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Conserved domains on  [gi|489197409|ref|WP_003106707|]
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MULTISPECIES: (d)CMP kinase [Pseudomonas]

Protein Classification

(d)CMP kinase( domain architecture ID 10785233)

(d)CMP kinase catalyzes the phosphorylation of cytidine monophosphate (CMP) or dCMP to produce cytidine diphosphate (CDP) or dCDP, using ATP as the preferred phosphoryl donor

CATH:  3.40.50.300
Gene Ontology:  GO:0036431|GO:0006220|GO:0005524
PubMed:  10218107

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Cmk COG0283
Cytidylate kinase [Nucleotide transport and metabolism];
6-224 4.08e-128

Cytidylate kinase [Nucleotide transport and metabolism];


:

Pssm-ID: 440052 [Multi-domain]  Cd Length: 220  Bit Score: 360.49  E-value: 4.08e-128
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489197409   6 PMLAIDGPSGAGKGTVAGLLARRLGWNLLDSGALYRLLAFAAVNHGVDLTNEEALKVLAAHLDVQFVAADGshGQRIILE 85
Cdd:COG0283    1 PVIAIDGPAGSGKSTVAKALAKRLGYHYLDTGAMYRAVALAALRNGIDLDDEEALAALARNLDIEFETDPG--GQRVFLN 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489197409  86 GEEVTDVIRTEQVGAGASQVAALPAVRDALLQRQRAFREAPGLVADGRDMGTVVFPDAPLKIFLTASAEERARRRYLQLK 165
Cdd:COG0283   79 GEDVTDEIRTEEVSNAVSKVAAIPEVREALVALQRAFAKAPGLVADGRDIGTVVFPDAELKIFLTASAEERARRRYKELK 158

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 489197409 166 AKGADVDQSALLEEIRERDERDSQRAVAPLKPADDAILLDSTEMSIEAVVETIIRHCER 224
Cdd:COG0283  159 EKGISVSLEELLADIKERDERDSTRAVAPLKPAEDAIVIDTTDLSIEEVVEKILALVRE 217
 
Name Accession Description Interval E-value
Cmk COG0283
Cytidylate kinase [Nucleotide transport and metabolism];
6-224 4.08e-128

Cytidylate kinase [Nucleotide transport and metabolism];


Pssm-ID: 440052 [Multi-domain]  Cd Length: 220  Bit Score: 360.49  E-value: 4.08e-128
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489197409   6 PMLAIDGPSGAGKGTVAGLLARRLGWNLLDSGALYRLLAFAAVNHGVDLTNEEALKVLAAHLDVQFVAADGshGQRIILE 85
Cdd:COG0283    1 PVIAIDGPAGSGKSTVAKALAKRLGYHYLDTGAMYRAVALAALRNGIDLDDEEALAALARNLDIEFETDPG--GQRVFLN 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489197409  86 GEEVTDVIRTEQVGAGASQVAALPAVRDALLQRQRAFREAPGLVADGRDMGTVVFPDAPLKIFLTASAEERARRRYLQLK 165
Cdd:COG0283   79 GEDVTDEIRTEEVSNAVSKVAAIPEVREALVALQRAFAKAPGLVADGRDIGTVVFPDAELKIFLTASAEERARRRYKELK 158

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 489197409 166 AKGADVDQSALLEEIRERDERDSQRAVAPLKPADDAILLDSTEMSIEAVVETIIRHCER 224
Cdd:COG0283  159 EKGISVSLEELLADIKERDERDSTRAVAPLKPAEDAIVIDTTDLSIEEVVEKILALVRE 217
PRK11860 PRK11860
bifunctional 3-phosphoshikimate 1-carboxyvinyltransferase/cytidylate kinase;
4-219 5.35e-100

bifunctional 3-phosphoshikimate 1-carboxyvinyltransferase/cytidylate kinase;


Pssm-ID: 237003 [Multi-domain]  Cd Length: 661  Bit Score: 303.89  E-value: 5.35e-100
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489197409   4 AVPMLAIDGPSGAGKGTVAGLLARRLGWNLLDSGALYRLLAFAAVNHGVDLTNEEALKVLAAHLDVQFvaadgsHGQRII 83
Cdd:PRK11860 441 RVPVICIDGPTASGKGTVAARVAEALGYHYLDSGALYRLTALAALRAGVALDDEAAIAALARGLPVRF------EGDRIW 514

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489197409  84 LEGEEVTDVIRTEQVGAGASQVAALPAVRDALLQRQRAFREAPGLVADGRDMGTVVFPDAPLKIFLTASAEERARRRYLQ 163
Cdd:PRK11860 515 LGGEDVTDAIRTEAAGMGASRVSALPAVRAALLALQRSFRRLPGLVADGRDMGTVIFPDAALKVFLTASAEARAERRYKQ 594

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 489197409 164 LKAKGADVDQSALLEEIRERDERDSQRAVAPLKPADDAILLDSTEMSIEAVVETII 219
Cdd:PRK11860 595 LISKGISANIADLLADLEARDARDTQRSVAPLKPAQDALLLDNSDLTIEQAVAQVL 650
Cytidylate_kin pfam02224
Cytidylate kinase; Cytidylate kinase EC:2.7.4.14 catalyzes the phosphorylation of cytidine 5 ...
 9-220 3.41e-94

Cytidylate kinase; Cytidylate kinase EC:2.7.4.14 catalyzes the phosphorylation of cytidine 5'-monophosphate (dCMP) to cytidine 5'-diphosphate (dCDP) in the presence of ATP or GTP.


Pssm-ID: 280401 [Multi-domain]  Cd Length: 211  Bit Score: 274.57  E-value: 3.41e-94
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489197409    9 AIDGPSGAGKGTVAGLLARRLGWNLLDSGALYRLLAFAAVNHGVDLTNEEALKVLAAHLDVQFVAadgshgQRIILEGEE 88
Cdd:pfam02224   2 AIDGPSGSGKSTVARILARKLGYKYLDTGAMYRALALAALRQKVDLTDEDALAELASEVDISFGH------TEVFLNGED 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489197409   89 VTDVIRTEQVGAGASQVAALPAVRDALLQRQRAFREAPGLVADGRDMGTVVFPDAPLKIFLTASAEERARRRYLQLKAKG 168
Cdd:pfam02224  76 VSSEIRTDEVAQAASQVAAIPAVRARLNKLQRQLAKNGNIVMEGRDIGTVVFPDAEVKIFLTASPEERAKRRYKQLQAKG 155

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|..
gi 489197409  169 ADVDQSALLEEIRERDERDSQRAVAPLKPADDAILLDSTEMSIEAVVETIIR 220
Cdd:pfam02224 156 LSVDFEELLAEIKRRDKRDSERAVGPLKPAPDALIIDTSKLTIEEVVEKILE 207
cmk TIGR00017
cytidylate kinase; This family consists of cytidylate kinase, which catalyzes the ...
 6-219 2.36e-93

cytidylate kinase; This family consists of cytidylate kinase, which catalyzes the phosphorylation of cytidine 5-monophosphate (dCMP) to cytidine 5 -diphosphate (dCDP) in the presence of ATP or GTP. UMP and dCMP can also act as acceptors. [Purines, pyrimidines, nucleosides, and nucleotides, Nucleotide and nucleoside interconversions]


Pssm-ID: 129128 [Multi-domain]  Cd Length: 217  Bit Score: 272.76  E-value: 2.36e-93
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489197409    6 PMLAIDGPSGAGKGTVAGLLARRLGWNLLDSGALYRLLAFAAVNHGVDLTNEEALKVLAAHLDVQFVAADGshGQRIILE 85
Cdd:TIGR00017   3 MIIAIDGPSGAGKSTVAKAVAEKLGYAYLDSGAMYRAIALAALQNRVDLTSEDALAELISHLDIRFIPTNG--EVEVFLN 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489197409   86 GEEVTDVIRTEQVGAGASQVAALPAVRDALLQRQRAFREAPGLVADGRDMGTVVFPDAPLKIFLTASAEERARRRYLQLK 165
Cdd:TIGR00017  81 GEDVSEAIRTQEVANAASKVAVFPKVREALLKRQQALAKNDGIIADGRDIGTVVFPNAEVKIFLDASVEERAKRRYKQLQ 160

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....
gi 489197409  166 AKGADVDQSALLEEIRERDERDSQRAVAPLKPADDAILLDSTEMSIEAVVETII 219
Cdd:TIGR00017 161 IKGNEVNFEELLAEIKERDDRDSNREVAPLKKADDALYLDTSNLSIDEVVEKIL 214
CMPK cd02020
Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine ...
 9-207 1.07e-70

Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor.


Pssm-ID: 238978 [Multi-domain]  Cd Length: 147  Bit Score: 212.35  E-value: 1.07e-70
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489197409   9 AIDGPSGAGKGTVAGLLARRLGWNLLDSGAlyrllafaavnhgvdltneealkvlaahldvqfvaadgshgqriilegee 88
Cdd:cd02020    3 AIDGPAGSGKSTVAKLLAKKLGLPYLDTGG-------------------------------------------------- 32

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489197409  89 vtdvIRTEQVGAGASQVAALPAVRDALLQRQRAFREAPGLVADGRDMGTVVFPDAPLKIFLTASAEERARRRYLQLKAKG 168
Cdd:cd02020   33 ----IRTEEVGKLASEVAAIPEVRKALDERQRELAKKPGIVLEGRDIGTVVFPDADLKIFLTASPEVRAKRRAKQLQAKG 108

                        170       180       190
                 ....*....|....*....|....*....|....*....
gi 489197409 169 ADVDQSALLEEIRERDERDSQRAVAPLKPADDAILLDST 207
Cdd:cd02020  109 EGVDLEEILAEIIERDERDSTRYVAPLKLAEDAIVIDTS 147
 
Name Accession Description Interval E-value
Cmk COG0283
Cytidylate kinase [Nucleotide transport and metabolism];
6-224 4.08e-128

Cytidylate kinase [Nucleotide transport and metabolism];


Pssm-ID: 440052 [Multi-domain]  Cd Length: 220  Bit Score: 360.49  E-value: 4.08e-128
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489197409   6 PMLAIDGPSGAGKGTVAGLLARRLGWNLLDSGALYRLLAFAAVNHGVDLTNEEALKVLAAHLDVQFVAADGshGQRIILE 85
Cdd:COG0283    1 PVIAIDGPAGSGKSTVAKALAKRLGYHYLDTGAMYRAVALAALRNGIDLDDEEALAALARNLDIEFETDPG--GQRVFLN 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489197409  86 GEEVTDVIRTEQVGAGASQVAALPAVRDALLQRQRAFREAPGLVADGRDMGTVVFPDAPLKIFLTASAEERARRRYLQLK 165
Cdd:COG0283   79 GEDVTDEIRTEEVSNAVSKVAAIPEVREALVALQRAFAKAPGLVADGRDIGTVVFPDAELKIFLTASAEERARRRYKELK 158

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 489197409 166 AKGADVDQSALLEEIRERDERDSQRAVAPLKPADDAILLDSTEMSIEAVVETIIRHCER 224
Cdd:COG0283  159 EKGISVSLEELLADIKERDERDSTRAVAPLKPAEDAIVIDTTDLSIEEVVEKILALVRE 217
PRK11860 PRK11860
bifunctional 3-phosphoshikimate 1-carboxyvinyltransferase/cytidylate kinase;
4-219 5.35e-100

bifunctional 3-phosphoshikimate 1-carboxyvinyltransferase/cytidylate kinase;


Pssm-ID: 237003 [Multi-domain]  Cd Length: 661  Bit Score: 303.89  E-value: 5.35e-100
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489197409   4 AVPMLAIDGPSGAGKGTVAGLLARRLGWNLLDSGALYRLLAFAAVNHGVDLTNEEALKVLAAHLDVQFvaadgsHGQRII 83
Cdd:PRK11860 441 RVPVICIDGPTASGKGTVAARVAEALGYHYLDSGALYRLTALAALRAGVALDDEAAIAALARGLPVRF------EGDRIW 514

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489197409  84 LEGEEVTDVIRTEQVGAGASQVAALPAVRDALLQRQRAFREAPGLVADGRDMGTVVFPDAPLKIFLTASAEERARRRYLQ 163
Cdd:PRK11860 515 LGGEDVTDAIRTEAAGMGASRVSALPAVRAALLALQRSFRRLPGLVADGRDMGTVIFPDAALKVFLTASAEARAERRYKQ 594

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 489197409 164 LKAKGADVDQSALLEEIRERDERDSQRAVAPLKPADDAILLDSTEMSIEAVVETII 219
Cdd:PRK11860 595 LISKGISANIADLLADLEARDARDTQRSVAPLKPAQDALLLDNSDLTIEQAVAQVL 650
Cytidylate_kin pfam02224
Cytidylate kinase; Cytidylate kinase EC:2.7.4.14 catalyzes the phosphorylation of cytidine 5 ...
 9-220 3.41e-94

Cytidylate kinase; Cytidylate kinase EC:2.7.4.14 catalyzes the phosphorylation of cytidine 5'-monophosphate (dCMP) to cytidine 5'-diphosphate (dCDP) in the presence of ATP or GTP.


Pssm-ID: 280401 [Multi-domain]  Cd Length: 211  Bit Score: 274.57  E-value: 3.41e-94
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489197409    9 AIDGPSGAGKGTVAGLLARRLGWNLLDSGALYRLLAFAAVNHGVDLTNEEALKVLAAHLDVQFVAadgshgQRIILEGEE 88
Cdd:pfam02224   2 AIDGPSGSGKSTVARILARKLGYKYLDTGAMYRALALAALRQKVDLTDEDALAELASEVDISFGH------TEVFLNGED 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489197409   89 VTDVIRTEQVGAGASQVAALPAVRDALLQRQRAFREAPGLVADGRDMGTVVFPDAPLKIFLTASAEERARRRYLQLKAKG 168
Cdd:pfam02224  76 VSSEIRTDEVAQAASQVAAIPAVRARLNKLQRQLAKNGNIVMEGRDIGTVVFPDAEVKIFLTASPEERAKRRYKQLQAKG 155

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|..
gi 489197409  169 ADVDQSALLEEIRERDERDSQRAVAPLKPADDAILLDSTEMSIEAVVETIIR 220
Cdd:pfam02224 156 LSVDFEELLAEIKRRDKRDSERAVGPLKPAPDALIIDTSKLTIEEVVEKILE 207
cmk TIGR00017
cytidylate kinase; This family consists of cytidylate kinase, which catalyzes the ...
 6-219 2.36e-93

cytidylate kinase; This family consists of cytidylate kinase, which catalyzes the phosphorylation of cytidine 5-monophosphate (dCMP) to cytidine 5 -diphosphate (dCDP) in the presence of ATP or GTP. UMP and dCMP can also act as acceptors. [Purines, pyrimidines, nucleosides, and nucleotides, Nucleotide and nucleoside interconversions]


Pssm-ID: 129128 [Multi-domain]  Cd Length: 217  Bit Score: 272.76  E-value: 2.36e-93
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489197409    6 PMLAIDGPSGAGKGTVAGLLARRLGWNLLDSGALYRLLAFAAVNHGVDLTNEEALKVLAAHLDVQFVAADGshGQRIILE 85
Cdd:TIGR00017   3 MIIAIDGPSGAGKSTVAKAVAEKLGYAYLDSGAMYRAIALAALQNRVDLTSEDALAELISHLDIRFIPTNG--EVEVFLN 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489197409   86 GEEVTDVIRTEQVGAGASQVAALPAVRDALLQRQRAFREAPGLVADGRDMGTVVFPDAPLKIFLTASAEERARRRYLQLK 165
Cdd:TIGR00017  81 GEDVSEAIRTQEVANAASKVAVFPKVREALLKRQQALAKNDGIIADGRDIGTVVFPNAEVKIFLDASVEERAKRRYKQLQ 160

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....
gi 489197409  166 AKGADVDQSALLEEIRERDERDSQRAVAPLKPADDAILLDSTEMSIEAVVETII 219
Cdd:TIGR00017 161 IKGNEVNFEELLAEIKERDDRDSNREVAPLKKADDALYLDTSNLSIDEVVEKIL 214
PRK13477 PRK13477
bifunctional pantoate--beta-alanine ligase/(d)CMP kinase;
6-220 6.99e-85

bifunctional pantoate--beta-alanine ligase/(d)CMP kinase;


Pssm-ID: 237393 [Multi-domain]  Cd Length: 512  Bit Score: 260.97  E-value: 6.99e-85
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489197409   6 PMLAIDGPSGAGKGTVAGLLARRLGWNLLDSGALYRLLAFAAVNHGVDLTNEEALKVLAAHLDVQFVAADGSHgQRIILE 85
Cdd:PRK13477 285 PIIAIDGPAGAGKSTVTRAVAKKLGLLYLDTGAMYRAVTWLVLQEGIDPQDEEALAELLSDLKIELKPSSGSP-QRVWIN 363

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489197409  86 GEEVTDVIRTEQVGAGASQVAALPAVRDALLQRQRAFREAPGLVADGRDMGTVVFPDAPLKIFLTASAEERARRRYLQLK 165
Cdd:PRK13477 364 GEDVTEAIRSPEVTSSVSAIAAQPAVRQALVKQQQRIGEKGGLVAEGRDIGTHVFPDAELKIFLTASVEERARRRALDLQ 443

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 489197409 166 AKG-ADVDQSALLEEIRERDERDSQRAVAPLKPADDAILLDSTEMSIEAVVETIIR 220
Cdd:PRK13477 444 AQGfPVIDLEQLEAQIAERDRLDSTREIAPLRKADDAIELITDGLSIEEVVDKIID 499
CMPK cd02020
Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine ...
 9-207 1.07e-70

Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor.


Pssm-ID: 238978 [Multi-domain]  Cd Length: 147  Bit Score: 212.35  E-value: 1.07e-70
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489197409   9 AIDGPSGAGKGTVAGLLARRLGWNLLDSGAlyrllafaavnhgvdltneealkvlaahldvqfvaadgshgqriilegee 88
Cdd:cd02020    3 AIDGPAGSGKSTVAKLLAKKLGLPYLDTGG-------------------------------------------------- 32

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489197409  89 vtdvIRTEQVGAGASQVAALPAVRDALLQRQRAFREAPGLVADGRDMGTVVFPDAPLKIFLTASAEERARRRYLQLKAKG 168
Cdd:cd02020   33 ----IRTEEVGKLASEVAAIPEVRKALDERQRELAKKPGIVLEGRDIGTVVFPDADLKIFLTASPEVRAKRRAKQLQAKG 108

                        170       180       190
                 ....*....|....*....|....*....|....*....
gi 489197409 169 ADVDQSALLEEIRERDERDSQRAVAPLKPADDAILLDST 207
Cdd:cd02020  109 EGVDLEEILAEIIERDERDSTRYVAPLKLAEDAIVIDTS 147
PRK09518 PRK09518
bifunctional cytidylate kinase/GTPase Der; Reviewed
 8-220 6.71e-47

bifunctional cytidylate kinase/GTPase Der; Reviewed


Pssm-ID: 236546 [Multi-domain]  Cd Length: 712  Bit Score: 164.58  E-value: 6.71e-47
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489197409   8 LAIDGPSGAGKGTVAGLLARRLGWNLLDSGALYRLLAFAAVNHGVDLTNEEALK------VLAAHLDVQFVAADGSHGQR 81
Cdd:PRK09518   4 VAIDGPAGVGKSSVSRALAQYLGYAYLDTGAMYRACAWWCLKQGIDLDAELVDEqvvteaVGEFFTGLHFDISVDPDSPG 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489197409  82 IILEGEEVTDVIRTEQVGAGASQVAALPAVRDALLQRQRA----------FREAPGLVADGRDMGTVVFPDAPLKIFLTA 151
Cdd:PRK09518  84 VFADGEDISEEIRSPEVSSHVSAVAAIPPVRNVLIAAQRAyiareasadsFSGGLGIVAEGRDITTVVAPDAEVRILLTA 163

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 489197409 152 SAEERARRRYLQLKAKGADVdqsaLLEEIRERDERDSqRAVAPLKPADDAILLDSTEMSIEAVVETIIR 220
Cdd:PRK09518 164 REEVRQARRSGQDRSETPGV----VLEDVAARDEADS-KVTSFLSAADGVTTLDNSDLDFDETLDLLIG 227
PRK12269 PRK12269
bifunctional cytidylate kinase/ribosomal protein S1; Provisional
 7-226 5.88e-29

bifunctional cytidylate kinase/ribosomal protein S1; Provisional


Pssm-ID: 105491 [Multi-domain]  Cd Length: 863  Bit Score: 114.04  E-value: 5.88e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489197409   7 MLAIDGPSGAGKGTVAGLLARRLGWNLLDSGALYRLLAFAAVNHGVDLTNEE-------------ALKVLAAHLDVQFVA 73
Cdd:PRK12269  36 IIALDGPAGSGKSSVCRLLASRLGAQCLNTGSFYRAFTLAALRRVSELAVQAcspspdpdaavgcAAVPHATNLDTSYAP 115

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489197409  74 ADG---------------------SHGQRIILEGEE-VTDVIRTEQVGAGASQVAALPAVRDALLQRQRAFREAPGLVAD 131
Cdd:PRK12269 116 LTAqkkvalfdeaywvsfartvalSYRAGVMYVGEEnVESLLRSDEVESAVSYFAAMPAIRAIMTGKIRSAVCGARVVCE 195

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489197409 132 GRDMGTVVFPDAPLKIFLTASAEERARRRYLQLKAKgadVDQSALLEEIRERDERDSQRAVAPLKPADDAILLDSTEMSI 211
Cdd:PRK12269 196 GRDLTTVVFVDADLKCYLDASIEARVARRWAQGTSR---LSKQELEQRMRARDAHDRARTVGGLRCAPDALYVDTSCLTI 272

                        250
                 ....*....|....*
gi 489197409 212 EAVVETIIRHCERQG 226
Cdd:PRK12269 273 EEVCERIAREAHRRA 287
CmkB COG1102
Cytidylate kinase [Nucleotide transport and metabolism];
9-220 2.23e-10

Cytidylate kinase [Nucleotide transport and metabolism];


Pssm-ID: 440719 [Multi-domain]  Cd Length: 188  Bit Score: 57.91  E-value: 2.23e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489197409   9 AIDGPSGAGKGTVAGLLARRLGWNLLDSgalyRLLAFAAVNHGVDLtnEEALKVLaahldvqfvaadgshgqriilegee 88
Cdd:COG1102    4 TISREPGSGGTTIAKRLAEKLGLPLYDG----EILREAAKERGLSE--EEFEKLD------------------------- 52

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489197409  89 vtdvirtEQVGAGASQVAALP-AVRDALLQRQRAFREAPGLVADGRdMGTVVFPDAP--LKIFLTASAEERARR---RYl 162
Cdd:COG1102   53 -------EKAPSLLYRDTAEEdEIDRALDKVIRELARKGNCVIVGR-LADWILRDRPnvLKVFLTAPLEVRVKRiaeRE- 123

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 489197409 163 qlkakgaDVDQSALLEEIRERDERDSQR--AVAPLKPADDAI---LLDSTEMSIEAVVETIIR 220
Cdd:COG1102  124 -------GISEEEAEKEIKKRDKSRAKYykYYYGIDWGDPSNydlVINTSRLGIEEAVDLILA 179
PRK04182 PRK04182
cytidylate kinase; Provisional
 8-220 5.67e-09

cytidylate kinase; Provisional


Pssm-ID: 235244 [Multi-domain]  Cd Length: 180  Bit Score: 53.66  E-value: 5.67e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489197409   8 LAIDGPSGAGKGTVAGLLARRLGWNLLDSGALYRLLAfaaVNHGVDLtnEEALKVlaahldvqfvaadgshgqriileGE 87
Cdd:PRK04182   3 ITISGPPGSGKTTVARLLAEKLGLKHVSAGEIFRELA---KERGMSL--EEFNKY-----------------------AE 54

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489197409  88 EVTDVIRteqvgagasqvaalpavrdALLQRQRAF-REAPGLVADGRDMGTVVFPDAPLKIFLTASAEERARRrylQLKA 166
Cdd:PRK04182  55 EDPEIDK-------------------EIDRRQLEIaEKEDNVVLEGRLAGWMAKDYADLKIWLKAPLEVRAER---IAER 112

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 489197409 167 KGADVDQSalLEEIRERDERDSQRA-------VAPLKPADdaILLDSTEMSIEAVVETIIR 220
Cdd:PRK04182 113 EGISVEEA--LEETIEREESEAKRYkeyygidIDDLSIYD--LVINTSRWDPEGVFDIILT 169
AroK COG0703
Shikimate kinase [Amino acid transport and metabolism]; Shikimate kinase is part of the ...
 12-224 3.42e-04

Shikimate kinase [Amino acid transport and metabolism]; Shikimate kinase is part of the Pathway/BioSystem: Aromatic amino acid biosynthesis


Pssm-ID: 440467 [Multi-domain]  Cd Length: 165  Bit Score: 39.73  E-value: 3.42e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489197409  12 GPSGAGKGTVAGLLARRLGWNLLDsgalyrllafaavnhgvdltneealkvlaahLDVQFVAADGSHGQRII-LEGEEV- 89
Cdd:COG0703    5 GMMGAGKSTVGRLLAKRLGLPFVD-------------------------------TDAEIEERAGMSIPEIFaEEGEAGf 53

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489197409  90 ----TDVIRteQVGAGASQVAAL-------PAVRDALLQRqrafreapglvadgrdmGTVVfpdaplkiFLTASAEERAR 158
Cdd:COG0703   54 releREVLA--ELLEEENAVIATgggavlsPENRELLKEH-----------------GTVV--------YLDASPETLLE 106

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 489197409 159 RryLQLKAKGADVDQSALLEEIRER-DERDsqravaPL--KPADdaILLDSTEMSIEAVVETIIRHCER 224
Cdd:COG0703  107 R--LRRDDNRPLLQGEDPRERLEELlAERE------PLyrEVAD--ITVDTDGRSPEEVVDEILEALEE 165
GntK cd02021
Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting ...
 12-118 4.49e-04

Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits.


Pssm-ID: 238979 [Multi-domain]  Cd Length: 150  Bit Score: 39.16  E-value: 4.49e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489197409  12 GPSGAGKGTVAGLLARRLGWNLLDSGALYRLLAFAAVNHGVDLTNEEALKVLAAHLDvQFVAADGSHGQRIILE----GE 87
Cdd:cd02021    6 GVSGSGKSTVGKALAERLGAPFIDGDDLHPPANIAKMAAGIPLNDEDRWPWLQALTD-ALLAKLASAGEGVVVAcsalKR 84

                         90       100       110
                 ....*....|....*....|....*....|.
gi 489197409  88 EVTDVIRTEQVGAGAsQVAALPAVRDALLQR 118
Cdd:cd02021   85 IYRDILRGGAANPRV-RFVHLDGPREVLAER 114
Udk COG0572
Uridine kinase [Nucleotide transport and metabolism]; Uridine kinase is part of the Pathway ...
 1-30 5.42e-04

Uridine kinase [Nucleotide transport and metabolism]; Uridine kinase is part of the Pathway/BioSystem: Pyrimidine salvage


Pssm-ID: 440337 [Multi-domain]  Cd Length: 206  Bit Score: 39.82  E-value: 5.42e-04
                         10        20        30
                 ....*....|....*....|....*....|
gi 489197409   1 MNGAVPMLAIDGPSGAGKGTVAGLLARRLG 30
Cdd:COG0572    3 RSGKPRIIGIAGPSGSGKTTFARRLAEQLG 32
PRK06547 PRK06547
hypothetical protein; Provisional
 10-40 6.68e-04

hypothetical protein; Provisional


Pssm-ID: 235825  Cd Length: 172  Bit Score: 39.34  E-value: 6.68e-04
                         10        20        30
                 ....*....|....*....|....*....|.
gi 489197409  10 IDGPSGAGKGTVAGLLARRLGWNLLDSGALY 40
Cdd:PRK06547  20 IDGRSGSGKTTLAGALAARTGFQLVHLDDLY 50
ADK cd01428
Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine ...
 12-86 1.67e-03

Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for homeostasis of adenosine phosphates.


Pssm-ID: 238713 [Multi-domain]  Cd Length: 194  Bit Score: 38.37  E-value: 1.67e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489197409  12 GPSGAGKGTVAGLLARRLGWNLLDSGALYR----------LLAFAAVNHGVDLTNEEALKVLAAHLDvqfvAADGSHGqr 81
Cdd:cd01428    6 GPPGSGKGTQAERLAKKYGLPHISTGDLLReeiasgtelgKKAKEYIDSGKLVPDEIVIKLLKERLK----KPDCKKG-- 79


                 ....*
gi 489197409  82 IILEG 86
Cdd:cd01428   80 FILDG 84
ADK pfam00406
Adenylate kinase;
12-41 1.85e-03

Adenylate kinase;


Pssm-ID: 395329 [Multi-domain]  Cd Length: 184  Bit Score: 38.06  E-value: 1.85e-03
                          10        20        30
                  ....*....|....*....|....*....|
gi 489197409   12 GPSGAGKGTVAGLLARRLGWNLLDSGALYR 41
Cdd:pfam00406   3 GPPGAGKGTQAEKIVQKYGLPHLSTGDLLR 32
aroK PRK00131
shikimate kinase; Reviewed
 12-36 2.21e-03

shikimate kinase; Reviewed


Pssm-ID: 234654 [Multi-domain]  Cd Length: 175  Bit Score: 37.48  E-value: 2.21e-03
                         10        20
                 ....*....|....*....|....*
gi 489197409  12 GPSGAGKGTVAGLLARRLGWNLLDS 36
Cdd:PRK00131  11 GFMGAGKSTIGRLLAKRLGYDFIDT 35
Pgk2 COG2074
2-phosphoglycerate kinase/Mevalonate-3-phosphate 5-kinase [Carbohydrate transport and ...
 10-37 4.44e-03

2-phosphoglycerate kinase/Mevalonate-3-phosphate 5-kinase [Carbohydrate transport and metabolism, Lipid transport and metabolism];


Pssm-ID: 441677  Cd Length: 207  Bit Score: 36.85  E-value: 4.44e-03
                         10        20
                 ....*....|....*....|....*...
gi 489197409  10 IDGPSGAGKGTVAGLLARRLGWNLLDSG 37
Cdd:COG2074   11 IGGASGVGKSTIAAELARRLGIPRVIST 38
SK cd00464
Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic ...
 12-36 4.67e-03

Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis of aromatic compounds, such as aromatic amino acids, p-aminobenzoic acid, folate and ubiquinone. Shikimate kinase catalyses the phosphorylation of the 3-hydroxyl group of shikimic acid using ATP.


Pssm-ID: 238260 [Multi-domain]  Cd Length: 154  Bit Score: 36.38  E-value: 4.67e-03
                         10        20
                 ....*....|....*....|....*
gi 489197409  12 GPSGAGKGTVAGLLARRLGWNLLDS 36
Cdd:cd00464    6 GMMGAGKTTVGRLLAKALGLPFVDL 30
dNK pfam01712
Deoxynucleoside kinase; This family consists of various deoxynucleoside kinases cytidine EC:2. ...
 8-32 7.75e-03

Deoxynucleoside kinase; This family consists of various deoxynucleoside kinases cytidine EC:2.7.1.74, guanosine EC:2.7.1.113, adenosine EC:2.7.1.76 and thymidine kinase EC:2.7.1.21 (which also phosphorylates deoxyuridine and deoxycytosine.) These enzymes catalyze the production of deoxynucleotide 5'-monophosphate from a deoxynucleoside. Using ATP and yielding ADP in the process.


Pssm-ID: 396326  Cd Length: 201  Bit Score: 36.14  E-value: 7.75e-03
                          10        20
                  ....*....|....*....|....*
gi 489197409    8 LAIDGPSGAGKGTVAGLLARRLGWN 32
Cdd:pfam01712   1 ISIEGNIGAGKSTLTKILSKRLGFK 25
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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