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Conserved domains on  [gi|489189943|ref|WP_003099318|]
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MULTISPECIES: NAD(P)/FAD-dependent oxidoreductase [Pseudomonas]

Protein Classification

NAD(P)/FAD-dependent oxidoreductase( domain architecture ID 11465281)

NAD(P)/FAD-dependent oxidoreductase such as polyamine oxidase (PAO), flavin-containing monoamine oxidases (MAOs), D-amino acid dehydrogenase, and linoleic acid isomerase

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
COG3380 COG3380
Predicted NAD/FAD-dependent oxidoreductase [General function prediction only];
1-327 7.29e-146

Predicted NAD/FAD-dependent oxidoreductase [General function prediction only];


:

Pssm-ID: 442607 [Multi-domain]  Cd Length: 331  Bit Score: 413.89  E-value: 7.29e-146
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489189943   1 MSVPIAIIGTGIAGLSAAHALRSAGQTVQLFDKGHGSGGRMASKRSEAGTLDLGAQYFTARDRRFLDALQHWREEGWVDE 80
Cdd:COG3380    2 SMPDIAIIGAGIAGLAAARALQDAGHEVTVFEKSRGVGGRMATRRLDGGRFDHGAQYFTARDPRFQALVEEWLAAGLVAP 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489189943  81 WKPALYQYR-DGQLSPSPDEQPRWVGIPRMSAITRALLTDLQVVFSCRITEVFRGKQHWHLQDAEGQNHGPFNQVLIAIP 159
Cdd:COG3380   82 WTFDFVVLDaDGLVSPRDDGEPRYVGVPGMNALAKHLAAGLDVRLGTRVTALERDGDGWRLTDEDGEEYGPFDAVVLAIP 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489189943 160 APQATPLLASV--PKLAATAASVVMEPTWAVALGFREVLDTPVQGCFVHDSPIAWLACNRSKPGRDTTlDTWVLHATSQW 237
Cdd:COG3380  162 APQAAALLEPSlaPELAAALASVRYRPCWAVMLGFDQPLDPDWDAAFVDDGPLAWIARDSSKPGRPGE-EAWVLHASPEW 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489189943 238 SRQHIDMAKEDVVEHLRCAFAEVIGCAVPEAAFSIAHRWLYARPAEAHQWGALGDPDLGIYACGDWCSSGRVEGAWLSGQ 317
Cdd:COG3380  241 SREHLDDDPEEVAAALLAAFAELLGLPLAEPDWAQAHRWRYALPEAPLGAPFLWDADLGLGLCGDWCAGGRVEGAWLSGL 320

                        330
                 ....*....|
gi 489189943 318 EAARRLLEHL 327
Cdd:COG3380  321 ALARALLARL 330
 
Name Accession Description Interval E-value
COG3380 COG3380
Predicted NAD/FAD-dependent oxidoreductase [General function prediction only];
1-327 7.29e-146

Predicted NAD/FAD-dependent oxidoreductase [General function prediction only];


Pssm-ID: 442607 [Multi-domain]  Cd Length: 331  Bit Score: 413.89  E-value: 7.29e-146
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489189943   1 MSVPIAIIGTGIAGLSAAHALRSAGQTVQLFDKGHGSGGRMASKRSEAGTLDLGAQYFTARDRRFLDALQHWREEGWVDE 80
Cdd:COG3380    2 SMPDIAIIGAGIAGLAAARALQDAGHEVTVFEKSRGVGGRMATRRLDGGRFDHGAQYFTARDPRFQALVEEWLAAGLVAP 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489189943  81 WKPALYQYR-DGQLSPSPDEQPRWVGIPRMSAITRALLTDLQVVFSCRITEVFRGKQHWHLQDAEGQNHGPFNQVLIAIP 159
Cdd:COG3380   82 WTFDFVVLDaDGLVSPRDDGEPRYVGVPGMNALAKHLAAGLDVRLGTRVTALERDGDGWRLTDEDGEEYGPFDAVVLAIP 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489189943 160 APQATPLLASV--PKLAATAASVVMEPTWAVALGFREVLDTPVQGCFVHDSPIAWLACNRSKPGRDTTlDTWVLHATSQW 237
Cdd:COG3380  162 APQAAALLEPSlaPELAAALASVRYRPCWAVMLGFDQPLDPDWDAAFVDDGPLAWIARDSSKPGRPGE-EAWVLHASPEW 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489189943 238 SRQHIDMAKEDVVEHLRCAFAEVIGCAVPEAAFSIAHRWLYARPAEAHQWGALGDPDLGIYACGDWCSSGRVEGAWLSGQ 317
Cdd:COG3380  241 SREHLDDDPEEVAAALLAAFAELLGLPLAEPDWAQAHRWRYALPEAPLGAPFLWDADLGLGLCGDWCAGGRVEGAWLSGL 320

                        330
                 ....*....|
gi 489189943 318 EAARRLLEHL 327
Cdd:COG3380  321 ALARALLARL 330
NAD_binding_8 pfam13450
NAD(P)-binding Rossmann-like domain;
7-69 7.32e-14

NAD(P)-binding Rossmann-like domain;


Pssm-ID: 433218 [Multi-domain]  Cd Length: 67  Bit Score: 65.63  E-value: 7.32e-14
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 489189943    7 IIGTGIAGLSAAHALRSAGQTVQLFDKGHGSGGRMASKRSEAGTLDLGAQYFTARD----RRFLDAL 69
Cdd:pfam13450   1 IVGAGLAGLVAAALLAKRGFRVLVLEKRDRLGGNAYSYRVPGYVFDYGAHIFHGSDepnvRDLLDEL 67
PRK11883 PRK11883
protoporphyrinogen oxidase; Reviewed
 5-61 2.37e-07

protoporphyrinogen oxidase; Reviewed


Pssm-ID: 237009 [Multi-domain]  Cd Length: 451  Bit Score: 51.77  E-value: 2.37e-07
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 489189943   5 IAIIGTGIAGLSAAHALRSAGQ--TVQLFDKGHGSGGRMASKRSEAGTLDLGAQYFTAR 61
Cdd:PRK11883   3 VAIIGGGITGLSAAYRLHKKGPdaDITLLEASDRLGGKIQTVRKDGFPIELGPESFLAR 61
 
Name Accession Description Interval E-value
COG3380 COG3380
Predicted NAD/FAD-dependent oxidoreductase [General function prediction only];
1-327 7.29e-146

Predicted NAD/FAD-dependent oxidoreductase [General function prediction only];


Pssm-ID: 442607 [Multi-domain]  Cd Length: 331  Bit Score: 413.89  E-value: 7.29e-146
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489189943   1 MSVPIAIIGTGIAGLSAAHALRSAGQTVQLFDKGHGSGGRMASKRSEAGTLDLGAQYFTARDRRFLDALQHWREEGWVDE 80
Cdd:COG3380    2 SMPDIAIIGAGIAGLAAARALQDAGHEVTVFEKSRGVGGRMATRRLDGGRFDHGAQYFTARDPRFQALVEEWLAAGLVAP 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489189943  81 WKPALYQYR-DGQLSPSPDEQPRWVGIPRMSAITRALLTDLQVVFSCRITEVFRGKQHWHLQDAEGQNHGPFNQVLIAIP 159
Cdd:COG3380   82 WTFDFVVLDaDGLVSPRDDGEPRYVGVPGMNALAKHLAAGLDVRLGTRVTALERDGDGWRLTDEDGEEYGPFDAVVLAIP 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489189943 160 APQATPLLASV--PKLAATAASVVMEPTWAVALGFREVLDTPVQGCFVHDSPIAWLACNRSKPGRDTTlDTWVLHATSQW 237
Cdd:COG3380  162 APQAAALLEPSlaPELAAALASVRYRPCWAVMLGFDQPLDPDWDAAFVDDGPLAWIARDSSKPGRPGE-EAWVLHASPEW 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489189943 238 SRQHIDMAKEDVVEHLRCAFAEVIGCAVPEAAFSIAHRWLYARPAEAHQWGALGDPDLGIYACGDWCSSGRVEGAWLSGQ 317
Cdd:COG3380  241 SREHLDDDPEEVAAALLAAFAELLGLPLAEPDWAQAHRWRYALPEAPLGAPFLWDADLGLGLCGDWCAGGRVEGAWLSGL 320

                        330
                 ....*....|
gi 489189943 318 EAARRLLEHL 327
Cdd:COG3380  321 ALARALLARL 330
NAD_binding_8 pfam13450
NAD(P)-binding Rossmann-like domain;
7-69 7.32e-14

NAD(P)-binding Rossmann-like domain;


Pssm-ID: 433218 [Multi-domain]  Cd Length: 67  Bit Score: 65.63  E-value: 7.32e-14
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 489189943    7 IIGTGIAGLSAAHALRSAGQTVQLFDKGHGSGGRMASKRSEAGTLDLGAQYFTARD----RRFLDAL 69
Cdd:pfam13450   1 IVGAGLAGLVAAALLAKRGFRVLVLEKRDRLGGNAYSYRVPGYVFDYGAHIFHGSDepnvRDLLDEL 67
YobN COG1231
Monoamine oxidase [Amino acid transport and metabolism];
5-327 1.33e-11

Monoamine oxidase [Amino acid transport and metabolism];


Pssm-ID: 440844 [Multi-domain]  Cd Length: 440  Bit Score: 64.94  E-value: 1.33e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489189943   5 IAIIGTGIAGLSAAHALRSAGQTVQLFDKGHGSGGRMASKRSEAG--TLDLGAQYFTARDRRFL---------------- 66
Cdd:COG1231   10 VVIVGAGLAGLAAARELRKAGLDVTVLEARDRVGGRVWTLRFGDDglYAELGAMRIPPSHTNLLalarelglplepfpne 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489189943  67 -------------------------------------DALQHW----------------REEGWVDEWKPALYQYRDGQL 93
Cdd:COG1231   90 ngnallylggkrvrageiaadlrgvaellakllralaAALDPWahpaaeldreslaewlRRNGASPSARRLLGLLGAGEY 169

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489189943  94 SPSPDEQP--------RWVGIPR--------MSAITRALLTDL--QVVFSCRITEVFRGKQHWHLQDAEGQNHGpFNQVL 155
Cdd:COG1231  170 GADPDELSlldllryaASAGGGAqqfrivggMDQLPRALAAELgdRIRLGAPVTRIRQDGDGVTVTTDDGGTVR-ADAVI 248

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489189943 156 IAIPapqaTPLLASV-------PKLAATAASVVMEPTWAVALGFREVL---DTPVQGCFVHDSPIAWLACNRskPGRDTT 225
Cdd:COG1231  249 VTVP----PSVLRRIefdpplpAAKRAAIQRLPYGAAIKVFLQFDRPFweeDGLYGGISLTDLPIRQTWYPS--NGPDGG 322

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489189943 226 LDTWVLHATSQWSRQHIDMAKEDVVEHLRCAFAEVIGCAVPEAAFSIAHRWL----------YARPAEAHQWG-ALGDPD 294
Cdd:COG1231  323 AGVLLGYVGGDDARALAALSPEERVAAALEQLARIFGVYAAEPVDYVSTDWGrdpwsrgayaAAPPGQLTAAGpALAEPD 402

                        410       420       430
                 ....*....|....*....|....*....|....*.
gi 489189943 295 LGIYACGDWCS---SGRVEGAWLSGQEAARRLLEHL 327
Cdd:COG1231  403 GRIHFAGEHTSdewPGWVEGALESGERAAAEILARL 438
Amino_oxidase pfam01593
Flavin containing amine oxidoreductase; This family consists of various amine oxidases, ...
 12-324 2.06e-11

Flavin containing amine oxidoreductase; This family consists of various amine oxidases, including maze polyamine oxidase (PAO)and various flavin containing monoamine oxidases (MAO). The aligned region includes the flavin binding site of these enzymes. The family also contains phytoene dehydrogenases and related enzymes. In vertebrates MAO plays an important role regulating the intracellular levels of amines via there oxidation; these include various neurotransmitters, neurotoxins and trace amines. In lower eukaryotes such as aspergillus and in bacteria the main role of amine oxidases is to provide a source of ammonium. PAOs in plants, bacteria and protozoa oxidase spermidine and spermine to an aminobutyral, diaminopropane and hydrogen peroxide and are involved in the catabolism of polyamines. Other members of this family include tryptophan 2-monooxygenase, putrescine oxidase, corticosteroid binding proteins and antibacterial glycoproteins.


Pssm-ID: 396255 [Multi-domain]  Cd Length: 446  Bit Score: 64.43  E-value: 2.06e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489189943   12 IAGLSAAHALRSAGQTVQLFDKGHGSGGRMASKRSEAGTLDLGAQYFT-------------------------------- 59
Cdd:pfam01593   1 LAGLAAARELLRAGHDVTVLEARDRVGGRIRTVRDDGFLIELGAMWFHgaqppllallkelgledrlvlpdpapfytvlf 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489189943   60 --------------------------------ARDRRFLDALQHWREEGW--------------------------VDEW 81
Cdd:pfam01593  81 aggrrypgdfrrvpagwegllefgrllsipekLRLGLAALASDALDEFDLddfslaesllflgrrgpgdvevwdrlIDPE 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489189943   82 KPALYQYRDGQLSPSPDE-----------------QPRWVGIPRMSAITRAL---LTDLQVVFSCRITEV--FRGKQHWH 139
Cdd:pfam01593 161 LFAALPFASGAFAGDPSElsaglalpllwallgegGSLLLPRGGLGALPDALaaqLLGGDVRLNTRVRSIdrEGDGVTVT 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489189943  140 LQDAEgqnHGPFNQVLIAIPAP--QATPLLASVPKLAATAASVV-MEPTWAVALGFREVLdTPVQGCFVHDSPIA----- 211
Cdd:pfam01593 241 LTDGE---VIEADAVIVTVPLGvlKRILFTPPLPPEKARAIRNLgYGPVNKVHLEFDRKF-WPDLGLLGLLSELLtglgt 316

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489189943  212 ---WLACNRSKP-GRDTTLDTWVLHATsqWSRQHIDMAKEDVVEHLRCAFAEVIGCAVPEAAFSIAHRW----------- 276
Cdd:pfam01593 317 afsWLTFPNRAPpGKGLLLLVYVGPGD--RARELEGLSDEELLQAVLRDLRKLFGEEAPEPLRVLVSDWhtdpwprgsys 394

                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|..
gi 489189943  277 LYARPAEAHQWGALG-DPDLGIYACGDWCSS---GRVEGAWLSGQEAARRLL 324
Cdd:pfam01593 395 LPQYGPGHDDYRPLArTPDPGLFFAGEHTSTgypGTVEGAIESGRRAARAVL 446
HemY COG1232
Protoporphyrinogen oxidase HemY/PPOX [Coenzyme transport and metabolism]; Protoporphyrinogen ...
 2-327 1.24e-09

Protoporphyrinogen oxidase HemY/PPOX [Coenzyme transport and metabolism]; Protoporphyrinogen oxidase HemY/PPOX is part of the Pathway/BioSystem: Heme biosynthesis


Pssm-ID: 440845 [Multi-domain]  Cd Length: 443  Bit Score: 59.08  E-value: 1.24e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489189943   2 SVPIAIIGTGIAGLSAAHALRSAGQTVQLFDKGHGSGGRMASKRSEAGTLDLGAQYFTARDRRFLDaLqhWREEGWVDEW 81
Cdd:COG1232    1 MKRVAVIGGGIAGLTAAYRLAKAGHEVTVLEASDRVGGLIRTVEVDGFRIDRGPHSFLTRDPEVLE-L--LRELGLGDEL 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489189943  82 KPAL----YQYRDGQLSPSP--------------------------------DEQP------RWVG-------------- 105
Cdd:COG1232   78 VWPNtrksYIYYGGKLHPLPqgplallrspllslagklrallellaprrppgEDESlaefvrRRFGrevyerlveplleg 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489189943 106 --------------IPR----------------------------------MSAITRALLTDLQ---VVFSCRITEVFRG 134
Cdd:COG1232  158 vyagdpdelsadwaFPRlkrlelehgslikgalalrkgakagevfgylrggLGTLVEALAEALEageIRLGTRVTAIERE 237

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489189943 135 KQHWHLQDAEGQNHgPFNQVLIAIPAPQATPLLASVP-KLAATAASVVMEPTWAVALGFREVLDTPVQGCFV---HDSPI 210
Cdd:COG1232  238 GGGWRVTTSDGETI-EADAVVSATPAPALARLLAPLPpEVAAALAGIPYASVAVVALGFDRPDLPPPDGFGWlvpRDEGV 316

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489189943 211 AWLAC--------NRSKP---------GRDTTLDTWvlhatsqwsrqhiDMAKEDVVEHLRCAFAEVIGCAvPEAAFSIA 273
Cdd:COG1232  317 PILAVtfssnkwpHRAPDgkvllrlevGGAGDPELW-------------QLSDEELVALALADLRKLLGID-AEPVDTRV 382

                        410       420       430       440       450       460
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 489189943 274 HRWLYARP----------AEAHQWGALGDpdlGIYACGDWCSSGRVEGAWLSGQEAARRLLEHL 327
Cdd:COG1232  383 VRWPKAYPqytvghlervAAIREALAALP---GLYLAGRAYDGVGLPDCIRSGREAAERILAEL 443
PRK11883 PRK11883
protoporphyrinogen oxidase; Reviewed
 5-61 2.37e-07

protoporphyrinogen oxidase; Reviewed


Pssm-ID: 237009 [Multi-domain]  Cd Length: 451  Bit Score: 51.77  E-value: 2.37e-07
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 489189943   5 IAIIGTGIAGLSAAHALRSAGQ--TVQLFDKGHGSGGRMASKRSEAGTLDLGAQYFTAR 61
Cdd:PRK11883   3 VAIIGGGITGLSAAYRLHKKGPdaDITLLEASDRLGGKIQTVRKDGFPIELGPESFLAR 61
COG1233 COG1233
Phytoene dehydrogenase-related protein [Secondary metabolites biosynthesis, transport and ...
 1-69 3.27e-06

Phytoene dehydrogenase-related protein [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 440846 [Multi-domain]  Cd Length: 491  Bit Score: 48.31  E-value: 3.27e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 489189943   1 MSVPIAIIGTGIAGLSAAHALRSAGQTVQLFDKGHGSGGRMASKRSEAGTLDLGAQYFTARD--RRFLDAL 69
Cdd:COG1233    2 MMYDVVVIGAGIGGLAAAALLARAGYRVTVLEKNDTPGGRARTFERPGFRFDVGPSVLTMPGvlERLFREL 72
CzcO COG2072
Predicted flavoprotein CzcO associated with the cation diffusion facilitator CzcD [Inorganic ...
 3-39 5.02e-06

Predicted flavoprotein CzcO associated with the cation diffusion facilitator CzcD [Inorganic ion transport and metabolism];


Pssm-ID: 441675 [Multi-domain]  Cd Length: 414  Bit Score: 47.55  E-value: 5.02e-06
                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 489189943   3 VPIAIIGTGIAGLSAAHALRSAGQTVQLFDKGHGSGG 39
Cdd:COG2072    7 VDVVVIGAGQAGLAAAYHLRRAGIDFVVLEKADDVGG 43
COG3349 COG3349
Uncharacterized protein, contains NAD-binding domain and a Fe-S cluster [General function ...
 1-327 9.09e-06

Uncharacterized protein, contains NAD-binding domain and a Fe-S cluster [General function prediction only];


Pssm-ID: 442577 [Multi-domain]  Cd Length: 445  Bit Score: 47.16  E-value: 9.09e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489189943   1 MSVPIAIIGTGIAGLSAAHALRSAGQTVQLFDKGHGSGGR---------------------------------------- 40
Cdd:COG3349    2 MPPRVVVVGGGLAGLAAAVELAEAGFRVTLLEARPRLGGRarsfpdpdtglpidngqhvllgcyrntldllrrigaadnl 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489189943  41 -------MASKRSEAGTLD--------------LGAQYFTARDR----RFLDALQHWREEGWVD----EW------KPAL 85
Cdd:COG3349   82 vgpeplqFPLPGGRRWTLRaprlpaplhllralLRAPGLSLADRlallRLLTACRERRWRELDDisvaDWlrrhgqSPRL 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489189943  86 YQ--------------------------YRDGQLSPSPDEQPRWvgiPRMSaiTRALLTD-----LQ-----VVFSCRIT 129
Cdd:COG3349  162 IRrlweplllaalntppeqasarlaltvLRETLLAGPAASDLLV---PRGP--LSELFVDpalayLEarggeVRLGTRVR 236

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489189943 130 EVFRGKQHWHLQDAEGQNHGPFNQVLIAIPAPQATPLLASVPKLAATAASVVMEPTW--AVALGFREVLDTPVQGCF-VH 206
Cdd:COG3349  237 ALEFDGGRVTGLVLADGETVPADAVVLAVPPEVAARLLPELARLPELGLLAPLEYSPivNVHLWLDRPVTLGPPPFAgLV 316

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489189943 207 DSPIAWLacnRSKPGRDTTLDtWVLHATSQWSRQHIDMAKEDVVEHLRCAFAEVIGC---AVPEAAFSIA-HRWLYA--- 279
Cdd:COG3349  317 GSTSQWV---FDRGAGDGGQG-GVLSVVISAADRLLDLSREELAAEVWAELAALLPAareALPVWSRVVReKRATFAatp 392

                        410       420       430       440       450
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 489189943 280 -----RPAEAHQWGalgdpdlGIYACGDWCSSG---RVEGAWLSGQEAARRLLEHL 327
Cdd:COG3349  393 gsdrlRPGARTPIP-------NLFLAGDWTATGlpaTMEGAVRSGRRAANAILARL 441
Ppro0129 COG2907
Predicted flavin-containing amine oxidase [General function prediction only];
5-39 1.14e-05

Predicted flavin-containing amine oxidase [General function prediction only];


Pssm-ID: 442151 [Multi-domain]  Cd Length: 423  Bit Score: 46.65  E-value: 1.14e-05
                         10        20        30
                 ....*....|....*....|....*....|....*
gi 489189943   5 IAIIGTGIAGLSAAHALRSAgQTVQLFDKGHGSGG 39
Cdd:COG2907    6 IAVIGSGISGLTAAWLLSRR-HDVTLFEANDRLGG 39
DadA COG0665
Glycine/D-amino acid oxidase (deaminating) [Amino acid transport and metabolism];
1-74 1.61e-05

Glycine/D-amino acid oxidase (deaminating) [Amino acid transport and metabolism];


Pssm-ID: 440429 [Multi-domain]  Cd Length: 364  Bit Score: 46.05  E-value: 1.61e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 489189943   1 MSVPIAIIGTGIAGLSAAHALRSAGQTVQLFDKGHGSGGrmASKRSeAGTldLGAQYFTARDRRF----LDALQHWRE 74
Cdd:COG0665    1 ATADVVVIGGGIAGLSTAYHLARRGLDVTVLERGRPGSG--ASGRN-AGQ--LRPGLAALADRALvrlaREALDLWRE 73
PRK07233 PRK07233
hypothetical protein; Provisional
 5-43 3.94e-05

hypothetical protein; Provisional


Pssm-ID: 235977 [Multi-domain]  Cd Length: 434  Bit Score: 44.88  E-value: 3.94e-05
                         10        20        30
                 ....*....|....*....|....*....|....*....
gi 489189943   5 IAIIGTGIAGLSAAHALRSAGQTVQLFDKGHGSGGRMAS 43
Cdd:PRK07233   2 IAIVGGGIAGLAAAYRLAKRGHEVTVFEADDQLGGLAAS 40
PRK11749 PRK11749
dihydropyrimidine dehydrogenase subunit A; Provisional
 5-39 6.43e-05

dihydropyrimidine dehydrogenase subunit A; Provisional


Pssm-ID: 236967 [Multi-domain]  Cd Length: 457  Bit Score: 44.40  E-value: 6.43e-05
                         10        20        30
                 ....*....|....*....|....*....|....*
gi 489189943   5 IAIIGTGIAGLSAAHALRSAGQTVQLFDKGHGSGG 39
Cdd:PRK11749 143 VAVIGAGPAGLTAAHRLARKGYDVTIFEARDKAGG 177
DAO pfam01266
FAD dependent oxidoreductase; This family includes various FAD dependent oxidoreductases: ...
 5-74 8.49e-05

FAD dependent oxidoreductase; This family includes various FAD dependent oxidoreductases: Glycerol-3-phosphate dehydrogenase EC:1.1.99.5, Sarcosine oxidase beta subunit EC:1.5.3.1, D-alanine oxidase EC:1.4.99.1, D-aspartate oxidase EC:1.4.3.1.


Pssm-ID: 426168 [Multi-domain]  Cd Length: 339  Bit Score: 43.93  E-value: 8.49e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 489189943    5 IAIIGTGIAGLSAAHALRSAGQTVQLFDKGHGSGGRmASKRSeAGTldLGAQYFTARDRRF----LDALQHWRE 74
Cdd:pfam01266   2 VVVIGGGIVGLSTAYELARRGLSVTLLERGDDPGSG-ASGRN-AGL--IHPGLRYLEPSELarlaLEALDLWEE 71
GltD COG0493
NADPH-dependent glutamate synthase beta chain or related oxidoreductase [Amino acid transport ...
 5-39 1.49e-04

NADPH-dependent glutamate synthase beta chain or related oxidoreductase [Amino acid transport and metabolism, General function prediction only]; NADPH-dependent glutamate synthase beta chain or related oxidoreductase is part of the Pathway/BioSystem: Glutamine biosynthesis


Pssm-ID: 440259 [Multi-domain]  Cd Length: 434  Bit Score: 43.20  E-value: 1.49e-04
                         10        20        30
                 ....*....|....*....|....*....|....*
gi 489189943   5 IAIIGTGIAGLSAAHALRSAGQTVQLFDKGHGSGG 39
Cdd:COG0493  124 VAVVGSGPAGLAAAYQLARAGHEVTVFEALDKPGG 158
PRK06292 PRK06292
dihydrolipoamide dehydrogenase; Validated
 1-44 2.46e-04

dihydrolipoamide dehydrogenase; Validated


Pssm-ID: 235774 [Multi-domain]  Cd Length: 460  Bit Score: 42.47  E-value: 2.46e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*....
gi 489189943   1 MSVPIAIIGTGIAGLSAAHALRSAGQTVQLFDKGHGSG-----GRMASK 44
Cdd:PRK06292   2 EKYDVIVIGAGPAGYVAARRAAKLGKKVALIEKGPLGGtclnvGCIPSK 50
PRK06753 PRK06753
hypothetical protein; Provisional
 5-35 2.51e-04

hypothetical protein; Provisional


Pssm-ID: 168661 [Multi-domain]  Cd Length: 373  Bit Score: 42.37  E-value: 2.51e-04
                         10        20        30
                 ....*....|....*....|....*....|.
gi 489189943   5 IAIIGTGIAGLSAAHALRSAGQTVQLFDKGH 35
Cdd:PRK06753   3 IAIIGAGIGGLTAAALLQEQGHEVKVFEKNE 33
UbiH COG0654
2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme ...
 1-146 2.70e-04

2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme transport and metabolism, Energy production and conversion]; 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases is part of the Pathway/BioSystem: Ubiquinone biosynthesis


Pssm-ID: 440419 [Multi-domain]  Cd Length: 326  Bit Score: 42.23  E-value: 2.70e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489189943   1 MSVPIAIIGTGIAGLSAAHALRSAGQTVQLFDK--GHGSGGRmaskrseAGTLDLGAQYFTAR---DRRFLDALQHWREE 75
Cdd:COG0654    2 MRTDVLIVGGGPAGLALALALARAGIRVTVVERapPPRPDGR-------GIALSPRSLELLRRlglWDRLLARGAPIRGI 74

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 489189943  76 GWVDEWKPAlyqyRDGQLSPSPDEQPRWVGIPRmSAITRALLTDLQ-----VVFSCRITEVFRGKQHWHLQDAEGQ 146
Cdd:COG0654   75 RVRDGSDGR----VLARFDAAETGLPAGLVVPR-ADLERALLEAARalgveLRFGTEVTGLEQDADGVTVTLADGR 145
PRK12770 PRK12770
putative glutamate synthase subunit beta; Provisional
 5-81 2.78e-04

putative glutamate synthase subunit beta; Provisional


Pssm-ID: 237197 [Multi-domain]  Cd Length: 352  Bit Score: 42.28  E-value: 2.78e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489189943   5 IAIIGTGIAGLSAAHALRSAGQTVQLFDKGHGSGGRMA---------SKRSEAGTLDL---GAQYFTaRDRRFLDALQHw 72
Cdd:PRK12770  21 VAIIGAGPAGLAAAGYLACLGYEVHVYDKLPEPGGLMLfgipefripIERVREGVKELeeaGVVFHT-RTKVCCGEPLH- 98


                 ....*....
gi 489189943  73 REEGwvDEW 81
Cdd:PRK12770  99 EEEG--DEF 105
PRK12814 PRK12814
putative NADPH-dependent glutamate synthase small subunit; Provisional
 5-41 2.81e-04

putative NADPH-dependent glutamate synthase small subunit; Provisional


Pssm-ID: 139246 [Multi-domain]  Cd Length: 652  Bit Score: 42.41  E-value: 2.81e-04
                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 489189943   5 IAIIGTGIAGLSAAHALRSAGQTVQLFDKGHGSGGRM 41
Cdd:PRK12814 196 VAIIGAGPAGLTAAYYLLRKGHDVTIFDANEQAGGMM 232
gltD PRK12810
glutamate synthase subunit beta; Reviewed
 5-39 3.33e-04

glutamate synthase subunit beta; Reviewed


Pssm-ID: 237213 [Multi-domain]  Cd Length: 471  Bit Score: 42.07  E-value: 3.33e-04
                         10        20        30
                 ....*....|....*....|....*....|....*
gi 489189943   5 IAIIGTGIAGLSAAHALRSAGQTVQLFDKGHGSGG 39
Cdd:PRK12810 146 VAVVGSGPAGLAAADQLARAGHKVTVFERADRIGG 180
FAD_binding_2 pfam00890
FAD binding domain; This family includes members that bind FAD. This family includes the ...
 5-39 4.58e-04

FAD binding domain; This family includes members that bind FAD. This family includes the flavoprotein subunits from succinate and fumarate dehydrogenase, aspartate oxidase and the alpha subunit of adenylylsulphate reductase.


Pssm-ID: 395718 [Multi-domain]  Cd Length: 398  Bit Score: 41.50  E-value: 4.58e-04
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 489189943    5 IAIIGTGIAGLSAAHALRSAGQTVQLFDKGHGSGG 39
Cdd:pfam00890   2 VLVIGGGLAGLAAALAAAEAGLKVAVVEKGQPFGG 36
PRK12771 PRK12771
putative glutamate synthase (NADPH) small subunit; Provisional
 5-41 7.24e-04

putative glutamate synthase (NADPH) small subunit; Provisional


Pssm-ID: 237198 [Multi-domain]  Cd Length: 564  Bit Score: 41.01  E-value: 7.24e-04
                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 489189943   5 IAIIGTGIAGLSAAHALRSAGQTVQLFDKGHGSGGRM 41
Cdd:PRK12771 140 VAVIGGGPAGLSAAYHLRRMGHAVTIFEAGPKLGGMM 176
PLN02576 PLN02576
protoporphyrinogen oxidase
 6-97 7.63e-04

protoporphyrinogen oxidase


Pssm-ID: 215314 [Multi-domain]  Cd Length: 496  Bit Score: 41.15  E-value: 7.63e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489189943   6 AIIGTGIAGLSAAHALRSA-GQTVQLFDKGHGSGGRMASKRSEAGTLDLGAQYFTARD---RRFLDAlqHWREE-GWVDE 80
Cdd:PLN02576  16 AVVGAGVSGLAAAYALASKhGVNVLVTEARDRVGGNITSVSEDGFIWEEGPNSFQPSDpelTSAVDS--GLRDDlVFPDP 93

                         90
                 ....*....|....*..
gi 489189943  81 WKPAlYQYRDGQLSPSP 97
Cdd:PLN02576  94 QAPR-YVVWNGKLRPLP 109
PLN02268 PLN02268
probable polyamine oxidase
 7-55 9.36e-04

probable polyamine oxidase


Pssm-ID: 177909 [Multi-domain]  Cd Length: 435  Bit Score: 40.83  E-value: 9.36e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*....
gi 489189943   7 IIGTGIAGLSAAHALRSAGQTVQLFDKGHGSGGRMASKRSEAGTLDLGA 55
Cdd:PLN02268   5 VIGGGIAGIAAARALHDASFKVTLLESRDRIGGRVHTDYSFGFPVDMGA 53
Pyr_redox_2 pfam07992
Pyridine nucleotide-disulphide oxidoreductase; This family includes both class I and class II ...
 5-34 1.15e-03

Pyridine nucleotide-disulphide oxidoreductase; This family includes both class I and class II oxidoreductases and also NADH oxidases and peroxidases. This domain is actually a small NADH binding domain within a larger FAD binding domain.


Pssm-ID: 400379 [Multi-domain]  Cd Length: 301  Bit Score: 39.99  E-value: 1.15e-03
                          10        20        30
                  ....*....|....*....|....*....|
gi 489189943    5 IAIIGTGIAGLSAAHALRSAGQTVQLFDKG 34
Cdd:pfam07992   3 VVVIGGGPAGLAAALTLAQLGGKVTLIEDE 32
PLN03000 PLN03000
amine oxidase
 5-59 2.06e-03

amine oxidase


Pssm-ID: 178578 [Multi-domain]  Cd Length: 881  Bit Score: 40.00  E-value: 2.06e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 489189943   5 IAIIGTGIAGLSAAHALRSAGQTVQLFDKGHGSGGRMASKRSEAGTL----DLGAQYFT 59
Cdd:PLN03000 187 VVIVGAGLSGLAAARQLMRFGFKVTVLEGRKRPGGRVYTKKMEANRVgaaaDLGGSVLT 245
TrxB COG0492
Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones];
5-42 4.60e-03

Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440258 [Multi-domain]  Cd Length: 305  Bit Score: 38.18  E-value: 4.60e-03
                         10        20        30
                 ....*....|....*....|....*....|....*...
gi 489189943   5 IAIIGTGIAGLSAAHALRSAGQTVQLFDKGHgSGGRMA 42
Cdd:COG0492    3 VVIIGAGPAGLTAAIYAARAGLKTLVIEGGE-PGGQLA 39
SdhA COG1053
Succinate dehydrogenase/fumarate reductase, flavoprotein subunit [Energy production and ...
 7-49 6.68e-03

Succinate dehydrogenase/fumarate reductase, flavoprotein subunit [Energy production and conversion]; Succinate dehydrogenase/fumarate reductase, flavoprotein subunit is part of the Pathway/BioSystem: TCA cycle


Pssm-ID: 440673 [Multi-domain]  Cd Length: 443  Bit Score: 37.89  E-value: 6.68e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|...
gi 489189943   7 IIGTGIAGLSAAHALRSAGQTVQLFDKGHGSGGrmASKRSEAG 49
Cdd:COG1053    8 VVGSGGAGLRAALEAAEAGLKVLVLEKVPPRGG--HTAAAQGG 48
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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