NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|489462272|ref|WP_003367473|]
View 

MULTISPECIES: bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate--cysteine ligase CoaBC [Pseudomonas]

Protein Classification

bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase( domain architecture ID 11418829)

bifunctional phosphopantothenoylcysteine decarboxylase (CoaC)/phosphopantothenate synthase (CoaB) catalyzes two steps in the biosynthesis of coenzyme A, the conjugation of cysteine to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, followed by its decarboxylation to form 4'-phosphopantotheine

EC:  4.1.1.36|6.3.2.5
Gene Ontology:  GO:0071513|GO:0010181|GO:0046872|GO:0004632|GO:0004633|GO:0015937|GO:0015941

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
CoaBC COG0452
Phosphopantothenoylcysteine synthetase/decarboxylase CoaBC [Coenzyme transport and metabolism]; ...
 4-401 0e+00

Phosphopantothenoylcysteine synthetase/decarboxylase CoaBC [Coenzyme transport and metabolism]; Phosphopantothenoylcysteine synthetase/decarboxylase CoaBC is part of the Pathway/BioSystem: Pantothenate/CoA biosynthesis


:

Pssm-ID: 440221 [Multi-domain]  Cd Length: 399  Bit Score: 632.45  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489462272   4 LYRKRIVLGVGGGIAAYKGAELVRRLRDQGAEVRVVMTRGGAEFITPLTMQALSGHPVHLDLLDPAAEAAMGHIELAKWA 83
Cdd:COG0452    2 LAGKRILLGVTGGIAAYKAAELVRLLRKAGAEVRVVMTEAATEFVTPLTFQALSGNPVYTDLFDEEAEAEMGHIELARWA 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489462272  84 DLILIAPATADLIARLAQGIANDLLTTIVLATDATVAIAPAMNQAMWRDASVQANTRLLEERDFRVFGPASGSQACGDVG 163
Cdd:COG0452   82 DLIVIAPATANTIAKLAHGIADDLLTTTLLATTCPVLVAPAMNTNMWEHPATQRNLATLRERGVHIIGPASGELACGDVG 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489462272 164 FGRMLEADDLAQCAADCFQR-LTLTGKHVLITAGPTQENIDPVRYITNHSSGKMGFALAEAAVEAGARVTLITGPVNLPT 242
Cdd:COG0452  162 KGRMAEPEEIVEAIEALLAPkKDLAGKKVLITAGPTREPIDPVRFISNRSSGKMGYALAEAAAARGAEVTLVSGPVALPT 241

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489462272 243 PDRVSRIDVVSARDMLAACEAAIP-CDLFIASAAVADYRPEVVAPHKLKKDpsnGDGLLLQMVRNPDILATIATRPDR-P 320
Cdd:COG0452  242 PAGVERIDVESAEEMLEAVLAAFPdADIVIMAAAVADYRPAEVADQKIKKT---DDPLTLELVKNPDILAELGARKKPgQ 318

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489462272 321 FSVGFAAETEHLLDYAARKLKDKNLDLIVANDVANPSIGFNSEENACSVIDRALHATLFAQTSKAKIARQLVTFIADRMN 400
Cdd:COG0452  319 FLVGFAAETENLLENARAKLARKNLDLIVANDVSDAGAGFGSDTNAVTLLDKDGREEELPLMSKLEVARRILDEIAELLA 398


                 .
gi 489462272 401 Q 401
Cdd:COG0452  399 A 399
 
Name Accession Description Interval E-value
CoaBC COG0452
Phosphopantothenoylcysteine synthetase/decarboxylase CoaBC [Coenzyme transport and metabolism]; ...
 4-401 0e+00

Phosphopantothenoylcysteine synthetase/decarboxylase CoaBC [Coenzyme transport and metabolism]; Phosphopantothenoylcysteine synthetase/decarboxylase CoaBC is part of the Pathway/BioSystem: Pantothenate/CoA biosynthesis


Pssm-ID: 440221 [Multi-domain]  Cd Length: 399  Bit Score: 632.45  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489462272   4 LYRKRIVLGVGGGIAAYKGAELVRRLRDQGAEVRVVMTRGGAEFITPLTMQALSGHPVHLDLLDPAAEAAMGHIELAKWA 83
Cdd:COG0452    2 LAGKRILLGVTGGIAAYKAAELVRLLRKAGAEVRVVMTEAATEFVTPLTFQALSGNPVYTDLFDEEAEAEMGHIELARWA 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489462272  84 DLILIAPATADLIARLAQGIANDLLTTIVLATDATVAIAPAMNQAMWRDASVQANTRLLEERDFRVFGPASGSQACGDVG 163
Cdd:COG0452   82 DLIVIAPATANTIAKLAHGIADDLLTTTLLATTCPVLVAPAMNTNMWEHPATQRNLATLRERGVHIIGPASGELACGDVG 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489462272 164 FGRMLEADDLAQCAADCFQR-LTLTGKHVLITAGPTQENIDPVRYITNHSSGKMGFALAEAAVEAGARVTLITGPVNLPT 242
Cdd:COG0452  162 KGRMAEPEEIVEAIEALLAPkKDLAGKKVLITAGPTREPIDPVRFISNRSSGKMGYALAEAAAARGAEVTLVSGPVALPT 241

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489462272 243 PDRVSRIDVVSARDMLAACEAAIP-CDLFIASAAVADYRPEVVAPHKLKKDpsnGDGLLLQMVRNPDILATIATRPDR-P 320
Cdd:COG0452  242 PAGVERIDVESAEEMLEAVLAAFPdADIVIMAAAVADYRPAEVADQKIKKT---DDPLTLELVKNPDILAELGARKKPgQ 318

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489462272 321 FSVGFAAETEHLLDYAARKLKDKNLDLIVANDVANPSIGFNSEENACSVIDRALHATLFAQTSKAKIARQLVTFIADRMN 400
Cdd:COG0452  319 FLVGFAAETENLLENARAKLARKNLDLIVANDVSDAGAGFGSDTNAVTLLDKDGREEELPLMSKLEVARRILDEIAELLA 398


                 .
gi 489462272 401 Q 401
Cdd:COG0452  399 A 399
PRK05579 PRK05579
bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated
 1-401 0e+00

bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated


Pssm-ID: 235513 [Multi-domain]  Cd Length: 399  Bit Score: 621.00  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489462272   1 MQRLYRKRIVLGVGGGIAAYKGAELVRRLRDQGAEVRVVMTRGGAEFITPLTMQALSGHPVHLDLLDPAAEAAMGHIELA 80
Cdd:PRK05579   1 MRMLAGKRIVLGVSGGIAAYKALELVRRLRKAGADVRVVMTEAAKKFVTPLTFQALSGNPVSTDLWDPAAEAAMGHIELA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489462272  81 KWADLILIAPATADLIARLAQGIANDLLTTIVLATDATVAIAPAMNQAMWRDASVQANTRLLEERDFRVFGPASGSQACG 160
Cdd:PRK05579  81 KWADLVLIAPATADLIAKLAHGIADDLLTTTLLATTAPVLVAPAMNTQMWENPATQRNLATLRSRGVEIIGPASGRLACG 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489462272 161 DVGFGRMLEADDLAQCAADCFQRLTLTGKHVLITAGPTQENIDPVRYITNHSSGKMGFALAEAAVEAGARVTLITGPVNL 240
Cdd:PRK05579 161 DVGPGRMAEPEEIVAAAERALSPKDLAGKRVLITAGPTREPIDPVRYITNRSSGKMGYALARAAARRGADVTLVSGPVNL 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489462272 241 PTPDRVSRIDVVSARDMLAACEAAIP-CDLFIASAAVADYRPEVVAPHKLKKdpsNGDGLLLQMVRNPDILATIATR-PD 318
Cdd:PRK05579 241 PTPAGVKRIDVESAQEMLDAVLAALPqADIFIMAAAVADYRPATVAEGKIKK---GEGELTLELVPNPDILAEVAALkDK 317

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489462272 319 RPFSVGFAAETEHLLDYAARKLKDKNLDLIVANDVAnPSIGFNSEENACSVIDRALHATLFAQTSKAKIARQLVTFIADR 398
Cdd:PRK05579 318 RPFVVGFAAETGDVLEYARAKLKRKGLDLIVANDVS-AGGGFGSDDNEVTLIWSDGGEVKLPLMSKLELARRLLDEIAER 396


                 ...
gi 489462272 399 MNQ 401
Cdd:PRK05579 397 LLE 399
coaBC_dfp TIGR00521
phosphopantothenoylcysteine decarboxylase / phosphopantothenate--cysteine ligase; This model ...
 4-396 1.12e-159

phosphopantothenoylcysteine decarboxylase / phosphopantothenate--cysteine ligase; This model represents a bifunctional enzyme that catalyzes the second and third steps (cysteine ligation, EC 6.3.2.5, and decarboxylation, EC 4.1.1.36) in the biosynthesis of coenzyme A (CoA) from pantothenate in bacteria. In early descriptions of this flavoprotein, a ts mutation in one region of the protein appeared to cause a defect in DNA metaobolism rather than an increased need for the pantothenate precursor beta-alanine. This protein was then called dfp, for DNA/pantothenate metabolism flavoprotein. The authors responsible for detecting phosphopantothenate--cysteine ligase activity suggest renaming this bifunctional protein coaBC for its role in CoA biosynthesis. This enzyme contains the FMN cofactor, but no FAD or pyruvoyl group. The amino-terminal region contains the phosphopantothenoylcysteine decarboxylase activity. [Biosynthesis of cofactors, prosthetic groups, and carriers, Pantothenate and coenzyme A]


Pssm-ID: 273116 [Multi-domain]  Cd Length: 391  Bit Score: 454.52  E-value: 1.12e-159
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489462272    4 LYRKRIVLGVGGGIAAYKGAELVRRLRDQGAEVRVVMTRGGAEFITPLTMQALSGHPVHLDLLDPAAEAAMgHIELAKWA 83
Cdd:TIGR00521   1 LENKKILLGVTGGIAAYKTVELVRELVRQGAEVKVIMTEAAKKFITPLTLEALSGHKVVTELWGPIEHNAL-HIDLAKWA 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489462272   84 DLILIAPATADLIARLAQGIANDLLTTIVLATDATVAIAPAMNQAMWRDASVQANTRLLEERDFRVFGPASGSQACGDVG 163
Cdd:TIGR00521  80 DLILIAPATANTISKIAHGIADDLVSTTALAASAPIILAPAMNENMYNNPAVQENIKRLKDDGYIFIEPRSGLLACGDEG 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489462272  164 FGRMLEADDLAQCAADCF-QRLTLTGKHVLITAGPTQENIDPVRYITNHSSGKMGFALAEAAVEAGARVTLITGPVNLPT 242
Cdd:TIGR00521 160 KGRLAEPETIVKAAEREFsPKEDLEGKRVLITAGPTREPIDPVRFISNLSSGKMGLALAEAAYKRGADVTLITGPVSLLT 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489462272  243 PDRVSRIDVVSARDML--AACEAAIPCDLFIASAAVADYRPEVVAPHKLKKdpsNGDGLLLQMVRNPDILATIATRPDRP 320
Cdd:TIGR00521 240 PPGVKSIKVSTAEEMLeaALNELAKDFDIFISAAAVADFKPKTVFEGKIKK---QGEELSLKLVKNPDIIAEVRKIKKHQ 316

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 489462272  321 FSVGFAAET-EHLLDYAARKLKDKNLDLIVANDVANPSiGFNSEENACSVIDRALHATLfAQTSKAKIARQLVTFIA 396
Cdd:TIGR00521 317 VIVGFKAETnDDLIKYAKEKLKKKNLDMIVANDVSQGR-GFGSDENEVYIFSKHGHKEL-PLMSKLEVAERILDEIK 391
DFP pfam04127
DNA / pantothenate metabolism flavoprotein; The DNA/pantothenate metabolism flavoprotein (EC:4. ...
 186-366 4.44e-101

DNA / pantothenate metabolism flavoprotein; The DNA/pantothenate metabolism flavoprotein (EC:4.1.1.36) affects synthesis of DNA, and pantothenate metabolism.


Pssm-ID: 461186 [Multi-domain]  Cd Length: 183  Bit Score: 297.78  E-value: 4.44e-101
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489462272  186 LTGKHVLITAGPTQENIDPVRYITNHSSGKMGFALAEAAVEAGARVTLITGPVNLPTPDRVSRIDVVSARDMLAACEAAI 265
Cdd:pfam04127   1 LAGKRVLVTAGPTREPIDPVRFISNRSSGKMGYALARAAAARGAEVTLVSGPTSLPPPPGVEVVDVESAEEMLEAVLAAF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489462272  266 P-CDLFIASAAVADYRPEVVAPHKLKKDpSNGDGLLLQMVRNPDILATIATRPDRPFSVGFAAETEHLLDYAARKLKDKN 344
Cdd:pfam04127  81 PeADIVIMAAAVADYRPAEVADGKIKKS-SGGEELTLELVKNPDILAELGKRKPGQLLVGFAAETEDLLENARAKLERKN 159

                         170       180
                  ....*....|....*....|..
gi 489462272  345 LDLIVANDVANPSIGFNSEENA 366
Cdd:pfam04127 160 LDLIVANDVSRPGAGFGSDTNE 181
 
Name Accession Description Interval E-value
CoaBC COG0452
Phosphopantothenoylcysteine synthetase/decarboxylase CoaBC [Coenzyme transport and metabolism]; ...
 4-401 0e+00

Phosphopantothenoylcysteine synthetase/decarboxylase CoaBC [Coenzyme transport and metabolism]; Phosphopantothenoylcysteine synthetase/decarboxylase CoaBC is part of the Pathway/BioSystem: Pantothenate/CoA biosynthesis


Pssm-ID: 440221 [Multi-domain]  Cd Length: 399  Bit Score: 632.45  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489462272   4 LYRKRIVLGVGGGIAAYKGAELVRRLRDQGAEVRVVMTRGGAEFITPLTMQALSGHPVHLDLLDPAAEAAMGHIELAKWA 83
Cdd:COG0452    2 LAGKRILLGVTGGIAAYKAAELVRLLRKAGAEVRVVMTEAATEFVTPLTFQALSGNPVYTDLFDEEAEAEMGHIELARWA 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489462272  84 DLILIAPATADLIARLAQGIANDLLTTIVLATDATVAIAPAMNQAMWRDASVQANTRLLEERDFRVFGPASGSQACGDVG 163
Cdd:COG0452   82 DLIVIAPATANTIAKLAHGIADDLLTTTLLATTCPVLVAPAMNTNMWEHPATQRNLATLRERGVHIIGPASGELACGDVG 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489462272 164 FGRMLEADDLAQCAADCFQR-LTLTGKHVLITAGPTQENIDPVRYITNHSSGKMGFALAEAAVEAGARVTLITGPVNLPT 242
Cdd:COG0452  162 KGRMAEPEEIVEAIEALLAPkKDLAGKKVLITAGPTREPIDPVRFISNRSSGKMGYALAEAAAARGAEVTLVSGPVALPT 241

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489462272 243 PDRVSRIDVVSARDMLAACEAAIP-CDLFIASAAVADYRPEVVAPHKLKKDpsnGDGLLLQMVRNPDILATIATRPDR-P 320
Cdd:COG0452  242 PAGVERIDVESAEEMLEAVLAAFPdADIVIMAAAVADYRPAEVADQKIKKT---DDPLTLELVKNPDILAELGARKKPgQ 318

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489462272 321 FSVGFAAETEHLLDYAARKLKDKNLDLIVANDVANPSIGFNSEENACSVIDRALHATLFAQTSKAKIARQLVTFIADRMN 400
Cdd:COG0452  319 FLVGFAAETENLLENARAKLARKNLDLIVANDVSDAGAGFGSDTNAVTLLDKDGREEELPLMSKLEVARRILDEIAELLA 398


                 .
gi 489462272 401 Q 401
Cdd:COG0452  399 A 399
PRK05579 PRK05579
bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated
 1-401 0e+00

bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated


Pssm-ID: 235513 [Multi-domain]  Cd Length: 399  Bit Score: 621.00  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489462272   1 MQRLYRKRIVLGVGGGIAAYKGAELVRRLRDQGAEVRVVMTRGGAEFITPLTMQALSGHPVHLDLLDPAAEAAMGHIELA 80
Cdd:PRK05579   1 MRMLAGKRIVLGVSGGIAAYKALELVRRLRKAGADVRVVMTEAAKKFVTPLTFQALSGNPVSTDLWDPAAEAAMGHIELA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489462272  81 KWADLILIAPATADLIARLAQGIANDLLTTIVLATDATVAIAPAMNQAMWRDASVQANTRLLEERDFRVFGPASGSQACG 160
Cdd:PRK05579  81 KWADLVLIAPATADLIAKLAHGIADDLLTTTLLATTAPVLVAPAMNTQMWENPATQRNLATLRSRGVEIIGPASGRLACG 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489462272 161 DVGFGRMLEADDLAQCAADCFQRLTLTGKHVLITAGPTQENIDPVRYITNHSSGKMGFALAEAAVEAGARVTLITGPVNL 240
Cdd:PRK05579 161 DVGPGRMAEPEEIVAAAERALSPKDLAGKRVLITAGPTREPIDPVRYITNRSSGKMGYALARAAARRGADVTLVSGPVNL 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489462272 241 PTPDRVSRIDVVSARDMLAACEAAIP-CDLFIASAAVADYRPEVVAPHKLKKdpsNGDGLLLQMVRNPDILATIATR-PD 318
Cdd:PRK05579 241 PTPAGVKRIDVESAQEMLDAVLAALPqADIFIMAAAVADYRPATVAEGKIKK---GEGELTLELVPNPDILAEVAALkDK 317

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489462272 319 RPFSVGFAAETEHLLDYAARKLKDKNLDLIVANDVAnPSIGFNSEENACSVIDRALHATLFAQTSKAKIARQLVTFIADR 398
Cdd:PRK05579 318 RPFVVGFAAETGDVLEYARAKLKRKGLDLIVANDVS-AGGGFGSDDNEVTLIWSDGGEVKLPLMSKLELARRLLDEIAER 396


                 ...
gi 489462272 399 MNQ 401
Cdd:PRK05579 397 LLE 399
coaBC_dfp TIGR00521
phosphopantothenoylcysteine decarboxylase / phosphopantothenate--cysteine ligase; This model ...
 4-396 1.12e-159

phosphopantothenoylcysteine decarboxylase / phosphopantothenate--cysteine ligase; This model represents a bifunctional enzyme that catalyzes the second and third steps (cysteine ligation, EC 6.3.2.5, and decarboxylation, EC 4.1.1.36) in the biosynthesis of coenzyme A (CoA) from pantothenate in bacteria. In early descriptions of this flavoprotein, a ts mutation in one region of the protein appeared to cause a defect in DNA metaobolism rather than an increased need for the pantothenate precursor beta-alanine. This protein was then called dfp, for DNA/pantothenate metabolism flavoprotein. The authors responsible for detecting phosphopantothenate--cysteine ligase activity suggest renaming this bifunctional protein coaBC for its role in CoA biosynthesis. This enzyme contains the FMN cofactor, but no FAD or pyruvoyl group. The amino-terminal region contains the phosphopantothenoylcysteine decarboxylase activity. [Biosynthesis of cofactors, prosthetic groups, and carriers, Pantothenate and coenzyme A]


Pssm-ID: 273116 [Multi-domain]  Cd Length: 391  Bit Score: 454.52  E-value: 1.12e-159
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489462272    4 LYRKRIVLGVGGGIAAYKGAELVRRLRDQGAEVRVVMTRGGAEFITPLTMQALSGHPVHLDLLDPAAEAAMgHIELAKWA 83
Cdd:TIGR00521   1 LENKKILLGVTGGIAAYKTVELVRELVRQGAEVKVIMTEAAKKFITPLTLEALSGHKVVTELWGPIEHNAL-HIDLAKWA 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489462272   84 DLILIAPATADLIARLAQGIANDLLTTIVLATDATVAIAPAMNQAMWRDASVQANTRLLEERDFRVFGPASGSQACGDVG 163
Cdd:TIGR00521  80 DLILIAPATANTISKIAHGIADDLVSTTALAASAPIILAPAMNENMYNNPAVQENIKRLKDDGYIFIEPRSGLLACGDEG 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489462272  164 FGRMLEADDLAQCAADCF-QRLTLTGKHVLITAGPTQENIDPVRYITNHSSGKMGFALAEAAVEAGARVTLITGPVNLPT 242
Cdd:TIGR00521 160 KGRLAEPETIVKAAEREFsPKEDLEGKRVLITAGPTREPIDPVRFISNLSSGKMGLALAEAAYKRGADVTLITGPVSLLT 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489462272  243 PDRVSRIDVVSARDML--AACEAAIPCDLFIASAAVADYRPEVVAPHKLKKdpsNGDGLLLQMVRNPDILATIATRPDRP 320
Cdd:TIGR00521 240 PPGVKSIKVSTAEEMLeaALNELAKDFDIFISAAAVADFKPKTVFEGKIKK---QGEELSLKLVKNPDIIAEVRKIKKHQ 316

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 489462272  321 FSVGFAAET-EHLLDYAARKLKDKNLDLIVANDVANPSiGFNSEENACSVIDRALHATLfAQTSKAKIARQLVTFIA 396
Cdd:TIGR00521 317 VIVGFKAETnDDLIKYAKEKLKKKNLDMIVANDVSQGR-GFGSDENEVYIFSKHGHKEL-PLMSKLEVAERILDEIK 391
PRK13982 PRK13982
bifunctional SbtC-like/phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; ...
 6-399 9.52e-132

bifunctional SbtC-like/phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Provisional


Pssm-ID: 172484 [Multi-domain]  Cd Length: 475  Bit Score: 386.80  E-value: 9.52e-132
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489462272   6 RKRIVLGVGGGIAAYKGAELVRRLRDQGAEVRVVMTRGGAEFITPLTMQALSGHPVHLDLLDPAAEAAMGHIELAKWADL 85
Cdd:PRK13982  70 SKRVTLIIGGGIAAYKALDLIRRLKERGAHVRCVLTKAAQQFVTPLTASALSGQRVYTDLFDPESEFDAGHIRLARDCDL 149

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489462272  86 ILIAPATADLIARLAQGIANDLLTTIVLATDATVAIAPAMNQAMWRDASVQANTRLLEERDFRVFGPASGSQA-CGDVGF 164
Cdd:PRK13982 150 IVVAPATADLMAKMANGLADDLASAILLAANRPILLAPAMNPLMWNNPATRRNVAQLKRDGVHMIGPNAGEMAeRGEAGV 229

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489462272 165 GRMLEADDLAQCAA---DCFQRLTLTGKHVLITAGPTQENIDPVRYITNHSSGKMGFALAEAAVEAGARVTLITGPVNLP 241
Cdd:PRK13982 230 GRMAEPLEIAAAAEallRPPQPKPLAGRRVLITAGPTHEPIDPVRYIANRSSGKQGFAIAAAAAAAGAEVTLISGPVDLA 309

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489462272 242 TPDRVSRIDVVSARDMLAACEAAIPCDLFIASAAVADYRPEVVAPHKLKKDPsnGDGLLLQMVRNPDILATIATRPDR-- 319
Cdd:PRK13982 310 DPQGVKVIHVESARQMLAAVEAALPADIAIFAAAVADWRVATEGGQKLKKGA--AGPPPLQLVENPDILATISKLAENrp 387

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489462272 320 PFSVGFAAETEHLLDYAARKLKDKNLDLIVANDVANPSIGFNSEENACSVIDR---ALHATLFAQTSKAKIARQLVTFIA 396
Cdd:PRK13982 388 PLVIGFAAETEHLIDNARAKLARKGCDWIVANDVSPATGVMGGDRNTVHLLSRdgdAEKVESWPVMTKDEVATALVARIA 467


                 ...
gi 489462272 397 DRM 399
Cdd:PRK13982 468 STF 470
DFP pfam04127
DNA / pantothenate metabolism flavoprotein; The DNA/pantothenate metabolism flavoprotein (EC:4. ...
 186-366 4.44e-101

DNA / pantothenate metabolism flavoprotein; The DNA/pantothenate metabolism flavoprotein (EC:4.1.1.36) affects synthesis of DNA, and pantothenate metabolism.


Pssm-ID: 461186 [Multi-domain]  Cd Length: 183  Bit Score: 297.78  E-value: 4.44e-101
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489462272  186 LTGKHVLITAGPTQENIDPVRYITNHSSGKMGFALAEAAVEAGARVTLITGPVNLPTPDRVSRIDVVSARDMLAACEAAI 265
Cdd:pfam04127   1 LAGKRVLVTAGPTREPIDPVRFISNRSSGKMGYALARAAAARGAEVTLVSGPTSLPPPPGVEVVDVESAEEMLEAVLAAF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489462272  266 P-CDLFIASAAVADYRPEVVAPHKLKKDpSNGDGLLLQMVRNPDILATIATRPDRPFSVGFAAETEHLLDYAARKLKDKN 344
Cdd:pfam04127  81 PeADIVIMAAAVADYRPAEVADGKIKKS-SGGEELTLELVKNPDILAELGKRKPGQLLVGFAAETEDLLENARAKLERKN 159

                         170       180
                  ....*....|....*....|..
gi 489462272  345 LDLIVANDVANPSIGFNSEENA 366
Cdd:pfam04127 160 LDLIVANDVSRPGAGFGSDTNE 181
PRK07313 PRK07313
phosphopantothenoylcysteine decarboxylase; Validated
 6-185 2.07e-65

phosphopantothenoylcysteine decarboxylase; Validated


Pssm-ID: 235986 [Multi-domain]  Cd Length: 182  Bit Score: 206.34  E-value: 2.07e-65
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489462272   6 RKRIVLGVGGGIAAYKGAELVRRLRDQGAEVRVVMTRGGAEFITPLTMQALSGHPVHLDLLDPAAEAAMGHIELAKWADL 85
Cdd:PRK07313   1 MKNILLAVSGSIAAYKAADLTSQLTKRGYQVTVLMTKAATKFITPLTLQVLSKNPVHLDVMDEHDPKLMNHIELAKRADL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489462272  86 ILIAPATADLIARLAQGIANDLLTTIVLATDATVA--IAPAMNQAMWRDASVQANTRLLEERDFRVFGPASGSQACGDVG 163
Cdd:PRK07313  81 FLVAPATANTIAKLAHGIADDLVTSVALALPATTPklIAPAMNTKMYENPATQRNLKTLKEDGVQEIEPKEGLLACGDEG 160

                        170       180
                 ....*....|....*....|..
gi 489462272 164 FGRMLEADDLAQCAADCFQRLT 185
Cdd:PRK07313 161 YGALADIETILETIENTLKEKT 182
coaC_strep TIGR02113
phosphopantothenoylcysteine decarboxylase, streptococcal; In most bacteria, a single ...
 7-176 2.15e-50

phosphopantothenoylcysteine decarboxylase, streptococcal; In most bacteria, a single bifunctional protein catalyses phosphopantothenoylcysteine decarboxylase and phosphopantothenate--cysteine ligase activities, sequential steps in coenzyme A biosynthesis (see TIGR00521). These activities reside in separate proteins encoded by tandem genes in some bacterial lineages. This model describes proteins from the genera Streptococcus and Enterococcus homologous to the N-terminal region of TIGR00521, corresponding to phosphopantothenoylcysteine decarboxylase activity. [Biosynthesis of cofactors, prosthetic groups, and carriers, Pantothenate and coenzyme A]


Pssm-ID: 131168  Cd Length: 177  Bit Score: 167.68  E-value: 2.15e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489462272    7 KRIVLGVGGGIAAYKGAELVRRLRDQGAEVRVVMTRGGAEFITPLTMQALSGHPVHLDLLDPAAEAAMGHIELAKWADLI 86
Cdd:TIGR02113   1 KKILLAVTGSIAAYKAADLTSQLTKLGYDVTVLMTQAATQFITPLTLQVLSKNPVHLDVMDEHDPKVINHIELAKKADLF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489462272   87 LIAPATADLIARLAQGIANDLLTTIVLATDATVA--IAPAMNQAMWRDASVQANTRLLEERDFRVFGPASGSQACGDVGF 164
Cdd:TIGR02113  81 LVAPASANTIAHLAHGFADNIVTSVALALPPETPklIAPAMNTKMYQNPITQRNIKILKKIGYQEIQPKESLLACGDYGR 160

                         170
                  ....*....|..
gi 489462272  165 GRMLEADDLAQC 176
Cdd:TIGR02113 161 GALADLDDILQT 172
Flavoprotein pfam02441
Flavoprotein; This family contains diverse flavoprotein enzymes. This family includes ...
 7-179 1.44e-36

Flavoprotein; This family contains diverse flavoprotein enzymes. This family includes epidermin biosynthesis protein, EpiD, which has been shown to be a flavoprotein that binds FMN. This enzyme catalyzes the removal of two reducing equivalents from the cysteine residue of the C-terminal meso-lanthionine of epidermin to form a --C==C-- double bond. This family also includes the B chain of dipicolinate synthase a small polar molecule that accumulates to high concentrations in bacterial endospores, and is thought to play a role in spore heat resistance, or the maintenance of heat resistance. dipicolinate synthase catalyzes the formation of dipicolinic acid from dihydroxydipicolinic acid. This family also includes phenyl-acrylic acid decarboxylase (EC:4.1.1.-).


Pssm-ID: 426775 [Multi-domain]  Cd Length: 177  Bit Score: 131.34  E-value: 1.44e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489462272    7 KRIVLGVGGGIAAYKGAELVRRLRDQGAEVRVVMTRGGAEFITPLTMQALSGHpVHLDLLDPAAEAAMGHIEL---AKWA 83
Cdd:pfam02441   1 KRILVGITGSSAAIKALRLLEELKKEGAEVRVIMTKAAKKVITPETLAALSEN-VDEDLTWRELDDDILHIELasgARWA 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489462272   84 DLILIAPATADLIARLAQGIANDLLT----------------TIVLATDATVAIAPAMNQAMWRDASVQANTRLLEERDf 147
Cdd:pfam02441  80 DAMVIAPASANTLAKIANGIADNLLTraadvalkerrphlenMLTLTAKKPIIIAPAMNTAMYENPATLENLEDLKADG- 158

                         170       180       190
                  ....*....|....*....|....*....|..
gi 489462272  148 rvfgpasgsqacgdvGFGRMLEADDLAQCAAD 179
Cdd:pfam02441 159 ---------------GKGRMPEPEAIVGKVLD 175
PRK06732 PRK06732
phosphopantothenate--cysteine ligase; Validated
 191-355 2.15e-23

phosphopantothenate--cysteine ligase; Validated


Pssm-ID: 235856 [Multi-domain]  Cd Length: 229  Bit Score: 97.37  E-value: 2.15e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489462272 191 VLITAGPTQENIDPVRYITNHSSGKMGFALAEAAVEAGARVTLITGPVNL-PTP-DRVSRIDVVSARDMLAACEAAIP-C 267
Cdd:PRK06732   3 ILITSGGTTEPIDSVRGITNHSTGQLGKIIAETFLAAGHEVTLVTTKTAVkPEPhPNLSIIEIENVDDLLETLEPLVKdH 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489462272 268 DLFIASAAVADYRPEVVA-----------------PHKLKKDPSNGDGLLLQMVRNPDILATIATRPDRPFSVGFA---- 326
Cdd:PRK06732  83 DVLIHSMAVSDYTPVYMTdleevsasdnlnefltkQNTEAKISSASDYQVLFLKKTPKVISYVKKWNPNITLVGFKllvn 162

                        170       180
                 ....*....|....*....|....*....
gi 489462272 327 AETEHLLDYAARKLKDKNLDLIVANDVAN 355
Cdd:PRK06732 163 VSKEELIKVARASLIKNQADYILANDLTD 191
PLN02496 PLN02496
probable phosphopantothenoylcysteine decarboxylase
 6-169 2.74e-22

probable phosphopantothenoylcysteine decarboxylase


Pssm-ID: 215274  Cd Length: 209  Bit Score: 93.88  E-value: 2.74e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489462272   6 RKRIVLGVGGGIAAYKGAELVRRLrDQGAEVRVVMTRGGAEFITPLTMqalsghPVHLDLLDPAAEAA----MG----HI 77
Cdd:PLN02496  19 KPRILLAASGSVAAIKFGNLCHCF-SEWAEVRAVVTKASLHFIDRASL------PKDVTLYTDEDEWSswnkIGdsvlHI 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489462272  78 ELAKWADLILIAPATADLIARLAQGIANDLLTTIVLATDAT--VAIAPAMNQAMWRDASVQANTRLLEERDFRVFGPASG 155
Cdd:PLN02496  92 ELRRWADVMVIAPLSANTLGKIAGGLCDNLLTCIVRAWDYSkpLFVAPAMNTFMWNNPFTERHLMSIDELGISLIPPVTK 171

                        170
                 ....*....|....
gi 489462272 156 SQACGDVGFGRMLE 169
Cdd:PLN02496 172 RLACGDYGNGAMAE 185
PRK09620 PRK09620
hypothetical protein; Provisional
 186-351 6.33e-08

hypothetical protein; Provisional


Pssm-ID: 181997  Cd Length: 229  Bit Score: 52.97  E-value: 6.33e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489462272 186 LTGKHVLITAGPTQENIDPVRYITNHSSGKMGFALAEAAVEAGARVTLITG-----PVNLPTPDRVSRID-VVSARDMLA 259
Cdd:PRK09620   1 MKGKKVLITSGGCLEKWDQVRGHTNMAKGTIGRIIAEELISKGAHVIYLHGyfaekPNDINNQLELHPFEgIIDLQDKMK 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489462272 260 ACEAAIPCDLFIASAAVADYRPEVVAPHKLKKDPSNGD-----GLLLQMVRNPDILATIATRPDRPFSVGFAAET----E 330
Cdd:PRK09620  81 SIITHEKVDAVIMAAAGSDWVVDKICDQEGNVLDMNGKissdiAPIIHFQKAPKVLKQIKQWDPETVLVGFKLESdvneE 160

                        170       180
                 ....*....|....*....|.
gi 489462272 331 HLLDYAARKLKDKNLDLIVAN 351
Cdd:PRK09620 161 ELFERAKNRMEEAKASVMIAN 181
PRK05920 PRK05920
aromatic acid decarboxylase; Validated
 7-109 7.95e-03

aromatic acid decarboxylase; Validated


Pssm-ID: 180312  Cd Length: 204  Bit Score: 37.52  E-value: 7.95e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489462272   7 KRIVLGVGGGIAAYKGAELVRRLRDQGAEVRVVMTRGGAEFI---TPLTMQALSGHPVHLdlLDPAAEAAMGHIELAKWA 83
Cdd:PRK05920   4 KRIVLAITGASGAIYGVRLLECLLAADYEVHLVISKAAQKVLateTGLKLPAVPDLAEAF--LREQLGAAAGQLRVHGKD 81

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 489462272  84 DL-------------ILIAPATADLIARLAQGIANDLLT 109
Cdd:PRK05920  82 DWgapiasgsfrtdgMVIAPCSMGTLAAIAHGLSDNLIE 120
AfpA COG1036
Archaeal flavoprotein [Energy production and conversion];
84-116 9.20e-03

Archaeal flavoprotein [Energy production and conversion];


Pssm-ID: 440659 [Multi-domain]  Cd Length: 174  Bit Score: 36.72  E-value: 9.20e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*
gi 489462272  84 DLILIAPATADLIARLAQGIANDLLT------------TIVLATD 116
Cdd:COG1036   81 DTLVIAPATSNTVAKIVLGIADTLVTnavaqagkgrvpSIVFPCD 125
spoVFB PRK08305
dipicolinate synthase subunit B; Reviewed
 3-129 9.92e-03

dipicolinate synthase subunit B; Reviewed


Pssm-ID: 181370 [Multi-domain]  Cd Length: 196  Bit Score: 37.18  E-value: 9.92e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489462272   3 RLYRKRIVLGVGGGIAAYKGA-ELVRRLRDQGAEVRVVMTRG----------GAEFITplTMQALSGHPVHLDLldPAAE 71
Cdd:PRK08305   2 SLKGKRIGFGLTGSHCTYDEVmPEIEKLVDEGAEVTPIVSYTvqttdtrfgkAEEWIK--KIEEITGNKVINTI--VEAE 77

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 489462272  72 AamghIELAKWADLILIAPATADLIARLAQGIANdllTTIVLATDAT------VAIAPAMNQAM 129
Cdd:PRK08305  78 P----LGPKKLLDCMVIAPCTGNTMAKLANAITD---SPVLMAAKATlrnqrpVVLAISTNDAL 134
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH