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Conserved domains on  [gi|489462523|ref|WP_003367721|]
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MULTISPECIES: heme biosynthesis protein HemY [Pseudomonas]

Protein Classification

heme biosynthesis protein HemY( domain architecture ID 11489224)

heme biosynthesis protein HemY similar to Escherichia coli HemY, is found in heme biosynthesis gene clusters and contains tetratricopeptide repeats (TPRs)

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TPR_hemY_coli TIGR00540
heme biosynthesis-associated TPR protein; Members of this protein family are uncharacterized ...
 25-395 2.51e-96

heme biosynthesis-associated TPR protein; Members of this protein family are uncharacterized tetratricopeptide repeat (TPR) proteins invariably found in heme biosynthesis gene clusters. The absence of any invariant residues other than Ala argues against this protein serving as an enzyme per se. The gene symbol hemY assigned in E. coli is unfortunate in that an unrelated protein, protoporphyrinogen oxidase (HemG in E. coli) is designated HemY in Bacillus subtilis. [Unknown function, General]


:

Pssm-ID: 273126 [Multi-domain]  Cd Length: 367  Bit Score: 292.66  E-value: 2.51e-96
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489462523   25 HSGYVLIAYQNFRYESSLWATLALLVAALLVIALLRLLISLLTTSGRVVNPWSRRNRRRRVQMAIEQGQMDLAEGRWSSA 104
Cdd:TIGR00540   5 NTGYVLIVYPPYRIELSLNFFVLLLVLLFVVLYILLRLIRRVFRLPRRVRAWRSRRKQRRAQQATREGLIALFEGRYSQA 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489462523  105 QRHLQRAAEADTHPLLYYIGAARAANEQGRYEDCDALLERALERQPQAELAIALNHAQLQQDRGDTEGALTTLLAMKERH 184
Cdd:TIGR00540  85 EKKATKAAEHSENPLLAYLLAARAAQQMGDEERRDRYLAEAAELAPNSELAVLLTRAELLLDQRDYEAALAALDSLQAQA 164

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489462523  185 PHNPQVLRQLQRLYQQRGDWSDVVRLMPELRKDKVLPAKELAELERRAWGENLSLAAyREGIEGaptglpsLESAWQGLA 264
Cdd:TIGR00540 165 PRHTAVLRLALRAYQRSGNWDALLKLLPALRKAKALSPEEAARLEQQAYIGLLDEAR-EEDADA-------LKTWWKQLP 236

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489462523  265 SAQRQEPQLVLAYADQLRRLGAEAQAEEVLRSALKREYNSHLARLYGLVRGSDPLKQLQTAEGWLKHHPADPSLLLSLGR 344
Cdd:TIGR00540 237 RAERQEPELAVAAAEALIQLGDHDEAEKLIEEALKKEWDPELLRLYGRLQPGDPSPLIKRAEKWLKKHPDDALLLLALGR 316

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|.
gi 489462523  345 ICLQGRLWGKARDYLESSLRLERNPETCAELARLLGQLGETDRSNQLFQEG 395
Cdd:TIGR00540 317 LCLRQQLWGKAQSYLEASLSLAPTEEAHLELAQLFEQLGDTEAAAQHYRKS 367
 
Name Accession Description Interval E-value
TPR_hemY_coli TIGR00540
heme biosynthesis-associated TPR protein; Members of this protein family are uncharacterized ...
 25-395 2.51e-96

heme biosynthesis-associated TPR protein; Members of this protein family are uncharacterized tetratricopeptide repeat (TPR) proteins invariably found in heme biosynthesis gene clusters. The absence of any invariant residues other than Ala argues against this protein serving as an enzyme per se. The gene symbol hemY assigned in E. coli is unfortunate in that an unrelated protein, protoporphyrinogen oxidase (HemG in E. coli) is designated HemY in Bacillus subtilis. [Unknown function, General]


Pssm-ID: 273126 [Multi-domain]  Cd Length: 367  Bit Score: 292.66  E-value: 2.51e-96
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489462523   25 HSGYVLIAYQNFRYESSLWATLALLVAALLVIALLRLLISLLTTSGRVVNPWSRRNRRRRVQMAIEQGQMDLAEGRWSSA 104
Cdd:TIGR00540   5 NTGYVLIVYPPYRIELSLNFFVLLLVLLFVVLYILLRLIRRVFRLPRRVRAWRSRRKQRRAQQATREGLIALFEGRYSQA 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489462523  105 QRHLQRAAEADTHPLLYYIGAARAANEQGRYEDCDALLERALERQPQAELAIALNHAQLQQDRGDTEGALTTLLAMKERH 184
Cdd:TIGR00540  85 EKKATKAAEHSENPLLAYLLAARAAQQMGDEERRDRYLAEAAELAPNSELAVLLTRAELLLDQRDYEAALAALDSLQAQA 164

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489462523  185 PHNPQVLRQLQRLYQQRGDWSDVVRLMPELRKDKVLPAKELAELERRAWGENLSLAAyREGIEGaptglpsLESAWQGLA 264
Cdd:TIGR00540 165 PRHTAVLRLALRAYQRSGNWDALLKLLPALRKAKALSPEEAARLEQQAYIGLLDEAR-EEDADA-------LKTWWKQLP 236

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489462523  265 SAQRQEPQLVLAYADQLRRLGAEAQAEEVLRSALKREYNSHLARLYGLVRGSDPLKQLQTAEGWLKHHPADPSLLLSLGR 344
Cdd:TIGR00540 237 RAERQEPELAVAAAEALIQLGDHDEAEKLIEEALKKEWDPELLRLYGRLQPGDPSPLIKRAEKWLKKHPDDALLLLALGR 316

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|.
gi 489462523  345 ICLQGRLWGKARDYLESSLRLERNPETCAELARLLGQLGETDRSNQLFQEG 395
Cdd:TIGR00540 317 LCLRQQLWGKAQSYLEASLSLAPTEEAHLELAQLFEQLGDTEAAAQHYRKS 367
HemYx COG3071
Uncharacterized protein HemY, contains HemY_N domain and TPR repeats (unrelated to ...
 88-401 3.84e-90

Uncharacterized protein HemY, contains HemY_N domain and TPR repeats (unrelated to protoporphyrinogen oxidase HemY) [Function unknown];


Pssm-ID: 442305 [Multi-domain]  Cd Length: 323  Bit Score: 275.25  E-value: 3.84e-90
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489462523  88 AIEQGQMDLAEGRWSSAQRHLQRAAEADTHPLLYYIGAARAANEQGRYEDCDALLERALERQPQAELAIALNHAQLQQDR 167
Cdd:COG3071   19 ALLEGLLALAEGRYARAEKLLSKAAEHSEAPLLAYLLAARAAQALGDYERRDEYLAQALELAPEAELAVLLTRAELLLDQ 98

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489462523 168 GDTEGALTTLLAMKERHPHNPQVLRQLQRLYQQRGDWSDVVRLMPELRKDKVLPAKELAELERRAWGENLSLAAyregie 247
Cdd:COG3071   99 GQAEQALATLEALRAGAPRHPQVLRLLLQAYRQLGDWEELLELLPALRKHKALSAEEAQALERRAYLGLLRQAA------ 172

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489462523 248 gapTGLPSLESAWQGLASAQRQEPQLVLAYADQLRRLGAEAQAEEVLRSALKREYNSHLARLYGLVRGSDPLKQLQTAEG 327
Cdd:COG3071  173 ---RDAEALKALWKALPRAERRDPELAAAYARALIALGDHDEAERLLREALKRQWDPRLVRLYGRLQGGDPAKQLKRAEK 249

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 489462523 328 WLKHHPADPSLLLSLGRICLQGRLWGKARDYLESSLRLERNPETCAELARLLGQLGETDRSNQLFQEGLGLLDE 401
Cdd:COG3071  250 WLKKHPNDPDLLLALGRLCLRNQLWGKAREYLEAALALRPSAEAYAELARLLEQLGDPEEAAEHYRKALALALG 323
PRK10747 PRK10747
putative protoheme IX biogenesis protein; Provisional
 25-398 3.24e-21

putative protoheme IX biogenesis protein; Provisional


Pssm-ID: 182695 [Multi-domain]  Cd Length: 398  Bit Score: 94.77  E-value: 3.24e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489462523  25 HSGYVLIAYQNFRYESSLWATLALLVAALLVIALLRLLISLLTTSGRVVNPWSRRNRRRRVQMAIEQGQMDLAEGRWSSA 104
Cdd:PRK10747  24 HQGYVLIQTDNYNIETSVTGLAIILILAMVVLFAIEWLLRRIFRTGARTRGWFVGRKRRRARKQTEQALLKLAEGDYQQV 103

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489462523 105 QRHLQRAAEADTHPLLYYIGAARAANEQGRYEDCDALLERALERQPQAELAIALNHAQLQQDRGDTEGALTTLLAMKERH 184
Cdd:PRK10747 104 EKLMTRNADHAEQPVVNYLLAAEAAQQRGDEARANQHLERAAELADNDQLPVEITRVRIQLARNENHAARHGVDKLLEVA 183

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489462523 185 PHNPQVLRQLQRLYQQRGDWSDVVRLMPELRKDKVLPAKELAELERRAWGENLSLAAYREGIEGaptglpsLESAWQGLA 264
Cdd:PRK10747 184 PRHPEVLRLAEQAYIRTGAWSSLLDILPSMAKAHVGDEEHRAMLEQQAWIGLMDQAMADQGSEG-------LKRWWKNQS 256

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489462523 265 SAQRQEPQLVLAYADQLRRLGAEAQAEEVLRSALKREYNSHLARLYGLVRGSDPLKQLQTAEGWLKHHPADPSLLLSLGR 344
Cdd:PRK10747 257 RKTRHQVALQVAMAEHLIECDDHDTAQQIILDGLKRQYDERLVLLIPRLKTNNPEQLEKVLRQQIKQHGDTPLLWSTLGQ 336

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|....
gi 489462523 345 ICLQGRLWGKARDYLESSLRLERNPETCAELARLLGQLGETDRSNQLFQEGLGL 398
Cdd:PRK10747 337 LLMKHGEWQEASLAFRAALKQRPDAYDYAWLADALDRLHKPEEAAAMRRDGLML 390
HemY_N pfam07219
HemY protein N-terminus; This family represents the N-terminus (approximately 150 residues) of ...
 68-133 5.93e-11

HemY protein N-terminus; This family represents the N-terminus (approximately 150 residues) of bacterial HemY porphyrin biosynthesis proteins. This is a membrane protein involved in a late step of protoheme IX synthesis.


Pssm-ID: 429353 [Multi-domain]  Cd Length: 104  Bit Score: 59.06  E-value: 5.93e-11
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 489462523   68 TSGRVVNPWSRRNRRRRVQMAIEQGQMDLAEGRWSSAQRHLQRAAEADTHPLLYYIGAARAANEQG 133
Cdd:pfam07219  39 RLPGRVRRWRRRRRRRKARKALSEGLIALAEGDWAQAEKLAAKAAKLLDAPLLNYLLAARAAQLQG 104
 
Name Accession Description Interval E-value
TPR_hemY_coli TIGR00540
heme biosynthesis-associated TPR protein; Members of this protein family are uncharacterized ...
 25-395 2.51e-96

heme biosynthesis-associated TPR protein; Members of this protein family are uncharacterized tetratricopeptide repeat (TPR) proteins invariably found in heme biosynthesis gene clusters. The absence of any invariant residues other than Ala argues against this protein serving as an enzyme per se. The gene symbol hemY assigned in E. coli is unfortunate in that an unrelated protein, protoporphyrinogen oxidase (HemG in E. coli) is designated HemY in Bacillus subtilis. [Unknown function, General]


Pssm-ID: 273126 [Multi-domain]  Cd Length: 367  Bit Score: 292.66  E-value: 2.51e-96
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489462523   25 HSGYVLIAYQNFRYESSLWATLALLVAALLVIALLRLLISLLTTSGRVVNPWSRRNRRRRVQMAIEQGQMDLAEGRWSSA 104
Cdd:TIGR00540   5 NTGYVLIVYPPYRIELSLNFFVLLLVLLFVVLYILLRLIRRVFRLPRRVRAWRSRRKQRRAQQATREGLIALFEGRYSQA 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489462523  105 QRHLQRAAEADTHPLLYYIGAARAANEQGRYEDCDALLERALERQPQAELAIALNHAQLQQDRGDTEGALTTLLAMKERH 184
Cdd:TIGR00540  85 EKKATKAAEHSENPLLAYLLAARAAQQMGDEERRDRYLAEAAELAPNSELAVLLTRAELLLDQRDYEAALAALDSLQAQA 164

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489462523  185 PHNPQVLRQLQRLYQQRGDWSDVVRLMPELRKDKVLPAKELAELERRAWGENLSLAAyREGIEGaptglpsLESAWQGLA 264
Cdd:TIGR00540 165 PRHTAVLRLALRAYQRSGNWDALLKLLPALRKAKALSPEEAARLEQQAYIGLLDEAR-EEDADA-------LKTWWKQLP 236

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489462523  265 SAQRQEPQLVLAYADQLRRLGAEAQAEEVLRSALKREYNSHLARLYGLVRGSDPLKQLQTAEGWLKHHPADPSLLLSLGR 344
Cdd:TIGR00540 237 RAERQEPELAVAAAEALIQLGDHDEAEKLIEEALKKEWDPELLRLYGRLQPGDPSPLIKRAEKWLKKHPDDALLLLALGR 316

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|.
gi 489462523  345 ICLQGRLWGKARDYLESSLRLERNPETCAELARLLGQLGETDRSNQLFQEG 395
Cdd:TIGR00540 317 LCLRQQLWGKAQSYLEASLSLAPTEEAHLELAQLFEQLGDTEAAAQHYRKS 367
HemYx COG3071
Uncharacterized protein HemY, contains HemY_N domain and TPR repeats (unrelated to ...
 88-401 3.84e-90

Uncharacterized protein HemY, contains HemY_N domain and TPR repeats (unrelated to protoporphyrinogen oxidase HemY) [Function unknown];


Pssm-ID: 442305 [Multi-domain]  Cd Length: 323  Bit Score: 275.25  E-value: 3.84e-90
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489462523  88 AIEQGQMDLAEGRWSSAQRHLQRAAEADTHPLLYYIGAARAANEQGRYEDCDALLERALERQPQAELAIALNHAQLQQDR 167
Cdd:COG3071   19 ALLEGLLALAEGRYARAEKLLSKAAEHSEAPLLAYLLAARAAQALGDYERRDEYLAQALELAPEAELAVLLTRAELLLDQ 98

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489462523 168 GDTEGALTTLLAMKERHPHNPQVLRQLQRLYQQRGDWSDVVRLMPELRKDKVLPAKELAELERRAWGENLSLAAyregie 247
Cdd:COG3071   99 GQAEQALATLEALRAGAPRHPQVLRLLLQAYRQLGDWEELLELLPALRKHKALSAEEAQALERRAYLGLLRQAA------ 172

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489462523 248 gapTGLPSLESAWQGLASAQRQEPQLVLAYADQLRRLGAEAQAEEVLRSALKREYNSHLARLYGLVRGSDPLKQLQTAEG 327
Cdd:COG3071  173 ---RDAEALKALWKALPRAERRDPELAAAYARALIALGDHDEAERLLREALKRQWDPRLVRLYGRLQGGDPAKQLKRAEK 249

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 489462523 328 WLKHHPADPSLLLSLGRICLQGRLWGKARDYLESSLRLERNPETCAELARLLGQLGETDRSNQLFQEGLGLLDE 401
Cdd:COG3071  250 WLKKHPNDPDLLLALGRLCLRNQLWGKAREYLEAALALRPSAEAYAELARLLEQLGDPEEAAEHYRKALALALG 323
PRK10747 PRK10747
putative protoheme IX biogenesis protein; Provisional
 25-398 3.24e-21

putative protoheme IX biogenesis protein; Provisional


Pssm-ID: 182695 [Multi-domain]  Cd Length: 398  Bit Score: 94.77  E-value: 3.24e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489462523  25 HSGYVLIAYQNFRYESSLWATLALLVAALLVIALLRLLISLLTTSGRVVNPWSRRNRRRRVQMAIEQGQMDLAEGRWSSA 104
Cdd:PRK10747  24 HQGYVLIQTDNYNIETSVTGLAIILILAMVVLFAIEWLLRRIFRTGARTRGWFVGRKRRRARKQTEQALLKLAEGDYQQV 103

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489462523 105 QRHLQRAAEADTHPLLYYIGAARAANEQGRYEDCDALLERALERQPQAELAIALNHAQLQQDRGDTEGALTTLLAMKERH 184
Cdd:PRK10747 104 EKLMTRNADHAEQPVVNYLLAAEAAQQRGDEARANQHLERAAELADNDQLPVEITRVRIQLARNENHAARHGVDKLLEVA 183

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489462523 185 PHNPQVLRQLQRLYQQRGDWSDVVRLMPELRKDKVLPAKELAELERRAWGENLSLAAYREGIEGaptglpsLESAWQGLA 264
Cdd:PRK10747 184 PRHPEVLRLAEQAYIRTGAWSSLLDILPSMAKAHVGDEEHRAMLEQQAWIGLMDQAMADQGSEG-------LKRWWKNQS 256

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489462523 265 SAQRQEPQLVLAYADQLRRLGAEAQAEEVLRSALKREYNSHLARLYGLVRGSDPLKQLQTAEGWLKHHPADPSLLLSLGR 344
Cdd:PRK10747 257 RKTRHQVALQVAMAEHLIECDDHDTAQQIILDGLKRQYDERLVLLIPRLKTNNPEQLEKVLRQQIKQHGDTPLLWSTLGQ 336

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|....
gi 489462523 345 ICLQGRLWGKARDYLESSLRLERNPETCAELARLLGQLGETDRSNQLFQEGLGL 398
Cdd:PRK10747 337 LLMKHGEWQEASLAFRAALKQRPDAYDYAWLADALDRLHKPEEAAAMRRDGLML 390
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 89-364 1.99e-12

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 67.06  E-value: 1.99e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489462523  89 IEQGQMDLAEGRWSSAQRHLQRAAEADTHPLLYYIGAARAANEQGRYEDCDALLERALERQPQAELAIaLNHAQLQQDRG 168
Cdd:COG2956   12 YFKGLNYLLNGQPDKAIDLLEEALELDPETVEAHLALGNLYRRRGEYDRAIRIHQKLLERDPDRAEAL-LELAQDYLKAG 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489462523 169 DTEGALTTLLAMKERHPHNPQVLRQLQRLYQQRGDWS---DVVRLMPELRKDKVLPAKELAELERRAWGENLSLAAYREG 245
Cdd:COG2956   91 LLDRAEELLEKLLELDPDDAEALRLLAEIYEQEGDWEkaiEVLERLLKLGPENAHAYCELAELYLEQGDYDEAIEALEKA 170

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489462523 246 IEGAPTGLPSLesawqglasaqrqepqlvLAYADQLRRLGAEAQAEEVLRSALKR--EYNSHLARLYGLVRG-SDPLKQL 322
Cdd:COG2956  171 LKLDPDCARAL------------------LLLAELYLEQGDYEEAIAALERALEQdpDYLPALPRLAELYEKlGDPEEAL 232

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|..
gi 489462523 323 QTAEGWLKHHPaDPSLLLSLGRICLQGRLWGKARDYLESSLR 364
Cdd:COG2956  233 ELLRKALELDP-SDDLLLALADLLERKEGLEAALALLERQLR 273
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 88-382 3.55e-12

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 68.19  E-value: 3.55e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489462523   88 AIEQGQMDLAEGRWSSAQRHLQRAAEADTHPLLYYIGAARAANEQGRYEDCDALLERALERQPQA-ELAIALNHAQLQQd 166
Cdd:TIGR02917 502 AANLARIDIQEGNPDDAIQRFEKVLTIDPKNLRAILALAGLYLRTGNEEEAVAWLEKAAELNPQEiEPALALAQYYLGK- 580

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489462523  167 rGDTEGALTTLLAMKERHPHNPQVLRQLQRLYQQRGDWSDVVRLMPELRK---DKVLPAKELAELERRAWGENLSLAAYR 243
Cdd:TIGR02917 581 -GQLKKALAILNEAADAAPDSPEAWLMLGRAQLAAGDLNKAVSSFKKLLAlqpDSALALLLLADAYAVMKNYAKAITSLK 659

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489462523  244 EGIEGAP------TGLPSL-------ESAWQGLASAQRQEPQLVLAYAdQLRRLGAE----AQAEEVLRSALKREYNSHL 306
Cdd:TIGR02917 660 RALELKPdnteaqIGLAQLllaakrtESAKKIAKSLQKQHPKAALGFE-LEGDLYLRqkdyPAAIQAYRKALKRAPSSQN 738

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 489462523  307 ARLYG--LVRGSDPLKQLQTAEGWLKHHPADPSLLLSLGRICLQGRLWGKARDYLESSLRLE-RNPETCAELARLLGQL 382
Cdd:TIGR02917 739 AIKLHraLLASGNTAEAVKTLEAWLKTHPNDAVLRTALAELYLAQKDYDKAIKHYQTVVKKApDNAVVLNNLAWLYLEL 817
HemY_N pfam07219
HemY protein N-terminus; This family represents the N-terminus (approximately 150 residues) of ...
 68-133 5.93e-11

HemY protein N-terminus; This family represents the N-terminus (approximately 150 residues) of bacterial HemY porphyrin biosynthesis proteins. This is a membrane protein involved in a late step of protoheme IX synthesis.


Pssm-ID: 429353 [Multi-domain]  Cd Length: 104  Bit Score: 59.06  E-value: 5.93e-11
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 489462523   68 TSGRVVNPWSRRNRRRRVQMAIEQGQMDLAEGRWSSAQRHLQRAAEADTHPLLYYIGAARAANEQG 133
Cdd:pfam07219  39 RLPGRVRRWRRRRRRRKARKALSEGLIALAEGDWAQAEKLAAKAAKLLDAPLLNYLLAARAAQLQG 104
HemYx COG3898
Uncharacterized protein HemY, contains HemY_N domain and TPR repeats (unrelated to HemY-type ...
 84-378 9.67e-11

Uncharacterized protein HemY, contains HemY_N domain and TPR repeats (unrelated to HemY-type protoporphyrinogen oxidase) [Function unknown];


Pssm-ID: 443105 [Multi-domain]  Cd Length: 468  Bit Score: 63.37  E-value: 9.67e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489462523  84 RVQMAIEQGQMDLAEGRWSSAQRHLQRAAEADTHPLLYYIGAARAANEQGRYEDCDALLERALERQPQAELAI-ALnhAQ 162
Cdd:COG3898   83 KGYQALSRGLIAVAAGDGRLARRKAAKAERLLDRPPLTLLLEAQAAQLAGDREAARRAFEAMLEDPETRFLGLrGL--MV 160

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489462523 163 LQQDRGDTEGALTtlLAMK--ERHPHNPQVLRQLQRLYQQRGDWSDVVRLMPELRKDKVLPAKELAelERRAwgeNLSLA 240
Cdd:COG3898  161 EALRRGDTEAALA--LAEEalALAPKLPWAQDALLELQAAAGDWDGALATLDAALKAGLLDKDVAR--RRRA---VLLTA 233

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489462523 241 AYREGIEGAPTGlpSLESAwqglASAQRQEPQLV---LAYADQLRRLGAEAQAEEVLRSALKREYNSHLARLYG-LVRGS 316
Cdd:COG3898  234 RARELEEGDPDE--ARELA----IEALKLAPDLVpaaVLAARLLIAQGKLRKAAKVLEKAWRAQPHPDLAAAYAeLRPGD 307

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 489462523 317 DPLKQLQTAEGWLKHHPADPSLLLSLGRICLQGRLWGKARDYLESSLRLERNPETCAELARL 378
Cdd:COG3898  308 SALDRLKRAETLAALNPDHPESRLALAEAALAAGDFGEARRALGPLLEERPTARVCLLMAEI 369
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 96-206 4.32e-09

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 58.47  E-value: 4.32e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489462523  96 LAEGRWSSAQRHLQRAAEADTHPLLYYIGAARAANEQGRYEDCDALLERALERQPqAELAIALNHAQLQQDRGDTEGALT 175
Cdd:COG3914   89 QALGRYEEALALYRRALALNPDNAEALFNLGNLLLALGRLEEALAALRRALALNP-DFAEAYLNLGEALRRLGRLEEAIA 167

                         90       100       110
                 ....*....|....*....|....*....|.
gi 489462523 176 TLLAMKERHPHNPQVLRQLQRLYQQRGDWSD 206
Cdd:COG3914  168 ALRRALELDPDNAEALNNLGNALQDLGRLEE 198
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 108-397 4.70e-09

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 58.56  E-value: 4.70e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489462523  108 LQRAAEADTHPLLYYIGAARAANEQGRYEDCDALLERALERQPQAELAIALNhAQLQQDRGDTEGALTTLLAMKERHPHN 187
Cdd:TIGR02917 590 LNEAADAAPDSPEAWLMLGRAQLAAGDLNKAVSSFKKLLALQPDSALALLLL-ADAYAVMKNYAKAITSLKRALELKPDN 668

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489462523  188 PQVLRQLQRLYQQRGDWSDVVRLMPELRKDKVLPAKELAELERRAWGEN---LSLAAYREGIEGAPTglpslESAWQGLA 264
Cdd:TIGR02917 669 TEAQIGLAQLLLAAKRTESAKKIAKSLQKQHPKAALGFELEGDLYLRQKdypAAIQAYRKALKRAPS-----SQNAIKLH 743

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489462523  265 SAQRQ---EPQLVLAYADQLRR-----------------LGAEAQAEEVLRSALKREYN-----SHLARLYGlvRGSDPl 319
Cdd:TIGR02917 744 RALLAsgnTAEAVKTLEAWLKThpndavlrtalaelylaQKDYDKAIKHYQTVVKKAPDnavvlNNLAWLYL--ELKDP- 820

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 489462523  320 KQLQTAEGWLKHHPADPSLLLSLGRICLQGRLWGKARDYLESSLRL-ERNPETCAELARLLGQLGETDRSNQLFQEGLG 397
Cdd:TIGR02917 821 RALEYAERALKLAPNIPAILDTLGWLLVEKGEADRALPLLRKAVNIaPEAAAIRYHLALALLATGRKAEARKELDKLLN 899
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 88-385 5.36e-09

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 58.17  E-value: 5.36e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489462523   88 AIEQGQMDLAegrwSSAQRHLQraAEADTHPLLYYIGAARAANEqGRYEDCDALLERALERQPQAELAIAlNHAQLQQDR 167
Cdd:TIGR02917 441 YLRSGQFDKA----LAAAKKLE--KKQPDNASLHNLLGAIYLGK-GDLAKAREAFEKALSIEPDFFPAAA-NLARIDIQE 512

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489462523  168 GDTEGALTTLLAMKERHPHNPQVLRQLQRLYQQRGDWSDVVRLM---PELRKDKVLPAKELAELERRAWGENLSLAAYRE 244
Cdd:TIGR02917 513 GNPDDAIQRFEKVLTIDPKNLRAILALAGLYLRTGNEEEAVAWLekaAELNPQEIEPALALAQYYLGKGQLKKALAILNE 592

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489462523  245 GIEGAPTGLpsleSAWQGLASAQRQ----------------------EPQLVLAYADQLRRlgAEAQAEEVLRSALKREY 302
Cdd:TIGR02917 593 AADAAPDSP----EAWLMLGRAQLAagdlnkavssfkkllalqpdsaLALLLLADAYAVMK--NYAKAITSLKRALELKP 666

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489462523  303 NSHLARLYG---LVRGSDPLKQLQTAEGWLKHHPADPSLLLSLGRICLQGRLWGKARDYLESSLRLERNPETCAELARLL 379
Cdd:TIGR02917 667 DNTEAQIGLaqlLLAAKRTESAKKIAKSLQKQHPKAALGFELEGDLYLRQKDYPAAIQAYRKALKRAPSSQNAIKLHRAL 746


                  ....*.
gi 489462523  380 GQLGET 385
Cdd:TIGR02917 747 LASGNT 752
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 89-301 5.49e-09

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 56.66  E-value: 5.49e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489462523  89 IEQGQMDLAEGRWSSAQRHLQRAAEADTHPLLYYIGAARAANEQGRYEDCDALLERALERQPQAELAiALNHAQLQQDRG 168
Cdd:COG2956   80 LELAQDYLKAGLLDRAEELLEKLLELDPDDAEALRLLAEIYEQEGDWEKAIEVLERLLKLGPENAHA-YCELAELYLEQG 158

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489462523 169 DTEGALTTLLAMKERHPHNPQVLRQLQRLYQQRGDWSDVVRLMpelrkdkvlpaKELAELERRAWGENLSLAAYREGIEG 248
Cdd:COG2956  159 DYDEAIEALEKALKLDPDCARALLLLAELYLEQGDYEEAIAAL-----------ERALEQDPDYLPALPRLAELYEKLGD 227

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|...
gi 489462523 249 APTGLPSLESAWQglasaQRQEPQLVLAYADQLRRLGAEAQAEEVLRSALKRE 301
Cdd:COG2956  228 PEEALELLRKALE-----LDPSDDLLLALADLLERKEGLEAALALLERQLRRH 275
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 89-204 6.13e-09

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 54.04  E-value: 6.13e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489462523  89 IEQGQMDLAEGRWSSAQRHLQRAAEADTHPLLYYIGAARAANEQGRYEDCDALLERALERQPQaELAIALNHAQLQQDRG 168
Cdd:COG4783    8 YALAQALLLAGDYDEAEALLEKALELDPDNPEAFALLGEILLQLGDLDEAIVLLHEALELDPD-EPEARLNLGLALLKAG 86

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 489462523 169 DTEGALTTLLAMKERHPHNPQVLRQLQRLYQQRGDW 204
Cdd:COG4783   87 DYDEALALLEKALKLDPEHPEAYLRLARAYRALGRP 122
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 91-396 7.74e-09

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 57.79  E-value: 7.74e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489462523   91 QGQMDLAEGRWSSAQRHLQRAAEADTHPLLYYIGAARAANEQGRYEDCDALLERALERQPQAELAIALNhAQLQQDRGDT 170
Cdd:TIGR02917 199 KGDLLLSLGNIELALAAYRKAIALRPNNIAVLLALATILIEAGEFEEAEKHADALLKKAPNSPLAHYLK-ALVDFQKKNY 277

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489462523  171 EGALTTLLAMKERHPHNPQ-------VLRQLQRLYQQRGDWSDVVRLMPELRKDKVL----------PAKELAELERrAW 233
Cdd:TIGR02917 278 EDARETLQDALKSAPEYLPalllagaSEYQLGNLEQAYQYLNQILKYAPNSHQARRLlasiqlrlgrVDEAIATLSP-AL 356

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489462523  234 GENLSLAAYREGIEGAPTGLPSLESAWQGLASAQRQEPQLVLAYADQ-LRRL--GAEAQAEEVLRSALKREY---NSHLA 307
Cdd:TIGR02917 357 GLDPDDPAALSLLGEAYLALGDFEKAAEYLAKATELDPENAAARTQLgISKLsqGDPSEAIADLETAAQLDPelgRADLL 436

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489462523  308 RLYGLVRGSDPLKQLQTAEGWLKHHPADPSLLLSLGRICLQGRLWGKARDYLESSLRLER-NPETCAELARLLGQLGETD 386
Cdd:TIGR02917 437 LILSYLRSGQFDKALAAAKKLEKKQPDNASLHNLLGAIYLGKGDLAKAREAFEKALSIEPdFFPAAANLARIDIQEGNPD 516

                         330
                  ....*....|
gi 489462523  387 RSNQLFQEGL 396
Cdd:TIGR02917 517 DAIQRFEKVL 526
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 85-211 1.09e-07

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 52.81  E-value: 1.09e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489462523  85 VQMAIEQGQMDLAEGRWSSAQRHLQRAAEADTHPLLYYIGAARAANEQGRYEDCDALLERALERQPQAeLAIALNHAQLQ 164
Cdd:COG2956  144 AHAYCELAELYLEQGDYDEAIEALEKALKLDPDCARALLLLAELYLEQGDYEEAIAALERALEQDPDY-LPALPRLAELY 222

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 489462523 165 QDRGDTEGALTTLLAMKERHPHNPQVLRqLQRLYQQRGDWSDVVRLM 211
Cdd:COG2956  223 EKLGDPEEALELLRKALELDPSDDLLLA-LADLLERKEGLEAALALL 268
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 86-337 9.01e-07

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 51.15  E-value: 9.01e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489462523  86 QMAIEQGQMDLAEGRWSSAQRHLQRAAEADTHPLLYYI--GAARAANEQGRYEDCDALLERALERQPqAELAIALNHAQL 163
Cdd:COG3914   43 LALLLLAALAEAAAAALLALAAGEAAAAAAALLLLAALleLAALLLQALGRYEEALALYRRALALNP-DNAEALFNLGNL 121

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489462523 164 QQDRGDTEGALTTLLAMKERHPHNPQVLRQLQRLYQQRGDWSDvvrlmpelrkdkvlpakelaelerrawgenlSLAAYR 243
Cdd:COG3914  122 LLALGRLEEALAALRRALALNPDFAEAYLNLGEALRRLGRLEE-------------------------------AIAALR 170

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489462523 244 EGIEGAPTglpsLESAWQGLASAqrqepqlvlayadqLRRLGAEAQAEEVLRSALKR-----EYNSHLARLYGLVRGSDP 318
Cdd:COG3914  171 RALELDPD----NAEALNNLGNA--------------LQDLGRLEEAIAAYRRALELdpdnaDAHSNLLFALRQACDWEV 232

                        250
                 ....*....|....*....
gi 489462523 319 LKQLQTAEGWLKHHPADPS 337
Cdd:COG3914  233 YDRFEELLAALARGPSELS 251
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
92-303 3.27e-06

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 48.08  E-value: 3.27e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489462523  92 GQMDLAEGRWSSAQRHLQRAAEADTHPLLYYIGAARAANEQGRYEDCDALLERALERQPqaELAIALNH-AQLQQDRGDT 170
Cdd:COG0457   15 GLAYRRLGRYEEAIEDYEKALELDPDDAEALYNLGLAYLRLGRYEEALADYEQALELDP--DDAEALNNlGLALQALGRY 92

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489462523 171 EGALTTLLAMKERHPHNPQVLRQLQRLYQQRGDWSDVVRLM---PELRKDKVLPAKELAELERRAWGENLSLAAYREGIE 247
Cdd:COG0457   93 EEALEDYDKALELDPDDAEALYNLGLALLELGRYDEAIEAYeraLELDPDDADALYNLGIALEKLGRYEEALELLEKLEA 172

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 489462523 248 GAPTGLPSLESAWQGLASAQRQEPQLVLAYADQLRRLGAEAQAEEVLRSALKREYN 303
Cdd:COG0457  173 AALAALLAAALGEAALALAAAEVLLALLLALEQALRKKLAILTLAALAELLLLALA 228
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
92-289 1.67e-05

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 45.77  E-value: 1.67e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489462523  92 GQMDLAEGRWSSAQRHLQRAAEADTHPLLYYIGAARAANEQGRYEDCDALLERALERQPQAELAIaLNHAQLQQDRGDTE 171
Cdd:COG0457   49 GLAYLRLGRYEEALADYEQALELDPDDAEALNNLGLALQALGRYEEALEDYDKALELDPDDAEAL-YNLGLALLELGRYD 127

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489462523 172 GALTTLLAMKERHPHNPQVLRQLQRLYQQRGDWSDVVRLMPELRKDKVLPAKELAELERRAWGENLSLAAYREGIEGAPT 251
Cdd:COG0457  128 EAIEAYERALELDPDDADALYNLGIALEKLGRYEEALELLEKLEAAALAALLAAALGEAALALAAAEVLLALLLALEQAL 207

                        170       180       190
                 ....*....|....*....|....*....|....*...
gi 489462523 252 GLPSLESAWQGLASAQRQEPQLVLAYADQLRRLGAEAQ 289
Cdd:COG0457  208 RKKLAILTLAALAELLLLALALLLALRLAALALYQYRA 245
COG4700 COG4700
Uncharacterized conserved protein ECs_4300, contains TPR-like domain [Function unknown];
275-394 2.17e-05

Uncharacterized conserved protein ECs_4300, contains TPR-like domain [Function unknown];


Pssm-ID: 443735 [Multi-domain]  Cd Length: 249  Bit Score: 45.64  E-value: 2.17e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489462523 275 LAYADQLRRLGAEAQAEEVLRSALKREYNSHLARLYGLVRGSDPLKQ----LQTAEGWLKHHP----ADPSLLLslGRIC 346
Cdd:COG4700   93 VRLADALLELGRYDEAIELYEEALTGIFADDPHILLGLAQALFELGRyaeaLETLEKLIAKNPdfksSDAHLLY--ARAL 170

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 489462523 347 LQGRLWGKARDYLESSLRLERNPETCAELARLLGQLGETDRSNQLFQE 394
Cdd:COG4700  171 EALGDLEAAEAELEALARRYSGPEARYRYAKFLARQGRTAEAKELLEE 218
PRK11788 PRK11788
tetratricopeptide repeat protein; Provisional
 89-199 2.49e-05

tetratricopeptide repeat protein; Provisional


Pssm-ID: 236983 [Multi-domain]  Cd Length: 389  Bit Score: 45.96  E-value: 2.49e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489462523  89 IEQGQMDLAEGRWSSAQRHLQRAAEAD------THPLLYYigAARAANEQGRYEdcdALLERALERQPQAELAIALnhAQ 162
Cdd:PRK11788 218 ILLGDLALAQGDYAAAIEALERVEEQDpeylseVLPKLME--CYQALGDEAEGL---EFLRRALEEYPGADLLLAL--AQ 290

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 489462523 163 LQQDRGDTEGALTTLLAMKERHPhnpqVLRQLQRLYQ 199
Cdd:PRK11788 291 LLEEQEGPEAAQALLREQLRRHP----SLRGFHRLLD 323
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 92-197 1.07e-04

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 41.92  E-value: 1.07e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489462523  92 GQMDLAEGRWSSAQRHLQRAAEADTHPLLYYIGAARAANEQGRYEDCDALLERALERQPQAELAiALNHAQLQQDRGDTE 171
Cdd:COG4235   24 GRAYLRLGRYDEALAAYEKALRLDPDNADALLDLAEALLAAGDTEEAEELLERALALDPDNPEA-LYLLGLAAFQQGDYA 102

                         90       100
                 ....*....|....*....|....*....
gi 489462523 172 GALTTLLAMKERHPHNP---QVLRQLQRL 197
Cdd:COG4235  103 EAIAAWQKLLALLPADAparLLEASIAEA 131
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 104-206 1.10e-04

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 41.92  E-value: 1.10e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489462523 104 AQRHLQRAAEADTHPLLYYIGAARAANEQGRYEDCDALLERALERQPQaELAIALNHAQLQQDRGDTEGALTTLLAMKER 183
Cdd:COG4235    2 AIARLRQALAANPNDAEGWLLLGRAYLRLGRYDEALAAYEKALRLDPD-NADALLDLAEALLAAGDTEEAEELLERALAL 80

                         90       100
                 ....*....|....*....|...
gi 489462523 184 HPHNPQVLRQLQRLYQQRGDWSD 206
Cdd:COG4235   81 DPDNPEALYLLGLAAFQQGDYAE 103
PRK11447 PRK11447
cellulose synthase subunit BcsC; Provisional
 87-366 3.24e-04

cellulose synthase subunit BcsC; Provisional


Pssm-ID: 183140 [Multi-domain]  Cd Length: 1157  Bit Score: 43.15  E-value: 3.24e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489462523   87 MAIEQGQMDLAEGRWSSAQRHLQRAAEADTHPLLYYIGAARAANEQGRYEDCDALLERALERQPQAELAI-ALNHAQLQQ 165
Cdd:PRK11447  353 LLIQQGDAALKANNLAQAERLYQQARQVDNTDSYAVLGLGDVAMARKDYAAAERYYQQALRMDPGNTNAVrGLANLYRQQ 432

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489462523  166 DRGDTEGALTTLLAMKERHPHNPQVLRQLQRLYQQ------RGDWSdvvrlmpelrkdkvlpakELAELERRAwgenLSL 239
Cdd:PRK11447  433 SPEKALAFIASLSASQRRSIDDIERSLQNDRLAQQaealenQGKWA------------------QAAELQRQR----LAL 490

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489462523  240 A------AYREGIEGAPTGLPSL-ESAWQGLASAQRQEPQLVLAYADQLRRLGAEAQAEEVLRSALKREYNSHLARLYGL 312
Cdd:PRK11447  491 DpgsvwlTYRLAQDLRQAGQRSQaDALMRRLAQQKPNDPEQVYAYGLYLSGSDRDRAALAHLNTLPRAQWNSNIQELAQR 570

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 489462523  313 VRGSDPLKQLQ---------TAEGWLKHHPADPSLLLSLGRICLQGRLWGKARDYLESSLRLE 366
Cdd:PRK11447  571 LQSDQVLETANrlrdsgkeaEAEALLRQQPPSTRIDLTLADWAQQRGDYAAARAAYQRVLTRE 633
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 92-187 4.51e-04

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 40.18  E-value: 4.51e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489462523  92 GQMDLAEGRWSSAQRHLQRAAEADTHPLLYYIGAARAANEQGRYEDCDALLERALERQPQaELAIALNHAQLQQDRGDTE 171
Cdd:COG4783   45 GEILLQLGDLDEAIVLLHEALELDPDEPEARLNLGLALLKAGDYDEALALLEKALKLDPE-HPEAYLRLARAYRALGRPD 123

                         90
                 ....*....|....*.
gi 489462523 172 GALTTLLAMKERHPHN 187
Cdd:COG4783  124 EAIAALEKALELDPDD 139
CpoB COG1729
Cell division protein CpoB, coordinates peptidoglycan biosynthesis and outer membrane ...
 96-199 9.28e-04

Cell division protein CpoB, coordinates peptidoglycan biosynthesis and outer membrane constriction [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 441335 [Multi-domain]  Cd Length: 113  Bit Score: 38.82  E-value: 9.28e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489462523  96 LAEGRWSSAQRHLQRAAEAD-THPL----LYYIGAARAAneQGRYEDCDALLERALERQPQAELAIA--LNHAQLQQDRG 168
Cdd:COG1729    4 LKAGDYDEAIAAFKAFLKRYpNSPLapdaLYWLGEAYYA--LGDYDEAAEAFEKLLKRYPDSPKAPDalLKLGLSYLELG 81

                         90       100       110
                 ....*....|....*....|....*....|.
gi 489462523 169 DTEGALTTLLAMKERHPHNPQVLRQLQRLYQ 199
Cdd:COG1729   82 DYDKARATLEELIKKYPDSEAAKEARARLAR 112
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 275-401 2.08e-03

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 38.25  E-value: 2.08e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489462523 275 LAYADQLRRLGAEAQAEEVLRSALKREYNSHLARL---YGLVRGSDPLKQLQTAEGWLKHHPADPSLLLSLGRICLQGRL 351
Cdd:COG4783    8 YALAQALLLAGDYDEAEALLEKALELDPDNPEAFAllgEILLQLGDLDEAIVLLHEALELDPDEPEARLNLGLALLKAGD 87

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 489462523 352 WGKARDYLESSLRLE-RNPETCAELARLLGQLGETDRSNQLFQEGLGLLDE 401
Cdd:COG4783   88 YDEALALLEKALKLDpEHPEAYLRLARAYRALGRPDEAIAALEKALELDPD 138
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 92-393 2.15e-03

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 40.45  E-value: 2.15e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489462523   92 GQMDLAEGRWSSAQRHLQRAAEADTHPLLYYIGAARAANEQGRYEDCDALLER--ALERQPQAELAIALNHAQLQQdrGD 169
Cdd:TIGR02917  63 GKIYLALGDYAAAEKELRKALSLGYPKNQVLPLLARAYLLQGKFQQVLDELPGktLLDDEGAAELLALRGLAYLGL--GQ 140

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489462523  170 TEGALTTLLAMKERHPHNPQVLRQLQRLYQQRGDWSDVVRLMPELRKDKVLPAKEL---AELERRAWGENLSLAAYREGI 246
Cdd:TIGR02917 141 LELAQKSYEQALAIDPRSLYAKLGLAQLALAENRFDEARALIDEVLTADPGNVDALllkGDLLLSLGNIELALAAYRKAI 220

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489462523  247 EGAPTGLPSLesAWQGLASAQRQEPQLVLAYADQLR------------------RLGAEAQAEEVLRSALKREYNSHLAR 308
Cdd:TIGR02917 221 ALRPNNIAVL--LALATILIEAGEFEEAEKHADALLkkapnsplahylkalvdfQKKNYEDARETLQDALKSAPEYLPAL 298

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489462523  309 LY-GLVRGSdpLKQLQTAEGW----LKHHPADPSLLLSLGRICLQGRLWGKARDYLESSLRL-ERNPETCAELARLLGQL 382
Cdd:TIGR02917 299 LLaGASEYQ--LGNLEQAYQYlnqiLKYAPNSHQARRLLASIQLRLGRVDEAIATLSPALGLdPDDPAALSLLGEAYLAL 376

                         330
                  ....*....|.
gi 489462523  383 GETDRSNQLFQ 393
Cdd:TIGR02917 377 GDFEKAAEYLA 387
COG4700 COG4700
Uncharacterized conserved protein ECs_4300, contains TPR-like domain [Function unknown];
96-203 2.31e-03

Uncharacterized conserved protein ECs_4300, contains TPR-like domain [Function unknown];


Pssm-ID: 443735 [Multi-domain]  Cd Length: 249  Bit Score: 39.48  E-value: 2.31e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489462523  96 LAEGRWSSAQRHLQRAAEA----DTHPLLyyiGAARAANEQGRYEDCDALLERALE-----RQPQAELAIALNHAQLqqd 166
Cdd:COG4700  100 LELGRYDEAIELYEEALTGifadDPHILL---GLAQALFELGRYAEALETLEKLIAknpdfKSSDAHLLYARALEAL--- 173

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 489462523 167 rGDTEGALTTLLAMKERHPhNPQVLRQLQRLYQQRGD 203
Cdd:COG4700  174 -GDLEAAEAELEALARRYS-GPEARYRYAKFLARQGR 208
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 320-398 2.53e-03

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 37.68  E-value: 2.53e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489462523 320 KQLQTAEGWLKHHPADPSLLLSLGRICLQGRLWGKARDYLESSLRLE-RNPETCAELARLLGQLGETDRSNQLFQEGLGL 398
Cdd:COG4235    1 EAIARLRQALAANPNDAEGWLLLGRAYLRLGRYDEALAAYEKALRLDpDNADALLDLAEALLAAGDTEEAEELLERALAL 80
PRK11788 PRK11788
tetratricopeptide repeat protein; Provisional
 90-202 6.41e-03

tetratricopeptide repeat protein; Provisional


Pssm-ID: 236983 [Multi-domain]  Cd Length: 389  Bit Score: 38.64  E-value: 6.41e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489462523  90 EQGQMDLAEGRWSSAQRHLQRAAEADTHPLLYYIGAARAANEQGRYEDCDALLERALERQPQ--AELA--IALNHAQLqq 165
Cdd:PRK11788 185 ELAQQALARGDLDAARALLKKALAADPQCVRASILLGDLALAQGDYAAAIEALERVEEQDPEylSEVLpkLMECYQAL-- 262

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 489462523 166 drGDTEGALTTLLAMKERHPhNPQVLRQLQRLYQQRG 202
Cdd:PRK11788 263 --GDEAEGLEFLRRALEEYP-GADLLLALAQLLEEQE 296
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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