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Conserved domains on  [gi|489200333|ref|WP_003109557|]
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MULTISPECIES: ATP-binding protein [Pseudomonas]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PRK10337 super family cl32501
sensor protein QseC; Provisional
 172-429 7.61e-43

sensor protein QseC; Provisional


The actual alignment was detected with superfamily member PRK10337:

Pssm-ID: 182388 [Multi-domain]  Cd Length: 449  Bit Score: 156.35  E-value: 7.61e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489200333 172 GQGLAPLKRIRDALTRRGADSLEPLELAALPSELKPLVETQNQLFQRIAQAIERERRLTGDAAHELRSPLTAIKTHLQVA 251
Cdd:PRK10337 183 GRELAPLKKLALALRMRDPDSETPLNATGVPSEVRPLVEALNQLFARTHAMMVRERRFTSDAAHELRSPLAALKVQTEVA 262

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489200333 252 RMT--EGAAAEQALAHAEEGADRLHRTLDQLLLLARVEGSLSFDDGVQCSAEDAARVAMHDA-GHGDERMFELRLADGLS 328
Cdd:PRK10337 263 QLSddDPQARKKALLQLHAGIDRATRLVDQLLTLSRLDSLDNLQDVAEIPLEDLLQSAVMDIyHTAQQAGIDVRLTLNAH 342

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489200333 329 EAPLEVPSVLAIAALRNLLDNALRHTAAGTRVELAVETEqgcaRFHVRDHGPGIAEADLPHLTRRFWR--HGKSGGSGLG 406
Cdd:PRK10337 343 PVIRTGQPLLLSLLVRNLLDNAIRYSPQGSVVDVTLNAR----NFTVRDNGPGVTPEALARIGERFYRppGQEATGSGLG 418

                        250       260
                 ....*....|....*....|...
gi 489200333 407 LAIVQAIVQRCQCRLDFDSRADG 429
Cdd:PRK10337 419 LSIVRRIAKLHGMNVSFGNAPEG 441
2CSK_N super family cl07224
Two-component sensor kinase N-terminal; This domain is found in bacterial two-component sensor ...
 16-146 6.51e-06

Two-component sensor kinase N-terminal; This domain is found in bacterial two-component sensor kinases towards the N-terminus. It recognizes Autoinducer 3 (AI-3), epinephrine, norepineprhine and Fe(III) (Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).


The actual alignment was detected with superfamily member pfam08521:

Pssm-ID: 430051  Cd Length: 142  Bit Score: 45.71  E-value: 6.51e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489200333   16 ILLWSLAAAWMLCDLRGQMMRSFDQRLAASARMVAGLLQQLPQPQPADgqTTRLSAEQLGIPNG--MACQVSSLRGEVLA 93
Cdd:pfam08521   2 LLLWLLSAAITYRVARNAANRAYDRALLASARALAEQVRVEDGELQVD--LPPAALEMLRADAEdrVYYQVLDPDGRLLA 79

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 489200333   94 QSHATPERALDSTASGFRDQEINGVLWRSFTV--------QAGDLRVSTADRLEERDVLQR 146
Cdd:pfam08521  80 GDADLPLPPGYAGEPRFYDAEYRGEPVRVAALarplagpgASGPVLVQVAETLEKRDALAR 140
 
Name Accession Description Interval E-value
PRK10337 PRK10337
sensor protein QseC; Provisional
 172-429 7.61e-43

sensor protein QseC; Provisional


Pssm-ID: 182388 [Multi-domain]  Cd Length: 449  Bit Score: 156.35  E-value: 7.61e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489200333 172 GQGLAPLKRIRDALTRRGADSLEPLELAALPSELKPLVETQNQLFQRIAQAIERERRLTGDAAHELRSPLTAIKTHLQVA 251
Cdd:PRK10337 183 GRELAPLKKLALALRMRDPDSETPLNATGVPSEVRPLVEALNQLFARTHAMMVRERRFTSDAAHELRSPLAALKVQTEVA 262

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489200333 252 RMT--EGAAAEQALAHAEEGADRLHRTLDQLLLLARVEGSLSFDDGVQCSAEDAARVAMHDA-GHGDERMFELRLADGLS 328
Cdd:PRK10337 263 QLSddDPQARKKALLQLHAGIDRATRLVDQLLTLSRLDSLDNLQDVAEIPLEDLLQSAVMDIyHTAQQAGIDVRLTLNAH 342

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489200333 329 EAPLEVPSVLAIAALRNLLDNALRHTAAGTRVELAVETEqgcaRFHVRDHGPGIAEADLPHLTRRFWR--HGKSGGSGLG 406
Cdd:PRK10337 343 PVIRTGQPLLLSLLVRNLLDNAIRYSPQGSVVDVTLNAR----NFTVRDNGPGVTPEALARIGERFYRppGQEATGSGLG 418

                        250       260
                 ....*....|....*....|...
gi 489200333 407 LAIVQAIVQRCQCRLDFDSRADG 429
Cdd:PRK10337 419 LSIVRRIAKLHGMNVSFGNAPEG 441
BaeS COG0642
Signal transduction histidine kinase [Signal transduction mechanisms];
118-439 5.98e-34

Signal transduction histidine kinase [Signal transduction mechanisms];


Pssm-ID: 440407 [Multi-domain]  Cd Length: 328  Bit Score: 129.64  E-value: 5.98e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489200333 118 VLWRSFTVQAGDLRVSTADRLEERDVLQRSVVVAAAVPVTVALLGSLALLWLGAGQGLAPLKRIRDALTRRGADSLEPLE 197
Cdd:COG0642    2 LLLLLLLVLLLLLLLLLLLALLLLLLLLLLLALLLLLALLLLLLLLLLLLLLLALALLALLLLLLLLLLLLLLLLLLLLL 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489200333 198 LAALPSELKPLVETQNQLFQRIAQAIERERRLTGDAAHELRSPLTAIKTHLQVARMTEGAAAEQALAHAEEGADRLHRTL 277
Cdd:COG0642   82 LLLLLLLLLLLLLLLLALLLLLEEANEAKSRFLANVSHELRTPLTAIRGYLELLLEELDEEQREYLETILRSADRLLRLI 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489200333 278 DQLLLLARVEGSLSFDDGVQCSAEDAARVAMHDAGHGDER---MFELRLADGLseAPLEVPSVLAIAALRNLLDNALRHT 354
Cdd:COG0642  162 NDLLDLSRLEAGKLELEPEPVDLAELLEEVVELFRPLAEEkgiELELDLPDDL--PTVRGDPDRLRQVLLNLLSNAIKYT 239

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489200333 355 AAGTRVELAVETEQGCARFHVRDHGPGIAEADLPHLTRRFWRHGKSGGSGLG---LAIVQAIVQRCQCRLDFDSRAD-GL 430
Cdd:COG0642  240 PEGGTVTVSVRREGDRVRISVEDTGPGIPPEDLERIFEPFFRTDPSRRGGGTglgLAIVKRIVELHGGTIEVESEPGkGT 319


                 ....*....
gi 489200333 431 RVTLEMPLR 439
Cdd:COG0642  320 TFTVTLPLA 328
cztS_silS_copS TIGR01386
heavy metal sensor kinase; Members of this family contain a sensor histidine kinase domain ...
 1-415 4.61e-29

heavy metal sensor kinase; Members of this family contain a sensor histidine kinase domain (pfam00512) and a domain found in bacterial signal proteins (pfam00672). This group is separated phylogenetically from related proteins with similar architecture and contains a number of proteins associated with heavy metal resistance efflux systems for copper, silver, cadmium, and/or zinc.


Pssm-ID: 273593 [Multi-domain]  Cd Length: 457  Bit Score: 118.26  E-value: 4.61e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489200333    1 MSLRLRLTLILGSAFILLWSLAAAWMLCDLRGQMMR----SFDQRLAASARMVAGLLQQLPQPQPADGQTTRLSAEQ--- 73
Cdd:TIGR01386   2 RSLTLRLALLFAAVTALVFALSGFMLYSSLERHFEErdreELQGKLEQVRRFLRDPADLDEDIKRLQEKIDDLLVGHsdl 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489200333   74 -LGIPNGMACQVSSLRGEVLAQSHATPERALDSTASGFRDQEINGVLWRSFTV-----QAGDLRVSTADRLEERDVLQRS 147
Cdd:TIGR01386  82 aLSILNPDGRLLFERAQGAALVPAVAANDALLELDQADAKMTHYRSILRSVAAlpggkGRKPVQITVALDINAHTHLLDA 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489200333  148 VVVAAAVPVTVALLGSLALLWLGAGQGLAPLKRIRDALTRRGADSLE-PLELAALPSELKPLVETQNQLFQRIAQAIERE 226
Cdd:TIGR01386 162 LRKWLILIAVLLVLLTALLGWWITRLGLEPLRRLSAVAARISPESLDqRLDPSRAPAELRELAQSFNAMLGRLEDAFQRL 241

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489200333  227 RRLTGDAAHELRSPLTAIKTHLQVA--RMTEGAAAEQALAHAEEGADRLHRTLDQLLLLARVE-GSLSFDDGVQCSAEDA 303
Cdd:TIGR01386 242 SQFSADLAHELRTPLTNLLGQTQVAlsQPRTGEEYREVLESNLEELERLSRMVSDMLFLARADnGQLALERVRLDLAAEL 321

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489200333  304 ARVAMHDAGHGDERMFELRLAdglSEAPLEVPSVLAIAALRNLLDNALRHTAAGTRVELAVETEQGCARFHVRDHGPGIA 383
Cdd:TIGR01386 322 AKVAEYFEPLAEERGVRIRVE---GEGLVRGDPQMFRRAISNLLSNALRHTPDGGTITVRIERRSDEVRVSVSNPGPGIP 398

                         410       420       430
                  ....*....|....*....|....*....|....*..
gi 489200333  384 EADLPHLTRRFWR-----HGKSGGSGLGLAIVQAIVQ 415
Cdd:TIGR01386 399 PEHLSRLFDRFYRvdparSNSGEGTGLGLAIVRSIME 435
HATPase cd00075
Histidine kinase-like ATPase domain; This superfamily includes the histidine kinase-like ...
 342-435 1.54e-19

Histidine kinase-like ATPase domain; This superfamily includes the histidine kinase-like ATPase (HATPase) domains of several ATP-binding proteins such as histidine kinase, DNA gyrase B, topoisomerases, heat shock protein 90 (HSP90), phytochrome-like ATPases and DNA mismatch repair proteins. Domains belonging to this superfamily are also referred to as GHKL (gyrase, heat-shock protein 90, histidine kinase, MutL) ATPase domains.


Pssm-ID: 340391 [Multi-domain]  Cd Length: 102  Bit Score: 83.42  E-value: 1.54e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489200333 342 ALRNLLDNALRHTAAGTRVELAVETEQGCARFHVRDHGPGIAEADLPHLTRRFWRHGKSGGSGLG---LAIVQAIVQRCQ 418
Cdd:cd00075    4 VLSNLLDNALKYSPPGGTIEISLRQEGDGVVLEVEDNGPGIPEEDLERIFERFYRGDKSREGGGTglgLAIVRRIVEAHG 83

                         90
                 ....*....|....*...
gi 489200333 419 CRLDFDSRAD-GLRVTLE 435
Cdd:cd00075   84 GRITVESEPGgGTTFTVT 101
HATPase_c smart00387
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
 342-439 1.64e-18

Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.


Pssm-ID: 214643 [Multi-domain]  Cd Length: 111  Bit Score: 80.77  E-value: 1.64e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489200333   342 ALRNLLDNALRHTAAGTRVELAVETEQGCARFHVRDHGPGIAEADLPHLTRRFWRHGKSGGSGLGL----AIVQAIVQRC 417
Cdd:smart00387   9 VLSNLLDNAIKYTPEGGRITVTLERDGDHVEITVEDNGPGIPPEDLEKIFEPFFRTDKRSRKIGGTglglSIVKKLVELH 88

                           90       100
                   ....*....|....*....|...
gi 489200333   418 QCRLDFDSRAD-GLRVTLEMPLR 439
Cdd:smart00387  89 GGEISVESEPGgGTTFTITLPLE 111
HATPase_c pfam02518
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the ...
 342-440 1.45e-15

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.


Pssm-ID: 460579 [Multi-domain]  Cd Length: 109  Bit Score: 72.40  E-value: 1.45e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489200333  342 ALRNLLDNALRHTAAGTRVELAVETEqGCARFHVRDHGPGIAEADLPHLTRRFWRHGKSGGSGLGL--AIVQAIVQRCQC 419
Cdd:pfam02518   9 VLSNLLDNALKHAAKAGEITVTLSEG-GELTLTVEDNGIGIPPEDLPRIFEPFSTADKRGGGGTGLglSIVRKLVELLGG 87

                          90       100
                  ....*....|....*....|..
gi 489200333  420 RLDFDSRAD-GLRVTLEMPLRE 440
Cdd:pfam02518  88 TITVESEPGgGTTVTLTLPLAQ 109
MtrAB_MtrB NF040691
MtrAB system histidine kinase MtrB;
226-396 7.89e-07

MtrAB system histidine kinase MtrB;


Pssm-ID: 468655 [Multi-domain]  Cd Length: 507  Bit Score: 51.18  E-value: 7.89e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489200333 226 ERRLTGDAAHELRSPLTAIKTHLQV---ARMTEGAAAEQALAHAEEGADRLHRTLDQLLLLARvegslsFDDG-VQCSAE 301
Cdd:NF040691 271 QQRFVSDVSHELRTPLTTIRMAADVihdSRDDFDPATARSAELLHTELDRFESLLSDLLEISR------FDAGaAELDVE 344

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489200333 302 DA-----ARVAMHDAGHGDERM-FELRLadglseaplEVPSVLAIA---------ALRNLLDNALRHtAAGTRVELAVET 366
Cdd:NF040691 345 PVdlrplVRRVVDALRQLAERAgVELRV---------DAPGTPVVAevdprrverVLRNLVVNAIEH-GEGKPVVVTVAQ 414

                        170       180       190
                 ....*....|....*....|....*....|
gi 489200333 367 EQGCARFHVRDHGPGIAEADLPHLTRRFWR 396
Cdd:NF040691 415 DDTAVAVTVRDHGVGLKPGEVALVFDRFWR 444
2CSK_N pfam08521
Two-component sensor kinase N-terminal; This domain is found in bacterial two-component sensor ...
 16-146 6.51e-06

Two-component sensor kinase N-terminal; This domain is found in bacterial two-component sensor kinases towards the N-terminus. It recognizes Autoinducer 3 (AI-3), epinephrine, norepineprhine and Fe(III) (Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).


Pssm-ID: 430051  Cd Length: 142  Bit Score: 45.71  E-value: 6.51e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489200333   16 ILLWSLAAAWMLCDLRGQMMRSFDQRLAASARMVAGLLQQLPQPQPADgqTTRLSAEQLGIPNG--MACQVSSLRGEVLA 93
Cdd:pfam08521   2 LLLWLLSAAITYRVARNAANRAYDRALLASARALAEQVRVEDGELQVD--LPPAALEMLRADAEdrVYYQVLDPDGRLLA 79

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 489200333   94 QSHATPERALDSTASGFRDQEINGVLWRSFTV--------QAGDLRVSTADRLEERDVLQR 146
Cdd:pfam08521  80 GDADLPLPPGYAGEPRFYDAEYRGEPVRVAALarplagpgASGPVLVQVAETLEKRDALAR 140
 
Name Accession Description Interval E-value
PRK10337 PRK10337
sensor protein QseC; Provisional
 172-429 7.61e-43

sensor protein QseC; Provisional


Pssm-ID: 182388 [Multi-domain]  Cd Length: 449  Bit Score: 156.35  E-value: 7.61e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489200333 172 GQGLAPLKRIRDALTRRGADSLEPLELAALPSELKPLVETQNQLFQRIAQAIERERRLTGDAAHELRSPLTAIKTHLQVA 251
Cdd:PRK10337 183 GRELAPLKKLALALRMRDPDSETPLNATGVPSEVRPLVEALNQLFARTHAMMVRERRFTSDAAHELRSPLAALKVQTEVA 262

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489200333 252 RMT--EGAAAEQALAHAEEGADRLHRTLDQLLLLARVEGSLSFDDGVQCSAEDAARVAMHDA-GHGDERMFELRLADGLS 328
Cdd:PRK10337 263 QLSddDPQARKKALLQLHAGIDRATRLVDQLLTLSRLDSLDNLQDVAEIPLEDLLQSAVMDIyHTAQQAGIDVRLTLNAH 342

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489200333 329 EAPLEVPSVLAIAALRNLLDNALRHTAAGTRVELAVETEqgcaRFHVRDHGPGIAEADLPHLTRRFWR--HGKSGGSGLG 406
Cdd:PRK10337 343 PVIRTGQPLLLSLLVRNLLDNAIRYSPQGSVVDVTLNAR----NFTVRDNGPGVTPEALARIGERFYRppGQEATGSGLG 418

                        250       260
                 ....*....|....*....|...
gi 489200333 407 LAIVQAIVQRCQCRLDFDSRADG 429
Cdd:PRK10337 419 LSIVRRIAKLHGMNVSFGNAPEG 441
BaeS COG0642
Signal transduction histidine kinase [Signal transduction mechanisms];
118-439 5.98e-34

Signal transduction histidine kinase [Signal transduction mechanisms];


Pssm-ID: 440407 [Multi-domain]  Cd Length: 328  Bit Score: 129.64  E-value: 5.98e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489200333 118 VLWRSFTVQAGDLRVSTADRLEERDVLQRSVVVAAAVPVTVALLGSLALLWLGAGQGLAPLKRIRDALTRRGADSLEPLE 197
Cdd:COG0642    2 LLLLLLLVLLLLLLLLLLLALLLLLLLLLLLALLLLLALLLLLLLLLLLLLLLALALLALLLLLLLLLLLLLLLLLLLLL 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489200333 198 LAALPSELKPLVETQNQLFQRIAQAIERERRLTGDAAHELRSPLTAIKTHLQVARMTEGAAAEQALAHAEEGADRLHRTL 277
Cdd:COG0642   82 LLLLLLLLLLLLLLLLALLLLLEEANEAKSRFLANVSHELRTPLTAIRGYLELLLEELDEEQREYLETILRSADRLLRLI 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489200333 278 DQLLLLARVEGSLSFDDGVQCSAEDAARVAMHDAGHGDER---MFELRLADGLseAPLEVPSVLAIAALRNLLDNALRHT 354
Cdd:COG0642  162 NDLLDLSRLEAGKLELEPEPVDLAELLEEVVELFRPLAEEkgiELELDLPDDL--PTVRGDPDRLRQVLLNLLSNAIKYT 239

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489200333 355 AAGTRVELAVETEQGCARFHVRDHGPGIAEADLPHLTRRFWRHGKSGGSGLG---LAIVQAIVQRCQCRLDFDSRAD-GL 430
Cdd:COG0642  240 PEGGTVTVSVRREGDRVRISVEDTGPGIPPEDLERIFEPFFRTDPSRRGGGTglgLAIVKRIVELHGGTIEVESEPGkGT 319


                 ....*....
gi 489200333 431 RVTLEMPLR 439
Cdd:COG0642  320 TFTVTLPLA 328
WalK COG5002
Sensor histidine kinase WalK [Signal transduction mechanisms];
67-440 4.49e-31

Sensor histidine kinase WalK [Signal transduction mechanisms];


Pssm-ID: 444026 [Multi-domain]  Cd Length: 390  Bit Score: 123.12  E-value: 4.49e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489200333  67 TRLSAEQLGIPNGMACQVSSLRGEVLAQSHATPERALDSTASGFRDQEINGVLWRSFTVQAGDLRVSTADRLEERDVLQR 146
Cdd:COG5002    6 LLLLALLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLALLLLLLLLLLLLLALLLLLLLLLLLLALALLL 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489200333 147 SVVVAAAVPVTVALLGSLALLWLGAGQGLAPLKRIRDALTRRGADSLEPLELAALPSELKPLVETQNQLFQRIAQAIERE 226
Cdd:COG5002   86 LALLLLLLLLLLLLALLILLLLLALLILLAALLLLLSELLLLLLLLGRLSLRLSALLLGLLLLAAVERDITELERLEQMR 165

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489200333 227 RRLTGDAAHELRSPLTAIKTHLQVARMTEGAAAEQALAHA---EEGADRLHRTLDQLLLLARVE-GSLSFD-DGVQCSA- 300
Cdd:COG5002  166 REFVANVSHELRTPLTSIRGYLELLLDGAADDPEERREYLeiiLEEAERLSRLVNDLLDLSRLEsGELKLEkEPVDLAEl 245

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489200333 301 -EDAARVAMHDAghgDERMFELRLadglsEAPLEVPSVLAIA-----ALRNLLDNALRHTAAGTRVELAVETEQGCARFH 374
Cdd:COG5002  246 lEEVVEELRPLA---EEKGIELEL-----DLPEDPLLVLGDPdrleqVLTNLLDNAIKYTPEGGTITVSLREEDDQVRIS 317

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 489200333 375 VRDHGPGIAEADLPHLTRRFWRHGKSGGSGLG-----LAIVQAIVQRCQCRLDFDSRAD-GLRVTLEMPLRE 440
Cdd:COG5002  318 VRDTGIGIPEEDLPRIFERFYRVDKSRSRETGgtglgLAIVKHIVEAHGGRIWVESEPGkGTTFTITLPLAR 389
KdpD COG2205
K+-sensing histidine kinase KdpD [Signal transduction mechanisms];
217-440 6.68e-31

K+-sensing histidine kinase KdpD [Signal transduction mechanisms];


Pssm-ID: 441807 [Multi-domain]  Cd Length: 239  Bit Score: 118.86  E-value: 6.68e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489200333 217 QRIAQAIERERRLTGDAAHELRSPLTAIKTHLQVARMTEGAAAEQAL---AHAEEGADRLHRTLDQLLLLARVE-GSLSF 292
Cdd:COG2205    7 EELEELERLKSEFLANVSHELRTPLTSILGAAELLLDEEDLSPEERRellEIIRESAERLLRLIEDLLDLSRLEsGKLSL 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489200333 293 DDGVQCSAEDAARVAMHDAGHGDERMFELRLADGLSEAPLEVPSVLAIAALRNLLDNALRHTAAGTRVELAVETEQGCAR 372
Cdd:COG2205   87 ELEPVDLAELLEEAVEELRPLAEEKGIRLELDLPPELPLVYADPELLEQVLANLLDNAIKYSPPGGTITISARREGDGVR 166

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 489200333 373 FHVRDHGPGIAEADLPHLTRRFWRHGKSGGSGLG---LAIVQAIVQRCQCRLDFDSRAD-GLRVTLEMPLRE 440
Cdd:COG2205  167 ISVSDNGPGIPEEELERIFERFYRGDNSRGEGGTglgLAIVKRIVEAHGGTIWVESEPGgGTTFTVTLPLAE 238
cztS_silS_copS TIGR01386
heavy metal sensor kinase; Members of this family contain a sensor histidine kinase domain ...
 1-415 4.61e-29

heavy metal sensor kinase; Members of this family contain a sensor histidine kinase domain (pfam00512) and a domain found in bacterial signal proteins (pfam00672). This group is separated phylogenetically from related proteins with similar architecture and contains a number of proteins associated with heavy metal resistance efflux systems for copper, silver, cadmium, and/or zinc.


Pssm-ID: 273593 [Multi-domain]  Cd Length: 457  Bit Score: 118.26  E-value: 4.61e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489200333    1 MSLRLRLTLILGSAFILLWSLAAAWMLCDLRGQMMR----SFDQRLAASARMVAGLLQQLPQPQPADGQTTRLSAEQ--- 73
Cdd:TIGR01386   2 RSLTLRLALLFAAVTALVFALSGFMLYSSLERHFEErdreELQGKLEQVRRFLRDPADLDEDIKRLQEKIDDLLVGHsdl 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489200333   74 -LGIPNGMACQVSSLRGEVLAQSHATPERALDSTASGFRDQEINGVLWRSFTV-----QAGDLRVSTADRLEERDVLQRS 147
Cdd:TIGR01386  82 aLSILNPDGRLLFERAQGAALVPAVAANDALLELDQADAKMTHYRSILRSVAAlpggkGRKPVQITVALDINAHTHLLDA 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489200333  148 VVVAAAVPVTVALLGSLALLWLGAGQGLAPLKRIRDALTRRGADSLE-PLELAALPSELKPLVETQNQLFQRIAQAIERE 226
Cdd:TIGR01386 162 LRKWLILIAVLLVLLTALLGWWITRLGLEPLRRLSAVAARISPESLDqRLDPSRAPAELRELAQSFNAMLGRLEDAFQRL 241

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489200333  227 RRLTGDAAHELRSPLTAIKTHLQVA--RMTEGAAAEQALAHAEEGADRLHRTLDQLLLLARVE-GSLSFDDGVQCSAEDA 303
Cdd:TIGR01386 242 SQFSADLAHELRTPLTNLLGQTQVAlsQPRTGEEYREVLESNLEELERLSRMVSDMLFLARADnGQLALERVRLDLAAEL 321

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489200333  304 ARVAMHDAGHGDERMFELRLAdglSEAPLEVPSVLAIAALRNLLDNALRHTAAGTRVELAVETEQGCARFHVRDHGPGIA 383
Cdd:TIGR01386 322 AKVAEYFEPLAEERGVRIRVE---GEGLVRGDPQMFRRAISNLLSNALRHTPDGGTITVRIERRSDEVRVSVSNPGPGIP 398

                         410       420       430
                  ....*....|....*....|....*....|....*..
gi 489200333  384 EADLPHLTRRFWR-----HGKSGGSGLGLAIVQAIVQ 415
Cdd:TIGR01386 399 PEHLSRLFDRFYRvdparSNSGEGTGLGLAIVRSIME 435
PRK10755 PRK10755
two-component system sensor histidine kinase PmrB;
177-437 2.47e-27

two-component system sensor histidine kinase PmrB;


Pssm-ID: 236751 [Multi-domain]  Cd Length: 356  Bit Score: 111.98  E-value: 2.47e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489200333 177 PLKRIRDALTRRGADSLEPLELAALPSELKPLVETQNQLFQRIAQAIERERRLTGDAAHELRSPLTAIKTHLQ------- 249
Cdd:PRK10755  88 PLAELQKELEARTADNLTPIAIHSSTLEIEAVTSALNQLVSRLTSTLDQERLFTADVAHELRTPLAGIRLHLEllekqhh 167

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489200333 250 ------VARMtegaaaeqalahaeegaDRLHRTLDQLLLLARVEGSLS---------FDDGVQCSAEDAArvAMHDAghg 314
Cdd:PRK10755 168 idvaplIARL-----------------DQMMHTVEQLLQLARAGQSFSsghyqtvklLEDVILPSQDELS--EMLEQ--- 225

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489200333 315 deRMFELRLADGLSEAPLEVPSVLAIAALRNLLDNALRHTAAGTRVELAVETEQGCARFHVRDHGPGIAEADLPHLTRRF 394
Cdd:PRK10755 226 --RQQTLLLPESAADITVQGDATLLRLLLRNLVENAHRYSPEGSTITIKLSQEDGGAVLAVEDEGPGIDESKCGELSKAF 303

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
gi 489200333 395 WR-HGKSGGSGLGLAIVQAIVQRCQCRLDFDSRAD--GLRVTLEMP 437
Cdd:PRK10755 304 VRmDSRYGGIGLGLSIVSRITQLHHGQFFLQNRQErsGTRAWVWLP 349
HATPase cd00075
Histidine kinase-like ATPase domain; This superfamily includes the histidine kinase-like ...
 342-435 1.54e-19

Histidine kinase-like ATPase domain; This superfamily includes the histidine kinase-like ATPase (HATPase) domains of several ATP-binding proteins such as histidine kinase, DNA gyrase B, topoisomerases, heat shock protein 90 (HSP90), phytochrome-like ATPases and DNA mismatch repair proteins. Domains belonging to this superfamily are also referred to as GHKL (gyrase, heat-shock protein 90, histidine kinase, MutL) ATPase domains.


Pssm-ID: 340391 [Multi-domain]  Cd Length: 102  Bit Score: 83.42  E-value: 1.54e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489200333 342 ALRNLLDNALRHTAAGTRVELAVETEQGCARFHVRDHGPGIAEADLPHLTRRFWRHGKSGGSGLG---LAIVQAIVQRCQ 418
Cdd:cd00075    4 VLSNLLDNALKYSPPGGTIEISLRQEGDGVVLEVEDNGPGIPEEDLERIFERFYRGDKSREGGGTglgLAIVRRIVEAHG 83

                         90
                 ....*....|....*...
gi 489200333 419 CRLDFDSRAD-GLRVTLE 435
Cdd:cd00075   84 GRITVESEPGgGTTFTVT 101
HATPase_c smart00387
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
 342-439 1.64e-18

Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.


Pssm-ID: 214643 [Multi-domain]  Cd Length: 111  Bit Score: 80.77  E-value: 1.64e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489200333   342 ALRNLLDNALRHTAAGTRVELAVETEQGCARFHVRDHGPGIAEADLPHLTRRFWRHGKSGGSGLGL----AIVQAIVQRC 417
Cdd:smart00387   9 VLSNLLDNAIKYTPEGGRITVTLERDGDHVEITVEDNGPGIPPEDLEKIFEPFFRTDKRSRKIGGTglglSIVKKLVELH 88

                           90       100
                   ....*....|....*....|...
gi 489200333   418 QCRLDFDSRAD-GLRVTLEMPLR 439
Cdd:smart00387  89 GGEISVESEPGgGTTFTITLPLE 111
HATPase_c pfam02518
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the ...
 342-440 1.45e-15

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.


Pssm-ID: 460579 [Multi-domain]  Cd Length: 109  Bit Score: 72.40  E-value: 1.45e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489200333  342 ALRNLLDNALRHTAAGTRVELAVETEqGCARFHVRDHGPGIAEADLPHLTRRFWRHGKSGGSGLGL--AIVQAIVQRCQC 419
Cdd:pfam02518   9 VLSNLLDNALKHAAKAGEITVTLSEG-GELTLTVEDNGIGIPPEDLPRIFEPFSTADKRGGGGTGLglSIVRKLVELLGG 87

                          90       100
                  ....*....|....*....|..
gi 489200333  420 RLDFDSRAD-GLRVTLEMPLRE 440
Cdd:pfam02518  88 TITVESEPGgGTTVTLTLPLAQ 109
PRK11100 PRK11100
sensory histidine kinase CreC; Provisional
 218-439 9.22e-15

sensory histidine kinase CreC; Provisional


Pssm-ID: 236846 [Multi-domain]  Cd Length: 475  Bit Score: 76.04  E-value: 9.22e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489200333 218 RIAQAIERER-RLTGDA---------AHELRSPLTAIK----------THLQVARMTEGAAAEqalahaeegADRLHRTL 277
Cdd:PRK11100 238 ELAQALESMRvKLEGKAyveqyvqtlTHELKSPLAAIRgaaellqedpPPEDRARFTGNILTQ---------SARLQQLI 308

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489200333 278 DQLLLLARVEGSLSFDDGVQCS-----AEDAARVAMHDAGHGdermfeLRLADGLSEAPLEVPSVLAIAALRNLLDNALR 352
Cdd:PRK11100 309 DRLLELARLEQRQELEVLEPVAlaallEELVEAREAQAAAKG------ITLRLRPDDARVLGDPFLLRQALGNLLDNAID 382

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489200333 353 HTAAGTRVELAVETEQGCARFHVRDHGPGIAEADLPHLTRRFW----RHGKSGGSGLGLAIVQAIVQRCQCRLDFDSRAD 428
Cdd:PRK11100 383 FSPEGGTITLSAEVDGEQVALSVEDQGPGIPDYALPRIFERFYslprPANGRKSTGLGLAFVREVARLHGGEVTLRNRPE 462

                        250
                 ....*....|..
gi 489200333 429 -GLRVTLEMPLR 439
Cdd:PRK11100 463 gGVLATLTLPRH 474
HATPase_BasS-like cd16940
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 336-434 1.56e-13

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BasS HK of the BasS-BasR two-component regulatory system (TCS). Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some contain a HAMP sensory domain, while some an N-terminal two-component sensor kinase domain.


Pssm-ID: 340417 [Multi-domain]  Cd Length: 113  Bit Score: 66.66  E-value: 1.56e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489200333 336 SVLAIAALRNLLDNALRHTAAGTRVELAVETEQGcARFHVRDHGPGIAEADLPHLTRRFWRHGKSGGSGL--GLAIVQAI 413
Cdd:cd16940   11 ALLLFLLLRNLVDNAVRYSPQGSRVEIKLSADDG-AVIRVEDNGPGIDEEELEALFERFYRSDGQNYGGSglGLSIVKRI 89

                         90       100
                 ....*....|....*....|..
gi 489200333 414 VQRCQCRLDF-DSRADGLRVTL 434
Cdd:cd16940   90 VELHGGQIFLgNAQGGGLEAWV 111
COG4191 COG4191
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal ...
 129-438 1.60e-13

Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms];


Pssm-ID: 443345 [Multi-domain]  Cd Length: 361  Bit Score: 71.37  E-value: 1.60e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489200333 129 DLRVSTADRLEERDVLQRSVVVAAAVPVTVALLGSLALLWLGAGQGLAPLKRIRDALTRRGADSLEPLELAALPSELKPL 208
Cdd:COG4191   40 LALLLALLALLLLLLLLLLLLLLELLLLLLALLGGLLRLLLLLGLLLLLLLEALLLLLLAALDAEENAELEELERDITEL 119

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489200333 209 VETQNQLFQRIAQAIERER-----RLTGDAAHELRSPLTAIKTHLQVARMT-----EGAAAEQALAHAEEGADRLHRTLD 278
Cdd:COG4191  120 ERAEEELRELQEQLVQSEKlaalgELAAGIAHEINNPLAAILGNAELLRRRledepDPEELREALERILEGAERAAEIVR 199

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489200333 279 QLLLLARVEGS----LSFDDGVqcsaEDAARVAMHDAGHGDERMfELRLADGLseaplevPSVLAIA-----ALRNLLDN 349
Cdd:COG4191  200 SLRAFSRRDEEerepVDLNELI----DEALELLRPRLKARGIEV-ELDLPPDL-------PPVLGDPgqleqVLLNLLIN 267

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489200333 350 ---ALRHTAAGtRVELAVETEQGCARFHVRDHGPGIAEADLPHL------TRRfwrhgksggsgLGL------AIVQAIV 414
Cdd:COG4191  268 aidAMEEGEGG-RITISTRREGDYVVISVRDNGPGIPPEVLERIfepfftTKP-----------VGKgtglglSISYGIV 335

                        330       340
                 ....*....|....*....|....*
gi 489200333 415 QRCQCRLDFDSRAD-GLRVTLEMPL 438
Cdd:COG4191  336 EKHGGRIEVESEPGgGTTFTITLPL 360
PRK09835 PRK09835
Cu(+)/Ag(+) sensor histidine kinase;
173-440 3.01e-13

Cu(+)/Ag(+) sensor histidine kinase;


Pssm-ID: 182101 [Multi-domain]  Cd Length: 482  Bit Score: 71.34  E-value: 3.01e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489200333 173 QGLAPLKRIRDALTRRGADSLEP-LELAALPSELKPLVETQNQLFQRIAQAIERERRLTGDAAHELRSPLTAIKTHLQVA 251
Cdd:PRK09835 208 KGHAPIRSVSRQIQNITSKDLDVrLDPQTVPIELEQLVLSFNHMIERIEDVFTRQSNFSADIAHEIRTPITNLITQTEIA 287

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489200333 252 rMTEGAAAEQALAHAEEGAD---RLHRTLDQLLLLARVEGSLSFDDGVQCS-AEDAARVAMHDAGHGDERMFELRLaDGL 327
Cdd:PRK09835 288 -LSQSRSQKELEDVLYSNLEeltRMAKMVSDMLFLAQADNNQLIPEKKMLDlADEVGKVFDFFEAWAEERGVELRF-VGD 365

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489200333 328 SEAPLEVPSVLAiAALRNLLDNALRHTAAGTRVELAVETEQGCARFHVRDHGPGIAEADLPHLTRRFW-----RHGKSGG 402
Cdd:PRK09835 366 PCQVAGDPLMLR-RAISNLLSNALRYTPAGEAITVRCQEVDHQVQLVVENPGTPIAPEHLPRLFDRFYrvdpsRQRKGEG 444

                        250       260       270
                 ....*....|....*....|....*....|....*...
gi 489200333 403 SGLGLAIVQAIVQRCQCRLDFDSRADGLRVTLEMPLRE 440
Cdd:PRK09835 445 SGIGLAIVKSIVVAHKGTVAVTSDARGTRFVISLPRLE 482
phoR PRK11006
phosphate regulon sensor histidine kinase PhoR;
235-396 5.10e-12

phosphate regulon sensor histidine kinase PhoR;


Pssm-ID: 182895 [Multi-domain]  Cd Length: 430  Bit Score: 67.34  E-value: 5.10e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489200333 235 HELRSPLTAIKTHLQvarMT-----EGAAAEQALAHAEEGADRLHRTLDQLLLLARVEGSLSFDDGVQCSAEDAARVAMH 309
Cdd:PRK11006 213 HELRTPLTVLQGYLE---MMqdqplEGALREKALHTMREQTQRMEGLVKQLLTLSKIEAAPTIDLNEKVDVPMMLRVLER 289

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489200333 310 DAghgdermfeLRLADGLSEAPLEVPSVLAI--------AALRNLLDNALRHTAAGTRVELA-VETEQGcARFHVRDHGP 380
Cdd:PRK11006 290 EA---------QTLSQGKHTITFEVDNSLKVfgnedqlrSAISNLVYNAVNHTPEGTHITVRwQRVPQG-AEFSVEDNGP 359

                        170
                 ....*....|....*.
gi 489200333 381 GIAEADLPHLTRRFWR 396
Cdd:PRK11006 360 GIAPEHIPRLTERFYR 375
NtrY COG5000
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism ...
 215-440 1.89e-11

Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms];


Pssm-ID: 444024 [Multi-domain]  Cd Length: 422  Bit Score: 65.37  E-value: 1.89e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489200333 215 LFQRIAQAIERER-----RLTGDAAHELRSPLTAIKTHLQVARMTEGAAAEQALAHAEEG-------ADRLHRTLDQLLL 282
Cdd:COG5000  185 VFDDITELLRAERlaawgELARRIAHEIKNPLTPIQLSAERLRRKLADKLEEDREDLERAldtiirqVDRLKRIVDEFLD 264

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489200333 283 LARVE----GSLSFDDGVQcsaedAARVAMHDAGHGDERMFELRLADGLseaplevPSVLAIA-----ALRNLLDNALRH 353
Cdd:COG5000  265 FARLPepqlEPVDLNELLR-----EVLALYEPALKEKDIRLELDLDPDL-------PEVLADRdqleqVLINLLKNAIEA 332

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489200333 354 TAAGTRVELAVETEQGCARFHVRDHGPGIAEADLPHLTRRFwrhgksggsglglAIVQAIVQRCQCRLDFDSRAD-GLRV 432
Cdd:COG5000  333 IEEGGEIEVSTRREDGRVRIEVSDNGPGIPEEVLERIFEPFfttkpk-gtglglAIVKKIVEEHGGTIELESRPGgGTTF 411


                 ....*...
gi 489200333 433 TLEMPLRE 440
Cdd:COG5000  412 TIRLPLAE 419
COG4251 COG4251
Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal ...
 3-396 1.78e-10

Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms];


Pssm-ID: 443393 [Multi-domain]  Cd Length: 503  Bit Score: 62.88  E-value: 1.78e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489200333   3 LRLRLTLILGSAFILLWSLAAAWMLCDLRGQMMRSFDQRLAASARMVAGLLQQLPQPQPADGQTTRLSAEQLGIPNGMAC 82
Cdd:COG4251   55 LLSLLALLLLLLLLLLLLLVLAALALLLLLLLLELALVLLALLLVLLLLLALLLLLALLLLLELLLLLLALLLLLLLLAL 134

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489200333  83 QVSSLRGEVLAQSHATPERALDSTASGFRDQEINGVLWRSFTVQAGDLRVSTADRLEERDVLQRSVVVAAAVPVTVALLG 162
Cdd:COG4251  135 LLLEELALLRLALALLLLLLLLLLLLLLLLALILALLLAALAELELLLLLLLVLLLLLLLLLLLLLLLLRLLLELLLLLE 214

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489200333 163 SLALLWLGAGQGLAPLKRIRDALTRRGADSLEPLELAALPSELKPLVETQNQLFQRIAQAIERE----RRLTGDAAHELR 238
Cdd:COG4251  215 AELLLSLGGGLGLLLLLLLLLVLLLLLILLLLLLILVLELLELRLELEELEEELEERTAELERSneelEQFAYVASHDLR 294

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489200333 239 SPLTAIKTHLQVARMTEGAAAEQALAHA----EEGADRLHRTLDQLLLLARVE-GSLSFddgVQCSAEDAARVAMHDAGH 313
Cdd:COG4251  295 EPLRKISGFSQLLEEDYGDKLDEEGREYleriRDAAERMQALIDDLLAYSRVGrQELEF---EPVDLNELLEEVLEDLEP 371

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489200333 314 G-DERMFELRLADGlseaplevPSVLAIAAL-----RNLLDNALRHTAAGT--RVELAVETEQGCARFHVRDHGPGIAEA 385
Cdd:COG4251  372 RiEERGAEIEVGPL--------PTVRGDPTLlrqvfQNLISNAIKYSRPGEppRIEIGAEREGGEWVFSVRDNGIGIDPE 443

                        410
                 ....*....|.
gi 489200333 386 DLPHLTRRFWR 396
Cdd:COG4251  444 YAEKIFEIFQR 454
envZ PRK09467
osmolarity sensor protein; Provisional
 311-440 3.36e-09

osmolarity sensor protein; Provisional


Pssm-ID: 236531 [Multi-domain]  Cd Length: 435  Bit Score: 58.38  E-value: 3.36e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489200333 311 AGHGDERMFELRLADGLSEAPLevpSVLAIA-ALRNLLDNALRHTAAGTRVELAVETEQgcARFHVRDHGPGIAEADLPH 389
Cdd:PRK09467 306 AESGYEREIETALQPGPIEVPM---NPIAIKrALANLVVNAARYGNGWIKVSSGTEGKR--AWFQVEDDGPGIPPEQLKH 380

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 489200333 390 LTRRFWRHGKSGGSG---LGLAIVQAIVQRCQCRLDFDSRAD-GLRVTLEMPLRE 440
Cdd:PRK09467 381 LFQPFTRGDSARGSSgtgLGLAIVKRIVDQHNGKVELGNSEEgGLSARAWLPLTT 435
KinD COG5808
Sporulation sensor histidine kinase D [Cell cycle control, cell division, chromosome ...
 214-440 4.31e-09

Sporulation sensor histidine kinase D [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];


Pssm-ID: 444510 [Multi-domain]  Cd Length: 454  Bit Score: 58.22  E-value: 4.31e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489200333 214 QLFQRIAQAIERERR-----LTGDAAHELRSPLTAIKTHLQVARMTEGAAAEQAL-AHAEEGADRLHRTLDQLLLLARVE 287
Cdd:COG5808  224 TLLERVIQEINTQKLeligtFAASTAHEIRNPLTSIKGFIQLLQEKYPELEDQKYfDIIQEEIQRINQIVSEFLVLGKPT 303

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489200333 288 GSLSFDDGVQCSAEDAARVAMHDA-GHGdermFELRLADGLSEAPLEVPSVLAIAALRNLLDNALRHTAAGTRVELAVET 366
Cdd:COG5808  304 AKKLELDDLNELIEEILSIIDSEAnLKN----IRVEKQSLDEPLHIKCDKDRIKQVLLNLIKNAIEAMKEGGKLTISIEN 379

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 489200333 367 EQGCARFHVRDHGPGIAEADLPHLTRRFWRHgKSGGSGLGLAIVQAIVQRCQCRLDFDSRAD-GLRVTLEMPLRE 440
Cdd:COG5808  380 DDEKAVIEVIDNGEGIPEDIIDEIFEPFVTT-KEGGTGLGLSVCKRIVEMHGGEIDIESEEGkGTTFTIRLPLKK 453
HATPase_EnvZ-like cd16950
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 342-437 4.64e-09

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli EnvZ and Pseudomonas aeruginosa BfmS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli EnvZ of the EnvZ-OmpR two-component regulatory system (TCS), which functions in osmoregulation. It also contains the HATPase domain of Pseudomonas aeruginosa BfmS, the HK of the BfmSR TCS, which functions in the regulation of the rhl quorum-sensing system and bacterial virulence in P. aeruginosa. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a periplasmic domain.


Pssm-ID: 340426 [Multi-domain]  Cd Length: 101  Bit Score: 53.61  E-value: 4.64e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489200333 342 ALRNLLDNALRHtaAGTRVELAVETEQGCARFHVRDHGPGIAEADLPHLTRRFWRHGKSGGSGLG---LAIVQAIVQRCQ 418
Cdd:cd16950    4 VLSNLVDNALRY--GGGWVEVSSDGEGNRTRIQVLDNGPGIAPEEVDELFQPFYRGDNARGTSGTglgLAIVQRISDAHG 81

                         90       100
                 ....*....|....*....|
gi 489200333 419 CRLDFDSRA-DGLRVTLEMP 437
Cdd:cd16950   82 GSLTLANRAgGGLCARIELP 101
HATPase_EcPhoR-like cd16952
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 341-439 6.50e-09

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoR; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli or Vibrio cholera PhoR, the histidine kinase (HK) of PhoB-PhoR a two-component signal transduction system (TCS) involved in phosphate regulation. PhoR monitors extracellular inorganic phosphate (Pi) availability and PhoB, the response regulator, regulates transcription of genes of the phosphate regulon. PhoR is a bifunctional histidine autokinase/phospho-PhoB phosphatase; in phosphate deficiency, it autophosphorylates and Pi is transferred to PhoB, and when environmental Pi is abundant, it removes the phosphoryl group from phosphorylated PhoB. Other roles of PhoB-PhoR TCS have been described, including motility, biofilm formation, intestinal colonization, and virulence in V. cholera. E.coli PhoR and Bacillus subtilis PhoR (whose HATPase domain belongs to a different family) sense very different signals in each bacterium. In E. coli the PhoR signal comes from phosphate transport mediated by the PstSCAB2 phosphate transporter and the PhoU chaperone-like protein while in B. subtilis, the PhoR activation signal comes from wall teichoic acid (WTA) metabolism.


Pssm-ID: 340428 [Multi-domain]  Cd Length: 108  Bit Score: 53.36  E-value: 6.50e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489200333 341 AALRNLLDNALRHTAAGTRVELAVETEQGCARFHVRDHGPGIAEADLPHLTRRFWRHGKSGGSGLG-----LAIVQAIVQ 415
Cdd:cd16952    3 SAFSNLVSNAVKYTPPSDTITVRWSQEESGARLSVEDTGPGIPPEHIPRLTERFYRVDIERCRNTGgtglgLAIVKHVMS 82

                         90       100
                 ....*....|....*....|....*
gi 489200333 416 RCQCRLDFDSR-ADGLRVTLEMPLR 439
Cdd:cd16952   83 RHDARLLIASElGKGSRFTCLFPSS 107
HATPase_CpxA-like cd16949
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 342-438 2.32e-08

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CpxA; This family includes the histidine kinase-like ATPase (HATPase) domains of two-component sensor histidine kinase (HKs) similar to Escherichia coli CpxA, HK of the CpxA-CpxR two-component regulatory system (TCS) which may function in acid stress and in cell wall stability. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a CpxA family periplasmic domain.


Pssm-ID: 340425 [Multi-domain]  Cd Length: 104  Bit Score: 51.56  E-value: 2.32e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489200333 342 ALRNLLDNALRHtaAGTRVELAVETEQGCARFHVRDHGPGIAEADLPHLTRRFWRHGKSGGSGLG-----LAIVQAIVQR 416
Cdd:cd16949    4 ALENVLRNALRY--SPSKILLDISQDGDQWTITITDDGPGVPEDQLEQIFLPFYRVDSARDRESGgtglgLAIAERAIEQ 81

                         90       100
                 ....*....|....*....|...
gi 489200333 417 CQCRLDFDSR-ADGLRVTLEMPL 438
Cdd:cd16949   82 HGGKIKASNRkPGGLRVRIWLPA 104
HATPase_CreC-like cd16945
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 342-434 1.38e-07

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CreC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli CreC of the CreC-CreB two-component regulatory system (TCS) involved in catabolic regulation. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and accessory sensory domain(s) such as HAMP, CACHE or PAS.


Pssm-ID: 340421 [Multi-domain]  Cd Length: 106  Bit Score: 49.38  E-value: 1.38e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489200333 342 ALRNLLDNALRHTAAGTRVELAVETEQGCARFHVRDHGPGIAEADLPHLTRRFWR----HGKSGGSGLGLAIVQAIVQRC 417
Cdd:cd16945    8 AINNLLDNAIDFSPEGGLIALQLEADTEGIELLVFDEGSGIPDYALNRVFERFYSlprpHSGQKSTGLGLAFVQEVAQLH 87

                         90
                 ....*....|....*..
gi 489200333 418 QCRLDFDSRADGLRVTL 434
Cdd:cd16945   88 GGRITLRNRPDGVLAFL 104
CitA COG3290
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction ...
 319-440 3.33e-07

Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction mechanisms];


Pssm-ID: 442519 [Multi-domain]  Cd Length: 389  Bit Score: 52.16  E-value: 3.33e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489200333 319 FELRLADGLSEAPLEVPSVLAIaaLRNLLDNALRHTAAGT----RVELAVETEQGCARFHVRDHGPGIAEADLPHLtrrF 394
Cdd:COG3290  264 LTIDIDSDLPDLPLSDTDLVTI--LGNLLDNAIEAVEKLPeeerRVELSIRDDGDELVIEVEDSGPGIPEELLEKI---F 338

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 489200333 395 WRHGKSGGSGLG---LAIVQAIVQRCQCRLDFDSRAD-GLRVTLEMPLRE 440
Cdd:COG3290  339 ERGFSTKLGEGRglgLALVKQIVEKYGGTIEVESEEGeGTVFTVRLPKEG 388
PRK10604 PRK10604
sensor protein RstB; Provisional
 203-415 3.93e-07

sensor protein RstB; Provisional


Pssm-ID: 236724 [Multi-domain]  Cd Length: 433  Bit Score: 51.91  E-value: 3.93e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489200333 203 SELKPLVETQNQLFQRIAQAIERERRLTGDAAHELRSPLTAIKTHLQvarMTEGAAAEQALAhaeegadrLHRTLDQL-- 280
Cdd:PRK10604 189 SSLERLGVAFNQMADNINALIASKKQLIDGIAHELRTPLVRLRYRLE---MSDNLSAAESQA--------LNRDIGQLea 257

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489200333 281 -----LLLARVEGSlsfDDGVQCSAED-----AARVAMHDAGHgDERMFELRLADglSEAPLEVPSVLAIAALRNLLDNA 350
Cdd:PRK10604 258 lieelLTYARLDRP---QNELHLSEPDlpawlSTHLADIQAVT-PEKTVRLDTPH--QGDYGALDMRLMERVLDNLLNNA 331

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489200333 351 LRHtaAGTRVELAVETEQGCARFHVRDHGPGIAEADLPHLTRRFWRHGKSGGSGL-----GLAIVQAIVQ 415
Cdd:PRK10604 332 LRY--AHSRVRVSLLLDGNQACLIVEDDGPGIPPEERERVFEPFVRLDPSRDRATggcglGLAIVHSIAL 399
MtrAB_MtrB NF040691
MtrAB system histidine kinase MtrB;
226-396 7.89e-07

MtrAB system histidine kinase MtrB;


Pssm-ID: 468655 [Multi-domain]  Cd Length: 507  Bit Score: 51.18  E-value: 7.89e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489200333 226 ERRLTGDAAHELRSPLTAIKTHLQV---ARMTEGAAAEQALAHAEEGADRLHRTLDQLLLLARvegslsFDDG-VQCSAE 301
Cdd:NF040691 271 QQRFVSDVSHELRTPLTTIRMAADVihdSRDDFDPATARSAELLHTELDRFESLLSDLLEISR------FDAGaAELDVE 344

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489200333 302 DA-----ARVAMHDAGHGDERM-FELRLadglseaplEVPSVLAIA---------ALRNLLDNALRHtAAGTRVELAVET 366
Cdd:NF040691 345 PVdlrplVRRVVDALRQLAERAgVELRV---------DAPGTPVVAevdprrverVLRNLVVNAIEH-GEGKPVVVTVAQ 414

                        170       180       190
                 ....*....|....*....|....*....|
gi 489200333 367 EQGCARFHVRDHGPGIAEADLPHLTRRFWR 396
Cdd:NF040691 415 DDTAVAVTVRDHGVGLKPGEVALVFDRFWR 444
HATPase_BaeS-like cd16946
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 343-437 2.47e-06

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BaeS HK of the BaeS/BaeR two-component regulatory system (TCS), which responds to envelope stress. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensory domain.


Pssm-ID: 340422 [Multi-domain]  Cd Length: 109  Bit Score: 45.92  E-value: 2.47e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489200333 343 LRNLLDNALRHTAAGTRVELAVETEQGCARFHVRDHGPGIAEADLPHLTRRFWRHGKSGGSGL-----GLAIVQAIVQRC 417
Cdd:cd16946    9 FVNLLENSLRYTDTGGKLRIRAAQTPQEVRLDVEDSAPGVSDDQLARLFERFYRVESSRNRASggsglGLAICHNIALAH 88

                         90       100
                 ....*....|....*....|.
gi 489200333 418 QCRLDFD-SRADGLRVTLEMP 437
Cdd:cd16946   89 GGTISAEhSPLGGLRLVLTLP 109
NtrB COG3852
Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms];
227-440 2.62e-06

Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms];


Pssm-ID: 443061 [Multi-domain]  Cd Length: 361  Bit Score: 49.07  E-value: 2.62e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489200333 227 RRLTGDAAHELRSPLTAIKTHLQVARM-TEGAAAEQALAHAEEGADRLHRTLDQLLLLARvegslsfDDGVQCSA----- 300
Cdd:COG3852  136 GELAAGLAHEIRNPLTGIRGAAQLLEReLPDDELREYTQLIIEEADRLNNLVDRLLSFSR-------PRPPEREPvnlhe 208

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489200333 301 --EDAARVAMHDAGHGDErmFELRLADGLseaplevPSVLA-----IAALRNLLDNALRHTAAGTRVELAVETEQG---- 369
Cdd:COG3852  209 vlERVLELLRAEAPKNIR--IVRDYDPSL-------PEVLGdpdqlIQVLLNLVRNAAEAMPEGGTITIRTRVERQvtlg 279

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489200333 370 ------CARFHVRDHGPGIAEADLPHL------TRrfwrhgksggsgLG-----LAIVQAIVQRCQCRLDFDSRAD-GLR 431
Cdd:COG3852  280 glrprlYVRIEVIDNGPGIPEEILDRIfepfftTK------------EKgtglgLAIVQKIVEQHGGTIEVESEPGkGTT 347


                 ....*....
gi 489200333 432 VTLEMPLRE 440
Cdd:COG3852  348 FRIYLPLEQ 356
HisKA cd00082
Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed ...
 223-285 4.37e-06

Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-autophosphorylation by the catalytic domain of the histidine kinase. They subsequently transfer the phosphoryl group to the Asp acceptor residue of a response regulator protein. Two-component signalling systems, consisting of a histidine protein kinase that senses a signal input and a response regulator that mediates the output, are ancient and evolutionarily conserved signaling mechanisms in prokaryotes and eukaryotes.


Pssm-ID: 119399 [Multi-domain]  Cd Length: 65  Bit Score: 44.13  E-value: 4.37e-06
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 489200333 223 IERERRLTGDAAHELRSPLTAIKTHLQVARMTEGAAAEQALAHA--EEGADRLHRTLDQLLLLAR 285
Cdd:cd00082    1 LQAKGEFLANVSHELRTPLTAIRGALELLEEELLDDEEQREYLEriREEAERLLRLINDLLDLSR 65
2CSK_N pfam08521
Two-component sensor kinase N-terminal; This domain is found in bacterial two-component sensor ...
 16-146 6.51e-06

Two-component sensor kinase N-terminal; This domain is found in bacterial two-component sensor kinases towards the N-terminus. It recognizes Autoinducer 3 (AI-3), epinephrine, norepineprhine and Fe(III) (Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).


Pssm-ID: 430051  Cd Length: 142  Bit Score: 45.71  E-value: 6.51e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489200333   16 ILLWSLAAAWMLCDLRGQMMRSFDQRLAASARMVAGLLQQLPQPQPADgqTTRLSAEQLGIPNG--MACQVSSLRGEVLA 93
Cdd:pfam08521   2 LLLWLLSAAITYRVARNAANRAYDRALLASARALAEQVRVEDGELQVD--LPPAALEMLRADAEdrVYYQVLDPDGRLLA 79

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 489200333   94 QSHATPERALDSTASGFRDQEINGVLWRSFTV--------QAGDLRVSTADRLEERDVLQR 146
Cdd:pfam08521  80 GDADLPLPPGYAGEPRFYDAEYRGEPVRVAALarplagpgASGPVLVQVAETLEKRDALAR 140
PRK11360 PRK11360
two-component system sensor histidine kinase AtoS;
228-388 8.97e-06

two-component system sensor histidine kinase AtoS;


Pssm-ID: 236901 [Multi-domain]  Cd Length: 607  Bit Score: 48.04  E-value: 8.97e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489200333 228 RLTGDAAHELRSPLTAIKTHLQVAR-MTEGAAAEQALAHAEEGADRLHRTLDQLLLLARVEGSLSFDDGVQCSAEDAARV 306
Cdd:PRK11360 392 ELVAGVAHEIRNPLTAIRGYVQIWRqQTSDPPSQEYLSVVLREVDRLNKVIDQLLEFSRPRESQWQPVSLNALVEEVLQL 471

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489200333 307 aMHDAGHGDERMFELRLADGLSEAPLEvPSVLAiAALRNLLDNALRhtAAGTRVELAVETEQ---GCARFHVRDHGPGIA 383
Cdd:PRK11360 472 -FQTAGVQARVDFETELDNELPPIWAD-PELLK-QVLLNILINAVQ--AISARGKIRIRTWQysdGQVAVSIEDNGCGID 546


                 ....*
gi 489200333 384 EADLP 388
Cdd:PRK11360 547 PELLK 551
HisKA smart00388
His Kinase A (phosphoacceptor) domain; Dimerisation and phosphoacceptor domain of histidine ...
 227-287 9.85e-06

His Kinase A (phosphoacceptor) domain; Dimerisation and phosphoacceptor domain of histidine kinases.


Pssm-ID: 214644 [Multi-domain]  Cd Length: 66  Bit Score: 42.94  E-value: 9.85e-06
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 489200333   227 RRLTGDAAHELRSPLTAIKTHLQVARMTEGAAAEQALAHA-EEGADRLHRTLDQLLLLARVE 287
Cdd:smart00388   3 REFLANLSHELRTPLTAIRGYLELLLDTELSEEQREYLETiLREAERLLRLINDLLDLSRIE 64
KinC COG5807
Sporulation sensor histidine kinase C [Cell cycle control, cell division, chromosome ...
 210-439 1.17e-05

Sporulation sensor histidine kinase C [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];


Pssm-ID: 444509 [Multi-domain]  Cd Length: 358  Bit Score: 47.09  E-value: 1.17e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489200333 210 ETQNQLFQriAQAIERERRLTGDAAHELRSPLTAIKTHLQVAR-MTEGAAAEQALAHAEEGADRLHRTLDQLLLLARveg 288
Cdd:COG5807  133 EAEDKLLR--SEKLSVAGELAAGIAHEIRNPLTSIKGFLQLLQeSREDSEREEYFNIIISEIDRINTIITELLVLSK--- 207

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489200333 289 SLSFDDGVQC---SAEDAARVAMHDAGHGDERmFELRLADGLSEapLEVPSVLAIAALRNLLDNALRHTAAGTRVELAVE 365
Cdd:COG5807  208 PKKFNFKKLNlndVLEDVIALLSTEAILKNIS-IKYDLADDEPV--INGDKNQLKQVFINLIKNAIEAMETGGNITIKTY 284

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 489200333 366 TEQGCARFHVRDHGPGIAEADLPHLTRRFWRHgKSGGSGLGLAIVQAIVQRCQCRLDFDSRA-DGLRVTLEMPLR 439
Cdd:COG5807  285 VEGDFVVISVKDEGIGIPEEVLEKIGEPFFTT-KEEGTGLGLSICKKIIEEHNGTIEVESKPgKGTTFTIYLPLY 358
HATPase_RstB-like cd16939
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 342-396 1.42e-05

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Salmonella typhimurium RstB; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Salmonella typhimurium RstB HK of the RstA-RstB two-component regulatory system (TCS), which regulates expression of the constituents participating in pyrimidine metabolism and iron acquisition, and may be required for regulation of Salmonella motility and invasion. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensor domain.


Pssm-ID: 340416 [Multi-domain]  Cd Length: 104  Bit Score: 43.57  E-value: 1.42e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 489200333 342 ALRNLLDNALRHtaAGTRVELAVETEQGCARFHVRDHGPGIAEADLPHLTRRFWR 396
Cdd:cd16939    4 ALDNLLRNALRY--AHRTVRIALLVSGGRLTLIVEDDGPGIPAAARERVFEPFVR 56
HATPase_SpaK_NisK-like cd16975
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 342-396 2.64e-05

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK. SpaK is the histidine kinase (HK) of the SpaK-SpaR two-component regulatory system (TCS), which is involved in the regulation of the biosynthesis of lantibiotic subtilin. NisK is the HK of the NisK-NisR TCS, which is involved in the regulation of the biosynthesis of lantibiotic nisin. SpaK and NisK may function as membrane-associated protein kinases that phosphorylate SpaR and NisR, respectively, in response to environmental signals.


Pssm-ID: 340434 [Multi-domain]  Cd Length: 107  Bit Score: 43.22  E-value: 2.64e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 489200333 342 ALRNLLDNALRHTAAGTRVELAVETEQGCARFHVRDHGPGIAEADLPHLTRRFWR 396
Cdd:cd16975    8 ALINIISNACQYAPEGGTVSISIYDEEEYLYFEIWDNGHGFSEQDLKKALELFYR 62
HisKA pfam00512
His Kinase A (phospho-acceptor) domain; dimerization and phospho-acceptor domain of histidine ...
 227-287 2.95e-05

His Kinase A (phospho-acceptor) domain; dimerization and phospho-acceptor domain of histidine kinases.


Pssm-ID: 459839 [Multi-domain]  Cd Length: 66  Bit Score: 41.81  E-value: 2.95e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 489200333  227 RRLTGDAAHELRSPLTAIKTHLQVARMTEGAAAEQALAHA-EEGADRLHRTLDQLLLLARVE 287
Cdd:pfam00512   3 SEFLANLSHELRTPLTAIRGYLELLRDEKLDEEQREYLETiLRSAERLLRLINDLLDLSRIE 64
cpxA PRK09470
envelope stress sensor histidine kinase CpxA;
177-438 2.95e-05

envelope stress sensor histidine kinase CpxA;


Pssm-ID: 236532 [Multi-domain]  Cd Length: 461  Bit Score: 46.08  E-value: 2.95e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489200333 177 PLKRIRDALTR--RGADSLEPlELAALPSELKPLVETQNQLFQRIAQAIERERRLTGDAAHELRSPLTaiKTHLQVARMT 254
Cdd:PRK09470 193 PARKLKNAADEvaQGNLRQHP-ELETGPQEFRQAGASFNQMVTALERMMTSQQRLLSDISHELRTPLT--RLQLATALLR 269

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489200333 255 EGAAAEQALAHAEEGADRLHRTLDQLLLLARVEGSLSFDDGVQcSAEDAARVAMHDAGHGDERM-FELRLADGLSEAPLE 333
Cdd:PRK09470 270 RRQGESKELERIETEAQRLDSMINDLLVLSRNQQKNHLERETF-KANSLWSEVLEDAKFEAEQMgKSLTVSAPPGPWPIN 348

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489200333 334 VPSVLAIAALRNLLDNALRHTAagTRVELAVETEQGCARFHVRDHGPGIAEADLPHLTRRFWRHGKSGGSGL-----GLA 408
Cdd:PRK09470 349 GNPNALASALENIVRNALRYSH--TKIEVAFSVDKDGLTITVDDDGPGVPEEEREQIFRPFYRVDEARDRESggtglGLA 426

                        250       260       270
                 ....*....|....*....|....*....|..
gi 489200333 409 IVQAIVQ--RCQCRLDfDSRADGLRVTLEMPL 438
Cdd:PRK09470 427 IVENAIQqhRGWVKAE-DSPLGGLRLTIWLPL 457
PRK10549 PRK10549
two-component system sensor histidine kinase BaeS;
345-438 3.52e-05

two-component system sensor histidine kinase BaeS;


Pssm-ID: 182539 [Multi-domain]  Cd Length: 466  Bit Score: 45.78  E-value: 3.52e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489200333 345 NLLDNALRHTAAGTRVELAVETEQGCARFHVRDHGPGIAEADLPHLTRRFWRHGKSGGSGL-----GLAIVQAIVQRCQC 419
Cdd:PRK10549 359 NLLENSLRYTDSGGSLHISAEQRDKTLRLTFADSAPGVSDEQLQKLFERFYRTEGSRNRASggsglGLAICLNIVEAHNG 438

                         90       100
                 ....*....|....*....|
gi 489200333 420 RLDFD-SRADGLRVTLEMPL 438
Cdd:PRK10549 439 RIIAAhSPFGGVSITVELPL 458
HATPase_VanS-like cd16923
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 342-396 3.01e-04

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Enterococcus faecium VanS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Enterococcus faecium VanS HK of the VanS-VanR two-component regulatory system (TCS) which activates the transcription of vanH, vanA and vanX vancomycin resistance genes. It also contains Ecoli YedV and PcoS, probable members of YedW-YedV TCS and PcoS-PcoR TCS, repectively. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); most also have a HAMP sensor domain.


Pssm-ID: 340400 [Multi-domain]  Cd Length: 102  Bit Score: 40.06  E-value: 3.01e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 489200333 342 ALRNLLDNALRHTAAGTRVELAVETEQGCARFHVRDHGPGIAEADLPHLTRRFWR 396
Cdd:cd16923    4 VFSNLLSNAIKYSPENTRIYITSFLTDDVVNIMFKNPSSHPLDFKLEKLFERFYR 58
RsbW COG2172
Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms];
300-388 3.11e-04

Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms];


Pssm-ID: 441775 [Multi-domain]  Cd Length: 127  Bit Score: 40.28  E-value: 3.11e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489200333 300 AEDAARVAMHDAGHGDERMFELRLAdgLSEAplevpsvlaiaalrnlLDNALRHT---AAGTRVELAVETEQGCARFHVR 376
Cdd:COG2172   14 ARRAVRALLRELGLDEDDADDLVLA--VSEA----------------VTNAVRHAyggDPDGPVEVELELDPDGLEIEVR 75

                         90
                 ....*....|..
gi 489200333 377 DHGPGIAEADLP 388
Cdd:COG2172   76 DEGPGFDPEDLP 87
HATPase_DpiB-CitA-like cd16915
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 340-417 6.15e-04

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 DpiB, DcuS, and Bacillus subtilis CitS, DctS, and YufL; This family includes histidine kinase-like ATPase domains of Escherichia coli K-12 DpiB and DcuS, and Bacillus subtilis CitS, DctS and MalK histidine kinases (HKs) all of which are two component transduction systems (TCSs). E. coli K-12 DpiB (also known as CitA) is the histidine kinase (HK) of DpiA-DpiB, a two-component signal transduction system (TCS) required for the expression of citrate-specific fermentation genes and genes involved in plasmid inheritance. E. coli K-12 DcuS (also known as YjdH) is the HK of DcuS-DcuR, a TCS that in the presence of the extracellular C4-dicarboxlates, activates the expression of the genes of anaerobic fumarate respiration and of aerobic C4-dicarboxylate uptake. CitS is the HK of Bacillus subtilis CitS-CitT, a TCS which regulates expression of CitM, the Mg-citrate transporter. Bacillus subtilis DctS forms a tripartite sensor unit (DctS/DctA/DctB) for sensing C4 dicarboxylates. Bacillus subtilis MalK (also known as YfuL) is the HK of MalK-MalR (YufL-YufM) a TCS which regulates the expression of the malate transporters MaeN (YufR) and YflS, and is essential for utilization of malate in minimal medium. Proteins having this DpiB-CitA-like HATPase domain generally have sensor domains such as Cache and PAS, and a histidine kinase A (HisKA)-like SpoOB-type, alpha-helical domain.


Pssm-ID: 340392 [Multi-domain]  Cd Length: 104  Bit Score: 39.19  E-value: 6.15e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489200333 340 IAALRNLLDNAL----RHTAAGTRVELAVETEQGCARFHVRDHGPGIAEADLPHLTRRFWRHGKSGGSGLGLAIVQAIVQ 415
Cdd:cd16915    2 ITIVGNLIDNALdalaATGAPNKQVEVFLRDEGDDLVIEVRDTGPGIAPELRDKVFERGVSTKGQGERGIGLALVRQSVE 81


                 ..
gi 489200333 416 RC 417
Cdd:cd16915   82 RL 83
HATPase_PhoQ-like cd16954
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 343-432 6.37e-04

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG. PhoQ is the histidine kinase (HK) of the PhoP-PhoQ two-component regulatory system (TCS), which responds to the levels of Mg2+ and Ca2+, controls virulence, mediates the adaptation to Mg2+-limiting environments, and regulates numerous cellular activities. Providencia stuartii AarG is a putative sensor kinase which controls the expression of the 2'-N-acetyltransferase and an intrinsic multiple antibiotic resistance (Mar) response in Providencia stuartii. The AarG product is similar to PhoQ in that it is able to restore wild-type levels of resistance to a Salmonella typhimurium phoQ mutant. However, the expression of the 2'-N-acetyltransferase gene and of aarP (a gene encoding a transcriptional activator of 2'-N-acetyltransferase) are not significantly affected by the levels of Mg2+ or Ca2+. Most proteins in this group contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have an accessory HAMP sensor domain, and some have an intracellular membrane -interaction PhoQ sensor domain.


Pssm-ID: 340430 [Multi-domain]  Cd Length: 135  Bit Score: 39.92  E-value: 6.37e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489200333 343 LRNLLDNALRHtaAGTRVELAVETEQGCARFHVRDHGPGIAEADLPHLTRRFWR-HGKSGGSGLGLAIVQAIVQRCQCRL 421
Cdd:cd16954   42 LGNLLDNACKW--CLEFVEVTARQTDGGLHLIVDDDGPGVPESQRSKIFQRGQRlDEQRPGQGLGLAIAKEIVEQYGGEL 119

                         90
                 ....*....|..
gi 489200333 422 DF-DSRADGLRV 432
Cdd:cd16954  120 SLsDSPLGGARF 131
ComP COG4585
Signal transduction histidine kinase ComP [Signal transduction mechanisms];
217-388 8.69e-04

Signal transduction histidine kinase ComP [Signal transduction mechanisms];


Pssm-ID: 443642 [Multi-domain]  Cd Length: 252  Bit Score: 40.76  E-value: 8.69e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489200333 217 QRIAQAIERERRltgDAAHELR----SPLTAIKTHLQVARMTEGAAAEQALAHAEEGADRLHRTLDQLLLLARVEGSLSF 292
Cdd:COG4585   44 ARAEEAREEERR---RIARELHdgvgQSLSAIKLQLEAARRLLDADPEAAREELEEIRELAREALAELRRLVRGLRPPAL 120

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489200333 293 DD-GVQCSAEDAARVAMHDAGhgdermFELRLAdgLSEAPLEVPSVLAIAALRNL---LDNALRHtAAGTRVELAVETEQ 368
Cdd:COG4585  121 DDlGLAAALEELAERLLRAAG------IRVELD--VDGDPDRLPPEVELALYRIVqeaLTNALKH-AGATRVTVTLEVDD 191

                        170       180
                 ....*....|....*....|
gi 489200333 369 GCARFHVRDHGPGIAEADLP 388
Cdd:COG4585  192 GELTLTVRDDGVGFDPEAAP 211
PRK15347 PRK15347
two component system sensor kinase;
333-440 1.36e-03

two component system sensor kinase;


Pssm-ID: 237951 [Multi-domain]  Cd Length: 921  Bit Score: 41.17  E-value: 1.36e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489200333 333 EVPSVLAIAALR------NLLDNALRHTAAGtRVELAVETEQGCARFHVRDHGPGIAEADLPHLTRRFWR-HGKSGGSGL 405
Cdd:PRK15347 502 HVPLYLHLDSLRlrqilvNLLGNAVKFTETG-GIRLRVKRHEQQLCFTVEDTGCGIDIQQQQQIFTPFYQaDTHSQGTGL 580

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 489200333 406 GLAIVQAIVQRCQCRLDFDSR-ADGLRVTLEMPLRE 440
Cdd:PRK15347 581 GLTIASSLAKMMGGELTLFSTpGVGSCFSLVLPLNE 616
PRK10364 PRK10364
two-component system sensor histidine kinase ZraS;
216-390 2.48e-03

two-component system sensor histidine kinase ZraS;


Pssm-ID: 236674 [Multi-domain]  Cd Length: 457  Bit Score: 40.15  E-value: 2.48e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489200333 216 FQRIAQAIERERR----------LTGDAAHELRSPLTAIKTHLQ--VARMTEGAAAEQALAHAEEGADRLHRTLDQLLLL 283
Cdd:PRK10364 217 YLRSRQLLQDEMKrkeklvalghLAAGVAHEIRNPLSSIKGLAKyfAERAPAGGEAHQLAQVMAKEADRLNRVVSELLEL 296

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489200333 284 ARvEGSLSFDDG-VQCSAEDAARVAMHDAgHGDERMFELRLADGLSEAPLEVPSVLAIaaLRNLLDNALRHTAAGTRVEL 362
Cdd:PRK10364 297 VK-PTHLALQAVdLNDLINHSLQLVSQDA-NSREIQLRFTANDTLPEIQADPDRLTQV--LLNLYLNAIQAIGQHGVISV 372

                        170       180
                 ....*....|....*....|....*...
gi 489200333 363 AVETEQGCARFHVRDHGPGIAEADLPHL 390
Cdd:PRK10364 373 TASESGAGVKISVTDSGKGIAADQLEAI 400
YesM COG2972
Sensor histidine kinase YesM [Signal transduction mechanisms];
177-440 2.78e-03

Sensor histidine kinase YesM [Signal transduction mechanisms];


Pssm-ID: 442211 [Multi-domain]  Cd Length: 445  Bit Score: 40.00  E-value: 2.78e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489200333 177 PLKRIRDALTRRGADSLEPLELAAlPSELKPLVETQNQLFQRIAQAIERERRLTGDAAH-ELRSpLTA-IKTH-----LQ 249
Cdd:COG2972  184 PIKRLKKAMKKVEKGDLVRLEVSG-NDEIGILARSFNEMVERIKELIEEVYELELEKKEaELKA-LQAqINPHflfntLN 261

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489200333 250 VARMTegaaaeqalaHAEEGADRLHRTLDQLLLLARVegSLSFDDGVQCSAE--DAAR--VAMHDAGHGDERMFELRLAD 325
Cdd:COG2972  262 SIRWL----------AELEDPEEAEEMLEALSKLLRY--SLSKGDELVTLEEelELIKsyLEIQKLRFGDRLEVEIEIDE 329

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489200333 326 GLSEAPleVPSVLaiaaLRNLLDNALRH----TAAGTRVELAVETEQGCARFHVRDHGPGIAEADLPHLTRRFWRHgksg 401
Cdd:COG2972  330 ELLDLL--IPKLI----LQPLVENAIEHgiepKEGGGTIRISIRKEGDRLVITVEDNGVGMPEEKLEKLLEELSSK---- 399

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*
gi 489200333 402 GSGLGLAI--VQAIVQRC---QCRLDFDSRAD-GLRVTLEMPLRE 440
Cdd:COG2972  400 GEGRGIGLrnVRERLKLYygeEYGLEIESEPGeGTTVTIRIPLEE 444
HATPase_EvgS-ArcB-TorS-like cd16922
Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid ...
 343-438 5.74e-03

Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid sensor histidine kinases, similar to Escherichia coli EvgS, ArcB, TorS, BarA, RcsC; This family contains the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinases (HKs), including the following Escherichia coli HKs: EvgS, a HK of the EvgS-EvgA two-component system (TCS) that confers acid resistance; ArcB, a HK of the ArcB-ArcA TCS that modulates the expression of numerous genes in response to respiratory growth conditions; TorS, a HK of the TorS-TorR TCS which is involved in the anaerobic utilization of trimethylamine-N-oxide; BarA, a HK of the BarA-UvrY TCS involved in the regulation of carbon metabolism; and RcsC, a HK of the RcsB-RcsC TCS which regulates the expression of the capsule operon and of the cell division gene ftsZ. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), with most having accessory sensor domain(s) such as GAF, PAS and CHASE; many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.


Pssm-ID: 340399 [Multi-domain]  Cd Length: 110  Bit Score: 36.32  E-value: 5.74e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489200333 343 LRNLLDNALRHTAAGT---RVELAVETEQGCA-RFHVRDHGPGIAEADLPHL-----------TRRFwrhgksGGSGLGL 407
Cdd:cd16922    5 LLNLLGNAIKFTEEGEvtlRVSLEEEEEDGVQlRFSVEDTGIGIPEEQQARLfepfsqadsstTRKY------GGTGLGL 78

                         90       100       110
                 ....*....|....*....|....*....|..
gi 489200333 408 AIVQAIVQRCQCRLDFDSR-ADGLRVTLEMPL 438
Cdd:cd16922   79 AISKKLVELMGGDISVESEpGQGSTFTFTLPL 110
HATPase_MutL-MLH-PMS-like cd16926
Histidine kinase-like ATPase domain of DNA mismatch repair proteins Escherichia coli MutL, ...
 341-394 5.85e-03

Histidine kinase-like ATPase domain of DNA mismatch repair proteins Escherichia coli MutL, human MutL homologs (MLH/ PMS), and related domains; This family includes the histidine kinase-like ATPase (HATPase) domains of Escherichia coli MutL, human MLH1 (mutL homolog 1), human PMS1 (PMS1 homolog 1, mismatch repair system component), human MLH3 (mutL homolog 3), and human PMS2 (PMS1 homolog 2, mismatch repair system component). MutL homologs (MLH/PMS) participate in MMR (DNA mismatch repair), and in addition have role(s) in DNA damage signaling and suppression of homologous recombination (recombination between partially homologous parental DNAs). The primary role of MutL in MMR is to mediate protein-protein interactions during mismatch recognition and strand removal; a ternary complex is formed between MutS, MutL, and the mismatched DNA, which activates the MutH endonuclease.


Pssm-ID: 340403 [Multi-domain]  Cd Length: 188  Bit Score: 37.80  E-value: 5.85e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....
gi 489200333 341 AALRNLLDNALrhTAAGTRVELAVEtEQGCARFHVRDHGPGIAEADLPHLTRRF 394
Cdd:cd16926   16 SVVKELVENSI--DAGATRIDVEIE-EGGLKLIRVTDNGSGISREDLELAFERH 66
HATPase_BceS-YxdK-YvcQ-like cd16948
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 342-388 9.52e-03

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis BceS, YxdK, and Bacillus thuringiensis YvcQ; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis BceS and Bacillus thuringiensis YvcQ, the HKs of the two-component regulatory system (TCSs) BceS-BceR and YvcQ-YvcP, repsectively, which are both involved in regulating bacitracin resistance. It also includes the HATPase domain of YxdK, the HK of YxdK-YxdJ TCS involved in sensing antimicrobial compounds.


Pssm-ID: 340424 [Multi-domain]  Cd Length: 109  Bit Score: 35.72  E-value: 9.52e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*..
gi 489200333 342 ALRNLLDNALRHTAAGTRVELAVETEQGCARFHVRDHGPGIAEADLP 388
Cdd:cd16948    9 IIGQIVSNALKYSKQGGKIEIYSETNEQGVVLSIKDFGIGIPEEDLP 55
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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