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Conserved domains on  [gi|489189082|ref|WP_003098467|]
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MULTISPECIES: 3-hydroxyacyl-CoA dehydrogenase [Pseudomonas]

Protein Classification

3-hydroxyacyl-CoA dehydrogenase( domain architecture ID 11483206)

3-hydroxyacyl-CoA dehydrogenase (HCDH) catalyzes the NAD-dependent oxidation of 3-hydroxyacyl-CoA to form 3-oxoacyl-CoA

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PRK08268 PRK08268
3-hydroxy-acyl-CoA dehydrogenase; Validated
 1-506 0e+00

3-hydroxy-acyl-CoA dehydrogenase; Validated


:

Pssm-ID: 236211 [Multi-domain]  Cd Length: 507  Bit Score: 768.24  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489189082   1 MSEPSIVLIGIVGTGAMGQGIAQLAACAGLSVLLYDSRQGVALQAREQIATVLARQVERGRLEAEAVERAMGNLRVVEDL 80
Cdd:PRK08268   2 MALPSIATVAVIGAGAMGAGIAQVAAQAGHTVLLYDARAGAAAAARDGIAARLAKLVEKGKLTAEQADAALARLRPVEAL 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489189082  81 RVLGGCQLVIEAIVENLEAKQALFRQLEEVVGDEAILASNTSSLSVTAIASACRDPGRVAGLHFFNPVPLMRLVEVIEGL 160
Cdd:PRK08268  82 ADLADCDLVVEAIVERLDVKQALFAQLEAIVSPDCILATNTSSLSITAIAAALKHPERVAGLHFFNPVPLMKLVEVVSGL 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489189082 161 ATRTGIAERLCALVATFGHQAVRATDSPGFIVNHAGRAFGTEALRILGEGVAPVAAIDEVLREGAGFRMGPFELFDLVGL 240
Cdd:PRK08268 162 ATDPAVADALYALARAWGKTPVRAKDTPGFIVNRAARPYYTEALRVLEEGVADPATIDAILREAAGFRMGPFELMDLIGL 241

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489189082 241 DVSLPVMESIYRQYYEEPRYRPHPLLRQMLAAGRLGRKSGQGFYRY-DGAGQvpvAAPAVAPGAALPPVWLGVDDEHDRA 319
Cdd:PRK08268 242 DVNHAVMESVYRQFYQEPRFRPSLIQQELVAAGRLGRKSGQGFYRYaDGAKQ---PPAEAAPPAALPPVWVSADVEGDLA 318

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489189082 320 PLLMLLQRLGAEVESGERPSGAALCLLAPLGADVSAAARRFAVDPTRSLAIDVLSDLE--RHRCLMACPATRAELQQAAR 397
Cdd:PRK08268 319 ALARLLERLGATIETGEGPSADGLVLLAPTGGDTTTAAAREGLDAARVVLIDLLLDYAaaKRRTLMAAPATSPAARDAAH 398

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489189082 398 TLFARDGVGVTLIRDSAGFIVQRTLASIVNLACDIAQQGIASVEHIDLAVRLGLGYPLGPLEWGDRLGAGRVLRILERLH 477
Cdd:PRK08268 399 ALFQQDGKAVSVIRDSPGFVAQRTVAMIVNEAADIAQQGIASPADIDLAMRLGLNYPLGPLAWGDRLGAARILRVLENLQ 478

                        490       500
                 ....*....|....*....|....*....
gi 489189082 478 ALSGDPRYRPSPWLRRRAQLGLSLRQPDS 506
Cdd:PRK08268 479 ALYGDPRYRPSPWLRRRAALGLSLRSEEA 507
 
Name Accession Description Interval E-value
PRK08268 PRK08268
3-hydroxy-acyl-CoA dehydrogenase; Validated
 1-506 0e+00

3-hydroxy-acyl-CoA dehydrogenase; Validated


Pssm-ID: 236211 [Multi-domain]  Cd Length: 507  Bit Score: 768.24  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489189082   1 MSEPSIVLIGIVGTGAMGQGIAQLAACAGLSVLLYDSRQGVALQAREQIATVLARQVERGRLEAEAVERAMGNLRVVEDL 80
Cdd:PRK08268   2 MALPSIATVAVIGAGAMGAGIAQVAAQAGHTVLLYDARAGAAAAARDGIAARLAKLVEKGKLTAEQADAALARLRPVEAL 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489189082  81 RVLGGCQLVIEAIVENLEAKQALFRQLEEVVGDEAILASNTSSLSVTAIASACRDPGRVAGLHFFNPVPLMRLVEVIEGL 160
Cdd:PRK08268  82 ADLADCDLVVEAIVERLDVKQALFAQLEAIVSPDCILATNTSSLSITAIAAALKHPERVAGLHFFNPVPLMKLVEVVSGL 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489189082 161 ATRTGIAERLCALVATFGHQAVRATDSPGFIVNHAGRAFGTEALRILGEGVAPVAAIDEVLREGAGFRMGPFELFDLVGL 240
Cdd:PRK08268 162 ATDPAVADALYALARAWGKTPVRAKDTPGFIVNRAARPYYTEALRVLEEGVADPATIDAILREAAGFRMGPFELMDLIGL 241

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489189082 241 DVSLPVMESIYRQYYEEPRYRPHPLLRQMLAAGRLGRKSGQGFYRY-DGAGQvpvAAPAVAPGAALPPVWLGVDDEHDRA 319
Cdd:PRK08268 242 DVNHAVMESVYRQFYQEPRFRPSLIQQELVAAGRLGRKSGQGFYRYaDGAKQ---PPAEAAPPAALPPVWVSADVEGDLA 318

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489189082 320 PLLMLLQRLGAEVESGERPSGAALCLLAPLGADVSAAARRFAVDPTRSLAIDVLSDLE--RHRCLMACPATRAELQQAAR 397
Cdd:PRK08268 319 ALARLLERLGATIETGEGPSADGLVLLAPTGGDTTTAAAREGLDAARVVLIDLLLDYAaaKRRTLMAAPATSPAARDAAH 398

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489189082 398 TLFARDGVGVTLIRDSAGFIVQRTLASIVNLACDIAQQGIASVEHIDLAVRLGLGYPLGPLEWGDRLGAGRVLRILERLH 477
Cdd:PRK08268 399 ALFQQDGKAVSVIRDSPGFVAQRTVAMIVNEAADIAQQGIASPADIDLAMRLGLNYPLGPLAWGDRLGAARILRVLENLQ 478

                        490       500
                 ....*....|....*....|....*....
gi 489189082 478 ALSGDPRYRPSPWLRRRAQLGLSLRQPDS 506
Cdd:PRK08268 479 ALYGDPRYRPSPWLRRRAALGLSLRSEEA 507
FadB COG1250
3-hydroxyacyl-CoA dehydrogenase [Lipid transport and metabolism]; 3-hydroxyacyl-CoA ...
 9-286 1.16e-130

3-hydroxyacyl-CoA dehydrogenase [Lipid transport and metabolism]; 3-hydroxyacyl-CoA dehydrogenase is part of the Pathway/BioSystem: Fatty acid biosynthesis


Pssm-ID: 440862 [Multi-domain]  Cd Length: 281  Bit Score: 380.61  E-value: 1.16e-130
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489189082   9 IGIVGTGAMGQGIAQLAACAGLSVLLYDSRQGVALQAREQIATVLARQVERGRLEAEAVERAMGNLRVVEDLRVLGGCQL 88
Cdd:COG1250    5 VAVIGAGTMGAGIAAVFANAGYEVVLLDISPEALERARARIAKLLDKLVKKGKLTEEEADAALARITPTTDLAALADADL 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489189082  89 VIEAIVENLEAKQALFRQLEEVVGDEAILASNTSSLSVTAIASACRDPGRVAGLHFFNPVPLMRLVEVIEGLATRTGIAE 168
Cdd:COG1250   85 VIEAVPEDLDLKQEVFAELDAVAPPDAILASNTSSLSITELAAATKRPERFIGLHFFNPVPLMPLVEVIRGPATSDETVA 164

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489189082 169 RLCALVATFGHQAVRATDSPGFIVNHAGRAFGTEALRILGEGVAPVAAIDEVLREGAGFRMGPFELFDLVGLDVSLPVME 248
Cdd:COG1250  165 TAVAFARRLGKTPVVVKDTPGFIVNRILVPYLNEAIRLLEEGVASPEDIDAAMRLGFGFPMGPFELADLVGLDTALAVLE 244

                        250       260       270
                 ....*....|....*....|....*....|....*...
gi 489189082 249 SIYRQyYEEPRYRPHPLLRQMLAAGRLGRKSGQGFYRY 286
Cdd:COG1250  245 VLYEA-LGDPRYRPPPLLKKLVEAGRLGRKTGRGFYDY 281
3HCDH_N pfam02737
3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; This family also includes lambda ...
 9-187 5.91e-68

3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; This family also includes lambda crystallin.


Pssm-ID: 397037 [Multi-domain]  Cd Length: 180  Bit Score: 216.25  E-value: 5.91e-68
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489189082    9 IGIVGTGAMGQGIAQLAACAGLSVLLYDSRQGVALQAREQIATVLARQVERGRLEAEAVERAMGNLRVVEDLRVLGGCQL 88
Cdd:pfam02737   2 VAVIGAGTMGAGIAQVFALAGLEVVLVDISEEALEKALERIESSLERLVEKGRITEEEVDAALARISFTTDLAAAVDADL 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489189082   89 VIEAIVENLEAKQALFRQLEEVVGDEAILASNTSSLSVTAIASACRDPGRVAGLHFFNPVPLMRLVEVIEGLATRTGIAE 168
Cdd:pfam02737  82 VIEAVPENLELKRKLFAELDAIAPPDAILATNTSSLSITELAAATKRPERFIGLHFFNPPPLMPLVEVVRGEKTSPETVA 161

                         170
                  ....*....|....*....
gi 489189082  169 RLCALVATFGHQAVRATDS 187
Cdd:pfam02737 162 TTVELAKKIGKTPVVVKDT 180
fa_ox_alpha_mit TIGR02441
fatty acid oxidation complex, alpha subunit, mitochondrial; Members represent alpha subunit of ...
 9-288 8.08e-46

fatty acid oxidation complex, alpha subunit, mitochondrial; Members represent alpha subunit of mitochondrial multifunctional fatty acid degradation enzyme complex. Subunit activities include: enoyl-CoA hydratase (EC 4.2.1.17) _ 3-hydroxyacyl-CoA dehydrogenase (EC 1.1.1.35). Some characterization in human (SP:P40939), pig (SP:Q29554), and rat (SP:Q64428). The beta subunit has activity: acetyl-CoA C-acyltransferase (EC 2.3.1.16).


Pssm-ID: 131494 [Multi-domain]  Cd Length: 737  Bit Score: 170.79  E-value: 8.08e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489189082    9 IGIVGTGAMGQGIAQLAACAGLSVLLYDSRQGVALQAREQIATVLARQVERGRLEAEAVERAMGNLRVVEDLRVLGGCQL 88
Cdd:TIGR02441 338 LAVLGAGLMGAGIAQVSVDKGLKTVLKDATPAGLDRGQQQVFKGLNKKVKRKKITSLERDSILSNLTPTLDYSGFKNADM 417

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489189082   89 VIEAIVENLEAKQALFRQLEEVVGDEAILASNTSSLSVTAIASACRDPGRVAGLHFFNPVPLMRLVEVIEGLATRTGIAE 168
Cdd:TIGR02441 418 VIEAVFEDLSLKHKVIKEVEAVVPPHCIIASNTSALPIKDIAAVSSRPEKVIGMHYFSPVDKMQLLEIITHDGTSKDTLA 497

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489189082  169 RLCALVATFGHQAVRATDSPGFIVNHAGRAFGTEALRILGEGVAPvAAIDEvLREGAGFRMGPFELFDLVGLDVSLPVME 248
Cdd:TIGR02441 498 SAVAVGLKQGKVVIVVKDGPGFYTTRCLGPMLAEVIRLLQEGVDP-KKLDK-LTTKFGFPVGAATLADEVGVDVAEHVAE 575

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|
gi 489189082  249 SIYRQYYEEPRYRPHPLLRQMLAAGRLGRKSGQGFYRYDG 288
Cdd:TIGR02441 576 DLGKAFGERFGGGSAELLSELVKAGFLGRKSGKGIFIYQE 615
 
Name Accession Description Interval E-value
PRK08268 PRK08268
3-hydroxy-acyl-CoA dehydrogenase; Validated
 1-506 0e+00

3-hydroxy-acyl-CoA dehydrogenase; Validated


Pssm-ID: 236211 [Multi-domain]  Cd Length: 507  Bit Score: 768.24  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489189082   1 MSEPSIVLIGIVGTGAMGQGIAQLAACAGLSVLLYDSRQGVALQAREQIATVLARQVERGRLEAEAVERAMGNLRVVEDL 80
Cdd:PRK08268   2 MALPSIATVAVIGAGAMGAGIAQVAAQAGHTVLLYDARAGAAAAARDGIAARLAKLVEKGKLTAEQADAALARLRPVEAL 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489189082  81 RVLGGCQLVIEAIVENLEAKQALFRQLEEVVGDEAILASNTSSLSVTAIASACRDPGRVAGLHFFNPVPLMRLVEVIEGL 160
Cdd:PRK08268  82 ADLADCDLVVEAIVERLDVKQALFAQLEAIVSPDCILATNTSSLSITAIAAALKHPERVAGLHFFNPVPLMKLVEVVSGL 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489189082 161 ATRTGIAERLCALVATFGHQAVRATDSPGFIVNHAGRAFGTEALRILGEGVAPVAAIDEVLREGAGFRMGPFELFDLVGL 240
Cdd:PRK08268 162 ATDPAVADALYALARAWGKTPVRAKDTPGFIVNRAARPYYTEALRVLEEGVADPATIDAILREAAGFRMGPFELMDLIGL 241

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489189082 241 DVSLPVMESIYRQYYEEPRYRPHPLLRQMLAAGRLGRKSGQGFYRY-DGAGQvpvAAPAVAPGAALPPVWLGVDDEHDRA 319
Cdd:PRK08268 242 DVNHAVMESVYRQFYQEPRFRPSLIQQELVAAGRLGRKSGQGFYRYaDGAKQ---PPAEAAPPAALPPVWVSADVEGDLA 318

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489189082 320 PLLMLLQRLGAEVESGERPSGAALCLLAPLGADVSAAARRFAVDPTRSLAIDVLSDLE--RHRCLMACPATRAELQQAAR 397
Cdd:PRK08268 319 ALARLLERLGATIETGEGPSADGLVLLAPTGGDTTTAAAREGLDAARVVLIDLLLDYAaaKRRTLMAAPATSPAARDAAH 398

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489189082 398 TLFARDGVGVTLIRDSAGFIVQRTLASIVNLACDIAQQGIASVEHIDLAVRLGLGYPLGPLEWGDRLGAGRVLRILERLH 477
Cdd:PRK08268 399 ALFQQDGKAVSVIRDSPGFVAQRTVAMIVNEAADIAQQGIASPADIDLAMRLGLNYPLGPLAWGDRLGAARILRVLENLQ 478

                        490       500
                 ....*....|....*....|....*....
gi 489189082 478 ALSGDPRYRPSPWLRRRAQLGLSLRQPDS 506
Cdd:PRK08268 479 ALYGDPRYRPSPWLRRRAALGLSLRSEEA 507
FadB COG1250
3-hydroxyacyl-CoA dehydrogenase [Lipid transport and metabolism]; 3-hydroxyacyl-CoA ...
 9-286 1.16e-130

3-hydroxyacyl-CoA dehydrogenase [Lipid transport and metabolism]; 3-hydroxyacyl-CoA dehydrogenase is part of the Pathway/BioSystem: Fatty acid biosynthesis


Pssm-ID: 440862 [Multi-domain]  Cd Length: 281  Bit Score: 380.61  E-value: 1.16e-130
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489189082   9 IGIVGTGAMGQGIAQLAACAGLSVLLYDSRQGVALQAREQIATVLARQVERGRLEAEAVERAMGNLRVVEDLRVLGGCQL 88
Cdd:COG1250    5 VAVIGAGTMGAGIAAVFANAGYEVVLLDISPEALERARARIAKLLDKLVKKGKLTEEEADAALARITPTTDLAALADADL 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489189082  89 VIEAIVENLEAKQALFRQLEEVVGDEAILASNTSSLSVTAIASACRDPGRVAGLHFFNPVPLMRLVEVIEGLATRTGIAE 168
Cdd:COG1250   85 VIEAVPEDLDLKQEVFAELDAVAPPDAILASNTSSLSITELAAATKRPERFIGLHFFNPVPLMPLVEVIRGPATSDETVA 164

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489189082 169 RLCALVATFGHQAVRATDSPGFIVNHAGRAFGTEALRILGEGVAPVAAIDEVLREGAGFRMGPFELFDLVGLDVSLPVME 248
Cdd:COG1250  165 TAVAFARRLGKTPVVVKDTPGFIVNRILVPYLNEAIRLLEEGVASPEDIDAAMRLGFGFPMGPFELADLVGLDTALAVLE 244

                        250       260       270
                 ....*....|....*....|....*....|....*...
gi 489189082 249 SIYRQyYEEPRYRPHPLLRQMLAAGRLGRKSGQGFYRY 286
Cdd:COG1250  245 VLYEA-LGDPRYRPPPLLKKLVEAGRLGRKTGRGFYDY 281
PRK05808 PRK05808
3-hydroxybutyryl-CoA dehydrogenase; Validated
 5-286 7.59e-98

3-hydroxybutyryl-CoA dehydrogenase; Validated


Pssm-ID: 180269 [Multi-domain]  Cd Length: 282  Bit Score: 296.87  E-value: 7.59e-98
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489189082   5 SIVLIGIVGTGAMGQGIAQLAACAGLSVLLYDSRQGVALQAREQIATVLARQVERGRLEAEAVERAMGNLRVVEDLRVLG 84
Cdd:PRK05808   2 GIQKIGVIGAGTMGNGIAQVCAVAGYDVVMVDISDAAVDRGLATITKSLDRLVKKGKMTEADKEAALARITGTTDLDDLK 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489189082  85 GCQLVIEAIVENLEAKQALFRQLEEVVGDEAILASNTSSLSVTAIASACRDPGRVAGLHFFNPVPLMRLVEVIEGLATRT 164
Cdd:PRK05808  82 DADLVIEAATENMDLKKKIFAQLDEIAKPEAILATNTSSLSITELAAATKRPDKVIGMHFFNPVPVMKLVEIIRGLATSD 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489189082 165 GIAERLCALVATFGHQAVRATDSPGFIVNHAGRAFGTEALRILGEGVAPVAAIDEVLREGAGFRMGPFELFDLVGLDVSL 244
Cdd:PRK05808 162 ATHEAVEALAKKIGKTPVEVKNAPGFVVNRILIPMINEAIFVLAEGVATAEDIDEGMKLGCNHPIGPLALADLIGLDTCL 241

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|..
gi 489189082 245 PVMESIYRQyYEEPRYRPHPLLRQMLAAGRLGRKSGQGFYRY 286
Cdd:PRK05808 242 AIMEVLYEG-FGDSKYRPCPLLRKMVAAGWLGRKTGRGFYDY 282
PLN02545 PLN02545
3-hydroxybutyryl-CoA dehydrogenase
 5-291 2.60e-89

3-hydroxybutyryl-CoA dehydrogenase


Pssm-ID: 215300 [Multi-domain]  Cd Length: 295  Bit Score: 275.46  E-value: 2.60e-89
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489189082   5 SIVLIGIVGTGAMGQGIAQLAACAGLSVLLYDSRQGVALQAREQIATVLARQVERGRLEAEAVERAMGNLRVVEDLRVLG 84
Cdd:PLN02545   3 EIKKVGVVGAGQMGSGIAQLAAAAGMDVWLLDSDPAALSRGLDSISSSLARLVKKGKMSQEEADATLGRIRCTTNLEELR 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489189082  85 GCQLVIEAIVENLEAKQALFRQLEEVVGDEAILASNTSSLSVTAIASACRDPGRVAGLHFFNPVPLMRLVEVIEGLATRT 164
Cdd:PLN02545  83 DADFIIEAIVESEDLKKKLFSELDRICKPSAILASNTSSISITRLASATQRPQQVIGMHFMNPPPIMKLVEIIRGADTSD 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489189082 165 GIAERLCALVATFGHQAVRATDSPGFIVNHAGRAFGTEALRILGEGVAPVAAIDEVLREGAGFRMGPFELFDLVGLDVSL 244
Cdd:PLN02545 163 EVFDATKALAERFGKTVVCSQDYPGFIVNRILMPMINEAFYALYTGVASKEDIDTGMKLGTNHPMGPLHLADFIGLDTCL 242

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*..
gi 489189082 245 PVMESIYRQyYEEPRYRPHPLLRQMLAAGRLGRKSGQGFYRYDGAGQ 291
Cdd:PLN02545 243 SIMKVLHEG-LGDSKYRPCPLLVQYVDAGRLGRKSGRGVYHYDGKKR 288
PRK07530 PRK07530
3-hydroxybutyryl-CoA dehydrogenase; Validated
 9-288 4.60e-89

3-hydroxybutyryl-CoA dehydrogenase; Validated


Pssm-ID: 181018 [Multi-domain]  Cd Length: 292  Bit Score: 274.58  E-value: 4.60e-89
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489189082   9 IGIVGTGAMGQGIAQLAACAGLSVLLYDSRQGVALQAREQIATVLARQVERGRLEAEAVERAMGNLRVVEDLRVLGGCQL 88
Cdd:PRK07530   7 VGVIGAGQMGNGIAHVCALAGYDVLLNDVSADRLEAGLATINGNLARQVAKGKISEEARAAALARISTATDLEDLADCDL 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489189082  89 VIEAIVENLEAKQALFRQLEEVVGDEAILASNTSSLSVTAIASACRDPGRVAGLHFFNPVPLMRLVEVIEGLATRTGIAE 168
Cdd:PRK07530  87 VIEAATEDETVKRKIFAQLCPVLKPEAILATNTSSISITRLASATDRPERFIGIHFMNPVPVMKLVELIRGIATDEATFE 166

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489189082 169 RLCALVATFGHQAVRATDSPGFIVNHAGRAFGTEALRILGEGVAPVAAIDEVLREGAGFRMGPFELFDLVGLDVSLPVME 248
Cdd:PRK07530 167 AAKEFVTKLGKTITVAEDFPAFIVNRILLPMINEAIYTLYEGVGSVEAIDTAMKLGANHPMGPLELADFIGLDTCLSIMQ 246

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|
gi 489189082 249 SIYrQYYEEPRYRPHPLLRQMLAAGRLGRKSGQGFYRYDG 288
Cdd:PRK07530 247 VLH-DGLADSKYRPCPLLVKYVEAGWLGRKTGRGFYDYRG 285
PRK07819 PRK07819
3-hydroxybutyryl-CoA dehydrogenase; Validated
 5-286 1.40e-87

3-hydroxybutyryl-CoA dehydrogenase; Validated


Pssm-ID: 181133 [Multi-domain]  Cd Length: 286  Bit Score: 270.70  E-value: 1.40e-87
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489189082   5 SIVLIGIVGTGAMGQGIAQLAACAGLSVLLYDSRQGVALQAREQIATVLARQVERGRLEAEAVERAMGNLRVVEDLRVLG 84
Cdd:PRK07819   4 AIQRVGVVGAGQMGAGIAEVCARAGVDVLVFETTEELATAGRNRIEKSLERAVSRGKLTERERDAALARLRFTTDLGDFA 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489189082  85 GCQLVIEAIVENLEAKQALFRQLEEVVGD-EAILASNTSSLSVTAIASACRDPGRVAGLHFFNPVPLMRLVEVIEGLATR 163
Cdd:PRK07819  84 DRQLVIEAVVEDEAVKTEIFAELDKVVTDpDAVLASNTSSIPIMKLAAATKRPGRVLGLHFFNPVPVLPLVELVPTLVTS 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489189082 164 TGIAERLCALV-ATFGHQAVRATDSPGFIVNHAGRAFGTEALRILGEGVAPVAAIDEVLREGAGFRMGPFELFDLVGLDV 242
Cdd:PRK07819 164 EATVARAEEFAsDVLGKQVVRAQDRSGFVVNALLVPYLLSAIRMVESGFATAEDIDKAMVLGCAHPMGPLRLSDLVGLDT 243

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....
gi 489189082 243 SLPVMESIYRQyYEEPRYRPHPLLRQMLAAGRLGRKSGQGFYRY 286
Cdd:PRK07819 244 VKAIADSMYEE-FKEPLYAPPPLLLRMVEAGLLGKKSGRGFYTY 286
PRK09260 PRK09260
3-hydroxyacyl-CoA dehydrogenase;
9-291 2.15e-80

3-hydroxyacyl-CoA dehydrogenase;


Pssm-ID: 236434 [Multi-domain]  Cd Length: 288  Bit Score: 252.40  E-value: 2.15e-80
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489189082   9 IGIVGTGAMGQGIAQLAACAGLSVLLYDSRQGVALQAREQIATVLARQVERGRLEAEAVERAMGNLRVVEDLR-VLGGCQ 87
Cdd:PRK09260   4 LVVVGAGVMGRGIAYVFAVSGFQTTLVDIKQEQLESAQQEIASIFEQGVARGKLTEAARQAALARLSYSLDLKaAVADAD 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489189082  88 LVIEAIVENLEAKQALFRQLEEVVGDEAILASNTSSLSVTAIASACRDPGRVAGLHFFNPVPLMRLVEVIEGLATRTGIA 167
Cdd:PRK09260  84 LVIEAVPEKLELKKAVFETADAHAPAECYIATNTSTMSPTEIASFTKRPERVIAMHFFNPVHKMKLVELIRGLETSDETV 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489189082 168 ERLCALVATFGHQAVRATDSPGFIVNHAGRAFGTEALRILGEGVAPVAAIDEVLREGAGFRMGPFELFDLVGLDVSLPVM 247
Cdd:PRK09260 164 QVAKEVAEQMGKETVVVNEFPGFVTSRISALVGNEAFYMLQEGVATAEDIDKAIRLGLNFPMGPLELGDLVGLDTRLNNL 243

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....
gi 489189082 248 ESIYRQYYEepRYRPHPLLRQMLAAGRLGRKSGQGFYRYDGAGQ 291
Cdd:PRK09260 244 KYLHETLGE--KYRPAPLLEKYVKAGRLGRKTGRGVYDYTNREN 285
3HCDH_N pfam02737
3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; This family also includes lambda ...
 9-187 5.91e-68

3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; This family also includes lambda crystallin.


Pssm-ID: 397037 [Multi-domain]  Cd Length: 180  Bit Score: 216.25  E-value: 5.91e-68
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489189082    9 IGIVGTGAMGQGIAQLAACAGLSVLLYDSRQGVALQAREQIATVLARQVERGRLEAEAVERAMGNLRVVEDLRVLGGCQL 88
Cdd:pfam02737   2 VAVIGAGTMGAGIAQVFALAGLEVVLVDISEEALEKALERIESSLERLVEKGRITEEEVDAALARISFTTDLAAAVDADL 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489189082   89 VIEAIVENLEAKQALFRQLEEVVGDEAILASNTSSLSVTAIASACRDPGRVAGLHFFNPVPLMRLVEVIEGLATRTGIAE 168
Cdd:pfam02737  82 VIEAVPENLELKRKLFAELDAIAPPDAILATNTSSLSITELAAATKRPERFIGLHFFNPPPLMPLVEVVRGEKTSPETVA 161

                         170
                  ....*....|....*....
gi 489189082  169 RLCALVATFGHQAVRATDS 187
Cdd:pfam02737 162 TTVELAKKIGKTPVVVKDT 180
PRK06130 PRK06130
3-hydroxybutyryl-CoA dehydrogenase; Validated
 9-288 1.34e-58

3-hydroxybutyryl-CoA dehydrogenase; Validated


Pssm-ID: 235707 [Multi-domain]  Cd Length: 311  Bit Score: 196.53  E-value: 1.34e-58
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489189082   9 IGIVGTGAMGQGIAQLAACAGLSVLLYDSRQGVALQAREQIatvlarQVERGRLEAEAV-ERAMGNLRVVEDLRV-LGGC 86
Cdd:PRK06130   7 LAIIGAGTMGSGIAALFARKGLQVVLIDVMEGALERARGVI------ERALGVYAPLGIaSAGMGRIRMEAGLAAaVSGA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489189082  87 QLVIEAIVENLEAKQALFRQLEEVVGDEAILASNTSSLSVTAIASACRDPGRVAGLHFFNPVPLMRLVEVIEGLATRTGI 166
Cdd:PRK06130  81 DLVIEAVPEKLELKRDVFARLDGLCDPDTIFATNTSGLPITAIAQAVTRPERFVGTHFFTPADVIPLVEVVRGDKTSPQT 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489189082 167 AERLCALVATFGHQAVRAT-DSPGFIVNHAGRAFGTEALRILGEGVAPVAAIDEVLREGAGFRM---GPFELFDLVGLDV 242
Cdd:PRK06130 161 VATTMALLRSIGKRPVLVKkDIPGFIANRIQHALAREAISLLEKGVASAEDIDEVVKWSLGIRLaltGPLEQRDMNGLDV 240

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
gi 489189082 243 SLPVMESIYRQYyeEPRYRPHPLLRQMLAAGRLGRKSGQGFYRYDG 288
Cdd:PRK06130 241 HLAVASYLYQDL--ENRTTPSPLLEEKVEAGELGAKSGQGFYAWPP 284
PRK06035 PRK06035
3-hydroxyacyl-CoA dehydrogenase; Validated
 6-278 2.35e-57

3-hydroxyacyl-CoA dehydrogenase; Validated


Pssm-ID: 180361 [Multi-domain]  Cd Length: 291  Bit Score: 192.40  E-value: 2.35e-57
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489189082   6 IVLIGIVGTGAMGQGIAQLAACAGLSVLLYDSRQGVALQAREQIATV---LARQVERGRLEAEAVERAMGNLRVVEDLRV 82
Cdd:PRK06035   3 IKVIGVVGSGVMGQGIAQVFARTGYDVTIVDVSEEILKNAMELIESGpygLRNLVEKGKMSEDEAKAIMARIRTSTSYES 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489189082  83 LGGCQLVIEAIVENLEAKQALFRQLEEVVGDEAILASNTSSLSVTAIASACRDPGRVAGLHFFNPVPLMRLVEVIEGLAT 162
Cdd:PRK06035  83 LSDADFIVEAVPEKLDLKRKVFAELERNVSPETIIASNTSGIMIAEIATALERKDRFIGMHWFNPAPVMKLIEVVRAALT 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489189082 163 RTGIAERLCALVATFGHQAVRATDSPGFIVNHAGRAFGTEALRILGEGVAPVAAIDEVLREGAGFRMGPFELFDLVGLDV 242
Cdd:PRK06035 163 SEETFNTTVELSKKIGKIPIEVADVPGFFTTRFIEGWLLEAIRSFEIGIATIKDIDEMCKLAFGFPMGPFELMDIIGIDT 242

                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 489189082 243 SLPVMESIYRQyYEEPRYRPHPLLRQMLAAGRLGRK 278
Cdd:PRK06035 243 VYHIAEYLYEE-TGDPQFIPPNSLKQMVLNGYVGDK 277
fadB PRK11730
fatty acid oxidation complex subunit alpha FadB;
13-286 1.79e-47

fatty acid oxidation complex subunit alpha FadB;


Pssm-ID: 183293 [Multi-domain]  Cd Length: 715  Bit Score: 175.05  E-value: 1.79e-47
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489189082  13 GTGAMGQGIAQLAACAGLSVLLYD-SRQGVALQAREQiATVLARQVERGRLEAEAVERAMGNLRVVEDLRVLGGCQLVIE 91
Cdd:PRK11730 320 GAGIMGGGIAYQSASKGVPVIMKDiNQKALDLGMTEA-AKLLNKQVERGKIDGAKMAGVLSSIRPTLDYAGFERVDVVVE 398

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489189082  92 AIVENLEAKQALFRQLEEVVGDEAILASNTSSLSVTAIASACRDPGRVAGLHFFNPVPLMRLVEVIEGLATRTGIAERLC 171
Cdd:PRK11730 399 AVVENPKVKAAVLAEVEQKVREDTILASNTSTISISLLAKALKRPENFCGMHFFNPVHRMPLVEVIRGEKTSDETIATVV 478

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489189082 172 ALVATFGHQAVRATDSPGFIVNhagR-------AFGtealRILGEGvAPVAAIDEVLREGAGFRMGPFELFDLVGLDVS- 243
Cdd:PRK11730 479 AYASKMGKTPIVVNDCPGFFVN---RvlfpyfaGFS----QLLRDG-ADFRQIDKVMEKQFGWPMGPAYLLDVVGIDTAh 550

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*..
gi 489189082 244 --LPVMESIY--RQYYEEPryrphPLLRQMLAAGRLGRKSGQGFYRY 286
Cdd:PRK11730 551 haQAVMAEGFpdRMKKDYR-----DAIDVLFEAKRFGQKNGKGFYRY 592
fadJ PRK11154
fatty acid oxidation complex subunit alpha FadJ;
9-500 1.71e-46

fatty acid oxidation complex subunit alpha FadJ;


Pssm-ID: 236864 [Multi-domain]  Cd Length: 708  Bit Score: 172.39  E-value: 1.71e-46
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489189082   9 IGIVGTGAMGQGIAQLAAC-AGLSVLLYDSRQGVALQAREQIATVLARQVERGRLEAEAVERAMGNLRVVEDLRVLGGCQ 87
Cdd:PRK11154 312 VGVLGGGLMGGGIAYVTATkAGLPVRIKDINPQGINHALKYSWDLLDKKVKRRHLKPSERDKQMALISGTTDYRGFKHAD 391

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489189082  88 LVIEAIVENLEAKQALFRQLEEVVGDEAILASNTSSLSVTAIASACRDPGRVAGLHFFNPVPLMRLVEVIeglaTRTGIA 167
Cdd:PRK11154 392 VVIEAVFEDLALKQQMVAEVEQNCAPHTIFASNTSSLPIGQIAAAAARPEQVIGLHYFSPVEKMPLVEVI----PHAKTS 467

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489189082 168 ERLCALVATFGHQ----AVRATDSPGFIVNHAGRAFGTEALRILGEGVaPVAAIDEVLREgAGFRMGPFELFDLVGLDVS 243
Cdd:PRK11154 468 AETIATTVALAKKqgktPIVVRDGAGFYVNRILAPYINEAARLLLEGE-PIEHIDAALVK-FGFPVGPITLLDEVGIDVG 545

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489189082 244 ---LPVMESIYrqyyeEPRYRPHPLLRQMLAAGRLGRKSGQGFYRYDGAGQvpvaapavapgaalppvwlgvddehdrap 320
Cdd:PRK11154 546 tkiIPILEAAL-----GERFSAPAAFDKLLNDDRKGRKNGRGFYLYGQKGK----------------------------- 591

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489189082 321 llmllqrlgaevESGERPSGAALCLLaplgadvsaaarrfAVDPTRSLAIDVLSDlerhRCLMACpatraeLQQAARTLf 400
Cdd:PRK11154 592 ------------KSKKQVDESVYPLL--------------GITPQSRLSANEIAE----RCVMLM------LNEAVRCL- 634

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489189082 401 aRDGVgvtlirdsagfivqrtlasivnlacdiaqqgIASVEHIDLAVRLGLGYPL---GPLEWGDRLGAGRVLRILERLH 477
Cdd:PRK11154 635 -DEGI-------------------------------IRSARDGDIGAVFGIGFPPflgGPFRYMDSLGAGEVVAILERLA 682

                        490       500
                 ....*....|....*....|...
gi 489189082 478 ALSGDpRYRPSPWLRRRAQLGLS 500
Cdd:PRK11154 683 AQYGD-RFTPCERLVEMAERGES 704
fa_ox_alpha_mit TIGR02441
fatty acid oxidation complex, alpha subunit, mitochondrial; Members represent alpha subunit of ...
 9-288 8.08e-46

fatty acid oxidation complex, alpha subunit, mitochondrial; Members represent alpha subunit of mitochondrial multifunctional fatty acid degradation enzyme complex. Subunit activities include: enoyl-CoA hydratase (EC 4.2.1.17) _ 3-hydroxyacyl-CoA dehydrogenase (EC 1.1.1.35). Some characterization in human (SP:P40939), pig (SP:Q29554), and rat (SP:Q64428). The beta subunit has activity: acetyl-CoA C-acyltransferase (EC 2.3.1.16).


Pssm-ID: 131494 [Multi-domain]  Cd Length: 737  Bit Score: 170.79  E-value: 8.08e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489189082    9 IGIVGTGAMGQGIAQLAACAGLSVLLYDSRQGVALQAREQIATVLARQVERGRLEAEAVERAMGNLRVVEDLRVLGGCQL 88
Cdd:TIGR02441 338 LAVLGAGLMGAGIAQVSVDKGLKTVLKDATPAGLDRGQQQVFKGLNKKVKRKKITSLERDSILSNLTPTLDYSGFKNADM 417

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489189082   89 VIEAIVENLEAKQALFRQLEEVVGDEAILASNTSSLSVTAIASACRDPGRVAGLHFFNPVPLMRLVEVIEGLATRTGIAE 168
Cdd:TIGR02441 418 VIEAVFEDLSLKHKVIKEVEAVVPPHCIIASNTSALPIKDIAAVSSRPEKVIGMHYFSPVDKMQLLEIITHDGTSKDTLA 497

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489189082  169 RLCALVATFGHQAVRATDSPGFIVNHAGRAFGTEALRILGEGVAPvAAIDEvLREGAGFRMGPFELFDLVGLDVSLPVME 248
Cdd:TIGR02441 498 SAVAVGLKQGKVVIVVKDGPGFYTTRCLGPMLAEVIRLLQEGVDP-KKLDK-LTTKFGFPVGAATLADEVGVDVAEHVAE 575

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|
gi 489189082  249 SIYRQYYEEPRYRPHPLLRQMLAAGRLGRKSGQGFYRYDG 288
Cdd:TIGR02441 576 DLGKAFGERFGGGSAELLSELVKAGFLGRKSGKGIFIYQE 615
PRK08269 PRK08269
3-hydroxybutyryl-CoA dehydrogenase; Validated
 17-289 3.31e-45

3-hydroxybutyryl-CoA dehydrogenase; Validated


Pssm-ID: 181340 [Multi-domain]  Cd Length: 314  Bit Score: 160.99  E-value: 3.31e-45
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489189082  17 MGQGIAQLAACAGLSVLLYDSRQ-------GVALQAREQIATVLARQVERGRLEAEAVERAMGNLRVV---EDLRVLGGC 86
Cdd:PRK08269   1 MGQGIALAFAFAGHDVTLIDFKPrdaagwrALDAEARAEIERTLAALVALGRIDAAQADAVLARIAVVardGAADALADA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489189082  87 QLVIEAIVENLEAKQALFRQLEEVVGDEAILASNTSSLSVTAIASACRDPGRVAGLHFFNPVPLMRLVEVIEGLATRTGI 166
Cdd:PRK08269  81 DLVFEAVPEVLDAKREALRWLGRHVDADAIIASTTSTFLVTDLQRHVAHPERFLNAHWLNPAYLMPLVEVSPSDATDPAV 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489189082 167 AERLCALVATFGHQAVRATDSPGFIVNHAGRAFGTEALRILGEGVAPVAAIDEVLREGAGFR---MGPFELFDLVGLDVs 243
Cdd:PRK08269 161 VDRLAALLERIGKVPVVCGPSPGYIVPRIQALAMNEAARMVEEGVASAEDIDKAIRTGFGLRfavLGLLEFIDWGGCDI- 239

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
gi 489189082 244 LPVMESIYRQYYEEPRYRPHPLLRQMLAAGRLGRKSGQGFYRYDGA 289
Cdd:PRK08269 240 LYYASRYLAGEIGPDRFAPPAIVVRNMEEGRDGLRTGAGFYDYAGV 285
PRK08293 PRK08293
3-hydroxyacyl-CoA dehydrogenase;
9-286 1.91e-41

3-hydroxyacyl-CoA dehydrogenase;


Pssm-ID: 181359 [Multi-domain]  Cd Length: 287  Bit Score: 150.09  E-value: 1.91e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489189082   9 IGIVGTGAMGQGIAQLAACAGLSVLLYDSRQGVALQAREQIATVLARQVERGRLEAEA-VERAMGNLRVVEDLRV-LGGC 86
Cdd:PRK08293   6 VTVAGAGVLGSQIAFQTAFHGFDVTIYDISDEALEKAKERIAKLADRYVRDLEATKEApAEAALNRITLTTDLAEaVKDA 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489189082  87 QLVIEAIVENLEAKQALFRQLEEVVGDEAILASNTSSLSVTAIASACRDPGRVAGLHFFNPVPLMRLVEVIEGLATRTGI 166
Cdd:PRK08293  86 DLVIEAVPEDPEIKGDFYEELAKVAPEKTIFATNSSTLLPSQFAEATGRPEKFLALHFANEIWKNNTAEIMGHPGTDPEV 165

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489189082 167 AERLCALVATFGHQAVR-ATDSPGFIVNHAGRAFGTEALRILGEGVAPVAAIDEVLREGAGFRMGPFELFDLVGLDVSLP 245
Cdd:PRK08293 166 FDTVVAFAKAIGMVPIVlKKEQPGYILNSLLVPFLSAALALWAKGVADPETIDKTWMIATGAPMGPFGILDIVGLDTAYN 245

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|.
gi 489189082 246 VMESIYRQYYEEPRYRPHPLLRQMLAAGRLGRKSGQGFYRY 286
Cdd:PRK08293 246 ITSNWAEATDDENAKKAAALLKEYIDKGKLGVATGEGFYNY 286
3HCDH pfam00725
3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; This family also includes lambda ...
 189-286 2.43e-38

3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; This family also includes lambda crystallin. Some proteins include two copies of this domain.


Pssm-ID: 395588 [Multi-domain]  Cd Length: 97  Bit Score: 135.42  E-value: 2.43e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489189082  189 GFIVNHAGRAFGTEALRILGEGVAPVAAIDEVLREGAGFRMGPFELFDLVGLDVSLPVMEsIYRQYYEEPRYRPHPLLRQ 268
Cdd:pfam00725   1 GFVVNRLLAPYLNEAIRLVEEGVATPEDIDAAMRLGLGLPMGPFELSDLVGLDVGYHILE-VLAEEFGDRAYRPPPLLEK 79

                          90
                  ....*....|....*...
gi 489189082  269 MLAAGRLGRKSGQGFYRY 286
Cdd:pfam00725  80 LVEAGRLGRKTGKGFYKY 97
PRK06129 PRK06129
3-hydroxyacyl-CoA dehydrogenase; Validated
 9-237 3.73e-35

3-hydroxyacyl-CoA dehydrogenase; Validated


Pssm-ID: 235706 [Multi-domain]  Cd Length: 308  Bit Score: 133.63  E-value: 3.73e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489189082   9 IGIVGTGAMGQGIAQLAACAGLSVLLYDSRQGVALQAREQIATVLARQVERGRLEAEAVERAMGNLRVVEDL-RVLGGCQ 87
Cdd:PRK06129   5 VAIIGAGLIGRAWAIVFARAGHEVRLWDADPAAAAAAPAYIAGRLEDLAAFDLLDGEAPDAVLARIRVTDSLaDAVADAD 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489189082  88 LVIEAIVENLEAKQALFRQLEEVVGDEAILASNTSSLSVTAIASACRDPGRVAGLHFFNPVPLMRLVEVIEGLATRTGIA 167
Cdd:PRK06129  85 YVQESAPENLELKRALFAELDALAPPHAILASSTSALLASAFTEHLAGRERCLVAHPINPPYLIPVVEVVPAPWTAPATL 164

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 489189082 168 ERLCALVATFGHQAVRAT-DSPGFIVNHAGRAFGTEALRILGEGVAPVAAIDEVLREGAGFR---MGPFELFDL 237
Cdd:PRK06129 165 ARAEALYRAAGQSPVRLRrEIDGFVLNRLQGALLREAFRLVADGVASVDDIDAVIRDGLGLRwsfMGPFETIDL 238
3HCDH pfam00725
3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; This family also includes lambda ...
 415-498 1.26e-26

3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; This family also includes lambda crystallin. Some proteins include two copies of this domain.


Pssm-ID: 395588 [Multi-domain]  Cd Length: 97  Bit Score: 103.45  E-value: 1.26e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489189082  415 GFIVQRTLASIVNLACDIAQQGIASVEHIDLAVRLGLGYPLGPLEWGDRLGAGRVLRILERLHALSGDPRYRPSPWLRRR 494
Cdd:pfam00725   1 GFVVNRLLAPYLNEAIRLVEEGVATPEDIDAAMRLGLGLPMGPFELSDLVGLDVGYHILEVLAEEFGDRAYRPPPLLEKL 80


                  ....
gi 489189082  495 AQLG 498
Cdd:pfam00725  81 VEAG 84
FadB COG1250
3-hydroxyacyl-CoA dehydrogenase [Lipid transport and metabolism]; 3-hydroxyacyl-CoA ...
 382-493 3.12e-21

3-hydroxyacyl-CoA dehydrogenase [Lipid transport and metabolism]; 3-hydroxyacyl-CoA dehydrogenase is part of the Pathway/BioSystem: Fatty acid biosynthesis


Pssm-ID: 440862 [Multi-domain]  Cd Length: 281  Bit Score: 93.64  E-value: 3.12e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489189082 382 LMACPATRAELQQAARTLFARDGVGVTLIRDSAGFIVQRTLASIVNLACDIAQQGIASVEHIDLAVRLGLGYPLGPLEWG 461
Cdd:COG1250  152 VIRGPATSDETVATAVAFARRLGKTPVVVKDTPGFIVNRILVPYLNEAIRLLEEGVASPEDIDAAMRLGFGFPMGPFELA 231

                         90       100       110
                 ....*....|....*....|....*....|..
gi 489189082 462 DRLGAGRVLRILERLHALSGDPRYRPSPWLRR 493
Cdd:COG1250  232 DLVGLDTALAVLEVLYEALGDPRYRPPPLLKK 263
PRK07066 PRK07066
L-carnitine dehydrogenase;
12-286 1.35e-19

L-carnitine dehydrogenase;


Pssm-ID: 168796 [Multi-domain]  Cd Length: 321  Bit Score: 89.51  E-value: 1.35e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489189082  12 VGTGAMGQGIAQLAACAGLSVLLYDSRQGVALQAREQIATVLArQVERGRLEAEAVERAMGNLRVVEDlrVLGGCQLVIE 91
Cdd:PRK07066  13 IGSGVIGSGWVARALAHGLDVVAWDPAPGAEAALRANVANAWP-ALERQGLAPGASPARLRFVATIEA--CVADADFIQE 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489189082  92 AIVENLEAKQALFRQLEEVVGDEAILASNTSSLSVTAIASACRDPGRVAGLHFFNPVPLMRLVEVIEGLATRTGIAERLC 171
Cdd:PRK07066  90 SAPEREALKLELHERISRAAKPDAIIASSTSGLLPTDFYARATHPERCVVGHPFNPVYLLPLVEVLGGERTAPEAVDAAM 169

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489189082 172 ALVATFGHQAVRA-TDSPGFIVNHAGRAFGTEALRILGEGVAPVAAIDEVLREGAGFR---MGPFELFDLVGLDVSLPVM 247
Cdd:PRK07066 170 GIYRALGMRPLHVrKEVPGFIADRLLEALWREALHLVNEGVATTGEIDDAIRFGAGIRwsfMGTFLTYTLAGGDAGMRHF 249

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*..
gi 489189082 248 ESIYRQYYEEP-RYRPHPLLRQML-------AAGRLGRKSGQGFYRY 286
Cdd:PRK07066 250 MQQFGPALELPwTKLVAPELTDALidrvvegTAEQQGPRSIKALERY 296
PLN02545 PLN02545
3-hydroxybutyryl-CoA dehydrogenase
 388-499 8.38e-17

3-hydroxybutyryl-CoA dehydrogenase


Pssm-ID: 215300 [Multi-domain]  Cd Length: 295  Bit Score: 80.93  E-value: 8.38e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489189082 388 TRAELQQAARTLFARDGVGVTLIRDSAGFIVQRTLASIVNLACDIAQQGIASVEHIDLAVRLGLGYPLGPLEWGDRLGAG 467
Cdd:PLN02545 160 TSDEVFDATKALAERFGKTVVCSQDYPGFIVNRILMPMINEAFYALYTGVASKEDIDTGMKLGTNHPMGPLHLADFIGLD 239

                         90       100       110
                 ....*....|....*....|....*....|..
gi 489189082 468 RVLRILERLHALSGDPRYRPSPWLRRRAQLGL 499
Cdd:PLN02545 240 TCLSIMKVLHEGLGDSKYRPCPLLVQYVDAGR 271
PRK07531 PRK07531
carnitine 3-dehydrogenase;
9-239 1.23e-16

carnitine 3-dehydrogenase;


Pssm-ID: 236044 [Multi-domain]  Cd Length: 495  Bit Score: 82.48  E-value: 1.23e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489189082   9 IGIVGTGAMGQGIAQLAACAGLSVLLYDSRQgvalQAREQIATVLArQVER--GRLEAEAVERAmGNLRVVEDL-RVLGG 85
Cdd:PRK07531   7 AACIGGGVIGGGWAARFLLAGIDVAVFDPHP----EAERIIGEVLA-NAERayAMLTDAPLPPE-GRLTFCASLaEAVAG 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489189082  86 CQLVIEAIVENLEAKQALFRQLEEVVGDEAILASNTSSLSVTAIASACRDPGRVAGLHFFNPVPLMRLVEVIEGLATRTG 165
Cdd:PRK07531  81 ADWIQESVPERLDLKRRVLAEIDAAARPDALIGSSTSGFLPSDLQEGMTHPERLFVAHPYNPVYLLPLVELVGGGKTSPE 160

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 489189082 166 IAERLCALVATFGHQAVR-ATDSPGFIVNHAGRAFGTEALRILGEGVAPVAAIDEVLREGAGFR---MGPFELFDLVG 239
Cdd:PRK07531 161 TIRRAKEILREIGMKPVHiAKEIDAFVGDRLLEALWREALWLVKDGIATTEEIDDVIRYSFGLRwaqMGLFETYRIAG 238
PRK05808 PRK05808
3-hydroxybutyryl-CoA dehydrogenase; Validated
 410-492 4.57e-16

3-hydroxybutyryl-CoA dehydrogenase; Validated


Pssm-ID: 180269 [Multi-domain]  Cd Length: 282  Bit Score: 78.47  E-value: 4.57e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489189082 410 IRDSAGFIVQRTLASIVNLACDIAQQGIASVEHIDLAVRLGLGYPLGPLEWGDRLGAGRVLRILERLHALSGDPRYRPSP 489
Cdd:PRK05808 181 VKNAPGFVVNRILIPMINEAIFVLAEGVATAEDIDEGMKLGCNHPIGPLALADLIGLDTCLAIMEVLYEGFGDSKYRPCP 260


                 ...
gi 489189082 490 WLR 492
Cdd:PRK05808 261 LLR 263
PRK07530 PRK07530
3-hydroxybutyryl-CoA dehydrogenase; Validated
 387-498 7.22e-15

3-hydroxybutyryl-CoA dehydrogenase; Validated


Pssm-ID: 181018 [Multi-domain]  Cd Length: 292  Bit Score: 75.04  E-value: 7.22e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489189082 387 ATRAELQQAARTLFARDGVGVTLIRDSAGFIVQRTLASIVNLACDIAQQGIASVEHIDLAVRLGLGYPLGPLEWGDRLGA 466
Cdd:PRK07530 159 ATDEATFEAAKEFVTKLGKTITVAEDFPAFIVNRILLPMINEAIYTLYEGVGSVEAIDTAMKLGANHPMGPLELADFIGL 238

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 489189082 467 GRVLRILERLHALSGDPRYRPSP---------WLRRRAQLG 498
Cdd:PRK07530 239 DTCLSIMQVLHDGLADSKYRPCPllvkyveagWLGRKTGRG 279
PRK09260 PRK09260
3-hydroxyacyl-CoA dehydrogenase;
387-498 3.25e-13

3-hydroxyacyl-CoA dehydrogenase;


Pssm-ID: 236434 [Multi-domain]  Cd Length: 288  Bit Score: 70.20  E-value: 3.25e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489189082 387 ATRAELQQAARTLFARDGVGVTLIRDSAGFIVQRTLASIVNLACDIAQQGIASVEHIDLAVRLGLGYPLGPLEWGDRLGA 466
Cdd:PRK09260 157 ETSDETVQVAKEVAEQMGKETVVVNEFPGFVTSRISALVGNEAFYMLQEGVATAEDIDKAIRLGLNFPMGPLELGDLVGL 236

                         90       100       110
                 ....*....|....*....|....*....|..
gi 489189082 467 GRVLRILERLHALSGDpRYRPSPWLRRRAQLG 498
Cdd:PRK09260 237 DTRLNNLKYLHETLGE-KYRPAPLLEKYVKAG 267
PRK07819 PRK07819
3-hydroxybutyryl-CoA dehydrogenase; Validated
 388-499 7.25e-13

3-hydroxybutyryl-CoA dehydrogenase; Validated


Pssm-ID: 181133 [Multi-domain]  Cd Length: 286  Bit Score: 68.86  E-value: 7.25e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489189082 388 TRAELQQAARTlFARDGVGVTLIR--DSAGFIVQRTLASIVNLACDIAQQGIASVEHIDLAVRLGLGYPLGPLEWGDRLG 465
Cdd:PRK07819 162 TSEATVARAEE-FASDVLGKQVVRaqDRSGFVVNALLVPYLLSAIRMVESGFATAEDIDKAMVLGCAHPMGPLRLSDLVG 240

                         90       100       110
                 ....*....|....*....|....*....|....
gi 489189082 466 AGRVLRILERLHALSGDPRYRPSPWLRRRAQLGL 499
Cdd:PRK07819 241 LDTVKAIADSMYEEFKEPLYAPPPLLLRMVEAGL 274
PRK06035 PRK06035
3-hydroxyacyl-CoA dehydrogenase; Validated
 412-493 6.31e-08

3-hydroxyacyl-CoA dehydrogenase; Validated


Pssm-ID: 180361 [Multi-domain]  Cd Length: 291  Bit Score: 54.11  E-value: 6.31e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489189082 412 DSAGFIVQRTLASIVNLACDIAQQGIASVEHIDLAVRLGLGYPLGPLEWGDRLGAGRVLRILERLHALSGDPRYRPSPWL 491
Cdd:PRK06035 186 DVPGFFTTRFIEGWLLEAIRSFEIGIATIKDIDEMCKLAFGFPMGPFELMDIIGIDTVYHIAEYLYEETGDPQFIPPNSL 265


                 ..
gi 489189082 492 RR 493
Cdd:PRK06035 266 KQ 267
PRK06130 PRK06130
3-hydroxybutyryl-CoA dehydrogenase; Validated
 386-498 4.46e-06

3-hydroxybutyryl-CoA dehydrogenase; Validated


Pssm-ID: 235707 [Multi-domain]  Cd Length: 311  Bit Score: 48.62  E-value: 4.46e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489189082 386 PATRAELQQAARTLFARDgvgVTLIRDSAGFIVQRTLASIVNLACDIAQQGIASVEHIDLAVRLGLGYPL---GPLEWGD 462
Cdd:PRK06130 158 PQTVATTMALLRSIGKRP---VLVKKDIPGFIANRIQHALAREAISLLEKGVASAEDIDEVVKWSLGIRLaltGPLEQRD 234

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 489189082 463 RLGAGRVLRILERLHAlSGDPRYRPSPWLRRRAQLG 498
Cdd:PRK06130 235 MNGLDVHLAVASYLYQ-DLENRTTPSPLLEEKVEAG 269
PRK06129 PRK06129
3-hydroxyacyl-CoA dehydrogenase; Validated
 378-490 1.21e-03

3-hydroxyacyl-CoA dehydrogenase; Validated


Pssm-ID: 235706 [Multi-domain]  Cd Length: 308  Bit Score: 40.80  E-value: 1.21e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489189082 378 RHRCLMA----------------CPATRAELQQAARTLFARDG-VGVTLIRDSAGFIVQRTLASIVNLACDIAQQGIASV 440
Cdd:PRK06129 133 RERCLVAhpinppylipvvevvpAPWTAPATLARAEALYRAAGqSPVRLRREIDGFVLNRLQGALLREAFRLVADGVASV 212

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 489189082 441 EHIDLAVRLGLGYP---LGPLEWGDRLGAGRVLRILER---LHALSGDPRYRPSPW 490
Cdd:PRK06129 213 DDIDAVIRDGLGLRwsfMGPFETIDLNAPGGVADYAQRygpMYRRMAAERGQPVPW 268
PRK08269 PRK08269
3-hydroxybutyryl-CoA dehydrogenase; Validated
 386-493 2.82e-03

3-hydroxybutyryl-CoA dehydrogenase; Validated


Pssm-ID: 181340 [Multi-domain]  Cd Length: 314  Bit Score: 39.66  E-value: 2.82e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489189082 386 PATRAELQQAARTLFARDGVGVTLIRDSAGFIVQRTLASIVNLACDIAQQGIASVEHIDLAVRLGLGYP---LGPLEWGD 462
Cdd:PRK08269 154 DATDPAVVDRLAALLERIGKVPVVCGPSPGYIVPRIQALAMNEAARMVEEGVASAEDIDKAIRTGFGLRfavLGLLEFID 233

                         90       100       110
                 ....*....|....*....|....*....|..
gi 489189082 463 rLGAGRVLRILER-LHALSGDPRYRPSPWLRR 493
Cdd:PRK08269 234 -WGGCDILYYASRyLAGEIGPDRFAPPAIVVR 264
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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