NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|489205911|ref|WP_003114945|]
View 

alpha/beta fold hydrolase [Pseudomonas aeruginosa]

Protein Classification

alpha/beta fold hydrolase( domain architecture ID 11426811)

alpha/beta hydrolase family protein catalyzes the hydrolysis of substrates with different chemical composition or physicochemical properties using a nucleophile-His-acid catalytic triad

PubMed:  1409539|12369917

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
MenH COG0596
2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, ...
 84-226 1.40e-03

2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, alpha/beta hydrolase fold [Coenzyme transport and metabolism, General function prediction only]; 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, alpha/beta hydrolase fold is part of the Pathway/BioSystem: Menaquinone biosynthesis


:

Pssm-ID: 440361 [Multi-domain]  Cd Length: 221  Bit Score: 39.98  E-value: 1.40e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489205911  84 VVFIHGWkhnagrdDGNVASFNKALANLASsgvlgKRRLVglYVGWRGksmHGLYSENLTYWDRKAVAEEVgrggvAELF 163
Cdd:COG0596   26 VVLLHGL-------PGSSYEWRPLIPALAA-----GYRVI--APDLRG---HGRSDKPAGGYTLDDLADDL-----AALL 83

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 489205911 164 AQLErIDRkdrnyLVIVGHSFGGAITLgalhdpllerLLALQDGQRIRafgdAVIMLNPAIEA 226
Cdd:COG0596   84 DALG-LER-----VVLVGHSMGGMVAL----------ELAARHPERVA----GLVLVDEVLAA 126
 
Name Accession Description Interval E-value
MenH COG0596
2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, ...
 84-226 1.40e-03

2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, alpha/beta hydrolase fold [Coenzyme transport and metabolism, General function prediction only]; 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, alpha/beta hydrolase fold is part of the Pathway/BioSystem: Menaquinone biosynthesis


Pssm-ID: 440361 [Multi-domain]  Cd Length: 221  Bit Score: 39.98  E-value: 1.40e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489205911  84 VVFIHGWkhnagrdDGNVASFNKALANLASsgvlgKRRLVglYVGWRGksmHGLYSENLTYWDRKAVAEEVgrggvAELF 163
Cdd:COG0596   26 VVLLHGL-------PGSSYEWRPLIPALAA-----GYRVI--APDLRG---HGRSDKPAGGYTLDDLADDL-----AALL 83

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 489205911 164 AQLErIDRkdrnyLVIVGHSFGGAITLgalhdpllerLLALQDGQRIRafgdAVIMLNPAIEA 226
Cdd:COG0596   84 DALG-LER-----VVLVGHSMGGMVAL----------ELAARHPERVA----GLVLVDEVLAA 126
 
Name Accession Description Interval E-value
MenH COG0596
2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, ...
 84-226 1.40e-03

2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, alpha/beta hydrolase fold [Coenzyme transport and metabolism, General function prediction only]; 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, alpha/beta hydrolase fold is part of the Pathway/BioSystem: Menaquinone biosynthesis


Pssm-ID: 440361 [Multi-domain]  Cd Length: 221  Bit Score: 39.98  E-value: 1.40e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489205911  84 VVFIHGWkhnagrdDGNVASFNKALANLASsgvlgKRRLVglYVGWRGksmHGLYSENLTYWDRKAVAEEVgrggvAELF 163
Cdd:COG0596   26 VVLLHGL-------PGSSYEWRPLIPALAA-----GYRVI--APDLRG---HGRSDKPAGGYTLDDLADDL-----AALL 83

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 489205911 164 AQLErIDRkdrnyLVIVGHSFGGAITLgalhdpllerLLALQDGQRIRafgdAVIMLNPAIEA 226
Cdd:COG0596   84 DALG-LER-----VVLVGHSMGGMVAL----------ELAARHPERVA----GLVLVDEVLAA 126
PldB COG2267
Lysophospholipase, alpha-beta hydrolase superfamily [Lipid transport and metabolism];
84-227 5.47e-03

Lysophospholipase, alpha-beta hydrolase superfamily [Lipid transport and metabolism];


Pssm-ID: 441868 [Multi-domain]  Cd Length: 221  Bit Score: 38.44  E-value: 5.47e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489205911  84 VVFIHGWKHNAGRddgnvasFNKALANLASSG--VLGkrrlvglyVGWRGksmHGLYSENLTYWDRKAVAeevgrggVAE 161
Cdd:COG2267   31 VVLVHGLGEHSGR-------YAELAEALAAAGyaVLA--------FDLRG---HGRSDGPRGHVDSFDDY-------VDD 85

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 489205911 162 LFAQLERIDRKDRNYLVIVGHSFGGAITLgalhdpllerLLALQDGQRIrafgDAVIMLNPAIEAN 227
Cdd:COG2267   86 LRAALDALRARPGLPVVLLGHSMGGLIAL----------LYAARYPDRV----AGLVLLAPAYRAD 137
DAP2 COG1506
Dipeptidyl aminopeptidase/acylaminoacyl peptidase [Amino acid transport and metabolism];
83-193 5.74e-03

Dipeptidyl aminopeptidase/acylaminoacyl peptidase [Amino acid transport and metabolism];


Pssm-ID: 441115 [Multi-domain]  Cd Length: 234  Bit Score: 38.46  E-value: 5.74e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489205911  83 MVVFIHGWKHNAGRddgnvaSFNKALANLASSGVlgkrrlVGLYVGWR--GKSMHGLYSENltYWDRKAVAEEV-GRGGV 159
Cdd:COG1506   25 VVVYVHGGPGSRDD------SFLPLAQALASRGY------AVLAPDYRgyGESAGDWGGDE--VDDVLAAIDYLaARPYV 90

                         90       100       110
                 ....*....|....*....|....*....|....
gi 489205911 160 aelfaqleridrkDRNYLVIVGHSFGGAITLGAL 193
Cdd:COG1506   91 -------------DPDRIGIYGHSYGGYMALLAA 111
YbbA COG2819
Predicted hydrolase of the alpha/beta superfamily [General function prediction only];
142-193 6.88e-03

Predicted hydrolase of the alpha/beta superfamily [General function prediction only];


Pssm-ID: 442067 [Multi-domain]  Cd Length: 250  Bit Score: 38.04  E-value: 6.88e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 489205911 142 LTYWDRKAVAEEVGRGGVAELFAQ-LE-----RIDRK---DRNYLVIVGHSFGGAITLGAL 193
Cdd:COG2819   88 YTPPPAPGYPGPGGPGGGADAFLRfLEeelkpYIDKRyrtDPERTGLIGHSLGGLFSLYAL 148
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH