|
Name |
Accession |
Description |
Interval |
E-value |
| IleS |
COG0060 |
Isoleucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Isoleucyl-tRNA ... |
14-900 |
0e+00 |
|
Isoleucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Isoleucyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 439830 [Multi-domain] Cd Length: 931 Bit Score: 1206.83 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489502821 14 PDLPALELEVLDYWSRDDTFRASIARRDGAPEYVFYDGPPFANGLPHYGHLLTGYVKDIVPRYRTMRGYKVERRFGWDTH 93
Cdd:COG0060 16 ANLPKREPEILKFWEENDIYEKSREARAGRPKFVLHDGPPYANGDIHIGHALNKILKDIIVRYKTMRGFDVPYVPGWDCH 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489502821 94 GLPAELEVERQLGITdKSQIEAMGIAAFNDACRASVLRYTDEWQAYVTRQARWVDFDNDYKTLDLAYMESVIWAFKQLWD 173
Cdd:COG0060 96 GLPIELKVEKELGIK-KKDIEKVGIAEFREKCREYALKYVDEQREDFKRLGVWGDWDNPYLTMDPEYEESIWWALKKLYE 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489502821 174 KGLAYEGYRVLPYCWRDETPLSNHELrmdddVYQSRQDPAVTVGFKVVGGQPDNGLDGAYLLVWTTTPWTLPSNLAVAVS 253
Cdd:COG0060 175 KGLLYKGLKPVPWCPRCGTALAEAEV-----EYKDVTSPSIYVKFPVKDEKALLLLEDAYLVIWTTTPWTLPANLAVAVH 249
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489502821 254 PDITYVQVQA-GDRRFVLAEARLAAYARELG-EEPVVLGTYRGAELLGTRYLPPFAYFMDWPNAFQVLAGDFVTTDDGTG 331
Cdd:COG0060 250 PDIDYVLVEVtGGERLILAEALVEAVLKELGiEDYEVLATFKGAELEGLRYEHPFYYVVGYDRAHPVILGDYVTTEDGTG 329
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489502821 332 IVHMAPAYGEDDMVVAEAVGIAPVTPVDSKGRFDVTVADYQGQHVFDANAQIVRDLKtQSGpaavngpVLIRHETYEHPY 411
Cdd:COG0060 330 IVHTAPGHGEDDFEVGKKYGLPVLNPVDDDGRFTEEAPLFAGLFVKDANPAIIEDLK-ERG-------ALLAREKITHSY 401
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489502821 412 PHCWRCRNPLIYRSVSSWFVRVTDFRDRMVELNQQITWYPEHvKDGQFGKWLQGARDWSISRNRYWGTPIPVWKSDDPAY 491
Cdd:COG0060 402 PHCWRCKTPLIYRATPQWFISMDKLRDRALEAIEKVNWIPEW-GEGRFGNMLENRPDWCISRQRYWGVPIPIWVCEDCGE 480
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489502821 492 PRID--VYGSLDELERDFGVRP---ANLHRPYIDElTRPNPDDPtgrSTMRRIPDVLDVWFDSGSMPYAQVhypfENLDw 566
Cdd:COG0060 481 LHRTeeVIGSVAELLEEEGADAwfeLDLHRPFLDE-TLKCPKCG---GTMRRVPDVLDVWFDSGSMHFAVL----ENRE- 551
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489502821 567 fQGHYPGDFIVEYIGQTRGWFYTLHVLATALFDRPAFKTCVAHGIVLGFDGQKMSKSLRNYPDVTEVFDRDGSDAMRWFL 646
Cdd:COG0060 552 -ELHFPADFYLEGSDQTRGWFYSSLLTSTALFGRAPYKNVLTHGFVLDEDGRKMSKSLGNVVDPQEVIDKYGADILRLWV 630
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489502821 647 MASPilRGGNLIVTEQGIRDgVRQVLLPLWNTYSFLAL----YAPKVGTWRVDSVHVLDRYILAKLAVLRDDLSESMEVY 722
Cdd:COG0060 631 ASSD--YWGDLRFSDEILKE-VRDVYRRLRNTYRFLLAnlddFDPAEDAVPYEDLPELDRWILSRLNELIKEVTEAYDNY 707
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489502821 723 DIPGACEHLRQF-TEALTNWYVRRSRSRFWAEDADAID------TLHTVLEVTTRLAAPLLPLITEIIWRGLTRER--SV 793
Cdd:COG0060 708 DFHRAYRALHNFcVEDLSNWYLDISKDRLYTEAADSLDrraaqtTLYEVLETLVRLLAPILPFTAEEIWQNLPGEAeeSV 787
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489502821 794 HLTDWPAPDLLPSDADLVAAMDQVRDVCSAAS----SLRKAKklRVRLPLPKLIVAVENPQL---LRPFVDLIGDELNVK 866
Cdd:COG0060 788 HLADWPEVDEELIDEELEAKWDLVREVRSAVLkaleAARKEK--LIRQPLEAAVVLYADEELaaaLESLGDLLAEELNVS 865
|
890 900 910
....*....|....*....|....*....|....
gi 489502821 867 QVELTDAIDTYGRFELTvNARVAGPRLGKDVQAA 900
Cdd:COG0060 866 EVELVDDAEDLGKDALK-ALDVEGISVTVEVEKA 898
|
|
| PLN02882 |
PLN02882 |
aminoacyl-tRNA ligase |
15-991 |
0e+00 |
|
aminoacyl-tRNA ligase
Pssm-ID: 215477 [Multi-domain] Cd Length: 1159 Bit Score: 933.37 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489502821 15 DLPALELEVLDYWSRDDTFRASIARRDGAPEYVFYDGPPFANGLPHYGHLLTGYVKDIVPRYRTMRGYKVERRFGWDTHG 94
Cdd:PLN02882 9 SFPKQEEKILSLWSEIDAFKTQLKRTEGLPEYIFYDGPPFATGLPHYGHILAGTIKDIVTRYQSMTGHHVTRRFGWDCHG 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489502821 95 LPAELEVERQLGITDKSQIEAMGIAAFNDACRASVLRYTDEWQAYVTRQARWVDFDNDYKTLDLAYMESVIWAFKQLWDK 174
Cdd:PLN02882 89 LPVEYEIDKKLGIKRRDDVLKMGIDKYNEECRSIVTRYSKEWEKTVTRTGRWIDFENDYKTMDPKFMESVWWVFKQLFEK 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489502821 175 GLAYEGYRVLPYCWRDETPLSNHELRMDddvYQSRQDPAVTVGFKVVGGQpdnglDGAYLLVWTTTPWTLPSNLAVAVSP 254
Cdd:PLN02882 169 GLVYKGFKVMPYSTACKTPLSNFEAGLN---YKDVSDPAVMVSFPIVGDP-----DNASFVAWTTTPWTLPSNLALCVNP 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489502821 255 DITYVQV--QAGDRRFVLAEARLAAY------------ARELGEEPVVLGTYRGAELLGTRYLPPFAYFMDW-PNAFQVL 319
Cdd:PLN02882 241 NFTYVKVrnKYTGKVYIVAESRLSALptakpkskkgskPENAAEGYEVLAKVPGSSLVGKKYEPLFDYFSEFsDTAFRVV 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489502821 320 AGDFVTTDDGTGIVHMAPAYGEDDMVVAEAVGI-----APVTPVDSKGRFDVTVADYQGQHVFDANAQIVRDLKTQSGpa 394
Cdd:PLN02882 321 ADDYVTDDSGTGVVHCAPAFGEDDYRVCLANGIiekggNLPVPVDDDGCFTEKVTDFSGRYVKDADKDIIAAIKAKGR-- 398
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489502821 395 avngpvLIRHETYEHPYPHCWRCRNPLIYRSVSSWFVRVTDFRDRMVELNQQITWYPEHVKDGQFGKWLQGARDWSISRN 474
Cdd:PLN02882 399 ------LVKSGSITHSYPFCWRSDTPLIYRAVPSWFVKVEEIKDRLLENNKQTYWVPDYVKEKRFHNWLENARDWAVSRS 472
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489502821 475 RYWGTPIPVWKSDDPAypRIDVYGSLDELERDFGVRPANLHRPYIDELTRPNPDDPtGRSTMRRIPDVLDVWFDSGSMPY 554
Cdd:PLN02882 473 RFWGTPLPIWISDDGE--EVVVIGSIAELEKLSGVKVTDLHRHFIDHITIPSSRGP-EFGVLRRVDDVFDCWFESGSMPY 549
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489502821 555 AQVHYPFENLDWFQGHYPGDFIVEYIGQTRGWFYTLHVLATALFDRPAFKTCVAHGIVLGFDGQKMSKSLRNYPDVTEVF 634
Cdd:PLN02882 550 AYIHYPFENKELFEKNFPADFVAEGLDQTRGWFYTLMVLSTALFDKPAFKNLICNGLVLAEDGKKMSKSLKNYPDPNEVI 629
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489502821 635 DRDGSDAMRWFLMASPILRGGNLIVTEQGIRDGVRQVLLPLWNTYSFL------------ALYAPKVGTWRVDSVHVLDR 702
Cdd:PLN02882 630 DKYGADALRLYLINSPVVRAEPLRFKEEGVFGVVKDVFLPWYNAYRFLvqnakrleveggAPFVPLDLAKLQNSANVLDR 709
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489502821 703 YILAKLAVLRDDLSESMEVYDIPGACEHLRQFTEALTNWYVRRSRSRFWAEDAD-----AIDTLHTVLEVTTRLAAPLLP 777
Cdd:PLN02882 710 WINSATQSLVKFVREEMGAYRLYTVVPYLVKFIDNLTNIYVRFNRKRLKGRTGEedcrtALSTLYNVLLTSCKVMAPFTP 789
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489502821 778 LITEIIWRGLTR-----ERSVHLTDWPAPDLLPSDADLVAAMDQVRDVCSAASSLRKAKKLRVRLPLPKLIVAVENPQLL 852
Cdd:PLN02882 790 FFTEVLYQNLRKvlpgsEESIHYCSFPQVDEGELDERIEQSVSRMQTVIELARNIRERHNKPLKTPLKEMVVVHPDAEFL 869
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489502821 853 R----PFVDLIGDELNVKQVELTDAIDTYGRFELTVNARVAGPRLGKDVQAAIKAVKA----------GDGVINPDGTLL 918
Cdd:PLN02882 870 DditgKLKEYVLEELNVRSLVPCNDPLKYASLRAEPNFSVLGKRLGKSMGLVAKEVKAmsqddilefeKAGEVTIAGHTL 949
|
970 980 990 1000 1010 1020 1030
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 489502821 919 AGPAVLTPDEYNSRlVAADPESTAALPDGAGLVVLDGTVTAELEAEGWAKDRIRELQELRKSTGLDVSDRIRV 991
Cdd:PLN02882 950 KAGDIKVVRDFKRP-EGVSKEDIDAAGDGDVLVILDLRVDESLLEAGVAREVVNRIQKLRKKAGLEPTDKVEV 1021
|
|
| ileS |
TIGR00392 |
isoleucyl-tRNA synthetase; The isoleucyl tRNA synthetase (IleS) is a class I amino acyl-tRNA ... |
14-853 |
0e+00 |
|
isoleucyl-tRNA synthetase; The isoleucyl tRNA synthetase (IleS) is a class I amino acyl-tRNA ligase and is particularly closely related to the valyl tRNA synthetase. This model may recognize IleS from every species, including eukaryotic cytosolic and mitochondrial forms. [Protein synthesis, tRNA aminoacylation]
Pssm-ID: 273054 [Multi-domain] Cd Length: 861 Bit Score: 848.20 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489502821 14 PDLPALELEVLDYWSRDDTFRASIARRDGAPEYVFYDGPPFANGLPHYGHLLTGYVKDIVPRYRTMRGYKVERRFGWDTH 93
Cdd:TIGR00392 6 GNLSKREEKILAFWQENDIFEKVKKLNKGKPEFIFHDGPPYANGSIHLGHALNKILKDIILRYKTMQGFNVTRKPGWDTH 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489502821 94 GLPAELEVERQLGITDKSQIEAMGIAAFNDACRASVLRYTDEWQAYVTRQARWVDFDNDYKTLDLAYMESVIWAFKQLWD 173
Cdd:TIGR00392 86 GLPIEHKVEKKLGISGKKEISSLEIEEFREKCREFALKQIEEQREQFQRLGVWGDWENPYKTMDPSYEESQWWLFKEAHE 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489502821 174 KGLAYEGYRVLPYCWRDETPLSNHELRMDDDvYQSRQDPAVTVGFKVVGG-QPDNGLDGAYLLVWTTTPWTLPSNLAVAV 252
Cdd:TIGR00392 166 KGLLYRGLKPVYWSPRCRTALAEAEVEYKEN-YKDVKDPSIYVKFPVKKDkKTYLKVKLSSLLIWTTTPWTLPSNLAIAV 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489502821 253 SPDITYVQVQAGDRR--FVLAEARLAAYARELGEEPVVLGTYRGAELLGTRYLPPFAYF--MDWPNAFQVLAGDFVTTDD 328
Cdd:TIGR00392 245 HPDFEYALVQDNTKVeyFILAKKLVEKLYNKAGSDYEIIKTFKGSDLEGLEYEHPLYDFvsQLKEGAPVVIGGDHVTTED 324
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489502821 329 GTGIVHMAPAYGEDDMVVAEAVGIAPVTPVDSKGRFDVTVADYQGQHV-------FDANAQIVRDLKTQSgpaavngpVL 401
Cdd:TIGR00392 325 GTGIVHTAPGHGEEDYEIGKKYGLEVLSPVDEKGVYTEGVNDFQGRFVkdadkdiIKANKIIIEQLKDKG--------LL 396
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489502821 402 IRHETYEHPYPHCWRCRNPLIYRSVSSWFVRVTDFRDRMVELNQQITWYPEHVKdGQFGKWLQGARDWSISRNRYWGTPI 481
Cdd:TIGR00392 397 LKAEKITHSYPHCWRTKTPVIYRATEQWFIKTKDIKDQMLEQIKKVNWVPEWGE-GRFGNWLENRPDWCISRQRYWGIPI 475
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489502821 482 PVWKSDDPAYPRidVYGSLDELERDFGVRPAN-----LHRPYIDELTRPNPDDptgrSTMRRIPDVLDVWFDSGSMPYAQ 556
Cdd:TIGR00392 476 PIWYCEDTGEPI--VVGSIEELIELIELKGIDawfedLHRDFLDKITLKSGDG----GEYRRVPDVLDVWFDSGSMPYAS 549
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489502821 557 VHYPFENLDwFQGHYPGDFIVEYIGQTRGWFYTLHVLATALFDRPAFKTCVAHGIVLGFDGQKMSKSLRNYPDVTEVFDR 636
Cdd:TIGR00392 550 IHYPFENEK-FKEVFPADFILEGSDQTRGWFYSSLAIGTALFGQAPYKNVITHGFTLDEKGRKMSKSLGNVVDPLKVINK 628
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489502821 637 DGSDAMRWFL-MASPilrGGNLIVTEQGIRDGVRQVLLPLWNTYSFLALYA------PKVGTWRVDSVHVLDRYILAKLA 709
Cdd:TIGR00392 629 YGADILRLYVaSSDP---WEDLRFSDEILKQVVEKYRKIRWNTYRFLLTYAnldkfdPLFNSVAVEKFPEEDRWILSRLN 705
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489502821 710 VLRDDLSESMEVYDIPGACEHLRQF-TEALTNWYVRRSRSRFWAEDAD-----AIDTLHTVLEVTTRLAAPLLPLITEII 783
Cdd:TIGR00392 706 SLVEEVNEALEKYNFHKVLRALQDFiVEELSNWYIRIIRDRLYCEAKDndkraAQTTLYYALLTLVRLLAPFLPHTAEEI 785
|
810 820 830 840 850 860 870
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 489502821 784 WRGLTR---ERSVHLTDWPAPDLLPSDADLVAAMDQVRDVCSAASSLRKAKKLRVRLPLPKLIVAVENPQLLR 853
Cdd:TIGR00392 786 YQNLPGgeeEESVHLNLWPEVDEEFIDEALEANMAIVREIVEAFLALRDAANKKLRQPLKELVIGKSLEAVLK 858
|
|
| PTZ00427 |
PTZ00427 |
isoleucine-tRNA ligase, putative; Provisional |
14-984 |
0e+00 |
|
isoleucine-tRNA ligase, putative; Provisional
Pssm-ID: 173617 [Multi-domain] Cd Length: 1205 Bit Score: 703.65 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489502821 14 PDLPALELEVLDYWSRDDTFRASIARRDGAPEYVFYDGPPFANGLPHYGHLLTGYVKDIVPRYRTMRGYKVERRFGWDTH 93
Cdd:PTZ00427 72 PNIVEEEEKVLKYWKSIDAFNTSNKLAKNKKAYIFYDGPPFATGLPHYGHLLAGIIKDCVTRYFYQCGFSVERKFGWDCH 151
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489502821 94 GLPAELEVERQLGITDKSQIEAMGIAAFNDACRASVLRYTDEWQAYVTRQARWVDFDNDYKTLDLAYMESVIWAFKQLWD 173
Cdd:PTZ00427 152 GLPIEYEIEKENNINKKEDILKMGIDVYNEKCRGIVLKYSNEWVKTVERIGRWIDFKNDYKTMDKTFMESVWWVFSELYK 231
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489502821 174 KGLAYEGYRVLPYCWRDETPLSNHELRMDddvYQSRQDPAVTVGFKVVGGQP---------------------------D 226
Cdd:PTZ00427 232 NNYVYKSFKVMPYSCKCNTPISNFELNLN---YKDTPDPSIIISFVLCSDFPkveeecnieedkqllgekysvlynnkrE 308
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489502821 227 NGLDGAY-------------LLVWTTTPWTLPSNLAVAVSPDITYVQVQ--AGDRRFVLAEARLAAYARELG---EEPVV 288
Cdd:PTZ00427 309 NSNNGNNnstnnvcyaqhseILAWTTTPWTLPSNLALCVNEHFTYLRIHhvKSNRVVIVGECRLEWIMKELKwnvEDLKI 388
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489502821 289 LGTYRGAELLGTRYLPPFAYFMDWPN----AFQVLAGDFVTTDDGTGIVHMAPAYGEDDMVVAEAVG-IAP-----VTPV 358
Cdd:PTZ00427 389 VNRFKGKELKGLRYKPLFTNFYEKYNfkerAYKILADDFVTDDAGTGIVHCAPTYGEDDFRVCKKNGvIDPeknifIDPL 468
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489502821 359 DSKGRFDVTVADYQGQHVFDANAQIVRDLKtqsgpaavNGPVLIRHETYEHPYPHCWRCRNPLIYRSVSSWFVRVTDFRD 438
Cdd:PTZ00427 469 DANGYFTNEVEEVQNLYIKEADNVIKKKLK--------NENRLLSNNTIVHSYPFCWRSDTPLIYRAIPAWFIRVSNSTN 540
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489502821 439 RMVELNQQITWYPEHVKDGQFGKWLQGARDWSISRNRYWGTPIPVWKsdDPAYPRIDVYGSLDELERDFGVRPAN-LHRP 517
Cdd:PTZ00427 541 ELVKNNETTYWIPAHIKEKKFHNWIKDAKDWCISRNRYWGTPIPIWA--DEKMETVICVESIKHLEELSGVKNINdLHRH 618
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489502821 518 YIDELTRPNPDDPTgRSTMRRIPDVLDVWFDSGSMPYAQVHYPF--ENLDwFQGHYPGDFIVEYIGQTRGWFYTLHVLAT 595
Cdd:PTZ00427 619 FIDHIEIKNPKGKT-YPKLKRIPEVFDCWFESGSMPYAKVHYPFstEKED-FHKIFPADFIAEGLDQTRGWFYTLLVIST 696
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489502821 596 ALFDRPAFKTCVAHGIVLGFDGQKMSKSLRNYPDVTEVFDRDGSDAMRWFLMASPILRGGNLIVTEQGIRDGVRQVLLPL 675
Cdd:PTZ00427 697 LLFDKAPFKNLICNGLVLASDGKKMSKRLKNYPDPLYILDKYGADSLRLYLINSVAVRAENLKFQEKGVNEVVKSFILPF 776
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489502821 676 WNTYSFLALYAPKVGT-----------WRVDSVHVLDRYILAKLAVLRDDLSESMEVYDIPGACEHLRQFTEALTNWYVR 744
Cdd:PTZ00427 777 YHSFRFFSQEVTRYEClnkkqflfntdYIYKNDNIMDQWIFSSVQSLTKSVHTEMKAYKLYNVLPKLLQFIENLTNWYIR 856
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489502821 745 RSRSRFWA----EDA-DAIDTLHTVLEVTTRLAAPLLPLITEIIWRGLTR--------------------------ERSV 793
Cdd:PTZ00427 857 LNRDRMRGslgeENClQSLCTTYRTLHLFTVLMAPFTPFITEYIYQQLRRvkstnehnennetgntkegdlnrgviHKSV 936
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489502821 794 HLTDWPAPDLLPS-DADLVAAMDQVRDVCSAASSLRKAKKLRVRLPLPKLIVAVENPQLLRPF---VDLIGDELNVKQVE 869
Cdd:PTZ00427 937 HFIMLPQVDEKYIiDYEIIELIEKMKDVILLGRVLRERRKVASKKPLKSITILHPNESYFKNFdqiSNYIKEELNVLNVE 1016
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489502821 870 LTDAIDTYGrFELTVNARVAGPRLG---KDVQAAIKAVKAGD-------GVINPDGTLLAGPAVLTPDEYNSRlvaadPE 939
Cdd:PTZ00427 1017 CSNDTSCLD-FSAIPNYKTLGVKLGynlKKVQNKIKNMDSESiklyqqeGKITLDNVTLEGDDIIIQMKPNFQ-----ND 1090
|
1050 1060 1070 1080
....*....|....*....|....*....|....*....|....*
gi 489502821 940 STAALPDGAGLVVLDGTVTAELEAEGWAKDRIRELQELRKSTGLD 984
Cdd:PTZ00427 1091 NTDIISNNYVTILMDFTTDQQLENMASARELCNHIQKMRKNLSLN 1135
|
|
| tRNA-synt_1 |
pfam00133 |
tRNA synthetases class I (I, L, M and V); Other tRNA synthetase sub-families are too ... |
23-657 |
0e+00 |
|
tRNA synthetases class I (I, L, M and V); Other tRNA synthetase sub-families are too dissimilar to be included.
Pssm-ID: 459685 [Multi-domain] Cd Length: 602 Bit Score: 633.68 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489502821 23 VLDYWSRDDTFRASIARRDGAPEYVFYDGPPFANGLPHYGHLLTGYVKDIVPRYRTMRGYKVERRFGWDTHGLPAELEVE 102
Cdd:pfam00133 2 IYEFWDEQGYFKPELEKRKGKPSFTIHDGPPNATGSLHIGHALAKTLKDIVIRYKRMKGYYVLWVPGWDHHGLPTEQVVE 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489502821 103 RQLGITDKSQIEAMGIAAFNDACRASVLRYTDEWQAYVTRQARWVDFDNDYKTLDLAYMESVIWAFKQLWDKGLAYEGYR 182
Cdd:pfam00133 82 KKLGIKEKKTRHKYGREEFREKCREWKMEYADEIRKQFRRLGRSIDWDREYFTMDPELEAAVWEVFVRLHDKGLIYRGKK 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489502821 183 VLPYCWRDETPLSNHELRmdddvYQSRQDPAVTVGFKVVGGqpdnglDGAYLLVWTTTPWTLPSNLAVAVSPDITYVqvq 262
Cdd:pfam00133 162 LVNWSPALNTALSNLEVE-----YKDVKGPSIHVAFPLADD------EGASLVIWTTTPWTLPGNTAVAVNPEFDYV--- 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489502821 263 AGDRRFVLAEARLAAYArELGEEPVVLGTYRGAELLGTRYLPPFAyfmdwPNAFQVLAGDFVTTDDGTGIVHMAPAYGED 342
Cdd:pfam00133 228 ITGEGYILAEALLKSLY-KKGTDKKILEDFRGKELEGKEAIHPFV-----NREIPIITDDYVDMEFGTGAVHIAPAHGEN 301
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489502821 343 DMVVAEAVGIAPVTPVDSKGRFDVTVADYQGQHVFDANAQIVRDLKTQSgpaavngpVLIRHETYEHPYPHCWRCRNPLI 422
Cdd:pfam00133 302 DYEVGQRHNLEVINPVDDDGTFTEEAPDFQGVYRFDARKKIVELLTEKG--------LLLKIEPFTHSYPFCWRSGTPII 373
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489502821 423 YRSVSSWFVRVTDFRDRMVELNQQITWYPEHvKDGQFGKWLQGARDWSISRNRYWGTPIPVWKSDDpaYPRIDVYGSLDE 502
Cdd:pfam00133 374 PRATPQWFVRMDELADQALEAVEKVQFVPKS-GEKRYFNWLANIQDWCISRQRWWGHPIPAWVSKD--TEEVVCRGELFE 450
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489502821 503 LERDF---GVRPANLHRPYIDELTRPNpddptgrSTMRRIPDVLDVWFDSGSMPYAQVHYPFENLDWFQGHYPGDFIVEY 579
Cdd:pfam00133 451 LVAGRfeeEGSIKWLHREAKDKLGYGK-------GTLEQDEDVLDTWFSSGSWPFSTLGWPFVNTEEFKKFFPADMLLEG 523
|
570 580 590 600 610 620 630
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 489502821 580 IGQTRGWFYTLHVLATALFDRPAFKTCVAHGIVLGFDGQKMSKSLRNYPDVTEVFDRDGSDAMRWFLMASPILRGGNL 657
Cdd:pfam00133 524 SDQTRGWFYRMIMLSTALTGSVPFKNVLVHGLVRDEQGRKMSKSLGNVIDPLDVIDKYGADALRLWLANSDYGRDINL 601
|
|
| PLN02843 |
PLN02843 |
isoleucyl-tRNA synthetase |
20-819 |
9.96e-109 |
|
isoleucyl-tRNA synthetase
Pssm-ID: 215452 [Multi-domain] Cd Length: 974 Bit Score: 361.40 E-value: 9.96e-109
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489502821 20 ELEVLDYWSRDDTFRASIARRDGAPeYVFYDGPPFANGLPHYGHLLTGYVKDIVPRYRTMRGYKVERRFGWDTHGLPAEL 99
Cdd:PLN02843 9 EPEIQKLWEENQVYKRVSDRNNGES-FTLHDGPPYANGDLHIGHALNKILKDFINRYQLLQGKKVHYVPGWDCHGLPIEL 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489502821 100 EVERQLgitDKSQIEAMGIAAFNDACRASVLRYTDEWQAYVTRQARWVDFDNDYKTLDLAYMESVIWAFKQLWDKGLAYE 179
Cdd:PLN02843 88 KVLQSL---DQEARKELTPIKLRAKAAKFAKKTVDTQRESFKRYGVWGDWENPYLTLDPEYEAAQIEVFGQMFLNGYIYR 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489502821 180 GYRvlPYCW--RDETPLSNHELRM-DDDVYQSrqdpaVTVGFKVVGGQPDNG------LDGAYLLVWTTTPWTLPSNLAV 250
Cdd:PLN02843 165 GRK--PVHWspSSRTALAEAELEYpEGHVSKS-----IYVAFPVVSPSETSPeeleefLPGLSLAIWTTTPWTMPANAAV 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489502821 251 AVSPDITY--VQVQA-----------------------GDRRFVLAEARLAAYARELGEEPVVLGTYRGAELLGTRYLPP 305
Cdd:PLN02843 238 AVNDKLQYsvVEVQSfsedestsggnkkkrpgnvlkeqQKLFLIVATDLVPALEAKWGVKLVVLKTFPGSDLEGCRYIHP 317
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489502821 306 FaYFMDWPnafQVLAGDFVTTDDGTGIVHMAPAYGEDDMVVAEAVGIAPVTPVDSKGRFDVTVADYQGQHVF-DANAQIV 384
Cdd:PLN02843 318 L-YNRESP---VVIGGDYITTESGTGLVHTAPGHGQEDYITGLKYGLPLLSPVDDAGKFTEEAGQFSGLSVLgEGNAAVV 393
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489502821 385 RDLKTQSgpaavngpVLIRHETYEHPYPHCWRCRNPLIYRSVSSWFVRVTDFRDRMVELNQQITWYPEHVKDgQFGKWLQ 464
Cdd:PLN02843 394 EALDEAG--------SLLMEEAYGHKYPYDWRTKKPTIFRATEQWFASVEGFRQAALDAIDKVKWIPAQGEN-RIRAMVS 464
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489502821 465 GARDWSISRNRYWGTPIPVW---KSDDP--------------AYPRIDVYGSLDELErdfgVRPANlHRPYIDELTRpnp 527
Cdd:PLN02843 465 GRSDWCISRQRTWGVPIPVFyhvETKEPlmneetiahvksivAQKGSDAWWYMDVED----LLPEK-YRDKASDYEK--- 536
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489502821 528 ddptGRSTMrripdvlDVWFDSGSmPYAQVHYPFENLDwfqghYPGDFIVEYIGQTRGWFYTLHVLATALFDRPAFKTCV 607
Cdd:PLN02843 537 ----GTDTM-------DVWFDSGS-SWAGVLGSREGLS-----YPADLYLEGSDQHRGWFQSSLLTSVATKGKAPYKSVL 599
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489502821 608 AHGIVLGFDGQKMSKSLRNYPDVTEVFD--RD-------GSDAMRwfLMASPILRGGNLIVTEQGIR---DGVRQvllpL 675
Cdd:PLN02843 600 THGFVLDEKGFKMSKSLGNVVDPRLVIEggKNqkqepayGADVLR--LWVASVDYTGDVLIGPQILKqmsDIYRK----L 673
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489502821 676 WNTYSFL----ALYAPKVGTwRVDSVHVLDRYILAKLAVLRDDLSESMEVYDIPGACEHLRQFTEA-LTNWYVRRSRSRF 750
Cdd:PLN02843 674 RGTLRYLlgnlHDWKPDNAV-PYEDLPSIDKYALFQLENVVNEIEESYDNYQFFKIFQILQRFTIVdLSNFYLDVAKDRL 752
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489502821 751 WAEDADAID------TLHTVLEVTTRLAAPLLPLITEIIWRGLTRER------SVHLTDWPAPD-----LLPSDADLVAA 813
Cdd:PLN02843 753 YVGGTTSFTrrscqtVLAAHLLSLLRAIAPILPHLAEDAWQNLPFQEdgsaaeSVFEAGWPTPNeewlsFPAEDVDFWSL 832
|
....*.
gi 489502821 814 MDQVRD 819
Cdd:PLN02843 833 LLEVRD 838
|
|
| valS |
PRK13208 |
valyl-tRNA synthetase; Reviewed |
14-873 |
1.56e-105 |
|
valyl-tRNA synthetase; Reviewed
Pssm-ID: 237306 [Multi-domain] Cd Length: 800 Bit Score: 348.34 E-value: 1.56e-105
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489502821 14 PDLPALELEVLDYWSRDDTFRASIARRDgaPEYVFYDGPPFANGLPHYGHLLtGYVK-DIVPRYRTMRGYKVERRFGWDT 92
Cdd:PRK13208 10 YDPEELEEKWQKIWEEEGTYKFDPDERK--PVYSIDTPPPTVSGSLHIGHVF-SYTHtDFIARYQRMRGYNVFFPQGWDD 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489502821 93 HGLPAELEVERQLGITdKSQIEAmgiAAFNDACRASVLRYTDEWQAYVTRQARWVDFDNDYKTLDLAYMESVIWAFKQLW 172
Cdd:PRK13208 87 NGLPTERKVEKYYGIR-KDDISR---EEFIELCRELTDEDEKKFRELWRRLGLSVDWSLEYQTISPEYRRISQKSFLDLY 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489502821 173 DKGLAYEGYRVLPYCWRDETPLSNHELRmdddvYQSRQDPAVTVGFKVVggqpdnglDGAYLLVWTTTPWTLPSNLAVAV 252
Cdd:PRK13208 163 KKGLIYRAEAPVLWCPRCETAIAQAEVE-----YREREGKLNYIKFPVE--------DGEEIEIATTRPELLPACVAVVV 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489502821 253 SPDityvqvqagDRRfvlaearlaaYARELGEEPVVlgtyrgaellgtrylPPFAYFMdwpnafQVLAGDFVTTDDGTGI 332
Cdd:PRK13208 230 HPD---------DER----------YKHLVGKTAIV---------------PLFGVEV------PILADPLVDPDFGTGA 269
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489502821 333 VhMAPAYG-EDDMVVAEAVGIAPVTPVDSKGRFDVTVADYQGQHVFDANAQIVRDLKTQSgpaavngpVLIRHETYEHPY 411
Cdd:PRK13208 270 V-MICTFGdKTDVTWWRELNLPTRIIIDEDGRMTEAAGKLAGLTIEEARKKIVEDLKSGG--------LLGKQEPIKHNV 340
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489502821 412 PHCWRCRNPLIYRSVSSWFVRVTDFRDRMVELNQQITWYPEHVKDgQFGKWLQG-ARDWSISRNRYWGTPIPVWKSDDPA 490
Cdd:PRK13208 341 KFCERCDTPLEILVTRQWFIKVLDLKEELLERGKEINWYPEHMRV-RLENWIEGlNWDWCISRQRYFGTPIPVWYCKDCG 419
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489502821 491 YPridVYGSLDELerdfgvrpanlhrPYideltRPNPDDPTGRSTMRRI-------PDVLDVWFDSGSMPYAQVHYPfEN 563
Cdd:PRK13208 420 HP---ILPDEEDL-------------PV-----DPTKDEPPGYKCPQCGspgfegeTDVMDTWATSSITPLIVTGWE-RD 477
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489502821 564 LDWF----------QGHypgDFIveyigqtRGW-FYTLhVLATALFDRPAFKTCVAHGIVLGFDGQKMSKSLRNYPDVTE 632
Cdd:PRK13208 478 EDLFekvfpmdlrpQGH---DII-------RTWlFYTI-LRAYLLTGKLPWKNIMISGMVLDPDGKKMSKSKGNVVTPEE 546
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489502821 633 VFDRDGSDAMR-WFLMASPilrGGNLIVTEQGIRDGvRQVLLPLWNTYSFLALYAPKVGTWRVDSVHVLDRYILAKLAVL 711
Cdd:PRK13208 547 LLEKYGADAVRyWAASARL---GSDTPFDEKQVKIG-RRLLTKLWNASRFVLHFSADPEPDKAEVLEPLDRWILAKLAKV 622
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489502821 712 RDDLSESMEVYDIPGACEHLRQFT-EALTNWYVRRSRSRFWAEDAD-----AIDTLHTVLEVTTRLAAPLLPLITEIIWR 785
Cdd:PRK13208 623 VEKATEALENYDFAKALEEIESFFwHVFCDDYLELVKSRAYGEDEEeeqksARYTLYTVLDTLLRLLAPFLPFITEEVWS 702
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489502821 786 GLtRERSVHLTDWPAPDLLPSDADLVAAMDQVRDVcsaASSLRKAK---KLRVRLPLPKLIVAVEN-PQLLRPFVDLIGD 861
Cdd:PRK13208 703 WL-YGGSVHRASWPEPDEELIDEEDEELGELAKEI---LSAVRKYKseaGLSLNAPLKKVEVYGPAdLELLEAAEEDLKA 778
|
890
....*....|..
gi 489502821 862 ELNVKQVELTDA 873
Cdd:PRK13208 779 AGNIEELELVEG 790
|
|
| valS |
TIGR00422 |
valyl-tRNA synthetase; The valyl-tRNA synthetase (ValS) is a class I amino acyl-tRNA ligase ... |
18-905 |
1.39e-101 |
|
valyl-tRNA synthetase; The valyl-tRNA synthetase (ValS) is a class I amino acyl-tRNA ligase and is particularly closely related to the isoleucyl tRNA synthetase. [Protein synthesis, tRNA aminoacylation]
Pssm-ID: 273070 [Multi-domain] Cd Length: 861 Bit Score: 339.34 E-value: 1.39e-101
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489502821 18 ALELEVLDYWSRDDTFRASIARRdgAPEYVFYDGPPFANGLPHYGHLLTGYVKDIVPRYRTMRGYKVERRFGWDTHGLPA 97
Cdd:TIGR00422 9 EVEKKWYKKWEKSGFFKPDGNSN--KPPFCIDIPPPNVTGSLHIGHALNWSIQDIIARYKRMKGYNVLWLPGTDHAGIAT 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489502821 98 ELEVERQLGITDKSQieamgiaafNDACRASVLRYTDEWQAY----VTRQAR----WVDFDNDYKTLDLAYMESVIWAFK 169
Cdd:TIGR00422 87 QVKVEKKLGAEGKTK---------HDLGREEFREKIWEWKEEsggtIKNQIKrlgaSLDWSRERFTMDEGLSKAVKEAFV 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489502821 170 QLWDKGLAYEGYRVLPYCWRDETPLSNHELrmdddVYQSRQDPAVTVGFKVVGGQPDngldgaYLLVWTTTPWTLPSNLA 249
Cdd:TIGR00422 158 RLYEKGLIYRGEYLVNWDPKLNTAISDIEV-----EYKEVKGKLYYIRYPLANGSKD------YLVVATTRPETMFGDTA 226
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489502821 250 VAVSPDityvqvqagDRRFvlaearlaayarelgeepvvlgtyrgAELLGTRYLPPFAyfmdwPNAFQVLAGDFVTTDDG 329
Cdd:TIGR00422 227 VAVHPE---------DERY--------------------------KHLIGKKVILPLT-----GRKIPIIADEYVDMEFG 266
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489502821 330 TGIVHMAPAYGEDDMVVAEAVGIAPVTPVDSKGRFDVTVADYQGQHVFDANAQIVRDLKTQSgpaavngpVLIRHETYEH 409
Cdd:TIGR00422 267 TGAVKVTPAHDFNDYEWGKRHNLEFINILDEDGLLNENAGKYQGLTRFEARKKIVEDLKEEG--------LLVKIEPHTH 338
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489502821 410 PYPHCWRCRNPL-IYRSvSSWFVRVTDFRDRMVEL--NQQITWYPEHVKDgQFGKWLQGARDWSISRNRYWGTPIPVWks 486
Cdd:TIGR00422 339 NVGTCWRSGTVVePLLS-KQWFVKVEKLADKALEAaeEGEIKFVPKRMEK-RYLNWLRNIKDWCISRQLIWGHRIPVW-- 414
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489502821 487 ddpaypridvygsldeLERDFGVrpanlhrpYIDELTRPNPDDPT---GRSTMRRIPDVLDVWFDSGSMPYAQVHYPFEN 563
Cdd:TIGR00422 415 ----------------YCKECGE--------VYVAKEEPLPDDKTntgPSVELEQDTDVLDTWFSSSLWPFSTLGWPDET 470
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489502821 564 LDwFQGHYPGDFIVEYIGQTRGW-FYTLhVLATALFDRPAFKTCVAHGIVLGFDGQKMSKSLRNYPDVTEVFDRDGSDAM 642
Cdd:TIGR00422 471 KD-LKKFYPTDLLVTGYDIIFFWvARMI-FRSLALTGQVPFKEVYIHGLVRDEQGRKMSKSLGNVIDPLDVIEKYGADAL 548
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489502821 643 RWFLmASPILRGGNLIVTEQGIrDGVRQVLLPLWNTYSF--------LALYAPKvgtwrvDSVHVLDRYILAKLAVLRDD 714
Cdd:TIGR00422 549 RFTL-ASLVTPGDDINFDWKRV-ESARNFLNKLWNASRFvlmnlsddLELSGGE------EKLSLADRWILSKLNRTIKE 620
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489502821 715 LSESMEVYDIPGACEHLRQFT-EALTNWYVRRSRSRFWAEDAD----AIDTLHTVLEVTTRLAAPLLPLITEIIWRGL-T 788
Cdd:TIGR00422 621 VRKALDKYRFAEAAKALYEFIwNDFCDWYIELVKYRLYNGNEAekkaARDTLYYVLDKALRLLHPFMPFITEEIWQHFkE 700
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489502821 789 RERSVHLTDWPAPDLLPSDADLVAAMDQVRDVCSAASSLRKAKKLRVRLPLPKLIV--AVENPQLLRPFVDLIGDELNVK 866
Cdd:TIGR00422 701 GADSIMLQSYPVVDAEFVDEEAEKAFELLKEIIVSIRNLKAESNIPPNAPLKVLLIytEAETAERLKLNAVDIKGAINFS 780
|
890 900 910 920
....*....|....*....|....*....|....*....|...
gi 489502821 867 QVELTDAIDTYGRF--ELTVNARVAGPRLG--KDVQAAIKAVK 905
Cdd:TIGR00422 781 EVEVVIEKPEVTEAvvELVPGFEIIIPVKGliNKAKELARLQK 823
|
|
| IleRS_core |
cd00818 |
catalytic core domain of isoleucyl-tRNA synthetases; Isoleucine amino-acyl tRNA synthetases ... |
420-657 |
1.80e-98 |
|
catalytic core domain of isoleucyl-tRNA synthetases; Isoleucine amino-acyl tRNA synthetases (IleRS) catalytic core domain . This class I enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. IleRS has an insertion in the core domain, which is subject to both deletions and rearrangements. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids.
Pssm-ID: 173909 [Multi-domain] Cd Length: 338 Bit Score: 314.17 E-value: 1.80e-98
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489502821 420 PLIYRSVSSWFVRVTDFRDRMVELNQQITWYPEHVKDgQFGKWLQGARDWSISRNRYWGTPIPVWKSDDpaypridvygs 499
Cdd:cd00818 144 PLIYRATPQWFIRVTKIKDRLLEANDKVNWIPEWVKN-RFGNWLENRRDWCISRQRYWGTPIPVWYCED----------- 211
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489502821 500 ldelerdfgvrpanlhrpyideltrpnpddpTGRSTMRRIPDVLDVWFDSGSMPYAQVHYPFENlDWFQGHYPGDFIVEY 579
Cdd:cd00818 212 -------------------------------CGEVLVRRVPDVLDVWFDSGSMPYAQLHYPFEN-EDFEELFPADFILEG 259
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 489502821 580 IGQTRGWFYTLHVLATALFDRPAFKTCVAHGIVLGFDGQKMSKSLRNYPDVTEVFDRDGSDAMRWFLMASPIlRGGNL 657
Cdd:cd00818 260 SDQTRGWFYSLLLLSTALFGKAPYKNVIVHGFVLDEDGRKMSKSLGNYVDPQEVVDKYGADALRLWVASSDV-YAEDL 336
|
|
| IleRS_core |
cd00818 |
catalytic core domain of isoleucyl-tRNA synthetases; Isoleucine amino-acyl tRNA synthetases ... |
44-186 |
2.67e-81 |
|
catalytic core domain of isoleucyl-tRNA synthetases; Isoleucine amino-acyl tRNA synthetases (IleRS) catalytic core domain . This class I enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. IleRS has an insertion in the core domain, which is subject to both deletions and rearrangements. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids.
Pssm-ID: 173909 [Multi-domain] Cd Length: 338 Bit Score: 267.95 E-value: 2.67e-81
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489502821 44 PEYVFYDGPPFANGLPHYGHLLTGYVKDIVPRYRTMRGYKVERRFGWDTHGLPAELEVERQLGITDKSQIEAMGIAAFND 123
Cdd:cd00818 1 PEFVFHDGPPYANGLPHYGHALNKILKDIINRYKTMQGYYVPRRPGWDCHGLPIELKVEKELGISGKKDIEKMGIAEFNA 80
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 489502821 124 ACRASVLRYTDEWQAYVTRQARWVDFDNDYKTLDLAYMESVIWAFKQLWDKGLAYEGYRVLPY 186
Cdd:cd00818 81 KCREFALRYVDEQEEQFQRLGVWVDWENPYKTMDPEYMESVWWVFKQLHEKGLLYRGYKVVPW 143
|
|
| Anticodon_Ia_Ile_ABEc |
cd07961 |
Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA ... |
659-825 |
1.01e-65 |
|
Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; This domain is found in isoleucyl tRNA synthetases (IleRS), which belong to the class Ia aminoacyl tRNA synthetases. It lies C-terminal to the catalytic core domain, and recognizes and specifically binds to the tRNA anticodon. This family includes bacterial, archaeal, and eukaryotic cytoplasmic members. IleRS catalyzes the transfer of isoleucine to the 3'-end of its tRNA.
Pssm-ID: 153415 [Multi-domain] Cd Length: 183 Bit Score: 218.96 E-value: 1.01e-65
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489502821 659 VTEQGIRDGVRQVLLPLWNTYSFLALYA------PKVGTWRVDSVHVLDRYILAKLAVLRDDLSESMEVYDIPGACEHLR 732
Cdd:cd07961 1 FSEKGVREVVRKVLLPLWNAYRFFVTYAnldgfdPGKDDDAVASLNVLDRWILSRLNSLIKEVTEEMEAYDLYTAVRALL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489502821 733 QFTEALTNWYVRRSRSRFWAEDAD-----AIDTLHTVLEVTTRLAAPLLPLITEIIWRGLTR-----ERSVHLTDWPAPD 802
Cdd:cd07961 81 EFIDELTNWYIRRNRKRFWGEEGDddklaAYATLYEVLLTLSRLMAPFTPFITEEIYQNLRRelgdaPESVHLLDWPEVD 160
|
170 180
....*....|....*....|...
gi 489502821 803 LLPSDADLVAAMDQVRDVCSAAS 825
Cdd:cd07961 161 ESLIDEELEEAMELVREIVELGR 183
|
|
| valS |
PRK05729 |
valyl-tRNA synthetase; Reviewed |
60-876 |
1.81e-52 |
|
valyl-tRNA synthetase; Reviewed
Pssm-ID: 235582 [Multi-domain] Cd Length: 874 Bit Score: 199.18 E-value: 1.81e-52
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489502821 60 HYGHLLTGYVKDIVPRYRTMRGYKVERRFGWDTHGLPAELEVERQLGITDKSQiEAMGIAAFndacrasvLRYTDEWQAY 139
Cdd:PRK05729 52 HMGHALNNTLQDILIRYKRMQGYNTLWLPGTDHAGIATQMVVERQLAAEGKSR-HDLGREKF--------LEKVWEWKEE 122
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489502821 140 ----VTRQARW----VDFDNDYKTLDLAYMESVIWAFKQLWDKGLAYEGYRVLPYCWRDETPLSNHELrmdddVYQSRQD 211
Cdd:PRK05729 123 sggtITNQLRRlgasCDWSRERFTMDEGLSKAVREVFVRLYEKGLIYRGKRLVNWDPKLQTALSDLEV-----EYKEVKG 197
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489502821 212 PAVTVGFKVVGGQPdngldgaYLLVWTTTPWTLPSNLAVAVSPDityvqvqagDRRfvlaearlaaYARELGEEpVVLgt 291
Cdd:PRK05729 198 KLWHIRYPLADGSD-------YLVVATTRPETMLGDTAVAVNPE---------DER----------YKHLIGKT-VIL-- 248
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489502821 292 yrgaELLGtRYLPpfayfmdwpnafqVLAGDFVTTDDGTGIVHMAPAYGEDDMVVAEAVGIAPVTPVDSKGRFDVTVADY 371
Cdd:PRK05729 249 ----PLVG-REIP-------------IIADEYVDPEFGTGAVKITPAHDPNDFEVGKRHNLPMINIMDEDGTINENPGEY 310
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489502821 372 QGQHVFDANAQIVRDLKTQsgpaavnGpVLIRHETYEHPYPHCWRCRN---PLIyrsvsS--WFVRVTDFRDRMVEL--N 444
Cdd:PRK05729 311 QGLDRFEARKAIVADLEEL-------G-LLVKIEPHTHSVGHSDRSGVviePYL-----SdqWFVKMKPLAKPALEAveN 377
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489502821 445 QQITWYPEhvkdgQFGK----WLQGARDWSISRNRYWGTPIPVWKSDDPaypriDVYGSLDELErdfgVRPANLhrpyid 520
Cdd:PRK05729 378 GEIKFVPE-----RWEKtyfhWMENIQDWCISRQLWWGHRIPAWYDEDG-----EVYVGREEPE----AREKAL------ 437
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489502821 521 eLTRpnpDdptgrstmrriPDVLDVWFDSGSmpyaqvhYPFENLDW------FQGHYPGDFIVeyigqTrG------W-- 586
Cdd:PRK05729 438 -LTQ---D-----------EDVLDTWFSSAL-------WPFSTLGWpektedLKRFYPTSVLV-----T-GfdiiffWva 489
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489502821 587 ---FYTLHVLatalfDRPAFKTCVAHGIVLGFDGQKMSKSLRNYPDVTEVFDRDGSDAMRWFL--MASPilrGGNLIVTE 661
Cdd:PRK05729 490 rmiMMGLHFT-----GQVPFKDVYIHGLVRDEQGRKMSKSKGNVIDPLDLIDKYGADALRFTLaaLASP---GRDIRFDE 561
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489502821 662 QGIrDGVRQVLLPLWNTYSFLALyapKVGTWRVDSV------HVLDRYILAKLAVLRDDLSESMEVYDIPGACEHLRQFT 735
Cdd:PRK05729 562 ERV-EGYRNFANKLWNASRFVLM---NLEGADVGELpdpeelSLADRWILSRLNRTVAEVTEALDKYRFDEAARALYEFI 637
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489502821 736 -EALTNWYVRRSRSRFWAEDAD-AIDTLHTVLEVTTRLAAPLLPLITEIIWRGLT---RERSVHLTDWPAPDLLpSDADL 810
Cdd:PRK05729 638 wNEFCDWYLELAKPVLQEAAKRaTRATLAYVLEQILRLLHPFMPFITEELWQKLAplgIEESIMLAPWPEADEA-IDEAA 716
|
810 820 830 840 850 860
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 489502821 811 VAAMDQVRDVCSAASSLRKAKKLRVRLPLPKLIVAV--ENPQLLRPFVDLIGDELNVKQVELTDAIDT 876
Cdd:PRK05729 717 EAEFEWLKELITAIRNIRAEMNIPPSKKLPLLLKGAdaEDRARLEANEAYIKRLARLESLEILADDEE 784
|
|
| valS |
PRK14900 |
valyl-tRNA synthetase; Provisional |
26-853 |
5.01e-52 |
|
valyl-tRNA synthetase; Provisional
Pssm-ID: 237855 [Multi-domain] Cd Length: 1052 Bit Score: 199.06 E-value: 5.01e-52
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489502821 26 YWSRDDTFRASIARRDgAPEYVFYDGPPFANGLPHYGHLLTGYVKDIVPRYRTMRGYKVERRFGWDTHGLPAELEVERQL 105
Cdd:PRK14900 31 FWQERGYFHGDEHDRT-RPPFSIVLPPPNVTGSLHLGHALTATLQDVLIRWKRMSGFNTLWLPGTDHAGIATQMIVEKEL 109
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489502821 106 GITDKSQIEAMGIAAFNDacraSVLRYTDEWQAYVTRQARWV----DFDNDYKTLDLAYMESVIWAFKQLWDKGLAYEGY 181
Cdd:PRK14900 110 KKTEKKSRHDLGREAFLE----RVWAWKEQYGSRIGEQHKALgaslDWQRERFTMDEGLSRAVREVFVRLHEEGLIYREK 185
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489502821 182 RVLPYCWRDETPLSNHELRMDddvyQSRQDPAVTVGFKVVGGQPDngldgayLLVWTTTPWTLPSNLAVAVSPDITYVQV 261
Cdd:PRK14900 186 KLINWCPDCRTALSDLEVEHE----EAHQGELWSFAYPLADGSGE-------IVVATTRPETMLGDTAVAVHPLDPRYMA 254
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489502821 262 QAGDRrfvlaeARLAAYARELgeePVVlgtyRGAELLGTRYlppfayfmdwpnafqvlagdfvttddGTGIVHMAPAYGE 341
Cdd:PRK14900 255 LHGKK------VRHPITGRTF---PIV----ADAILVDPKF--------------------------GTGAVKVTPAHDF 295
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489502821 342 DDMVVAEAVGIAPVTPVDSKGRFDVTVADYQGQHVFDANAQIVRDLKTQSgpaavngpVLIRHETYEHPYPHCWRCRNPL 421
Cdd:PRK14900 296 NDFEVGKRHGLEMITVIGPDGRMTAEAGPLAGLDRFEARKEVKRLLAEQG--------LDRGAKPHVLPLGRCQRSATIL 367
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489502821 422 IYRSVSSWFVRVTDFRDRMVELNQQ--ITWYPEHVKDGQFGkWLQGARDWSISRNRYWGTPIPVWKSDDpAYPRIdvygs 499
Cdd:PRK14900 368 EPLLSDQWYVRIEPLARPAIEAVEQgrTRFIPEQWTNTYMA-WMRNIHDWCISRQLWWGHQIPAWYCPD-GHVTV----- 440
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489502821 500 ldelerdfgvrpanlhrpyidelTRPNPDD-PT-GRSTMRRIPDVLDVWFDSGSMPYAQVHYPfENLDWFQGHYPGDfiV 577
Cdd:PRK14900 441 -----------------------ARETPEAcSTcGKAELRQDEDVLDTWFSSGLWPFSTMGWP-EQTDTLRTFYPTS--V 494
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489502821 578 EYIGQTRGWFYTLHVLATALF---DRPaFKTCVAHGIVLGFDGQKMSKSLRNYPDVTEVFDRDGSDAMRwFLMASPILRG 654
Cdd:PRK14900 495 METGHDIIFFWVARMMMMGLHfmgEVP-FRTVYLHPMVRDEKGQKMSKTKGNVIDPLVITEQYGADALR-FTLAALTAQG 572
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489502821 655 GNLIVTEQGIrDGVRQVLLPLWNTYSF----LALYAPKVGTWRVDSVHVLDRYILAKLAVLRDDLSESMEVYDIPGACEH 730
Cdd:PRK14900 573 RDIKLAKERI-EGYRAFANKLWNASRFalmnLSGYQERGEDPARLARTPADRWILARLQRAVNETVEALEAFRFNDAANA 651
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489502821 731 LRQFTEA-LTNWYVRRSRSRFWAEDADAIDTLHTV----LEVTTRLAAPLLPLITEIIWRGLTRER-------SVHLTDW 798
Cdd:PRK14900 652 VYAFVWHeLCDWYIELAKEALASEDPEARRSVQAVlvhcLQTSYRLLHPFMPFITEELWHVLRAQVgasawadSVLAAEY 731
|
810 820 830 840 850 860
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 489502821 799 PAPDLLPSDAD-----LVAAMDQVRDV-----CSAASSLRKAKKLRVRLPLPKLIVAVENPQLLR 853
Cdd:PRK14900 732 PRKGEADEAAEaafrpVLGIIDAVRNIrgemgIPWKVKLGAQAPVEIAVADPALRDLLQAGELAR 796
|
|
| PTZ00419 |
PTZ00419 |
valyl-tRNA synthetase-like protein; Provisional |
25-828 |
8.09e-49 |
|
valyl-tRNA synthetase-like protein; Provisional
Pssm-ID: 240411 [Multi-domain] Cd Length: 995 Bit Score: 188.68 E-value: 8.09e-49
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489502821 25 DYWSRDDTFR-ASIARRDGAPE-YVFYDGPPFANGLPHYGHLLTGYVKDIVPRYRTMRGYKVERRFGWDTHGLPAELEVE 102
Cdd:PTZ00419 39 EWWEKSGFFKpAEDAKSLNSGKkFVIVLPPPNVTGYLHIGHALTGAIQDSLIRYHRMKGDETLWVPGTDHAGIATQVVVE 118
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489502821 103 RQLGITDKSQIEAMGIAAFNDacraSVLRYTDEWQAYVTRQARW----VDFDNDYKTLDLAYMESVIWAFKQLWDKGLAY 178
Cdd:PTZ00419 119 KKLMKEENKTRHDLGREEFLK----KVWEWKDKHGNNICNQLRRlgssLDWSREVFTMDEQRSKAVKEAFVRLYEDGLIY 194
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489502821 179 EGYRVLPYCWRDETPLSNHELRMDDDVYQSR-----QDPAVTVG------FKVVGGqpdnglDGAYLLVWTTTPWTLPSN 247
Cdd:PTZ00419 195 RDTRLVNWCCYLKTAISDIEVEFEEIEKPTKitipgYDKKVEVGvlwhfaYPLEDS------GQEEIVVATTRIETMLGD 268
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489502821 248 LAVAVSPDityvqvqagDRRFvlaearlaayarelgeepvvlgtyrgAELLGTRYLPPFayfmdWPNAFQVLAGD--FVT 325
Cdd:PTZ00419 269 VAVAVHPK---------DERY--------------------------KKLHGKELIHPF-----IPDRKIPIIADdeLVD 308
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489502821 326 TDDGTGIVHMAPAYGEDDMVVAEAVGIAPVTPVDSKGRFDVTVADYQGQHVFDANAQIVRDLKTQSgpaavngpvLIRHE 405
Cdd:PTZ00419 309 MEFGTGAVKITPAHDPNDYEIAKRHNLPFINIFTLDGKINENGGEFAGMHRFDCRRKIEEELKEMG---------LLRDK 379
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489502821 406 T-YEHPYPHCWRCRNPLIYRSVSSWFVRVTDFRDRMVEL--NQQITWYPEHVKDGQFgKWLQGARDWSISRNRYWGTPIP 482
Cdd:PTZ00419 380 VpNPMRLPRCSRSGDIVEPMLIPQWYVNCKDMAKRAVEAvrNGELKIIPSSHENVWY-HWLENIQDWCISRQLWWGHRIP 458
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489502821 483 VWK--SDDPAYPRID-----VYGSLDE-LER---DFGVRPANLhrpyidELTRpnpDdptgrstmrriPDVLDVWFDSGS 551
Cdd:PTZ00419 459 AYRviSKGPETDPSDeepwvVARSEEEaLEKakkKFGLSEEDF------ELEQ---D-----------EDVLDTWFSSGL 518
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489502821 552 MPYAQVHYPFENLDwFQGHYPGDfIVEyIGQTRGWFYT--LHVLATALFDRPAFKTCVAHGIVLGFDGQKMSKSLRNYPD 629
Cdd:PTZ00419 519 FPFSTLGWPDQTDD-LQRFFPTS-LLE-TGSDILFFWVarMVMMSLHLTDKLPFKTVFLHAMVRDSQGEKMSKSKGNVID 595
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489502821 630 VTEVFD-----------------------------RD--------GSDAMRWFLMASPIL-RGGNL----IVteqgirdG 667
Cdd:PTZ00419 596 PLEVIEgislqdlnqklyegnlpekeikraielqkKEfpngipecGTDALRFGLLAYTQQgRNINLdinrVV-------G 668
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489502821 668 VRQVLLPLWNTYSFLALYAPKV---------GTWRVDSVHVLDRYILAKLAVLRDDLSESMEVYDIPGACEHLRQFteal 738
Cdd:PTZ00419 669 YRHFCNKLWNAVKFALMKLLKDfnlpnstlfKPNNVESLPWEDKWILHRLNVAIKEVTEGFKEYDFSEATQATYNF---- 744
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489502821 739 tnW-------YVRRSRSRFWAEDAD-----AIDTLHTVLEVTTRLAAPLLPLITEIIWRGL----TRERSVHLTDWPAPD 802
Cdd:PTZ00419 745 --WlyelcdvYLELIKPRLSKQSDGerkqhAQDVLHTVLDIGLRLLHPMMPFITEELYQRLpnylRKSESISIAKYPQPN 822
|
890 900
....*....|....*....|....*.
gi 489502821 803 LLPSDADLVAAMDQVRDVCSAASSLR 828
Cdd:PTZ00419 823 PGWNNEALDEEMKIIMSIVKSIRSLI 848
|
|
| ValS |
COG0525 |
Valyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Valyl-tRNA synthetase ... |
25-853 |
2.96e-47 |
|
Valyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Valyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 440291 [Multi-domain] Cd Length: 877 Bit Score: 182.94 E-value: 2.96e-47
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489502821 25 DYWSRDDTFRASIARrdgapeyvfyDGPPFANGLP--------HYGHLLTGYVKDIVPRYRTMRGYKVERRFGWDtH-GL 95
Cdd:COG0525 18 QYWEENGYFKADPDS----------DKEPFTIVIPppnvtgslHMGHALNNTLQDILIRYKRMQGYNTLWQPGTD-HaGI 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489502821 96 PAELEVERQL---GITDksqiEAMGIAAFndacrasvLRYTDEWQAY----VTRQARW----VDFDNDYKTLDLAYMESV 164
Cdd:COG0525 87 ATQAVVERQLaeeGKSR----HDLGREKF--------LERVWEWKEEsggtITNQLRRlgasCDWSRERFTMDEGLSKAV 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489502821 165 IWAFKQLWDKGLAYEGYRVLPYCWRDETPLSnhelrmDDDV-YQSRQDPAVTVGFKVVGGQPdngldgaYLLVWTTTPWT 243
Cdd:COG0525 155 REVFVRLYEKGLIYRGKRLVNWDPKLKTALS------DLEVeHEEVKGHLWHIRYPLADGSG-------YIVVATTRPET 221
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489502821 244 LPSNLAVAVSPDityvqvqagDRRfvlaearlaaYARELGEEpVVLgtyrgaELLGtRYLPpfayfmdwpnafqVLAGDF 323
Cdd:COG0525 222 MLGDTAVAVHPE---------DER----------YKHLIGKT-VIL------PLVG-REIP-------------IIADEY 261
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489502821 324 VTTDDGTGIVHMAPAYGEDDMVVAEAVGIAPVTPVDSKGRFDVTVADYQGQHVFDANAQIVRDLKTQsgpaavnGpVLIR 403
Cdd:COG0525 262 VDPEFGTGAVKITPAHDPNDFEVGKRHNLPMINILDEDGTINENAGKYRGLDRFEARKAIVADLEEL-------G-LLVK 333
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489502821 404 HETYEHPYPHCWRCRN---PLIyrsvsS--WFVRVTDFRDRMVE--LNQQITWYPEhvkdgQFGK----WLQGARDWSIS 472
Cdd:COG0525 334 VEPHKHSVGHSDRSGTviePYL-----SdqWFVKMKPLAKPAIEavEDGEIKFVPE-----RWEKtyfhWMENIRDWCIS 403
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489502821 473 RNRYWGTPIPVWKSDDPaypriDVYGSLDELERDFGVRPANLHRpyiDEltrpnpddptgrstmrripDVLDVWFDSGSm 552
Cdd:COG0525 404 RQLWWGHRIPAWYCPDG-----EVYVARTEPEACAKAGSVNLTQ---DE-------------------DVLDTWFSSAL- 455
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489502821 553 pyaqvhYPFENLDW------FQGHYPGDfiveyigqtrgwfytlhVLATA---LF---------------DRPaFKTCVA 608
Cdd:COG0525 456 ------WPFSTLGWpektedLKYFYPTS-----------------VLVTGfdiIFfwvarmimmglhftgEVP-FKDVYI 511
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489502821 609 HGIVLGFDGQKMSKSLRNYPDVTEVFDRDGSDAMRWFL--MASPilrGGNLIVTEQGIrDGVRQVLLPLWNTYSFLALYA 686
Cdd:COG0525 512 HGLVRDEQGRKMSKSKGNVIDPLDLIDKYGADALRFTLaaLASP---GRDIKFDEERV-EGYRNFANKLWNASRFVLMNL 587
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489502821 687 PKVGTWRVDSVHVL---DRYILAKLAVLRDDLSESMEVYDIPGACEHLRQFT--EaLTNWYVRRSRSRFWAEDADAID-- 759
Cdd:COG0525 588 EGFDPGLDPDPEELslaDRWILSRLNKTIAEVTEALEKYRFDEAAQALYDFVwnE-FCDWYLELAKPRLYGGDEAAKRet 666
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489502821 760 --TLHTVLEVTTRLAAPLLPLITEIIWRGLT---RERSVHLTDWPAPDLLPSDADLVAAMDQVRDVCSAASSLRKAKKLR 834
Cdd:COG0525 667 raTLVYVLEQILRLLHPFMPFITEEIWQKLPprkEGESIMLAPWPEADEELIDEEAEAEFEWLKEVISAIRNIRAEMNIP 746
|
890
....*....|....*....
gi 489502821 835 VRLPLPkLIVAVENPQLLR 853
Cdd:COG0525 747 PSKKLP-LLLKGADEADRA 764
|
|
| PLN02943 |
PLN02943 |
aminoacyl-tRNA ligase |
20-828 |
4.74e-45 |
|
aminoacyl-tRNA ligase
Pssm-ID: 215509 [Multi-domain] Cd Length: 958 Bit Score: 176.67 E-value: 4.74e-45
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489502821 20 ELEVLDYWSRDDTFRASIARrdGAPEYVFYDGPPFANGLPHYGHLLTGYVKDIVPRYRTMRGYKVERRFGWDTHGLPAEL 99
Cdd:PLN02943 66 EERIYNWWESQGYFKPNFDR--GGDPFVIPMPPPNVTGSLHMGHAMFVTLEDIMVRYNRMKGRPTLWIPGTDHAGIATQL 143
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489502821 100 EVERQLGITDKSQIEaMGIAAFNDacraSVLRYTDEWQAYVTRQARWV----DFDNDYKTLDLAYMESVIWAFKQLWDKG 175
Cdd:PLN02943 144 VVEKMLASEGIKRTD-LGRDEFTK----RVWEWKEKYGGTITNQIKRLgascDWSRERFTLDEQLSRAVVEAFVRLHEKG 218
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489502821 176 LAYEGYRVLPYCWRDETPLSNHELRmdddvYQSRQDPAVTVGFKVVGGQPDngldgaYLLVWTTTPWTLPSNLAVAVSPD 255
Cdd:PLN02943 219 LIYQGSYMVNWSPNLQTAVSDLEVE-----YSEEPGTLYYIKYRVAGGSED------FLTIATTRPETLFGDVAIAVNPE 287
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489502821 256 ityvqvqagDRRfvlaearlaaYARELGEEPVVLGTYrgaellgTRYLPpfayfmdwpnafqVLAGDFVTTDDGTGIVHM 335
Cdd:PLN02943 288 ---------DDR----------YSKYIGKMAIVPMTY-------GRHVP-------------IIADRYVDKDFGTGVLKI 328
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489502821 336 APAYGEDDMVVAEAVGIaPVTPVDSKgrfDVTVADYQGQHVFDANAQIVRDLKtQSGPAavngpvlIRHETYEHPYPHCW 415
Cdd:PLN02943 329 SPGHDHNDYLLARKLGL-PILNVMNK---DGTLNEVAGLYWFEAREKLWSDLE-ETGLA-------VKKEPHTLRVPRSQ 396
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489502821 416 R---CRNPLIYRSvssWFVRVTDFRDRMVEL--NQQITWYPEHVKDgQFGKWLQGARDWSISRNRYWGTPIPVWKsddpa 490
Cdd:PLN02943 397 RggeVIEPLVSKQ---WFVTMEPLAEKALKAveNGELTIIPERFEK-IYNHWLSNIKDWCISRQLWWGHRIPVWY----- 467
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489502821 491 ypridVYGSldELERDFGV-RPANlhrpyiDELTRPNpdDPTGRST-MRRIPDVLDVWFDSGSMPYAQVHYPFENLDWFQ 568
Cdd:PLN02943 468 -----IVGK--DCEEDYIVaRSAE------EALEKAR--EKYGKDVeIYQDPDVLDTWFSSALWPFSTLGWPDVSAEDFK 532
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489502821 569 GHYPGDFIVEYIGQTRGWFYTLHVLATALFDRPAFKTCVAHGIVLGFDGQKMSKSLRNYPDVTEVFDRDGSDAMRWFLMA 648
Cdd:PLN02943 533 KFYPTTVLETGHDILFFWVARMVMMGIEFTGTVPFSYVYLHGLIRDSQGRKMSKTLGNVIDPLDTIKEFGTDALRFTLAL 612
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489502821 649 SPILRGGNLiVTEQGIRDgvRQVLLPLWNTYSFLALYAPK---VGTWRVDSVHVLD------------RYILAKLAVLRD 713
Cdd:PLN02943 613 GTAGQDLNL-STERLTSN--KAFTNKLWNAGKFVLQNLPSqsdTSAWEHILACKFDkeesllslplpeCWVVSKLHELID 689
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489502821 714 DLSESMEVYDIPGACEHLRQFTEA-LTNWYVRRSRSRFW-AEDADAIDTLHTVL----EVTTRLAAPLLPLITEIIWRGL 787
Cdd:PLN02943 690 SVTTSYDKYFFGDVGREIYDFFWSdFADWYIEASKTRLYhSGDNSALSRAQAVLlyvfENILKLLHPFMPFVTEELWQAL 769
|
810 820 830 840
....*....|....*....|....*....|....*....|..
gi 489502821 788 T-RERSVHLTDWPAPDlLPSDADLVAAMDQVRDVCSAASSLR 828
Cdd:PLN02943 770 PyRKEALIVSPWPQTS-LPKDLKSIKRFENLQSLTRAIRNAR 810
|
|
| ValRS_core |
cd00817 |
catalytic core domain of valyl-tRNA synthetases; Valine amino-acyl tRNA synthetase (ValRS) ... |
414-649 |
2.85e-39 |
|
catalytic core domain of valyl-tRNA synthetases; Valine amino-acyl tRNA synthetase (ValRS) catalytic core domain. This enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. ValRS has an insertion in the core domain, which is subject to both deletions and rearrangements. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids.
Pssm-ID: 185677 [Multi-domain] Cd Length: 382 Bit Score: 150.47 E-value: 2.85e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489502821 414 CWRCRNPLIYRSVSSWFVRVTDFRDRMVEL--NQQITWYPEHVKDgQFGKWLQGARDWSISRNRYWGTPIPVWKSDDPAY 491
Cdd:cd00817 156 CSRSGDVIEPLLKPQWFVKVKDLAKKALEAvkEGDIKFVPERMEK-RYENWLENIRDWCISRQLWWGHRIPAWYCKDGGH 234
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489502821 492 pridVYGSLDELERDfgvrpanlhrpyidELTRPNPDDPTGRSTMRRIPDVLDVWFDSGSMPYAQVHYPfENLDWFQGHY 571
Cdd:cd00817 235 ----WVVAREEDEAI--------------DKAAPEACVPCGGEELKQDEDVLDTWFSSSLWPFSTLGWP-EETKDLKKFY 295
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489502821 572 PGDFIVEyiGQ--TRGW-FYTLhVLATALFDRPAFKTCVAHGIVLGFDGQKMSKSLRNYPDVTEVFDRDGSDAMRWFLMA 648
Cdd:cd00817 296 PTSLLVT--GHdiIFFWvARMI-MRGLKLTGKLPFKEVYLHGLVRDEDGRKMSKSLGNVIDPLDVIDGYGADALRFTLAS 372
|
.
gi 489502821 649 S 649
Cdd:cd00817 373 A 373
|
|
| Ile_Leu_Val_MetRS_core |
cd00668 |
catalytic core domain of isoleucyl, leucyl, valyl and methioninyl tRNA synthetases; Catalytic ... |
428-649 |
6.65e-39 |
|
catalytic core domain of isoleucyl, leucyl, valyl and methioninyl tRNA synthetases; Catalytic core domain of isoleucyl, leucyl, valyl and methioninyl tRNA synthetases. These class I enzymes are all monomers. However, in some species, MetRS functions as a homodimer, as a result of an additional C-terminal domain. These enzymes aminoacylate the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. Enzymes in this subfamily share an insertion in the core domain, which is subject to both deletions and rearrangements. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids. MetRS has a significantly shorter insertion, which lacks the editing function.
Pssm-ID: 185674 [Multi-domain] Cd Length: 312 Bit Score: 147.57 E-value: 6.65e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489502821 428 SWFVRVTDFRDRMVELNQQITWYPEHVKDgQFGKWLQGARDWSISRNRYWGTPIPvwksddpaypridvygsldelerdf 507
Cdd:cd00668 141 QWFFDMPKFKEKLLKALRRGKIVPEHVKN-RMEAWLESLLDWAISRQRYWGTPLP------------------------- 194
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489502821 508 gvrpanlhrpyideltrpnpddptgrstmrriPDVLDVWFDSGSMPYAQVHYPFENlDWFQGHYPGDFIVEYIGQTRGWF 587
Cdd:cd00668 195 --------------------------------EDVFDVWFDSGIGPLGSLGYPEEK-EWFKDSYPADWHLIGKDILRGWA 241
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 489502821 588 YTLHVLATALFDRPAFKTCVAHGIVLGFDGQKMSKSLRNYPDVTEVFDRDGSDAMRWFLMAS 649
Cdd:cd00668 242 NFWITMLVALFGEIPPKNLLVHGFVLDEGGQKMSKSKGNVIDPSDVVEKYGADALRYYLTSL 303
|
|
| Ile_Leu_Val_MetRS_core |
cd00668 |
catalytic core domain of isoleucyl, leucyl, valyl and methioninyl tRNA synthetases; Catalytic ... |
46-183 |
1.02e-34 |
|
catalytic core domain of isoleucyl, leucyl, valyl and methioninyl tRNA synthetases; Catalytic core domain of isoleucyl, leucyl, valyl and methioninyl tRNA synthetases. These class I enzymes are all monomers. However, in some species, MetRS functions as a homodimer, as a result of an additional C-terminal domain. These enzymes aminoacylate the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. Enzymes in this subfamily share an insertion in the core domain, which is subject to both deletions and rearrangements. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids. MetRS has a significantly shorter insertion, which lacks the editing function.
Pssm-ID: 185674 [Multi-domain] Cd Length: 312 Bit Score: 135.24 E-value: 1.02e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489502821 46 YVFYDGPPFANGLPHYGHLLTGYVKDIVPRYRTMRGYKVERRFGWDTHGLPAELEVERQLGITDKSQIeamgIAAFNDAC 125
Cdd:cd00668 2 FYVTTPPPYANGSLHLGHALTHIIADFIARYKRMRGYEVPFLPGWDTHGLPIELKAERKGGRKKKTIW----IEEFREDP 77
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*...
gi 489502821 126 RASVLRYTDEWQAYVTRQARWVDFDNDYKTLDLAYMESVIWAFKQLWDKGLAYEGYRV 183
Cdd:cd00668 78 KEFVEEMSGEHKEDFRRLGISYDWSDEYITTEPEYSKAVELIFSRLYEKGLIYRGTHP 135
|
|
| PLN02381 |
PLN02381 |
valyl-tRNA synthetase |
26-838 |
2.08e-31 |
|
valyl-tRNA synthetase
Pssm-ID: 215214 [Multi-domain] Cd Length: 1066 Bit Score: 133.49 E-value: 2.08e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489502821 26 YWSRDDTFRASIArrDGAPEYVFYDGPPFANGLPHYGHLLTGYVKDIVPRYRTMRGYKVERRFGWDTHGLPAELEVERQL 105
Cdd:PLN02381 112 WWEKSGYFGADAK--SSKPPFVIVLPPPNVTGALHIGHALTAAIEDTIIRWKRMSGYNALWVPGVDHAGIATQVVVEKKL 189
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489502821 106 GITDKSQIEAMGIAAFndacRASVLRYTDEWQAYVTRQARWV----DFDNDYKTLDLAYMESVIWAFKQLWDKGLAYEGY 181
Cdd:PLN02381 190 MRERHLTRHDIGREEF----VSEVWKWKDEYGGTILNQLRRLgaslDWSRECFTMDEQRSKAVTEAFVRLYKEGLIYRDI 265
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489502821 182 RVLPYCWRDETPLSNHELRMDDDVYQSRQ-----DPAVTVGFKVVGGQPDNGlDGAYLLVWTTTPWTLPSNLAVAVSPDi 256
Cdd:PLN02381 266 RLVNWDCTLRTAISDVEVDYIDIKERTLLkvpgyDKPVEFGVLTSFAYPLEG-GLGEIVVATTRIETMLGDTAIAIHPD- 343
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489502821 257 tyvqvqagDRRFVLAEARLAAYArelgeepvvlgtYRGaellgtRYLPPfayfmdwpnafqVLAGDFVTTDDGTGIVHMA 336
Cdd:PLN02381 344 --------DERYKHLHGKFAVHP------------FNG------RKLPI------------ICDAILVDPNFGTGAVKIT 385
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489502821 337 PAYGEDDMVVAEAVGIAPVTPVDSKGRFDVTV-ADYQGQHVFDANAQIVRDLKTQSgpaavngpvLIRH-ETYEHPYPHC 414
Cdd:PLN02381 386 PAHDPNDFEVGKRHNLEFINIFTDDGKINSNGgSEFAGMPRFAAREAVIEALQKKG---------LYRGaKNNEMRLGLC 456
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489502821 415 WRCRN---PLIYrsvSSWFVRVTDFRDRMVEL-----NQQITWYPEHVkDGQFGKWLQGARDWSISRNRYWGTPIPVWks 486
Cdd:PLN02381 457 SRTNDvvePMIK---PQWFVNCSSMAKQALDAaidgeNKKLEFIPKQY-LAEWKRWLENIRDWCISRQLWWGHRIPAW-- 530
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489502821 487 ddpaypridvYGSL-DELERDFGVrpANLH----RPYIDELTRPNPDDPTGRSTMRRIPDVLDVWFDSGSMPYAQVHYPf 561
Cdd:PLN02381 531 ----------YVTLeDDQLKELGS--YNDHwvvaRNESDALLEASQKFPGKKFELSQDPDVLDTWFSSGLFPLSVLGWP- 597
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489502821 562 ENLDWFQGHYPGDFIVEYIGQTRGWFYTLHVLATALFDRPAFKTCVAHGIVLGFDGQKMSKSLRNYPDVTEVFD------ 635
Cdd:PLN02381 598 DDTDDLKAFYPTSVLETGHDILFFWVARMVMMGMQLGGDVPFRKVYLHPMIRDAHGRKMSKSLGNVIDPLEVINgisleg 677
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489502821 636 -----------------------RD--------GSDAMRwFLMASPILRGGNLIVTEQGIRdGVRQVLLPLWNTYSFL-- 682
Cdd:PLN02381 678 lhkrleegnldpkelvvakegqkKDfpngiaecGTDALR-FALVSYTAQSDKINLDILRVV-GYRQWCNKLWNAVRFAms 755
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489502821 683 ---ALYAPKVgTWRVDSVHVLDRYILAKLAVLRDDLSESMEVYDIPGACEHLRQ---------FTEALTNWYVRRSRSrF 750
Cdd:PLN02381 756 klgDDYTPPA-TLSVETMPFSCKWILSVLNKAISKTVSSLDAYEFSDAASTVYSwwqyqfcdvFIEAIKPYFAGDNPE-F 833
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489502821 751 WAEDADAIDTLHTVLEVTTRLAAPLLPLITEIIW------RGLTRERSVHLTDWPAPDLLPSDADLVAAMDQVRDVCSAA 824
Cdd:PLN02381 834 ASERAAAQDTLWICLDTGLRLLHPFMPFVTEELWqrlpqpKDHTRKDSIMISEYPSAVEAWTNEKVEYEMDLVLSTVKCL 913
|
890
....*....|....*..
gi 489502821 825 SSLRKA---KKLRVRLP 838
Cdd:PLN02381 914 RSLRAEvleKQKNERLP 930
|
|
| leuS |
PRK12300 |
leucyl-tRNA synthetase; Reviewed |
59-868 |
8.59e-30 |
|
leucyl-tRNA synthetase; Reviewed
Pssm-ID: 237049 [Multi-domain] Cd Length: 897 Bit Score: 127.68 E-value: 8.59e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489502821 59 PHYGHLLTGYVKDIVPRYRTMRGYKVERRFGWDTHGLP----AELEVERqlgitDKSQIEAMGiaafndacraSVLRYTD 134
Cdd:PRK12300 1 LHVGHGRTYTIGDVIARYKRMRGYNVLFPMAFHVTGTPilgiAERIARG-----DPETIELYK----------SLYGIPE 65
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489502821 135 EWQAYVTRQARWVD-FDNDYK-----------------TLDLAYMESVIWAFKQLWDKGLAYEG-YRVLpYCWRDETPLS 195
Cdd:PRK12300 66 EELEKFKDPEYIVEyFSEEAKedmkrigysidwrreftTTDPEYSKFIEWQFRKLKEKGLIVKGsHPVR-YCPNDNNPVG 144
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489502821 196 NHELRMDDDvyqsrqdpaVTVG------FKvvggqpdnGLDGAYLLVWTTTPWTLPSNLAVAVSPDITYVQVQAGDRRFV 269
Cdd:PRK12300 145 DHDLLDGEE---------PEIVeytlikFE--------ESEDLILPAATLRPETIFGVTNLWVNPDATYVKAEVDGEKWI 207
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489502821 270 LAEArlAAYarEL---GEEPVVLGTYRGAELLGTRYLPPFAyfMDW-PnafqVLAGDFVTTDDGTGIVHMAPAYG----- 340
Cdd:PRK12300 208 VSKE--AAE--KLsfqDRDVEIIEEIKGSELIGKKVKNPVT--GKEvP----ILPADFVDPDNGTGVVMSVPAHApydyv 277
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489502821 341 -----EDDMVVAEAVGIAPVTPVD------------------------------------SKGRFDVTVADYQGQHVFDA 379
Cdd:PRK12300 278 alrdlKKNKELLDVIEPIPLIEVEgygefpakevveklgiksqedpeleeatkevyraefHKGVLKENTGEYAGKPVREA 357
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489502821 380 NAQIVRDLKtQSGPAAV-----NGPVLirhetyehpyphCwRCRNPLIYRSVS-SWFVRVTD--FRDRMVELNQQITWYP 451
Cdd:PRK12300 358 REKITKDLI-EKGIADImyefsNRPVY------------C-RCGTECVVKVVKdQWFIDYSDpeWKELAHKALDNMEIIP 423
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489502821 452 EHVKDgQFGK---WLqgaRDWSISRNRYWGTPIPvWK--------SDDPAYPridVYGSLDELERDFGVRPANLhrpyID 520
Cdd:PRK12300 424 EEYRK-EFENtidWL---KDRACARRRGLGTRLP-WDeewiieslSDSTIYM---AYYTIAHKIREYGIKPEQL----TP 491
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489502821 521 E------LTRPNPDDPTGRS--------TMRRipdVLDVWfdsgsmpyaqvhYPfenLDW-------FQGHYPgdfivey 579
Cdd:PRK12300 492 EffdyvfLGKGDPEEVSKKTgipkeileEMRE---EFLYW------------YP---VDWrhsgkdlIPNHLT------- 546
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489502821 580 igqtrgwFYTLHvlATALFDR---PafktcvaHGIVL-GF---DGQKMSKSLRNYPDVTEVFDRDGSDAMRWFLMASPIL 652
Cdd:PRK12300 547 -------FFIFN--HVAIFPEekwP-------RGIVVnGFvllEGKKMSKSKGNVIPLRKAIEEYGADVVRLYLTSSAEL 610
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489502821 653 rGGNLIVTEQGIRdGVRQVLlplwntYSFLALYAPKVGTWRVDSVHVLDRYILAKLAVLRDDLSESMEVYDIPGACEHLR 732
Cdd:PRK12300 611 -LQDADWREKEVE-SVRRQL------ERFYELAKELIEIGGEEELRFIDKWLLSRLNRIIKETTEAMESFQTRDAVQEAF 682
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489502821 733 QFTEALTNWYVRRSrsrfwaeDADAIDTLHTVLEVTTRLAAPLLPLITEIIWRGLTRERSVHLTDWPAPDLLPSDADLVA 812
Cdd:PRK12300 683 YELLNDLRWYLRRV-------GEANNKVLREVLEIWIRLLAPFTPHLAEELWHKLGGEGFVSLEKWPEPDESKIDEEAEL 755
|
890 900 910 920 930
....*....|....*....|....*....|....*....|....*....|....*.
gi 489502821 813 AMDQVRDVCSAASSLRKAKKLRvrlplPKLIVAVENPQLLRPFVDLIGDELNVKQV 868
Cdd:PRK12300 756 AEEYVKRLIEDIREILKVAKIK-----PKKVYIYVAPDWKYEVLEIAAENGDVKEA 806
|
|
| DUF5915 |
pfam19302 |
Domain of unknown function (DUF5915); This presumed domain is found at the C-terminus of ... |
857-1040 |
6.01e-29 |
|
Domain of unknown function (DUF5915); This presumed domain is found at the C-terminus of isoleucyl tRNA ligase enzymes.
Pssm-ID: 437134 [Multi-domain] Cd Length: 195 Bit Score: 114.88 E-value: 6.01e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489502821 857 DLIGDELNVKQVELTDAIDTYGRFELTVNARVAGPRLGKDV-----------QAAIKAVKAGDGV-INPDGTllagPAVL 924
Cdd:pfam19302 2 DIIKEELNVKEVEFGADESELVEYSAKPNFPVLGKELGKLMkaaakeiaslnQMEIQKILDGGTLtIDVDGE----EIEL 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489502821 925 TPDeynSRLVAADP-ESTAALPDGAGLVVLDGTVTAELEAEGWAKDRIRELQELRKSTGLDVSDRIRVVMSVPAEREDWA 1003
Cdd:pfam19302 78 TSE---DLLVTRQGkEGLAVANEGTLTVALDTTITEELREEGLVREIVSKIQNLRKESGFEVTDRINLYVSGNEMLEAAI 154
|
170 180 190 200
....*....|....*....|....*....|....*....|
gi 489502821 1004 RTHRDLIAGEILATDFEFADLADG--VAIGDG-VRVSIEK 1040
Cdd:pfam19302 155 EKFEDYIKKETLAVEIIFNEEKEYteVDINGEkLKIAVEK 194
|
|
| leuS_bact |
TIGR00396 |
leucyl-tRNA synthetase, eubacterial and mitochondrial family; The leucyl-tRNA synthetases ... |
18-677 |
1.62e-28 |
|
leucyl-tRNA synthetase, eubacterial and mitochondrial family; The leucyl-tRNA synthetases belong to two families so broadly different that they are represented by separate models. This model includes both eubacterial and mitochondrial leucyl-tRNA synthetases. It generates higher scores for some valyl-tRNA synthetases than for any archaeal or eukaryotic cytosolic leucyl-tRNA synthetase. Note that the enzyme from Aquifex aeolicus is split into alpha and beta chains; neither chain is long enough to score above the trusted cutoff, but the alpha chain scores well above the noise cutoff. The beta chain must be found by a model and search designed for partial length matches. [Protein synthesis, tRNA aminoacylation]
Pssm-ID: 273057 [Multi-domain] Cd Length: 842 Bit Score: 123.32 E-value: 1.62e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489502821 18 ALELEVLDYWSRDDTFRASIArrDGAPEYVFYDGPPFANGLPHYGHLLTGYVKDIVPRYRTMRGYKVERRFGWDTHGLPA 97
Cdd:TIGR00396 5 EIEEKWQQKWDENKTFKVTDD--SSKPKYYILSMFPYPSGALHMGHVRNYTITDVLSRYYRMKGYNVLHPIGWDAFGLPA 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489502821 98 E-LEVERqlGITDKSqieamgiaafndacrasvlrYTDEWQAYVTRQARWVDFDNDY----KTLDLAYMESVIWAFKQLW 172
Cdd:TIGR00396 83 EnAAIKR--GIHPAK--------------------WTYENIANMKKQLQALGFSYDWdreiATCDPEYYKWTQWIFLELF 140
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489502821 173 DKGLAYEGYRVLPYCWRDETPLSNHELRMD------------------------------DDVYQSRQDP---------- 212
Cdd:TIGR00396 141 EKGLAYVKEADVNWCPNDGTVLANEQVDSDgrswrgdtpvekkelkqwflkitayaeellNDLEELDHWPesvkemqrnw 220
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489502821 213 -----AVTVGFKVVGGQPDngldgayLLVWTTTPWTLPSNLAVAVSPDITYVQVQAGdrrfvlAEARLAAYARELGEEPV 287
Cdd:TIGR00396 221 igkseGVEITFKIADHDEK-------ITVFTTRPDTIFGVTYLALAPEHPLVEKAAE------NNPKVAAFIKKILNKTV 287
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489502821 288 VLGT-----YRGAeLLGTRYLPPFAyfmdwPNAFQVLAGDFVTTDDGTGIVHMAPAYGEDDMVVAEAVGIaPVTPVDSKG 362
Cdd:TIGR00396 288 AERTkatkeKKGV-DTGIKAIHPLT-----GEKIPIWVANYVLMEYGTGAVMGVPAHDERDFEFAQKYGL-PIKPVIDPA 360
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489502821 363 RFDVTVADYQGQHVFDANAQIVRDLKTQsgpaavngpvlirhetyehpyphcwrcrnpliyrsvsswfvrvtdfrdrmvE 442
Cdd:TIGR00396 361 EKDLSLTAAYTEDGVLVNSGEFNGLNSS---------------------------------------------------E 389
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489502821 443 LNQQITWYPEHVKDGQfGKWLQGARDWSISRNRYWGTPIPVWKSDDP---AYPRIDVYGSLDELERDFGVRPANLHRpyI 519
Cdd:TIGR00396 390 ARNAIIDMLEKEGKGK-RKVNYRLRDWGFSRQRYWGEPIPIIHCEDGgvvPVPEEDLPVILPEDVVYDGDGGSPLSR--I 466
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489502821 520 DE---LTRPNPDDPTGRSTmrripDVLDVWFDSG--SMPYAQVHYP--FENLDWFQGHYPGDFiveYIGQTRgwFYTLHV 592
Cdd:TIGR00396 467 PEwvnVTCPSCGKPALRET-----DTMDTFAGSSwyYLRYLDPKNTdgPFDKEKAEYWLPVDL---YIGGIE--HAILHL 536
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489502821 593 L-----ATALFDRPA------FKTCVAHGIVLGF-------------------------------DGQKMSKSLRNYPDV 630
Cdd:TIGR00396 537 LyarffHKFLRDIGYvntkepFKKLINQGMVLGFyyppngkvpadvlterdekgkdkaggelvyvGYEKMSKSKGNGIDP 616
|
730 740 750 760
....*....|....*....|....*....|....*....|....*...
gi 489502821 631 TEVFDRDGSDAMRWFLM-ASPIlrGGNLIVTEQGIrDGVRQVLLPLWN 677
Cdd:TIGR00396 617 QEIVESYGADALRLFIMfMGPI--AASLEWNESGL-EGARRFLDRVWN 661
|
|
| Anticodon_1 |
pfam08264 |
Anticodon-binding domain of tRNA ligase; This domain is found mainly hydrophobic tRNA ... |
701-843 |
4.22e-26 |
|
Anticodon-binding domain of tRNA ligase; This domain is found mainly hydrophobic tRNA synthetases. The domain binds to the anticodon of the tRNA ligase.
Pssm-ID: 400523 [Multi-domain] Cd Length: 141 Bit Score: 104.79 E-value: 4.22e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489502821 701 DRYILAKLAVLRDDLSESMEVYDIPGACEHLRQF-TEALTNWYVRRSRSRFWAEDAD--AIDTLHTVLEVTTRLAAPLLP 777
Cdd:pfam08264 1 DRWILSRLNKLIKEVTEAYENYRFNTAAQALYEFfWNDLSDWYLELIKDRLYGEEPDsrAQTTLYEVLETLLRLLAPFMP 80
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 489502821 778 LITEIIWrgltRERSVHLTDWPAPDLLPsDADLVAAMDQVRDVCSAASSLRKAKKLRVRLPLPKLI 843
Cdd:pfam08264 81 FITEELW----QKESIHLAPWPEDAELE-EAELEEAFELRQEIVQAIRKLRSELKIKKSLPLEVVI 141
|
|
| ValRS_core |
cd00817 |
catalytic core domain of valyl-tRNA synthetases; Valine amino-acyl tRNA synthetase (ValRS) ... |
52-198 |
9.90e-22 |
|
catalytic core domain of valyl-tRNA synthetases; Valine amino-acyl tRNA synthetase (ValRS) catalytic core domain. This enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. ValRS has an insertion in the core domain, which is subject to both deletions and rearrangements. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids.
Pssm-ID: 185677 [Multi-domain] Cd Length: 382 Bit Score: 98.47 E-value: 9.90e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489502821 52 PPFANGLPHYGHLLTGYVKDIVPRYRTMRGYKVERRFGWDTHGLPAELEVERQLGITDKSQIEaMGIAAFNDACrasvLR 131
Cdd:cd00817 9 PPNVTGSLHMGHALNNTIQDIIARYKRMKGYNVLWPPGTDHAGIATQVVVEKKLGIEGKTRHD-LGREEFLEKC----WE 83
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 489502821 132 YTDEWQAYVTRQARW----VDFDNDYKTLDLAYMESVIWAFKQLWDKGLAYEGYRVLPYCWRDETPLSNHE 198
Cdd:cd00817 84 WKEESGGKIREQLKRlgasVDWSREYFTMDPGLSRAVQEAFVRLYEKGLIYRDNRLVNWCPKLRTAISDIE 154
|
|
| Anticodon_Ia_Ile_BEm |
cd07960 |
Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; ... |
675-820 |
2.17e-15 |
|
Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; This domain is found in isoleucyl tRNA synthetases (IleRS), which belong to the class Ia aminoacyl tRNA synthetases. It lies C-terminal to the catalytic core domain, and recognizes and specifically binds to the tRNA anticodon. This family includes bacterial and eukaryotic mitochondrial members. IleRS catalyzes the transfer of isoleucine to the 3'-end of its tRNA.
Pssm-ID: 153414 [Multi-domain] Cd Length: 180 Bit Score: 75.25 E-value: 2.17e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489502821 675 LWNTYSF----LALYAPKVGTWRVDSVHVLDRYILAKLAVLRDDLSESMEVYDIPGACEHLRQF-TEALTNWYVRRSRSR 749
Cdd:cd07960 16 IRNTFRFllgnLNDFDPAKDAVPYEELLELDRYALHRLNELIKEVREAYENYEFHKVYQALNNFcTVDLSAFYLDIIKDR 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489502821 750 FWAEDADAID------TLHTVLEVTTRLAAPLLPLITEIIWR---GLTRERSVHLTDWPAPDLLPSDADLVAAMDQVRDV 820
Cdd:cd07960 96 LYCDAKDSLErrsaqtVLYHILDALLKLLAPILPFTAEEVWEhlpGEKKEESVFLEDWPELPEEWKDEELEEKWEKLLAL 175
|
|
| Anticodon_Ia_Val |
cd07962 |
Anticodon-binding domain of valyl tRNA synthetases; This domain is found in valyl tRNA ... |
675-787 |
2.28e-15 |
|
Anticodon-binding domain of valyl tRNA synthetases; This domain is found in valyl tRNA synthetases (ValRS), which belong to the class Ia aminoacyl tRNA synthetases. It lies C-terminal to the catalytic core domain, and recognizes and specifically binds to the tRNA anticodon. ValRS catalyzes the transfer of valine to the 3'-end of its tRNA.
Pssm-ID: 153416 [Multi-domain] Cd Length: 135 Bit Score: 73.74 E-value: 2.28e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489502821 675 LWNTYSFLALYAP--KVGTWRVDSVHVLDRYILAKLAVLRDDLSESMEVYDIPGACEHLRQFT-EALTNWYVRRSRSRFW 751
Cdd:cd07962 16 LWNAARFVLMNLEddDEPEEDPESLSLADRWILSRLNKTVEEVTEALENYRFSEAATALYEFFwNDFCDWYLELVKPRLY 95
|
90 100 110 120
....*....|....*....|....*....|....*....|
gi 489502821 752 AEDAD----AIDTLHTVLEVTTRLAAPLLPLITEIIWRGL 787
Cdd:cd07962 96 GEDEEekkaARATLYYVLETILRLLHPFMPFITEELWQRL 135
|
|
| PLN02563 |
PLN02563 |
aminoacyl-tRNA ligase |
26-488 |
2.18e-14 |
|
aminoacyl-tRNA ligase
Pssm-ID: 178177 [Multi-domain] Cd Length: 963 Bit Score: 77.94 E-value: 2.18e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489502821 26 YWSRDDTFRASIARRDGAPEYVFYDGPPFANGLP-HYGHLLtGYV-KDIVPRYRTMRGYKVERRFGWDTHGLPAElever 103
Cdd:PLN02563 92 YWEENRTFRTPDDVDTSKPKFYVLDMFPYPSGAGlHVGHPE-GYTaTDILARYKRMQGYNVLHPMGWDAFGLPAE----- 165
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489502821 104 QLGI---TDKSQIEAMGIAAFNDACRASVLRYtdewqayvtrqarwvDFDNDYKTLDLAYMESVIWAFKQLWDKGLAYEG 180
Cdd:PLN02563 166 QYAIetgTHPKITTLKNIARFRSQLKSLGFSY---------------DWDREISTTEPEYYKWTQWIFLQLLKRGLAYQA 230
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489502821 181 YRVLPYCWRDETPLSNHEL------RMDDDV--------------YQSR--QD------PAVT---------------VG 217
Cdd:PLN02563 231 EVPVNWCPALGTVLANEEVvdglseRGGHPVirkpmrqwmlkitaYADRllEDlddldwPESIkemqrnwigrsegaeLD 310
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489502821 218 FKVVGGqpDNGLDGAYLLVWTTTPWTLPSNLAVAVSPDITYVQVQAGDRRFVLAEARLAAYAR-------ELGEEP--VV 288
Cdd:PLN02563 311 FSVLDG--EGKERDEKITVYTTRPDTLFGATYLVVAPEHPLLSSLTTAEQKEAVEEYVDAASRksdlertELQKEKtgVF 388
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489502821 289 LGTYRGAELLGtrylppfayfmdwpNAFQVLAGDFVTTDDGTGIVHMAPAYGEDDMVVAEAVGIA---PVTPVDskGRFD 365
Cdd:PLN02563 389 TGSYAINPATG--------------EAIPIWVADYVLGSYGTGAIMAVPAHDTRDFEFAQKFDLPikwVVKPAD--GNED 452
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489502821 366 VTVADYQGQHVFDANAQIVRDLKTQSGPAAVngpvlirhetyehpyphcwrcrnpliyRSVSSWFvrvtdfrDRMVELNQ 445
Cdd:PLN02563 453 DAEKAYTGEGVIVNSSSSGLDINGLSSKEAA---------------------------KKVIEWL-------EETGNGKK 498
|
490 500 510 520
....*....|....*....|....*....|....*....|...
gi 489502821 446 QITWypehvkdgqfgkwlqGARDWSISRNRYWGTPIPVWKSDD 488
Cdd:PLN02563 499 KVNY---------------KLRDWLFARQRYWGEPIPVVFLED 526
|
|
| LeuS |
COG0495 |
Leucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Leucyl-tRNA ... |
467-802 |
1.26e-13 |
|
Leucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Leucyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 440261 [Multi-domain] Cd Length: 826 Bit Score: 75.47 E-value: 1.26e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489502821 467 RDWSISRNRYWGTPIPVWKSDD------PAypridvygslDELerdfgvrPANLhrPYIDELtrpnpdDPTGRSTMRRIP 540
Cdd:COG0495 420 RDWLISRQRYWGEPIPIIHCEDcgvvpvPE----------DQL-------PVEL--PEDVDF------DPTGGSPLARAP 474
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489502821 541 ------------------DVLDVWFDSgS---MPYAQVHY---PF--ENLD-WFqghyPGDFiveYIGqtrgwfyTLHVL 593
Cdd:COG0495 475 ewvnvtcpkcggparretDTMDTFVDS-SwyyLRYTDPHNdeaPFdpEAANyWL----PVDQ---YIGgie--haILHLL 544
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489502821 594 -----ATALFDR-------PaFKTCVAHGIV--LGFDG------QKMSKSLRNYPDVTEVFDRDGSDAMRWFLM-ASPIL 652
Cdd:COG0495 545 yarffTKVLRDLglvsfdeP-FKRLLTQGMVleVGKDGvviggiEKMSKSKGNVVDPDEIIEKYGADTLRLFEMfAGPPE 623
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489502821 653 RGgnLIVTEQGIrDGVRQVLLPLWNT-YSFLALYAPKVGTWRVDSVHVldRYILAK-LAVLRDDL---------SESMEv 721
Cdd:COG0495 624 RD--LEWSDSGV-EGAYRFLNRVWRLvVDEAEALKLDVADLSEADKEL--RRALHKtIKKVTEDIerlrfntaiAALME- 697
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489502821 722 ydipgacehlrqFTEALTnwyvrrsrsRFWAEDADAIDTLHTVLEVTTRLAAPLLPLITEIIWRGLTRERSVHLTDWPAP 801
Cdd:COG0495 698 ------------LVNALY---------KAKDSGEADRAVLREALETLVLLLAPFAPHIAEELWERLGHEGSVADAPWPEA 756
|
.
gi 489502821 802 D 802
Cdd:COG0495 757 D 757
|
|
| PRK11893 |
PRK11893 |
methionyl-tRNA synthetase; Reviewed |
412-806 |
3.58e-13 |
|
methionyl-tRNA synthetase; Reviewed
Pssm-ID: 237012 [Multi-domain] Cd Length: 511 Bit Score: 73.38 E-value: 3.58e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489502821 412 PHCWRCRNPLIYRSVSSWFVRVTDFRDRMVELNQQITWY--PEHVKDG--QFGKwlQGARDWSISRNRY-WGTPIPvwks 486
Cdd:PRK11893 142 YRCPPTGAPVEWVEEESYFFRLSKYQDKLLELYEANPDFiqPASRRNEviSFVK--SGLKDLSISRTNFdWGIPVP---- 215
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489502821 487 DDPAypridvygsldelerdfgvrpanlHRPYideltrpnpddptgrstmrripdvldVWFD------SGSMpyaqvhyp 560
Cdd:PRK11893 216 GDPK------------------------HVIY--------------------------VWFDaltnylTALG-------- 237
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489502821 561 fenldwfqghYPGDFIVEYIGQTRGWFYTLHVLAtalFD--R------PAF---------KTCVAHGIVLgFDGQKMSKS 623
Cdd:PRK11893 238 ----------YPDDEELLAELFNKYWPADVHLIG---KDilRfhavywPAFlmaaglplpKRVFAHGFLT-LDGEKMSKS 303
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489502821 624 LRNYPDVTEVFDRDGSDAMRWFLM-ASPILRGGNLivTEQGIRDGVRQVLLPLW-----NTYSFLALYAPKVgTWRVDSV 697
Cdd:PRK11893 304 LGNVIDPFDLVDEYGVDAVRYFLLrEIPFGQDGDF--SREAFINRINADLANDLgnlaqRTLSMIAKNFDGK-VPEPGAL 380
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489502821 698 HVLDRYILAKLAVLRDDLSESMEVYDIPGACEHLRQFTEALtNWYVrrSRSRFWA---EDADAIDT-LHTVLEVTTRLA- 772
Cdd:PRK11893 381 TEADEALLEAAAALLERVRAAMDNLAFDKALEAILALVRAA-NKYI--DEQAPWSlakTDPERLATvLYTLLEVLRGIAv 457
|
410 420 430
....*....|....*....|....*....|....*...
gi 489502821 773 --APLLPLITEIIWR--GLTRERSVHLTDWPAPDLLPS 806
Cdd:PRK11893 458 llQPVMPELAAKILDqlGVEEDENRDFAALSWGRLAPG 495
|
|
| MetRS_core |
cd00814 |
catalytic core domain of methioninyl-tRNA synthetases; Methionine tRNA synthetase (MetRS) ... |
53-200 |
3.67e-13 |
|
catalytic core domain of methioninyl-tRNA synthetases; Methionine tRNA synthetase (MetRS) catalytic core domain. This class I enzyme aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. MetRS, which consists of the core domain and an anti-codon binding domain, functions as a monomer. However, in some species the anti-codon binding domain is followed by an EMAP domain. In this case, MetRS functions as a homodimer. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. As a result of a deletion event, MetRS has a significantly shorter core domain insertion than IleRS, ValRS, and LeuR. Consequently, the MetRS insertion lacks the editing function.
Pssm-ID: 173907 [Multi-domain] Cd Length: 319 Bit Score: 71.79 E-value: 3.67e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489502821 53 PFANGLPHYGHLLTGYVKDIVPRYRTMRGYKVerRF--GWDTHGLPAELEVErQLGITdksqieamgiaafndacrasVL 130
Cdd:cd00814 9 PYVNGVPHLGHLYGTVLADVFARYQRLRGYDV--LFvtGTDEHGTKIEQKAE-EEGVT--------------------PQ 65
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 489502821 131 RYTDEWQAYVTRQARWVDFDNDY--KTLDLAYMESVIWAFKQLWDKGLAYEGYRVLPYCWRDETPLSnhELR 200
Cdd:cd00814 66 ELCDKYHEIFKDLFKWLNISFDYfiRTTSPRHKEIVQEFFKKLYENGYIYEGEYEGLYCVSCERFLP--EWR 135
|
|
| LeuRS_core |
cd00812 |
catalytic core domain of leucyl-tRNA synthetases; Leucyl tRNA synthetase (LeuRS) catalytic ... |
429-651 |
2.63e-12 |
|
catalytic core domain of leucyl-tRNA synthetases; Leucyl tRNA synthetase (LeuRS) catalytic core domain. This class I enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. In Aquifex aeolicus, the gene encoding LeuRS is split in two, just before the KMSKS motif. Consequently, LeuRS is a heterodimer, which likely superimposes with the LeuRS monomer found in most other organisms. LeuRS has an insertion in the core domain, which is subject to both deletions and rearrangements and thus differs between prokaryotic LeuRS and archaeal/eukaryotic LeuRS. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids.
Pssm-ID: 173906 [Multi-domain] Cd Length: 314 Bit Score: 69.20 E-value: 2.63e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489502821 429 WFVRV--TDFRDRMVE-LNQQITWyPEHVKDGQfgkwlqgaRDW-SISRNRYWGTPIPvWK------SD---------DP 489
Cdd:cd00812 132 WFLKYseTEWKEKLLKdLEKLDGW-PEEVRAMQ--------ENWiGCSRQRYWGTPIP-WTdtmeslSDstwyyarytDA 201
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489502821 490 AYPRIDVYGSLDELERDFgvrpanlhrpyideltrpnpddptgrstmrripdvlDVWfdsgsmpyaqvhYPfenLDWFQG 569
Cdd:cd00812 202 HNLEQPYEGDLEFDREEF------------------------------------EYW------------YP---VDIYIG 230
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489502821 570 hypGdfiVEYIGqtrgwfytLHVL-----ATALFDRPA-----FKTCVAHGIVLGfDGQKMSKSLRNYPDVTEVFDRDGS 639
Cdd:cd00812 231 ---G---KEHAP--------NHLLysrfnHKALFDEGLvtdepPKGLIVQGMVLL-EGEKMSKSKGNVVTPDEAIKKYGA 295
|
250
....*....|...
gi 489502821 640 DAMRWFLM-ASPI 651
Cdd:cd00812 296 DAARLYILfAAPP 308
|
|
| tRNA-synt_1g |
pfam09334 |
tRNA synthetases class I (M); This family includes methionyl tRNA synthetases. |
53-201 |
4.27e-12 |
|
tRNA synthetases class I (M); This family includes methionyl tRNA synthetases.
Pssm-ID: 401322 [Multi-domain] Cd Length: 387 Bit Score: 69.24 E-value: 4.27e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489502821 53 PFANGLPHYGHLLTGYVKDIVPRYRTMRGYKVerRF--GWDTHGLPAELEVErQLGITdksqieamgiaafndacrasVL 130
Cdd:pfam09334 8 PYANGPPHLGHLYSYIPADIFARYLRLRGYDV--LFvcGTDEHGTPIELKAE-KEGIT--------------------PE 64
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 489502821 131 RYTDEWQAYVTRQARW--VDFDNDYKTLDLAYMESVIWAFKQLWDKGLAYEGYRVLPYCWRDETPLSNHELRM 201
Cdd:pfam09334 65 ELVDRYHEIHREDFKKfnISFDDYGRTTSERHHELVQEFFLKLYENGYIYEKEIEQFYCPSDERFLPDRYVEG 137
|
|
| LeuRS_core |
cd00812 |
catalytic core domain of leucyl-tRNA synthetases; Leucyl tRNA synthetase (LeuRS) catalytic ... |
53-188 |
3.07e-11 |
|
catalytic core domain of leucyl-tRNA synthetases; Leucyl tRNA synthetase (LeuRS) catalytic core domain. This class I enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. In Aquifex aeolicus, the gene encoding LeuRS is split in two, just before the KMSKS motif. Consequently, LeuRS is a heterodimer, which likely superimposes with the LeuRS monomer found in most other organisms. LeuRS has an insertion in the core domain, which is subject to both deletions and rearrangements and thus differs between prokaryotic LeuRS and archaeal/eukaryotic LeuRS. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids.
Pssm-ID: 173906 [Multi-domain] Cd Length: 314 Bit Score: 65.73 E-value: 3.07e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489502821 53 PFANGLPHYGHLLTgYVK-DIVPRYRTMRGYKVERRFGWDTHGLPAEleverqlGITDKSQIEAMGIAAFNdacrasvlr 131
Cdd:cd00812 9 PYPSGALHVGHVRT-YTIgDIIARYKRMQGYNVLFPMGFDAFGLPAE-------NAAIKIGRDPEDWTEYN--------- 71
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 489502821 132 yTDEWQAYVTRQARWVDFDNDYKTLDLAYMESVIWAFKQLWDKGLAYEG-----YRVLPYCW 188
Cdd:cd00812 72 -IKKMKEQLKRMGFSYDWRREFTTCDPEYYKFTQWLFLKLYEKGLAYKKeapvnWCKLLDQW 132
|
|
| MetG |
COG0143 |
Methionyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Methionyl-tRNA ... |
412-787 |
4.84e-11 |
|
Methionyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Methionyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 439913 [Multi-domain] Cd Length: 544 Bit Score: 66.68 E-value: 4.84e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489502821 412 PHCWRCRNPLIYRSVSSWFVRVTDFRDRMVElnqqitWYPEHvKDGQ---FGK---WL-QGARDWSISRNRYWGTPIPvw 484
Cdd:COG0143 169 PRSAISGAPPELREEEHYFFRLSKYQDRLLE------WIEEN-PDIQpevRNEvlsWLkEGLQDLSISRDFDWGIPVP-- 239
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489502821 485 ksDDPAYpridvygsldelerdfgvrpanlhrpyideltrpnpddptgrstmrripdVLDVWFD------SGSMPYAQVH 558
Cdd:COG0143 240 --GDPGK--------------------------------------------------VFYVWFDaligyiSATKGYADDR 267
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489502821 559 YPFENLD-WFQGhyPGDFIVEYIGQ--TRgwFYTLhvlataLFdrPAF---------KTCVAHGIVLgFDGQKMSKSLRN 626
Cdd:COG0143 268 GLPEDFEkYWPA--PDTELVHFIGKdiIR--FHAI------IW--PAMlmaaglplpKKVFAHGFLT-VEGEKMSKSRGN 334
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489502821 627 YPDVTEVFDRDGSDAMRWFLMA-SPILRGGNLivTEQGIR-----DgvrqvllpLWNTY--------SFLALY----APK 688
Cdd:COG0143 335 VIDPDDLLDRYGPDALRYYLLReVPFGQDGDF--SWEDFVarvnsD--------LANDLgnlasrtlSMIHKYfdgkVPE 404
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489502821 689 VGTWRVDsvhvlDRYILAKLAVLRDDLSESMEVYDIPGACEHLRQFTeALTNWYVrrSRSRFWA----EDADAIDT-LHT 763
Cdd:COG0143 405 PGELTEA-----DEELLAEAEAALEEVAEAMEAFEFRKALEEIMALA-RAANKYI--DETAPWKlakdEDPERLATvLYT 476
|
410 420
....*....|....*....|....*..
gi 489502821 764 VLEVTTRLA---APLLPLITEIIWRGL 787
Cdd:COG0143 477 LLEALRILAillKPFLPETAEKILEQL 503
|
|
| MetRS_core |
cd00814 |
catalytic core domain of methioninyl-tRNA synthetases; Methionine tRNA synthetase (MetRS) ... |
405-648 |
6.81e-11 |
|
catalytic core domain of methioninyl-tRNA synthetases; Methionine tRNA synthetase (MetRS) catalytic core domain. This class I enzyme aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. MetRS, which consists of the core domain and an anti-codon binding domain, functions as a monomer. However, in some species the anti-codon binding domain is followed by an EMAP domain. In this case, MetRS functions as a homodimer. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. As a result of a deletion event, MetRS has a significantly shorter core domain insertion than IleRS, ValRS, and LeuR. Consequently, the MetRS insertion lacks the editing function.
Pssm-ID: 173907 [Multi-domain] Cd Length: 319 Bit Score: 64.86 E-value: 6.81e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489502821 405 ETYEHPY-PHCwrCRNPLIYRSVSSWFVRVTDFRDRM---VELNQQITWyPEHVKDgQFGKWL-QGARDWSISR-NRYWG 478
Cdd:cd00814 117 GEYEGLYcVSC--ERFLPEWREEEHYFFRLSKFQDRLlewLEKNPDFIW-PENARN-EVLSWLkEGLKDLSITRdLFDWG 192
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489502821 479 TPIPvwksDDPAypridvygsldelerdfgvrpanlHRPYideltrpnpddptgrstmrripdvldVWFD------SGSM 552
Cdd:cd00814 193 IPVP----LDPG------------------------KVIY--------------------------VWFDaligyiSATG 218
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489502821 553 PYAQvhyPFENLDWFQGHYPGdfIVEYIGQTRGWFYTLH---VLATAlfDRPAFKTCVAHGIVLgFDGQKMSKSLRNYPD 629
Cdd:cd00814 219 YYNE---EWGNSWWWKDGWPE--LVHFIGKDIIRFHAIYwpaMLLGA--GLPLPTRIVAHGYLT-VEGKKMSKSRGNVVD 290
|
250
....*....|....*....
gi 489502821 630 VTEVFDRDGSDAMRWFLMA 648
Cdd:cd00814 291 PDDLLERYGADALRYYLLR 309
|
|
| tRNA-synt_1g |
pfam09334 |
tRNA synthetases class I (M); This family includes methionyl tRNA synthetases. |
412-649 |
3.54e-10 |
|
tRNA synthetases class I (M); This family includes methionyl tRNA synthetases.
Pssm-ID: 401322 [Multi-domain] Cd Length: 387 Bit Score: 63.08 E-value: 3.54e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489502821 412 PHCWRCRNPLIYRSVSSWFVRVTDFRDRMVElnqqitWYPEHVKDGQFG------KWL-QGARDWSISRNRYWGTPIPvw 484
Cdd:pfam09334 167 PKCVICGTTPEVKETEHYFFDLSKFQDKLRE------WIEENNPEWPENvknmvlEWLkEGLKDRAISRDLDWGIPVP-- 238
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489502821 485 ksddpaypridvygsldelerdfgvrpanlhrpyideltrPNPDdptgrstmrripDVLDVWFDSgSMPY-AQVHYPFEN 563
Cdd:pfam09334 239 ----------------------------------------GAEG------------KVFYVWLDA-PIGYiSATKELSGN 265
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489502821 564 LDWFQGHYPGDF---IVEYIGQTRGWFYTLH---VLATALFDRPafKTCVAHGIvLGFDGQKMSKSLRNYPDVTEVFDRD 637
Cdd:pfam09334 266 EEKWKEWWPNDPdteLVHFIGKDIIYFHTIFwpaMLLGAGYRLP--TTVFAHGY-LTYEGGKMSKSRGNVVWPSEALDRF 342
|
250
....*....|..
gi 489502821 638 GSDAMRWFLMAS 649
Cdd:pfam09334 343 PPDALRYYLARN 354
|
|
| MetG |
COG0143 |
Methionyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Methionyl-tRNA ... |
53-194 |
1.53e-08 |
|
Methionyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Methionyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 439913 [Multi-domain] Cd Length: 544 Bit Score: 58.59 E-value: 1.53e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489502821 53 PFANGLPHYGHLLTGYVKDIVPRYRTMRGYKVerRF--GWDTHGLPAELEVErQLGITDKsqieamgiaafndacrASVL 130
Cdd:COG0143 10 PYANGPPHIGHLYTYIPADILARYQRLRGHDV--LFvtGTDEHGTKIELAAE-KEGITPQ----------------ELVD 70
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 489502821 131 RYTDEWQAYvtrqarW----VDFDNDYKTLDLAYMESVIWAFKQLWDKGLAYEG-YRVLpYCWRDETPL 194
Cdd:COG0143 71 RIHAEFKEL------FeklgISFDNFIRTTSPEHKELVQEIFQRLYDNGDIYKGeYEGW-YCPECERFL 132
|
|
| Anticodon_Ia_like |
cd07375 |
Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; This ... |
667-776 |
5.78e-08 |
|
Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; This domain is found in a variety of class Ia aminoacyl tRNA synthetases, C-terminal to the catalytic core domain. It recognizes and specifically binds to the anticodon of the tRNA. Aminoacyl tRNA synthetases catalyze the transfer of cognate amino acids to the 3'-end of their tRNAs by specifically recognizing cognate from non-cognate amino acids. Members include valyl-, leucyl-, isoleucyl-, cysteinyl-, arginyl-, and methionyl-tRNA synthethases. This superfamily also includes a domain from MshC, an enzyme in the mycothiol biosynthetic pathway.
Pssm-ID: 153408 [Multi-domain] Cd Length: 117 Bit Score: 52.12 E-value: 5.78e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489502821 667 GVRQVLLPLWNTYSFLALYAPK-VGTWRVDSVHVLDRYILAKLAVLRDDLSESMEVYDIPGACEHLRQFTEALtNWYVRR 745
Cdd:cd07375 6 QARAFLNRLYRLLSFFRKALGGtQPKWDNELLEEADRELLARLQEFIKRTTNALEALDPTTAVQELFKFTNEL-NWYLDE 84
|
90 100 110
....*....|....*....|....*....|...
gi 489502821 746 SRSRFWAE--DADAIDTLHTVLEVTTRLAAPLL 776
Cdd:cd07375 85 LKPALQTEelREAVLAVLRAALVVLTKLLAPFT 117
|
|
| PRK11893 |
PRK11893 |
methionyl-tRNA synthetase; Reviewed |
52-203 |
6.01e-07 |
|
methionyl-tRNA synthetase; Reviewed
Pssm-ID: 237012 [Multi-domain] Cd Length: 511 Bit Score: 53.35 E-value: 6.01e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489502821 52 PPFANGLPHYGHLLTGYVKDIVPRYRTMRGYKVerRF--GWDTHGLpaelEVER---QLGITDKsqieamgiaafnDACR 126
Cdd:PRK11893 9 IYYPNGKPHIGHAYTTLAADVLARFKRLRGYDV--FFltGTDEHGQ----KIQRkaeEAGISPQ------------ELAD 70
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489502821 127 ASVLRYTDEWQAYvtrqarwvDFDNDY--KTLDLAYMESVIWAFKQLWDKGL----AYEGYrvlpYCWRDETPLSNHELR 200
Cdd:PRK11893 71 RNSAAFKRLWEAL--------NISYDDfiRTTDPRHKEAVQEIFQRLLANGDiylgKYEGW----YCVRCEEFYTESELI 138
|
...
gi 489502821 201 MDD 203
Cdd:PRK11893 139 EDG 141
|
|
| metG |
PRK00133 |
methionyl-tRNA synthetase; Reviewed |
53-114 |
3.05e-05 |
|
methionyl-tRNA synthetase; Reviewed
Pssm-ID: 234655 [Multi-domain] Cd Length: 673 Bit Score: 47.84 E-value: 3.05e-05
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 489502821 53 PFANGLPHYGHLLTgYVK-DIVPRYRTMRGYKVerRF--GWDTHGLPAELEVErQLGITDKSQIE 114
Cdd:PRK00133 11 PYANGPIHLGHLVE-YIQaDIWVRYQRMRGHEV--LFvcADDAHGTPIMLKAE-KEGITPEELIA 71
|
|
| PRK12267 |
PRK12267 |
methionyl-tRNA synthetase; Reviewed |
545-647 |
3.95e-05 |
|
methionyl-tRNA synthetase; Reviewed
Pssm-ID: 237028 [Multi-domain] Cd Length: 648 Bit Score: 47.49 E-value: 3.95e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489502821 545 VWFDS--------GsmpyaqvhYPFENLDWFQGHYPGDfiVEYIGQ--TRgwFYT------LHVLatalfDRPAFKTCVA 608
Cdd:PRK12267 227 VWIDAllnyitalG--------YGSDDDELFKKFWPAD--VHLVGKdiLR--FHAiywpimLMAL-----GLPLPKKVFA 289
|
90 100 110
....*....|....*....|....*....|....*....
gi 489502821 609 HGIVLgFDGQKMSKSLRNYPDVTEVFDRDGSDAMRWFLM 647
Cdd:PRK12267 290 HGWWL-MKDGKMSKSKGNVVDPEELVDRYGLDALRYYLL 327
|
|
| PRK12267 |
PRK12267 |
methionyl-tRNA synthetase; Reviewed |
56-192 |
5.33e-05 |
|
methionyl-tRNA synthetase; Reviewed
Pssm-ID: 237028 [Multi-domain] Cd Length: 648 Bit Score: 47.10 E-value: 5.33e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489502821 56 NGLPHYGHLLTGYVKDIVPRYRTMRGYKVerRF--GWDTHGLPAElEVERQLGITDKSqieamgiaafndacrasvlrYT 133
Cdd:PRK12267 16 NGKPHIGHAYTTIAADALARYKRLQGYDV--FFltGTDEHGQKIQ-QAAEKAGKTPQE--------------------YV 72
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 489502821 134 DEWQAYVtrQARWVDFD--NDY--KTLDLAYMESVIWAFKQLWDKG----LAYEGYrvlpYCWRDET 192
Cdd:PRK12267 73 DEISAGF--KELWKKLDisYDKfiRTTDERHKKVVQKIFEKLYEQGdiykGEYEGW----YCVSCET 133
|
|
| CysRS_core |
cd00672 |
catalytic core domain of cysteinyl tRNA synthetase; Cysteinyl tRNA synthetase (CysRS) ... |
594-649 |
8.25e-03 |
|
catalytic core domain of cysteinyl tRNA synthetase; Cysteinyl tRNA synthetase (CysRS) catalytic core domain. This class I enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding.
Pssm-ID: 173899 [Multi-domain] Cd Length: 213 Bit Score: 39.10 E-value: 8.25e-03
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*.
gi 489502821 594 ATALFDRPaFKTCVAHGIVLGFDGQKMSKSLRNYPDVTEVFDRDGSDAMRWFLMAS 649
Cdd:cd00672 150 SEAATGKP-FARYWLHTGHLTIDGEKMSKSLGNFITVRDALKKYDPEVLRLALLSS 204
|
|
| metG |
PRK00133 |
methionyl-tRNA synthetase; Reviewed |
412-484 |
8.40e-03 |
|
methionyl-tRNA synthetase; Reviewed
Pssm-ID: 234655 [Multi-domain] Cd Length: 673 Bit Score: 40.14 E-value: 8.40e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489502821 412 PHCWRCRNPLIYRSVSSWFVRVTDFRDRMVE-LNQQITWyPEHVKdGQFGKWL-QGARDWSISRN-RYWGTPIP------ 482
Cdd:PRK00133 170 PKSAISGATPVLKESEHFFFKLPRFEEFLKEwITRSGEL-QPNVA-NKMKEWLeEGLQDWDISRDaPYFGFEIPgapgkv 247
|
....
gi 489502821 483 --VW 484
Cdd:PRK00133 248 fyVW 251
|
|
| |
