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Conserved domains on  [gi|489507749|ref|WP_003412618|]
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MULTISPECIES: molybdenum cofactor guanylyltransferase [Mycobacterium]

Protein Classification

molybdenum cofactor guanylyltransferase( domain architecture ID 10792030)

molybdenum cofactor guanylyltransferase catalyzes the guanylation of the molybdenum cofactor

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PRK00576 PRK00576
molybdopterin-guanine dinucleotide biosynthesis protein A; Provisional
 24-201 7.48e-101

molybdopterin-guanine dinucleotide biosynthesis protein A; Provisional


:

Pssm-ID: 234798  Cd Length: 178  Bit Score: 289.01  E-value: 7.48e-101
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489507749  24 MGRDKATLPLPGGTTTLVEHMVGILGQRCAPVFVMAAPGQPLPTLPVPVLRDELPGLGPLPATGRGLRAAAEAGVRLAFV 103
Cdd:PRK00576   1 MGRDKATLPLPGGTTTLVEHVVGIVGQRCAPVFVMAAPGQPLPELPAPVLRDELRGLGPLPATGRGLRAAAEAGARLAFV 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489507749 104 CAVDMPYLTVELIEDLARRAVQTDAEVVLPWDGRNHYLAAVYRTDLADRVDTLVGAGERKMSALVDASDALRIVMADSRP 183
Cdd:PRK00576  81 CAVDMPYLTVELIDDLARPAAQTDAEVVLPWDGRDHYLAAVYRTDLAERVDALVGAGERSMRALVDASDAQRIVMPESRP 160

                        170
                 ....*....|....*...
gi 489507749 184 LTNVNSAAGLHAPMQPGR 201
Cdd:PRK00576 161 LTNVNTAADLPAPMQPGR 178
 
Name Accession Description Interval E-value
PRK00576 PRK00576
molybdopterin-guanine dinucleotide biosynthesis protein A; Provisional
 24-201 7.48e-101

molybdopterin-guanine dinucleotide biosynthesis protein A; Provisional


Pssm-ID: 234798  Cd Length: 178  Bit Score: 289.01  E-value: 7.48e-101
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489507749  24 MGRDKATLPLPGGTTTLVEHMVGILGQRCAPVFVMAAPGQPLPTLPVPVLRDELPGLGPLPATGRGLRAAAEAGVRLAFV 103
Cdd:PRK00576   1 MGRDKATLPLPGGTTTLVEHVVGIVGQRCAPVFVMAAPGQPLPELPAPVLRDELRGLGPLPATGRGLRAAAEAGARLAFV 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489507749 104 CAVDMPYLTVELIEDLARRAVQTDAEVVLPWDGRNHYLAAVYRTDLADRVDTLVGAGERKMSALVDASDALRIVMADSRP 183
Cdd:PRK00576  81 CAVDMPYLTVELIDDLARPAAQTDAEVVLPWDGRDHYLAAVYRTDLAERVDALVGAGERSMRALVDASDAQRIVMPESRP 160

                        170
                 ....*....|....*...
gi 489507749 184 LTNVNSAAGLHAPMQPGR 201
Cdd:PRK00576 161 LTNVNTAADLPAPMQPGR 178
MobA cd02503
MobA catalyzes the formation of molybdopterin guanine dinucleotide; The prokaryotic enzyme ...
 11-193 2.81e-49

MobA catalyzes the formation of molybdopterin guanine dinucleotide; The prokaryotic enzyme molybdopterin-guanine dinucleotide biosynthesis protein A (MobA). All mononuclear molybdoenzymes bind molybdenum in complex with an organic cofactor termed molybdopterin (MPT). In many bacteria, including Escherichia coli, molybdopterin can be further modified by attachment of a GMP group to the terminal phosphate of molybdopterin to form molybdopterin guanine dinucleotide (MGD). This GMP attachment step is catalyzed by MobA, by linking a guanosine 5'-phosphate to MPT forming molybdopterin guanine dinucleotide. This reaction requires GTP, MgCl2, and the MPT form of the cofactor. It is a reaction unique to prokaryotes, and therefore may represent a potential drug target.


Pssm-ID: 133000 [Multi-domain]  Cd Length: 181  Bit Score: 158.12  E-value: 2.81e-49
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489507749  11 LAGVVLAGGESRRMGRDKATLPLPGgtTTLVEHMVGILGQRCAPVFVMAAPGQ-PLPTLPVPVLRDELPGLGPLPATGRG 89
Cdd:cd02503    1 ITGVILAGGKSRRMGGDKALLELGG--KPLLEHVLERLKPLVDEVVISANRDQeRYALLGVPVIPDEPPGKGPLAGILAA 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489507749  90 LRAAAEAGVrlaFVCAVDMPYLTVELIEDLARRAVQTDAEVVLPWDGRNHYLAAVYRTDLADRVDTLVGAGERKMSALVD 169
Cdd:cd02503   79 LRAAPADWV---LVLACDMPFLPPELLERLLAAAEEGADAVVPKSGGRLQPLHALYHKSLLPALEELLEAGERRLRRLLE 155

                        170       180
                 ....*....|....*....|....*.
gi 489507749 170 ASD--ALRIVMADSRPLTNVNSAAGL 193
Cdd:cd02503  156 KLGvqYVEFEDERLDAFFNINTPEDL 181
MobA COG0746
Molybdopterin-guanine dinucleotide biosynthesis protein A [Coenzyme transport and metabolism]; ...
 8-189 1.47e-48

Molybdopterin-guanine dinucleotide biosynthesis protein A [Coenzyme transport and metabolism]; Molybdopterin-guanine dinucleotide biosynthesis protein A is part of the Pathway/BioSystem: Molybdopterin biosynthesis


Pssm-ID: 440509 [Multi-domain]  Cd Length: 188  Bit Score: 156.51  E-value: 1.47e-48
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489507749   8 TVPLAGVVLAGGESRRMGRDKATLPLPGgtTTLVEHMVGILGQRCAPVFVMAAPGQPLPTLPVPVLRDELPGLGPLPATG 87
Cdd:COG0746    2 TMPITGVILAGGRSRRMGQDKALLPLGG--RPLLERVLERLRPQVDEVVIVANRPERYAALGVPVVPDDPPGAGPLAGIL 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489507749  88 RGLRAAAEAGVrlaFVCAVDMPYLTVELIEDLArRAVQTDAEVVLPW-DGRNHYLAAVYRTDLADRVDTLVGAGERKMSA 166
Cdd:COG0746   80 AALEAAPAEWV---LVLACDMPFLPPDLVRRLL-EALEEGADAVVPRsGGRLEPLFALYRRSLLPALEAALAEGERSLRA 155

                        170       180
                 ....*....|....*....|....
gi 489507749 167 LVDASDALRIVMAD-SRPLTNVNS 189
Cdd:COG0746  156 LLERLDVVYVPFEDlDDAFFNVNT 179
NTP_transf_3 pfam12804
MobA-like NTP transferase domain; This family includes the MobA protein (Molybdopterin-guanine ...
 13-174 8.29e-29

MobA-like NTP transferase domain; This family includes the MobA protein (Molybdopterin-guanine dinucleotide biosynthesis protein A). The family also includes a wide range of other NTP transferase domain.


Pssm-ID: 463715 [Multi-domain]  Cd Length: 159  Bit Score: 104.97  E-value: 8.29e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489507749   13 GVVLAGGESRRMGRDKATLPLPGgtTTLVEHMVGILGQRCAPVFVMAAPGQ---PLPTLPVPVLRDELPGLGPLPATGRG 89
Cdd:pfam12804   1 AVILAGGRSSRMGGDKALLPLGG--KPLLERVLERLRPAGDEVVVVANDEEvlaALAGLGVPVVPDPDPGQGPLAGLLAA 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489507749   90 LRAAAEAGvrLAFVCAVDMPYLTVELIEDLARRAVQTDAEVVLPWDGRNHYLAAVYRTDLADRVDTLvgAGERKMSALVD 169
Cdd:pfam12804  79 LRAAPGAD--AVLVLACDMPFLTPELLRRLLAAAEESGADIVVPVYDGGRGHPLLYRRRLLPALEAL--LGDRGLRRLLR 154


                  ....*
gi 489507749  170 ASDAL 174
Cdd:pfam12804 155 RLDEV 159
molyb_mobA TIGR02665
molybdenum cofactor guanylyltransferase, proteobacterial; In many molybdopterin-containing ...
 11-189 3.91e-17

molybdenum cofactor guanylyltransferase, proteobacterial; In many molybdopterin-containing enzymes, including nitrate reductase and dimethylsulfoxide reductase, the cofactor is molybdopterin-guanine dinucleotide. The family described here contains MobA, molybdenum cofactor guanylyltransferase, from the Proteobacteria only. MobA can reconstitute molybdopterin-guanine dinucleotide biosynthesis without the product of the neighboring gene MobB. The probable MobA proteins of other lineages differ sufficiently that they are not included in scope of this family. [Biosynthesis of cofactors, prosthetic groups, and carriers, Molybdopterin]


Pssm-ID: 274249  Cd Length: 186  Bit Score: 75.40  E-value: 3.91e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489507749   11 LAGVVLAGGESRRM-GRDKATLPLPGGttTLVEHMVGILGQRCAPVFVMA----APGQPLpTLPVPVLRDELPG-LGPLP 84
Cdd:TIGR02665   1 ISGVILAGGRARRMgGRDKGLVELGGK--PLIEHVLARLRPQVSDLAISAnrnpERYAQA-GFGLPVVPDALADfPGPLA 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489507749   85 ATGRGLRAAAEAGVrlaFVCAVDMPYLTVELIEDLARRAVQTDAEVVLPWDG-RNHYLAAVYRTDLADRVDTLVGAGERK 163
Cdd:TIGR02665  78 GILAGLRWAGTDWV---LTVPCDTPFLPEDLVARLAAALEASDADIAVAHDGgRWHPVFALWPVALAPDLEAFLAAGERR 154

                         170       180
                  ....*....|....*....|....*..
gi 489507749  164 MSALVDASDALRIVMADS-RPLTNVNS 189
Cdd:TIGR02665 155 VRRFYARHGAVAVDFSDSpDAFANLNT 181
 
Name Accession Description Interval E-value
PRK00576 PRK00576
molybdopterin-guanine dinucleotide biosynthesis protein A; Provisional
 24-201 7.48e-101

molybdopterin-guanine dinucleotide biosynthesis protein A; Provisional


Pssm-ID: 234798  Cd Length: 178  Bit Score: 289.01  E-value: 7.48e-101
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489507749  24 MGRDKATLPLPGGTTTLVEHMVGILGQRCAPVFVMAAPGQPLPTLPVPVLRDELPGLGPLPATGRGLRAAAEAGVRLAFV 103
Cdd:PRK00576   1 MGRDKATLPLPGGTTTLVEHVVGIVGQRCAPVFVMAAPGQPLPELPAPVLRDELRGLGPLPATGRGLRAAAEAGARLAFV 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489507749 104 CAVDMPYLTVELIEDLARRAVQTDAEVVLPWDGRNHYLAAVYRTDLADRVDTLVGAGERKMSALVDASDALRIVMADSRP 183
Cdd:PRK00576  81 CAVDMPYLTVELIDDLARPAAQTDAEVVLPWDGRDHYLAAVYRTDLAERVDALVGAGERSMRALVDASDAQRIVMPESRP 160

                        170
                 ....*....|....*...
gi 489507749 184 LTNVNSAAGLHAPMQPGR 201
Cdd:PRK00576 161 LTNVNTAADLPAPMQPGR 178
MobA cd02503
MobA catalyzes the formation of molybdopterin guanine dinucleotide; The prokaryotic enzyme ...
 11-193 2.81e-49

MobA catalyzes the formation of molybdopterin guanine dinucleotide; The prokaryotic enzyme molybdopterin-guanine dinucleotide biosynthesis protein A (MobA). All mononuclear molybdoenzymes bind molybdenum in complex with an organic cofactor termed molybdopterin (MPT). In many bacteria, including Escherichia coli, molybdopterin can be further modified by attachment of a GMP group to the terminal phosphate of molybdopterin to form molybdopterin guanine dinucleotide (MGD). This GMP attachment step is catalyzed by MobA, by linking a guanosine 5'-phosphate to MPT forming molybdopterin guanine dinucleotide. This reaction requires GTP, MgCl2, and the MPT form of the cofactor. It is a reaction unique to prokaryotes, and therefore may represent a potential drug target.


Pssm-ID: 133000 [Multi-domain]  Cd Length: 181  Bit Score: 158.12  E-value: 2.81e-49
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489507749  11 LAGVVLAGGESRRMGRDKATLPLPGgtTTLVEHMVGILGQRCAPVFVMAAPGQ-PLPTLPVPVLRDELPGLGPLPATGRG 89
Cdd:cd02503    1 ITGVILAGGKSRRMGGDKALLELGG--KPLLEHVLERLKPLVDEVVISANRDQeRYALLGVPVIPDEPPGKGPLAGILAA 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489507749  90 LRAAAEAGVrlaFVCAVDMPYLTVELIEDLARRAVQTDAEVVLPWDGRNHYLAAVYRTDLADRVDTLVGAGERKMSALVD 169
Cdd:cd02503   79 LRAAPADWV---LVLACDMPFLPPELLERLLAAAEEGADAVVPKSGGRLQPLHALYHKSLLPALEELLEAGERRLRRLLE 155

                        170       180
                 ....*....|....*....|....*.
gi 489507749 170 ASD--ALRIVMADSRPLTNVNSAAGL 193
Cdd:cd02503  156 KLGvqYVEFEDERLDAFFNINTPEDL 181
MobA COG0746
Molybdopterin-guanine dinucleotide biosynthesis protein A [Coenzyme transport and metabolism]; ...
 8-189 1.47e-48

Molybdopterin-guanine dinucleotide biosynthesis protein A [Coenzyme transport and metabolism]; Molybdopterin-guanine dinucleotide biosynthesis protein A is part of the Pathway/BioSystem: Molybdopterin biosynthesis


Pssm-ID: 440509 [Multi-domain]  Cd Length: 188  Bit Score: 156.51  E-value: 1.47e-48
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489507749   8 TVPLAGVVLAGGESRRMGRDKATLPLPGgtTTLVEHMVGILGQRCAPVFVMAAPGQPLPTLPVPVLRDELPGLGPLPATG 87
Cdd:COG0746    2 TMPITGVILAGGRSRRMGQDKALLPLGG--RPLLERVLERLRPQVDEVVIVANRPERYAALGVPVVPDDPPGAGPLAGIL 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489507749  88 RGLRAAAEAGVrlaFVCAVDMPYLTVELIEDLArRAVQTDAEVVLPW-DGRNHYLAAVYRTDLADRVDTLVGAGERKMSA 166
Cdd:COG0746   80 AALEAAPAEWV---LVLACDMPFLPPDLVRRLL-EALEEGADAVVPRsGGRLEPLFALYRRSLLPALEAALAEGERSLRA 155

                        170       180
                 ....*....|....*....|....
gi 489507749 167 LVDASDALRIVMAD-SRPLTNVNS 189
Cdd:COG0746  156 LLERLDVVYVPFEDlDDAFFNVNT 179
NTP_transf_3 pfam12804
MobA-like NTP transferase domain; This family includes the MobA protein (Molybdopterin-guanine ...
 13-174 8.29e-29

MobA-like NTP transferase domain; This family includes the MobA protein (Molybdopterin-guanine dinucleotide biosynthesis protein A). The family also includes a wide range of other NTP transferase domain.


Pssm-ID: 463715 [Multi-domain]  Cd Length: 159  Bit Score: 104.97  E-value: 8.29e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489507749   13 GVVLAGGESRRMGRDKATLPLPGgtTTLVEHMVGILGQRCAPVFVMAAPGQ---PLPTLPVPVLRDELPGLGPLPATGRG 89
Cdd:pfam12804   1 AVILAGGRSSRMGGDKALLPLGG--KPLLERVLERLRPAGDEVVVVANDEEvlaALAGLGVPVVPDPDPGQGPLAGLLAA 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489507749   90 LRAAAEAGvrLAFVCAVDMPYLTVELIEDLARRAVQTDAEVVLPWDGRNHYLAAVYRTDLADRVDTLvgAGERKMSALVD 169
Cdd:pfam12804  79 LRAAPGAD--AVLVLACDMPFLTPELLRRLLAAAEESGADIVVPVYDGGRGHPLLYRRRLLPALEAL--LGDRGLRRLLR 154


                  ....*
gi 489507749  170 ASDAL 174
Cdd:pfam12804 155 RLDEV 159
mobA PRK00317
molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed
 10-198 2.25e-19

molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed


Pssm-ID: 234725 [Multi-domain]  Cd Length: 193  Bit Score: 81.39  E-value: 2.25e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489507749  10 PLAGVVLAGGESRRM-GRDKATLPLPGgtTTLVEHMVGILGQRCAPVFVMAAPGQ-PLPTLPVPVLRDELPGL-GPLPat 86
Cdd:PRK00317   3 PITGVILAGGRSRRMgGVDKGLQELNG--KPLIQHVIERLAPQVDEIVINANRNLaRYAAFGLPVIPDSLADFpGPLA-- 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489507749  87 grGLRAA-AEAGVRLAFVCAVDMPYLTVELIEDLARRAVQTDAEVVLPWDG-RNHYLAAVYRTDLADRVDTLVGAGERKM 164
Cdd:PRK00317  79 --GILAGlKQARTEWVLVVPCDTPFIPPDLVARLAQAAGKDDADVAWAHDGgRLHPTFALYSVALLPDLEAYLAAGERKV 156

                        170       180       190
                 ....*....|....*....|....*....|....*
gi 489507749 165 SALVDASDALRIVMADSR-PLTNVNSAAGLHAPMQ 198
Cdd:PRK00317 157 MAFYARHGGVAVDFSDPKdAFFNINTPEDLAQLEE 191
molyb_mobA TIGR02665
molybdenum cofactor guanylyltransferase, proteobacterial; In many molybdopterin-containing ...
 11-189 3.91e-17

molybdenum cofactor guanylyltransferase, proteobacterial; In many molybdopterin-containing enzymes, including nitrate reductase and dimethylsulfoxide reductase, the cofactor is molybdopterin-guanine dinucleotide. The family described here contains MobA, molybdenum cofactor guanylyltransferase, from the Proteobacteria only. MobA can reconstitute molybdopterin-guanine dinucleotide biosynthesis without the product of the neighboring gene MobB. The probable MobA proteins of other lineages differ sufficiently that they are not included in scope of this family. [Biosynthesis of cofactors, prosthetic groups, and carriers, Molybdopterin]


Pssm-ID: 274249  Cd Length: 186  Bit Score: 75.40  E-value: 3.91e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489507749   11 LAGVVLAGGESRRM-GRDKATLPLPGGttTLVEHMVGILGQRCAPVFVMA----APGQPLpTLPVPVLRDELPG-LGPLP 84
Cdd:TIGR02665   1 ISGVILAGGRARRMgGRDKGLVELGGK--PLIEHVLARLRPQVSDLAISAnrnpERYAQA-GFGLPVVPDALADfPGPLA 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489507749   85 ATGRGLRAAAEAGVrlaFVCAVDMPYLTVELIEDLARRAVQTDAEVVLPWDG-RNHYLAAVYRTDLADRVDTLVGAGERK 163
Cdd:TIGR02665  78 GILAGLRWAGTDWV---LTVPCDTPFLPEDLVARLAAALEASDADIAVAHDGgRWHPVFALWPVALAPDLEAFLAAGERR 154

                         170       180
                  ....*....|....*....|....*..
gi 489507749  164 MSALVDASDALRIVMADS-RPLTNVNS 189
Cdd:TIGR02665 155 VRRFYARHGAVAVDFSDSpDAFANLNT 181
MocA COG2068
CTP:molybdopterin cytidylyltransferase MocA [Coenzyme transport and metabolism];
10-137 3.32e-16

CTP:molybdopterin cytidylyltransferase MocA [Coenzyme transport and metabolism];


Pssm-ID: 441671 [Multi-domain]  Cd Length: 195  Bit Score: 73.27  E-value: 3.32e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489507749  10 PLAGVVLAGGESRRMGRDKATLPLPGgtTTLVEHMVGILGQ-RCAPVFVMAAPGQPLptlpvpvLRDELPGLG------P 82
Cdd:COG2068    3 KVAAIILAAGASSRMGRPKLLLPLGG--KPLLERAVEAALAaGLDPVVVVLGADAEE-------VAAALAGLGvrvvvnP 73

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 489507749  83 LPATGRG--LRAAAEA---GVRLAFVCAVDMPYLTVELIEDLARRAVQTDAEVVLP-WDGR 137
Cdd:COG2068   74 DWEEGMSssLRAGLAAlpaDADAVLVLLGDQPLVTAETLRRLLAAFRESPASIVAPtYDGR 134
PRK14489 PRK14489
putative bifunctional molybdopterin-guanine dinucleotide biosynthesis protein MobA/MobB; ...
 11-201 4.21e-15

putative bifunctional molybdopterin-guanine dinucleotide biosynthesis protein MobA/MobB; Provisional


Pssm-ID: 237727 [Multi-domain]  Cd Length: 366  Bit Score: 72.48  E-value: 4.21e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489507749  11 LAGVVLAGGESRRM-GRDKATLPLPGgtTTLVEHMVGILGQRCAPVFVMAA--PGQPLPTLP-VPVLRDELPGL-GPLPA 85
Cdd:PRK14489   6 IAGVILAGGLSRRMnGRDKALILLGG--KPLIERVVDRLRPQFARIHLNINrdPARYQDLFPgLPVYPDILPGFqGPLSG 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489507749  86 TGRGLraaAEAGVRLAFVCAVDMPYLTVELIEDLARRAVQTDAEVVLPWDG-RNHYLAAVYRTDLADRVDTLVGAGERKm 164
Cdd:PRK14489  84 ILAGL---EHADSEYLFVVACDTPFLPENLVKRLSKALAIEGADIAVPHDGeRAHPLFALYHRSCLPALRRYLAEGERR- 159

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....
gi 489507749 165 saLVDASDALRIVMAD----SRPLTNVNSAAGL---HAPMQPGR 201
Cdd:PRK14489 160 --LFDFFQRQRVRYVDlstqKDAFFNVNTPEDLeqlRAIPDGTT 201
GT_2_like_f cd04182
GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; ...
 11-133 7.48e-14

GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; GT-2 includes diverse families of glycosyltransferases with a common GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. These are enzymes that catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. Glycosyltransferases have been classified into more than 90 distinct sequence based families.


Pssm-ID: 133025 [Multi-domain]  Cd Length: 186  Bit Score: 66.81  E-value: 7.48e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489507749  11 LAGVVLAGGESRRMGRDKATLPLPGgtTTLVEHMVGILGQ-RCAPVFVMAAPGQPLptlpvpvLRDELPGLG------PL 83
Cdd:cd04182    1 IAAIILAAGRSSRMGGNKLLLPLDG--KPLLRHALDAALAaGLSRVIVVLGAEADA-------VRAALAGLPvvvvinPD 71

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 489507749  84 PATGRG--LRAAAEA---GVRLAFVCAVDMPYLTVELIEDLARRAVQTDAEVVLP 133
Cdd:cd04182   72 WEEGMSssLAAGLEAlpaDADAVLILLADQPLVTAETLRALIDAFREDGAGIVAP 126
PRK14500 PRK14500
putative bifunctional molybdopterin-guanine dinucleotide biosynthesis protein MoaC/MobA; ...
 10-119 8.11e-14

putative bifunctional molybdopterin-guanine dinucleotide biosynthesis protein MoaC/MobA; Provisional


Pssm-ID: 237734 [Multi-domain]  Cd Length: 346  Bit Score: 68.77  E-value: 8.11e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489507749  10 PLAGVVLAGGESRRMGRDKATLPLPGGTTTlvEHMVGILGQRCAPVFVMAAPGQ----PLPTLpvPVLRDELPGLGPLPA 85
Cdd:PRK14500 160 PLYGLVLTGGKSRRMGKDKALLNYQGQPHA--QYLYDLLAKYCEQVFLSARPSQwqgtPLENL--PTLPDRGESVGPISG 235

                         90       100       110
                 ....*....|....*....|....*....|....
gi 489507749  86 TGRGLRAAAEAGvrlAFVCAVDMPYLTVELIEDL 119
Cdd:PRK14500 236 ILTALQSYPGVN---WLVVACDLAYLNSETVEKL 266
PRK02726 PRK02726
molybdenum cofactor guanylyltransferase;
11-133 1.03e-12

molybdenum cofactor guanylyltransferase;


Pssm-ID: 235063  Cd Length: 200  Bit Score: 63.90  E-value: 1.03e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489507749  11 LAGVVLAGGESRRMGRDKATLPLPGgtTTLVEHMVGILGQRCAPVFVMaAPG----QPLPTLPVPVLRDELPGLGPLPAT 86
Cdd:PRK02726   8 LVALILAGGKSSRMGQDKALLPWQG--VPLLQRVARIAAACADEVYII-TPWperyQSLLPPGCHWLREPPPSQGPLVAF 84

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 489507749  87 GRGLRAAAEAGVRLafvCAVDMPYLTVELIEDLARR--AVQTDAEVVLP 133
Cdd:PRK02726  85 AQGLPQIKTEWVLL---LACDLPRLTVDVLQEWLQQleNVPEEAIAALP 130
PRK14490 PRK14490
putative bifunctional molybdopterin-guanine dinucleotide biosynthesis protein MobB/MobA; ...
 9-188 3.01e-12

putative bifunctional molybdopterin-guanine dinucleotide biosynthesis protein MobB/MobA; Provisional


Pssm-ID: 237728 [Multi-domain]  Cd Length: 369  Bit Score: 64.30  E-value: 3.01e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489507749   9 VPLAGVVLAGGESRRMGRDKATLPLPGgtTTLVEHMVGILGQRCAPVFV---------MAAPGQPLPTlpvpvlrDELPG 79
Cdd:PRK14490 173 VPLSGLVLAGGRSSRMGSDKALLSYHE--SNQLVHTAALLRPHCQEVFIscraeqaeqYRSFGIPLIT-------DSYLD 243

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489507749  80 LGPLPatgrGLRAAAEAGVRLAF-VCAVDMPYLTVELIEDLARRAVqtdaevvlPW----------DGRNHYLAAVYRTD 148
Cdd:PRK14490 244 IGPLG----GLLSAQRHHPDAAWlVVACDLPFLDEATLQQLVEGRN--------PFrfatafrhpdSGRPEPLCAIYEPK 311

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|
gi 489507749 149 LADRVDTLVGAGERKMSALVDASDALRIVMADSRPLTNVN 188
Cdd:PRK14490 312 SRLRLLLRHAAGNNSLRSFLATSRIEELEPTDPEALQNIN 351
PRK00560 PRK00560
molybdenum cofactor guanylyltransferase MobA;
14-188 2.01e-10

molybdenum cofactor guanylyltransferase MobA;


Pssm-ID: 167003  Cd Length: 196  Bit Score: 57.46  E-value: 2.01e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489507749  14 VVLAGGESRRMGRDKATLPLpGGTTTLVEHMVGILGQRCAPVFVMAAPGQplPTLPVPVLRDElpgLGPLPATGRGLRAA 93
Cdd:PRK00560  12 VILAGGKSSRMGENKALLPF-GSYSSLLEYQYTRLLKLFKKVYISTKDKK--FEFNAPFLLEK---ESDLFSPLFGIINA 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489507749  94 AEA-GVRLAFVCAVDMPYLTVELIEDLarRAVQTDAEVVLPWDGRNHYLAAVYRTDLADRVDTLVGAGERKMSALVDASD 172
Cdd:PRK00560  86 FLTlQTPEIFFISVDTPFVSFESIKKL--CGKENFSVTYAKSPTKEHYLISLWHQSLLNALIYALKTQNYRLSDLVKNTS 163

                        170
                 ....*....|....*.
gi 489507749 173 ALRIVMADSRPLTNVN 188
Cdd:PRK00560 164 SQAVHFEDEEEFLNLN 179
matur_MocA_YgfJ TIGR03310
molybdenum cofactor cytidylyltransferase; Members of this protein include MocA, which ...
 12-133 1.95e-08

molybdenum cofactor cytidylyltransferase; Members of this protein include MocA, which transfers cytosine from CTP to molybdopterin during molybdopterin cytosine dinucleotide (MCD) cofactor biosynthesis. It is distantly related to MobA, the GTP:molybdopterin guanylyltransferase. The MocA family is particularly closely related in phylogenetic distribution to other markers of selenium-dependent molybdenum hydroxylases (SDMH), suggesting most SDMH must use MCD rather than molybdopterin guanine dinucleotide.


Pssm-ID: 274516  Cd Length: 188  Bit Score: 51.96  E-value: 1.95e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489507749   12 AGVVLAGGESRRMGRDKATLPLPGGttTLVEHMV-GILGQRCAPVFVMAAP-GQPLPTLPVPVLRDELPgLGPLPATGRG 89
Cdd:TIGR03310   1 DAIILAAGLSSRMGQNKLLLPYKGK--TILEHVVdNALRLFFDEVILVLGHeADELVALLANHSNITLV-HNPQYAEGQS 77

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 489507749   90 --LRAAAEAGVRL--AFVCAVDMPYLTVELIEDLARRAVQTDAEVVLP 133
Cdd:TIGR03310  78 ssIKLGLELPVQSdgYLFLLGDQPFVTPDIIQLLLEAFALKNDEIVVP 125
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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