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Conserved domains on  [gi|489195608|ref|WP_003104921|]
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MULTISPECIES: surface-displayed alpha-enolase [Streptococcus]

Protein Classification

phosphopyruvate hydratase( domain architecture ID 11414960)

phosphopyruvate hydratase (enolase) catalyzes the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways

CATH:  3.20.20.120|3.30.390.10
EC:  4.2.1.11
Gene Ontology:  GO:0004634|GO:0000015|GO:0006096|GO:0000287
PubMed:  8994873|8605183
SCOP:  3001064|3000476

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Eno COG0148
Enolase [Carbohydrate transport and metabolism]; Enolase is part of the Pathway/BioSystem: ...
 1-433 0e+00

Enolase [Carbohydrate transport and metabolism]; Enolase is part of the Pathway/BioSystem: Glycolysis


:

Pssm-ID: 439918 [Multi-domain]  Cd Length: 426  Bit Score: 881.66  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489195608   1 MSIITDVYAREVLDSRGNPTLEVEVYTESGAFGRGMVPSGASTGEHEAVELRDGDKSRYNGLGTEKAVDNVNNIIAEAII 80
Cdd:COG0148    1 MSRIEDVHAREILDSRGNPTVEVEVTLEDGAVGRAAVPSGASTGSHEAVELRDGDKSRYLGKGVLKAVENVNEEIAPALI 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489195608  81 GFDVRDQQAIDRAMIALDGTPNKGKLGANAILGVSIAVARAAADYLEVPLYNYLGGFNTKVLPTPMMNIINGGSHSDAPI 160
Cdd:COG0148   81 GMDATDQRAIDRAMIELDGTPNKSRLGANAILGVSLAVAKAAAAALGLPLYRYLGGVNAKTLPVPMMNIINGGAHADNNV 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489195608 161 AFQEFMIMPVGATTFKEALRWGAEVFHALKKILKERGLETAVGDEGGFAPKFDGTEDGVETILKAIEAAGYEAGENgIMI 240
Cdd:COG0148  161 DIQEFMIMPVGAPSFSEALRMGAEVFHALKKVLKEKGLSTAVGDEGGFAPNLKSNEEALELILEAIEKAGYKPGED-IAL 239

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489195608 241 GFDCASSEFYDKerKVYDyakFEGEgGAVRTSAEQIDYLEELVNKYPIITIEDGMDENDWDGWKALTERLGGRVQLVGDD 320
Cdd:COG0148  240 ALDVAASEFYKD--GKYH---LKGE-GKELTSEEMIDYYADLVDKYPIVSIEDGLAEDDWDGWKLLTEKLGDKVQLVGDD 313

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489195608 321 FFVTNTEYLARGIKEEAANSILIKVNQIGTLTETFEAIEMAKEAGFTAVVSHRSGETEDSTIADIAVATNAGQIKTGSLS 400
Cdd:COG0148  314 LFVTNPKRLKKGIEEGAANSILIKVNQIGTLTETLDAIELAKRAGYTAVISHRSGETEDTTIADLAVATNAGQIKTGSPS 393

                        410       420       430
                 ....*....|....*....|....*....|...
gi 489195608 401 RTDRIAKYNQLLRIEDQLGEVAQYKGIKSFYNL 433
Cdd:COG0148  394 RSERVAKYNQLLRIEEELGDAARYAGRSAFKRL 426
 
Name Accession Description Interval E-value
Eno COG0148
Enolase [Carbohydrate transport and metabolism]; Enolase is part of the Pathway/BioSystem: ...
 1-433 0e+00

Enolase [Carbohydrate transport and metabolism]; Enolase is part of the Pathway/BioSystem: Glycolysis


Pssm-ID: 439918 [Multi-domain]  Cd Length: 426  Bit Score: 881.66  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489195608   1 MSIITDVYAREVLDSRGNPTLEVEVYTESGAFGRGMVPSGASTGEHEAVELRDGDKSRYNGLGTEKAVDNVNNIIAEAII 80
Cdd:COG0148    1 MSRIEDVHAREILDSRGNPTVEVEVTLEDGAVGRAAVPSGASTGSHEAVELRDGDKSRYLGKGVLKAVENVNEEIAPALI 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489195608  81 GFDVRDQQAIDRAMIALDGTPNKGKLGANAILGVSIAVARAAADYLEVPLYNYLGGFNTKVLPTPMMNIINGGSHSDAPI 160
Cdd:COG0148   81 GMDATDQRAIDRAMIELDGTPNKSRLGANAILGVSLAVAKAAAAALGLPLYRYLGGVNAKTLPVPMMNIINGGAHADNNV 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489195608 161 AFQEFMIMPVGATTFKEALRWGAEVFHALKKILKERGLETAVGDEGGFAPKFDGTEDGVETILKAIEAAGYEAGENgIMI 240
Cdd:COG0148  161 DIQEFMIMPVGAPSFSEALRMGAEVFHALKKVLKEKGLSTAVGDEGGFAPNLKSNEEALELILEAIEKAGYKPGED-IAL 239

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489195608 241 GFDCASSEFYDKerKVYDyakFEGEgGAVRTSAEQIDYLEELVNKYPIITIEDGMDENDWDGWKALTERLGGRVQLVGDD 320
Cdd:COG0148  240 ALDVAASEFYKD--GKYH---LKGE-GKELTSEEMIDYYADLVDKYPIVSIEDGLAEDDWDGWKLLTEKLGDKVQLVGDD 313

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489195608 321 FFVTNTEYLARGIKEEAANSILIKVNQIGTLTETFEAIEMAKEAGFTAVVSHRSGETEDSTIADIAVATNAGQIKTGSLS 400
Cdd:COG0148  314 LFVTNPKRLKKGIEEGAANSILIKVNQIGTLTETLDAIELAKRAGYTAVISHRSGETEDTTIADLAVATNAGQIKTGSPS 393

                        410       420       430
                 ....*....|....*....|....*....|...
gi 489195608 401 RTDRIAKYNQLLRIEDQLGEVAQYKGIKSFYNL 433
Cdd:COG0148  394 RSERVAKYNQLLRIEEELGDAARYAGRSAFKRL 426
eno PRK00077
enolase; Provisional
 1-434 0e+00

enolase; Provisional


Pssm-ID: 234617 [Multi-domain]  Cd Length: 425  Bit Score: 855.54  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489195608   1 MSIITDVYAREVLDSRGNPTLEVEVYTESGAFGRGMVPSGASTGEHEAVELRDGDKSRYNGLGTEKAVDNVNNIIAEAII 80
Cdd:PRK00077   1 MSKIEDIIAREILDSRGNPTVEVEVTLEDGAFGRAAVPSGASTGEREAVELRDGDKSRYLGKGVLKAVENVNEEIAPALI 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489195608  81 GFDVRDQQAIDRAMIALDGTPNKGKLGANAILGVSIAVARAAADYLEVPLYNYLGGFNTKVLPTPMMNIINGGSHSDAPI 160
Cdd:PRK00077  81 GLDALDQRAIDKAMIELDGTPNKSKLGANAILGVSLAVAKAAADSLGLPLYRYLGGPNAKVLPVPMMNIINGGAHADNNV 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489195608 161 AFQEFMIMPVGATTFKEALRWGAEVFHALKKILKERGLETAVGDEGGFAPKFDGTEDGVETILKAIEAAGYEAGENgIMI 240
Cdd:PRK00077 161 DIQEFMIMPVGAPSFKEALRMGAEVFHTLKKVLKEKGLSTAVGDEGGFAPNLKSNEEALDLILEAIEKAGYKPGED-IAL 239

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489195608 241 GFDCASSEFYDKerKVYDyakFEGEGgavRTSAEQIDYLEELVNKYPIITIEDGMDENDWDGWKALTERLGGRVQLVGDD 320
Cdd:PRK00077 240 ALDCAASEFYKD--GKYV---LEGEG---LTSEEMIDYLAELVDKYPIVSIEDGLDENDWEGWKLLTEKLGDKVQLVGDD 311

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489195608 321 FFVTNTEYLARGIKEEAANSILIKVNQIGTLTETFEAIEMAKEAGFTAVVSHRSGETEDSTIADIAVATNAGQIKTGSLS 400
Cdd:PRK00077 312 LFVTNTKRLKKGIEKGAANSILIKVNQIGTLTETLDAIELAKRAGYTAVVSHRSGETEDTTIADLAVATNAGQIKTGSLS 391

                        410       420       430
                 ....*....|....*....|....*....|....
gi 489195608 401 RTDRIAKYNQLLRIEDQLGEVAQYKGIKSFYNLK 434
Cdd:PRK00077 392 RSERIAKYNQLLRIEEELGDAARYAGKKAFKNLK 425
enolase cd03313
Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of ...
 6-417 0e+00

Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions.


Pssm-ID: 239429 [Multi-domain]  Cd Length: 408  Bit Score: 743.15  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489195608   6 DVYAREVLDSRGNPTLEVEVYTESGAFGRGMVPSGASTGEHEAVELRDGDKSRYNGLGTEKAVDNVNNIIAEAIIGFDVR 85
Cdd:cd03313    1 KIKAREILDSRGNPTVEVEVTTEDGGVGRAAVPSGASTGEHEAVELRDGDKSRYLGKGVLKAVKNVNEIIAPALIGMDVT 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489195608  86 DQQAIDRAMIALDGTPNKGKLGANAILGVSIAVARAAADYLEVPLYNYLGGFNTKVLPTPMMNIINGGSHSDAPIAFQEF 165
Cdd:cd03313   81 DQRAIDKLLIELDGTPNKSKLGANAILGVSLAVAKAAAAALGLPLYRYLGGLAAYVLPVPMFNVINGGAHAGNKLDFQEF 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489195608 166 MIMPVGATTFKEALRWGAEVFHALKKILKERG--LETAVGDEGGFAPKFDGTEDGVETILKAIEAAGYEAGENgIMIGFD 243
Cdd:cd03313  161 MIVPVGAPSFSEALRMGAEVYHTLKKVLKKKGglLATNVGDEGGFAPNLSSNEEALDLLVEAIEKAGYEPGKK-IAIALD 239

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489195608 244 CASSEFYDKERKVYDyakfeGEGGAVRTSAEQIDYLEELVNKYPIITIEDGMDENDWDGWKALTERLGGRVQLVGDDFFV 323
Cdd:cd03313  240 VAASEFYDEGKYVYD-----SDEGKKLTSEELIDYYKELVKKYPIVSIEDPFDEDDWEGWAKLTAKLGDKIQIVGDDLFV 314

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489195608 324 TNTEYLARGIKEEAANSILIKVNQIGTLTETFEAIEMAKEAGFTAVVSHRSGETEDSTIADIAVATNAGQIKTGSLSRTD 403
Cdd:cd03313  315 TNPERLKKGIEKKAANALLIKVNQIGTLTETIEAIKLAKKNGYGVVVSHRSGETEDTFIADLAVALGAGQIKTGAPCRSE 394

                        410
                 ....*....|....
gi 489195608 404 RIAKYNQLLRIEDQ 417
Cdd:cd03313  395 RTAKYNQLLRIEEE 408
eno TIGR01060
phosphopyruvate hydratase; Alternate name: enolase [Energy metabolism, Glycolysis ...
 4-433 0e+00

phosphopyruvate hydratase; Alternate name: enolase [Energy metabolism, Glycolysis/gluconeogenesis]


Pssm-ID: 213580 [Multi-domain]  Cd Length: 425  Bit Score: 727.62  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489195608    4 ITDVYAREVLDSRGNPTLEVEVYTESGAFGRGMVPSGASTGEHEAVELRDGDKSRYNGLGTEKAVDNVNNIIAEAIIGFD 83
Cdd:TIGR01060   1 IVDIRAREILDSRGNPTVEVEVILEDGTFGRAAVPSGASTGEREALELRDGDKKRYLGKGVLKAVENVNEIIAPELIGMD 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489195608   84 VRDQQAIDRAMIALDGTPNKGKLGANAILGVSIAVARAAADYLEVPLYNYLGGFNTKVLPTPMMNIINGGSHSDAPIAFQ 163
Cdd:TIGR01060  81 ATDQREIDQILIELDGTPNKSKLGANAILGVSMAVAKAAADSLGLPLYRYLGGFNAYVLPVPMMNIINGGAHADNNLDFQ 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489195608  164 EFMIMPVGATTFKEALRWGAEVFHALKKILKERGLETAVGDEGGFAPKFDGTEDGVETILKAIEAAGYEAGENgIMIGFD 243
Cdd:TIGR01060 161 EFMIMPVGAPSFREALRMGAEVFHALKKLLKEKGLATGVGDEGGFAPNLASNEEALEIIVEAIEKAGYKPGED-VALALD 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489195608  244 CASSEFYDKERKVYdyaKFEGEGGAvRTSAEQIDYLEELVNKYPIITIEDGMDENDWDGWKALTERLGGRVQLVGDDFFV 323
Cdd:TIGR01060 240 CAASEFYDEEDGKY---VYKGENKQ-LTSEEMIEYYEELVEKYPIISIEDGLSEEDWEGWAELTKRLGDKVQIVGDDLFV 315

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489195608  324 TNTEYLARGIKEEAANSILIKVNQIGTLTETFEAIEMAKEAGFTAVVSHRSGETEDSTIADIAVATNAGQIKTGSLSRTD 403
Cdd:TIGR01060 316 TNTEILREGIEMGVANSILIKPNQIGTLTETLDAIELAKKAGYTAVISHRSGETEDTTIADLAVATNAGQIKTGSLSRSE 395

                         410       420       430
                  ....*....|....*....|....*....|
gi 489195608  404 RIAKYNQLLRIEDQLGEVAQYKGIKSFYNL 433
Cdd:TIGR01060 396 RIAKYNQLLRIEEELGDSARYAGKNSFYRF 425
Enolase_C pfam00113
Enolase, C-terminal TIM barrel domain;
139-433 1.03e-150

Enolase, C-terminal TIM barrel domain;


Pssm-ID: 395063  Cd Length: 296  Bit Score: 429.59  E-value: 1.03e-150
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489195608  139 TKVLPTPMMNIINGGSHSDAPIAFQEFMIMPVGATTFKEALRWGAEVFHALKKILKERG--LETAVGDEGGFAPKFDGTE 216
Cdd:pfam00113   1 SYVLPVPMMNVINGGSHAGNNLAFQEFMILPTGAPSFSEAMRMGAEVYHHLKSVLKAKYgqSATNVGDEGGFAPNLQSNK 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489195608  217 DGVETILKAIEAAGYEAGengIMIGFDCASSEFYDKERKVYDYaKFEGE---GGAVRTSAEQIDYLEELVNKYPIITIED 293
Cdd:pfam00113  81 EALDLIVEAIEKAGYKGK---IKIAMDVASSEFYNKKDGKYDL-DFKGEksdKSKKLTSAQLADLYEELVKKYPIVSIED 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489195608  294 GMDENDWDGWKALTERLGGRVQLVGDDFFVTNTEYLARGIKEEAANSILIKVNQIGTLTETFEAIEMAKEAGFTAVVSHR 373
Cdd:pfam00113 157 PFDEDDWEAWKYLTERLGDKVQIVGDDLTVTNPKRLKTAIEKKIANALLLKVNQIGSLTESIAAVKMAKDAGWGVMVSHR 236

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 489195608  374 SGETEDSTIADIAVATNAGQIKTGSLSRTDRIAKYNQLLRIEDQLGEVAQYKGIKSFYNL 433
Cdd:pfam00113 237 SGETEDTTIADLAVGLNAGQIKTGAPCRSERLAKYNQLLRIEEELGSEAKYAGRSFRKPL 296
 
Name Accession Description Interval E-value
Eno COG0148
Enolase [Carbohydrate transport and metabolism]; Enolase is part of the Pathway/BioSystem: ...
 1-433 0e+00

Enolase [Carbohydrate transport and metabolism]; Enolase is part of the Pathway/BioSystem: Glycolysis


Pssm-ID: 439918 [Multi-domain]  Cd Length: 426  Bit Score: 881.66  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489195608   1 MSIITDVYAREVLDSRGNPTLEVEVYTESGAFGRGMVPSGASTGEHEAVELRDGDKSRYNGLGTEKAVDNVNNIIAEAII 80
Cdd:COG0148    1 MSRIEDVHAREILDSRGNPTVEVEVTLEDGAVGRAAVPSGASTGSHEAVELRDGDKSRYLGKGVLKAVENVNEEIAPALI 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489195608  81 GFDVRDQQAIDRAMIALDGTPNKGKLGANAILGVSIAVARAAADYLEVPLYNYLGGFNTKVLPTPMMNIINGGSHSDAPI 160
Cdd:COG0148   81 GMDATDQRAIDRAMIELDGTPNKSRLGANAILGVSLAVAKAAAAALGLPLYRYLGGVNAKTLPVPMMNIINGGAHADNNV 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489195608 161 AFQEFMIMPVGATTFKEALRWGAEVFHALKKILKERGLETAVGDEGGFAPKFDGTEDGVETILKAIEAAGYEAGENgIMI 240
Cdd:COG0148  161 DIQEFMIMPVGAPSFSEALRMGAEVFHALKKVLKEKGLSTAVGDEGGFAPNLKSNEEALELILEAIEKAGYKPGED-IAL 239

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489195608 241 GFDCASSEFYDKerKVYDyakFEGEgGAVRTSAEQIDYLEELVNKYPIITIEDGMDENDWDGWKALTERLGGRVQLVGDD 320
Cdd:COG0148  240 ALDVAASEFYKD--GKYH---LKGE-GKELTSEEMIDYYADLVDKYPIVSIEDGLAEDDWDGWKLLTEKLGDKVQLVGDD 313

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489195608 321 FFVTNTEYLARGIKEEAANSILIKVNQIGTLTETFEAIEMAKEAGFTAVVSHRSGETEDSTIADIAVATNAGQIKTGSLS 400
Cdd:COG0148  314 LFVTNPKRLKKGIEEGAANSILIKVNQIGTLTETLDAIELAKRAGYTAVISHRSGETEDTTIADLAVATNAGQIKTGSPS 393

                        410       420       430
                 ....*....|....*....|....*....|...
gi 489195608 401 RTDRIAKYNQLLRIEDQLGEVAQYKGIKSFYNL 433
Cdd:COG0148  394 RSERVAKYNQLLRIEEELGDAARYAGRSAFKRL 426
eno PRK00077
enolase; Provisional
 1-434 0e+00

enolase; Provisional


Pssm-ID: 234617 [Multi-domain]  Cd Length: 425  Bit Score: 855.54  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489195608   1 MSIITDVYAREVLDSRGNPTLEVEVYTESGAFGRGMVPSGASTGEHEAVELRDGDKSRYNGLGTEKAVDNVNNIIAEAII 80
Cdd:PRK00077   1 MSKIEDIIAREILDSRGNPTVEVEVTLEDGAFGRAAVPSGASTGEREAVELRDGDKSRYLGKGVLKAVENVNEEIAPALI 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489195608  81 GFDVRDQQAIDRAMIALDGTPNKGKLGANAILGVSIAVARAAADYLEVPLYNYLGGFNTKVLPTPMMNIINGGSHSDAPI 160
Cdd:PRK00077  81 GLDALDQRAIDKAMIELDGTPNKSKLGANAILGVSLAVAKAAADSLGLPLYRYLGGPNAKVLPVPMMNIINGGAHADNNV 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489195608 161 AFQEFMIMPVGATTFKEALRWGAEVFHALKKILKERGLETAVGDEGGFAPKFDGTEDGVETILKAIEAAGYEAGENgIMI 240
Cdd:PRK00077 161 DIQEFMIMPVGAPSFKEALRMGAEVFHTLKKVLKEKGLSTAVGDEGGFAPNLKSNEEALDLILEAIEKAGYKPGED-IAL 239

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489195608 241 GFDCASSEFYDKerKVYDyakFEGEGgavRTSAEQIDYLEELVNKYPIITIEDGMDENDWDGWKALTERLGGRVQLVGDD 320
Cdd:PRK00077 240 ALDCAASEFYKD--GKYV---LEGEG---LTSEEMIDYLAELVDKYPIVSIEDGLDENDWEGWKLLTEKLGDKVQLVGDD 311

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489195608 321 FFVTNTEYLARGIKEEAANSILIKVNQIGTLTETFEAIEMAKEAGFTAVVSHRSGETEDSTIADIAVATNAGQIKTGSLS 400
Cdd:PRK00077 312 LFVTNTKRLKKGIEKGAANSILIKVNQIGTLTETLDAIELAKRAGYTAVVSHRSGETEDTTIADLAVATNAGQIKTGSLS 391

                        410       420       430
                 ....*....|....*....|....*....|....
gi 489195608 401 RTDRIAKYNQLLRIEDQLGEVAQYKGIKSFYNLK 434
Cdd:PRK00077 392 RSERIAKYNQLLRIEEELGDAARYAGKKAFKNLK 425
enolase cd03313
Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of ...
 6-417 0e+00

Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions.


Pssm-ID: 239429 [Multi-domain]  Cd Length: 408  Bit Score: 743.15  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489195608   6 DVYAREVLDSRGNPTLEVEVYTESGAFGRGMVPSGASTGEHEAVELRDGDKSRYNGLGTEKAVDNVNNIIAEAIIGFDVR 85
Cdd:cd03313    1 KIKAREILDSRGNPTVEVEVTTEDGGVGRAAVPSGASTGEHEAVELRDGDKSRYLGKGVLKAVKNVNEIIAPALIGMDVT 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489195608  86 DQQAIDRAMIALDGTPNKGKLGANAILGVSIAVARAAADYLEVPLYNYLGGFNTKVLPTPMMNIINGGSHSDAPIAFQEF 165
Cdd:cd03313   81 DQRAIDKLLIELDGTPNKSKLGANAILGVSLAVAKAAAAALGLPLYRYLGGLAAYVLPVPMFNVINGGAHAGNKLDFQEF 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489195608 166 MIMPVGATTFKEALRWGAEVFHALKKILKERG--LETAVGDEGGFAPKFDGTEDGVETILKAIEAAGYEAGENgIMIGFD 243
Cdd:cd03313  161 MIVPVGAPSFSEALRMGAEVYHTLKKVLKKKGglLATNVGDEGGFAPNLSSNEEALDLLVEAIEKAGYEPGKK-IAIALD 239

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489195608 244 CASSEFYDKERKVYDyakfeGEGGAVRTSAEQIDYLEELVNKYPIITIEDGMDENDWDGWKALTERLGGRVQLVGDDFFV 323
Cdd:cd03313  240 VAASEFYDEGKYVYD-----SDEGKKLTSEELIDYYKELVKKYPIVSIEDPFDEDDWEGWAKLTAKLGDKIQIVGDDLFV 314

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489195608 324 TNTEYLARGIKEEAANSILIKVNQIGTLTETFEAIEMAKEAGFTAVVSHRSGETEDSTIADIAVATNAGQIKTGSLSRTD 403
Cdd:cd03313  315 TNPERLKKGIEKKAANALLIKVNQIGTLTETIEAIKLAKKNGYGVVVSHRSGETEDTFIADLAVALGAGQIKTGAPCRSE 394

                        410
                 ....*....|....
gi 489195608 404 RIAKYNQLLRIEDQ 417
Cdd:cd03313  395 RTAKYNQLLRIEEE 408
eno TIGR01060
phosphopyruvate hydratase; Alternate name: enolase [Energy metabolism, Glycolysis ...
 4-433 0e+00

phosphopyruvate hydratase; Alternate name: enolase [Energy metabolism, Glycolysis/gluconeogenesis]


Pssm-ID: 213580 [Multi-domain]  Cd Length: 425  Bit Score: 727.62  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489195608    4 ITDVYAREVLDSRGNPTLEVEVYTESGAFGRGMVPSGASTGEHEAVELRDGDKSRYNGLGTEKAVDNVNNIIAEAIIGFD 83
Cdd:TIGR01060   1 IVDIRAREILDSRGNPTVEVEVILEDGTFGRAAVPSGASTGEREALELRDGDKKRYLGKGVLKAVENVNEIIAPELIGMD 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489195608   84 VRDQQAIDRAMIALDGTPNKGKLGANAILGVSIAVARAAADYLEVPLYNYLGGFNTKVLPTPMMNIINGGSHSDAPIAFQ 163
Cdd:TIGR01060  81 ATDQREIDQILIELDGTPNKSKLGANAILGVSMAVAKAAADSLGLPLYRYLGGFNAYVLPVPMMNIINGGAHADNNLDFQ 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489195608  164 EFMIMPVGATTFKEALRWGAEVFHALKKILKERGLETAVGDEGGFAPKFDGTEDGVETILKAIEAAGYEAGENgIMIGFD 243
Cdd:TIGR01060 161 EFMIMPVGAPSFREALRMGAEVFHALKKLLKEKGLATGVGDEGGFAPNLASNEEALEIIVEAIEKAGYKPGED-VALALD 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489195608  244 CASSEFYDKERKVYdyaKFEGEGGAvRTSAEQIDYLEELVNKYPIITIEDGMDENDWDGWKALTERLGGRVQLVGDDFFV 323
Cdd:TIGR01060 240 CAASEFYDEEDGKY---VYKGENKQ-LTSEEMIEYYEELVEKYPIISIEDGLSEEDWEGWAELTKRLGDKVQIVGDDLFV 315

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489195608  324 TNTEYLARGIKEEAANSILIKVNQIGTLTETFEAIEMAKEAGFTAVVSHRSGETEDSTIADIAVATNAGQIKTGSLSRTD 403
Cdd:TIGR01060 316 TNTEILREGIEMGVANSILIKPNQIGTLTETLDAIELAKKAGYTAVISHRSGETEDTTIADLAVATNAGQIKTGSLSRSE 395

                         410       420       430
                  ....*....|....*....|....*....|
gi 489195608  404 RIAKYNQLLRIEDQLGEVAQYKGIKSFYNL 433
Cdd:TIGR01060 396 RIAKYNQLLRIEEELGDSARYAGKNSFYRF 425
PTZ00081 PTZ00081
enolase; Provisional
 1-426 0e+00

enolase; Provisional


Pssm-ID: 240259 [Multi-domain]  Cd Length: 439  Bit Score: 578.16  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489195608   1 MSIITDVYAREVLDSRGNPTLEVEVYTESGAFgRGMVPSGASTGEHEAVELRDGDKSRYNGLGTEKAVDNVNNIIAEAII 80
Cdd:PTZ00081   1 MSTIKSIKAREILDSRGNPTVEVDLTTEKGVF-RAAVPSGASTGIYEALELRDGDKSRYLGKGVLKAVENVNEIIAPALI 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489195608  81 GFDVRDQQAIDRAMI-ALDGTPN-----KGKLGANAILGVSIAVARAAADYLEVPLYNYLGGFNTK-----VLPTPMMNI 149
Cdd:PTZ00081  80 GKDVTDQKKLDKLMVeQLDGTKNewgwcKSKLGANAILAVSMAVARAAAAAKGVPLYKYLAQLAGKptdkfVLPVPCFNV 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489195608 150 INGGSHSDAPIAFQEFMIMPVGATTFKEALRWGAEVFHALKKILKER-GLE-TAVGDEGGFAPKFDGTEDGVETILKAIE 227
Cdd:PTZ00081 160 INGGKHAGNKLAFQEFMIAPVGAPSFKEALRMGAEVYHSLKSVIKKKyGLDaTNVGDEGGFAPNIKDPEEALDLLVEAIK 239

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489195608 228 AAGYEAGengIMIGFDCASSEFYDKERKVYD--YAKFEGEGGAVRTSAEQIDYLEELVNKYPIITIEDGMDENDWDGWKA 305
Cdd:PTZ00081 240 KAGYEGK---VKICMDVAASEFYDKEKKVYDldFKNPNNDKSNKLTGEELVELYLDLVKKYPIVSIEDPFDQDDWEAYAK 316

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489195608 306 LTERLGGRVQLVGDDFFVTNTEYLARGIKEEAANSILIKVNQIGTLTETFEAIEMAKEAGFTAVVSHRSGETEDSTIADI 385
Cdd:PTZ00081 317 LTAAIGQKVQIVGDDLLVTNPTRIKKAIEKKACNALLLKVNQIGTVTEAIEAAKLAQKNGWGVMVSHRSGETEDTFIADL 396

                        410       420       430       440
                 ....*....|....*....|....*....|....*....|.
gi 489195608 386 AVATNAGQIKTGSLSRTDRIAKYNQLLRIEDQLGEVAQYKG 426
Cdd:PTZ00081 397 VVGLGTGQIKTGAPCRSERLAKYNQLLRIEEELGSNAVYAG 437
PLN00191 PLN00191
enolase
 1-426 0e+00

enolase


Pssm-ID: 215095 [Multi-domain]  Cd Length: 457  Bit Score: 540.84  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489195608   1 MSIITDVYAREVLDSRGNPTLEVEVYTESGAFgRGMVPSGASTGEHEAVELRDGDKsRYNGLGTEKAVDNVNNIIAEAII 80
Cdd:PLN00191  25 MATITKVKARQIIDSRGNPTVEVDLHTSKGMF-RAAVPSGASTGIYEALELRDGDK-DYLGKGVLKAVKNVNEIIAPALI 102

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489195608  81 GFDVRDQQAIDRAMIALDGTPNKGKLGANAILGVSIAVARAAADYLEVPLYNY---LGGFNTKVLPTPMMNIINGGSHSD 157
Cdd:PLN00191 103 GMDPTDQTQIDNFMLELDGTPNKGKLGANAILAVSLAVCKAGAAEKGVPLYKHiadLAGNKKLVLPVPAFNVINGGSHAG 182

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489195608 158 APIAFQEFMIMPVGATTFKEALRWGAEVFHALKKILKER--GLETAVGDEGGFAPKFDGTEDGVETILKAIEAAGYeage 235
Cdd:PLN00191 183 NKLAMQEFMILPVGASSFKEAMQMGSEVYHHLKAVIKKKygQDACNVGDEGGFAPNIQDNKEGLELLKEAIEKAGY---- 258

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489195608 236 NG-IMIGFDCASSEFYDKERKvYD--YAKFEGEGGAVRTSAEQIDYLEELVNKYPIITIEDGMDENDWDGWKALTERlgG 312
Cdd:PLN00191 259 TGkIKIGMDVAASEFYTKDKK-YDldFKEENNDGSNKKSGDELIDLYKEFVSDYPIVSIEDPFDQDDWEHWAKLTSL--E 335

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489195608 313 RVQLVGDDFFVTNTEYLARGIKEEAANSILIKVNQIGTLTETFEAIEMAKEAGFTAVVSHRSGETEDSTIADIAVATNAG 392
Cdd:PLN00191 336 DVQIVGDDLLVTNPKRVAKAIQEKACNALLLKVNQIGTVTESIEAVKMSKAAGWGVMTSHRSGETEDSFIADLAVGLATG 415

                        410       420       430
                 ....*....|....*....|....*....|....
gi 489195608 393 QIKTGSLSRTDRIAKYNQLLRIEDQLGEVAQYKG 426
Cdd:PLN00191 416 QIKTGAPCRSERLAKYNQLLRIEEELGDEAVYAG 449
Enolase_C pfam00113
Enolase, C-terminal TIM barrel domain;
139-433 1.03e-150

Enolase, C-terminal TIM barrel domain;


Pssm-ID: 395063  Cd Length: 296  Bit Score: 429.59  E-value: 1.03e-150
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489195608  139 TKVLPTPMMNIINGGSHSDAPIAFQEFMIMPVGATTFKEALRWGAEVFHALKKILKERG--LETAVGDEGGFAPKFDGTE 216
Cdd:pfam00113   1 SYVLPVPMMNVINGGSHAGNNLAFQEFMILPTGAPSFSEAMRMGAEVYHHLKSVLKAKYgqSATNVGDEGGFAPNLQSNK 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489195608  217 DGVETILKAIEAAGYEAGengIMIGFDCASSEFYDKERKVYDYaKFEGE---GGAVRTSAEQIDYLEELVNKYPIITIED 293
Cdd:pfam00113  81 EALDLIVEAIEKAGYKGK---IKIAMDVASSEFYNKKDGKYDL-DFKGEksdKSKKLTSAQLADLYEELVKKYPIVSIED 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489195608  294 GMDENDWDGWKALTERLGGRVQLVGDDFFVTNTEYLARGIKEEAANSILIKVNQIGTLTETFEAIEMAKEAGFTAVVSHR 373
Cdd:pfam00113 157 PFDEDDWEAWKYLTERLGDKVQIVGDDLTVTNPKRLKTAIEKKIANALLLKVNQIGSLTESIAAVKMAKDAGWGVMVSHR 236

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 489195608  374 SGETEDSTIADIAVATNAGQIKTGSLSRTDRIAKYNQLLRIEDQLGEVAQYKGIKSFYNL 433
Cdd:pfam00113 237 SGETEDTTIADLAVGLNAGQIKTGAPCRSERLAKYNQLLRIEEELGSEAKYAGRSFRKPL 296
Enolase_N pfam03952
Enolase, N-terminal domain;
4-134 3.19e-91

Enolase, N-terminal domain;


Pssm-ID: 461105 [Multi-domain]  Cd Length: 131  Bit Score: 271.56  E-value: 3.19e-91
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489195608    4 ITDVYAREVLDSRGNPTLEVEVYTESGAFGRGMVPSGASTGEHEAVELRDGDKSRYNGLGTEKAVDNVNNIIAEAIIGFD 83
Cdd:pfam03952   1 ITKVKAREILDSRGNPTVEVEVTLEDGTFGRAAVPSGASTGEHEAVELRDGDKSRYGGKGVLKAVENVNEIIAPALIGMD 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 489195608   84 VRDQQAIDRAMIALDGTPNKGKLGANAILGVSIAVARAAADYLEVPLYNYL 134
Cdd:pfam03952  81 ATDQRAIDRALIELDGTENKSKLGANAILGVSLAVAKAAAAALGLPLYRYL 131
PRK08350 PRK08350
hypothetical protein; Provisional
 1-420 1.23e-21

hypothetical protein; Provisional


Pssm-ID: 169397 [Multi-domain]  Cd Length: 341  Bit Score: 95.26  E-value: 1.23e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489195608   1 MSIITDVYAREVLDSRGNPTLEVEVYTESGaFGRGMVPSGASTGEHEAVELRdgdksrynglgtekAVDNVNNIIAEAII 80
Cdd:PRK08350   1 MTVIENIIGRVAVLRGGKYSVEVDVITDSG-FGRFAAPIDENPSLYIAEAHR--------------AVSEVDEIIGPELI 65

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489195608  81 GFDVRDQQAIDRAMIALDGTPNKGKLGANAILGVSIAVARAAADYLEVPLYNYLGGFNTKVLPTPMMNIINgGSHSDAPI 160
Cdd:PRK08350  66 GFDASEQELIDSYLWEIDGTEDFSHIGANTALAVSVAVAKAAANSKNMPLYSYIGGTFTTELPVPILEFAE-DENFEYYV 144

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489195608 161 AFQEFMIMpvgattfkealrwgAEVFHALKKILKErgletavgdeggfapkfdGTEDGVETILKAIEAAGYEAGengimi 240
Cdd:PRK08350 145 LVRDLMEI--------------TDVVDAVNKILEN------------------SKEVSLEGLSKASEKAGDELG------ 186

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489195608 241 gfdcassefydkerkvydyakFEGEGGAVRTSAEQIDYLEELVNKYPIITIEDGMDEndwdgwKALTERLGGRVQLVGDD 320
Cdd:PRK08350 187 ---------------------LEVALGIAQKREMETEKVLNLVEDNNIAYIKPIGDE------ELFLELIAGTHGVFIDG 239

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489195608 321 ffvtntEYLARG---IKEEAANSILIKVNQIGTLTETFEAIEMAKEAGFTAVVSHRSGETEDSTIADIAVATNAGQIktg 397
Cdd:PRK08350 240 ------EYLFRTrniLDRRYYNALSIKPINLGTLTDLYNLVNDVKSERITPILAEAKYESADEALPHLAVGLRCPAM--- 310

                        410       420
                 ....*....|....*....|...
gi 489195608 398 sLSRTDRIAKYNQLLRIEDQLGE 420
Cdd:PRK08350 311 -LIHKDSVEKINELNRIAEDLGE 332
enolase_like cd00308
Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is ...
 274-396 1.10e-13

Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion. Enolase superfamily contains different enzymes, like enolases, glutarate-, fucanate- and galactonate dehydratases, o-succinylbenzoate synthase, N-acylamino acid racemase, L-alanine-DL-glutamate epimerase, mandelate racemase, muconate lactonizing enzyme and 3-methylaspartase.


Pssm-ID: 238188 [Multi-domain]  Cd Length: 229  Bit Score: 70.05  E-value: 1.10e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489195608 274 EQIDYLEELvNKYPIITIEDGMDENDWDGWKALTERLGgrVQLVGDDFFVTNtEYLARGIKEEAANSILIKVNQIGTLTE 353
Cdd:cd00308  109 EAIRLIRAL-EKYGLAWIEEPCAPDDLEGYAALRRRTG--IPIAADESVTTV-DDALEALELGAVDILQIKPTRVGGLTE 184

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 489195608 354 TFEAIEMAKEAGFTAVVSHRSG-ETEDSTIADIAVAT-NAGQIKT 396
Cdd:cd00308  185 SRRAADLAEAFGIRVMVHGTLEsSIGTAAALHLAAALpNDRAIET 229
PTZ00378 PTZ00378
hypothetical protein; Provisional
 50-418 1.23e-10

hypothetical protein; Provisional


Pssm-ID: 173571 [Multi-domain]  Cd Length: 518  Bit Score: 63.36  E-value: 1.23e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489195608  50 ELRDGDkSRYNGLGTEKAVDNVNNIIAEAIIGFDVRDQQAIDRAMIALDGTPNKGKLGANAILGVSIAVARAAADYLEVP 129
Cdd:PTZ00378  91 GERDGE-ADATLDPAEYTTEALQNSYFPRLLQLGARDQREFDSTLRAALSTSPLANVGSAVQWALSIVASLAAARCRSVP 169

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489195608 130 LYNYL-------GGFNTKVLPTPMMNIINGGSHSDAPIAFQEFMIMPV--GATTFKEALRwgaEVFHALKKILKERglET 200
Cdd:PTZ00378 170 LFQYLralfgslTSVETFSMPQLCITFFGPGNPSTARLALKSVLFSPVmpSGTVLRERMQ---KIFAAFHHFCQSH--NS 244

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489195608 201 AVGDEGGFApkFDGTE---DGVETILKAIEAAGYEAGENgIMIGFDCASSEFYDKERKVYD--------------YAKFE 263
Cdd:PTZ00378 245 SVRSDGSLH--WDGFAnltDAVKLATEALRAVQLTPGTD-VCLGLRMAASTTRVPATAVADggawkeakddcevlYSLFP 321

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489195608 264 GEggAVRTSAEQIDYLEELVNKYP--IITIEDGMDENDWDGWKALTERLGGRVQLVGDDFFvTNTEY--LARGIKEEAAN 339
Cdd:PTZ00378 322 GE--PDVTGDQLSEYVREQLQAVPdiVVYVEDTHCDEDTFGLQRLQAALGDSIVLSGVDVY-ARSEYkkVESGLRGLWTS 398

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489195608 340 SILIKVNQIGTLTETFEAIEMAKE-AGFTAVVSHRSGETEDSTIADIAVATNAGQIKTGSLSRTDRIAKYNQLLRIEDQL 418
Cdd:PTZ00378 399 NIVLNPCAIGTLSDVVEIVRAVGEdEGRAVTVLVQTLAGNAATAAHLAVAMGARFLCSGGLFSAHQCEVVSQLASRQDEL 478
RspA COG4948
L-alanine-DL-glutamate epimerase or related enzyme of enolase superfamily [Cell wall/membrane ...
 23-391 4.10e-09

L-alanine-DL-glutamate epimerase or related enzyme of enolase superfamily [Cell wall/membrane/envelope biogenesis, General function prediction only]; L-alanine-DL-glutamate epimerase or related enzyme of enolase superfamily is part of the Pathway/BioSystem: Non-phosphorylated Entner-Doudoroff pathway


Pssm-ID: 443975 [Multi-domain]  Cd Length: 359  Bit Score: 57.91  E-value: 4.10e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489195608  23 VEVYTESGAFGRGmvpsgastgehEAVelrdgdksrYNGLGTEKAVDNVNNIIAEAIIGFDVRDQQAIDRAMIALDGTPN 102
Cdd:COG4948   34 VRVETDDGITGWG-----------EAV---------PGGTGAEAVAAALEEALAPLLIGRDPLDIEALWQRLYRALPGNP 93

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489195608 103 kgklgaNAILGVSIAVARAAADYLEVPLYNYLGGFNTKVLPTpmmniinGGSHSDAPIafqefmimpvgATTFKEALRWG 182
Cdd:COG4948   94 ------AAKAAVDMALWDLLGKALGVPVYQLLGGKVRDRVPV-------YATLGIDTP-----------EEMAEEAREAV 149

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489195608 183 AEVFHALK-KIlkergletavgdeGGFAPKFDgtedgvETILKAI-EAAGYEAgenGIMIGFDCAssefydkerkvYDYA 260
Cdd:COG4948  150 ARGFRALKlKV-------------GGPDPEED------VERVRAVrEAVGPDA---RLRVDANGA-----------WTLE 196

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489195608 261 kfegegGAVRTSAEqidyLEElvnkYPIITIEDGMDENDWDGWKALTERLggRVQLVGDDFFVTNTEyLARGIKEEAANS 340
Cdd:COG4948  197 ------EAIRLLRA----LED----LGLEWIEQPLPAEDLEGLAELRRAT--PVPIAADESLTSRAD-FRRLIEAGAVDI 259

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|.
gi 489195608 341 ILIKVNQIGTLTETFEAIEMAKEAGFTaVVSHRSGETedstiaDIAVATNA 391
Cdd:COG4948  260 VNIKLSKVGGLTEALRIAALAEAHGVP-VMPHCMLES------GIGLAAAL 303
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
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