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Conserved domains on  [gi|489242334|ref|WP_003150544|]
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MULTISPECIES: recombinase family protein [Bacteria]

Protein Classification

recombinase family protein( domain architecture ID 10132964)

recombinase family protein is a serine recombinase that catalyzes the site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining mechanism which involves a transient phosphoserine linkage between DNA and the enzyme

CATH:  3.40.50.1390
Gene Ontology:  GO:0015074|GO:0000150|GO:0003677|GO:0006310
PubMed:  11972771|16077726|9348666|21645851|26104451
SCOP:  3000065

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
SR_ResInv cd03768
Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members ...
 2-126 1.67e-58

Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining mechanism which involves a transient phosphoserine linkage between DNA and the enzyme. They are functionally versatile and include resolvases, invertases, integrases, and transposases. Resolvases and invertases affect resolution or inversion and comprise a major phylogenic group. Resolvases (e.g. Tn3, gamma-delta, and Tn5044) normally recombine two sites in direct repeat causing deletion of the DNA between the sites. Invertases (e.g. Gin and Hin) recombine sites in inverted repeat to invert the DNA between the sites. Cointegrate resolution with gamma-delta resolvase requires the formation of a synaptosome of three resolvase dimers bound to each of two res sites on the DNA. Also included in this subfamily are some putative integrases including a sequence from bacteriophage phi-FC1.


:

Pssm-ID: 239737 [Multi-domain]  Cd Length: 126  Bit Score: 183.84  E-value: 1.67e-58
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489242334   2 KIGYARVSTRDQKADLQVDALKQAG-CERIYQDIASGAKSARPELDKLLANVRPGDAVVIWKLDRLGRSLKHLVELVGEL 80
Cdd:cd03768    1 VIGYARVSTDDQSLERQLEALKAAGeCDKIFEEKGSGGKKERPELQKLLEDLREGDTLVVTKLDRLGRSTKDLLEIVEEL 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 489242334  81 AERKVGLQSLNDPIDTTHAQGRLVFNLFASLAEFERELIRERTQAG 126
Cdd:cd03768   81 REKGVSLRSLTEGIDTSTPSGKLMLTILGAFAEFERELIRERTKEG 126
SpoIVCA COG1961
Site-specific DNA recombinase SpoIVCA/DNA invertase PinE [Replication, recombination and ...
 1-256 2.87e-48

Site-specific DNA recombinase SpoIVCA/DNA invertase PinE [Replication, recombination and repair];


:

Pssm-ID: 441564 [Multi-domain]  Cd Length: 388  Bit Score: 165.58  E-value: 2.87e-48
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489242334   1 MKIGYARVSTRDQKA---DLQVDALKQ----AGCE--RIYQDIA-SGAKSARPELDKLLANVRPG--DAVVIWKLDRLGR 68
Cdd:COG1961    3 RAAGYARVSTDDQEGlslERQREALRAyaekAGWEivRIYVDEGvSGTSKDRPGLQRLLADLRAGkfDTLVVWKLDRLGR 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489242334  69 SLKHLVELVGELAERKVGLQSLNDPIDTTHAQGRLVFNLFASLAEFERELIRERTQAGLSAARARGRIGGR-------PK 141
Cdd:COG1961   83 NLADLLELVEELKERGVRLISLTEGIDTSTPMGRLLLTILAAFAEFERELISERTRAGLAAAKARGKYLGRppygyrdPK 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489242334 142 GLPAKAEATAMAAE--TLYREGRlSVSAIGEKLH------ISKSTLYSYLRHRGVEIGAYQKSARSRDQQPSAASPAEPP 213
Cdd:COG1961  163 KLVIDEEEAEVVRRifELYLEGK-SLREIARELNergiptWSRSTVYRILKNPVYGGLGVYGLGKKIVTEKGERKVRRRR 241

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|...
gi 489242334 214 AAERVATVTLRLAVVNNSKFVRGRKRATENIERYCLEPYGMKR 256
Cdd:COG1961  242 KRRVIREEEERVRRRELAAKRARRLLKGKLLRGLRGRKKRGGG 284
 
Name Accession Description Interval E-value
SR_ResInv cd03768
Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members ...
 2-126 1.67e-58

Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining mechanism which involves a transient phosphoserine linkage between DNA and the enzyme. They are functionally versatile and include resolvases, invertases, integrases, and transposases. Resolvases and invertases affect resolution or inversion and comprise a major phylogenic group. Resolvases (e.g. Tn3, gamma-delta, and Tn5044) normally recombine two sites in direct repeat causing deletion of the DNA between the sites. Invertases (e.g. Gin and Hin) recombine sites in inverted repeat to invert the DNA between the sites. Cointegrate resolution with gamma-delta resolvase requires the formation of a synaptosome of three resolvase dimers bound to each of two res sites on the DNA. Also included in this subfamily are some putative integrases including a sequence from bacteriophage phi-FC1.


Pssm-ID: 239737 [Multi-domain]  Cd Length: 126  Bit Score: 183.84  E-value: 1.67e-58
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489242334   2 KIGYARVSTRDQKADLQVDALKQAG-CERIYQDIASGAKSARPELDKLLANVRPGDAVVIWKLDRLGRSLKHLVELVGEL 80
Cdd:cd03768    1 VIGYARVSTDDQSLERQLEALKAAGeCDKIFEEKGSGGKKERPELQKLLEDLREGDTLVVTKLDRLGRSTKDLLEIVEEL 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 489242334  81 AERKVGLQSLNDPIDTTHAQGRLVFNLFASLAEFERELIRERTQAG 126
Cdd:cd03768   81 REKGVSLRSLTEGIDTSTPSGKLMLTILGAFAEFERELIRERTKEG 126
SpoIVCA COG1961
Site-specific DNA recombinase SpoIVCA/DNA invertase PinE [Replication, recombination and ...
 1-256 2.87e-48

Site-specific DNA recombinase SpoIVCA/DNA invertase PinE [Replication, recombination and repair];


Pssm-ID: 441564 [Multi-domain]  Cd Length: 388  Bit Score: 165.58  E-value: 2.87e-48
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489242334   1 MKIGYARVSTRDQKA---DLQVDALKQ----AGCE--RIYQDIA-SGAKSARPELDKLLANVRPG--DAVVIWKLDRLGR 68
Cdd:COG1961    3 RAAGYARVSTDDQEGlslERQREALRAyaekAGWEivRIYVDEGvSGTSKDRPGLQRLLADLRAGkfDTLVVWKLDRLGR 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489242334  69 SLKHLVELVGELAERKVGLQSLNDPIDTTHAQGRLVFNLFASLAEFERELIRERTQAGLSAARARGRIGGR-------PK 141
Cdd:COG1961   83 NLADLLELVEELKERGVRLISLTEGIDTSTPMGRLLLTILAAFAEFERELISERTRAGLAAAKARGKYLGRppygyrdPK 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489242334 142 GLPAKAEATAMAAE--TLYREGRlSVSAIGEKLH------ISKSTLYSYLRHRGVEIGAYQKSARSRDQQPSAASPAEPP 213
Cdd:COG1961  163 KLVIDEEEAEVVRRifELYLEGK-SLREIARELNergiptWSRSTVYRILKNPVYGGLGVYGLGKKIVTEKGERKVRRRR 241

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|...
gi 489242334 214 AAERVATVTLRLAVVNNSKFVRGRKRATENIERYCLEPYGMKR 256
Cdd:COG1961  242 KRRVIREEEERVRRRELAAKRARRLLKGKLLRGLRGRKKRGGG 284
Resolvase pfam00239
Resolvase, N terminal domain; The N-terminal domain of the resolvase family (this family) ...
 3-135 3.07e-48

Resolvase, N terminal domain; The N-terminal domain of the resolvase family (this family) contains the active site and the dimer interface. The extended arm at the C-terminus of this domain connects to the C-terminal helix-turn-helix domain of resolvase - see pfam02796.


Pssm-ID: 425548 [Multi-domain]  Cd Length: 144  Bit Score: 158.20  E-value: 3.07e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489242334    3 IGYARVSTRDQKADL--QVDALKQAGCER----IYQDI-ASGAKSARPELDKLLANVRP--GDAVVIWKLDRLGRSLKHL 73
Cdd:pfam00239   2 IGYARVSTEDQDDSLerQLEALRAYAACNgkivEFEDKgVSGRKLDRPGLQRLLALLRAgkGDVLVVYKLDRLGRSLRDL 81

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 489242334   74 VELVGELAERKVGLQSLNDPIDTTHAQGRLVFNLFASLAEFERELIRERTQAGLSAARARGR 135
Cdd:pfam00239  82 LTLVEELREKGVDLVSLDEGIDTSTPMGRLLLTILAALAEFERALIRERTRAGLAAAAARGK 143
Resolvase smart00857
Resolvase, N terminal domain; The N-terminal domain of the resolvase family contains the ...
 3-135 1.88e-42

Resolvase, N terminal domain; The N-terminal domain of the resolvase family contains the active site and the dimer interface. The extended arm at the C-terminus of this domain connects to the C-terminal helix-turn-helix domain of resolvase.


Pssm-ID: 214861 [Multi-domain]  Cd Length: 148  Bit Score: 143.15  E-value: 1.88e-42
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489242334     3 IGYARVSTRDQKA---DLQVDALKQA----GCE--RIYQDIA-SGAKSARPELDKLLANVRPGD--AVVIWKLDRLGRSL 70
Cdd:smart00857   2 AGYARVSTDDQADgslERQLEALRAYaernGWEvvRIYEDEGvSGKKADRPGLQRLLADLRAGDidVLVVYKLDRLGRSL 81

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 489242334    71 KHLVELVGELAERKVGLQSLNDPI-DTTHAQGRLVFNLFASLAEFERELIRERTQAGLSAARARGR 135
Cdd:smart00857  82 RDLLALLELLEEKGVRLVSLKEGIlDTSTPAGRLLLDILAALAEFERELISERTKAGLARAAARGR 147
recomb_XisF NF041201
fdxN element excision recombinase XisF;
2-140 7.87e-31

fdxN element excision recombinase XisF;


Pssm-ID: 469105 [Multi-domain]  Cd Length: 463  Bit Score: 120.45  E-value: 7.87e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489242334   2 KIGYARVSTRDQKAD---L--QVDALKQAGCERIYQDIASGAKSARPELDKLLANVRPG--DAVVIWKLDRLGRSLKHLV 74
Cdd:NF041201   1 IVGYARVSTREQADDghaLeqQIARLKKAGASEIFFDIESGRSDKRKGFNQLLKLVKSGkvTEIIITRIDRLTRSVVTIY 80

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 489242334  75 ELVGELAERKVGLQSLNDP-IDTTHAQGRLVFNLFASLAEFERELIRERTQAGLSAARARGRIGGRP 140
Cdd:NF041201  81 KAIEVLQKKGVKLVILDAPlDDLSSPGGWFTINQLAALAEFESRLLSERVRHGLEYFREQKKAHPKP 147
mpi PRK13413
master DNA invertase Mpi family serine-type recombinase;
1-190 4.35e-18

master DNA invertase Mpi family serine-type recombinase;


Pssm-ID: 184041 [Multi-domain]  Cd Length: 200  Bit Score: 80.53  E-value: 4.35e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489242334   1 MKIGYARVSTRDQKADLQVDAL------KQAGCERIYQDIASGAKSARP-ELDKLLANVRPGDAVVIWKLDRLGRSLKHL 73
Cdd:PRK13413   1 MIYAYIRVSTDKQTVENQRFEItnfaekNNLTIDKWIEETISGTKSYKDrKLGKLLKKMRKGDILIVSELSRLGRNLMEI 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489242334  74 VELVGELAERKVGLQS------LNDPIdtthaQGRLVFNLFASLAEFERELIRERTQAGLSAARARGRIGGRPKGLPAKA 147
Cdd:PRK13413  81 MSILNICMEKEVIVYTikegyeLGDDI-----NSKVLAFAFGLSAEIERNLISQRTKEALARKKAEGVTLGRPKGSTPKK 155

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*
gi 489242334 148 EATAMAAETL--YREGRLSVSAIGEKLHISKSTLYSYLRHRGVEI 190
Cdd:PRK13413 156 YKLTGKEEKIkkLLDKGTSKSEIARKLGVSRTTLARFLKTRGLRI 200
transpos_IS607 NF033518
IS607 family transposase;
3-68 6.88e-09

IS607 family transposase;


Pssm-ID: 468054 [Multi-domain]  Cd Length: 187  Bit Score: 54.57  E-value: 6.88e-09
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 489242334   3 IGYARVSTRDQKADL--QVDALKQAGCER------IYQDIASGAKSARPELDKLLANVRPGDA--VVIWKLDRLGR 68
Cdd:NF033518  57 VIYARVSSADQKDDLerQVARLTQYATAKgwqvdeVVTDIGSGLNEKRKGLLKLLDDILNGEVsrVVVEHKDRLTR 132
COG2452 COG2452
Predicted site-specific integrase-resolvase [Mobilome: prophages, transposons];
3-75 7.63e-09

Predicted site-specific integrase-resolvase [Mobilome: prophages, transposons];


Pssm-ID: 441988 [Multi-domain]  Cd Length: 178  Bit Score: 54.23  E-value: 7.63e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489242334   3 IGYARVSTRDQKADL--QVDALKQAGCER-----IYQDIASGAKSARPELDKLLANVRPgDAVVIWKLDRLGRSLKHLVE 75
Cdd:COG2452   51 VIYARVSSADQKDDLerQVERLEEYATAKgyqdeVIKDVGSGLNYKRKGLLKLLERIEV-ERVVVEHKDRLARFGFELLE 129
 
Name Accession Description Interval E-value
SR_ResInv cd03768
Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members ...
 2-126 1.67e-58

Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining mechanism which involves a transient phosphoserine linkage between DNA and the enzyme. They are functionally versatile and include resolvases, invertases, integrases, and transposases. Resolvases and invertases affect resolution or inversion and comprise a major phylogenic group. Resolvases (e.g. Tn3, gamma-delta, and Tn5044) normally recombine two sites in direct repeat causing deletion of the DNA between the sites. Invertases (e.g. Gin and Hin) recombine sites in inverted repeat to invert the DNA between the sites. Cointegrate resolution with gamma-delta resolvase requires the formation of a synaptosome of three resolvase dimers bound to each of two res sites on the DNA. Also included in this subfamily are some putative integrases including a sequence from bacteriophage phi-FC1.


Pssm-ID: 239737 [Multi-domain]  Cd Length: 126  Bit Score: 183.84  E-value: 1.67e-58
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489242334   2 KIGYARVSTRDQKADLQVDALKQAG-CERIYQDIASGAKSARPELDKLLANVRPGDAVVIWKLDRLGRSLKHLVELVGEL 80
Cdd:cd03768    1 VIGYARVSTDDQSLERQLEALKAAGeCDKIFEEKGSGGKKERPELQKLLEDLREGDTLVVTKLDRLGRSTKDLLEIVEEL 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 489242334  81 AERKVGLQSLNDPIDTTHAQGRLVFNLFASLAEFERELIRERTQAG 126
Cdd:cd03768   81 REKGVSLRSLTEGIDTSTPSGKLMLTILGAFAEFERELIRERTKEG 126
SpoIVCA COG1961
Site-specific DNA recombinase SpoIVCA/DNA invertase PinE [Replication, recombination and ...
 1-256 2.87e-48

Site-specific DNA recombinase SpoIVCA/DNA invertase PinE [Replication, recombination and repair];


Pssm-ID: 441564 [Multi-domain]  Cd Length: 388  Bit Score: 165.58  E-value: 2.87e-48
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489242334   1 MKIGYARVSTRDQKA---DLQVDALKQ----AGCE--RIYQDIA-SGAKSARPELDKLLANVRPG--DAVVIWKLDRLGR 68
Cdd:COG1961    3 RAAGYARVSTDDQEGlslERQREALRAyaekAGWEivRIYVDEGvSGTSKDRPGLQRLLADLRAGkfDTLVVWKLDRLGR 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489242334  69 SLKHLVELVGELAERKVGLQSLNDPIDTTHAQGRLVFNLFASLAEFERELIRERTQAGLSAARARGRIGGR-------PK 141
Cdd:COG1961   83 NLADLLELVEELKERGVRLISLTEGIDTSTPMGRLLLTILAAFAEFERELISERTRAGLAAAKARGKYLGRppygyrdPK 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489242334 142 GLPAKAEATAMAAE--TLYREGRlSVSAIGEKLH------ISKSTLYSYLRHRGVEIGAYQKSARSRDQQPSAASPAEPP 213
Cdd:COG1961  163 KLVIDEEEAEVVRRifELYLEGK-SLREIARELNergiptWSRSTVYRILKNPVYGGLGVYGLGKKIVTEKGERKVRRRR 241

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|...
gi 489242334 214 AAERVATVTLRLAVVNNSKFVRGRKRATENIERYCLEPYGMKR 256
Cdd:COG1961  242 KRRVIREEEERVRRRELAAKRARRLLKGKLLRGLRGRKKRGGG 284
Resolvase pfam00239
Resolvase, N terminal domain; The N-terminal domain of the resolvase family (this family) ...
 3-135 3.07e-48

Resolvase, N terminal domain; The N-terminal domain of the resolvase family (this family) contains the active site and the dimer interface. The extended arm at the C-terminus of this domain connects to the C-terminal helix-turn-helix domain of resolvase - see pfam02796.


Pssm-ID: 425548 [Multi-domain]  Cd Length: 144  Bit Score: 158.20  E-value: 3.07e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489242334    3 IGYARVSTRDQKADL--QVDALKQAGCER----IYQDI-ASGAKSARPELDKLLANVRP--GDAVVIWKLDRLGRSLKHL 73
Cdd:pfam00239   2 IGYARVSTEDQDDSLerQLEALRAYAACNgkivEFEDKgVSGRKLDRPGLQRLLALLRAgkGDVLVVYKLDRLGRSLRDL 81

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 489242334   74 VELVGELAERKVGLQSLNDPIDTTHAQGRLVFNLFASLAEFERELIRERTQAGLSAARARGR 135
Cdd:pfam00239  82 LTLVEELREKGVDLVSLDEGIDTSTPMGRLLLTILAALAEFERALIRERTRAGLAAAAARGK 143
Resolvase smart00857
Resolvase, N terminal domain; The N-terminal domain of the resolvase family contains the ...
 3-135 1.88e-42

Resolvase, N terminal domain; The N-terminal domain of the resolvase family contains the active site and the dimer interface. The extended arm at the C-terminus of this domain connects to the C-terminal helix-turn-helix domain of resolvase.


Pssm-ID: 214861 [Multi-domain]  Cd Length: 148  Bit Score: 143.15  E-value: 1.88e-42
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489242334     3 IGYARVSTRDQKA---DLQVDALKQA----GCE--RIYQDIA-SGAKSARPELDKLLANVRPGD--AVVIWKLDRLGRSL 70
Cdd:smart00857   2 AGYARVSTDDQADgslERQLEALRAYaernGWEvvRIYEDEGvSGKKADRPGLQRLLADLRAGDidVLVVYKLDRLGRSL 81

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 489242334    71 KHLVELVGELAERKVGLQSLNDPI-DTTHAQGRLVFNLFASLAEFERELIRERTQAGLSAARARGR 135
Cdd:smart00857  82 RDLLALLELLEEKGVRLVSLKEGIlDTSTPAGRLLLDILAALAEFERELISERTKAGLARAAARGR 147
recomb_XisF NF041201
fdxN element excision recombinase XisF;
2-140 7.87e-31

fdxN element excision recombinase XisF;


Pssm-ID: 469105 [Multi-domain]  Cd Length: 463  Bit Score: 120.45  E-value: 7.87e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489242334   2 KIGYARVSTRDQKAD---L--QVDALKQAGCERIYQDIASGAKSARPELDKLLANVRPG--DAVVIWKLDRLGRSLKHLV 74
Cdd:NF041201   1 IVGYARVSTREQADDghaLeqQIARLKKAGASEIFFDIESGRSDKRKGFNQLLKLVKSGkvTEIIITRIDRLTRSVVTIY 80

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 489242334  75 ELVGELAERKVGLQSLNDP-IDTTHAQGRLVFNLFASLAEFERELIRERTQAGLSAARARGRIGGRP 140
Cdd:NF041201  81 KAIEVLQKKGVKLVILDAPlDDLSSPGGWFTINQLAALAEFESRLLSERVRHGLEYFREQKKAHPKP 147
Ser_Recombinase cd00338
Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or ...
 5-126 7.06e-26

Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining mechanism which involves a transient phosphoserine linkage between DNA and serine recombinase. Serine recombinases demonstrate functional versatility and include resolvases, invertases, integrases, and transposases. Resolvases and invertases (i.e. Tn3, gamma-delta, Tn5044 resolvases, Gin and Hin invertases) in this family contain a C-terminal DNA binding domain and comprise a major phylogenic group. Also included are phage- and bacterial-encoded recombinases such as phiC31 integrase, SpoIVCA excisionase, and Tn4451 TnpX transposase. These integrases and transposases have larger C-terminal domains compared to resolvases/invertases and are referred to as large serine recombinases. Also belonging to this family are proteins with N-terminal DNA binding domains similar to IS607- and IS1535-transposases from Helicobacter and Mycobacterium.


Pssm-ID: 238206 [Multi-domain]  Cd Length: 137  Bit Score: 99.64  E-value: 7.06e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489242334   5 YARVSTRDQKADL----QVDALKQAgCER-------IYQDIASGAKSA--RPELDKLLANV--RPGDAVVIWKLDRLGRS 69
Cdd:cd00338    2 YARVSTDKQEQGDslerQREALREY-AARnglevvgEYEDAGSSATSLvdRPGLQRLLADVkaGKIDVVLVEKLDRLSRN 80

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 489242334  70 LKHLVELVGELAERKVGLQSLNDPIDTTHAQGRLVFNLFASLAEFERELIRERTQAG 126
Cdd:cd00338   81 LVDLLELLELLEAHGVRVVTADGEIDLDSEDGRLMLGILAAMAEEESKLISERTKRG 137
mpi PRK13413
master DNA invertase Mpi family serine-type recombinase;
1-190 4.35e-18

master DNA invertase Mpi family serine-type recombinase;


Pssm-ID: 184041 [Multi-domain]  Cd Length: 200  Bit Score: 80.53  E-value: 4.35e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489242334   1 MKIGYARVSTRDQKADLQVDAL------KQAGCERIYQDIASGAKSARP-ELDKLLANVRPGDAVVIWKLDRLGRSLKHL 73
Cdd:PRK13413   1 MIYAYIRVSTDKQTVENQRFEItnfaekNNLTIDKWIEETISGTKSYKDrKLGKLLKKMRKGDILIVSELSRLGRNLMEI 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489242334  74 VELVGELAERKVGLQS------LNDPIdtthaQGRLVFNLFASLAEFERELIRERTQAGLSAARARGRIGGRPKGLPAKA 147
Cdd:PRK13413  81 MSILNICMEKEVIVYTikegyeLGDDI-----NSKVLAFAFGLSAEIERNLISQRTKEALARKKAEGVTLGRPKGSTPKK 155

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*
gi 489242334 148 EATAMAAETL--YREGRLSVSAIGEKLHISKSTLYSYLRHRGVEI 190
Cdd:PRK13413 156 YKLTGKEEKIkkLLDKGTSKSEIARKLGVSRTTLARFLKTRGLRI 200
SR_IS607_transposase_like cd03769
Serine Recombinase (SR) family, IS607-like transposase subfamily, catalytic domain; members ...
 3-68 5.42e-10

Serine Recombinase (SR) family, IS607-like transposase subfamily, catalytic domain; members contain a DNA binding domain with homology to MerR/SoxR located N-terminal to the catalytic domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining mechanism which involves a transient phosphoserine linkage between DNA and the enzyme. They are functionally versatile and include resolvases, invertases, integrases, and transposases. This subfamily is composed of proteins that catalyze the transposition of insertion sequence (IS) elements such as IS607 from Helicobacter and IS1535 from Mycobacterium, and similar proteins from other bacteria and several archaeal species. IS elements are DNA segments that move to new sites in prokaryotic and eukaryotic genomes causing insertion mutations and gene rearrangements.


Pssm-ID: 239738  Cd Length: 134  Bit Score: 56.50  E-value: 5.42e-10
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 489242334   3 IGYARVSTRDQKADL--QVDALKQAGCER-----IYQDIASGAKSARPELDKLLANVRPG--DAVVIWKLDRLGR 68
Cdd:cd03769    2 VLYARVSSHDQKDDLerQIERLEAYATAQgwiveVIKDIGSGLNEKRKGLLKLLEDVLAGkvERVVITYKDRLAR 76
SR_Res_par cd03767
Serine recombinase (SR) family, Partitioning (par)-Resolvase subfamily, catalytic domain; ...
 4-99 6.25e-10

Serine recombinase (SR) family, Partitioning (par)-Resolvase subfamily, catalytic domain; Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining mechanism which involves a transient phosphoserine linkage between DNA and the enzyme. They are functionally versatile and include resolvases, invertases, integrases, and transposases. This subgroup is composed of proteins similar to the E. coli resolvase found in the par region of the RP4 plasmid, which encodes a highly efficient partitioning system. This protein is part of a complex stabilization system involved in the resolution of plasmid dimers during cell division. Similar to Tn3 and other resolvases, members of this family may contain a C-terminal DNA binding domain.


Pssm-ID: 239736 [Multi-domain]  Cd Length: 146  Bit Score: 56.56  E-value: 6.25e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489242334   4 GYARVSTRDQKADLQVDALKQAGCER------IYQDIASGAKSARPELDKLLANVRPGDAVVIWKLDRLGR-SLKHLVEL 76
Cdd:cd03767    3 AYLRASTDEQDATRAKESLEAFATERgfyiagFYVENASGAKLDRPELFRLLDDAQSGDVLLVEQIDRLSRlPLDDWETL 82

                         90       100
                 ....*....|....*....|...
gi 489242334  77 VGELAERKVGLQSLNDPidTTHA 99
Cdd:cd03767   83 KASIAAKGLRVVSLDLP--TSHS 103
transpos_IS607 NF033518
IS607 family transposase;
3-68 6.88e-09

IS607 family transposase;


Pssm-ID: 468054 [Multi-domain]  Cd Length: 187  Bit Score: 54.57  E-value: 6.88e-09
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 489242334   3 IGYARVSTRDQKADL--QVDALKQAGCER------IYQDIASGAKSARPELDKLLANVRPGDA--VVIWKLDRLGR 68
Cdd:NF033518  57 VIYARVSSADQKDDLerQVARLTQYATAKgwqvdeVVTDIGSGLNEKRKGLLKLLDDILNGEVsrVVVEHKDRLTR 132
COG2452 COG2452
Predicted site-specific integrase-resolvase [Mobilome: prophages, transposons];
3-75 7.63e-09

Predicted site-specific integrase-resolvase [Mobilome: prophages, transposons];


Pssm-ID: 441988 [Multi-domain]  Cd Length: 178  Bit Score: 54.23  E-value: 7.63e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489242334   3 IGYARVSTRDQKADL--QVDALKQAGCER-----IYQDIASGAKSARPELDKLLANVRPgDAVVIWKLDRLGRSLKHLVE 75
Cdd:COG2452   51 VIYARVSSADQKDDLerQVERLEEYATAKgyqdeVIKDVGSGLNYKRKGLLKLLERIEV-ERVVVEHKDRLARFGFELLE 129
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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