NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|489233585|ref|WP_003141891|]
View 

MULTISPECIES: two-component system sensor histidine kinase DctB [Pseudomonas]

Protein Classification

sensor histidine kinase( domain architecture ID 11467953)

sensor histidine kinase may be part of a two-component regulatory system and function as a protein kinase that phosphorylates a target protein in response to a signal

CATH:  3.30.565.10
EC:  2.7.13.3
Gene Ontology:  GO:0000156|GO:0000155|GO:0004673|GO:0007165|GO:0005524
PubMed:  10339418|11406410|10966457|8029829|18076326|11489844
SCOP:  4001957

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
COG4191 COG4191
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal ...
 255-595 2.71e-80

Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms];


:

Pssm-ID: 443345 [Multi-domain]  Cd Length: 361  Bit Score: 257.42  E-value: 2.71e-80
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489233585 255 LRLQQSAWLSQSRTLPETGWTVSIYAPRTLIERPVRSVLLIGGATLLALLLLLTLLTLSRRHYLDRIALEAEAKRQLEER 334
Cdd:COG4191   18 LALALALLLLLLLLLLALLLLLLALLLALLALLLLLLLLLLLLLLELLLLLLALLGGLLRLLLLLGLLLLLLLEALLLLL 97

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489233585 335 VLERTRELENANAQLQQEVHEREQAQRELMRAQDEVVQAGKLTALGTMSASISHELNQPLAAIRSYADNARVLLDHQ-RT 413
Cdd:COG4191   98 LAALDAEENAELEELERDITELERAEEELRELQEQLVQSEKLAALGELAAGIAHEINNPLAAILGNAELLRRRLEDEpDP 177

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489233585 414 EDARGNLEQISDLTTRMASIIAHLKAYARGARRAPENVQLQPAIEDALSMLASRRRAMNVELLRDVPDAPLWVQAGETRL 493
Cdd:COG4191  178 EELREALERILEGAERAAEIVRSLRAFSRRDEEEREPVDLNELIDEALELLRPRLKARGIEVELDLPPDLPPVLGDPGQL 257

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489233585 494 RQILGNLLTNALDALAEKAPPrRLWVIASQDQHGVILTLRDNGPGFSEDALAHAHEPFFTTKTTAKGLGLGLAICDNLLR 573
Cdd:COG4191  258 EQVLLNLLINAIDAMEEGEGG-RITISTRREGDYVVISVRDNGPGIPPEVLERIFEPFFTTKPVGKGTGLGLSISYGIVE 336

                        330       340
                 ....*....|....*....|..
gi 489233585 574 ALGGRLEMGNHLEGGAVVRLHL 595
Cdd:COG4191  337 KHGGRIEVESEPGGGTTFTITL 358
dCache_1 pfam02743
Cache domain; Double cache domain 1 covers the last three strands from the membrane distal ...
 48-276 7.75e-14

Cache domain; Double cache domain 1 covers the last three strands from the membrane distal PAS-like domain, the first two strands of the membrane proximal domain, and the connecting elements between the two domains. This domain when present in chemoreceptors recognize several signals such as proteinogenic amino acids, GABA, Histamine and polyamines, decanoic acid, Autoinducer-2, purine derivatives, quaternary amines, citrate and taurine, among others. When associated with histidine kinases, it recognizes C3/C4-dicarboxylic acids, Spermine, guanosine and Autoinducer-2 (Mantilla et al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1 https://doi.org/10.1093/femsre/fuab043).


:

Pssm-ID: 460673 [Multi-domain]  Cd Length: 237  Bit Score: 71.60  E-value: 7.75e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489233585   48 EQLAEQNRQTLDLYVANLLGTLRRYEELPQILGGLPVLRQALQQPgdplLQKIANEALADIRRRTGADVIYLLQPDGTTQ 127
Cdd:pfam02743   5 EQAEEQLLSLAKQLAENIESYLDSLEEILELLASNPDLQDLLSAP----AEEELAKLESLLRSNPGISSIYLVDADGRVL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489233585  128 VASNWAQADSFvhRNFAFRPYYREAMQGR---LARFFGLGTTSIKRGYYFASAVK---EGSRIIGVLVVKVDLEHIERLW 201
Cdd:pfam02743  81 ASSDESPSYPG--LDVSERPWYKEALKGGggiIWVFSSPYPSSESGEPVLTIARPiydDDGEVIGVLVADLDLDTLQELL 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489233585  202 GNSP----EQLLVIDNYGVVILSSR-EDWRFHASRPLSAAERDEIHANIPYPVQDpkplRLQQSAWLSQSRTLPETGWTV 276
Cdd:pfam02743 159 SQIKlgegGYVFIVDSDGRILAHPLgKNLRSLLAPFLGKSLADALPGSGITEIAV----DLDGEDYLVAYAPIPGTGWTL 234
 
Name Accession Description Interval E-value
COG4191 COG4191
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal ...
 255-595 2.71e-80

Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms];


Pssm-ID: 443345 [Multi-domain]  Cd Length: 361  Bit Score: 257.42  E-value: 2.71e-80
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489233585 255 LRLQQSAWLSQSRTLPETGWTVSIYAPRTLIERPVRSVLLIGGATLLALLLLLTLLTLSRRHYLDRIALEAEAKRQLEER 334
Cdd:COG4191   18 LALALALLLLLLLLLLALLLLLLALLLALLALLLLLLLLLLLLLLELLLLLLALLGGLLRLLLLLGLLLLLLLEALLLLL 97

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489233585 335 VLERTRELENANAQLQQEVHEREQAQRELMRAQDEVVQAGKLTALGTMSASISHELNQPLAAIRSYADNARVLLDHQ-RT 413
Cdd:COG4191   98 LAALDAEENAELEELERDITELERAEEELRELQEQLVQSEKLAALGELAAGIAHEINNPLAAILGNAELLRRRLEDEpDP 177

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489233585 414 EDARGNLEQISDLTTRMASIIAHLKAYARGARRAPENVQLQPAIEDALSMLASRRRAMNVELLRDVPDAPLWVQAGETRL 493
Cdd:COG4191  178 EELREALERILEGAERAAEIVRSLRAFSRRDEEEREPVDLNELIDEALELLRPRLKARGIEVELDLPPDLPPVLGDPGQL 257

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489233585 494 RQILGNLLTNALDALAEKAPPrRLWVIASQDQHGVILTLRDNGPGFSEDALAHAHEPFFTTKTTAKGLGLGLAICDNLLR 573
Cdd:COG4191  258 EQVLLNLLINAIDAMEEGEGG-RITISTRREGDYVVISVRDNGPGIPPEVLERIFEPFFTTKPVGKGTGLGLSISYGIVE 336

                        330       340
                 ....*....|....*....|..
gi 489233585 574 ALGGRLEMGNHLEGGAVVRLHL 595
Cdd:COG4191  337 KHGGRIEVESEPGGGTTFTITL 358
HATPase_c smart00387
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
 490-595 4.49e-26

Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.


Pssm-ID: 214643 [Multi-domain]  Cd Length: 111  Bit Score: 102.73  E-value: 4.49e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489233585   490 ETRLRQILGNLLTNALDALAEKApprRLWVIASQDQHGVILTLRDNGPGFSEDALAHAHEPFFTTKTTA---KGLGLGLA 566
Cdd:smart00387   3 PDRLRQVLSNLLDNAIKYTPEGG---RITVTLERDGDHVEITVEDNGPGIPPEDLEKIFEPFFRTDKRSrkiGGTGLGLS 79

                           90       100
                   ....*....|....*....|....*....
gi 489233585   567 ICDNLLRALGGRLEMGNHLEGGAVVRLHL 595
Cdd:smart00387  80 IVKKLVELHGGEISVESEPGGGTTFTITL 108
PRK11360 PRK11360
two-component system sensor histidine kinase AtoS;
362-595 6.96e-26

two-component system sensor histidine kinase AtoS;


Pssm-ID: 236901 [Multi-domain]  Cd Length: 607  Bit Score: 112.37  E-value: 6.96e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489233585 362 ELMRAQDEVVQAGKLTALGTMSASISHELNQPLAAIRSYAdnaRVLLDHQRTEDARGNLEQISDLTTRMASIIAHLKAYA 441
Cdd:PRK11360 373 ERKRLQRRVARQERLAALGELVAGVAHEIRNPLTAIRGYV---QIWRQQTSDPPSQEYLSVVLREVDRLNKVIDQLLEFS 449

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489233585 442 RGARRAPENVQLQPAIEDALSMLASRRRAMNVELLRDV-PDAPLWVQAGEtRLRQILGNLLTNALDALAEKAPPR-RLWV 519
Cdd:PRK11360 450 RPRESQWQPVSLNALVEEVLQLFQTAGVQARVDFETELdNELPPIWADPE-LLKQVLLNILINAVQAISARGKIRiRTWQ 528

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 489233585 520 IASQDQHgviLTLRDNGPGFSEDALAHAHEPFFTTKttAKGLGLGLAICDNLLRALGGRLEMGNHLEGGAVVRLHL 595
Cdd:PRK11360 529 YSDGQVA---VSIEDNGCGIDPELLKKIFDPFFTTK--AKGTGLGLALSQRIINAHGGDIEVESEPGVGTTFTLYL 599
HATPase_HupT_MifS-like cd16976
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 493-595 9.60e-25

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhodobacter capsulatus HupT and Pseudomonas aeruginosa MifS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Rhodobacter capsulatus HupT of the HupT-HupR two-component regulatory system (TCS), which regulates the synthesis of HupSL, a membrane bound [NiFe]hydrogenase. It also contains the HATPase domain of Pseudomonas aeruginosa MifS, the HK of the MifS-MifR TCS, which may be involved in sensing alpha-ketoglutarate and regulating its transport and subsequent metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some also have a C-terminal PAS sensor domain.


Pssm-ID: 340435 [Multi-domain]  Cd Length: 102  Bit Score: 98.68  E-value: 9.60e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489233585 493 LRQILGNLLTNALDALAEKAPPRrLWVIASQDQHGVILTLRDNGPGFSEDALAHAHEPFFTTKTTAKGLGLGLAICDNLL 572
Cdd:cd16976    1 IQQVLMNLLQNALDAMGKVENPR-IRIAARRLGGRLVLVVRDNGPGIAEEHLSRVFDPFFTTKPVGKGTGLGLSISYGIV 79

                         90       100
                 ....*....|....*....|...
gi 489233585 573 RALGGRLEMGNHLEGGAVVRLHL 595
Cdd:cd16976   80 EEHGGRLSVANEEGAGARFTFDL 102
HATPase_c pfam02518
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the ...
 490-595 2.38e-24

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.


Pssm-ID: 460579 [Multi-domain]  Cd Length: 109  Bit Score: 97.82  E-value: 2.38e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489233585  490 ETRLRQILGNLLTNALDAlaeKAPPRRLWVIASQDQHgVILTLRDNGPGFSEDALAHAHEPFFTT-KTTAKGLGLGLAIC 568
Cdd:pfam02518   3 ELRLRQVLSNLLDNALKH---AAKAGEITVTLSEGGE-LTLTVEDNGIGIPPEDLPRIFEPFSTAdKRGGGGTGLGLSIV 78

                          90       100
                  ....*....|....*....|....*..
gi 489233585  569 DNLLRALGGRLEMGNHLEGGAVVRLHL 595
Cdd:pfam02518  79 RKLVELLGGTITVESEPGGGTTVTLTL 105
nifL_nitrog TIGR02938
nitrogen fixation negative regulator NifL; NifL is a modulator of the nitrogen fixation ...
 356-588 3.88e-15

nitrogen fixation negative regulator NifL; NifL is a modulator of the nitrogen fixation positive regulator protein NifA, and is therefore a negative regulator. It binds NifA. NifA and NifL are encoded by adjacent genes. [Central intermediary metabolism, Nitrogen fixation, Regulatory functions, Protein interactions]


Pssm-ID: 131984 [Multi-domain]  Cd Length: 494  Bit Score: 78.41  E-value: 3.88e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489233585  356 REQAQRELMRA-QDEVVQAGKLTALG-TMSASIsHELNQPLAAIRSyadNARVLldhQRTEDARGNLEQISDLTTRMASI 433
Cdd:TIGR02938 252 REEQERARLSAlQALMAEEERLEAIReTLSAAI-HRLQGPMNLISA---AISVL---QRRGDDAGNPASAAMLQQALSAG 324

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489233585  434 IAHLKAYARGARRAPEN----VQLQPAIEDALSMLASRRRAMNVeLLRDVPDAPL-WVQAGETRLRQILGNLLTNALDAL 508
Cdd:TIGR02938 325 REHMEALRQVIPQSPQEivvpVNLNQILRDVITLSTPRLLAAGI-VVDWQPAATLpAILGRELQLRSLFKALVDNAIEAM 403

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489233585  509 AEKAPPRR-LWVIASQDQHGVILTLRDNGPGFSEDALAHAHEPFFTTK-TTAKGLGLGLAICDNLLRALGGRLEMGNHLE 586
Cdd:TIGR02938 404 NIKGWKRReLSITTALNGDLIVVSILDSGPGIPQDLRYKVFEPFFTTKgGSRKHIGMGLSVAQEIVADHGGIIDLDDDYS 483


                  ..
gi 489233585  587 GG 588
Cdd:TIGR02938 484 EG 485
dCache_1 pfam02743
Cache domain; Double cache domain 1 covers the last three strands from the membrane distal ...
 48-276 7.75e-14

Cache domain; Double cache domain 1 covers the last three strands from the membrane distal PAS-like domain, the first two strands of the membrane proximal domain, and the connecting elements between the two domains. This domain when present in chemoreceptors recognize several signals such as proteinogenic amino acids, GABA, Histamine and polyamines, decanoic acid, Autoinducer-2, purine derivatives, quaternary amines, citrate and taurine, among others. When associated with histidine kinases, it recognizes C3/C4-dicarboxylic acids, Spermine, guanosine and Autoinducer-2 (Mantilla et al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1 https://doi.org/10.1093/femsre/fuab043).


Pssm-ID: 460673 [Multi-domain]  Cd Length: 237  Bit Score: 71.60  E-value: 7.75e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489233585   48 EQLAEQNRQTLDLYVANLLGTLRRYEELPQILGGLPVLRQALQQPgdplLQKIANEALADIRRRTGADVIYLLQPDGTTQ 127
Cdd:pfam02743   5 EQAEEQLLSLAKQLAENIESYLDSLEEILELLASNPDLQDLLSAP----AEEELAKLESLLRSNPGISSIYLVDADGRVL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489233585  128 VASNWAQADSFvhRNFAFRPYYREAMQGR---LARFFGLGTTSIKRGYYFASAVK---EGSRIIGVLVVKVDLEHIERLW 201
Cdd:pfam02743  81 ASSDESPSYPG--LDVSERPWYKEALKGGggiIWVFSSPYPSSESGEPVLTIARPiydDDGEVIGVLVADLDLDTLQELL 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489233585  202 GNSP----EQLLVIDNYGVVILSSR-EDWRFHASRPLSAAERDEIHANIPYPVQDpkplRLQQSAWLSQSRTLPETGWTV 276
Cdd:pfam02743 159 SQIKlgegGYVFIVDSDGRILAHPLgKNLRSLLAPFLGKSLADALPGSGITEIAV----DLDGEDYLVAYAPIPGTGWTL 234
PDC1_DGC_like cd12914
first PDC (PhoQ/DcuS/CitA) domain of diguanylate-cyclase and similar domains; Members of this ...
 84-194 4.65e-04

first PDC (PhoQ/DcuS/CitA) domain of diguanylate-cyclase and similar domains; Members of this subfamily display varying domain architectures but all contain double PDC (PhoQ/DcuS/CitA) sensor domains. This model represents the first PDC domain of Diguanylate-cyclases (DGCs), Histidine kinases (HKs), and other similar domains. Many members of this subfamily contain a C-terminal DGC (also called GGDEF) domain. DGCs regulate the turnover of cyclic diguanosine monophosphate. HK receptors are part of two-component systems (TCS) in bacteria that play a critical role for sensing and adapting to environmental changes. Typically, HK receptors contain an extracellular sensing domain flanked by two transmembrane helices, an intracellular dimerization histidine phosphorylation domain (DHp), and a C-terminal kinase domain, with many variations on this theme. In the case of HKs, signals detected by the sensor domain are transmitted through DHp to the kinase domain, resulting in the phosphorylation of a conserved histidine residue in DHp; phosphotransfer to a conserved aspartate in its cognate response regulator (RR) follows, which leads to the activation of genes for downstream cellular responses.


Pssm-ID: 350339  Cd Length: 123  Bit Score: 40.45  E-value: 4.65e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489233585  84 VLRQALQQPGDPLLQKIANEALADIRRRT-GADVIYLLQPDGTTQVASNwaqADSFVHRNFAFRPYYREAMQGRLARFFG 162
Cdd:cd12914   11 LADDLEARGAASADPAALQALLRRLLARLpEVRSIFVVDADGRVVASSG---PGPAPGLDVSDRDYFQAARAGGGGLFIS 87

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 489233585 163 ---LGTTSIKRGYYFASAVK-EGSRIIGVLVVKVDL 194
Cdd:cd12914   88 epvISRVTGKPVIPLSRPIRdADGRFAGVVVASIDL 123
 
Name Accession Description Interval E-value
COG4191 COG4191
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal ...
 255-595 2.71e-80

Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms];


Pssm-ID: 443345 [Multi-domain]  Cd Length: 361  Bit Score: 257.42  E-value: 2.71e-80
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489233585 255 LRLQQSAWLSQSRTLPETGWTVSIYAPRTLIERPVRSVLLIGGATLLALLLLLTLLTLSRRHYLDRIALEAEAKRQLEER 334
Cdd:COG4191   18 LALALALLLLLLLLLLALLLLLLALLLALLALLLLLLLLLLLLLLELLLLLLALLGGLLRLLLLLGLLLLLLLEALLLLL 97

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489233585 335 VLERTRELENANAQLQQEVHEREQAQRELMRAQDEVVQAGKLTALGTMSASISHELNQPLAAIRSYADNARVLLDHQ-RT 413
Cdd:COG4191   98 LAALDAEENAELEELERDITELERAEEELRELQEQLVQSEKLAALGELAAGIAHEINNPLAAILGNAELLRRRLEDEpDP 177

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489233585 414 EDARGNLEQISDLTTRMASIIAHLKAYARGARRAPENVQLQPAIEDALSMLASRRRAMNVELLRDVPDAPLWVQAGETRL 493
Cdd:COG4191  178 EELREALERILEGAERAAEIVRSLRAFSRRDEEEREPVDLNELIDEALELLRPRLKARGIEVELDLPPDLPPVLGDPGQL 257

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489233585 494 RQILGNLLTNALDALAEKAPPrRLWVIASQDQHGVILTLRDNGPGFSEDALAHAHEPFFTTKTTAKGLGLGLAICDNLLR 573
Cdd:COG4191  258 EQVLLNLLINAIDAMEEGEGG-RITISTRREGDYVVISVRDNGPGIPPEVLERIFEPFFTTKPVGKGTGLGLSISYGIVE 336

                        330       340
                 ....*....|....*....|..
gi 489233585 574 ALGGRLEMGNHLEGGAVVRLHL 595
Cdd:COG4191  337 KHGGRIEVESEPGGGTTFTITL 358
NtrY COG5000
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism ...
 369-595 2.21e-48

Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms];


Pssm-ID: 444024 [Multi-domain]  Cd Length: 422  Bit Score: 174.38  E-value: 2.21e-48
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489233585 369 EVVQAGKLTALGTMSASISHELNQPLAAIRSYADNARVLLDHQRTEDA---RGNLEQISDLTTRMASIIAHLKAYARGAR 445
Cdd:COG5000  191 ELLRAERLAAWGELARRIAHEIKNPLTPIQLSAERLRRKLADKLEEDRedlERALDTIIRQVDRLKRIVDEFLDFARLPE 270

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489233585 446 RAPENVQLQPAIEDALSMLASRRRAMNVELLRDVPDAPLWVQAGETRLRQILGNLLTNALDALAEKApprRLWVIASQDQ 525
Cdd:COG5000  271 PQLEPVDLNELLREVLALYEPALKEKDIRLELDLDPDLPEVLADRDQLEQVLINLLKNAIEAIEEGG---EIEVSTRRED 347

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489233585 526 HGVILTLRDNGPGFSEDALAHAHEPFFTTKTtaKGLGLGLAICDNLLRALGGRLEMGNHLEGGAVVRLHL 595
Cdd:COG5000  348 GRVRIEVSDNGPGIPEEVLERIFEPFFTTKP--KGTGLGLAIVKKIVEEHGGTIELESRPGGGTTFTIRL 415
BaeS COG0642
Signal transduction histidine kinase [Signal transduction mechanisms];
276-595 6.60e-47

Signal transduction histidine kinase [Signal transduction mechanisms];


Pssm-ID: 440407 [Multi-domain]  Cd Length: 328  Bit Score: 167.78  E-value: 6.60e-47
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489233585 276 VSIYAPRTLIERPVRSVLLIGGATLLALLLLLTLLTLSRRHYLDRIALEAEAKRQLEERVLERTRELENANAQLQQEVHE 355
Cdd:COG0642   15 LLLLLLALLLLLLLLLLLALLLLLALLLLLLLLLLLLLLLALALLALLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLL 94

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489233585 356 REQAQRELMRAQDEvvqagkltALGTMSASISHELNQPLAAIRSYADnarvLLDHQRTEDARGNLEQISDLTTRMASIIA 435
Cdd:COG0642   95 LLLALLLLLEEANE--------AKSRFLANVSHELRTPLTAIRGYLE----LLLEELDEEQREYLETILRSADRLLRLIN 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489233585 436 HLKAYAR----GARRAPENVQLQPAIEDALSMLASRRRAMNVELLRDVPDAPLWVQAGETRLRQILGNLLTNALDALAEK 511
Cdd:COG0642  163 DLLDLSRleagKLELEPEPVDLAELLEEVVELFRPLAEEKGIELELDLPDDLPTVRGDPDRLRQVLLNLLSNAIKYTPEG 242

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489233585 512 appRRLWVIASQDQHGVILTLRDNGPGFSEDALAHAHEPFFTTK--TTAKGLGLGLAICDNLLRALGGRLEMGNHLEGGA 589
Cdd:COG0642  243 ---GTVTVSVRREGDRVRISVEDTGPGIPPEDLERIFEPFFRTDpsRRGGGTGLGLAIVKRIVELHGGTIEVESEPGKGT 319


                 ....*.
gi 489233585 590 VVRLHL 595
Cdd:COG0642  320 TFTVTL 325
COG4192 COG4192
Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal ...
 319-595 1.39e-41

Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal transduction mechanisms];


Pssm-ID: 443346 [Multi-domain]  Cd Length: 640  Bit Score: 159.47  E-value: 1.39e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489233585 319 DRIALEAEAKRQLEERVLERTRELEnanaqlqQEVHEREQAQRELMRAQDEVVQAGKLTALGTMSASISHELNQPLAAIR 398
Cdd:COG4192  380 DEIGRIARLLRVFRDQAIEKTQELE-------TEIEERKRIEKNLRQTQDELIQAAKMAVVGQTMTSLAHELNQPLNAMS 452

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489233585 399 SYADNARVLLDHQRTEDARGNLEQISDLTTRMASIIAHLKAYARGARRAPENVQLQPAIEDALSMLASRRRAMNVELlrD 478
Cdd:COG4192  453 MYLFSAKKALEQENYAQLPTSLDKIEGLIERMDKIIKSLRQFSRKSDTPLQPVDLRQVIEQAWELVESRAKPQQITL--H 530

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489233585 479 VPDaPLWVQAGETRLRQILGNLLTNALDALAEkapPRRLWVIASQDQHGVILTLRDNGPGFseDALAHAHEPFFTTKTTa 558
Cdd:COG4192  531 IPD-DLMVQGDQVLLEQVLVNLLVNALDAVAT---QPQISVDLLSNAENLRVAISDNGNGW--PLVDKLFTPFTTTKEV- 603

                        250       260       270
                 ....*....|....*....|....*....|....*..
gi 489233585 559 kGLGLGLAICDNLLRALGGRLEMGNHLEGGAVVRLHL 595
Cdd:COG4192  604 -GLGLGLSICRSIMQQFGGDLYLASTLERGAMVILEF 639
KdpD COG2205
K+-sensing histidine kinase KdpD [Signal transduction mechanisms];
352-595 4.22e-41

K+-sensing histidine kinase KdpD [Signal transduction mechanisms];


Pssm-ID: 441807 [Multi-domain]  Cd Length: 239  Bit Score: 149.29  E-value: 4.22e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489233585 352 EVHEREQAQRELMRAQDEVVqagkltalgtmsASISHELNQPLAAIRSYADnarVLLDHQR--TEDARGNLEQISDLTTR 429
Cdd:COG2205    1 ELEEALEELEELERLKSEFL------------ANVSHELRTPLTSILGAAE---LLLDEEDlsPEERRELLEIIRESAER 65

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489233585 430 MASIIAHLKAYAR----GARRAPENVQLQPAIEDALSMLASRRRAMNVELLRDVPDAPLWVQAGETRLRQILGNLLTNAL 505
Cdd:COG2205   66 LLRLIEDLLDLSRlesgKLSLELEPVDLAELLEEAVEELRPLAEEKGIRLELDLPPELPLVYADPELLEQVLANLLDNAI 145

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489233585 506 DAlaekAPP-RRLWVIASQDQHGVILTLRDNGPGFSEDALAHAHEPFFTTKTT--AKGLGLGLAICDNLLRALGGRLEMG 582
Cdd:COG2205  146 KY----SPPgGTITISARREGDGVRISVSDNGPGIPEEELERIFERFYRGDNSrgEGGTGLGLAIVKRIVEAHGGTIWVE 221

                        250
                 ....*....|...
gi 489233585 583 NHLEGGAVVRLHL 595
Cdd:COG2205  222 SEPGGGTTFTVTL 234
NtrB COG3852
Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms];
351-595 7.25e-38

Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms];


Pssm-ID: 443061 [Multi-domain]  Cd Length: 361  Bit Score: 143.83  E-value: 7.25e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489233585 351 QEVHEREQAQRELMRAQdevvqagKLTALGTMSASISHELNQPLAAIRSYADnarVLLDHQRTEDARGNLEQISDLTTRM 430
Cdd:COG3852  114 RDITERKRLERELRRAE-------KLAAVGELAAGLAHEIRNPLTGIRGAAQ---LLERELPDDELREYTQLIIEEADRL 183

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489233585 431 ASIIAHLKAYARGARRAPENVQLQPAIEDALSMLASRRRAmNVELLRDVPDAPLWVQAGETRLRQILGNLLTNALDALAE 510
Cdd:COG3852  184 NNLVDRLLSFSRPRPPEREPVNLHEVLERVLELLRAEAPK-NIRIVRDYDPSLPEVLGDPDQLIQVLLNLVRNAAEAMPE 262

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489233585 511 K-------APPRRLWVIASQDQHGVILTLRDNGPGFSEDALAHAHEPFFTTKttAKGLGLGLAICDNLLRALGGRLEMGN 583
Cdd:COG3852  263 GgtitirtRVERQVTLGGLRPRLYVRIEVIDNGPGIPEEILDRIFEPFFTTK--EKGTGLGLAIVQKIVEQHGGTIEVES 340

                        250
                 ....*....|..
gi 489233585 584 HLEGGAVVRLHL 595
Cdd:COG3852  341 EPGKGTTFRIYL 352
WalK COG5002
Sensor histidine kinase WalK [Signal transduction mechanisms];
293-595 6.00e-36

Sensor histidine kinase WalK [Signal transduction mechanisms];


Pssm-ID: 444026 [Multi-domain]  Cd Length: 390  Bit Score: 139.30  E-value: 6.00e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489233585 293 LLIGGATLLALLLLLTLLTLSRRHYLDRIALEAEAKRQLEERVLERTRELENANAQLQQEVHEREQAQRELMRAQDEVVq 372
Cdd:COG5002   91 LLLLLLLLLALLILLLLLALLILLAALLLLLSELLLLLLLLGRLSLRLSALLLGLLLLAAVERDITELERLEQMRREFV- 169

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489233585 373 agkltalgtmsASISHELNQPLAAIRSYADnarVLLDHQR--TEDARGNLEQISDLTTRMASIIAHLKAYAR----GARR 446
Cdd:COG5002  170 -----------ANVSHELRTPLTSIRGYLE---LLLDGAAddPEERREYLEIILEEAERLSRLVNDLLDLSRlesgELKL 235

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489233585 447 APENVQLQPAIEDALSMLASRRRAMNVELLRDVPDAPLWVQAGETRLRQILGNLLTNALDAlaekAPP-RRLWVIASQDQ 525
Cdd:COG5002  236 EKEPVDLAELLEEVVEELRPLAEEKGIELELDLPEDPLLVLGDPDRLEQVLTNLLDNAIKY----TPEgGTITVSLREED 311

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 489233585 526 HGVILTLRDNGPGFSEDALAHAHEPFFTTKT----TAKGLGLGLAICDNLLRALGGRLEMGNHLEGGAVVRLHL 595
Cdd:COG5002  312 DQVRISVRDTGIGIPEEDLPRIFERFYRVDKsrsrETGGTGLGLAIVKHIVEAHGGRIWVESEPGKGTTFTITL 385
COG4251 COG4251
Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal ...
 103-595 3.42e-29

Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms];


Pssm-ID: 443393 [Multi-domain]  Cd Length: 503  Bit Score: 121.43  E-value: 3.42e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489233585 103 EALADIRRRTGADVIYLLQPDGTTQVASNWAQADSFVHRNFAFRPYYREAMQGRLARFFGLGTTSIKRGYYFASAVKEGS 182
Cdd:COG4251   39 ALLVLLLLLIRLLLLLLLSLLALLLLLLLLLLLLLVLAALALLLLLLLLELALVLLALLLVLLLLLALLLLLALLLLLEL 118

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489233585 183 RIIGVLVVKVDLEHIERLWGNSPEQLLVIDNYGVVILSSREDWRFHASRPLSAAERDEIHANIPYPVQDPKPLRLQQSAW 262
Cdd:COG4251  119 LLLLLALLLLLLLLALLLLEELALLRLALALLLLLLLLLLLLLLLLALILALLLAALAELELLLLLLLVLLLLLLLLLLL 198

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489233585 263 LSQSRTLPETGWTVSIYAPRTLIERPVRSVLLIGGATLLALLLLLTLLTLSRRHYLDRIALEAEakrQLEERVLERTREL 342
Cdd:COG4251  199 LLLLLRLLLELLLLLEAELLLSLGGGLGLLLLLLLLLVLLLLLILLLLLLILVLELLELRLELE---ELEEELEERTAEL 275

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489233585 343 ENANAQLQQevhereqaqrelmraqdevvqagkltalgtMSASISHELNQPLAAIRSYADNARVLLDHQRTEDARGNLEQ 422
Cdd:COG4251  276 ERSNEELEQ------------------------------FAYVASHDLREPLRKISGFSQLLEEDYGDKLDEEGREYLER 325

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489233585 423 ISDLTTRMASIIAHLKAYARGARRA--PENVQLQPAIEDALSMLASRRRAMNVELlrDVPDAPlWVQAGETRLRQILGNL 500
Cdd:COG4251  326 IRDAAERMQALIDDLLAYSRVGRQEleFEPVDLNELLEEVLEDLEPRIEERGAEI--EVGPLP-TVRGDPTLLRQVFQNL 402

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489233585 501 LTNALDALAEKAPPrRLWVIASQDQHGVILTLRDNGPGFSEDALAHAHEPFFT--TKTTAKGLGLGLAICDNLLRALGGR 578
Cdd:COG4251  403 ISNAIKYSRPGEPP-RIEIGAEREGGEWVFSVRDNGIGIDPEYAEKIFEIFQRlhSRDEYEGTGIGLAIVKKIVERHGGR 481

                        490
                 ....*....|....*..
gi 489233585 579 LEMGNHLEGGAVVRLHL 595
Cdd:COG4251  482 IWVESEPGEGATFYFTL 498
KinC COG5807
Sporulation sensor histidine kinase C [Cell cycle control, cell division, chromosome ...
 351-595 6.18e-29

Sporulation sensor histidine kinase C [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];


Pssm-ID: 444509 [Multi-domain]  Cd Length: 358  Bit Score: 118.35  E-value: 6.18e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489233585 351 QEVHEREQAQRELMRAQdevvqagKLTALGTMSASISHELNQPLAAIRSYAdnaRVLLDHQRTEDARGNLEQISDLTTRM 430
Cdd:COG5807  126 RDITKRKEAEDKLLRSE-------KLSVAGELAAGIAHEIRNPLTSIKGFL---QLLQESREDSEREEYFNIIISEIDRI 195

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489233585 431 ASIIAHLKAYARGARRAPENVQLQPAIEDALSMLASRRRAMNVELLRDVPDAPLWVQAGETRLRQILGNLLTNALDALAE 510
Cdd:COG5807  196 NTIITELLVLSKPKKFNFKKLNLNDVLEDVIALLSTEAILKNISIKYDLADDEPVINGDKNQLKQVFINLIKNAIEAMET 275

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489233585 511 KApprRLWVIASQDQHGVILTLRDNGPGFSEDALAHAHEPFFTTKTtaKGLGLGLAICDNLLRALGGRLEMGNHLEGGAV 590
Cdd:COG5807  276 GG---NITIKTYVEGDFVVISVKDEGIGIPEEVLEKIGEPFFTTKE--EGTGLGLSICKKIIEEHNGTIEVESKPGKGTT 350


                 ....*
gi 489233585 591 VRLHL 595
Cdd:COG5807  351 FTIYL 355
KinD COG5808
Sporulation sensor histidine kinase D [Cell cycle control, cell division, chromosome ...
 349-580 1.63e-26

Sporulation sensor histidine kinase D [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];


Pssm-ID: 444510 [Multi-domain]  Cd Length: 454  Bit Score: 112.92  E-value: 1.63e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489233585 349 LQQEVHEREQAQRELMRAQDEvvqAGKLTALGTMSASISHELNQPLAAIRSYADNARvlLDHQRTEDARgNLEQISDLTT 428
Cdd:COG5808  214 LLQYNLLKRKTLLERVIQEIN---TQKLELIGTFAASTAHEIRNPLTSIKGFIQLLQ--EKYPELEDQK-YFDIIQEEIQ 287

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489233585 429 RMASIIAHLKAYARgarraPENVQLQPA-----IEDALSMLASRRRAMNVELLRDVPDAPLWVQAGETRLRQILGNLLTN 503
Cdd:COG5808  288 RINQIVSEFLVLGK-----PTAKKLELDdlnelIEEILSIIDSEANLKNIRVEKQSLDEPLHIKCDKDRIKQVLLNLIKN 362

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 489233585 504 ALDALAEKappRRLWVIASQDQHGVILTLRDNGPGFSEDALAHAHEPFFTTKTTakGLGLGLAICDNLLRALGGRLE 580
Cdd:COG5808  363 AIEAMKEG---GKLTISIENDDEKAVIEVIDNGEGIPEDIIDEIFEPFVTTKEG--GTGLGLSVCKRIVEMHGGEID 434
HATPase_c smart00387
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
 490-595 4.49e-26

Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.


Pssm-ID: 214643 [Multi-domain]  Cd Length: 111  Bit Score: 102.73  E-value: 4.49e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489233585   490 ETRLRQILGNLLTNALDALAEKApprRLWVIASQDQHGVILTLRDNGPGFSEDALAHAHEPFFTTKTTA---KGLGLGLA 566
Cdd:smart00387   3 PDRLRQVLSNLLDNAIKYTPEGG---RITVTLERDGDHVEITVEDNGPGIPPEDLEKIFEPFFRTDKRSrkiGGTGLGLS 79

                           90       100
                   ....*....|....*....|....*....
gi 489233585   567 ICDNLLRALGGRLEMGNHLEGGAVVRLHL 595
Cdd:smart00387  80 IVKKLVELHGGEISVESEPGGGTTFTITL 108
PRK11360 PRK11360
two-component system sensor histidine kinase AtoS;
362-595 6.96e-26

two-component system sensor histidine kinase AtoS;


Pssm-ID: 236901 [Multi-domain]  Cd Length: 607  Bit Score: 112.37  E-value: 6.96e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489233585 362 ELMRAQDEVVQAGKLTALGTMSASISHELNQPLAAIRSYAdnaRVLLDHQRTEDARGNLEQISDLTTRMASIIAHLKAYA 441
Cdd:PRK11360 373 ERKRLQRRVARQERLAALGELVAGVAHEIRNPLTAIRGYV---QIWRQQTSDPPSQEYLSVVLREVDRLNKVIDQLLEFS 449

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489233585 442 RGARRAPENVQLQPAIEDALSMLASRRRAMNVELLRDV-PDAPLWVQAGEtRLRQILGNLLTNALDALAEKAPPR-RLWV 519
Cdd:PRK11360 450 RPRESQWQPVSLNALVEEVLQLFQTAGVQARVDFETELdNELPPIWADPE-LLKQVLLNILINAVQAISARGKIRiRTWQ 528

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 489233585 520 IASQDQHgviLTLRDNGPGFSEDALAHAHEPFFTTKttAKGLGLGLAICDNLLRALGGRLEMGNHLEGGAVVRLHL 595
Cdd:PRK11360 529 YSDGQVA---VSIEDNGCGIDPELLKKIFDPFFTTK--AKGTGLGLALSQRIINAHGGDIEVESEPGVGTTFTLYL 599
PRK11100 PRK11100
sensory histidine kinase CreC; Provisional
 385-595 9.57e-25

sensory histidine kinase CreC; Provisional


Pssm-ID: 236846 [Multi-domain]  Cd Length: 475  Bit Score: 107.62  E-value: 9.57e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489233585 385 SISHELNQPLAAIRSYADnarVLLDHQRTEDARGNLEQISDLTTRMASIIAHLKAYA----RGARRAPENVQLQPAIEDA 460
Cdd:PRK11100 262 TLTHELKSPLAAIRGAAE---LLQEDPPPEDRARFTGNILTQSARLQQLIDRLLELArleqRQELEVLEPVALAALLEEL 338

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489233585 461 LSMLASRRRAMNVELLRDVPDAplWVQAGETRLRQILGNLLTNALDAlaekAPPR-RLWVIASQDQHGVILTLRDNGPGF 539
Cdd:PRK11100 339 VEAREAQAAAKGITLRLRPDDA--RVLGDPFLLRQALGNLLDNAIDF----SPEGgTITLSAEVDGEQVALSVEDQGPGI 412

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 489233585 540 SEDALAHAHEPFFTT---KTTAKGLGLGLAICDNLLRALGGRLEMGNHLEGGAVVRLHL 595
Cdd:PRK11100 413 PDYALPRIFERFYSLprpANGRKSTGLGLAFVREVARLHGGEVTLRNRPEGGVLATLTL 471
HATPase_HupT_MifS-like cd16976
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 493-595 9.60e-25

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhodobacter capsulatus HupT and Pseudomonas aeruginosa MifS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Rhodobacter capsulatus HupT of the HupT-HupR two-component regulatory system (TCS), which regulates the synthesis of HupSL, a membrane bound [NiFe]hydrogenase. It also contains the HATPase domain of Pseudomonas aeruginosa MifS, the HK of the MifS-MifR TCS, which may be involved in sensing alpha-ketoglutarate and regulating its transport and subsequent metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some also have a C-terminal PAS sensor domain.


Pssm-ID: 340435 [Multi-domain]  Cd Length: 102  Bit Score: 98.68  E-value: 9.60e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489233585 493 LRQILGNLLTNALDALAEKAPPRrLWVIASQDQHGVILTLRDNGPGFSEDALAHAHEPFFTTKTTAKGLGLGLAICDNLL 572
Cdd:cd16976    1 IQQVLMNLLQNALDAMGKVENPR-IRIAARRLGGRLVLVVRDNGPGIAEEHLSRVFDPFFTTKPVGKGTGLGLSISYGIV 79

                         90       100
                 ....*....|....*....|...
gi 489233585 573 RALGGRLEMGNHLEGGAVVRLHL 595
Cdd:cd16976   80 EEHGGRLSVANEEGAGARFTFDL 102
HATPase_c pfam02518
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the ...
 490-595 2.38e-24

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.


Pssm-ID: 460579 [Multi-domain]  Cd Length: 109  Bit Score: 97.82  E-value: 2.38e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489233585  490 ETRLRQILGNLLTNALDAlaeKAPPRRLWVIASQDQHgVILTLRDNGPGFSEDALAHAHEPFFTT-KTTAKGLGLGLAIC 568
Cdd:pfam02518   3 ELRLRQVLSNLLDNALKH---AAKAGEITVTLSEGGE-LTLTVEDNGIGIPPEDLPRIFEPFSTAdKRGGGGTGLGLSIV 78

                          90       100
                  ....*....|....*....|....*..
gi 489233585  569 DNLLRALGGRLEMGNHLEGGAVVRLHL 595
Cdd:pfam02518  79 RKLVELLGGTITVESEPGGGTTVTLTL 105
KinE COG5809
Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome ...
 355-595 1.86e-22

Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];


Pssm-ID: 444511 [Multi-domain]  Cd Length: 489  Bit Score: 100.82  E-value: 1.86e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489233585 355 EREQAQrELMRAQDevvqagKLTALGTMSASISHELNQPLAAIRSYADnarvLLDHQRTEDARGNLEQISDLTTRMASII 434
Cdd:COG5809  253 ERKKLE-ELLRKSE------KLSVVGELAAGIAHEIRNPLTSLKGFIQ----LLKDTIDEEQKTYLDIMLSELDRIESII 321

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489233585 435 AHLKAYARGARRAPENVQLQPAIEDALSMLASRrrAM--NV----ELLRDVPDaplwVQAGETRLRQILGNLLTNALDAL 508
Cdd:COG5809  322 SEFLVLAKPQAIKYEPKDLNTLIEEVIPLLQPQ--ALlkNVqielELEDDIPD----ILGDENQLKQVFINLLKNAIEAM 395

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489233585 509 AEkapPRRLWV-IASQDQHGVILTLRDNGPGFSEDALAHAHEPFFTTKTtaKGLGLGLAICDNLLRALGGRLEMGNHLEG 587
Cdd:COG5809  396 PE---GGNITIeTKAEDDDKVVISVTDEGCGIPEERLKKLGEPFYTTKE--KGTGLGLMVSYKIIEEHGGKITVESEVGK 470


                 ....*...
gi 489233585 588 GAVVRLHL 595
Cdd:COG5809  471 GTTFSITL 478
KinA COG5805
Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle ...
 351-595 8.80e-22

Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];


Pssm-ID: 444507 [Multi-domain]  Cd Length: 496  Bit Score: 99.04  E-value: 8.80e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489233585 351 QEVHEREQAQrELMRAQDevvqagKLTALGTMSASISHELNQPLAAIRSYadnarVLLDHQRTEDARGNLEQISDLTTRM 430
Cdd:COG5805  266 RDITEKKEAE-ELMARSE------KLSIAGQLAAGIAHEIRNPLTSIKGF-----LQLLQPGIEDKEEYFDIMLSELDRI 333

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489233585 431 ASIIAHLKAYARGARRAPENVQLQPAIEDALSMLASRRRAMNV----ELLRDVPDaplwVQAGETRLRQILGNLLTNALD 506
Cdd:COG5805  334 ESIISEFLALAKPQAVNKEKENINELIQDVVTLLETEAILHNIqirlELLDEDPF----IYCDENQIKQVFINLIKNAIE 409

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489233585 507 ALAEkapPRRLWVIASQDQHGVILTLRDNGPGFSEDALAHAHEPFFTTKTtaKGLGLGLAICDNLLRALGGRLEMGNHLE 586
Cdd:COG5805  410 AMPN---GGTITIHTEEEDNSVIIRVIDEGIGIPEERLKKLGEPFFTTKE--KGTGLGLMVSYKIIENHNGTIDIDSKVG 484


                 ....*....
gi 489233585 587 GGAVVRLHL 595
Cdd:COG5805  485 KGTTFTITL 493
KinB COG5806
Sporulation sensor histidine kinase B [Cell cycle control, cell division, chromosome ...
 360-580 8.68e-21

Sporulation sensor histidine kinase B [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];


Pssm-ID: 444508 [Multi-domain]  Cd Length: 412  Bit Score: 94.93  E-value: 8.68e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489233585 360 QRELMRaqDEVVQAGKLTALGTMSASISHELNQPLAAIRSYAD--NARVLLDHQRTEDARGNLEQISdlttRMASIIAHL 437
Cdd:COG5806  184 ENILLR--KELQRAEKLEVVSELAASIAHEVRNPLTVVRGFIQllQEPELSDEKRKQYIRIALEELD----RAEAIITDY 257

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489233585 438 KAYARGARRAPENVQLQPAIEDALSMLASRRRAMNVELLRDVPDaPLWVQAGETRLRQILGNLLTNALDALAEKApprRL 517
Cdd:COG5806  258 LTFAKPQPEKLEKIDVSEELEHVIDVLSPYANMNNVEIQTELEP-GLYIEGDRQKLQQCLINIIKNGIEAMPNGG---TL 333

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 489233585 518 WVIASQDQHGVILTLRDNGPGFSEDALAHAHEPFFTTKTtaKGLGLGLAICDNLLRALGGRLE 580
Cdd:COG5806  334 TIDVSIDKNKVIISIKDTGVGMTKEQLERLGEPYFSTKE--KGTGLGTMVSYRIIEAMNGTIR 394
PRK13837 PRK13837
two-component system VirA-like sensor kinase;
356-610 1.09e-20

two-component system VirA-like sensor kinase;


Pssm-ID: 237526 [Multi-domain]  Cd Length: 828  Bit Score: 96.67  E-value: 1.09e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489233585 356 REQAQRELMRAQDEvvQAGKLTALGTMSASISHELNQPLAAIRSYADNARVLLDhqRTEDARGNLEQISDLTTRMASIIA 435
Cdd:PRK13837 429 RLETERDALERRLE--HARRLEAVGTLASGIAHNFNNILGAILGYAEMALNKLA--RHSRAARYIDEIISAGARARLIID 504

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489233585 436 HLKAYARGARRAPENVQLQPAIEDALSMLasrRRAM--NVELLRDVPDAPLWVQAGETRLRQILGNLLTNALDALAEKA- 512
Cdd:PRK13837 505 QILAFGRKGERNTKPFDLSELVTEIAPLL---RVSLppGVELDFDQDQEPAVVEGNPAELQQVLMNLCSNAAQAMDGAGr 581

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489233585 513 ----PPRRLWVIASQDQHGVI-------LTLRDNGPGFSEDALAHAHEPFFTTKttAKGLGLGLAICDNLLRALGGRLEM 581
Cdd:PRK13837 582 vdisLSRAKLRAPKVLSHGVLppgryvlLRVSDTGAGIDEAVLPHIFEPFFTTR--AGGTGLGLATVHGIVSAHAGYIDV 659

                        250       260
                 ....*....|....*....|....*....
gi 489233585 582 GNHLEGGAVVRLHlLPGVPGVAAMPQEET 610
Cdd:PRK13837 660 QSTVGRGTRFDVY-LPPSSKVPVAPQAFF 687
PRK10364 PRK10364
two-component system sensor histidine kinase ZraS;
356-595 2.23e-20

two-component system sensor histidine kinase ZraS;


Pssm-ID: 236674 [Multi-domain]  Cd Length: 457  Bit Score: 94.47  E-value: 2.23e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489233585 356 REQAQRELMRAQDEVVQAGKLTALGTMSASISHELNQPLAAIRSYADNARvlldhQRTE---DARGNLEQISDLTTRMAS 432
Cdd:PRK10364 214 YRRYLRSRQLLQDEMKRKEKLVALGHLAAGVAHEIRNPLSSIKGLAKYFA-----ERAPaggEAHQLAQVMAKEADRLNR 288

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489233585 433 IIAHLKAYARGARRAPENVQLQPAIEDALSMLASRRRAMNVEL-LRDVPDAPLwVQAGETRLRQILGNLLTNALDALAEK 511
Cdd:PRK10364 289 VVSELLELVKPTHLALQAVDLNDLINHSLQLVSQDANSREIQLrFTANDTLPE-IQADPDRLTQVLLNLYLNAIQAIGQH 367

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489233585 512 ApprRLWVIASQDQHGVILTLRDNGPGFSEDALAHAHEPFFTTKTTakGLGLGLAICDNLLRALGGRLEMGNHLEGGAVV 591
Cdd:PRK10364 368 G---VISVTASESGAGVKISVTDSGKGIAADQLEAIFTPYFTTKAE--GTGLGLAVVHNIVEQHGGTIQVASQEGKGATF 442


                 ....
gi 489233585 592 RLHL 595
Cdd:PRK10364 443 TLWL 446
PRK13557 PRK13557
histidine kinase; Provisional
 366-612 1.24e-19

histidine kinase; Provisional


Pssm-ID: 237425 [Multi-domain]  Cd Length: 540  Bit Score: 92.43  E-value: 1.24e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489233585 366 AQDEVVQAGKLTALGTMSASISHELNQPLAAIRSYADNARVLLDHQRTEDAR--GNLEQISDLTTRMASIIAHLKAYARG 443
Cdd:PRK13557 150 AEDALRQAQKMEALGQLTGGIAHDFNNLLQVMSGYLDVIQAALSHPDADRGRmaRSVENIRAAAERAATLTQQLLAFARK 229

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489233585 444 ARRAPENVQLQPAIEdALSMLASRRRAMNVELLRDVPDApLW-VQAGETRLRQILGNLLTNALDALAEKAPPR---RLWV 519
Cdd:PRK13557 230 QRLEGRVLNLNGLVS-GMGELAERTLGDAVTIETDLAPD-LWnCRIDPTQAEVALLNVLINARDAMPEGGRVTirtRNVE 307

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489233585 520 IASQDQHG---------VILTLRDNGPGFSEDALAHAHEPFFTTKTTAKGLGLGLAICDNLLRALGGRLEMGNHLEGGAV 590
Cdd:PRK13557 308 IEDEDLAMyhglppgryVSIAVTDTGSGMPPEILARVMDPFFTTKEEGKGTGLGLSMVYGFAKQSGGAVRIYSEVGEGTT 387

                        250       260
                 ....*....|....*....|..
gi 489233585 591 VRLhLLPGVPGVAAMPQEETRA 612
Cdd:PRK13557 388 VRL-YFPASDQAENPEQEPKAR 408
HATPase_TmoS-FixL-DctS-like cd16920
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 493-595 2.31e-18

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhizobium meliloti FixL, and Rhodobacter capsulatus DctS; includes hybrid sensor histidine kinase similar to Pseudomonas mendocina TmoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs), such as Pseudomonas mendocina TmoS HK of the TmoS-TmoT TCS, which controls the expression of the toluene-4-monooxygenase pathway, Rhizobium meliloti FixL HK of the FixL-FixJ TCS, which regulates the expression of the genes related to nitrogen fixation in the root nodule in response to O(2) levels, and Rhodobacter capsulatus DctS of the DctS-DctR TCS, which controls synthesis of the high-affinity C4-dicarboxylate transport system. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and PAS sensor domain(s); many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.


Pssm-ID: 340397 [Multi-domain]  Cd Length: 104  Bit Score: 80.52  E-value: 2.31e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489233585 493 LRQILGNLLTNALDALAEKAPPRRLWVI--ASQDQHGVILTLRDNGPGFSEDALAHAHEPFFTTKttAKGLGLGLAICDN 570
Cdd:cd16920    1 IQQVLINLVRNGIEAMSEGGCERRELTIrtSPADDRAVTISVKDTGPGIAEEVAGQLFDPFYTTK--SEGLGMGLSICRS 78

                         90       100
                 ....*....|....*....|....*
gi 489233585 571 LLRALGGRLEMGNHLEGGAVVRLHL 595
Cdd:cd16920   79 IIEAHGGRLSVESPAGGGATFQFTL 103
CitA COG3290
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction ...
 388-595 1.06e-17

Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction mechanisms];


Pssm-ID: 442519 [Multi-domain]  Cd Length: 389  Bit Score: 85.29  E-value: 1.06e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489233585 388 HELNQPLAAIRSYADNARV--------------LLDHQRTEDARGNLEQISDlttrmasiiaHLKAYARGARRAPENVQL 453
Cdd:COG3290  177 ERLEEELEGVKELAEALRAqrhdfrnhlhtisgLLQLGEYDEALEYIDEISE----------ELQELIDSLLSRIGNPVL 246

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489233585 454 QPAIEDALSMLASRRRAMNVELLRDVPDAPLWVQAgetrLRQILGNLLTNALDALAE-KAPPRRLWVIASQDQHGVILTL 532
Cdd:COG3290  247 AALLLGKAARARERGIDLTIDIDSDLPDLPLSDTD----LVTILGNLLDNAIEAVEKlPEEERRVELSIRDDGDELVIEV 322

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 489233585 533 RDNGPGFSEDALAHAHEPFFTTKtTAKGLGLGLAICDNLLRALGGRLEMGNHLEGGAVVRLHL 595
Cdd:COG3290  323 EDSGPGIPEELLEKIFERGFSTK-LGEGRGLGLALVKQIVEKYGGTIEVESEEGEGTVFTVRL 384
PRK15347 PRK15347
two component system sensor kinase;
314-595 7.20e-17

two component system sensor kinase;


Pssm-ID: 237951 [Multi-domain]  Cd Length: 921  Bit Score: 84.69  E-value: 7.20e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489233585 314 RRHYLDRIA------LEA--EAKRQLEERVLERTRELENAnaqlqqevheREQAQRELMRAQDEVvqagkltalgtmsAS 385
Cdd:PRK15347 348 RLDELGSIAkaynqlLDTlnEQYDTLENKVAERTQALAEA----------KQRAEQANKRKSEHL-------------TT 404

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489233585 386 ISHELNQPLAAIRSyadnARVLLDH-QRTEDARGNLEQISDLTTRMASIIAHLKAYAR----GARRAPENVQLQPAIEDA 460
Cdd:PRK15347 405 ISHEIRTPLNGVLG----ALELLQNtPLTAEQMDLADTARQCTLSLLAIINNLLDFSRiesgQMTLSLEETALLPLLDQA 480

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489233585 461 lsMLASRRRAMNVEL-LRDV--PDAPLWVQAGETRLRQILGNLLTNALdalaeKAPP--RRLWVIASQDQHgVILTLRDN 535
Cdd:PRK15347 481 --MLTIQGPAQSKSLtLRTFvgAHVPLYLHLDSLRLRQILVNLLGNAV-----KFTEtgGIRLRVKRHEQQ-LCFTVEDT 552

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 489233585 536 GPGFSEDALAHAHEPFFTTKTTAKGLGLGLAICDNLLRALGGRLEMGNHLEGGAVVRLHL 595
Cdd:PRK15347 553 GCGIDIQQQQQIFTPFYQADTHSQGTGLGLTIASSLAKMMGGELTLFSTPGVGSCFSLVL 612
HATPase_NtrY-like cd16944
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 491-595 1.46e-16

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Azorhizobium caulinodans NtrY; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Azorhizobium caulinodans ORS571 NtrY of the NtrY-NtrX TCS, which is involved in nitrogen fixation and metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also have PAS sensor domains.


Pssm-ID: 340420 [Multi-domain]  Cd Length: 108  Bit Score: 75.65  E-value: 1.46e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489233585 491 TRLRQILGNLLTNALDALAEKAPPR---RLWVIASQDQHgVILTLRDNGPGFSEDALAHAHEPFFTTKttAKGLGLGLAI 567
Cdd:cd16944    3 TQISQVLTNILKNAAEAIEGRPSDVgevRIRVEADQDGR-IVLIVCDNGKGFPREMRHRATEPYVTTR--PKGTGLGLAI 79

                         90       100
                 ....*....|....*....|....*...
gi 489233585 568 CDNLLRALGGRLEMGNHLEGGAVVRLHL 595
Cdd:cd16944   80 VKKIMEEHGGRISLSNREAGGACIRIIL 107
PRK11466 PRK11466
hybrid sensory histidine kinase TorS; Provisional
 318-595 2.35e-16

hybrid sensory histidine kinase TorS; Provisional


Pssm-ID: 236914 [Multi-domain]  Cd Length: 914  Bit Score: 83.03  E-value: 2.35e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489233585 318 LDRIALEAEAKRQlEERVLERTRE-----LENANAQLQQEVHEREQAqrelmRAQDEVVQAGKLTALGTMSasisHELNQ 392
Cdd:PRK11466 388 LDTIGRLMDAFRS-NVHALNRHREqlaaqVKARTAELQELVIEHRQA-----RAEAEKASQAKSAFLAAMS----HEIRT 457

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489233585 393 PLAAIRSyadNARVLLDHQRTEDARGNLEQISDLTTRMASII------AHLKAYARGARRAPENVQLQPAIEDALSMLAS 466
Cdd:PRK11466 458 PLYGILG---TAQLLADNPALNAQRDDLRAITDSGESLLTILndildySAIEAGGKNVSVSDEPFEPRPLLESTLQLMSG 534

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489233585 467 RRRAMNVELLRDVPDA-PLWVQAGETRLRQILGNLLTNALdalaeKAPPRRLWVIAS--QDQHGVIlTLRDNGPGFSEDA 543
Cdd:PRK11466 535 RVKGRPIRLATDIADDlPTALMGDPRRIRQVITNLLSNAL-----RFTDEGSIVLRSrtDGEQWLV-EVEDSGCGIDPAK 608

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|..
gi 489233585 544 LAHAHEPFFTTKTTAKGLGLGLAICDNLLRALGGRLEMGNHLEGGAVVRLHL 595
Cdd:PRK11466 609 LAEIFQPFVQVSGKRGGTGLGLTISSRLAQAMGGELSATSTPEVGSCFCLRL 660
HATPase_AtoS-like cd16943
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 493-597 2.79e-16

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 AtoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Escherichia coli AtoS, an HK of the AtoS-AtoC TCS. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have accessory domains such as HAMP or PAS sensor domains or CBS-pair domains.


Pssm-ID: 340419 [Multi-domain]  Cd Length: 105  Bit Score: 74.77  E-value: 2.79e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489233585 493 LRQILGNLLTNALDALAEKApprRLWVIASQDQHGVILTLRDNGPGFSEDALAHAHEPFFTTKTTAKGLGLGLAICDNLL 572
Cdd:cd16943    4 LNQVLLNLLVNAAQAMEGRG---RITIRTWAHVDQVLIEVEDTGSGIDPEILGRIFDPFFTTKPVGEGTGLGLSLSYRII 80

                         90       100
                 ....*....|....*....|....*
gi 489233585 573 RALGGRLEMGNHLEGGAVVRLhLLP 597
Cdd:cd16943   81 QKHGGTIRVASVPGGGTRFTI-ILP 104
HATPase_CckA-like cd16919
Histidine kinase-like ATPase domain of two-component sensor hybrid histidine kinases, similar ...
 493-595 1.83e-15

Histidine kinase-like ATPase domain of two-component sensor hybrid histidine kinases, similar to Brucella abortus 2308 CckA; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinase (HKs) similar to Brucella abortus 2308 CckA, which is a component of an essential protein phosphorelay that regulates expression of genes required for growth, division, and intracellular survival; phosphoryl transfer initiates from the sensor kinase CckA and proceeds via the ChpT phosphotransferase to two regulatory substrates: the DNA-binding response regulator CtrA and the phospho-receiver protein CpdR. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), a REC signal receiver domain, and some contain PAS or PAS and GAF sensor domain(s).


Pssm-ID: 340396 [Multi-domain]  Cd Length: 116  Bit Score: 72.80  E-value: 1.83e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489233585 493 LRQILGNLLTNALDALAEKA----PPRRLWVIASQDQHG--------VILTLRDNGPGFSEDALAHAHEPFFTTKTTAKG 560
Cdd:cd16919    1 LELAILNLAVNARDAMPEGGrltiETSNQRVDADYALNYrdlipgnyVCLEVSDTGSGMPAEVLRRAFEPFFTTKEVGKG 80

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 489233585 561 LGLGLAICDNLLRALGGRLEMGNHLEGGAVVRLHL 595
Cdd:cd16919   81 TGLGLSMVYGFVKQSGGHLRIYSEPGVGTTVRIYL 115
nifL_nitrog TIGR02938
nitrogen fixation negative regulator NifL; NifL is a modulator of the nitrogen fixation ...
 356-588 3.88e-15

nitrogen fixation negative regulator NifL; NifL is a modulator of the nitrogen fixation positive regulator protein NifA, and is therefore a negative regulator. It binds NifA. NifA and NifL are encoded by adjacent genes. [Central intermediary metabolism, Nitrogen fixation, Regulatory functions, Protein interactions]


Pssm-ID: 131984 [Multi-domain]  Cd Length: 494  Bit Score: 78.41  E-value: 3.88e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489233585  356 REQAQRELMRA-QDEVVQAGKLTALG-TMSASIsHELNQPLAAIRSyadNARVLldhQRTEDARGNLEQISDLTTRMASI 433
Cdd:TIGR02938 252 REEQERARLSAlQALMAEEERLEAIReTLSAAI-HRLQGPMNLISA---AISVL---QRRGDDAGNPASAAMLQQALSAG 324

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489233585  434 IAHLKAYARGARRAPEN----VQLQPAIEDALSMLASRRRAMNVeLLRDVPDAPL-WVQAGETRLRQILGNLLTNALDAL 508
Cdd:TIGR02938 325 REHMEALRQVIPQSPQEivvpVNLNQILRDVITLSTPRLLAAGI-VVDWQPAATLpAILGRELQLRSLFKALVDNAIEAM 403

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489233585  509 AEKAPPRR-LWVIASQDQHGVILTLRDNGPGFSEDALAHAHEPFFTTK-TTAKGLGLGLAICDNLLRALGGRLEMGNHLE 586
Cdd:TIGR02938 404 NIKGWKRReLSITTALNGDLIVVSILDSGPGIPQDLRYKVFEPFFTTKgGSRKHIGMGLSVAQEIVADHGGIIDLDDDYS 483


                  ..
gi 489233585  587 GG 588
Cdd:TIGR02938 484 EG 485
HATPase_DpiB-CitA-like cd16915
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 496-590 2.23e-14

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 DpiB, DcuS, and Bacillus subtilis CitS, DctS, and YufL; This family includes histidine kinase-like ATPase domains of Escherichia coli K-12 DpiB and DcuS, and Bacillus subtilis CitS, DctS and MalK histidine kinases (HKs) all of which are two component transduction systems (TCSs). E. coli K-12 DpiB (also known as CitA) is the histidine kinase (HK) of DpiA-DpiB, a two-component signal transduction system (TCS) required for the expression of citrate-specific fermentation genes and genes involved in plasmid inheritance. E. coli K-12 DcuS (also known as YjdH) is the HK of DcuS-DcuR, a TCS that in the presence of the extracellular C4-dicarboxlates, activates the expression of the genes of anaerobic fumarate respiration and of aerobic C4-dicarboxylate uptake. CitS is the HK of Bacillus subtilis CitS-CitT, a TCS which regulates expression of CitM, the Mg-citrate transporter. Bacillus subtilis DctS forms a tripartite sensor unit (DctS/DctA/DctB) for sensing C4 dicarboxylates. Bacillus subtilis MalK (also known as YfuL) is the HK of MalK-MalR (YufL-YufM) a TCS which regulates the expression of the malate transporters MaeN (YufR) and YflS, and is essential for utilization of malate in minimal medium. Proteins having this DpiB-CitA-like HATPase domain generally have sensor domains such as Cache and PAS, and a histidine kinase A (HisKA)-like SpoOB-type, alpha-helical domain.


Pssm-ID: 340392 [Multi-domain]  Cd Length: 104  Bit Score: 69.24  E-value: 2.23e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489233585 496 ILGNLLTNALDALA-EKAPPRRLWVIASQDQHGVILTLRDNGPGFSEDALAHAHEPFFTTKTTaKGLGLGLAICDNLLRA 574
Cdd:cd16915    4 IVGNLIDNALDALAaTGAPNKQVEVFLRDEGDDLVIEVRDTGPGIAPELRDKVFERGVSTKGQ-GERGIGLALVRQSVER 82

                         90
                 ....*....|....*.
gi 489233585 575 LGGRLEMGNHLEGGAV 590
Cdd:cd16915   83 LGGSITVESEPGGGTT 98
dCache_1 pfam02743
Cache domain; Double cache domain 1 covers the last three strands from the membrane distal ...
 48-276 7.75e-14

Cache domain; Double cache domain 1 covers the last three strands from the membrane distal PAS-like domain, the first two strands of the membrane proximal domain, and the connecting elements between the two domains. This domain when present in chemoreceptors recognize several signals such as proteinogenic amino acids, GABA, Histamine and polyamines, decanoic acid, Autoinducer-2, purine derivatives, quaternary amines, citrate and taurine, among others. When associated with histidine kinases, it recognizes C3/C4-dicarboxylic acids, Spermine, guanosine and Autoinducer-2 (Mantilla et al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1 https://doi.org/10.1093/femsre/fuab043).


Pssm-ID: 460673 [Multi-domain]  Cd Length: 237  Bit Score: 71.60  E-value: 7.75e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489233585   48 EQLAEQNRQTLDLYVANLLGTLRRYEELPQILGGLPVLRQALQQPgdplLQKIANEALADIRRRTGADVIYLLQPDGTTQ 127
Cdd:pfam02743   5 EQAEEQLLSLAKQLAENIESYLDSLEEILELLASNPDLQDLLSAP----AEEELAKLESLLRSNPGISSIYLVDADGRVL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489233585  128 VASNWAQADSFvhRNFAFRPYYREAMQGR---LARFFGLGTTSIKRGYYFASAVK---EGSRIIGVLVVKVDLEHIERLW 201
Cdd:pfam02743  81 ASSDESPSYPG--LDVSERPWYKEALKGGggiIWVFSSPYPSSESGEPVLTIARPiydDDGEVIGVLVADLDLDTLQELL 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489233585  202 GNSP----EQLLVIDNYGVVILSSR-EDWRFHASRPLSAAERDEIHANIPYPVQDpkplRLQQSAWLSQSRTLPETGWTV 276
Cdd:pfam02743 159 SQIKlgegGYVFIVDSDGRILAHPLgKNLRSLLAPFLGKSLADALPGSGITEIAV----DLDGEDYLVAYAPIPGTGWTL 234
HATPase_CpxA-like cd16949
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 493-595 4.80e-13

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CpxA; This family includes the histidine kinase-like ATPase (HATPase) domains of two-component sensor histidine kinase (HKs) similar to Escherichia coli CpxA, HK of the CpxA-CpxR two-component regulatory system (TCS) which may function in acid stress and in cell wall stability. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a CpxA family periplasmic domain.


Pssm-ID: 340425 [Multi-domain]  Cd Length: 104  Bit Score: 65.42  E-value: 4.80e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489233585 493 LRQILGNLLTNALdalaeKAPPRRLWVIASQDQHGVILTLRDNGPGFSEDALAHAHEPFFTTKTT----AKGLGLGLAIC 568
Cdd:cd16949    1 LARALENVLRNAL-----RYSPSKILLDISQDGDQWTITITDDGPGVPEDQLEQIFLPFYRVDSArdreSGGTGLGLAIA 75

                         90       100
                 ....*....|....*....|....*..
gi 489233585 569 DNLLRALGGRLEMGNHLEGGAVVRLHL 595
Cdd:cd16949   76 ERAIEQHGGKIKASNRKPGGLRVRIWL 102
HATPase_BaeS-like cd16946
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 490-595 7.86e-13

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BaeS HK of the BaeS/BaeR two-component regulatory system (TCS), which responds to envelope stress. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensory domain.


Pssm-ID: 340422 [Multi-domain]  Cd Length: 109  Bit Score: 65.18  E-value: 7.86e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489233585 490 ETRLRQILGNLLTNALDALAEKApprRLWVIASQDQHGVILTLRDNGPGFSEDALAHAHEPFFTTKTT----AKGLGLGL 565
Cdd:cd16946    2 RDRLQQLFVNLLENSLRYTDTGG---KLRIRAAQTPQEVRLDVEDSAPGVSDDQLARLFERFYRVESSrnraSGGSGLGL 78

                         90       100       110
                 ....*....|....*....|....*....|
gi 489233585 566 AICDNLLRALGGRLEMGNHLEGGavVRLHL 595
Cdd:cd16946   79 AICHNIALAHGGTISAEHSPLGG--LRLVL 106
HATPase_EvgS-ArcB-TorS-like cd16922
Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid ...
 493-581 1.78e-12

Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid sensor histidine kinases, similar to Escherichia coli EvgS, ArcB, TorS, BarA, RcsC; This family contains the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinases (HKs), including the following Escherichia coli HKs: EvgS, a HK of the EvgS-EvgA two-component system (TCS) that confers acid resistance; ArcB, a HK of the ArcB-ArcA TCS that modulates the expression of numerous genes in response to respiratory growth conditions; TorS, a HK of the TorS-TorR TCS which is involved in the anaerobic utilization of trimethylamine-N-oxide; BarA, a HK of the BarA-UvrY TCS involved in the regulation of carbon metabolism; and RcsC, a HK of the RcsB-RcsC TCS which regulates the expression of the capsule operon and of the cell division gene ftsZ. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), with most having accessory sensor domain(s) such as GAF, PAS and CHASE; many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.


Pssm-ID: 340399 [Multi-domain]  Cd Length: 110  Bit Score: 64.05  E-value: 1.78e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489233585 493 LRQILGNLLTNALdalaeKAPPR-----RLWVIASQDQHGVI-LTLRDNGPGFSEDALAHAHEPFFTTKTTAK----GLG 562
Cdd:cd16922    1 LRQILLNLLGNAI-----KFTEEgevtlRVSLEEEEEDGVQLrFSVEDTGIGIPEEQQARLFEPFSQADSSTTrkygGTG 75

                         90
                 ....*....|....*....
gi 489233585 563 LGLAICDNLLRALGGRLEM 581
Cdd:cd16922   76 LGLAISKKLVELMGGDISV 94
PRK10549 PRK10549
two-component system sensor histidine kinase BaeS;
384-579 5.86e-12

two-component system sensor histidine kinase BaeS;


Pssm-ID: 182539 [Multi-domain]  Cd Length: 466  Bit Score: 68.12  E-value: 5.86e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489233585 384 ASISHELNQPLAAIR----SYADNARvlldhQRTEDARGNLEQISDLTTRMASIIAHLKAYARGA---RRAPenVQLQPA 456
Cdd:PRK10549 245 ADISHELRTPLAVLRgeleAIQDGVR-----KFTPESVASLQAEVGTLTKLVDDLHQLSLSDEGAlayRKTP--VDLVPL 317

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489233585 457 IEDALSMLASRRRAMNVELLRDVPD-APLWvqAGETRLRQILGNLLTNALDALAEkapPRRLWVIASQDQHGVILTLRDN 535
Cdd:PRK10549 318 LEVAGGAFRERFASRGLTLQLSLPDsATVF--GDPDRLMQLFNNLLENSLRYTDS---GGSLHISAEQRDKTLRLTFADS 392

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*...
gi 489233585 536 GPGFSEDALAHAHEPFFTTKTT----AKGLGLGLAICDNLLRALGGRL 579
Cdd:PRK10549 393 APGVSDEQLQKLFERFYRTEGSrnraSGGSGLGLAICLNIVEAHNGRI 440
PRK10337 PRK10337
sensor protein QseC; Provisional
 388-594 7.48e-12

sensor protein QseC; Provisional


Pssm-ID: 182388 [Multi-domain]  Cd Length: 449  Bit Score: 67.75  E-value: 7.48e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489233585 388 HELNQPLAAIRSYADNARVLLDH-QRTEDARGNLEQISDLTTRMAS---IIAHLKAYARGARRAPenVQLQPAIEDALSM 463
Cdd:PRK10337 246 HELRSPLAALKVQTEVAQLSDDDpQARKKALLQLHAGIDRATRLVDqllTLSRLDSLDNLQDVAE--IPLEDLLQSAVMD 323

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489233585 464 LASRRRAMNVELLRDVPDAPLWVQAGETRLRQILGNLLTNALdalaeKAPPRRLWVIASQDQHGviLTLRDNGPGFSEDA 543
Cdd:PRK10337 324 IYHTAQQAGIDVRLTLNAHPVIRTGQPLLLSLLVRNLLDNAI-----RYSPQGSVVDVTLNARN--FTVRDNGPGVTPEA 396

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|..
gi 489233585 544 LAHAHEPFFTTK-TTAKGLGLGLAICDNLLRALGGRLEMGNHLEGGAVVRLH 594
Cdd:PRK10337 397 LARIGERFYRPPgQEATGSGLGLSIVRRIAKLHGMNVSFGNAPEGGFEAKVS 448
envZ PRK09467
osmolarity sensor protein; Provisional
 382-595 1.25e-11

osmolarity sensor protein; Provisional


Pssm-ID: 236531 [Multi-domain]  Cd Length: 435  Bit Score: 66.86  E-value: 1.25e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489233585 382 MSASISHELNQPLAAIRSyadnARVLLDHQRTEDARGNLEQISDlttrMASIIAHLKAYARGARRAP-ENVQLQPAIEDA 460
Cdd:PRK09467 232 LMAGVSHDLRTPLTRIRL----ATEMMSEEDGYLAESINKDIEE----CNAIIEQFIDYLRTGQEMPmEMADLNALLGEV 303

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489233585 461 LSMLASRRRAMNVELlrdvPDAPLWVQAGETRLRQILGNLLTNALdalaekapprRL---WVIAS--QDQHGVILTLRDN 535
Cdd:PRK09467 304 IAAESGYEREIETAL----QPGPIEVPMNPIAIKRALANLVVNAA----------RYgngWIKVSsgTEGKRAWFQVEDD 369

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 489233585 536 GPGFSEDALAHAHEPFfTTKTTAK---GLGLGLAICDNLLRALGGRLEMGNHLEGGAVVRLHL 595
Cdd:PRK09467 370 GPGIPPEQLKHLFQPF-TRGDSARgssGTGLGLAIVKRIVDQHNGKVELGNSEEGGLSARAWL 431
HATPase_EnvZ-like cd16950
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 493-595 3.51e-11

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli EnvZ and Pseudomonas aeruginosa BfmS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli EnvZ of the EnvZ-OmpR two-component regulatory system (TCS), which functions in osmoregulation. It also contains the HATPase domain of Pseudomonas aeruginosa BfmS, the HK of the BfmSR TCS, which functions in the regulation of the rhl quorum-sensing system and bacterial virulence in P. aeruginosa. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a periplasmic domain.


Pssm-ID: 340426 [Multi-domain]  Cd Length: 101  Bit Score: 60.16  E-value: 3.51e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489233585 493 LRQILGNLLTNALDAlaekappRRLWV-IASQ-DQHGVILTLRDNGPGFSEDALAHAHEPFFTTKT--TAKGLGLGLAIC 568
Cdd:cd16950    1 LKRVLSNLVDNALRY-------GGGWVeVSSDgEGNRTRIQVLDNGPGIAPEEVDELFQPFYRGDNarGTSGTGLGLAIV 73

                         90       100
                 ....*....|....*....|....*..
gi 489233585 569 DNLLRALGGRLEMGNHLEGGAVVRLHL 595
Cdd:cd16950   74 QRISDAHGGSLTLANRAGGGLCARIEL 100
HATPase_SpaK_NisK-like cd16975
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 490-593 1.18e-10

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK. SpaK is the histidine kinase (HK) of the SpaK-SpaR two-component regulatory system (TCS), which is involved in the regulation of the biosynthesis of lantibiotic subtilin. NisK is the HK of the NisK-NisR TCS, which is involved in the regulation of the biosynthesis of lantibiotic nisin. SpaK and NisK may function as membrane-associated protein kinases that phosphorylate SpaR and NisR, respectively, in response to environmental signals.


Pssm-ID: 340434 [Multi-domain]  Cd Length: 107  Bit Score: 58.63  E-value: 1.18e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489233585 490 ETRLRQILGNLLTNALDALAEKappRRLWVIASQDQHGVILTLRDNGPGFSEDALAHAHEPFFTTKT--TAKG-LGLGLA 566
Cdd:cd16975    2 TLLLSRALINIISNACQYAPEG---GTVSISIYDEEEYLYFEIWDNGHGFSEQDLKKALELFYRDDTsrRSGGhYGMGLY 78

                         90       100
                 ....*....|....*....|....*..
gi 489233585 567 ICDNLLRALGGRLEMGNHLEGGAVVRL 593
Cdd:cd16975   79 IAKNLVEKHGGSLIIENSQKGGAEVTV 105
HATPase_PhoQ-like cd16954
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 455-592 2.11e-10

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG. PhoQ is the histidine kinase (HK) of the PhoP-PhoQ two-component regulatory system (TCS), which responds to the levels of Mg2+ and Ca2+, controls virulence, mediates the adaptation to Mg2+-limiting environments, and regulates numerous cellular activities. Providencia stuartii AarG is a putative sensor kinase which controls the expression of the 2'-N-acetyltransferase and an intrinsic multiple antibiotic resistance (Mar) response in Providencia stuartii. The AarG product is similar to PhoQ in that it is able to restore wild-type levels of resistance to a Salmonella typhimurium phoQ mutant. However, the expression of the 2'-N-acetyltransferase gene and of aarP (a gene encoding a transcriptional activator of 2'-N-acetyltransferase) are not significantly affected by the levels of Mg2+ or Ca2+. Most proteins in this group contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have an accessory HAMP sensor domain, and some have an intracellular membrane -interaction PhoQ sensor domain.


Pssm-ID: 340430 [Multi-domain]  Cd Length: 135  Bit Score: 58.80  E-value: 2.11e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489233585 455 PAIEDALSMLASRRRAMNVELLRDVPDAPLWVqaGETR-LRQILGNLLTNALdalaeKAPPRRLWVIASQDQHGVILTLR 533
Cdd:cd16954    1 PLLDSLCSALNKVYQRKGVSISLDISPELRFP--GERNdLMELLGNLLDNAC-----KWCLEFVEVTARQTDGGLHLIVD 73

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 489233585 534 DNGPGFSEDALAHAHEPFFTTKTTAKGLGLGLAICDNLLRALGGRLEMGNHLEGGAVVR 592
Cdd:cd16954   74 DDGPGVPESQRSKIFQRGQRLDEQRPGQGLGLAIAKEIVEQYGGELSLSDSPLGGARFE 132
HATPase_BasS-like cd16940
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 482-595 3.53e-10

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BasS HK of the BasS-BasR two-component regulatory system (TCS). Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some contain a HAMP sensory domain, while some an N-terminal two-component sensor kinase domain.


Pssm-ID: 340417 [Multi-domain]  Cd Length: 113  Bit Score: 57.42  E-value: 3.53e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489233585 482 APLWVQAGETRLRQILGNLLTNALDALAEKApprRLWVIASQDQHGVILtLRDNGPGFSEDALAHAHEPFF-TTKTTAKG 560
Cdd:cd16940    3 ADIQVQGDALLLFLLLRNLVDNAVRYSPQGS---RVEIKLSADDGAVIR-VEDNGPGIDEEELEALFERFYrSDGQNYGG 78

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 489233585 561 LGLGLAICDNLLRALGGRLEMGNHLEGGAVVRLHL 595
Cdd:cd16940   79 SGLGLSIVKRIVELHGGQIFLGNAQGGGLEAWVRL 113
HATPase_YcbM-like cd16947
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 472-584 7.33e-10

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis YcbM; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis YcbM, a HK of the two-component system YcbM-YcbL. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA).


Pssm-ID: 340423 [Multi-domain]  Cd Length: 125  Bit Score: 57.14  E-value: 7.33e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489233585 472 NVELlrDVPDAPLWVQAGETRLRQILGNLLTNALDALAEKappRRLWVIASQDQHGVILTLRDNGPGFSEDALAHAHEPF 551
Cdd:cd16947    2 QVEI--NIPDRPIYANANTEALQRILKNLISNAIKYGSDG---KFLGMTLREDEKHVYIDIWDKGKGISETEKDHVFERL 76

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 489233585 552 FTTKTTA----KGLGLGLAICDNLLRALGGRLEMGNH 584
Cdd:cd16947   77 YTLEDSRnsakQGNGLGLTITKRLAESMGGSIYVNSK 113
ComP COG4585
Signal transduction histidine kinase ComP [Signal transduction mechanisms];
327-595 8.08e-10

Signal transduction histidine kinase ComP [Signal transduction mechanisms];


Pssm-ID: 443642 [Multi-domain]  Cd Length: 252  Bit Score: 59.63  E-value: 8.08e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489233585 327 AKRQLEERVLERTRELENANAQLQqevhEREQAQRELmraQDEVVQAgkltalgtmsasishelnqpLAAIRSYADNARV 406
Cdd:COG4585   29 ARRAERAAELERELAARAEEAREE----ERRRIAREL---HDGVGQS--------------------LSAIKLQLEAARR 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489233585 407 LLDHQrTEDARGNLEQISDLTTRmasIIAHLKAYARGAR-RAPENVQLQPAIEDALSMLaSRRRAMNVELLRDVPDAPLW 485
Cdd:COG4585   82 LLDAD-PEAAREELEEIRELARE---ALAELRRLVRGLRpPALDDLGLAAALEELAERL-LRAAGIRVELDVDGDPDRLP 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489233585 486 VQAGETRLRqILGNLLTNALdalaeK-APPRRLWVIASQDQHGVILTLRDNGPGFSEDAlahahepffttkTTAKGLGL- 563
Cdd:COG4585  157 PEVELALYR-IVQEALTNAL-----KhAGATRVTVTLEVDDGELTLTVRDDGVGFDPEA------------APGGGLGLr 218

                        250       260       270
                 ....*....|....*....|....*....|..
gi 489233585 564 GLAicdNLLRALGGRLEMGNHLEGGAVVRLHL 595
Cdd:COG4585  219 GMR---ERAEALGGTLTIGSAPGGGTRVRATL 247
HATPase_CreC-like cd16945
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 493-588 1.01e-09

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CreC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli CreC of the CreC-CreB two-component regulatory system (TCS) involved in catabolic regulation. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and accessory sensory domain(s) such as HAMP, CACHE or PAS.


Pssm-ID: 340421 [Multi-domain]  Cd Length: 106  Bit Score: 55.93  E-value: 1.01e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489233585 493 LRQILGNLLTNALDAlaekAPPRRLWVIASQ-DQHGVILTLRDNGPGFSEDALAHAHEPFFT---TKTTAKGLGLGLAIC 568
Cdd:cd16945    5 LRQAINNLLDNAIDF----SPEGGLIALQLEaDTEGIELLVFDEGSGIPDYALNRVFERFYSlprPHSGQKSTGLGLAFV 80

                         90       100
                 ....*....|....*....|
gi 489233585 569 DNLLRALGGRLEMGNHLEGG 588
Cdd:cd16945   81 QEVAQLHGGRITLRNRPDGV 100
PRK10604 PRK10604
sensor protein RstB; Provisional
 386-595 3.92e-09

sensor protein RstB; Provisional


Pssm-ID: 236724 [Multi-domain]  Cd Length: 433  Bit Score: 59.23  E-value: 3.92e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489233585 386 ISHELNQPLAAIRsYadnaRVLLDHQRTEDARGNLEQisDLTtRMASIIAHLKAYARGARraPEnVQLQPAIEDALSMLA 465
Cdd:PRK10604 219 IAHELRTPLVRLR-Y----RLEMSDNLSAAESQALNR--DIG-QLEALIEELLTYARLDR--PQ-NELHLSEPDLPAWLS 287

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489233585 466 SR---RRAMN--VELLRDVPDAPLwVQAGETRL-RQILGNLLTNALdalaeKAPPRRLWVIASQDQHGVILTLRDNGPGF 539
Cdd:PRK10604 288 THladIQAVTpeKTVRLDTPHQGD-YGALDMRLmERVLDNLLNNAL-----RYAHSRVRVSLLLDGNQACLIVEDDGPGI 361

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 489233585 540 SEDALAHAHEPFF----TTKTTAKGLGLGLAICDNLLRALGGRLEMGNHLEGGAVVRLHL 595
Cdd:PRK10604 362 PPEERERVFEPFVrldpSRDRATGGCGLGLAIVHSIALAMGGSVNCDESELGGARFSFSW 421
HisKA cd00082
Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed ...
 376-442 1.56e-08

Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-autophosphorylation by the catalytic domain of the histidine kinase. They subsequently transfer the phosphoryl group to the Asp acceptor residue of a response regulator protein. Two-component signalling systems, consisting of a histidine protein kinase that senses a signal input and a response regulator that mediates the output, are ancient and evolutionarily conserved signaling mechanisms in prokaryotes and eukaryotes.


Pssm-ID: 119399 [Multi-domain]  Cd Length: 65  Bit Score: 51.44  E-value: 1.56e-08
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 489233585 376 LTALGTMSASISHELNQPLAAIRSYADNARvlLDHQRTEDARGNLEQISDLTTRMASIIAHLKAYAR 442
Cdd:cd00082    1 LQAKGEFLANVSHELRTPLTAIRGALELLE--EELLDDEEQREYLERIREEAERLLRLINDLLDLSR 65
PRK10755 PRK10755
two-component system sensor histidine kinase PmrB;
384-588 2.68e-08

two-component system sensor histidine kinase PmrB;


Pssm-ID: 236751 [Multi-domain]  Cd Length: 356  Bit Score: 56.13  E-value: 2.68e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489233585 384 ASISHELNQPLAAIRSYADnarvLLDHQRTEDARGNLEQISdlttRMASIIAHLKAYAR-GARRAPENVQ--------LQ 454
Cdd:PRK10755 142 ADVAHELRTPLAGIRLHLE----LLEKQHHIDVAPLIARLD----QMMHTVEQLLQLARaGQSFSSGHYQtvklledvIL 213

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489233585 455 PAIEDALSMLASRRramnVELLRDVPDAPLWVQAGETRLRQILGNLLTNAldalAEKAPP-RRLWVIASQDQHGVILTLR 533
Cdd:PRK10755 214 PSQDELSEMLEQRQ----QTLLLPESAADITVQGDATLLRLLLRNLVENA----HRYSPEgSTITIKLSQEDGGAVLAVE 285

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 489233585 534 DNGPGFSEDALAHAHEPFFTTKTTAKGLGLGLAICDNLLRALGGRLEMGNHLEGG 588
Cdd:PRK10755 286 DEGPGIDESKCGELSKAFVRMDSRYGGIGLGLSIVSRITQLHHGQFFLQNRQERS 340
PRK09959 PRK09959
acid-sensing system histidine kinase EvgS;
384-584 3.49e-08

acid-sensing system histidine kinase EvgS;


Pssm-ID: 182169 [Multi-domain]  Cd Length: 1197  Bit Score: 56.67  E-value: 3.49e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489233585  384 ASISHELNQPLAAIRSYAD--NARVLLDHQRtedargnLEQISDLTTRMASIIAHLKAYARGARRAPENVQLQPAIEDAL 461
Cdd:PRK09959  717 ATMSHEIRTPISSIMGFLEllSGSGLSKEQR-------VEAISLAYATGQSLLGLIGEILDVDKIESGNYQLQPQWVDIP 789

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489233585  462 SML-----------ASRRRAMNVEllRDVPDAPLwVQAGETRLRQILGNLLTNALDALAEKAPPRRLWVIASQDQHGVI- 529
Cdd:PRK09959  790 TLVqntchsfgaiaASKSIALSCS--STFPDHYL-VKIDPQAFKQVLSNLLSNALKFTTEGAVKITTSLGHIDDNHAVIk 866

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 489233585  530 LTLRDNGPGFSEDALAHAHEPFFTTKTTAK--GLGLGLAICDNLLRALGGRLEMGNH 584
Cdd:PRK09959  867 MTIMDSGSGLSQEEQQQLFKRYSQTSAGRQqtGSGLGLMICKELIKNMQGDLSLESH 923
HisKA pfam00512
His Kinase A (phospho-acceptor) domain; dimerization and phospho-acceptor domain of histidine ...
 378-442 6.07e-08

His Kinase A (phospho-acceptor) domain; dimerization and phospho-acceptor domain of histidine kinases.


Pssm-ID: 459839 [Multi-domain]  Cd Length: 66  Bit Score: 49.90  E-value: 6.07e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 489233585  378 ALGTMSASISHELNQPLAAIRSYADnarVLLDHQRTEDARGNLEQISDLTTRMASIIAHLKAYAR 442
Cdd:pfam00512   1 AKSEFLANLSHELRTPLTAIRGYLE---LLRDEKLDEEQREYLETILRSAERLLRLINDLLDLSR 62
PRK10490 PRK10490
sensor protein KdpD; Provisional
 453-600 1.81e-07

sensor protein KdpD; Provisional


Pssm-ID: 236701 [Multi-domain]  Cd Length: 895  Bit Score: 54.27  E-value: 1.81e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489233585 453 LQPAIEDALSMLAS--RRRAMNVELLRDVP----DAPLwvqagetrLRQILGNLLTNALDALAEKAPprrLWVIASQDQH 526
Cdd:PRK10490 741 LEEVVGSALQMLEPglSGHPINLSLPEPLTlihvDGPL--------FERVLINLLENAVKYAGAQAE---IGIDAHVEGE 809

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 489233585 527 GVILTLRDNGPGFSEDALAHAHEPFFT-TKTTA-KGLGLGLAICDNLLRALGGRLEMGNHLEGGAVVRLHL-LPGVP 600
Cdd:PRK10490 810 RLQLDVWDNGPGIPPGQEQLIFDKFARgNKESAiPGVGLGLAICRAIVEVHGGTIWAENRPEGGACFRVTLpLETPP 886
HisKA smart00388
His Kinase A (phosphoacceptor) domain; Dimerisation and phosphoacceptor domain of histidine ...
 378-442 2.44e-07

His Kinase A (phosphoacceptor) domain; Dimerisation and phosphoacceptor domain of histidine kinases.


Pssm-ID: 214644 [Multi-domain]  Cd Length: 66  Bit Score: 47.95  E-value: 2.44e-07
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 489233585   378 ALGTMSASISHELNQPLAAIRSYADnarVLLDHQRTEDARGNLEQISDLTTRMASIIAHLKAYAR 442
Cdd:smart00388   1 AKREFLANLSHELRTPLTAIRGYLE---LLLDTELSEEQREYLETILREAERLLRLINDLLDLSR 62
HATPase_Glnl-NtrB-like cd16918
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 493-580 3.16e-07

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli GlnL (synonyms NtrB and NRII); This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs), similar to Escherichia coli GlnL/NtrB/NRII HK of the two-component regulatory system (TCS) GlnL/GlnG (NtrB-NtrC, or NRII-NRI), which regulates the transcription of genes encoding metabolic enzymes and permeases in response to carbon and nitrogen status in E. coli and related bacteria. Also included in this family are Rhodobacter capsulatus NtrB, Azospirillum brasilense NtrB, Vibrio alginolyticus NtrB, Rhizobium leguminosarum biovar phaseoli NtrB, and Herbaspirillum seropedicae NtrB. Escherichia coli GlnL/NtrB/NRII is both a kinase and a phosphatase, catalyzing the phosphorylation and dephosphorylation of GlnG/NtrC/NRI. The kinase and phosphatase activities of GlnL/NtrB/NRII are regulated by the PII signal transduction protein, which on binding to GlnL/NtrB/NRII, inhibits the kinase activity of GlnL/NtrB/NRII and activates the GlnL/NtrB/NRII phosphatase activity. Proteins having this HATPase domain also have a histidine kinase dimerization and phosphoacceptor domain (HisKA); some also contain PAS sensor domain(s).


Pssm-ID: 340395 [Multi-domain]  Cd Length: 109  Bit Score: 48.94  E-value: 3.16e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489233585 493 LRQILGNLLTNALDALAEKAPPRRLwviASQDQHGVI-------LTLR----DNGPGFSEDALAHAHEPFFTTKttAKGL 561
Cdd:cd16918    1 LIQVFLNLVRNAAQALAGSGGEIIL---RTRTQRQVTlghprhrLALRvsviDNGPGIPPDLQDTIFYPMVSGR--ENGT 75

                         90
                 ....*....|....*....
gi 489233585 562 GLGLAICDNLLRALGGRLE 580
Cdd:cd16918   76 GLGLAIAQNIVSQHGGVIE 94
PRK11086 PRK11086
sensory histidine kinase DcuS; Provisional
 496-581 3.77e-07

sensory histidine kinase DcuS; Provisional


Pssm-ID: 236839 [Multi-domain]  Cd Length: 542  Bit Score: 52.99  E-value: 3.77e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489233585 496 ILGNLLTNALDALAEKapPRRLWVIASQDQHG-VILTLRDNGPGFSEDALAHAHEPFFTTKttAKGLGLGLAICDNLLRA 574
Cdd:PRK11086 437 ILGNLIENALEAVGGE--EGGEISVSLHYRNGwLHCEVSDDGPGIAPDEIDAIFDKGYSTK--GSNRGVGLYLVKQSVEN 512


                 ....*..
gi 489233585 575 LGGRLEM 581
Cdd:PRK11086 513 LGGSIAV 519
HATPase_FilI-like cd16921
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 493-589 4.17e-07

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Methanosaeta harundinacea FilI and some hybrid sensor histidine kinases; This family includes FilI, the histidine kinase (HK) component of FilI-FilRs, a two-component signal transduction system (TCS) of the methanogenic archaeon, Methanosaeta harundinacea, which is involved in regulating methanogenesis. The cytoplasmic HK core consists of a C-terminal HK-like ATPase domain (represented here) and a histidine kinase dimerization and phosphoacceptor domain (HisKA) domain, which, in FilI, are coupled to CHASE, HAMP, PAS, and GAF sensor domains. FilI-FilRs catalyzes the phosphotransfer between FilI (HK) and FilRs (FilR1 and FilR2, response regulators) of the TCS. TCSs are predicted to be of bacterial origin, and acquired by archaea by horizontal gene transfer. This model also includes related HATPase domains such as that of Synechocystis sp. PCC6803 phytochrome-like protein Cph1. Proteins having this HATPase domain and HisKA domain also have accessory sensor domains such as CHASE, GAF, HAMP and PAS; some are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.


Pssm-ID: 340398 [Multi-domain]  Cd Length: 105  Bit Score: 48.48  E-value: 4.17e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489233585 493 LRQILGNLLTNALDALAEKAPPRrLWVIASQDQHGVILTLRDNGPGFSEDAlahaHEPFFT------TKTTAKGLGLGLA 566
Cdd:cd16921    1 LGQVLTNLLGNAIKFRRPRRPPR-IEVGAEDVGEEWTFYVRDNGIGIDPEY----AEKVFGifqrlhSREEYEGTGVGLA 75

                         90       100
                 ....*....|....*....|...
gi 489233585 567 ICDNLLRALGGRLEMGNHLEGGA 589
Cdd:cd16921   76 IVRKIIERHGGRIWLESEPGEGT 98
HATPase_RstB-like cd16939
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 493-595 4.65e-07

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Salmonella typhimurium RstB; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Salmonella typhimurium RstB HK of the RstA-RstB two-component regulatory system (TCS), which regulates expression of the constituents participating in pyrimidine metabolism and iron acquisition, and may be required for regulation of Salmonella motility and invasion. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensor domain.


Pssm-ID: 340416 [Multi-domain]  Cd Length: 104  Bit Score: 48.58  E-value: 4.65e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489233585 493 LRQILGNLLTNALdalaeKAPPRRLWVIASQDQHGVILTLRDNGPGFSEDALAHAHEPFF----TTKTTAKGLGLGLAIC 568
Cdd:cd16939    1 MARALDNLLRNAL-----RYAHRTVRIALLVSGGRLTLIVEDDGPGIPAAARERVFEPFVrldpSRDRATGGFGLGLAIV 75

                         90       100
                 ....*....|....*....|....*..
gi 489233585 569 DNLLRALGGRLEMGNHLEGGAVVRLHL 595
Cdd:cd16939   76 HRVALWHGGHVECDDSELGGACFRLTW 102
PRK09303 PRK09303
histidine kinase;
342-578 5.50e-07

histidine kinase;


Pssm-ID: 236462 [Multi-domain]  Cd Length: 380  Bit Score: 52.26  E-value: 5.50e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489233585 342 LENANAQLQQEvheREQAQRELmRAQDEVVqagkltalgtmsASISHELNQPLAAIRSYADNARVLLDHQRTEDARGNLE 421
Cdd:PRK09303 130 LSDELFVLRQE---NETLLEQL-KFKDRVL------------AMLAHDLRTPLTAASLALETLELGQIDEDTELKPALIE 193

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489233585 422 QISDLTTR----MASIIAHLKAYARGARRA----PENVQLQPAIEDALSMLASRRRAMNVELLRDVP-DAPLwVQAGETR 492
Cdd:PRK09303 194 QLQDQARRqleeIERLITDLLEVGRTRWEAlrfnPQKLDLGSLCQEVILELEKRWLAKSLEIQTDIPsDLPS-VYADQER 272

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489233585 493 LRQILGNLLTNALdalaeKAPPR----RLWVIASQDQHgVILTLRDNGPGFSEDALAHAHEPFFTTK--TTAKGLGLGLA 566
Cdd:PRK09303 273 IRQVLLNLLDNAI-----KYTPEggtiTLSMLHRTTQK-VQVSICDTGPGIPEEEQERIFEDRVRLPrdEGTEGYGIGLS 346

                        250
                 ....*....|..
gi 489233585 567 ICDNLLRALGGR 578
Cdd:PRK09303 347 VCRRIVRVHYGQ 358
HATPase_UhpB-NarQ-NarX-like cd16917
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 493-595 2.26e-06

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli UhpB, NarQ and NarX, and Bacillus subtilis YdfH, YhcY and YfiJ; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Escherichia coli UhpB, a HK of the UhpB-UhpA TCS, NarQ and NarX, HKs of the NarQ-NarP and NarX-NarL TCSs, respectively, and Bacillus YdfH, YhcY and YfiJ HKs, of the YdfH-YdfI, YhcY-YhcZ and YfiJ-YfiK TCSs, respectively. In addition, it includes Bacillus YxjM, ComP, LiaS and DesK, HKs of the YxjM-YxjML, ComP-ComA, LiaS-LiaR, DesR-DesK TCSs, respectively. Proteins having this HATPase domain have a histidine kinase dimerization and phosphoacceptor domain; some have accessory domains such as GAF, HAMP, PAS and MASE sensor domains.


Pssm-ID: 340394 [Multi-domain]  Cd Length: 87  Bit Score: 46.01  E-value: 2.26e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489233585 493 LRQILGNLLTNALdalaEKAPPRRLWVIASQDQHGVILTLRDNGPGFSEDAlahahepffttktTAKGLGLGLAICDNLL 572
Cdd:cd16917    1 LYRIVQEALTNAL----KHAGASRVRVTLSYTADELTLTVVDDGVGFDGPA-------------PPGGGGFGLLGMRERA 63

                         90       100
                 ....*....|....*....|...
gi 489233585 573 RALGGRLEMGNHLEGGAVVRLHL 595
Cdd:cd16917   64 ELLGGTLTIGSRPGGGTRVTARL 86
COG3920 COG3920
Two-component sensor histidine kinase, HisKA and HATPase domains [Signal transduction ...
 133-595 2.27e-06

Two-component sensor histidine kinase, HisKA and HATPase domains [Signal transduction mechanisms];


Pssm-ID: 443125 [Multi-domain]  Cd Length: 495  Bit Score: 50.67  E-value: 2.27e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489233585 133 AQADSFVHRNFAFRPYYREAMQGRLARFFGLGTTSIKRGYYFASAVKEGSRIIGVLVVKVDLEHIERLWGNSPEQLLVID 212
Cdd:COG3920   27 AALLLALLALLLLALLLLALLLASALLALLALSAAALAAALAVALAAAVGAAAALLALLVLLLLLLLAAAALALALLLAA 106

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489233585 213 NYGVVILSSREDWRFHASRPLSAAERDEIHANIPYPVQDPKPLRLQQSAWLSQSRTLPETGWTVSIYAPRTLIERPVRSV 292
Cdd:COG3920  107 LAGLLLLAALLLLRLVALLAALALLALLLLLLLLLAILALAELAVALAELAAALLLLAEELAALRLAAAALLLLLAALLD 186

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489233585 293 LLIGGATLLALLLLLTLLTLSRRHYLDRIALEAEAKRQLEERVLERTRELEnanAQLQQEVHEREQAQRELMRAQDEVVQ 372
Cdd:COG3920  187 LGLALAALAAAALLALLLALELLLALLLLLLLLLALLLVLLAALLRLRAAV---LEELERRRRARGLGRLLLLLLLLLLL 263

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489233585 373 AGKLTALGTMSASISHELNQPLAAIRSYADNARVLL----------------------DHQRTEDARGNLEQISDlttRM 430
Cdd:COG3920  264 LRALLLLAAGIRLVITERKRAEEELEASLEEKELLLrelhhrvknnlqvvssllrlqaRRADDPEAREALEESQN---RI 340

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489233585 431 ASI-IAHLKAYARGARrapENVQLQPAIEDALSMLASRRRAMNVELLRDVPDAPLWVQAGeTRLRQILGNLLTNALDALA 509
Cdd:COG3920  341 QALaLVHELLYQSEDW---EGVDLRDYLRELLEPLRDSYGGRGIRIELDGPDVELPADAA-VPLGLILNELVTNALKHAF 416

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489233585 510 EKAPPRRLWVIASQDQHGVILTLRDNGPGFSEDALAHAHEpffttkttakglGLGLAICDNLLRALGGRLEMGNhlEGGA 589
Cdd:COG3920  417 LSGEGGRIRVSWRREDGRLRLTVSDNGVGLPEDVDPPARK------------GLGLRLIRALVRQLGGTLELDR--PEGT 482


                 ....*.
gi 489233585 590 VVRLHL 595
Cdd:COG3920  483 RVRITF 488
PRK10841 PRK10841
two-component system sensor histidine kinase RcsC;
480-580 4.42e-05

two-component system sensor histidine kinase RcsC;


Pssm-ID: 182772 [Multi-domain]  Cd Length: 924  Bit Score: 46.51  E-value: 4.42e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489233585 480 PDAPLWVQAGETRLRQILGNLLTNAldalaekapprrlwvIASQDQHGVILTL-----------RDNGPGFSEDALAHAH 548
Cdd:PRK10841 550 PDVPVALNGDPMRLQQVISNLLSNA---------------IKFTDTGCIVLHVrvdgdylsfrvRDTGVGIPAKEVVRLF 614

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 489233585 549 EPFFT----TKTTAKGLGLGLAICDNLLRALGGRLE 580
Cdd:PRK10841 615 DPFFQvgtgVQRNFQGTGLGLAICEKLINMMDGDIS 650
HATPase_EcPhoR-like cd16952
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 493-597 6.51e-05

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoR; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli or Vibrio cholera PhoR, the histidine kinase (HK) of PhoB-PhoR a two-component signal transduction system (TCS) involved in phosphate regulation. PhoR monitors extracellular inorganic phosphate (Pi) availability and PhoB, the response regulator, regulates transcription of genes of the phosphate regulon. PhoR is a bifunctional histidine autokinase/phospho-PhoB phosphatase; in phosphate deficiency, it autophosphorylates and Pi is transferred to PhoB, and when environmental Pi is abundant, it removes the phosphoryl group from phosphorylated PhoB. Other roles of PhoB-PhoR TCS have been described, including motility, biofilm formation, intestinal colonization, and virulence in V. cholera. E.coli PhoR and Bacillus subtilis PhoR (whose HATPase domain belongs to a different family) sense very different signals in each bacterium. In E. coli the PhoR signal comes from phosphate transport mediated by the PstSCAB2 phosphate transporter and the PhoU chaperone-like protein while in B. subtilis, the PhoR activation signal comes from wall teichoic acid (WTA) metabolism.


Pssm-ID: 340428 [Multi-domain]  Cd Length: 108  Bit Score: 42.57  E-value: 6.51e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489233585 493 LRQILGNLLTNALDALAEKAPPRRLWviaSQDQHGVILTLRDNGPGFSEDALAHAHEPFFTTKTT----AKGLGLGLAIC 568
Cdd:cd16952    1 LRSAFSNLVSNAVKYTPPSDTITVRW---SQEESGARLSVEDTGPGIPPEHIPRLTERFYRVDIErcrnTGGTGLGLAIV 77

                         90       100
                 ....*....|....*....|....*....
gi 489233585 569 DNLLRALGGRLEMGNHLEGGAVVRLHLLP 597
Cdd:cd16952   78 KHVMSRHDARLLIASELGKGSRFTCLFPS 106
HATPase_BceS-YxdK-YvcQ-like cd16948
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 493-571 9.13e-05

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis BceS, YxdK, and Bacillus thuringiensis YvcQ; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis BceS and Bacillus thuringiensis YvcQ, the HKs of the two-component regulatory system (TCSs) BceS-BceR and YvcQ-YvcP, repsectively, which are both involved in regulating bacitracin resistance. It also includes the HATPase domain of YxdK, the HK of YxdK-YxdJ TCS involved in sensing antimicrobial compounds.


Pssm-ID: 340424 [Multi-domain]  Cd Length: 109  Bit Score: 41.89  E-value: 9.13e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489233585 493 LRQILGNLLTNALDALAEKApprRLWVIASQDQHGVILTLRDNGPGFSEDALAHAHEPFFTTK-----TTAKGLGLGLA- 566
Cdd:cd16948    6 LSFIIGQIVSNALKYSKQGG---KIEIYSETNEQGVVLSIKDFGIGIPEEDLPRVFDKGFTGEngrnfQESTGMGLYLVk 82


                 ....*.
gi 489233585 567 -ICDNL 571
Cdd:cd16948   83 kLCDKL 88
HATPase_BvrS-ChvG-like cd16953
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 493-591 1.37e-04

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Brucella abortus BvrS and Sinorhizobium meliloti ChvG; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Brucella abortus BvrS of the BvrR-BvrS two-component regulatory system (TCS), which controls cell invasion and intracellular survival, as well as Sinorhizobium meliloti and Agrobacterium tumefaciens ChvG of the ChvI-ChvG TCS necessary for endosymbiosis and pathogenicity in plants. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), an accessory HAMP sensor domain, a periplasmic stimulus-sensing domain, and some also have a sensor N-terminal transmembrane domain.


Pssm-ID: 340429 [Multi-domain]  Cd Length: 110  Bit Score: 41.40  E-value: 1.37e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489233585 493 LRQILGNLLTNALDAlaekAPPR--RLWVIASQDQHGVILTLRDNGPGFSEDALAHAHEPFFTTKTTAKGL----GLGLA 566
Cdd:cd16953    1 LGQVLRNLIGNAISF----SPPDtgRITVSAMPTGKMVTISVEDEGPGIPQEKLESIFDRFYTERPANEAFgqhsGLGLS 76

                         90       100
                 ....*....|....*....|....*
gi 489233585 567 ICDNLLRALGGRLEMGNHLEGGAVV 591
Cdd:cd16953   77 ISRQIIEAHGGISVAENHNQPGQVI 101
phoR PRK11006
phosphate regulon sensor histidine kinase PhoR;
363-580 1.84e-04

phosphate regulon sensor histidine kinase PhoR;


Pssm-ID: 182895 [Multi-domain]  Cd Length: 430  Bit Score: 44.23  E-value: 1.84e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489233585 363 LMRAQDeVVQAGKLT-ALGTMSASISHELNQPLAAIRSYadnarvlLDHQRTEDARGNLEQ-----ISDLTTRMASIIAH 436
Cdd:PRK11006 188 LMVARD-VTQMHQLEgARRNFFANVSHELRTPLTVLQGY-------LEMMQDQPLEGALREkalhtMREQTQRMEGLVKQ 259

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489233585 437 LKAYARgarrapenVQLQPAIE-----DALSMLASRRRAM------NVELLRDVpDAPLWVQAGETRLRQILGNLLTNAL 505
Cdd:PRK11006 260 LLTLSK--------IEAAPTIDlnekvDVPMMLRVLEREAqtlsqgKHTITFEV-DNSLKVFGNEDQLRSAISNLVYNAV 330

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489233585 506 DALAEKAPPRRLWviaSQDQHGVILTLRDNGPGFSEDALAHAHEPFFT-----TKTTAkGLGLGLAICDNLLRALGGRLE 580
Cdd:PRK11006 331 NHTPEGTHITVRW---QRVPQGAEFSVEDNGPGIAPEHIPRLTERFYRvdkarSRQTG-GSGLGLAIVKHALSHHDSRLE 406
YesM COG2972
Sensor histidine kinase YesM [Signal transduction mechanisms];
496-595 2.07e-04

Sensor histidine kinase YesM [Signal transduction mechanisms];


Pssm-ID: 442211 [Multi-domain]  Cd Length: 445  Bit Score: 44.24  E-value: 2.07e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489233585 496 ILGNLLTNALD-ALAEKAPPRRLWVIASQDQHGVILTLRDNGPGFSEDALAHAHEPFfttKTTAKGLGLGLAICDNLLRA 574
Cdd:COG2972  340 ILQPLVENAIEhGIEPKEGGGTIRISIRKEGDRLVITVEDNGVGMPEEKLEKLLEEL---SSKGEGRGIGLRNVRERLKL 416

                         90       100
                 ....*....|....*....|....
gi 489233585 575 L---GGRLEMGNHLEGGAVVRLHL 595
Cdd:COG2972  417 YygeEYGLEIESEPGEGTTVTIRI 440
PDC1_DGC_like cd12914
first PDC (PhoQ/DcuS/CitA) domain of diguanylate-cyclase and similar domains; Members of this ...
 84-194 4.65e-04

first PDC (PhoQ/DcuS/CitA) domain of diguanylate-cyclase and similar domains; Members of this subfamily display varying domain architectures but all contain double PDC (PhoQ/DcuS/CitA) sensor domains. This model represents the first PDC domain of Diguanylate-cyclases (DGCs), Histidine kinases (HKs), and other similar domains. Many members of this subfamily contain a C-terminal DGC (also called GGDEF) domain. DGCs regulate the turnover of cyclic diguanosine monophosphate. HK receptors are part of two-component systems (TCS) in bacteria that play a critical role for sensing and adapting to environmental changes. Typically, HK receptors contain an extracellular sensing domain flanked by two transmembrane helices, an intracellular dimerization histidine phosphorylation domain (DHp), and a C-terminal kinase domain, with many variations on this theme. In the case of HKs, signals detected by the sensor domain are transmitted through DHp to the kinase domain, resulting in the phosphorylation of a conserved histidine residue in DHp; phosphotransfer to a conserved aspartate in its cognate response regulator (RR) follows, which leads to the activation of genes for downstream cellular responses.


Pssm-ID: 350339  Cd Length: 123  Bit Score: 40.45  E-value: 4.65e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489233585  84 VLRQALQQPGDPLLQKIANEALADIRRRT-GADVIYLLQPDGTTQVASNwaqADSFVHRNFAFRPYYREAMQGRLARFFG 162
Cdd:cd12914   11 LADDLEARGAASADPAALQALLRRLLARLpEVRSIFVVDADGRVVASSG---PGPAPGLDVSDRDYFQAARAGGGGLFIS 87

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 489233585 163 ---LGTTSIKRGYYFASAVK-EGSRIIGVLVVKVDL 194
Cdd:cd12914   88 epvISRVTGKPVIPLSRPIRdADGRFAGVVVASIDL 123
HATPase_c_5 pfam14501
GHKL domain; This family represents the structurally related ATPase domains of histidine ...
 496-580 2.48e-03

GHKL domain; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.


Pssm-ID: 433996 [Multi-domain]  Cd Length: 102  Bit Score: 37.58  E-value: 2.48e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489233585  496 ILGNLLTNALDAlAEKAP-PRRLWVIASQDQHGVILTLrDNgpGFSEDALAHAHepFFTTKTTAKGLGLGLAICDNLLRA 574
Cdd:pfam14501   9 IFGNLLDNAIEA-CSKIDdNRFIRLKIREKQNFLIIRI-EN--TYEGELKFEGK--LPSTKTKGDGHGIGLKSIRRIVKK 82


                  ....*.
gi 489233585  575 LGGRLE 580
Cdd:pfam14501  83 YGGNLS 88
cpxA PRK09470
envelope stress sensor histidine kinase CpxA;
524-581 3.06e-03

envelope stress sensor histidine kinase CpxA;


Pssm-ID: 236532 [Multi-domain]  Cd Length: 461  Bit Score: 40.30  E-value: 3.06e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 489233585 524 DQHGVILTLRDNGPGFSEDALAHAHEPFFTTKTT----AKGLGLGLAICDNLLR-----------ALGG-RLEM 581
Cdd:PRK09470 380 DKDGLTITVDDDGPGVPEEEREQIFRPFYRVDEArdreSGGTGLGLAIVENAIQqhrgwvkaedsPLGGlRLTI 453
RsbW COG2172
Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms];
491-595 4.19e-03

Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms];


Pssm-ID: 441775 [Multi-domain]  Cd Length: 127  Bit Score: 37.59  E-value: 4.19e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489233585 491 TRLRQILGNLLTNALDALAEKAPPRRLWVIASQDQHGVILTLRDNGPGFSEDALAHAHEpffttktTAKGLGLGLAicdn 570
Cdd:COG2172   33 DDLVLAVSEAVTNAVRHAYGGDPDGPVEVELELDPDGLEIEVRDEGPGFDPEDLPDPYS-------TLAEGGRGLF---- 101

                         90       100
                 ....*....|....*....|....*
gi 489233585 571 LLRALGGRLEMgNHLEGGAVVRLHL 595
Cdd:COG2172  102 LIRRLMDEVEY-ESDPGGTTVRLVK 125
spIIAB TIGR01925
anti-sigma F factor; This model describes the SpoIIAB anti-sigma F factor. Sigma F regulates ...
 491-572 7.40e-03

anti-sigma F factor; This model describes the SpoIIAB anti-sigma F factor. Sigma F regulates spore development in B subtilis. SpoIIAB binds to sigma F, preventing formation of the transcription complex at the promoter. SpoIIAA (anti-anti-sigma F factor) binds to SpoIIAB to inhibit association with sigma F, however SpoIIAB can phosphorylate SpoIIAA, causing disassociation of the SpoIIAA/B complex. The SpoIIE phosphatase dephosphorylates SpoIIAA. [Regulatory functions, Protein interactions, Cellular processes, Sporulation and germination]


Pssm-ID: 130980 [Multi-domain]  Cd Length: 137  Bit Score: 37.21  E-value: 7.40e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489233585  491 TRLRQILGNLLTNALDALAEKAPPRRLWVIASQDQHGVILTLRDNGPGFSEdaLAHAHEPFFTTKTTAKGLGLGLAICDN 570
Cdd:TIGR01925  38 TDIKTAVSEAVTNAIIHGYEENCEGVVYISATIEDHEVYITVRDEGIGIEN--LEEAREPLYTSKPELERSGMGFTVMEN 115


                  ..
gi 489233585  571 LL 572
Cdd:TIGR01925 116 FM 117
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH