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Conserved domains on  [gi|489508130|ref|WP_003412998|]
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MULTISPECIES: B-4DMT family transporter [Mycobacterium]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
B-4DMT NF037996
B-4DMT family transporter;
1-138 1.22e-53

B-4DMT family transporter;


:

Pssm-ID: 468305  Cd Length: 139  Bit Score: 168.98  E-value: 1.22e-53
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489508130   1 MTNWMLRGLAFAAAMVVLRLFQGALINAWQMLSGLISLVLLLLFAIGGVVWGVMDGRADAKASPDPDRRQDLAMTWLLAG 80
Cdd:NF037996   1 MSAWLLRGLVMAAVHVVVRVLLGAAIVAWPTQGSLIRWLALAVVVLAALVWGGLDGRRDARANPDPDRREDLTMTWLKAG 80

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 489508130  81 LVAGALSGAVAWLISLFYKA-IYTGGPINELTTFAAFTALIVFLVGIVGVAVGRWLVDR 138
Cdd:NF037996  81 LVAGVVSGLVAWIIGLFYVDgLGVNGLFFELTTGAAFTALLVFVPAGIGVALGRFLVDR 139
 
Name Accession Description Interval E-value
B-4DMT NF037996
B-4DMT family transporter;
1-138 1.22e-53

B-4DMT family transporter;


Pssm-ID: 468305  Cd Length: 139  Bit Score: 168.98  E-value: 1.22e-53
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489508130   1 MTNWMLRGLAFAAAMVVLRLFQGALINAWQMLSGLISLVLLLLFAIGGVVWGVMDGRADAKASPDPDRRQDLAMTWLLAG 80
Cdd:NF037996   1 MSAWLLRGLVMAAVHVVVRVLLGAAIVAWPTQGSLIRWLALAVVVLAALVWGGLDGRRDARANPDPDRREDLTMTWLKAG 80

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 489508130  81 LVAGALSGAVAWLISLFYKA-IYTGGPINELTTFAAFTALIVFLVGIVGVAVGRWLVDR 138
Cdd:NF037996  81 LVAGVVSGLVAWIIGLFYVDgLGVNGLFFELTTGAAFTALLVFVPAGIGVALGRFLVDR 139
ABC_6TM_Pgp_ABCB1_D2_like cd18578
Six-transmembrane helical domain 2 (TMD2) of P-glycoprotein 1 (Pgp) and related proteins; ...
 76-127 3.07e-03

Six-transmembrane helical domain 2 (TMD2) of P-glycoprotein 1 (Pgp) and related proteins; P-glycoprotein 1 (permeability glycoprotein, Pgp) also known as multidrug resistance protein 1 (MDR1) or ATP-binding cassette sub-family B member 1 (ABCB1) is a member of the superfamily of ATP-binding cassette (ABC) transporters. Pgp acts as an ATP-dependent efflux pump, binds drugs with diverse chemical structures and pump them out of the drug resistant cancer cells. It is responsible for decreased drug accumulation in multidrug-resistant cells and mediates the development of resistance to anticancer drugs. Pgp consists of two alpha-helical transmembrane domains (TMDs) and two cytoplasmic nucleotide-binding domains (NBDs). This protein also functions as a transporter in the blood-brain barrier. In addition to Pgp, breast cancer resistance protein (BCRP/MXR/ABC-P/ABCG2) and multidrug resistance-associated proteins (MRP1/ABCC1 and MRP2/ABCC2) function as drug efflux pumps of anticancer drugs, and overexpression of these transporters induces multidrug resistance to a broad spectrum of anticancer drugs including doxorubicin, taxol, and vinca alkaloids by actively pumping the drugs out of cells.


Pssm-ID: 350022 [Multi-domain]  Cd Length: 317  Bit Score: 37.82  E-value: 3.07e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 489508130  76 WLLAGLVAGALSGAV----AWLISLFYKAIYTGGPiNELTTFAAFTALIVFLVGIV 127
Cdd:cd18578   10 LLLLGLIGAIIAGAVfpvfAILFSKLISVFSLPDD-DELRSEANFWALMFLVLAIV 64
 
Name Accession Description Interval E-value
B-4DMT NF037996
B-4DMT family transporter;
1-138 1.22e-53

B-4DMT family transporter;


Pssm-ID: 468305  Cd Length: 139  Bit Score: 168.98  E-value: 1.22e-53
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489508130   1 MTNWMLRGLAFAAAMVVLRLFQGALINAWQMLSGLISLVLLLLFAIGGVVWGVMDGRADAKASPDPDRRQDLAMTWLLAG 80
Cdd:NF037996   1 MSAWLLRGLVMAAVHVVVRVLLGAAIVAWPTQGSLIRWLALAVVVLAALVWGGLDGRRDARANPDPDRREDLTMTWLKAG 80

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 489508130  81 LVAGALSGAVAWLISLFYKA-IYTGGPINELTTFAAFTALIVFLVGIVGVAVGRWLVDR 138
Cdd:NF037996  81 LVAGVVSGLVAWIIGLFYVDgLGVNGLFFELTTGAAFTALLVFVPAGIGVALGRFLVDR 139
ABC_6TM_Pgp_ABCB1_D2_like cd18578
Six-transmembrane helical domain 2 (TMD2) of P-glycoprotein 1 (Pgp) and related proteins; ...
 76-127 3.07e-03

Six-transmembrane helical domain 2 (TMD2) of P-glycoprotein 1 (Pgp) and related proteins; P-glycoprotein 1 (permeability glycoprotein, Pgp) also known as multidrug resistance protein 1 (MDR1) or ATP-binding cassette sub-family B member 1 (ABCB1) is a member of the superfamily of ATP-binding cassette (ABC) transporters. Pgp acts as an ATP-dependent efflux pump, binds drugs with diverse chemical structures and pump them out of the drug resistant cancer cells. It is responsible for decreased drug accumulation in multidrug-resistant cells and mediates the development of resistance to anticancer drugs. Pgp consists of two alpha-helical transmembrane domains (TMDs) and two cytoplasmic nucleotide-binding domains (NBDs). This protein also functions as a transporter in the blood-brain barrier. In addition to Pgp, breast cancer resistance protein (BCRP/MXR/ABC-P/ABCG2) and multidrug resistance-associated proteins (MRP1/ABCC1 and MRP2/ABCC2) function as drug efflux pumps of anticancer drugs, and overexpression of these transporters induces multidrug resistance to a broad spectrum of anticancer drugs including doxorubicin, taxol, and vinca alkaloids by actively pumping the drugs out of cells.


Pssm-ID: 350022 [Multi-domain]  Cd Length: 317  Bit Score: 37.82  E-value: 3.07e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 489508130  76 WLLAGLVAGALSGAV----AWLISLFYKAIYTGGPiNELTTFAAFTALIVFLVGIV 127
Cdd:cd18578   10 LLLLGLIGAIIAGAVfpvfAILFSKLISVFSLPDD-DELRSEANFWALMFLVLAIV 64
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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