 9 LHVHTTWS--DGRNSIEEMAEAARALGYEYIAITDH 42
|
|
| PRK07945 |
PRK07945 |
PHP domain-containing protein; |
21-96 |
4.67e-04 |
|
PHP domain-containing protein;
Pssm-ID: 236135 [Multi-domain] Cd Length: 335 Bit Score: 43.81 E-value: 4.67e-04
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 489513042 21 PRHAGVPAFDADGDVP--RSRKRGAYQPPGRERVGSSVAyAELHAHSAYSflDGASTPEELVEEAARLGLCALALTDH 96
Cdd:PRK07945 59 PKTAKVIAQALAGRVPdyLAELRADAEPLGGGALRAALR-GDLHTHSDWS--DGGSPIEEMARTAAALGHEYCALTDH 133
|
|
| ComEA |
COG1555 |
DNA uptake protein ComE or related DNA-binding protein [Replication, recombination and repair]; ... |
865-909 |
1.15e-03 |
|
DNA uptake protein ComE or related DNA-binding protein [Replication, recombination and repair];
Pssm-ID: 441164 [Multi-domain] Cd Length: 72 Bit Score: 38.69 E-value: 1.15e-03
10 20 30 40
....*....|....*....|....*....|....*....|....*
gi 489513042 865 LGAVRYLGAELAEKLVAERTANGPFTSLPDLTSRVQLSVPQVEAL 909
Cdd:COG1555 23 LQTLPGIGPKLAQRIVEYREKNGPFKSVEDLLEVKGIGPKTLEKL 67
|
|
| PHP_HisPPase_Ycdx_like |
cd07437 |
Polymerase and Histidinol Phosphatase domain of Ycdx like; PHP Ycdx-like is a stand alone PHP ... |
59-96 |
2.15e-03 |
|
Polymerase and Histidinol Phosphatase domain of Ycdx like; PHP Ycdx-like is a stand alone PHP domain similar to Ycdx E. coli protein with an unknown physiological role. The PHP (also called histidinol phosphatase-2/HIS2) domain is associated with several types of DNA polymerases, such as PolIIIA and family X DNA polymerases, stand alone histidinol phosphate phosphatases (HisPPases), and a number of uncharacterized protein families. The PHP domain has four conserved sequence motifs and contains an invariant histidine that is involved in metal ion coordination. It has also been shown that the PHP domain functions in DNA repair. The PHP structures have a distorted (beta/alpha)7 barrel fold with a trinuclear metal site on the C-terminal side of the barrel. YcdX may be involved in swarming.
Pssm-ID: 213992 [Multi-domain] Cd Length: 233 Bit Score: 40.89 E-value: 2.15e-03
10 20 30 40
....*....|....*....|....*....|....*....|...
gi 489513042 59 AELHAHS-----AYSfldgasTPEELVEEAARLGLCALALTDH 96
Cdd:cd07437 3 ADLHTHTiasghAYS------TIEEMARAAAEKGLKLLGITDH 39
|
|
| HHH_3 |
pfam12836 |
Helix-hairpin-helix motif; The HhH domain is a short DNA-binding domain. |
865-895 |
5.20e-03 |
|
Helix-hairpin-helix motif; The HhH domain is a short DNA-binding domain.
Pssm-ID: 463723 [Multi-domain] Cd Length: 62 Bit Score: 36.31 E-value: 5.20e-03
10 20 30
....*....|....*....|....*....|.
gi 489513042 865 LGAVRYLGAELAEKLVAERTANGPFTSLPDL 895
Cdd:pfam12836 14 LSRVPGLGPKLAKNIVEYREENGPFRSREDL 44
|
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