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Conserved domains on  [gi|489205952|ref|WP_003114985|]
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MULTISPECIES: two-component response regulator PprB [Pseudomonas]

Protein Classification

response regulator transcription factor( domain architecture ID 11468274)

response regulator transcription factor with a signal receiver (REC) domain and a LuxR family helix-turn-helix (HTH) domain that may be part of a two-component regulatory system; it receives the signal from the sensor partner, binds DNA upon phosphorylation, and functions as a transcriptional regulator

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
FixJ COG4566
DNA-binding response regulator, FixJ family, consists of REC and HTH domains [Signal ...
11-258 3.05e-26

DNA-binding response regulator, FixJ family, consists of REC and HTH domains [Signal transduction mechanisms, Transcription];


:

Pssm-ID: 443623 [Multi-domain]  Cd Length: 196  Bit Score: 101.72  E-value: 3.05e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489205952  11 VLIIDDEPQVTSELRELLENSGYRCVTSTHRESAIASFQADPnIGLVICDLYLGQDNGIRLIESLKEvagNGRFFESIIL 90
Cdd:COG4566    2 VYIVDDDEAVRDSLAFLLESAGLRVETFASAEAFLAALDPDR-PGCLLLDVRMPGMSGLELQEELAA---RGSPLPVIFL 77
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489205952  91 TGHDGRQEVIEAMRVGAADYYQKPVAPQELLHGLERLESRLHERVRSQLSLSHVNQRLEylaeslnsiyrdihkikyevh 170
Cdd:COG4566   78 TGHGDVPMAVRAMKAGAVDFLEKPFDDQALLDAVRRALARDRARRAERARRAELRARLA--------------------- 136
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489205952 171 gnsqpsalrsedsqpsappapvaesqvspsnplfgKLSPRQQAVARLVSKGLTNYQIAYELGITENTVKLYVSQVLRLMH 250
Cdd:COG4566  137 -----------------------------------SLTPREREVLDLVVAGLSNKQIARELGISPRTVEVHRANVMEKLG 181

                 ....*...
gi 489205952 251 MHNRTQLA 258
Cdd:COG4566  182 ARSLAELV 189
 
Name Accession Description Interval E-value
FixJ COG4566
DNA-binding response regulator, FixJ family, consists of REC and HTH domains [Signal ...
11-258 3.05e-26

DNA-binding response regulator, FixJ family, consists of REC and HTH domains [Signal transduction mechanisms, Transcription];


Pssm-ID: 443623 [Multi-domain]  Cd Length: 196  Bit Score: 101.72  E-value: 3.05e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489205952  11 VLIIDDEPQVTSELRELLENSGYRCVTSTHRESAIASFQADPnIGLVICDLYLGQDNGIRLIESLKEvagNGRFFESIIL 90
Cdd:COG4566    2 VYIVDDDEAVRDSLAFLLESAGLRVETFASAEAFLAALDPDR-PGCLLLDVRMPGMSGLELQEELAA---RGSPLPVIFL 77
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489205952  91 TGHDGRQEVIEAMRVGAADYYQKPVAPQELLHGLERLESRLHERVRSQLSLSHVNQRLEylaeslnsiyrdihkikyevh 170
Cdd:COG4566   78 TGHGDVPMAVRAMKAGAVDFLEKPFDDQALLDAVRRALARDRARRAERARRAELRARLA--------------------- 136
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489205952 171 gnsqpsalrsedsqpsappapvaesqvspsnplfgKLSPRQQAVARLVSKGLTNYQIAYELGITENTVKLYVSQVLRLMH 250
Cdd:COG4566  137 -----------------------------------SLTPREREVLDLVVAGLSNKQIARELGISPRTVEVHRANVMEKLG 181

                 ....*...
gi 489205952 251 MHNRTQLA 258
Cdd:COG4566  182 ARSLAELV 189
Response_reg pfam00072
Response regulator receiver domain; This domain receives the signal from the sensor partner in ...
11-122 2.55e-21

Response regulator receiver domain; This domain receives the signal from the sensor partner in bacterial two-component systems. It is usually found N-terminal to a DNA binding effector domain.


Pssm-ID: 395025 [Multi-domain]  Cd Length: 111  Bit Score: 86.05  E-value: 2.55e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489205952   11 VLIIDDEPQVTSELRELLENSGYRCVTSTHRESAIASFQADPnIGLVICDLYLGQDNGIRLIESLKEVAGNGRFfesIIL 90
Cdd:pfam00072   1 VLIVDDDPLIRELLRQLLEKEGYVVAEADDGKEALELLKEER-PDLILLDINMPGMDGLELLKRIRRRDPTTPV---IIL 76
                          90       100       110
                  ....*....|....*....|....*....|..
gi 489205952   91 TGHDGRQEVIEAMRVGAADYYQKPVAPQELLH 122
Cdd:pfam00072  77 TAHGDEDDAVEALEAGADDFLSKPFDPDELLA 108
REC cd00156
phosphoacceptor receiver (REC) domain of response regulators (RRs) and pseudo response ...
12-114 3.10e-21

phosphoacceptor receiver (REC) domain of response regulators (RRs) and pseudo response regulators (PRRs); Two-component systems (TCSs) involving a sensor and a response regulator are used by bacteria to adapt to changing environments. Processes regulated by two-component systems in bacteria include sporulation, pathogenicity, virulence, chemotaxis, and membrane transport. Response regulators (RRs) share the common phosphoacceptor REC domain and different effector/output domains such as DNA, RNA, ligand-binding, protein-binding, or enzymatic domains. Response regulators regulate transcription, post-transcription or post-translation, or have functions such as methylesterases, adenylate or diguanylate cyclase, c-di-GMP-specific phosphodiesterases, histidine kinases, serine/threonine protein kinases, and protein phosphatases, depending on their output domains. The function of some output domains are still unknown. TCSs are found in all three domains of life - bacteria, archaea, and eukaryotes, however, the presence and abundance of particular RRs vary between the lineages. Archaea encode very few RRs with DNA-binding output domains; most are stand-alone REC domains. Among eukaryotes, TCSs are found primarily in protozoa, fungi, algae, and green plants. REC domains function as phosphorylation-mediated switches within RRs, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381085 [Multi-domain]  Cd Length: 99  Bit Score: 85.74  E-value: 3.10e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489205952  12 LIIDDEPQVTSELRELLENSGYRCVTSTHRESAIASFQaDPNIGLVICDLYLGQDNGIRLIESLKEVAGNGRFfesIILT 91
Cdd:cd00156    1 LIVDDDPAIRELLKSLLEREGYEVDTAADGEEALELLR-EERPDLVLLDLMMPGMDGLELLRKLRELPPDIPV---IVLT 76
                         90       100
                 ....*....|....*....|...
gi 489205952  92 GHDGRQEVIEAMRVGAADYYQKP 114
Cdd:cd00156   77 AKADEEDAVRALELGADDYLVKP 99
PRK10651 PRK10651
transcriptional regulator NarL; Provisional
1-258 5.22e-18

transcriptional regulator NarL; Provisional


Pssm-ID: 182619 [Multi-domain]  Cd Length: 216  Bit Score: 80.07  E-value: 5.22e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489205952   1 MDKPASrhfsVLIIDDEPQVTSELRELLENSGYRCVT--STHRESAIA-SFQADPNigLVICDLYLGQDNGIRLIESLKE 77
Cdd:PRK10651   3 NQEPAT----ILLIDDHPMLRTGVKQLISMAPDITVVgeASNGEQGIElAESLDPD--LILLDLNMPGMNGLETLDKLRE 76
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489205952  78 VAGNGRFfesIILTGHDGRQEVIEAMRVGAADYYQKPVAPQELLhglerleSRLHERVRSQLSLShvnqrleylaESLNS 157
Cdd:PRK10651  77 KSLSGRI---VVFSVSNHEEDVVTALKRGADGYLLKDMEPEDLL-------KALQQAAAGEMVLS----------EALTP 136
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489205952 158 IYrdihkikyevhgnsqPSALRSEDsqpsaPPAPVAESQvspsnplfgkLSPRQQAVARLVSKGLTNYQIAYELGITENT 237
Cdd:PRK10651 137 VL---------------AASLRANR-----ATTERDVNQ----------LTPRERDILKLIAQGLPNKMIARRLDITEST 186
                        250       260
                 ....*....|....*....|.
gi 489205952 238 VKLYVSQVLRLMHMHNRTQLA 258
Cdd:PRK10651 187 VKVHVKHMLKKMKLKSRVEAA 207
HTH_LUXR smart00421
helix_turn_helix, Lux Regulon; lux regulon (activates the bioluminescence operon
207-258 2.50e-16

helix_turn_helix, Lux Regulon; lux regulon (activates the bioluminescence operon


Pssm-ID: 197715 [Multi-domain]  Cd Length: 58  Bit Score: 71.40  E-value: 2.50e-16
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 489205952   207 LSPRQQAVARLVSKGLTNYQIAYELGITENTVKLYVSQVLRLMHMHNRTQLA 258
Cdd:smart00421   4 LTPREREVLRLLAEGLTNKEIAERLGISEKTVKTHLSNIMRKLGVRSRTQAV 55
tetrathio_RR NF040749
tetrathionate respiration response regulator TtrR;
13-263 8.21e-11

tetrathionate respiration response regulator TtrR;


Pssm-ID: 468713 [Multi-domain]  Cd Length: 191  Bit Score: 59.68  E-value: 8.21e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489205952  13 IIDDEPQVTSELRELLENSGYRcVTSTHRESAiasFQADPNI---GLVICDLYLGQDNGIRLIESLKEvagNGRFFESII 89
Cdd:NF040749   4 LVDDDVAVTDACRFLLESLGYE-VQCWNDSEA---FLAQADLyqeGVVLLDMRMPGLDGHQVHQALRE---QGSTLAVVF 76
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489205952  90 LTGHDGRQEVIEAMRVGAADYYQKPVAPQELLHGLERlesrlhervrsqlSLSHVNQRLEYlaeslnsiyrdiHKIKyev 169
Cdd:NF040749  77 LTGHGDVPMAVEQMKLGAVDFLQKPVSAAPLQAALER-------------ALAVSAAAFER------------HQIR--- 128
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489205952 170 hgnsqpsaLRsedsqpsappapvaesqvspsnplFGKLSPRQQAVARLVSKGLTNYQIAYELGITENTVKLYVSQVLRLM 249
Cdd:NF040749 129 --------QR------------------------YQSLTPKEREIAGLVVQGLMNREIAEALNIAVRTVEVHRARVMEKM 176
                        250
                 ....*....|....
gi 489205952 250 HMHNRTQLALALSP 263
Cdd:NF040749 177 AAGSLAELVSQLQQ 190
PEP_resp_reg TIGR02915
PEP-CTERM-box response regulator transcription factor; Members of this protein family share ...
11-165 8.87e-11

PEP-CTERM-box response regulator transcription factor; Members of this protein family share full-length homology with (but do not include) the acetoacetate metabolism regulatory protein AtoC (see SP|Q06065). These proteins have a Fis family DNA binding sequence (pfam02954), a response regulator receiver domain (pfam00072), and sigma-54 interaction domain (pfam00158). [Regulatory functions, DNA interactions]


Pssm-ID: 274348 [Multi-domain]  Cd Length: 445  Bit Score: 61.69  E-value: 8.87e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489205952   11 VLIIDDEPQVTSELRELLEnsGYRCVTSTHRESAIASFQA-DPNIglVICDLYL-----GQDNGIRLIESLKEVAGNGRF 84
Cdd:TIGR02915   1 LLIVEDDLGLQKQLKWSFA--DYELAVAADRESAIALVRRhEPAV--VTLDLGLppdadGASEGLAALQQILAIAPDTKV 76
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489205952   85 fesIILTGHDGRQEVIEAMRVGAADYYQKPVAPQEL---------LHGLERlESRLHERVRSQLSLSHVNQRleylAESL 155
Cdd:TIGR02915  77 ---IVITGNDDRENAVKAIGLGAYDFYQKPIDPDVLklivdrafhLYTLET-ENRRLQSALGGTALRGLITS----SPGM 148
                         170
                  ....*....|
gi 489205952  156 NSIYRDIHKI 165
Cdd:TIGR02915 149 QKICRTIEKI 158
 
Name Accession Description Interval E-value
FixJ COG4566
DNA-binding response regulator, FixJ family, consists of REC and HTH domains [Signal ...
11-258 3.05e-26

DNA-binding response regulator, FixJ family, consists of REC and HTH domains [Signal transduction mechanisms, Transcription];


Pssm-ID: 443623 [Multi-domain]  Cd Length: 196  Bit Score: 101.72  E-value: 3.05e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489205952  11 VLIIDDEPQVTSELRELLENSGYRCVTSTHRESAIASFQADPnIGLVICDLYLGQDNGIRLIESLKEvagNGRFFESIIL 90
Cdd:COG4566    2 VYIVDDDEAVRDSLAFLLESAGLRVETFASAEAFLAALDPDR-PGCLLLDVRMPGMSGLELQEELAA---RGSPLPVIFL 77
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489205952  91 TGHDGRQEVIEAMRVGAADYYQKPVAPQELLHGLERLESRLHERVRSQLSLSHVNQRLEylaeslnsiyrdihkikyevh 170
Cdd:COG4566   78 TGHGDVPMAVRAMKAGAVDFLEKPFDDQALLDAVRRALARDRARRAERARRAELRARLA--------------------- 136
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489205952 171 gnsqpsalrsedsqpsappapvaesqvspsnplfgKLSPRQQAVARLVSKGLTNYQIAYELGITENTVKLYVSQVLRLMH 250
Cdd:COG4566  137 -----------------------------------SLTPREREVLDLVVAGLSNKQIARELGISPRTVEVHRANVMEKLG 181

                 ....*...
gi 489205952 251 MHNRTQLA 258
Cdd:COG4566  182 ARSLAELV 189
AtoC COG2204
DNA-binding transcriptional response regulator, NtrC family, contains REC, AAA-type ATPase, ...
10-153 2.55e-23

DNA-binding transcriptional response regulator, NtrC family, contains REC, AAA-type ATPase, and a Fis-type DNA-binding domains [Signal transduction mechanisms];


Pssm-ID: 441806 [Multi-domain]  Cd Length: 418  Bit Score: 98.11  E-value: 2.55e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489205952  10 SVLIIDDEPQVTSELRELLENSGYRCVTSTHRESAIASFQADPnIGLVICDLYLGQDNGIRLIESLKEVAGNGRFfesII 89
Cdd:COG2204    4 RILVVDDDPDIRRLLKELLERAGYEVETAASGEEALALLREEP-PDLVLLDLRMPGMDGLELLRELRALDPDLPV---IL 79
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 489205952  90 LTGHDGRQEVIEAMRVGAADYYQKPVAPQELLHGLERL--ESRLHERVRSQLSL---SHVNQRLEYLAE 153
Cdd:COG2204   80 LTGYGDVETAVEAIKAGAFDYLTKPFDLEELLAAVERAleRRRLRRENAEDSGLigrSPAMQEVRRLIE 148
Response_reg pfam00072
Response regulator receiver domain; This domain receives the signal from the sensor partner in ...
11-122 2.55e-21

Response regulator receiver domain; This domain receives the signal from the sensor partner in bacterial two-component systems. It is usually found N-terminal to a DNA binding effector domain.


Pssm-ID: 395025 [Multi-domain]  Cd Length: 111  Bit Score: 86.05  E-value: 2.55e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489205952   11 VLIIDDEPQVTSELRELLENSGYRCVTSTHRESAIASFQADPnIGLVICDLYLGQDNGIRLIESLKEVAGNGRFfesIIL 90
Cdd:pfam00072   1 VLIVDDDPLIRELLRQLLEKEGYVVAEADDGKEALELLKEER-PDLILLDINMPGMDGLELLKRIRRRDPTTPV---IIL 76
                          90       100       110
                  ....*....|....*....|....*....|..
gi 489205952   91 TGHDGRQEVIEAMRVGAADYYQKPVAPQELLH 122
Cdd:pfam00072  77 TAHGDEDDAVEALEAGADDFLSKPFDPDELLA 108
REC cd00156
phosphoacceptor receiver (REC) domain of response regulators (RRs) and pseudo response ...
12-114 3.10e-21

phosphoacceptor receiver (REC) domain of response regulators (RRs) and pseudo response regulators (PRRs); Two-component systems (TCSs) involving a sensor and a response regulator are used by bacteria to adapt to changing environments. Processes regulated by two-component systems in bacteria include sporulation, pathogenicity, virulence, chemotaxis, and membrane transport. Response regulators (RRs) share the common phosphoacceptor REC domain and different effector/output domains such as DNA, RNA, ligand-binding, protein-binding, or enzymatic domains. Response regulators regulate transcription, post-transcription or post-translation, or have functions such as methylesterases, adenylate or diguanylate cyclase, c-di-GMP-specific phosphodiesterases, histidine kinases, serine/threonine protein kinases, and protein phosphatases, depending on their output domains. The function of some output domains are still unknown. TCSs are found in all three domains of life - bacteria, archaea, and eukaryotes, however, the presence and abundance of particular RRs vary between the lineages. Archaea encode very few RRs with DNA-binding output domains; most are stand-alone REC domains. Among eukaryotes, TCSs are found primarily in protozoa, fungi, algae, and green plants. REC domains function as phosphorylation-mediated switches within RRs, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381085 [Multi-domain]  Cd Length: 99  Bit Score: 85.74  E-value: 3.10e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489205952  12 LIIDDEPQVTSELRELLENSGYRCVTSTHRESAIASFQaDPNIGLVICDLYLGQDNGIRLIESLKEVAGNGRFfesIILT 91
Cdd:cd00156    1 LIVDDDPAIRELLKSLLEREGYEVDTAADGEEALELLR-EERPDLVLLDLMMPGMDGLELLRKLRELPPDIPV---IVLT 76
                         90       100
                 ....*....|....*....|...
gi 489205952  92 GHDGRQEVIEAMRVGAADYYQKP 114
Cdd:cd00156   77 AKADEEDAVRALELGADDYLVKP 99
RpfG COG3437
Response regulator c-di-GMP phosphodiesterase, RpfG family, contains REC and HD-GYP domains ...
10-165 6.62e-21

Response regulator c-di-GMP phosphodiesterase, RpfG family, contains REC and HD-GYP domains [Signal transduction mechanisms];


Pssm-ID: 442663 [Multi-domain]  Cd Length: 224  Bit Score: 88.30  E-value: 6.62e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489205952  10 SVLIIDDEPQVTSELRELLENSGYRCVTSTHRESAIASFQADPnIGLVICDLYLGQDNGIRLIESLKEVAgNGRFFESII 89
Cdd:COG3437    8 TVLIVDDDPENLELLRQLLRTLGYDVVTAESGEEALELLLEAP-PDLILLDVRMPGMDGFELLRLLRADP-STRDIPVIF 85
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 489205952  90 LTGHDGRQEVIEAMRVGAADYYQKPVAPQELLhglerlesrlhERVRSQLSLSHVNQRLEYLAESL--NSIYRDIHKI 165
Cdd:COG3437   86 LTALADPEDRERALEAGADDYLTKPFDPEELL-----------ARVRNALELRRLQRELDDLVLYLklAAPLHDIGKI 152
CitB COG4565
DNA-binding response regulator DpiB of citrate/malate metabolism [Transcription, Signal ...
7-138 2.40e-19

DNA-binding response regulator DpiB of citrate/malate metabolism [Transcription, Signal transduction mechanisms];


Pssm-ID: 443622 [Multi-domain]  Cd Length: 138  Bit Score: 81.94  E-value: 2.40e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489205952   7 RHFSVLIIDDEPQVTSELRELLEN-SGYRCVTSTHR-ESAIASFQADPnIGLVICDLYLGQDNGIRLIESLKEVAGNGRF 84
Cdd:COG4565    2 KMIRVLIVEDDPMVAELLRRYLERlPGFEVVGVASSgEEALALLAEHR-PDLILLDIYLPDGDGLELLRELRARGPDVDV 80
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 489205952  85 fesIILTGHDGRQEVIEAMRVGAADYYQKPVAPQELLHGLERLESRLHERVRSQ 138
Cdd:COG4565   81 ---IVITAARDPETVREALRAGVVDYLIKPFTFERLREALERYLEYRRLLREDQ 131
OmpR COG0745
DNA-binding response regulator, OmpR family, contains REC and winged-helix (wHTH) domain ...
11-144 1.22e-18

DNA-binding response regulator, OmpR family, contains REC and winged-helix (wHTH) domain [Signal transduction mechanisms, Transcription];


Pssm-ID: 440508 [Multi-domain]  Cd Length: 204  Bit Score: 81.54  E-value: 1.22e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489205952  11 VLIIDDEPQVTSELRELLENSGYRCVTSTHRESAIASFQADPnIGLVICDLYLGQDNGIRLIESLKEVAGNGRFfesIIL 90
Cdd:COG0745    4 ILVVEDDPDIRELLADALEREGYEVDTAADGEEALELLEEER-PDLILLDLMLPGMDGLEVCRRLRARPSDIPI---IML 79
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 489205952  91 TGHDGRQEVIEAMRVGAADYYQKPVAPQELlhgLERLESRLHERVRSQLSLSHV 144
Cdd:COG0745   80 TARDDEEDRVRGLEAGADDYLTKPFDPEEL---LARIRALLRRRAAEVLRVGDL 130
PleD COG3706
Two-component response regulator, PleD family, consists of two REC domains and a diguanylate ...
10-122 3.13e-18

Two-component response regulator, PleD family, consists of two REC domains and a diguanylate cyclase (GGDEF) domain [Signal transduction mechanisms, Transcription];


Pssm-ID: 442920 [Multi-domain]  Cd Length: 179  Bit Score: 79.95  E-value: 3.13e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489205952  10 SVLIIDDEPQVTSELRELLENSGYRCVTSTHRESAIASFQADPnIGLVICDLYLGQDNGIRLIESLKEVAGnGRFFESII 89
Cdd:COG3706    3 RILVVDDDPTNRKLLRRLLEAAGYEVVEAADGEEALELLQEHR-PDLILLDLEMPDMDGLELCRRLRADPR-TADIPIIF 80
                         90       100       110
                 ....*....|....*....|....*....|...
gi 489205952  90 LTGHDGRQEVIEAMRVGAADYYQKPVAPQELLH 122
Cdd:COG3706   81 LTALDDEEDRARALEAGADDYLTKPFDPEELLA 113
REC_DctD-like cd17549
phosphoacceptor receiver (REC) domain of C4-dicarboxylic acid transport protein D (DctD) and ...
11-130 3.36e-18

phosphoacceptor receiver (REC) domain of C4-dicarboxylic acid transport protein D (DctD) and similar proteins; C4-dicarboxylic acid transport protein D (DctD) is part of the two-component regulatory system DctB/DctD, which regulates C4-dicarboxylate transport via regulation of expression of the dctPQM operon and dctA. It is an activator of sigma(54)-RNA polymerase holoenzyme that uses the energy released from ATP hydrolysis to stimulate the isomerization of a closed promoter complex to an open complex capable of initiating transcription. DctD is a member of the NtrC family, characterized by a domain architecture containing an N-terminal REC domain, followed by a central sigma-54 interaction/ATPase domain, and a C-terminal DNA binding domain. The ability of the central domain to hydrolyze ATP and thus to interact effectively with a complex of RNA polymerase, sigma54, and promoter, is controlled by the phosphorylation status of the REC domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381101 [Multi-domain]  Cd Length: 130  Bit Score: 78.30  E-value: 3.36e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489205952  11 VLIIDDEPQVTSELRELLENSGYRCVTSTHRESAIASFQADPNiGLVICDLYLGQDNGIRLIESLKEVAGNGRFfesIIL 90
Cdd:cd17549    1 VLLVDDDADVREALQQTLELAGFRVRAFADAEEALAALSPDFP-GVVISDIRMPGMDGLELLAQIRELDPDLPV---ILI 76
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 489205952  91 TGHDGRQEVIEAMRVGAADYYQKPVAPQELLHGLER-LESR 130
Cdd:cd17549   77 TGHGDVPMAVEAMRAGAYDFLEKPFDPERLLDVVRRaLEKR 117
PRK10651 PRK10651
transcriptional regulator NarL; Provisional
1-258 5.22e-18

transcriptional regulator NarL; Provisional


Pssm-ID: 182619 [Multi-domain]  Cd Length: 216  Bit Score: 80.07  E-value: 5.22e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489205952   1 MDKPASrhfsVLIIDDEPQVTSELRELLENSGYRCVT--STHRESAIA-SFQADPNigLVICDLYLGQDNGIRLIESLKE 77
Cdd:PRK10651   3 NQEPAT----ILLIDDHPMLRTGVKQLISMAPDITVVgeASNGEQGIElAESLDPD--LILLDLNMPGMNGLETLDKLRE 76
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489205952  78 VAGNGRFfesIILTGHDGRQEVIEAMRVGAADYYQKPVAPQELLhglerleSRLHERVRSQLSLShvnqrleylaESLNS 157
Cdd:PRK10651  77 KSLSGRI---VVFSVSNHEEDVVTALKRGADGYLLKDMEPEDLL-------KALQQAAAGEMVLS----------EALTP 136
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489205952 158 IYrdihkikyevhgnsqPSALRSEDsqpsaPPAPVAESQvspsnplfgkLSPRQQAVARLVSKGLTNYQIAYELGITENT 237
Cdd:PRK10651 137 VL---------------AASLRANR-----ATTERDVNQ----------LTPRERDILKLIAQGLPNKMIARRLDITEST 186
                        250       260
                 ....*....|....*....|.
gi 489205952 238 VKLYVSQVLRLMHMHNRTQLA 258
Cdd:PRK10651 187 VKVHVKHMLKKMKLKSRVEAA 207
CheY COG0784
CheY-like REC (receiver) domain, includes chemotaxis protein CheY and sporulation regulator ...
4-127 5.39e-18

CheY-like REC (receiver) domain, includes chemotaxis protein CheY and sporulation regulator Spo0F [Signal transduction mechanisms];


Pssm-ID: 440547 [Multi-domain]  Cd Length: 128  Bit Score: 77.97  E-value: 5.39e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489205952   4 PASRHFSVLIIDDEPQVTSELRELLENSGYRCVTSTHRESAIASFQADPnIGLVICDLYLGQDNGIRLIESLKEVAGNGR 83
Cdd:COG0784    1 PPLGGKRILVVDDNPDNRELLRRLLERLGYEVTTAEDGAEALELLRAGP-PDLILLDINMPGMDGLELLRRIRALPRLPD 79
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 489205952  84 --FfesIILTGHDGRQEVIEAMRVGAADYYQKPVAPQELLHGLERL 127
Cdd:COG0784   80 ipI---IALTAYADEEDRERALEAGADDYLTKPVDPEELLEALRRL 122
COG4567 COG4567
DNA-binding response regulator, ActR/RegA family, consists of REC and Fis-type HTH domains ...
10-172 2.69e-17

DNA-binding response regulator, ActR/RegA family, consists of REC and Fis-type HTH domains [Signal transduction mechanisms, Transcription];


Pssm-ID: 443624 [Multi-domain]  Cd Length: 177  Bit Score: 77.26  E-value: 2.69e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489205952  10 SVLIIDDEPQVTSELRELLENSGYRCVTSTHRESAIASFQADPnIGLVICDLYLGQDNGIRLIESLKEVAGNGRFfesII 89
Cdd:COG4567    6 SLLLVDDDEAFARVLARALERRGFEVTTAASVEEALALLEQAP-PDYAVLDLRLGDGSGLDLIEALRERDPDARI---VV 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489205952  90 LTGHDGRQEVIEAMRVGAADYYQKPVAPQELLHGLERLESRLHERVRSQLSLshvnQRLEYLAeslnsiyrdIHKIKYEV 169
Cdd:COG4567   82 LTGYASIATAVEAIKLGADDYLAKPADADDLLAALERAEGDAPAPPENPMSL----DRLEWEH---------IQRVLAEC 148

                 ...
gi 489205952 170 HGN 172
Cdd:COG4567  149 DGN 151
HTH_LUXR smart00421
helix_turn_helix, Lux Regulon; lux regulon (activates the bioluminescence operon
207-258 2.50e-16

helix_turn_helix, Lux Regulon; lux regulon (activates the bioluminescence operon


Pssm-ID: 197715 [Multi-domain]  Cd Length: 58  Bit Score: 71.40  E-value: 2.50e-16
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 489205952   207 LSPRQQAVARLVSKGLTNYQIAYELGITENTVKLYVSQVLRLMHMHNRTQLA 258
Cdd:smart00421   4 LTPREREVLRLLAEGLTNKEIAERLGISEKTVKTHLSNIMRKLGVRSRTQAV 55
REC_RegA-like cd17563
phosphoacceptor receiver (REC) domain of photosynthetic apparatus regulatory protein RegA; ...
10-124 8.91e-16

phosphoacceptor receiver (REC) domain of photosynthetic apparatus regulatory protein RegA; Rhodobacter sphaeroides RegA, also called response regulator PrrA, is the DNA binding regulatory protein of a redox-responsive two-component regulatory system RegB/RegA that is involved in transactivating anaerobic expression of the photosynthetic apparatus. It contains a REC domain and a DNA-binding helix-turn-helix output domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381111 [Multi-domain]  Cd Length: 112  Bit Score: 71.32  E-value: 8.91e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489205952  10 SVLIIDDEPQVTSELRELLENSGYRCVTSTHRESAIASFQADPnIGLVICDLYLGQDNGIRLIESLKEVAGNGRffeSII 89
Cdd:cd17563    2 SLLLVDDDEVFAERLARALERRGFEVETAHSVEEALALAREEK-PDYAVLDLRLGGDSGLDLIPPLRALQPDAR---IVV 77
                         90       100       110
                 ....*....|....*....|....*....|....*
gi 489205952  90 LTGHDGRQEVIEAMRVGAADYYQKPVAPQELLHGL 124
Cdd:cd17563   78 LTGYASIATAVEAIKLGADDYLAKPADADEILAAL 112
CitB COG2197
DNA-binding response regulator, NarL/FixJ family, contains REC and HTH domains [Signal ...
207-269 9.23e-16

DNA-binding response regulator, NarL/FixJ family, contains REC and HTH domains [Signal transduction mechanisms, Transcription];


Pssm-ID: 441799 [Multi-domain]  Cd Length: 131  Bit Score: 71.85  E-value: 9.23e-16
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 489205952 207 LSPRQQAVARLVSKGLTNYQIAYELGITENTVKLYVSQVLRLMHMHNRTQLALalspAAMQQG 269
Cdd:COG2197   70 LTPREREVLRLLAEGLSNKEIAERLGISERTVKTHVSNILRKLGVRNRTELVL----LALRLG 128
REC_RssB-like cd17555
phosphoacceptor receiver (REC) domain of Pseudomonas aeruginosa RssB and similar domains; ...
10-126 2.18e-15

phosphoacceptor receiver (REC) domain of Pseudomonas aeruginosa RssB and similar domains; Pseudomonas aeruginosa RssB is an orphan atypical response regulator containing a REC domain and a PP2C-type protein phosphatase output domain. Its function is still unknown. Escherichia RssB, which is not included in this subfamily, is a ClpX adaptor protein which alters ClpX specificity by mediating a specific interaction between ClpX and the substrates such as RpoS, an RNA polymerase sigma factor. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381107 [Multi-domain]  Cd Length: 116  Bit Score: 70.69  E-value: 2.18e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489205952  10 SVLIIDDEPQVTSELRELLENSGYRCVTSTHRESAIASFQAD-PNigLVICDLYLGQDNGIRLIESLKEVAGNgrfFESI 88
Cdd:cd17555    2 TILVIDDDEVVRESIAAYLEDSGFQVLQAADGRQGLELFRSEqPD--LVLCDLRMPEMDGLEVLKQITKESPD---TPVI 76
                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 489205952  89 ILTGHDGRQEVIEAMRVGAADYYQKPVAPQE-LLHGLER 126
Cdd:cd17555   77 VVSGAGVMSDAVEALRLGAWDYLTKPIEDLAvLEHAVRR 115
YesN COG4753
Two-component response regulator, YesN/AraC family, consists of REC and AraC-type DNA-binding ...
10-114 9.38e-15

Two-component response regulator, YesN/AraC family, consists of REC and AraC-type DNA-binding domains [Signal transduction mechanisms, Transcription];


Pssm-ID: 443786 [Multi-domain]  Cd Length: 103  Bit Score: 68.26  E-value: 9.38e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489205952  10 SVLIIDDEPQVTSELRELLE-NSGYRCV-TSTHRESAIASFQADPnIGLVICDLYLGQDNGIRLIESLKEVAGNGRFfes 87
Cdd:COG4753    1 KVLIVDDEPLIREGLKRILEwEAGFEVVgEAENGEEALELLEEHK-PDLVITDINMPGMDGLELLEAIRELDPDTKI--- 76
                         90       100
                 ....*....|....*....|....*..
gi 489205952  88 IILTGHDGRQEVIEAMRVGAADYYQKP 114
Cdd:COG4753   77 IILSGYSDFEYAQEAIKLGADDYLLKP 103
REC_NtrX-like cd17550
phosphoacceptor receiver (REC) domain of nitrogen assimilation regulatory protein NtrX and ...
11-126 5.64e-14

phosphoacceptor receiver (REC) domain of nitrogen assimilation regulatory protein NtrX and similar proteins; NtrX is part of the two-component regulatory system NtrY/NtrX that is involved in the activation of nitrogen assimilatory genes such as Gln. It is phosphorylated by the histidine kinase NtrY and interacts with sigma-54. NtrX is a member of the NtrC family, characterized by a domain architecture containing an N-terminal REC domain, followed by a central sigma-54 interaction/ATPase domain, and a C-terminal DNA binding domain. NtrC family response regulators are sigma54-dependent transcriptional activators. Also included in this subfamily is Aquifex aeolicus NtrC4. The ability of the central domain to hydrolyze ATP and thus to interact effectively with a complex of RNA polymerase, sigma54, and promoter, is controlled by the phosphorylation status of the REC domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381102 [Multi-domain]  Cd Length: 115  Bit Score: 66.75  E-value: 5.64e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489205952  11 VLIIDDEPQVTSELRELLENSGYRCVTSTHRESAIASFQAD-PNigLVICDLYLGQDNGIRLIESLKEvagNGRFFESII 89
Cdd:cd17550    1 ILIVDDEEDIRESLSGILEDEGYEVDTAADGEEALKLIKERrPD--LVLLDIWLPDMDGLELLKEIKE---KYPDLPVIM 75
                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 489205952  90 LTGHDGRQEVIEAMRVGAADYYQKPVAPQELLHGLER 126
Cdd:cd17550   76 ISGHGTIETAVKATKLGAYDFIEKPLSLDRLLLTIER 112
GerE pfam00196
Bacterial regulatory proteins, luxR family;
207-258 6.04e-14

Bacterial regulatory proteins, luxR family;


Pssm-ID: 425517 [Multi-domain]  Cd Length: 57  Bit Score: 64.91  E-value: 6.04e-14
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 489205952  207 LSPRQQAVARLVSKGLTNYQIAYELGITENTVKLYVSQVLRLMHMHNRTQLA 258
Cdd:pfam00196   3 LSPREREVLRWLAAGKSNKEIADELGISEKTVKVHRSNIMRKLNVHSRVELV 54
LytT COG3279
DNA-binding response regulator, LytR/AlgR family [Transcription, Signal transduction ...
11-172 6.05e-14

DNA-binding response regulator, LytR/AlgR family [Transcription, Signal transduction mechanisms];


Pssm-ID: 442510 [Multi-domain]  Cd Length: 235  Bit Score: 69.46  E-value: 6.05e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489205952  11 VLIIDDEPQVTSELRELLEN-SGYRCVTSTHR-ESAIASFQADPnIGLVICDLYLGQDNGIRLIESLKEVAGNGRFfesI 88
Cdd:COG3279    4 ILIVDDEPLARERLERLLEKyPDLEVVGEASNgEEALELLEEHK-PDLVFLDIQMPGLDGFELARQLRELDPPPPI---I 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489205952  89 ILTGHDgrQEVIEAMRVGAADYYQKPVAPQELLHGLERLESRLHERVRSQLSLSHvNQRLeyLAESLNSIYR-DIHKIKY 167
Cdd:COG3279   80 FTTAYD--EYALEAFEVNAVDYLLKPIDEERLAKALEKAKERLEAKAAAEASPEE-KDRI--FVKSGGKLVKiPLDDILY 154

                 ....*.
gi 489205952 168 -EVHGN 172
Cdd:COG3279  155 iEAEGN 160
fixJ PRK09390
response regulator FixJ; Provisional
11-262 6.31e-14

response regulator FixJ; Provisional


Pssm-ID: 181815 [Multi-domain]  Cd Length: 202  Bit Score: 68.88  E-value: 6.31e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489205952  11 VLIIDDEPQVTSELRELLENSGYRCVTsthRESAIASFQADPNI--GLVICDLYLGQDNGIRLIESLKEvagNGRFFESI 88
Cdd:PRK09390   6 VHVVDDDEAMRDSLAFLLDSAGFEVRL---FESAQAFLDALPGLrfGCVVTDVRMPGIDGIELLRRLKA---RGSPLPVI 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489205952  89 ILTGHDGRQEVIEAMRVGAADYYQKPVApqellhglerlESRLHERVRSQLSlshvnqrleylaeslnsiyrdihkikye 168
Cdd:PRK09390  80 VMTGHGDVPLAVEAMKLGAVDFIEKPFE-----------DERLIGAIERALA---------------------------- 120
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489205952 169 vhgnsqpsalrsedsqpSAPPAPVAESQVSPSNPLFGKLSPRQQAVARLVSKGLTNYQIAYELGITENTVKLYVSQVLRL 248
Cdd:PRK09390 121 -----------------QAPEAAKSEAVAADIRARIASLSERERQVMDGLVAGLSNKVIARDLDISPRTVEVYRANVMTK 183
                        250
                 ....*....|....*
gi 489205952 249 MHMHNRTQLA-LALS 262
Cdd:PRK09390 184 MQAGSLSELVrMALR 198
LuxR_C_like cd06170
C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix ...
207-258 8.25e-14

C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many are active as homodimers. Many are two domain proteins in which the DNA binding property of the C-terminal DNA binding domain is modulated by modifications of the N-terminal domain. For example in the case of Lux R which participates in the regulation of gene expression in response to fluctuations in cell-population density (quorum-sensing), a signaling molecule, the pheromone Acyl HSL (N-acyl derivatives of homoserine lactone), binds to the N-terminal domain and leads to LuxR dimerization. For others phophorylation of the N-terminal domain leads to multimerization, for example Escherichia coli NarL and Sinorhizobium melilot FixJ. NarL controls gene expression of many respiratory-related operons when environmental nitrate or nitrite is present under anerobic conditions. FixJ is involved in the transcriptional activation of nitrogen fixation genes. The group also includes small proteins which lack an N-terminal signaling domain, such as Bacillus subtilis GerE. GerE is dimeric and acts in conjunction with sigmaK as an activator or a repressor modulating the expression of various genes in particular those encoding the spore-coat. These LuxR family regulators may share a similar organization of their target binding sites. For example the LuxR dimer binds the lux box, a 20bp inverted repeat, GerE dimers bind two 12bp consensus sequences in inverted orientation having the central four bases overlap, and the NarL dimer binds two 7bp inverted repeats separated by 2 bp.


Pssm-ID: 99777 [Multi-domain]  Cd Length: 57  Bit Score: 64.48  E-value: 8.25e-14
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|..
gi 489205952 207 LSPRQQAVARLVSKGLTNYQIAYELGITENTVKLYVSQVLRLMHMHNRTQLA 258
Cdd:cd06170    1 LTPREREVLRLLAEGKTNKEIADILGISEKTVKTHLRNIMRKLGVKSRTQLV 52
REC_OmpR_PhoB cd17618
phosphoacceptor receiver (REC) domain of PhoB response regulator from the OmpR family; The ...
11-121 2.81e-12

phosphoacceptor receiver (REC) domain of PhoB response regulator from the OmpR family; The transcription factor PhoB is a component of the PhoR/PhoB two-component system, a key regulatory protein network that facilitates response to inorganic phosphate (Pi) starvation conditions by turning on the phosphate (pho) regulon whose products are involved in phosphorus uptake and metabolism. PhoB is a member of the OmpR family of DNA-binding response regulators that contains REC and winged helix-turn-helix (wHTH) DNA-binding output effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381133 [Multi-domain]  Cd Length: 118  Bit Score: 62.27  E-value: 2.81e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489205952  11 VLIIDDEPQVTSELRELLENSGYRCVTSTHRESAIaSFQADPNIGLVICDLYLGQDNGIRLIESLKEVAgNGRFFESIIL 90
Cdd:cd17618    3 ILIVEDEPAIREMIAFNLERAGFDVVEAEDAESAV-NLIVEPRPDLILLDWMLPGGSGIQFIRRLKRDE-MTRDIPIIML 80
                         90       100       110
                 ....*....|....*....|....*....|.
gi 489205952  91 TGHDGRQEVIEAMRVGAADYYQKPVAPQELL 121
Cdd:cd17618   81 TARGEEEDKVRGLEAGADDYITKPFSPRELV 111
GerE COG5905
Spore transcriptional regulator GerE (stand-alone HTH domain) [Cell cycle control, cell ...
207-261 3.57e-12

Spore transcriptional regulator GerE (stand-alone HTH domain) [Cell cycle control, cell division, chromosome partitioning, Transcription];


Pssm-ID: 444607 [Multi-domain]  Cd Length: 76  Bit Score: 60.74  E-value: 3.57e-12
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 489205952 207 LSPRQQAVARLVSKGLTNYQIAYELGITENTVKLYVSQVLRLMHMHNRTQLALAL 261
Cdd:COG5905   13 LTKREREVLELLAEGLTNKEIARQLFISEKTVKNHVSNILRKLGVRNRVQAVVWA 67
REC_OmpR_KdpE-like cd17620
phosphoacceptor receiver (REC) domain of KdpE-like OmpR family response regulators; KdpE is a ...
11-114 1.06e-11

phosphoacceptor receiver (REC) domain of KdpE-like OmpR family response regulators; KdpE is a component of the KdpD/KdpE two-component system (TCS) and is activated when histidine kinase KdpD senses a drop in external K+ concentration or upshift in ionic osmolarity, resulting in the expression of a heterooligomeric transporter KdpFABC. In addition, the KdpD/KdpE TCS is also an adaptive regulator involved in the virulence and intracellular survival of pathogenic bacteria. KdpE is a member of the OmpR family of DNA-binding response regulators that contain REC and winged helix-turn-helix (wHTH) DNA-binding output effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381135 [Multi-domain]  Cd Length: 99  Bit Score: 59.87  E-value: 1.06e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489205952  11 VLIIDDEPQVTSELRELLENSGYRCVTSTHRESAI---ASFQADpnigLVICDLYLGQDNGIRLIESLKE-----Vagng 82
Cdd:cd17620    1 ILVIEDEPQIRRFLRTALEAHGYRVFEAETGQEGLleaATRKPD----LIILDLGLPDMDGLEVIRRLREwsavpV---- 72
                         90       100       110
                 ....*....|....*....|....*....|..
gi 489205952  83 rffesIILTGHDGRQEVIEAMRVGAADYYQKP 114
Cdd:cd17620   73 -----IVLSARDEESDKIAALDAGADDYLTKP 99
REC_HupR-like cd17569
phosphoacceptor receiver (REC) domain of hydrogen uptake protein regulator (HupR) and similar ...
9-121 3.25e-11

phosphoacceptor receiver (REC) domain of hydrogen uptake protein regulator (HupR) and similar domains; This family is composed of mostly uncharacterized response regulators with similarity to the REC domains of response regulator components of two-component systems that regulates hydrogenase activity, including HupR and HoxA. HupR is part of the HupT/HupR system that controls the synthesis of the membrane-bound [NiFe]hydrogenase, HupSL, of the photosynthetic bacterium Rhodobacter capsulatus. It contains an N-terminal REC domain, a central sigma-54 interaction domain that lacks ATPase activity, and a C-terminal DNA-binding domain. Members of this family contain a REC domain and various output domains including the cyclase homology domain (CHD) and the c-di-GMP phosphodiesterase domains, HD-GYP and EAL. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381113 [Multi-domain]  Cd Length: 118  Bit Score: 59.34  E-value: 3.25e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489205952   9 FSVLIIDDEPQVTSELRELLENSGYRCVTSTHRESAIASFQADPnIGLVICDLYLGQDNGIRLIESLKEvagngRFFES- 87
Cdd:cd17569    1 PTILLVDDEPNILKALKRLLRREGYEVLTATSGEEALEILKQEP-VDVVISDQRMPGMDGAELLKRVRE-----RYPDTv 74
                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 489205952  88 -IILTGHDGRQEVIEAMRVGAADYY-QKPVAPQELL 121
Cdd:cd17569   75 rILLTGYADLDAAIEAINEGEIYRFlTKPWDDEELK 110
REC_NarL-like cd17535
phosphoacceptor receiver (REC) domain of NarL (Nitrate/Nitrite response regulator L) family ...
11-126 3.35e-11

phosphoacceptor receiver (REC) domain of NarL (Nitrate/Nitrite response regulator L) family response regulators; The NarL family is one of the more abundant families of DNA-binding response regulators (RRs). Members of the NarL family contain a REC domain and a helix-turn-helix (HTH) DNA-binding output domain, with a majority of members containing a LuxR-type HTH domain. They function as transcriptional regulators. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381090 [Multi-domain]  Cd Length: 117  Bit Score: 59.06  E-value: 3.35e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489205952  11 VLIIDDEPQVTSELRELLENSGYRCVTST--HRESAIASFQADPnIGLVICDLYLGQDNGIRLIESLKEVAGNGRFfesI 88
Cdd:cd17535    1 VLIVDDHPLVREGLRRLLESEPDIEVVGEaaDGEEALALLRELR-PDVVLMDLSMPGMDGIEALRRLRRRYPDLKV---I 76
                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 489205952  89 ILTGHDGRQEVIEAMRVGAADYYQKPVAPQELLHGLER 126
Cdd:cd17535   77 VLTAHDDPEYVLRALKAGAAGYLLKDSSPEELIEAIRA 114
REC_OmpR_EcPhoP-like cd19934
phosphoacceptor receiver (REC) domain of EcPhoP-like OmpR family response regulators; ...
11-130 4.07e-11

phosphoacceptor receiver (REC) domain of EcPhoP-like OmpR family response regulators; Escherichia coli PhoP (EcPhoP) is part of the PhoQ/PhoP two-component system (TCS) that regulates virulence genes and plays an essential role in the response of the bacteria to the environment of their mammalian hosts, sensing several stimuli such as extracellular magnesium limitation, low pH, the presence of cationic antimicrobial peptides, and osmotic upshift. This subfamily also includes Brucella suis FeuP, part of the FeuPQ TCS that is involved in the regulation of iron uptake, and Microchaete diplosiphon RcaC, which is required for chromatic adaptation. Members of this subfamily belong to the OmpR family of DNA-binding response regulators, which contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381161 [Multi-domain]  Cd Length: 117  Bit Score: 58.83  E-value: 4.07e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489205952  11 VLIIDDEPQVTSELRELLENSGYRCVTSTHRESAIasFQADP-NIGLVICDLYLGQDNGIRLIESLKEvagNGRFFESII 89
Cdd:cd19934    1 LLLVEDDALLAAQLKEQLSDAGYVVDVAEDGEEAL--FQGEEePYDLVVLDLGLPGMDGLSVLRRWRS---EGRATPVLI 75
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 489205952  90 LTGHDGRQEVIEAMRVGAADYYQKPVAPQELLHGLERLESR 130
Cdd:cd19934   76 LTARDSWQDKVEGLDAGADDYLTKPFHIEELLARLRALIRR 116
AmiR COG3707
Two-component response regulator, AmiR/NasT family, consists of REC and RNA-binding ...
7-149 4.30e-11

Two-component response regulator, AmiR/NasT family, consists of REC and RNA-binding antiterminator (ANTAR) domains [Signal transduction mechanisms, Transcription];


Pssm-ID: 442921 [Multi-domain]  Cd Length: 194  Bit Score: 60.74  E-value: 4.30e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489205952   7 RHFSVLIIDDEPQVTSELRELLENSGYRCVTSTHRESAIASFQADPNIGLVICDLYLGQDNGIRLIESLKEVAGNGrffe 86
Cdd:COG3707    2 RGLRVLVVDDEPLRRADLREGLREAGYEVVAEAADGEDAVELVRELKPDLVIVDIDMPDRDGLEAARQISEERPAP---- 77
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 489205952  87 SIILTGHDGRQEVIEAMRVGAADYYQKPVAPQELLHGLERLESRLHERVRSQLSLSHVNQRLE 149
Cdd:COG3707   78 VILLTAYSDPELIERALEAGVSAYLVKPLDPEDLLPALELALARFRELRALRRELAKLREALE 140
REC_CheY cd17542
phosphoacceptor receiver (REC) domain of chemotaxis protein CheY; The chemotaxis response ...
11-127 7.16e-11

phosphoacceptor receiver (REC) domain of chemotaxis protein CheY; The chemotaxis response regulator CheY contains a stand-alone REC domain. Chemotaxis is a behavior known for motile bacteria that directs their movement in response to chemical gradients. CheY is involved in transmitting sensory signals from chemoreceptors to the flagellar motors. Phosphorylated CheY interacts with the flagella switch components FliM and FliY, which causes counterclockwise rotation of the flagella, resulting in smooth swimming. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381097 [Multi-domain]  Cd Length: 117  Bit Score: 58.06  E-value: 7.16e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489205952  11 VLIIDDEPQVTSELRELLENSGYRCV-TSTHRESAIASFQA-DPNigLVICDLYLGQDNGIRLIESLKEVAGNGRffesI 88
Cdd:cd17542    3 VLIVDDAAFMRMMLKDILTKAGYEVVgEAANGEEAVEKYKElKPD--LVTMDITMPEMDGIEALKEIKKIDPNAK----V 76
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 489205952  89 ILTGHDGRQE-VIEAMRVGAADYYQKPVAPQELLHGLERL 127
Cdd:cd17542   77 IMCSAMGQEEmVKEAIKAGAKDFIVKPFQPERVLEAVEKV 116
tetrathio_RR NF040749
tetrathionate respiration response regulator TtrR;
13-263 8.21e-11

tetrathionate respiration response regulator TtrR;


Pssm-ID: 468713 [Multi-domain]  Cd Length: 191  Bit Score: 59.68  E-value: 8.21e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489205952  13 IIDDEPQVTSELRELLENSGYRcVTSTHRESAiasFQADPNI---GLVICDLYLGQDNGIRLIESLKEvagNGRFFESII 89
Cdd:NF040749   4 LVDDDVAVTDACRFLLESLGYE-VQCWNDSEA---FLAQADLyqeGVVLLDMRMPGLDGHQVHQALRE---QGSTLAVVF 76
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489205952  90 LTGHDGRQEVIEAMRVGAADYYQKPVAPQELLHGLERlesrlhervrsqlSLSHVNQRLEYlaeslnsiyrdiHKIKyev 169
Cdd:NF040749  77 LTGHGDVPMAVEQMKLGAVDFLQKPVSAAPLQAALER-------------ALAVSAAAFER------------HQIR--- 128
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489205952 170 hgnsqpsaLRsedsqpsappapvaesqvspsnplFGKLSPRQQAVARLVSKGLTNYQIAYELGITENTVKLYVSQVLRLM 249
Cdd:NF040749 129 --------QR------------------------YQSLTPKEREIAGLVVQGLMNREIAEALNIAVRTVEVHRARVMEKM 176
                        250
                 ....*....|....
gi 489205952 250 HMHNRTQLALALSP 263
Cdd:NF040749 177 AAGSLAELVSQLQQ 190
PEP_resp_reg TIGR02915
PEP-CTERM-box response regulator transcription factor; Members of this protein family share ...
11-165 8.87e-11

PEP-CTERM-box response regulator transcription factor; Members of this protein family share full-length homology with (but do not include) the acetoacetate metabolism regulatory protein AtoC (see SP|Q06065). These proteins have a Fis family DNA binding sequence (pfam02954), a response regulator receiver domain (pfam00072), and sigma-54 interaction domain (pfam00158). [Regulatory functions, DNA interactions]


Pssm-ID: 274348 [Multi-domain]  Cd Length: 445  Bit Score: 61.69  E-value: 8.87e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489205952   11 VLIIDDEPQVTSELRELLEnsGYRCVTSTHRESAIASFQA-DPNIglVICDLYL-----GQDNGIRLIESLKEVAGNGRF 84
Cdd:TIGR02915   1 LLIVEDDLGLQKQLKWSFA--DYELAVAADRESAIALVRRhEPAV--VTLDLGLppdadGASEGLAALQQILAIAPDTKV 76
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489205952   85 fesIILTGHDGRQEVIEAMRVGAADYYQKPVAPQEL---------LHGLERlESRLHERVRSQLSLSHVNQRleylAESL 155
Cdd:TIGR02915  77 ---IVITGNDDRENAVKAIGLGAYDFYQKPIDPDVLklivdrafhLYTLET-ENRRLQSALGGTALRGLITS----SPGM 148
                         170
                  ....*....|
gi 489205952  156 NSIYRDIHKI 165
Cdd:TIGR02915 149 QKICRTIEKI 158
REC_OmpR_ArcA_TorR-like cd17619
phosphoacceptor receiver (REC) domain of ArcA- and TorR-like OmpR family response regulators; ...
10-121 1.07e-10

phosphoacceptor receiver (REC) domain of ArcA- and TorR-like OmpR family response regulators; This subfamily includes Escherichia coli TorR and ArcA, both OmpR family response regulators that mediate adaptation to changes in various respiratory growth conditions. The TorS-TorR two-component system (TCS) is responsible for the tight regulation of the torCAD operon, which encodes the trimethylamine N-oxide (TMAO) reductase respiratory system in response to anaerobic conditions and the presence of TMAO. The ArcA-ArcB TCS is involved in cell growth during anaerobiosis. ArcA is a global regulator that controls more than 30 operons involved in redox regulation (the Arc modulon). OmpR family DNA-binding response regulators are characterized by a REC domain and a winged helix-turn-helix (wHTH) DNA-binding output effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381134 [Multi-domain]  Cd Length: 113  Bit Score: 57.78  E-value: 1.07e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489205952  10 SVLIIDDEPQVTSELRELLENSGYRCVTSTHRESAIASFQADPnIGLVICDLYLGQDNGIRLIESLKEVAGNGrffeSII 89
Cdd:cd17619    2 HILIVEDEPVTRATLKSYFEQEGYDVSEAGDGEEMRQILARQD-IDLVLLDINLPGKDGLSLTRELREQSEVG----IIL 76
                         90       100       110
                 ....*....|....*....|....*....|..
gi 489205952  90 LTGHDGRQEVIEAMRVGAADYYQKPVAPQELL 121
Cdd:cd17619   77 VTGRDDEVDRIVGLEIGADDYVTKPFNPRELL 108
REC_FixJ cd17537
phosphoacceptor receiver (REC) domain of FixJ family response regulators; FixJ family response ...
11-126 1.12e-10

phosphoacceptor receiver (REC) domain of FixJ family response regulators; FixJ family response regulators contain an N-terminal receiver domain (REC) and a C-terminal LuxR family helix-turn-helix (HTH) DNA-binding output domain. The Sinorhizobium meliloti two-component system FixL/FixJ regulates nitrogen fixation in response to oxygen during symbiosis. Under microaerobic conditions, the kinase FixL phosphorylates the response regulator FixJ resulting in the regulation of nitrogen fixation genes such as nifA and fixK. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381092 [Multi-domain]  Cd Length: 116  Bit Score: 57.60  E-value: 1.12e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489205952  11 VLIIDDEPQVTSELRELLENSGYRCVTSTHRESAIASFQADPNiGLVICDLYLGQDNGIRLIESLKEVagnGRFFESIIL 90
Cdd:cd17537    3 VYVVDDDEAVRDSLAFLLRSVGLAVKTFTSASAFLAAAPPDQP-GCLVLDVRMPGMSGLELQDELLAR---GSNIPIIFI 78
                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 489205952  91 TGHDGRQEVIEAMRVGAADYYQKPVAPQELLHGLER 126
Cdd:cd17537   79 TGHGDVPMAVEAMKAGAVDFLEKPFRDQVLLDAIEQ 114
REC_YesN-like cd17536
phosphoacceptor receiver (REC) domain of YesN and related helix-turn-helix containing response ...
11-131 1.22e-10

phosphoacceptor receiver (REC) domain of YesN and related helix-turn-helix containing response regulators; This family is composed of uncharacterized response regulators that contain a REC domain and a AraC family helix-turn-helix (HTH) DNA-binding output domain, including Bacillus subtilis uncharacterized transcriptional regulatory protein YesN and Staphylococcus aureus uncharacterized response regulatory protein SAR0214. YesN is a member of the two-component regulatory system YesM/YesN and SAR0214 is a member of the probable two-component regulatory system SAR0215/SAR0214. Also included in this family is the AlgR-like group of LytTR/AlgR family response, which includes Pseudomonas aeruginosa positive alginate biosynthesis regulatory protein AlgR and Bacillus subtilis sensory transduction protein LytT, among others. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381091 [Multi-domain]  Cd Length: 121  Bit Score: 57.73  E-value: 1.22e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489205952  11 VLIIDDEPQVTSELRELL--ENSGYRCV-TSTHRESA---IASFQADpnigLVICDLYLGQDNGIRLIESLKEVAGNGRF 84
Cdd:cd17536    1 VLIVDDEPLIREGLKKLIdwEELGFEVVgEAENGEEAlelIEEHKPD----IVITDIRMPGMDGLELIEKIRELYPDIKI 76
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 489205952  85 fesIILTGHDgrqE---VIEAMRVGAADYYQKPVAPQELLHGLERLESRL 131
Cdd:cd17536   77 ---IILSGYD---DfeyAQKAIRLGVVDYLLKPVDEEELEEALEKAKEEL 120
REC_OmpR cd17574
phosphoacceptor receiver (REC) domain of OmpR family response regulators; OmpR-like proteins ...
12-114 1.64e-10

phosphoacceptor receiver (REC) domain of OmpR family response regulators; OmpR-like proteins are one of the most widespread transcriptional regulators. OmpR family members contain REC and winged helix-turn-helix (wHTH) DNA-binding output effector domain. They are involved in the control of environmental stress tolerance (such as the oxidative, osmotic and acid stress response), motility, virulence, outer membrane biogenesis and other processes. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381116 [Multi-domain]  Cd Length: 99  Bit Score: 56.65  E-value: 1.64e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489205952  12 LIIDDEPQVTSELRELLENSGYRCVTSTHRESAIASFQADPnIGLVICDLYLGQDNGIRLIESLKEVAGNGRFfesIILT 91
Cdd:cd17574    1 LVVEDDEEIAELLSDYLEKEGYEVDTAADGEEALELAREEQ-PDLIILDVMLPGMDGFEVCRRLREKGSDIPI---IMLT 76
                         90       100
                 ....*....|....*....|...
gi 489205952  92 GHDGRQEVIEAMRVGAADYYQKP 114
Cdd:cd17574   77 AKDEEEDKVLGLELGADDYITKP 99
REC_OmpR_PmrA-like cd17624
phosphoacceptor receiver (REC) domain of PmrA-like OmpR family response regulators; This ...
11-121 5.56e-10

phosphoacceptor receiver (REC) domain of PmrA-like OmpR family response regulators; This subfamily contains various OmpR family response regulators including PmrA, BasR, QseB, tctD, and RssB, which are components of two-component regulatory systems (TCSs). The PmrA/PmrB TCS controls transcription of genes that are involved in lipopolysaccharide modification in the outer membrane of bacteria, increasing bacterial resistance to host-derived antimicrobial peptides. The BasS/BasR TCS functions as an iron- and zinc-sensing transcription regulator. The QseB/QseC TCS activates the flagella regulon by activating transcription of FlhDC. The RssA/RssB TCS regulates swarming behavior in Serratia marcescens. OmpR family DNA-binding response regulators contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381139 [Multi-domain]  Cd Length: 115  Bit Score: 55.57  E-value: 5.56e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489205952  11 VLIIDDEPQVTSELRELLENSGY--RCVTSTHR-ESAIASFQADpnigLVICDLYLGQDNGIRLIESLKevaGNGRFFES 87
Cdd:cd17624    1 ILLVEDDALLGDGLKTGLRKAGYavDWVRTGAEaEAALASGPYD----LVILDLGLPDGDGLDLLRRWR---RQGQSLPV 73
                         90       100       110
                 ....*....|....*....|....*....|....
gi 489205952  88 IILTGHDGRQEVIEAMRVGAADYYQKPVAPQELL 121
Cdd:cd17624   74 LILTARDGVDDRVAGLDAGADDYLVKPFALEELL 107
REC_citrate_TCS cd19925
phosphoacceptor receiver (REC) domain of citrate family two-component system response ...
11-126 8.01e-10

phosphoacceptor receiver (REC) domain of citrate family two-component system response regulators; This family includes Lactobacillus paracasei MaeR, Escherichia coli DcuR and DpiA, Klebsiella pneumoniae CitB, as well as Bacillus DctR, MalR, and CitT. These are all response regulators of two-component systems (TCSs) from the citrate family, and are involved in the transcriptional regulation of genes associated with L-malate catabolism (MaeRK), citrate-specific fermentation (DpiAB, CitAB), plasmid inheritance (DpiAB), anaerobic fumarate respiratory system (DcuRS), and malate transport/utilization (MalKR). REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381152 [Multi-domain]  Cd Length: 118  Bit Score: 55.33  E-value: 8.01e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489205952  11 VLIIDDEPQVTSELRELLEN-SGYRCVTSTHR-ESAIASFQaDPNIGLVICDLYLGQDNGIRLIESLKEvagngRFFES- 87
Cdd:cd19925    3 VLIVEDDPMVAEIHRAYVEQvPGFTVIGTAGTgEEALKLLK-ERQPDLILLDIYLPDGNGLDLLRELRA-----AGHDVd 76
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 489205952  88 IILTGHDGRQEVI-EAMRVGAADYYQKPVAPQELLHGLER 126
Cdd:cd19925   77 VIVVTAANDVETVrEALRLGVVDYLIKPFTFERLRQRLER 116
PRK10403 PRK10403
nitrate/nitrite response regulator protein NarP;
4-254 1.22e-09

nitrate/nitrite response regulator protein NarP;


Pssm-ID: 182431 [Multi-domain]  Cd Length: 215  Bit Score: 56.78  E-value: 1.22e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489205952   4 PASRHFSVLIIDDEPQVTSELRELLE-NSGYRCVT-STHRESAIASFQADpNIGLVICDLYLGQDNGIRLIESLKEVAGN 81
Cdd:PRK10403   2 PEATPFQVLIVDDHPLMRRGVRQLLElDPGFEVVAeAGDGASAIDLANRL-DPDVILLDLNMKGMSGLDTLNALRRDGVT 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489205952  82 GRFfesIILTGHDGRQEVIEAMRVGAADYYQKPVAPQELLhglerlesrlhERVRSQLSLSHV--NQRLEYLAEslnsiy 159
Cdd:PRK10403  81 AQI---IILTVSDASSDVFALIDAGADGYLLKDSDPEVLL-----------EAIRAGAKGSKVfsERVNQYLRE------ 140
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489205952 160 rdihkikyevhgnsqpsalRSEDSQPSAPpapvaesqvspsnplFGKLSPRQQAVARLVSKGLTNYQIAYELGITENTVK 239
Cdd:PRK10403 141 -------------------REMFGAEEDP---------------FSVLTERELDVLHELAQGLSNKQIASVLNISEQTVK 186
                        250
                 ....*....|....*
gi 489205952 240 LYVSQVLRLMHMHNR 254
Cdd:PRK10403 187 VHIRNLLRKLNVRSR 201
REC_CheY4-like cd17562
phosphoacceptor receiver (REC) domain of chemotaxis response regulator CheY4 and similar CheY ...
10-121 1.25e-09

phosphoacceptor receiver (REC) domain of chemotaxis response regulator CheY4 and similar CheY family proteins; CheY family chemotaxis response regulators (RRs) comprise about 17% of bacterial RRs and almost half of all RRs in archaea. This subfamily contains Vibrio cholerae CheY4 and similar CheY family RRs. CheY proteins control bacterial motility and participate in signaling phosphorelays and in protein-protein interactions. CheY RRs contain only the REC domain with no output/effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381110 [Multi-domain]  Cd Length: 118  Bit Score: 54.61  E-value: 1.25e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489205952  10 SVLIIDDEPQVTSELRELLENSGYRCVTSTHRESAIASFQADpNIGLVICDLYLGQDNGIRLIESLKEVAGNgRFFESII 89
Cdd:cd17562    2 KILAVDDSASIRQMVSFTLRGAGYEVVEAADGRDALSKAQSK-KFDLIITDQNMPNMDGIELIKELRKLPAY-KFTPILM 79
                         90       100       110
                 ....*....|....*....|....*....|..
gi 489205952  90 LTGHDGRQEVIEAMRVGAADYYQKPVAPQELL 121
Cdd:cd17562   80 LTTESSDEKKQEGKAAGATGWLVKPFDPEQLL 111
REC_OmpR_BsPhoP-like cd19937
phosphoacceptor receiver (REC) domain of BsPhoP-like OmpR family response regulators; Bacillus ...
12-121 1.46e-09

phosphoacceptor receiver (REC) domain of BsPhoP-like OmpR family response regulators; Bacillus subtilis PhoP (BsPhoP) is part of the PhoPR two-component system that participates in a signal transduction network that controls adaptation of the bacteria to phosphate deficiency by regulating (activating or repressing) genes of the Pho regulon upon phosphorylation by PhoR. When activated, PhoPR directs expression of phosphate scavenging enzymes, lowers synthesis of the phosphate-rich wall teichoic acid (WTA) and initiates synthesis of teichuronic acid, a non-phosphate containing replacement anionic polymer. Members of this subfamily belong to the OmpR family of DNA-binding response regulators, which are characterized by a REC domain and a winged helix-turn-helix (wHTH) DNA-binding output effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381164 [Multi-domain]  Cd Length: 116  Bit Score: 54.59  E-value: 1.46e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489205952  12 LIIDDEPQVTSELRELLENSGYRCVTSTHRESAIASFQADPnIGLVICDLYLGQDNGI---RLIESLKEVAGngrfFESI 88
Cdd:cd19937    1 LVVDDEEDIVELLKYNLEKEGYEVVTAYDGEEALKRAKDEK-PDLIILDLMLPGIDGLevcRILRSDPKTSS----IPII 75
                         90       100       110
                 ....*....|....*....|....*....|...
gi 489205952  89 ILTGHDGRQEVIEAMRVGAADYYQKPVAPQELL 121
Cdd:cd19937   76 MLTAKGEEFDKVLGLELGADDYITKPFSPRELL 108
CsgD COG2771
DNA-binding transcriptional regulator, CsgD family [Transcription];
206-261 2.81e-09

DNA-binding transcriptional regulator, CsgD family [Transcription];


Pssm-ID: 442052 [Multi-domain]  Cd Length: 188  Bit Score: 55.53  E-value: 2.81e-09
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 489205952 206 KLSPRQQAVARLVSKGLTNYQIAYELGITENTVKLYVSQVLRLMHMHNRTQLALAL 261
Cdd:COG2771  127 GLTPREREVLRLLAEGLTLKEIARILGISERTVRTHLKRIYRKLGVSSRAELVALA 182
REC_typeB_ARR-like cd17584
phosphoacceptor receiver (REC) domain of type B Arabidopsis response regulators (ARRs) and ...
11-120 4.72e-09

phosphoacceptor receiver (REC) domain of type B Arabidopsis response regulators (ARRs) and similar domains; Type-B ARRs (Arabidopsis response regulators) are a class of MYB-type transcription factors that act as major players in the transcriptional activation of cytokinin-responsive genes. They directly regulate the expression of type-A ARR genes and other downstream target genes. Cytokinin is a plant hormone implicated in many growth and development processes including shoot organogenesis, leaf senescence, sink/source relationships, vascular development, lateral bud release, and photomorphogenic development. Cytokinin signaling involves a phosphorelay cascade by histidine kinase receptors (AHKs), histidine phosphotransfer proteins (AHPs) and downstream ARRs. ARRs are divided into two groups, type-A and -B, according to their sequence and domain structure. Type-B ARRs contain a receiver (REC) domain and a large C-terminal extension that has characteristics of an effector or output domain, with a Myb-like DNA binding domain referred to as the GARP domain. The GARP domain is a motif specific to plant transcription factors. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381121 [Multi-domain]  Cd Length: 115  Bit Score: 53.02  E-value: 4.72e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489205952  11 VLIIDDEPQVTSELRELLENSGYRCVTSTHRESAIASFQADPN-IGLVICDLYLGQDNGIRLIESLKEVAGngrfFESII 89
Cdd:cd17584    1 VLVVDDDPTCLAILKRMLLRCGYQVTTCTDAEEALSMLRENKDeFDLVITDVHMPDMDGFEFLELIRLEMD----LPVIM 76
                         90       100       110
                 ....*....|....*....|....*....|.
gi 489205952  90 LTGHDGRQEVIEAMRVGAADYYQKPVAPQEL 120
Cdd:cd17584   77 MSADGSTSTVMKGLAHGACDYLLKPVSIEDL 107
REC_RpfG-like cd17551
phosphoacceptor receiver (REC) domain of cyclic di-GMP phosphodiesterase response regulator ...
11-121 5.68e-09

phosphoacceptor receiver (REC) domain of cyclic di-GMP phosphodiesterase response regulator RpfG and similar proteins; Cyclic di-GMP phosphodiesterase response regulator RpfG, together with sensory/regulatory protein RpfC, constitute a two-component system implicated in sensing and responding to the diffusible signal factor (DSF) that is essential for cell-cell signaling. RpfC is a hybrid sensor/histidine kinase that phosphorylates and activates RpfG, which degrades cyclic di-GMP to GMP, leading to the activation of Clp, a global transcriptional regulator that regulates a large set of genes in the DSF pathway. RpfG contains a CheY-like receiver domain attached to a histidine-aspartic acid-glycine-tyrosine-proline (HD-GYP) cyclic di-GMP phosphodiesterase domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381103 [Multi-domain]  Cd Length: 118  Bit Score: 52.83  E-value: 5.68e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489205952  11 VLIIDDEPQVTSELRELLENSGYRCVTSTH--REsAIASFQADPnIGLVICDLYLGQDNGIRLIESLKEVAGNgRFFESI 88
Cdd:cd17551    3 ILIVDDNPTNLLLLEALLRSAGYLEVVSFTdpRE-ALAWCRENP-PDLILLDYMMPGMDGLEFIRRLRALPGL-EDVPIV 79
                         90       100       110
                 ....*....|....*....|....*....|...
gi 489205952  89 ILTGHDGRQEVIEAMRVGAADYYQKPVAPQELL 121
Cdd:cd17551   80 MITADTDREVRLRALEAGATDFLTKPFDPVELL 112
PRK10955 PRK10955
envelope stress response regulator transcription factor CpxR;
11-147 7.55e-09

envelope stress response regulator transcription factor CpxR;


Pssm-ID: 182864 [Multi-domain]  Cd Length: 232  Bit Score: 54.81  E-value: 7.55e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489205952  11 VLIIDDEPQVTSELRELLENSGYRCVTSTHRESAIAsfQADPNIGLVICDLYLGQDNGirlIESLKEVAGNGRfFESIIL 90
Cdd:PRK10955   4 ILLVDDDRELTSLLKELLEMEGFNVIVAHDGEQALD--LLDDSIDLLLLDVMMPKKNG---IDTLKELRQTHQ-TPVIML 77
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 489205952  91 TGHDGRQEVIEAMRVGAADYYQKPVAPQELLhglerlesrlhERVRSQLSLSHVNQR 147
Cdd:PRK10955  78 TARGSELDRVLGLELGADDYLPKPFNDRELV-----------ARIRAILRRSHWSEQ 123
REC_OmpR_ChvI-like cd19936
phosphoacceptor receiver (REC) domain of ChvI-like OmpR family response regulators; ...
11-114 9.16e-09

phosphoacceptor receiver (REC) domain of ChvI-like OmpR family response regulators; Sinorhizobium meliloti ChvI is part of the ExoS/ChvI two-component regulatory system (TCS) that is required for nitrogen-fixing symbiosis and exopolysaccharide synthesis. ExoS/ChvI also play important roles in regulating biofilm formation, motility, nutrient utilization, and the viability of free-living bacteria. ChvI belongs to the OmpR family of DNA-binding response regulators that contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381163 [Multi-domain]  Cd Length: 99  Bit Score: 52.06  E-value: 9.16e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489205952  11 VLIIDDEPQVTSELRELLENSGYRCVTSTHRESAIASFQADPnIGLVICDLYLGQDNGIRLIESLKEVAGngrfFESIIL 90
Cdd:cd19936    1 IALVDDDRNILTSVSMALEAEGFSVETYTDGASALDGLNARP-PDLAILDIKMPRMDGMELLQRLRQKST----LPVIFL 75
                         90       100
                 ....*....|....*....|....
gi 489205952  91 TGHDGRQEVIEAMRVGAADYYQKP 114
Cdd:cd19936   76 TSKDDEIDEVFGLRMGADDYITKP 99
PRK11173 PRK11173
two-component response regulator; Provisional
11-120 1.60e-08

two-component response regulator; Provisional


Pssm-ID: 183013 [Multi-domain]  Cd Length: 237  Bit Score: 53.87  E-value: 1.60e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489205952  11 VLIIDDEpQVT-SELRELLENSGYRCVTSTHRESaIASFQADPNIGLVICDLYLGQDNGIRLIESLKEVAGNGRFFesii 89
Cdd:PRK11173   6 ILIVEDE-LVTrNTLKSIFEAEGYDVFEATDGAE-MHQILSENDINLVIMDINLPGKNGLLLARELREQANVALMF---- 79
                         90       100       110
                 ....*....|....*....|....*....|.
gi 489205952  90 LTGHDGRQEVIEAMRVGAADYYQKPVAPQEL 120
Cdd:PRK11173  80 LTGRDNEVDKILGLEIGADDYITKPFNPREL 110
PRK10529 PRK10529
DNA-binding transcriptional activator KdpE; Provisional
10-170 1.91e-08

DNA-binding transcriptional activator KdpE; Provisional


Pssm-ID: 182522 [Multi-domain]  Cd Length: 225  Bit Score: 53.65  E-value: 1.91e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489205952  10 SVLIIDDEPQVTSELRELLENSGYRCVTS-THRESAIASFQADPNigLVICDLYLGQDNGIRLIESLKEVAGngrfFESI 88
Cdd:PRK10529   3 NVLIVEDEQAIRRFLRTALEGDGMRVFEAeTLQRGLLEAATRKPD--LIILDLGLPDGDGIEFIRDLRQWSA----IPVI 76
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489205952  89 ILTGHDGRQEVIEAMRVGAADYYQKPVAPQELLHGLeRLESRLHERVRSQLSLSHvnqrleYLAESLNSIYRDIHKIKYE 168
Cdd:PRK10529  77 VLSARSEESDKIAALDAGADDYLSKPFGIGELQARL-RVALRRHSATPAPDPLVK------FSDVTVDLAARVIHRGEEE 149

                 ..
gi 489205952 169 VH 170
Cdd:PRK10529 150 VH 151
REC_CheY_CheY3 cd19923
phosphoacceptor receiver (REC) domain of chemotaxis response regulator CheY3 and similar CheY ...
10-127 1.96e-08

phosphoacceptor receiver (REC) domain of chemotaxis response regulator CheY3 and similar CheY family proteins; CheY family chemotaxis response regulators (RRs) comprise about 17% of bacterial RRs and almost half of all RRs in archaea. This subfamily contains Vibrio cholerae CheY3, Escherichia coli CheY, and similar CheY family RRs. CheY proteins control bacterial motility and participate in signaling phosphorelays and in protein-protein interactions. CheY RRs contain only the REC domain with no output/effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381150 [Multi-domain]  Cd Length: 119  Bit Score: 51.57  E-value: 1.96e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489205952  10 SVLIIDDEPQVTSELRELLENSGYRCVT-STHRESAIASFQAdPNIGLVICDLYLGQDNGIRLiesLKEVAGNGRFFESI 88
Cdd:cd19923    2 KVLVVDDFSTMRRIIKNLLKELGFNNVEeAEDGVDALEKLKA-GGFDFVITDWNMPNMDGLEL---LKTIRADGALSHLP 77
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 489205952  89 IL--TGHDGRQEVIEAMRVGAADYYQKPVAPQELLHGLERL 127
Cdd:cd19923   78 VLmvTAEAKKENVIAAAQAGVNNYIVKPFTAATLKEKLEKI 118
REC_NarL cd19931
phosphoacceptor receiver (REC) domain of Nitrate/Nitrite response regulator L (NarL); Nitrate ...
11-126 4.20e-08

phosphoacceptor receiver (REC) domain of Nitrate/Nitrite response regulator L (NarL); Nitrate/nitrite response regulator protein NarL contains an N-terminal REC domain and a C-terminal LuxR family helix-turn-helix (HTH) DNA-binding output domain. Escherichia coli NarL activates the expression of the nitrate reductase (narGHJI) and formate dehydrogenase-N (fdnGHI) operons, and represses the transcription of the fumarate reductase (frdABCD) operon in response to a nitrate/nitrite induction signal. Phosphorylation of the NarL REC domain releases the C-terminal HTH output domain that subsequently binds specific DNA promoter sites to repress or activate gene expression. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381158 [Multi-domain]  Cd Length: 117  Bit Score: 50.42  E-value: 4.20e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489205952  11 VLIIDDEPQVTSELRELLE-NSGYRCV--TSTHRESAIASFQADPNIglVICDLYLGQDNGIRLIESLKEVAGNGRFfes 87
Cdd:cd19931    1 VLLIDDHPLLRKGIKQLIElDPDFTVVgeASSGEEGIELAERLDPDL--ILLDLNMKGMSGLDTLKALREEGVSARI--- 75
                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 489205952  88 IILTGHDGRQEVIEAMRVGAADYYQKPVAPQELLHGLER 126
Cdd:cd19931   76 VILTVSDAEDDVVTALRAGADGYLLKDMEPEDLLEALKQ 114
REC_PA4781-like cd19920
phosphoacceptor receiver (REC) domain of cyclic di-GMP phosphodiesterase PA4781 and similar ...
11-115 4.58e-08

phosphoacceptor receiver (REC) domain of cyclic di-GMP phosphodiesterase PA4781 and similar domains; Pseudomonas aeruginosa cyclic di-GMP phosphodiesterase PA4781 contains an N-terminal REC domain and a C-terminal catalytic HD-GYP domain, characteristics of RpfG family response regulators. PA4781 is involved in cyclic di-3',5'-GMP (c-di-GMP) hydrolysis/degradation in a two-step reaction via the linear intermediate pGpG to produce GMP. Its unphosphorylated REC domain prevents accessibility of c-di-GMP to the active site. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381147 [Multi-domain]  Cd Length: 103  Bit Score: 49.82  E-value: 4.58e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489205952  11 VLIIDDEPQVTSELRELLENSGYRCVTSTHRESAIASFQADPnIGLVICDLYLGQDNGIRLIESLKEVAgNGRFFESIIL 90
Cdd:cd19920    1 ILIVDDVPDNLRLLSELLRAAGYRVLVATDGQQALQRAQAEP-PDLILLDVMMPGMDGFEVCRRLKADP-ATRHIPVIFL 78
                         90       100
                 ....*....|....*....|....*
gi 489205952  91 TGHDGRQEVIEAMRVGAADYYQKPV 115
Cdd:cd19920   79 TALTDTEDKVKGFELGAVDYITKPF 103
REC_OmpR_PrrA-like cd17627
phosphoacceptor receiver (REC) domain of PrrA-like OmpR family response regulators; The ...
11-121 5.04e-08

phosphoacceptor receiver (REC) domain of PrrA-like OmpR family response regulators; The Mycobacterium tuberculosis PrrA is part of the PrrA/PrrB two-component system (TCS) that has been implicated in early intracellular multiplication and is essential for viability. Also included in this subfamily is Mycobacterium tuberculosis MprA, part of the MprAB TCS that regulates EspR, a key regulator of the ESX-1 secretion system, and is required for establishment and maintenance of persistent infection in a tissue- and stage-specific fashion. PrrA and MprA belong to the OmpR family of DNA-binding response regulators, which contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381142 [Multi-domain]  Cd Length: 116  Bit Score: 50.46  E-value: 5.04e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489205952  11 VLIIDDEPQVTSELRELLENSGYRCVTSTHRESAIASFQADPnIGLVICDLYLGQDNGirlIESLKEVAGNGRFFESIIL 90
Cdd:cd17627    1 ILVVDDDRAVRESLRRSLRFEGYEVETAVDGAEALRVISGNR-PDAVVLDVMMPRLDG---LEVCRRLRAAGNDLPILVL 76
                         90       100       110
                 ....*....|....*....|....*....|.
gi 489205952  91 TGHDGRQEVIEAMRVGAADYYQKPVAPQELL 121
Cdd:cd17627   77 TARDSVSDRVAGLDAGADDYLVKPFALEELL 107
REC_DC-like cd17534
phosphoacceptor receiver (REC) domain of modulated diguanylate cyclase and similar domains; ...
10-125 5.11e-08

phosphoacceptor receiver (REC) domain of modulated diguanylate cyclase and similar domains; This groups includes a modulated diguanylate cyclase containing a PAS sensor domain from Desulfovibrio desulfuricans G20. Members of this group contain N-terminal REC domains and various output domains including the GGDEF, histidine kinase, and helix-turn-helix (HTH) DNA binding domains. Also included in this family is Mycobacterium tuberculosis PdtaR, a transcriptional antiterminator that contains a REC domain and an ANTAR RNA-binding output domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381089 [Multi-domain]  Cd Length: 117  Bit Score: 50.10  E-value: 5.11e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489205952  10 SVLIIDDEPQVTSELRELLENSGYRCVTSTHR-ESAIASF-QADPNigLVICDLYL-GQDNGIRLIESLKEvagngRFFE 86
Cdd:cd17534    2 KILIVEDEAIIALDLKEILESLGYEVVGIADSgEEAIELAeENKPD--LILMDINLkGDMDGIEAAREIRE-----KFDI 74
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 489205952  87 SII-LTGHDgRQEVIE-AMRVGAADYYQKPVAPQELLHGLE 125
Cdd:cd17534   75 PVIfLTAYS-DEETLErAKETNPYGYLVKPFNERELKAAIE 114
REC_2_GGDEF cd17544
second phosphoacceptor receiver (REC) domain of uncharacterized GGDEF domain proteins; This ...
11-120 6.14e-08

second phosphoacceptor receiver (REC) domain of uncharacterized GGDEF domain proteins; This family is composed of uncharacterized PleD-like response regulators that contain two N-terminal REC domains and a C-terminal diguanylate cyclase output domain with the characteristic GGDEF motif at the active site. Unlike PleD which contains a REC-like adaptor domain, the second REC domain of these uncharacterized GGDEF domain proteins, described in this model, contains characteristic metal-binding and active site residues. PleD response regulators are global regulators of cell metabolism in some important human pathogens. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381098 [Multi-domain]  Cd Length: 122  Bit Score: 50.21  E-value: 6.14e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489205952  11 VLIIDDEPQVTSELRELLENSGYRCVTSTHRESAIASFQADPNIGLVICDLYLGQDNGIRLIESLKEVAGNGRFfeSII- 89
Cdd:cd17544    3 VLVVDDSATSRNHLRALLRRHNFQVLEAANGQEALEVLEQHPDIKLVITDYNMPEMDGFELVREIRKKYSRDQL--AIIg 80
                         90       100       110
                 ....*....|....*....|....*....|.
gi 489205952  90 LTGHDGRQEVIEAMRVGAADYYQKPVAPQEL 120
Cdd:cd17544   81 ISASGDNALSARFIKAGANDFLTKPFLPEEF 111
REC_OmpR_MtrA-like cd17626
phosphoacceptor receiver (REC) domain of MtrA-like OmpR family response regulators; MtrA is ...
11-131 6.96e-08

phosphoacceptor receiver (REC) domain of MtrA-like OmpR family response regulators; MtrA is part of MtrA/MtrB (or MtrAB), a highly conserved two-component system (TCS) implicated in the regulation of cell division in the actinobacteria. In unicellular Mycobacterium tuberculosis, MtrAB coordinates DNA replication with cell division and regulates the transcription of resuscitation-promoting factor B. In filamentous Streptomyces venezuelae, it links antibiotic production to sporulation. MtrA belongs to the OmpR family of DNA-binding response regulators that contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381141 [Multi-domain]  Cd Length: 115  Bit Score: 49.78  E-value: 6.96e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489205952  11 VLIIDDEPQVTSELRELLENSGYRCVTSTHRESAIASFQADpNIGLVICDLYLGQDNGIRLIESLKEVAGngrfFESIIL 90
Cdd:cd17626    3 ILVVDDDAALAEMIGIVLRGEGFDPAFCGDGTQALAAFREV-RPDLVLLDLMLPGIDGIEVCRQIRAESG----VPIVML 77
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 489205952  91 TGHDGRQEVIEAMRVGAADYYQKPVAPQELlhgLERLESRL 131
Cdd:cd17626   78 TAKSDTVDVVLGLESGADDYVAKPFKPKEL---VARIRARL 115
PRK10766 PRK10766
two-component system response regulator TorR;
9-121 1.05e-07

two-component system response regulator TorR;


Pssm-ID: 182711 [Multi-domain]  Cd Length: 221  Bit Score: 51.19  E-value: 1.05e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489205952   9 FSVLIIDDEPQVTSELRELLENSGYRCVTSTHRESAIASFQADpNIGLVICDLYLGQDNGIRLIESLKEVAGNGrffesI 88
Cdd:PRK10766   3 YHILVVEDEPVTRARLQGYFEQEGYTVSEAASGAGMREIMQNQ-HVDLILLDINLPGEDGLMLTRELRSRSTVG-----I 76
                         90       100       110
                 ....*....|....*....|....*....|....
gi 489205952  89 IL-TGHDGRQEVIEAMRVGAADYYQKPVAPQELL 121
Cdd:PRK10766  77 ILvTGRTDSIDRIVGLEMGADDYVTKPLELRELL 110
PRK10430 PRK10430
two-component system response regulator DcuR;
11-114 1.23e-07

two-component system response regulator DcuR;


Pssm-ID: 182454 [Multi-domain]  Cd Length: 239  Bit Score: 51.26  E-value: 1.23e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489205952  11 VLIIDDEPQVtSEL--RELLENSGYRC--VTSTHRESAIASFQADPNIGLVICDLYLGQDNGIRLIESLKEVagnGRFFE 86
Cdd:PRK10430   4 VLIVDDDAMV-AELnrRYVAQIPGFQCcgTASTLEQAKEIIFNSDTPIDLILLDIYMQQENGLDLLPVLHEA---GCKSD 79
                         90       100
                 ....*....|....*....|....*...
gi 489205952  87 SIILTGHDGRQEVIEAMRVGAADYYQKP 114
Cdd:PRK10430  80 VIVISSAADAATIKDSLHYGVVDYLIKP 107
PRK10161 PRK10161
phosphate response regulator transcription factor PhoB;
11-131 1.59e-07

phosphate response regulator transcription factor PhoB;


Pssm-ID: 182277 [Multi-domain]  Cd Length: 229  Bit Score: 50.87  E-value: 1.59e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489205952  11 VLIIDDEPQVTSELRELLENSGYRCVTSTHRESAIASFQaDPNIGLVICDLYLGQDNGIRLIESLKEVAGNgRFFESIIL 90
Cdd:PRK10161   5 ILVVEDEAPIREMVCFVLEQNGFQPVEAEDYDSAVNQLN-EPWPDLILLDWMLPGGSGIQFIKHLKRESMT-RDIPVVML 82
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 489205952  91 TGHDGRQEVIEAMRVGAADYYQKPVAPQELLHGLERLESRL 131
Cdd:PRK10161  83 TARGEEEDRVRGLETGADDYITKPFSPKELVARIKAVMRRI 123
REC_TPR cd17589
phosphoacceptor receiver (REC) domain of uncharacterized tetratricopeptide repeat (TPR) ...
11-127 3.69e-07

phosphoacceptor receiver (REC) domain of uncharacterized tetratricopeptide repeat (TPR)-containing response regulators; Response regulators share the common phosphoacceptor REC domain and different output domains. This subfamily contains uncharacterized response regulators with TPR repeats as the effector or output domain, which might contain between 3 to 16 TPR repeats (each about 34 amino acids). TPR-containing proteins occur in all domains of life and the abundance of TPR-containing proteins in a bacterial proteome is not indicative of virulence. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays. Some members in this subfamily may contain inactive REC domains lacking canonical metal-binding and active site residues.


Pssm-ID: 381123 [Multi-domain]  Cd Length: 115  Bit Score: 47.64  E-value: 3.69e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489205952  11 VLIIDDEPQVTSELRELLENSGY-RCVTSTHRESAIASFQADpNIGLVICDLYLG-QDNGIRLIESLKE---VAGNGRFf 85
Cdd:cd17589    1 FLIVDDQPTFRSMLKSMLRSLGVtRIDTASSGEEALRMCENK-TYDIVLCDYNLGkGKNGQQLLEELRHkklISPSTVF- 78
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 489205952  86 esIILTGHDGRQEVIEAMRVGAADYYQKPVAPQELlhgLERL 127
Cdd:cd17589   79 --IMVTGESSRAMVLSALELEPDDYLLKPFTVSEL---RERL 115
PRK11361 PRK11361
acetoacetate metabolism transcriptional regulator AtoC;
3-120 4.24e-07

acetoacetate metabolism transcriptional regulator AtoC;


Pssm-ID: 183099 [Multi-domain]  Cd Length: 457  Bit Score: 50.62  E-value: 4.24e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489205952   3 KPASRhfsVLIIDDEPQVTSELRELLENSGYRCVTSTHRESAIASFqADPNIGLVICDLYLGQDNGIrliESLKEVAGNG 82
Cdd:PRK11361   2 TAINR---ILIVDDEDNVRRMLSTAFALQGFETHCANNGRTALHLF-ADIHPDVVLMDIRMPEMDGI---KALKEMRSHE 74
                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 489205952  83 RFFESIILTGHDGRQEVIEAMRVGAADYYQKPVAPQEL 120
Cdd:PRK11361  75 TRTPVILMTAYAEVETAVEALRCGAFDYVIKPFDLDEL 112
REC_OmpR_VirG cd17594
phosphoacceptor receiver (REC) domain of VirG-like OmpR family response regulators; VirG is ...
11-121 5.29e-07

phosphoacceptor receiver (REC) domain of VirG-like OmpR family response regulators; VirG is part of the VirA/VirG two-component system that regulates the expression of virulence (vir) genes. The histidine kinase VirA senses a phenolic wound response signal, undergoes autophosphorylation, and phosphorelays to the VirG response regulator, which induces transcription of the vir regulon. VirG belongs to the OmpR family of DNA-binding response regulators that contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381125 [Multi-domain]  Cd Length: 113  Bit Score: 47.44  E-value: 5.29e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489205952  11 VLIIDDEPQVTSELRELLENSGYRCVTSTHRESAIASFQADPnIGLVICDLYLGQDNGIRLIESLKEVAGngrfFESIIL 90
Cdd:cd17594    2 VLVVDDDAAMRHLLILYLRERGFDVTAAADGAEEARLMLHRR-VDLVLLDLRLGQESGLDLLRTIRARSD----VPIIII 76
                         90       100       110
                 ....*....|....*....|....*....|..
gi 489205952  91 TGHDGRQE-VIEAMRVGAADYYQKPVAPQELL 121
Cdd:cd17594   77 SGDRRDEIdRVVGLELGADDYLAKPFGLRELL 108
REC_OmpR_CpxR cd17623
phosphoacceptor receiver (REC) domain of CpxR-like OmpR family response regulators; CpxR is ...
11-121 5.57e-07

phosphoacceptor receiver (REC) domain of CpxR-like OmpR family response regulators; CpxR is part of the CpxA/CpxR two-component regulatory system that mediates envelope stress responses that is key for virulence and antibiotic resistance in several Gram negative pathogens. CpxR is a transcription factor/response regulator that controls the expression of numerous genes, including those of the classical porins OmpF and OmpC. It belongs to the OmpR family of DNA-binding response regulators that contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381138 [Multi-domain]  Cd Length: 115  Bit Score: 47.30  E-value: 5.57e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489205952  11 VLIIDDEPQVTSELRELLENSGYRCVTSTHRESAIASFqADPNIGLVICDLYLGQDNGirlIESLKEVAGNGRfFESIIL 90
Cdd:cd17623    1 ILLIDDDRELTELLTEYLEMEGFNVRAAHDGEQGLAAL-LEGSPDLVVLDVMLPKMNG---LDVLKELRKTSQ-VPVLML 75
                         90       100       110
                 ....*....|....*....|....*....|.
gi 489205952  91 TGHDGRQEVIEAMRVGAADYYQKPVAPQELL 121
Cdd:cd17623   76 TARGDDIDRILGLELGADDYLPKPFNPRELV 106
PRK10365 PRK10365
sigma-54-dependent response regulator transcription factor ZraR;
11-133 5.98e-07

sigma-54-dependent response regulator transcription factor ZraR;


Pssm-ID: 182412 [Multi-domain]  Cd Length: 441  Bit Score: 50.03  E-value: 5.98e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489205952  11 VLIIDDEPQVTSELRELLENSGYRCVTSTHRESAIASFQADPnIGLVICDLYLGQDNGIrliESLKEVAGNGRFFESIIL 90
Cdd:PRK10365   8 ILVVDDDISHCTILQALLRGWGYNVALANSGRQALEQVREQV-FDLVLCDVRMAEMDGI---ATLKEIKALNPAIPVLIM 83
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 489205952  91 TGHDGRQEVIEAMRVGAADYYQKPVAPQELLHGLERLESRLHE 133
Cdd:PRK10365  84 TAYSSVETAVEALKTGALDYLIKPLDFDNLQATLEKALAHTHS 126
REC_D1_PleD-like cd17538
first (D1) phosphoacceptor receiver (REC) domain of response regulator PleD and similar ...
11-115 6.78e-07

first (D1) phosphoacceptor receiver (REC) domain of response regulator PleD and similar domains; PleD contains a REC domain (D1) with the phosphorylatable aspartate, a REC-like adaptor domain (D2), and the enzymatic diguanylate cyclase (DGC) domain, also called the GGDEF domain according to a conserved sequence motif, as its output domain. The GGDEF-containing PleD response regulators are global regulators of cell metabolism in some important human pathogens. This model describes D1 of PleD and similar domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381093 [Multi-domain]  Cd Length: 104  Bit Score: 46.72  E-value: 6.78e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489205952  11 VLIIDDEPQVTSELRELLENSGYRCVTSTHRESAIASFQADPnIGLVICDLYLGQDNGIRLIESLKEVAGNgRFFESIIL 90
Cdd:cd17538    2 ILVVDDEPANRELLEALLSAEGYEVLTADSGQEALALAEEEL-PDLILLDVMMPGMDGFEVCRRLKEDPET-RHIPVIMI 79
                         90       100
                 ....*....|....*....|....*
gi 489205952  91 TGHDGRQEVIEAMRVGAADYYQKPV 115
Cdd:cd17538   80 TALDDREDRIRGLEAGADDFLSKPI 104
REC_hyHK_blue-like cd18161
phosphoacceptor receiver (REC) domain of hybrid sensor histidine kinase/response regulators ...
11-78 7.42e-07

phosphoacceptor receiver (REC) domain of hybrid sensor histidine kinase/response regulators similar to Pseudomonas savastanoi blue-light-activated histidine kinase; Typically, two-component regulatory systems (TCSs) consist of a sensor (histidine kinase) that responds to specific input(s) by modifying the output of a cognate response regulator (RR). TCSs allow organisms to sense and respond to changes in environmental conditions. Hybrid sensor histidine kinase (HK)/response regulators contain all the elements of a classical TCS in a single polypeptide chain. Pseudomonas savastanoi blue-light-activated histidine kinase is a photosensitive HK and RR that is involved in increased bacterial virulence upon exposure to light. RRs share the common phosphoacceptor REC domain and different effector/output domains such as DNA, RNA, ligand-binding, protein-binding, or enzymatic domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381145 [Multi-domain]  Cd Length: 102  Bit Score: 46.57  E-value: 7.42e-07
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 489205952  11 VLIIDDEPQVTSELRELLENSGYRCVTSTHRESAIASFQADPNIGLVICDLYL-GQDNGIRLIESLKEV 78
Cdd:cd18161    1 VLVVEDDPDVRRLTAEVLEDLGYTVLEAASGDEALDLLESGPDIDLLVTDVIMpGGMNGSQLAEEARRR 69
REC_OmpR_MtPhoP-like cd17615
phosphoacceptor receiver (REC) domain of MtPhoP-like OmpR family response regulators; ...
11-126 8.72e-07

phosphoacceptor receiver (REC) domain of MtPhoP-like OmpR family response regulators; Mycobacterium tuberculosis PhoP (MtPhoP) is part of the PhoP/PhoR two-component system that is involved in phosphate control by stimulating expression of genes involved in scavenging, transport and mobilization of phosphate, and repressing the utilization of nitrogen sources. Also included in this subfamily is Mycobacterium tuberculosis transcriptional regulatory protein TcrX, part of the two-component regulatory system TcrY/TcrX that may be involved in virulence. Members of this subfamily belong to the OmpR family of DNA-binding response regulators, which are characterized by a REC domain and a winged helix-turn-helix (wHTH) DNA-binding output effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381131 [Multi-domain]  Cd Length: 118  Bit Score: 46.96  E-value: 8.72e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489205952  11 VLIIDDEPQVTSELRELLENSGYRCVTSTHRESAIASFQaDPNIGLVICDLYLGQDNGIRLIESLKEVAGNGrffESIIL 90
Cdd:cd17615    2 VLVVDDEPNITELLSMALRYEGWDVETAADGAEALAAAR-EFRPDAVVLDIMLPDMDGLEVLRRLRADGPDV---PVLFL 77
                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 489205952  91 TGHDGRQEVIEAMRVGAADYYQKPVAPQEL---LHGLER 126
Cdd:cd17615   78 TAKDSVEDRIAGLTAGGDDYVTKPFSLEEVvarLRALLR 116
orf27 CHL00148
Ycf27; Reviewed
6-175 1.10e-06

Ycf27; Reviewed


Pssm-ID: 214376 [Multi-domain]  Cd Length: 240  Bit Score: 48.56  E-value: 1.10e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489205952   6 SRHFSVLIIDDEPQVTSELRELLENSGYRCVTSTHRESAIASFQAD-PNigLVICDLYLGQDNGIRLIESLKEvagngrf 84
Cdd:CHL00148   4 NSKEKILVVDDEAYIRKILETRLSIIGYEVITASDGEEALKLFRKEqPD--LVILDVMMPKLDGYGVCQEIRK------- 74
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489205952  85 fES----IILTGHDGRQEVIEAMRVGAADYYQKPVAPQEllhglerlesrLHERVRSQlsLSHVNQRLEYLAESLNSIYR 160
Cdd:CHL00148  75 -ESdvpiIMLTALGDVSDRITGLELGADDYVVKPFSPKE-----------LEARIRSV--LRRTNKKSFSSKIPNSSIIR 140
                        170
                 ....*....|....*....
gi 489205952 161 ----DIHKIKYEVHGNSQP 175
Cdd:CHL00148 141 igflKIDLNKKQVYKNNER 159
MalT COG2909
ATP-, maltotriose- and DNA-dependent transcriptional regulator MalT [Transcription];
210-261 1.15e-06

ATP-, maltotriose- and DNA-dependent transcriptional regulator MalT [Transcription];


Pssm-ID: 442153 [Multi-domain]  Cd Length: 184  Bit Score: 47.78  E-value: 1.15e-06
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|..
gi 489205952 210 RQQAVARLVSKGLTNYQIAYELGITENTVKLYVSQVLRLMHMHNRTQLALAL 261
Cdd:COG2909  126 LAALRRRLLAEGLSNKEIAERLFISVNTVKTHLRNIYRKLGVRSRTEAVARA 177
REC_LytTR_AlgR-like cd17532
phosphoacceptor receiver (REC) domain of LytTR/AlgR family response regulators similar to AlgR; ...
11-131 1.24e-06

phosphoacceptor receiver (REC) domain of LytTR/AlgR family response regulators similar to AlgR; Members of the LytTR/AlgR family of response regulators contain a REC domain and a unique LytTR DNA-binding output domain that lacks the helix-turn-helix motif and consists mostly of beta-strands. Transcriptional regulators with the LytTR-type output domains are involved in biosynthesis of extracellular polysaccharides, fimbriation, expression of exoproteins, including toxins, and quorum sensing. Included in this AlgR-like group of LytTR/AlgR family response regulators are Streptococcus agalactiae sensory transduction protein LytR, Pseudomonas aeruginosa positive alginate biosynthesis regulatory protein AlgR, Bacillus subtilis sensory transduction protein LytT, and Escherichia coli transcriptional regulatory protein BtsR, which are members of two-component regulatory systems. LytR and LytT are components of regulatory systems that regulate genes involved in cell wall metabolism. AlgR positively regulates the algD gene, which codes for a GDP-mannose dehydrogenase, a key enzyme in the alginate biosynthesis pathway. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381087 [Multi-domain]  Cd Length: 118  Bit Score: 46.38  E-value: 1.24e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489205952  11 VLIIDDEPQVTSELRELLENSGYRCVTSTHrESAIASFQA--DPNIGLVICDLYLGQDNGIRLIESLkevagnGRFFES- 87
Cdd:cd17532    1 ALIVDDEPLAREELRYLLEEHPDIEIVGEA-ENGEEALEAieELKPDVVFLDIQMPGLDGLELAKKL------SKLAKPp 73
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 489205952  88 --IILTGHDgrQEVIEAMRVGAADYYQKPVAPQELLHGLERLESRL 131
Cdd:cd17532   74 liVFVTAYD--EYAVEAFELNAVDYLLKPFSEERLAEALAKLRKRL 117
PRK10336 PRK10336
two-component system response regulator QseB;
57-139 1.27e-06

two-component system response regulator QseB;


Pssm-ID: 182387 [Multi-domain]  Cd Length: 219  Bit Score: 47.97  E-value: 1.27e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489205952  57 VICDLYLGQDNGIRLIESLKEvagNGRFFESIILTGHDGRQEVIEAMRVGAADYYQKPVAPQELLHGLERLESRLHERVR 136
Cdd:PRK10336  48 VILDLTLPGMDGRDILREWRE---KGQREPVLILTARDALAERVEGLRLGADDYLCKPFALIEVAARLEALMRRTNGQAS 124

                 ...
gi 489205952 137 SQL 139
Cdd:PRK10336 125 NEL 127
REC_OmpR_DrrD-like cd17625
phosphoacceptor receiver (REC) domain of DrrD-like OmpR family response regulators; DrrD is a ...
12-121 2.17e-06

phosphoacceptor receiver (REC) domain of DrrD-like OmpR family response regulators; DrrD is a OmpR/PhoB homolog from Thermotoga maritima whose function is not yet known. This subfamily also includes Streptococcus agalactiae transcriptional regulatory protein DltR, part of the DltS/DltR two-component system (TCS), and Pseudomonas aeruginosa transcriptional activator protein PfeR, part of the PfeR/PfeS TCS, which activates expression of the ferric enterobactin receptor. The DltS/DltR TCS regulates the expression of the dlt operon, which comprises four genes (dltA, dltB, dltC, and dltD) that catalyze the incorporation of D-alanine residues into the lipoteichoic acids. Members of this subfamily belong to the OmpR/PhoB family, which comprises of two domains, an N-terminal receiver domain and a C-terminal DNA-binding winged helix-turn-helix effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381140 [Multi-domain]  Cd Length: 115  Bit Score: 45.67  E-value: 2.17e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489205952  12 LIIDDEPQVTSELRELLENSGYRCVTSTHRESAIasFQADPNI-GLVICDLYLGQDNGIRLIESLKEvagNGRFFESIIL 90
Cdd:cd17625    1 LVVEDEKDLSEAITKHLKKEGYTVDVCFDGEEGL--EYALSGIyDLIILDIMLPGMDGLEVLKSLRE---EGIETPVLLL 75
                         90       100       110
                 ....*....|....*....|....*....|.
gi 489205952  91 TGHDGRQEVIEAMRVGAADYYQKPVAPQELL 121
Cdd:cd17625   76 TALDAVEDRVKGLDLGADDYLPKPFSLAELL 106
REC_2_DhkD-like cd17580
second phosphoacceptor receiver (REC) domain of Dictyostelium discoideum hybrid signal ...
11-122 3.16e-06

second phosphoacceptor receiver (REC) domain of Dictyostelium discoideum hybrid signal transduction histidine kinase D and similar domains; Dictyostelium discoideum hybrid signal transduction histidine kinase D (DhkD) is a large protein that contains two histidine kinase (HK) and two REC domains on the intracellular side of a single pass transmembrane domain, and extracellular PAS and PAC domains that likely are involved in ligand binding. This model represents the second REC domain and similar domains. DhkD activates the cAMP phosphodiesterase RegA to ensure proper prestalk and prespore patterning, tip formation, and the vertical elongation of the mound into a finger, in Dictyostelium discoideum. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381118 [Multi-domain]  Cd Length: 112  Bit Score: 45.14  E-value: 3.16e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489205952  11 VLIIDDEPQVTSELRELLENSGYRCVTSTHRESAIASFQA-DPNIglVICDLYLGQDNGIRLIESLKEVAGNGRFFeSII 89
Cdd:cd17580    1 ILVVDDNEDAAEMLALLLELEGAEVTTAHSGEEALEAAQRfRPDV--ILSDIGMPGMDGYELARRLRELPWLANTP-AIA 77
                         90       100       110
                 ....*....|....*....|....*....|...
gi 489205952  90 LTGHDGRQEVIEAMRVGAADYYQKPVAPQELLH 122
Cdd:cd17580   78 LTGYGQPEDRERALEAGFDAHLVKPVDPDELIE 110
REC smart00448
cheY-homologous receiver domain; CheY regulates the clockwise rotation of E. coli flagellar ...
10-63 1.12e-05

cheY-homologous receiver domain; CheY regulates the clockwise rotation of E. coli flagellar motors. This domain contains a phosphoacceptor site that is phosphorylated by histidine kinase homologues.


Pssm-ID: 214668 [Multi-domain]  Cd Length: 55  Bit Score: 41.79  E-value: 1.12e-05
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 489205952    10 SVLIIDDEPQVTSELRELLENSGYRCVTSTHRESAIASFQADPnIGLVICDLYL 63
Cdd:smart00448   2 RILVVDDDPLLRELLKALLEKEGYEVDEATDGEEALELLKEEK-PDLILLDIMM 54
REC_PatA-like cd17602
phosphoacceptor receiver (REC) domain of PatA and similar domains; Nostoc sp. (or Anabaena sp.) ...
11-114 1.35e-05

phosphoacceptor receiver (REC) domain of PatA and similar domains; Nostoc sp. (or Anabaena sp.) PatA is necessary for proper patterning of heterocysts along filaments. PatA contains phosphoacceptor REC domain at its C-terminus and an N-terminal PATAN (PatA N-terminus) domain, which was proposed in a bioinformatics study to mediate protein-protein interactions. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays. Some members of this group may have an inactive REC domain, lacking canonical metal-binding and active site residues.


Pssm-ID: 381129 [Multi-domain]  Cd Length: 102  Bit Score: 43.13  E-value: 1.35e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489205952  11 VLIIDDEPQVTSELRELLENSGYRCVTSTHRESAIAS-FQADPNigLVICDLYLGQDNG------IRLIESLKEVAgngr 83
Cdd:cd17602    1 VACVDDRPSIQKMIEYFLEKQGFRVVVIDDPLRALTTlLNSKPD--LILIDIDMPDLDGyelcslLRKSSALKDTP---- 74
                         90       100       110
                 ....*....|....*....|....*....|.
gi 489205952  84 ffeSIILTGHDGRQEVIEAMRVGAADYYQKP 114
Cdd:cd17602   75 ---IIMLTGKDGLVDRIRAKMAGASGYLTKP 102
REC_OmpR_YycF-like cd17614
phosphoacceptor receiver (REC) domain of YrcF-like OmpR family response regulators; YycF ...
11-121 1.49e-05

phosphoacceptor receiver (REC) domain of YrcF-like OmpR family response regulators; YycF appears to play an important role in cell wall integrity in a wide range of gram-positive bacteria, and may also modulate cell membrane integrity. It functions as part of a phosphotransfer system that ultimately controls the levels of competence within the bacteria. YycF belongs to the OmpR family of response regulators, which are characterized by a REC domain and a winged helix-turn-helix effector domain involved in DNA binding. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381130 [Multi-domain]  Cd Length: 115  Bit Score: 43.18  E-value: 1.49e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489205952  11 VLIIDDEPQVTSELRELLENSGYRCVTSTHRESAIASFQA-DPNigLVICDLYLGQDNGIRLIESLKEVAGngrfFESII 89
Cdd:cd17614    1 ILVVDDEKPISDILKFNLTKEGYEVVTAYDGREALEKVEEeQPD--LILLDLMLPEKDGLEVCREVRKTSN----VPIIM 74
                         90       100       110
                 ....*....|....*....|....*....|..
gi 489205952  90 LTGHDGRQEVIEAMRVGAADYYQKPVAPQELL 121
Cdd:cd17614   75 LTAKDSEVDKVLGLELGADDYVTKPFSNRELL 106
REC_TrrA-like cd17554
phosphoacceptor receiver (REC) domain of Thermotoga maritima response regulator TrrA and ...
10-77 1.72e-05

phosphoacceptor receiver (REC) domain of Thermotoga maritima response regulator TrrA and similar domains; Thermotoga maritima contains a two-component signal transduction system (TCS) composed of the ThkA sensory histidine kinase (HK) and its cognate response regulator (RR) TrrA; the specific function of the system is unknown. TCSs couple environmental stimuli to adaptive responses. TrrA is a stand-alone RR containing only a REC domain with no output/effector domain. The REC domain itself functions as an effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381106 [Multi-domain]  Cd Length: 113  Bit Score: 42.98  E-value: 1.72e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 489205952  10 SVLIIDDEPQVTSELRELLENSGYRCVTSTHRESAIASFQADPnIGLVICDLYLGQDNGIRLIESLKE 77
Cdd:cd17554    2 KILVVDDEENIRELYKEELEDEGYEVVTAGNGEEALEKLESED-PDLVILDIKMPGMDGLETLRKIRE 68
REC_PdtaR-like cd19932
phosphoacceptor receiver (REC) domain of PdtaR and similar proteins; This subfamily includes ...
11-130 2.35e-05

phosphoacceptor receiver (REC) domain of PdtaR and similar proteins; This subfamily includes Mycobacterium tuberculosis PdtaR, also called Rv1626, and similar proteins containing a REC domain and an ANTAR (AmiR and NasR transcription antitermination regulators) RNA-binding output domain. PdtaR is a response regulator that acts at the level of transcriptional antitermination and is a member of the PdtaR/PdtaS two-component regulatory system. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381159 [Multi-domain]  Cd Length: 118  Bit Score: 42.79  E-value: 2.35e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489205952  11 VLIIDDEPQVTSELRELLENSGYRCV--TSTHRESAIASFQADPNigLVICDLYLGQDNGirlIESLKEVAGNgRFFESI 88
Cdd:cd19932    3 VLIAEDEALIRMDLREMLEEAGYEVVgeASDGEEAVELAKKHKPD--LVIMDVKMPRLDG---IEAAKIITSE-NIAPIV 76
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 489205952  89 ILTGHDGRQEVIEAMRVGAADYYQKPVAPQELLHGLERLESR 130
Cdd:cd19932   77 LLTAYSQQDLVERAKEAGAMAYLVKPFSESDLIPAIEMAIAR 118
psREC-like_D2_PleD cd17539
REC-like adaptor domain (D2) of response regulator PleD; PleD contains a REC domain (D1) with ...
11-148 2.86e-05

REC-like adaptor domain (D2) of response regulator PleD; PleD contains a REC domain (D1) with the phosphorylatable aspartate, a pseudo receiver (psREC)-like adaptor domain (D2), and the enzymatic diguanylate cyclase (DGC) domain, also called the GGDEF domain according to a conserved sequence motif, as its output domain. The GGDEF-containing PleD response regulators are global regulators of cell metabolism in some important human pathogens. This model describes the REC-like adaptor domain D2 of PleD, which is an inactive domain.


Pssm-ID: 381094 [Multi-domain]  Cd Length: 124  Bit Score: 42.69  E-value: 2.86e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489205952  11 VLIIDDEPQVTSELRELLeNSGYRCVTSTHRESAIasFQA-DPNIGLVICDLYLGQDNGIRLIESLKEVAGNgRFFESII 89
Cdd:cd17539    1 VLLVDDRPSSAERIAAML-SSEHEVVVEADPDEAL--FRAaEGPFDLVIVSLALEDFDGLRLCSQLRSLERT-RQLPILA 76
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 489205952  90 LTGHDGRQEVIEAMRVGAADYYQKPVAPQELLhglerlesrlhERVRSQLSLSHVNQRL 148
Cdd:cd17539   77 VADPGDRGRLIRALEIGVNDYLVRPIDPNELL-----------ARVRTQIRRKRYTDYL 124
REC_Ycf29 cd19927
phosphoacceptor receiver (REC) domain of probable transcriptional regulator Ycf29; Ycf29 is a ...
11-114 3.29e-05

phosphoacceptor receiver (REC) domain of probable transcriptional regulator Ycf29; Ycf29 is a probable response regulator of a two-component system (TCS), typically consisting a sensor and a response regulator, that functions in adaptation to changing environments. Processes regulated by TCSs in bacteria include sporulation, pathogenicity, virulence, chemotaxis, and membrane transport. Ycf29 contains an N-terminal REC domain and a LuxR-type helix-turn-helix DNA-binding output domain. REC domains function as phosphorylation-mediated switches within RRs, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381154 [Multi-domain]  Cd Length: 102  Bit Score: 41.98  E-value: 3.29e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489205952  11 VLIIDDEPQVTSELRELLENSGYRCVTSTHRESAIaSFQADPNIGLVICDLYLGQDNGIRLIESLKEvagNGRF--FESI 88
Cdd:cd19927    1 ILLVDDDPGIRLAVKDYLEDQGFTVIAASNGLEAL-DLLNQYIPDLIISDIIMPGVDGYSLLGKLRK---NADFdtIPVI 76
                         90       100
                 ....*....|....*....|....*.
gi 489205952  89 ILTGHDGRQEVIEAMRVGAADYYQKP 114
Cdd:cd19927   77 FLTAKGMTSDRIKGYNAGCDGYLSKP 102
REC_HupR cd17596
phosphoacceptor receiver (REC) domain of hydrogen uptake protein regulator (HupR); Members of ...
10-152 4.35e-05

phosphoacceptor receiver (REC) domain of hydrogen uptake protein regulator (HupR); Members of this subfamily are response regulator components of two-component systems that regulates hydrogenase activity, including HupR and HoxA. HupR is part of the HupT/HupR system that controls the synthesis of the membrane-bound [NiFe]hydrogenase, HupSL, of the photosynthetic bacterium Rhodobacter capsulatus. It belongs to the nitrogen regulatory protein C (NtrC) family of response regulators, which activate transcription by RNA polymerase (RNAP) in response to a change in the environment. HupR is an unusual member of this family as it activates transcription when unphosphorylated, and transcription is inhibited by phosphorylation. Proteins in this subfamily contain an N-terminal REC domain, a central sigma-54 interaction domain that lacks ATPase activity, and a C-terminal DNA-binding domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381127 [Multi-domain]  Cd Length: 133  Bit Score: 42.35  E-value: 4.35e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489205952  10 SVLIIDDEPQVTSELRELLENSgYRCVTSTHRESAIASFQADPnIGLVICDLYLGQDNGirlIESLKEVagNGRFFES-- 87
Cdd:cd17596    2 TILVVDDEVRSLEALRRTLEED-FDVLTAASAEEALAILEEEW-VQVILCDQRMPGTTG---VEFLKEV--RERWPEVvr 74
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 489205952  88 IILTGHDGRQEVIEAMR-VGAADYYQKPVAPQELLhglerlesrlhERVRSQLSLSHVNQRLEYLA 152
Cdd:cd17596   75 IIISGYTDSEDIIAGINeAGIYQYLTKPWHPDQLL-----------LTVRNAARLFELQRENERLS 129
REC_hyHK_CKI1_RcsC-like cd17546
phosphoacceptor receiver (REC) domain of hybrid sensor histidine kinases/response regulators ...
11-121 5.06e-05

phosphoacceptor receiver (REC) domain of hybrid sensor histidine kinases/response regulators similar to Arabidopsis thaliana CKI1 and Escherichia coli RcsC; This family is composed of hybrid sensor histidine kinases/response regulators that are sensor histidine kinases (HKs) fused with a REC domain, similar to the sensor histidine kinase CKI1 from Arabidopsis thaliana, which is involved in multi-step phosphorelay (MSP) signaling that mediates responses to a variety of important stimuli in plants. MSP involves a signal being transferred from HKs via histidine phosphotransfer proteins (AHP1-AHP5) to nuclear response regulators. The CKI1 REC domain specifically interacts with the downstream signaling protein AHP2, AHP3 and AHP5. The plant MSP system has evolved from the prokaryotic two-component system (TCS), which allows organisms to sense and respond to changes in environmental conditions. This family also includes bacterial hybrid sensor HKs such as Escherichia coli RcsC, which is a component of the Rcs signalling pathway that controls a variety of physiological functions like capsule synthesis, cell division, and motility. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381099 [Multi-domain]  Cd Length: 113  Bit Score: 41.69  E-value: 5.06e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489205952  11 VLIIDDEP---QVtseLRELLENSGYRCVTSTHRESAIASFQADPnIGLVICDLYL-GQDnGIRLIESLKEVAGNGRFFE 86
Cdd:cd17546    1 VLVVDDNPvnrKV---LKKLLEKLGYEVDVAENGQEALELLKEEP-FDLVLMDLQMpVMD-GLEATRRIRELEGGGRRTP 75
                         90       100       110
                 ....*....|....*....|....*....|....*
gi 489205952  87 SIILTGHDGRQEVIEAMRVGAADYYQKPVAPQELL 121
Cdd:cd17546   76 IIALTANALEEDREKCLEAGMDDYLSKPVKLDQLK 110
pleD PRK09581
response regulator PleD; Reviewed
10-139 5.24e-05

response regulator PleD; Reviewed


Pssm-ID: 236577 [Multi-domain]  Cd Length: 457  Bit Score: 44.12  E-value: 5.24e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489205952  10 SVLIIDDEPQVTSELRELLENSgYRCVTSTHRESAiASFQADPNIGLVICDLYLGQDNGIRLIESLKEVAgNGRFFESII 89
Cdd:PRK09581 157 RILLVDDDVSQAERIANILKEE-FRVVVVSDPSEA-LFNAAETNYDLVIVSANFENYDPLRLCSQLRSKE-RTRYVPILL 233
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 489205952  90 LTGHDGRQEVIEAMRVGAADYYQKPVAPQELLhglerlesrlhERVRSQL 139
Cdd:PRK09581 234 LVDEDDDPRLVKALELGVNDYLMRPIDKNELL-----------ARVRTQI 272
PRK15115 PRK15115
response regulator GlrR; Provisional
10-125 6.21e-05

response regulator GlrR; Provisional


Pssm-ID: 185070 [Multi-domain]  Cd Length: 444  Bit Score: 44.06  E-value: 6.21e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489205952  10 SVLIIDDEPQVTSELRELLENSGYRCVTSTHRESAIASFQADpNIGLVICDLYLGQDNGIRLIESLKEVAGNgrfFESII 89
Cdd:PRK15115   7 HLLLVDDDPGLLKLLGMRLTSEGYSVVTAESGQEALRVLNRE-KVDLVISDLRMDEMDGMQLFAEIQKVQPG---MPVII 82
                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 489205952  90 LTGHDGRQEVIEAMRVGAADYYQKPVAPQELLHGLE 125
Cdd:PRK15115  83 LTAHGSIPDAVAATQQGVFSFLTKPVDRDALYKAID 118
dpiA PRK10046
two-component response regulator DpiA; Provisional
55-132 6.70e-05

two-component response regulator DpiA; Provisional


Pssm-ID: 182208 [Multi-domain]  Cd Length: 225  Bit Score: 43.08  E-value: 6.70e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 489205952  55 GLVICDLYLGQDNGIRLIESLKEvagnGRFFESIILTGHDGRQE-VIEAMRVGAADYYQKPVAPQELLHGLERLESRLH 132
Cdd:PRK10046  52 GLILLDNYLPDGRGINLLHELVQ----AHYPGDVVFTTAASDMEtVSEAVRCGVFDYLIKPIAYERLGQTLTRFRQRKH 126
REC_OmpR_BfmR-like cd19939
phosphoacceptor receiver (REC) domain of BfmR-like OmpR family response regulators; ...
10-139 7.48e-05

phosphoacceptor receiver (REC) domain of BfmR-like OmpR family response regulators; Acinetobacter baumannii BfmR is part of the BfmR/S two-component system that functions as the master regulator of biofilm initiation. BfmR confers resistance to complement-mediated bactericidal activity, independent of capsular polysaccharide, and also increases resistance to the clinically important antimicrobials meropenem and colistin, making it a potential antimicrobial target. Its inhibition would have the dual benefit of significantly decreasing in vivo survival and increasing sensitivity to selected antimicrobials. Members of this subfamily belong to the OmpR family of DNA-binding response regulators, which are characterized by a REC domain and a winged helix-turn-helix (wHTH) DNA-binding output effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381166 [Multi-domain]  Cd Length: 116  Bit Score: 41.20  E-value: 7.48e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489205952  10 SVLIIDDEPQVTSELRELLENSGYRCVTSTHRESAIASFQADPNiGLVICDLYLGQDNGIRLIESLKEvagngRFFESII 89
Cdd:cd19939    1 RILIVEDELELARLTRDYLIKAGLEVSVFTDGQRAVRRIIDEQP-SLVVLDIMLPGMDGLTVCREVRE-----HSHVPIL 74
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 489205952  90 -LTGHDGRQEVIEAMRVGAADYYQKPVAPQELLhglerlesrlhERVRSQL 139
Cdd:cd19939   75 mLTARTEEMDRVLGLEMGADDYLCKPFSPRELL-----------ARVRALL 114
PRK10643 PRK10643
two-component system response regulator PmrA;
11-139 7.59e-05

two-component system response regulator PmrA;


Pssm-ID: 182612 [Multi-domain]  Cd Length: 222  Bit Score: 42.72  E-value: 7.59e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489205952  11 VLIIDDEPQVTSELRELLENSGYRCVTSTHRESAIASFQADpNIGLVICDLYLGQDNGIRLIESLKEvagNGRFFESIIL 90
Cdd:PRK10643   3 ILIVEDDTLLLQGLILALQTEGYACDCASTAREAEALLESG-HYSLVVLDLGLPDEDGLHLLRRWRQ---KKYTLPVLIL 78
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 489205952  91 TGHDGRQEVIEAMRVGAADYYQKPVAPQELLHGLERLESRLHERVRSQL 139
Cdd:PRK10643  79 TARDTLEDRVAGLDVGADDYLVKPFALEELHARIRALIRRHQGQGENEL 127
REC_OmpR_BaeR-like cd19938
phosphoacceptor receiver (REC) domain of BaeR-like OmpR family response regulators; BaeR is ...
11-121 9.43e-05

phosphoacceptor receiver (REC) domain of BaeR-like OmpR family response regulators; BaeR is part of the BaeSR two-component system that is involved in regulating genes that confer multidrug and metal resistance. In Salmonella, BaeSR induces AcrD and MdtABC drug efflux systems, increasing multidrug and metal resistance. In Escherichia coli, BaeR stimulates multidrug resistance via mdtABC (multidrug transporter ABC, formerly known as yegMNO) genes, which encode a resistance-nodulation-cell division (RND) drug efflux system. Members of this subfamily belong to the OmpR family of DNA-binding response regulators, which are characterized by a REC domain and a winged helix-turn-helix (wHTH) DNA-binding output effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381165 [Multi-domain]  Cd Length: 114  Bit Score: 40.82  E-value: 9.43e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489205952  11 VLIIDDEPQVTSELRELLENSGYRCVTSTHRESAIASFQADPNiGLVICDLYLGQDNGIRLIESLkevagngRFFESIIL 90
Cdd:cd19938    2 ILIVEDEPKLAQLLIDYLRAAGYAPTLLAHGDQVLPYVRHTPP-DLILLDLMLPGTDGLTLCREI-------RRFSDVPI 73
                         90       100       110
                 ....*....|....*....|....*....|....
gi 489205952  91 TGHDGRQEVIE---AMRVGAADYYQKPVAPQELL 121
Cdd:cd19938   74 IMVTARVEEIDrllGLELGADDYICKPYSPREVV 107
REC_DivK-like cd17548
phosphoacceptor receiver (REC) domain of DivK and similar proteins; Caulobacter crescentus ...
11-121 1.14e-04

phosphoacceptor receiver (REC) domain of DivK and similar proteins; Caulobacter crescentus DivK is an essential response regulator that is involved in the complex phosphorelay pathways controlling both cell division and motility. It localizes cell cycle regulators to specific poles of the cell during division. DivK contains a stand-alone REC domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381100 [Multi-domain]  Cd Length: 115  Bit Score: 40.60  E-value: 1.14e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489205952  11 VLIIDDEPQVTSELRELLENSGYRCVTSTHRESAIASF-QADPNigLVICDLYLGQDNGIRLIESLKEVAGNGRFFesII 89
Cdd:cd17548    2 ILIVEDNPLNMKLARDLLESAGYEVLEAADGEEALEIArKEKPD--LILMDIQLPGMDGLEATRLLKEDPATRDIP--VI 77
                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 489205952  90 -LTGH---DGRQEVIEAmrvGAADYYQKPVAPQELL 121
Cdd:cd17548   78 aLTAYamkGDREKILEA---GCDGYISKPIDTREFL 110
ompR PRK09468
osmolarity response regulator; Provisional
6-121 1.24e-04

osmolarity response regulator; Provisional


Pssm-ID: 181883 [Multi-domain]  Cd Length: 239  Bit Score: 42.27  E-value: 1.24e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489205952   6 SRHFSVLIIDDEPQVTSELRELLENSGYRcVTSTHRESAIASFQADPNIGLVICDLYLGQDNGIRLIESLKEvAGNGrfF 85
Cdd:PRK09468   3 QENYKILVVDDDMRLRALLERYLTEQGFQ-VRSAANAEQMDRLLTRESFHLMVLDLMLPGEDGLSICRRLRS-QNNP--T 78
                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 489205952  86 ESIILTGHDGRQEVIEAMRVGAADYYQKPVAPQELL 121
Cdd:PRK09468  79 PIIMLTAKGEEVDRIVGLEIGADDYLPKPFNPRELL 114
REC_OmpR_NsrR-like cd18159
phosphoacceptor receiver (REC) domain of Streptococcus agalactiae NsrR-like OmpR family ...
11-114 1.26e-04

phosphoacceptor receiver (REC) domain of Streptococcus agalactiae NsrR-like OmpR family response regulators; Streptococcus agalactiae NsrR is a lantibiotic resistance-associated response regulator and is part of the nisin resistance operon. It is a member of the NsrRK two-component system (TCS) that is involved in the regulation of lantibiotic resistance genes such as a membrane-associated lipoprotein of LanI, and the nsr gene cluster which encodes for the resistance protein NSR and the ABC transporter NsrFP, both conferring resistance against nisin. This subfamily also includes Staphylococcus epidermidis GraR, part of the GraR/GraS TCS involved in resistance against cationic antimicrobial peptides, and Bacillus subtilis BceR, part of the BceS/BceR TCS involved in the regulation of bacitracin resistance. Members of this subfamily belong to the OmpR family of DNA-binding response regulators, which contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381143 [Multi-domain]  Cd Length: 113  Bit Score: 40.73  E-value: 1.26e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489205952  11 VLIIDDEPQVTSELRELLENSGYRCVTSTHRESAIASFqADPNIGLVICDLYLGQDNGI---RLIESLKEVAgngrffeS 87
Cdd:cd18159    1 ILIVEDDETIASLLKKHLEKWGYEVVLIEDFEDVLEEF-LQFKPDLVLLDINLPYFDGFywcREIRQISNVP-------I 72
                         90       100
                 ....*....|....*....|....*..
gi 489205952  88 IILTGHDGRQEVIEAMRVGAADYYQKP 114
Cdd:cd18159   73 IFISSRDDNMDQVMAINMGGDDYITKP 99
REC_OmpR_CusR-like cd19935
phosphoacceptor receiver (REC) domain of CusR-like OmpR family response regulators; ...
11-114 1.52e-04

phosphoacceptor receiver (REC) domain of CusR-like OmpR family response regulators; Escherichia coli CusR is part of the CusS/CusR two-component system (TCS) that is involved in response to copper and silver. Other members of this subfamily include Escherichia coli PcoR, Pseudomonas syringae CopR, and Streptomyces coelicolor CutR, which are all transcriptional regulatory proteins and components of TCSs that regulate genes involved in copper resistance and/or metabolism. member of the subfamily is Escherichia coli HprR (hydrogen peroxide response regulator), previously called YdeW, which is part of the HprSR (or YedVW) TCS involved in stress response to hydrogen peroxide, as well as Cupriavidus metallidurans CzcR, which is part of the CzcS/CzcR TCS involved in the control of cobalt, zinc, and cadmium homeostasis. Members of this subfamily belong to the OmpR family of DNA-binding response regulators, which contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381162 [Multi-domain]  Cd Length: 100  Bit Score: 40.12  E-value: 1.52e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489205952  11 VLIIDDEPQVTSELRELLENSGYRCVTSTHRESAIasFQA-----DpnigLVICDLYLGQDNGIRLIESLKEvagNGRFF 85
Cdd:cd19935    1 ILVVEDEKKLAEYLKKGLTEEGYAVDVAYDGEDGL--HLAltneyD----LIILDVMLPGLDGLEVLRRLRA---AGKQT 71
                         90       100
                 ....*....|....*....|....*....
gi 489205952  86 ESIILTGHDGRQEVIEAMRVGAADYYQKP 114
Cdd:cd19935   72 PVLMLTARDSVEDRVKGLDLGADDYLVKP 100
glnG PRK10923
nitrogen regulation protein NR(I); Provisional
11-134 1.55e-04

nitrogen regulation protein NR(I); Provisional


Pssm-ID: 182842 [Multi-domain]  Cd Length: 469  Bit Score: 42.55  E-value: 1.55e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489205952  11 VLIIDDEPQVTSELRELLENSGYRCVTSTHRESAIASF-QADPNIglVICDLYLGQDNGIRLIESLKEvagNGRFFESII 89
Cdd:PRK10923   6 VWVVDDDSSIRWVLERALAGAGLTCTTFENGNEVLEALaSKTPDV--LLSDIRMPGMDGLALLKQIKQ---RHPMLPVII 80
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 489205952  90 LTGHDGRQEVIEAMRVGAADYYQKPVAPQELLHGLERLESRLHER 134
Cdd:PRK10923  81 MTAHSDLDAAVSAYQQGAFDYLPKPFDIDEAVALVERAISHYQEQ 125
REC_HP-RR-like cd17573
phosphoacceptor receiver (REC) domain of orphan response regulator HP-RR and similar proteins; ...
11-114 1.80e-04

phosphoacceptor receiver (REC) domain of orphan response regulator HP-RR and similar proteins; Helicobacter pylori response regulator hp1043 (HP-RR) is an orphan response regulator which is phosphorylation-independent and is essential for growth. HP-RR functions as a cell growth-associated regulator in the absence of post-translational modification. Members of this subfamily contain REC and DNA-binding output domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381115 [Multi-domain]  Cd Length: 110  Bit Score: 40.11  E-value: 1.80e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489205952  11 VLIIDDEPQVTSELRELLENSGYRC-VTSTHREsaiASFQAD-PNIGLVICDLYLGQDNGIRLIESLKEvagNGRFFESI 88
Cdd:cd17573    1 ILLIEDDSTLGKEISKGLNEKGYQAdVAESLKD---GEYYIDiRNYDLVLVSDKLPDGNGLSIVSRIKE---KHPSIVVI 74
                         90       100
                 ....*....|....*....|....*.
gi 489205952  89 ILTGHDGRQEVIEAMRVGAADYYQKP 114
Cdd:cd17573   75 VLSDNPKTEQEIEAFKEGADDYIAKP 100
REC_OmpR_kpRstA-like cd17622
phosphoacceptor receiver (REC) domain of kpRstA-like OmpR family response regulators; ...
11-121 2.56e-04

phosphoacceptor receiver (REC) domain of kpRstA-like OmpR family response regulators; Klebsiella pneumoniae RstA (kpRstA) is part of the RstA/RstB two-component regulatory system that may play a regulatory role in virulence. It belongs to the OmpR family of DNA-binding response regulators that contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381137 [Multi-domain]  Cd Length: 116  Bit Score: 39.67  E-value: 2.56e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489205952  11 VLIIDDEPQVTSELRELLENSGYRCVTSTHRESAIASF-QADPNIglVICDLYLGQDNGIRLIESLKevagngRFFES-- 87
Cdd:cd17622    3 ILLVEDDPKLARLIADFLESHGFNVVVEHRGDRALEVIaREKPDA--VLLDIMLPGIDGLTLCRDLR------PKYQGpi 74
                         90       100       110
                 ....*....|....*....|....*....|....
gi 489205952  88 IILTGHDGRQEVIEAMRVGAADYYQKPVAPQELL 121
Cdd:cd17622   75 LLLTALDSDIDHILGLELGADDYVVKPVEPAVLL 108
REC_NtrC1-like cd17572
phosphoacceptor receiver (REC) domain of nitrogen regulatory protein C 1 (NtrC1) from Aquifex ...
11-120 3.04e-04

phosphoacceptor receiver (REC) domain of nitrogen regulatory protein C 1 (NtrC1) from Aquifex aeolicus and similar NtrC family response regulators; NtrC family proteins are transcriptional regulators that have REC, AAA+ ATPase/sigma-54 interaction, and DNA-binding output domains. This subfamily of NtrC proteins include Aquifex aeolicus NtrC1 and Vibrio quorum-sensing signal integrator LuxO. The N-terminal REC domain of NtrC proteins regulate the activity of the protein and its phosphorylation controls the AAA+ domain oligomerization, while the central AAA+ domain participates in nucleotide binding, hydrolysis, oligomerization, and sigma54 interaction. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381114 [Multi-domain]  Cd Length: 121  Bit Score: 39.49  E-value: 3.04e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489205952  11 VLIIDDEPQVTSELRELLENSGYR-CVTSTHREsAIASFQADPnIGLVICDLYLGQDNGIRLIESLKEVAGNGrffESII 89
Cdd:cd17572    1 VLLVEDSPSLAALYQEYLSDEGYKvTHVETGKE-ALAFLSDQP-PDVVLLDLKLPDMSGMEILKWIQERSLPT---SVIV 75
                         90       100       110
                 ....*....|....*....|....*....|.
gi 489205952  90 LTGHDGRQEVIEAMRVGAADYYQKPVAPQEL 120
Cdd:cd17572   76 ITAHGSVDIAVEAMRLGAYDFLEKPFDADRL 106
PRK13557 PRK13557
histidine kinase; Provisional
1-71 5.57e-04

histidine kinase; Provisional


Pssm-ID: 237425 [Multi-domain]  Cd Length: 540  Bit Score: 41.19  E-value: 5.57e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 489205952   1 MDKPASRHfsVLIIDDEPQVTSELRELLENSGYRCVTSTHRESAIASFQADPNIGLVICDLYL-GQDNGIRL 71
Cdd:PRK13557 410 IDRGGTET--ILIVDDRPDVAELARMILEDFGYRTLVASNGREALEILDSHPEVDLLFTDLIMpGGMNGVML 479
REC_OmpR_RegX3-like cd17621
phosphoacceptor receiver (REC) domain of RegX3-like OmpR family response regulators; RegX3 is ...
11-114 5.76e-04

phosphoacceptor receiver (REC) domain of RegX3-like OmpR family response regulators; RegX3 is a member of the SenX3-RegX3 two-component system that is involved in phosphate-sensing signal transduction. Phosphorylated RegX3 functions as a transcriptional activator of phoA. It induces transcription in phosphate limiting environment and also controls expression of several critical metabolic enzymes in aerobic condition. RegX3 belongs to the OmpR family of DNA-binding response regulators that contain N-terminal receiver and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381136 [Multi-domain]  Cd Length: 99  Bit Score: 38.33  E-value: 5.76e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489205952  11 VLIIDDEPQVTSELRELLENSGYRCVTSTHRESAIASFQ---ADpnigLVICDLYLGQDNGIRLIESLKEVAGngrfFES 87
Cdd:cd17621    1 VLVVEDEESFSDPLAYLLRKEGFEVTVATDGPAALAEFDragAD----IVLLDLMLPGLSGTEVCRQLRARSN----VPV 72
                         90       100
                 ....*....|....*....|....*..
gi 489205952  88 IILTGHDGRQEVIEAMRVGAADYYQKP 114
Cdd:cd17621   73 IMVTAKDSEIDKVVGLELGADDYVTKP 99
REC_RocR cd17530
phosphoacceptor receiver (REC) domain of response regulator RocR; The response regulator RocR ...
10-129 6.41e-04

phosphoacceptor receiver (REC) domain of response regulator RocR; The response regulator RocR from some pathogens contains an N-terminal phosphoreceiver (REC) domain and a C-terminal EAL domain that possesses c-di-GMP specific phosphodiesterase activity. The RocR REC domain is phosphorylated and modulates its EAL domain enzymatic activity, regulating the local level of c-di-GMP. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381086 [Multi-domain]  Cd Length: 123  Bit Score: 38.96  E-value: 6.41e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489205952  10 SVLIIDDEPQVTSELRELLENSGYRCV--TSTHRESAIASFQADPNIglVICDLYLGQDNGIRLIESLKEVAGNGrffES 87
Cdd:cd17530    2 RVLVLDDDPFQCMMAATILEDLGPGNVdeADDGREALVILLCNAPDI--IICDLKMPDMDGIEFLRHLAESHSNA---AV 76
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 489205952  88 IILTGHDGRqeVIEAMRVGAADY-------YQKPVAPQELLHGLERLES 129
Cdd:cd17530   77 ILMSGLDGG--ILESAETLAGANglnllgtLSKPFSPEELTELLTKYTA 123
PRK11697 PRK11697
two-component system response regulator BtsR;
10-132 7.87e-04

two-component system response regulator BtsR;


Pssm-ID: 236956 [Multi-domain]  Cd Length: 238  Bit Score: 39.83  E-value: 7.87e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489205952  10 SVLIIDDEPQVTSELRELLENSGY-----RCVTSTHRESAIASFQADpnigLVICDLYLGQDNGIRLI-----ESLKEVa 79
Cdd:PRK11697   3 KVLIVDDEPLAREELRELLQEEGDieivgECSNAIEAIGAIHRLKPD----VVFLDIQMPRISGLELVgmldpEHMPYI- 77
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 489205952  80 gngrffesIILTGHDgrQEVIEAMRVGAADYYQKPVAPQELLHGLERLESRLH 132
Cdd:PRK11697  78 --------VFVTAFD--EYAIKAFEEHAFDYLLKPIDPARLAKTLARLRQERS 120
REC_Spo0F-like cd17553
phosphoacceptor receiver (REC) domain of Spo0F and similar domains; Spo0F, a stand-alone ...
11-120 9.12e-04

phosphoacceptor receiver (REC) domain of Spo0F and similar domains; Spo0F, a stand-alone response regulator containing only a REC domain with no output/effector domain, controls sporulation in Bacillus subtilis through the exchange of a phosphoryl group. Bacillus subtilis forms spores when conditions for growth become unfavorable. The initiation of sporulation is controlled by a phosphorelay (an expanded version of the two-component system) that consists of four main components: a histidine kinase (KinA), a secondary messenger (Spo0F), a phosphotransferase (Spo0B), and a transcription factor (Spo0A). REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381105 [Multi-domain]  Cd Length: 117  Bit Score: 38.30  E-value: 9.12e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489205952  11 VLIIDDEPQVTSELRELLENSGYRCVTSTHRESAIASFQADPNiGLVICDLYLGQDNGIRLIESLKEVAGNGRFfesIIL 90
Cdd:cd17553    3 ILIVDDQYGIRILLNEVFNKEGYQTFQAANGLQALDIVTKERP-DLVLLDMKIPGMDGIEILKRMKVIDENIRV---IIM 78
                         90       100       110
                 ....*....|....*....|....*....|
gi 489205952  91 TGHDGRQEVIEAMRVGAADYYQKPVAPQEL 120
Cdd:cd17553   79 TAYGELDMIQESKELGALTHFAKPFDIDEI 108
REC_NtrC cd19919
phosphoacceptor receiver (REC) domain of DNA-binding transcriptional regulator NtrC; ...
10-114 9.24e-04

phosphoacceptor receiver (REC) domain of DNA-binding transcriptional regulator NtrC; DNA-binding transcriptional regulator NtrC is also called nitrogen regulation protein NR(I) or nitrogen regulator I (NRI). It contains an N-terminal receiver (REC) domain, followed by a sigma-54 interaction domain, and a C-terminal helix-turn-helix DNA-binding domain. It is part of the two-component regulatory system NtrB/NtrC, which controls expression of the nitrogen-regulated (ntr) genes in response to nitrogen limitation. DNA-binding response regulator NtrC is phosphorylated by NtrB; phosphorylation of the N-terminal REC domain activates the central sigma-54 interaction domain and leads to the transcriptional activation from promoters that require sigma(54)-containing RNA polymerase. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381146 [Multi-domain]  Cd Length: 116  Bit Score: 38.02  E-value: 9.24e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489205952  10 SVLIIDDEPQVTSELRELLENSGYRCVTSTHRESAIASFQADPNiGLVICDLYLGQDNGIRLIESLKEVAGNgrfFESII 89
Cdd:cd19919    2 TVWIVDDDSSIRWVLERALAGAGLTVTSFENAQEALAALASSQP-DVLISDIRMPGMDGLALLAQIKQRHPD---LPVII 77
                         90       100
                 ....*....|....*....|....*
gi 489205952  90 LTGHDGRQEVIEAMRVGAADYYQKP 114
Cdd:cd19919   78 MTAHSDLDSAVSAYQGGAFEYLPKP 102
REC_CheB-like cd17541
phosphoacceptor receiver (REC) domain of chemotaxis response regulator protein-glutamate ...
88-136 9.85e-04

phosphoacceptor receiver (REC) domain of chemotaxis response regulator protein-glutamate methylesterase CheB and similar chemotaxis proteins; Methylesterase CheB is a chemotaxis response regulator with an N-terminal REC domain and a C-terminal methylesterase domain. Chemotaxis is a behavior known in motile bacteria that directs their movement in response to chemical gradients. CheB is a phosphorylation-activated response regulator involved in the reversible modification of bacterial chemotaxis receptors. It catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR. The CheB REC domain packs against the active site of the C-terminal domain and inhibits methylesterase activity by directly restricting access to the active site. Also included in this family is chemotaxis response regulator CheY, which contains a stand-alone REC domain, and an uncharacterized subfamily composed of proteins containing an N-terminal REC domain and a C-terminal CheY-P phosphatase (CheC) domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381096 [Multi-domain]  Cd Length: 125  Bit Score: 38.14  E-value: 9.85e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|.
gi 489205952  88 IILTGH--DGRQEVIEAMRVGAADYYQKPVAPQELlhGLERLESRLHERVR 136
Cdd:cd17541   77 VMVSSLteEGAEITLEALELGAVDFIAKPSGGISL--DLEEIAEELIEKIK 125
REC_hyHK cd17598
phosphoacceptor receiver (REC) domain of uncharacterized hybrid sensor histidine kinase ...
11-121 1.05e-03

phosphoacceptor receiver (REC) domain of uncharacterized hybrid sensor histidine kinase/response regulators; Typically, two-component regulatory systems (TCSs) consist of a sensor (histidine kinase) that responds to specific input(s) by modifying the output of a cognate response regulator (RR). TCSs allow organisms to sense and respond to changes in environmental conditions. Hybrid sensor histidine kinase/response regulators contain all the elements of a classical TCS in a single polypeptide chain. RRs share the common phosphoacceptor REC domain and different effector/output domains such as DNA, RNA, ligand-binding, protein-binding, or enzymatic domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381128 [Multi-domain]  Cd Length: 118  Bit Score: 38.08  E-value: 1.05e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489205952  11 VLIIDDEPQVTSELRELLENSGYRC-VTSTHRESAIASFQADPNIglVICDLYLGQDNGIRLIESLKEVAGNgRFFESII 89
Cdd:cd17598    1 ILIVEDSPTQAEQLKHILEEQGYKVqVARNGREALAMLAEHRPTL--VISDIVMPEMDGYELCRKIKSDPDL-KDIPVIL 77
                         90       100       110
                 ....*....|....*....|....*....|..
gi 489205952  90 LTGHDGRQEVIEAMRVGAADYYQKPVAPQELL 121
Cdd:cd17598   78 LTTLSDPRDVIRGLECGADNFITKPYDEKYLL 109
REC_RcNtrC-like cd19928
phosphoacceptor receiver (REC) domain of Rhodobacter capsulatus nitrogen regulatory protein C ...
11-114 2.06e-03

phosphoacceptor receiver (REC) domain of Rhodobacter capsulatus nitrogen regulatory protein C (NtrC) and similar NtrC family response regulators; NtrC family proteins are transcriptional regulators that have REC, AAA+ ATPase/sigma-54 interaction, and DNA-binding output domains. This subfamily of NtrC proteins include NtrC, also called nitrogen regulator I (NRI), from Rhodobacter capsulatus, Azospirillum brasilense, and Azorhizobium caulinodans. NtrC is part of the NtrB/NtrC two-component system that controls the expression of the nitrogen-regulated (ntr) genes in response to nitrogen limitation. The N-terminal REC domain of NtrC proteins regulate the activity of the protein and its phosphorylation controls the AAA+ domain oligomerization, while the central AAA+ domain participates in nucleotide binding, hydrolysis, oligomerization, and sigma54 interaction. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381155 [Multi-domain]  Cd Length: 100  Bit Score: 36.71  E-value: 2.06e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489205952  11 VLIIDDEPQVTSELRELLENSGYRcVTSTHRESAIASFQADPNIGLVICDLYLGQDNGIRLIESLKEVAGNGRFfesIIL 90
Cdd:cd19928    1 ILVADDDRAIRTVLTQALGRAGYE-VRTTGNAATLWRWVEEGEGDLVITDVVMPDENGLDLIPRIKKARPDLPI---IVM 76
                         90       100
                 ....*....|....*....|....
gi 489205952  91 TGHDGRQEVIEAMRVGAADYYQKP 114
Cdd:cd19928   77 SAQNTLMTAVKAAERGAFEYLPKP 100
REC_CpdR_CckA-like cd18160
phosphoacceptor receiver (REC) domain of Brucella abortus CpdR and CckA, and similar domains; ...
11-114 2.16e-03

phosphoacceptor receiver (REC) domain of Brucella abortus CpdR and CckA, and similar domains; Two-component systems (TCSs), consisting of a sensor and a response regulator, are used by bacteria to adapt to changing environments. Processes regulated by TCSs in bacteria include sporulation, pathogenicity, virulence, chemotaxis and membrane transport. Response regulators share the common phosphoacceptor REC domain and differ output domains such as DNA, RNA, ligand, and protein-binding, or enzymatic domain. CpdR is a stand-alone REC protein. CckA is a sensor histidine kinase containing N-terminal PAS domains and a C-terminal REC domain. CpdR and CckA are components of a regulatory phosphorelay system (composed of CckA, ChpT, CtrA and CpdR) that controls Brucella abortus cell growth, division, and intracellular survival inside mammalian host cells. CckA autophosphorylates in the presence of ATP and transfers a phosphoryl group to the conserved aspartic acid residue on its C-terminal REC domain, which is relayed to the ChpT phosphotransferase. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381144 [Multi-domain]  Cd Length: 103  Bit Score: 36.71  E-value: 2.16e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489205952  11 VLIIDDEPQVTSELRELLENSGYRCVTSTHRESAIASFQADPNIGLVICDLYLGQDNGIRLIESLKEVAGNGRFfesIIL 90
Cdd:cd18160    2 ILLADDEPSVRKFIVTTLKKAGYAVTEAESGAEALEKLQQGKDIDIVVTDIVMPEMDGIELAREARKIDPDVKI---LFI 78
                         90       100
                 ....*....|....*....|....
gi 489205952  91 TGHDGRQEVIEAMRVGAADYYQKP 114
Cdd:cd18160   79 SGGAAAAPELLSDAVGDNATLKKP 102
REC_PilR cd19926
phosphoacceptor receiver (REC) domain of type 4 fimbriae expression regulatory protein PilR ...
11-114 3.09e-03

phosphoacceptor receiver (REC) domain of type 4 fimbriae expression regulatory protein PilR and similar proteins; Pseudomonas aeruginosa PilR is the response regulator of the PilS/PilR two-component regulatory system (PilSR TCS) that acts in conjunction with sigma-54 to regulate the expression of type 4 pilus (T4P) major subunit PilA. In addition, the PilSR TCS regulates flagellum-dependent swimming motility and pilus-dependent twitching motility. PilR contains an N-terminal REC domain, a central sigma-54 interaction domain, and a C-terminal Fis-type helix-turn-helix DNA-binding domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381153 [Multi-domain]  Cd Length: 100  Bit Score: 36.36  E-value: 3.09e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489205952  11 VLIIDDEPQVTSELRELLENSGYRCVTSTHRESAIASFQADPnIGLVICDLYLGQDNGIRLIESLkevagNGRFFES--I 88
Cdd:cd19926    1 VLVVDDEPDIRELLEITLGRMGLDVRSARNVKEARELLASEP-YDLCLTDMRLPDGSGLELVQHI-----QQRLPQTpvA 74
                         90       100
                 ....*....|....*....|....*.
gi 489205952  89 ILTGHDGRQEVIEAMRVGAADYYQKP 114
Cdd:cd19926   75 VITAYGSLDTAIEALKAGAFDFLTKP 100
REC_OmpR_CtrA cd17616
phosphoacceptor receiver (REC) domain of CtrA-like OmpR family response regulators; CtrA is ...
11-121 4.87e-03

phosphoacceptor receiver (REC) domain of CtrA-like OmpR family response regulators; CtrA is part of the CckA-ChpT-CtrA phosphorelay that is conserved in alphaproteobacteria and is important in orchestrating the cell cycle, polar development, and flagellar biogenesis. CtrA is the master regulator of flagella synthesis genes and also regulates genes involved in the cell cycle, exopolysaccharide synthesis, and cyclic-di-GMP signaling. CtrA is active as a transcription factor when phosphorylated. It is a member of the OmpR family of DNA-binding response regulators, characterized by a REC domain and a winged helix-turn-helix (wHTH) DNA-binding output effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381132 [Multi-domain]  Cd Length: 114  Bit Score: 36.23  E-value: 4.87e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489205952  11 VLIIDDEPQVTSELRELLENSGYRCVTSTHRESAIasfqadpNIG------LVICDLYLGQDNGIRLIESLKEVAGNGRF 84
Cdd:cd17616    1 VLLIEDDSATAQSIELMLKSEGFNVYTTDLGEEGL-------DLGklydydIILLDLNLPDMSGYEVLRTLRLAKVKTPI 73
                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 489205952  85 fesIILTGHDGRQEVIEAMRVGAADYYQKPVAPQELL 121
Cdd:cd17616   74 ---LILSGLADIEDKVKGLGFGADDYMTKPFHKDELV 107
Sig70_bacteroi1 TIGR02985
RNA polymerase sigma-70 factor, Bacteroides expansion family 1; This group of sigma factors ...
206-250 5.16e-03

RNA polymerase sigma-70 factor, Bacteroides expansion family 1; This group of sigma factors are members of the sigma-70 family (TIGR02937) and are found primarily in the genus Bacteroides. This family appears to have resulted from a lineage-specific expansion as B. thetaiotaomicron VPI-5482, Bacteroides forsythus ATCC 43037, Bacteroides fragilis YCH46 and Bacteroides fragilis NCTC 9343 contain 25, 12, 24 and 23 members, respectively. There are currentlyonly two known members of this family outside of the Bacteroides, in Rhodopseudomonas and Bradyrhizobium.


Pssm-ID: 274376 [Multi-domain]  Cd Length: 161  Bit Score: 36.77  E-value: 5.16e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 489205952  206 KLSPRQQAVARLV-SKGLTNYQIAYELGITENTVKLYVSQVLRLMH 250
Cdd:TIGR02985 113 KLPEQCREIFILSrFEGLSNKEIAEELGISVKTVEYHITKALKFLR 158
PRK10710 PRK10710
DNA-binding transcriptional regulator BaeR; Provisional
10-120 5.22e-03

DNA-binding transcriptional regulator BaeR; Provisional


Pssm-ID: 182665 [Multi-domain]  Cd Length: 240  Bit Score: 37.36  E-value: 5.22e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489205952  10 SVLIIDDEPQVTSELRELLENSGYRCVTSTHRESAIASFQADPNiGLVICDLYLGQDNGIRLIESLKevagngRFFE-SI 88
Cdd:PRK10710  12 RILIVEDEPKLGQLLIDYLQAASYATTLLSHGDEVLPYVRQTPP-DLILLDLMLPGTDGLTLCREIR------RFSDiPI 84
                         90       100       110
                 ....*....|....*....|....*....|....*
gi 489205952  89 ILTghDGRQEVIE---AMRVGAADYYQKPVAPQEL 120
Cdd:PRK10710  85 VMV--TAKIEEIDrllGLEIGADDYICKPYSPREV 117
REC_PhyR cd17540
phosphoacceptor receiver (REC) domain of response regulator PhyR and similar proteins; PhyR is ...
10-75 5.95e-03

phosphoacceptor receiver (REC) domain of response regulator PhyR and similar proteins; PhyR is a hybrid stress regulator that contains an N-terminal sigma-like (SL) domain and a C-terminal REC domain. Phosphorylation of the REC domain is known to promote binding of the SL domain to an anti-sigma factor. PhyR thus functions as an anti-anti-sigma factor in its phosphorylated state. It is involved in the general stress response. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381095 [Multi-domain]  Cd Length: 117  Bit Score: 35.69  E-value: 5.95e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489205952  10 SVLIIDDEPQVTSELRELLENSGYRcVTS---THRESAIASFQADPniGLVICDLYL-GQDNGIRLIESL 75
Cdd:cd17540    2 RVLIIEDEPLIAMDLEQIVEDLGHQ-VVGiarTRDEAVALARRERP--DLILADIQLaDGSSGIDAVNEI 68
Sigma70_r4_2 pfam08281
Sigma-70, region 4; Region 4 of sigma-70 like sigma-factors are involved in binding to the -35 ...
203-249 6.67e-03

Sigma-70, region 4; Region 4 of sigma-70 like sigma-factors are involved in binding to the -35 promoter element via a helix-turn-helix motif.


Pssm-ID: 400535 [Multi-domain]  Cd Length: 54  Bit Score: 33.97  E-value: 6.67e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 489205952  203 LFGKLSPRQQAVARLVS-KGLTNYQIAYELGITENTVKLYVSQVLRLM 249
Cdd:pfam08281   7 ALEELPPRQREVFLLRYlEGLSYAEIAELLGISEGTVKSRLSRARKKL 54
sigma70-ECF TIGR02937
RNA polymerase sigma factor, sigma-70 family; This model encompasses all varieties of the ...
206-249 8.60e-03

RNA polymerase sigma factor, sigma-70 family; This model encompasses all varieties of the sigma-70 type sigma factors including the ECF subfamily. A number of sigma factors have names with a different number than 70 (i.e. sigma-38), but in fact, all except for the Sigma-54 family (TIGR02395) are included within this family. Several Pfam models hit segments of these sequences including Sigma-70 region 2 (pfam04542) and Sigma-70, region 4 (pfam04545), but not always above their respective trusted cutoffs.


Pssm-ID: 274357 [Multi-domain]  Cd Length: 158  Bit Score: 36.17  E-value: 8.60e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 489205952  206 KLSPRQQAVARLV-SKGLTNYQIAYELGITENTVKLYVSQVLRLM 249
Cdd:TIGR02937 110 KLPEREREVLVLRyLEGLSYKEIAEILGISVGTVKRRLKRARKKL 154
REC_GlnL-like cd17565
phosphoacceptor receiver (REC) domain of transcriptional regulatory protein GlnL and similar ...
13-115 8.80e-03

phosphoacceptor receiver (REC) domain of transcriptional regulatory protein GlnL and similar proteins; Bacillus subtilis GlnL is part of the GlnK-GlnL (formerly YcbA-YcbB) two-component system that positively regulates the expression of the glsA-glnT (formerly ybgJ-ybgH) operon in response to glutamine. It contains a REC domain and a DNA-binding output domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381112 [Multi-domain]  Cd Length: 103  Bit Score: 34.94  E-value: 8.80e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489205952  13 IIDDEPQVTSELRELLENSGYRCVTSTHRESAIASFQ---ADPNIGLVicDLYLGQDNGIRLIESLKEVAGNGRFfesII 89
Cdd:cd17565    3 IVDDDKNIIKILSDIIEDDDLGEVVGEADNGAQAYDEilfLQPDIVLI--DLLMPGMDGIQLVRKLKDTGSNGKF---IM 77
                         90       100
                 ....*....|....*....|....*.
gi 489205952  90 LTGHDGRQEVIEAMRVGAADYYQKPV 115
Cdd:cd17565   78 ISQVSDKEMIGKAYQAGIEFFINKPI 103
REC_CheV-like cd19924
phosphoacceptor receiver (REC) domain of chemotaxis protein CheV and similar proteins; This ...
11-114 8.88e-03

phosphoacceptor receiver (REC) domain of chemotaxis protein CheV and similar proteins; This subfamily includes the REC domains of Bacillus subtilis chemotaxis protein CheV, Myxococcus xanthus gliding motility regulatory protein FrzE, and similar proteins. CheV is a hybrid protein with an N-terminal CheW-like domain and a C-terminal CheY-like REC domain. The CheV pathway is one of three systems employed by B. subtilis for sensory adaptation that contribute to chemotaxis. It is involved in the transmission of sensory signals from chemoreceptors to flagellar motors. Together with CheW, it is involved in the coupling of methyl-accepting chemoreceptors to the central two-component histidine kinase CheA. FrzE is a hybrid sensor histidine kinase/response regulator that is part of the Frz pathway that controls cell reversal frequency to support directional motility during swarming and fruiting body formation. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381151 [Multi-domain]  Cd Length: 111  Bit Score: 35.43  E-value: 8.88e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489205952  11 VLIIDDEPQVTSELRELLENSGYRCVTSTHRESA------IASFQADPN--IGLVICDLYLGQDNGIRLIESLKEvagNG 82
Cdd:cd19924    1 ILVVDDSPTARKQLRDLLKNLGFEIAEAVDGEEAlnklenLAKEGNDLSkeLDLIITDIEMPKMDGYELTFELRD---DP 77
                         90       100       110
                 ....*....|....*....|....*....|....
gi 489205952  83 RF--FESIILTGHDGRQEVIEAMRVGAADYYQKP 114
Cdd:cd19924   78 RLanIPVILNSSLSGEFSRARGKKVGADAYLAKF 111
PRK11517 PRK11517
DNA-binding response regulator HprR;
11-149 9.17e-03

DNA-binding response regulator HprR;


Pssm-ID: 183172 [Multi-domain]  Cd Length: 223  Bit Score: 36.80  E-value: 9.17e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489205952  11 VLIIDDEPQVTSELRELLENSGYRC-VTSTHRESAIASFQADpnIGLVICDLYLGQDNGIRLIESLKEVAGNgrffESII 89
Cdd:PRK11517   3 ILLIEDNQRTQEWVTQGLSEAGYVIdAVSDGRDGLYLALKDD--YALIILDIMLPGMDGWQILQTLRTAKQT----PVIC 76
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 489205952  90 LTGHDGRQEVIEAMRVGAADYYQKPVAPQELLhglerlesrlhERVRSQLSLSH-VNQRLE 149
Cdd:PRK11517  77 LTARDSVDDRVRGLDSGANDYLVKPFSFSELL-----------ARVRAQLRQHHaLNSTLE 126
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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