|
Name |
Accession |
Description |
Interval |
E-value |
| PRK01318 |
PRK01318 |
membrane protein insertase; Provisional |
1-576 |
0e+00 |
|
membrane protein insertase; Provisional
Pssm-ID: 234942 [Multi-domain] Cd Length: 521 Bit Score: 704.32 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489187856 1 MDIQRSILIVALAVVSYLLVLQWNKDYGQPELPAASASmnttqglpdtpsasgtssdvptaqssaagseaadkpvavsdK 80
Cdd:PRK01318 1 MDNKRLLLAIALSFVIFLGWQYWQQDKAQAAAQAPAPQ-----------------------------------------A 39
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489187856 81 LIQVKTDVLDLAIDPRGGDIVQLGLLQYPRRLDrPDVPFPLFDNGRERTYLAQSGLTGADGPDASSAG-RPLFHSAQSSY 159
Cdd:PRK01318 40 RITVETDVLRLSIDTKGGRIDDLLLKKYKETLD-SSPPVVLLSPSTEHPYFAQSGLTGADGPDNVPNPdRTLYTADGDSL 118
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489187856 160 QLADGQNELVVDLSFSH-DGVNYIKRFTFHRGLkadcsdkekaqkkiecinenaYQVGVSYLIDNQSGKTWSGNLFAQLK 238
Cdd:PRK01318 119 VLADGQNELPVTLTWTNgNGLTFTKTYTLDRGD---------------------YMFTVEYSVNNNSGAPVNLSPYGQLK 177
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489187856 239 RDGsadpssTTATGVSTYLGAAVWTPDSPYKKISTKDMDKEQfKESVQGGWVAWLQHYFVTAWVPTKGEQhQVMTRKDGQ 318
Cdd:PRK01318 178 RTG------SSNFASYTFHGGAIGTPDEKYEKYTYKDIDDNL-NISSKGGWVAILDKYFATALIPQNGQN-NFYSKNLGN 249
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489187856 319 GNYIVGFTGPTLSVPAGSKVETDLTLYAGPKLQKHLK-ELSPGLELTVDYGFLWFIAQPIFWLLQHIHSLIGNWGWSIIA 397
Cdd:PRK01318 250 GLYQVGFKSPPVTVAPGQSASTTARLYAGPKEVKLLAkEIAPGLDLAVDYGWLWFITKPLFWLLDFLHSFVGNWGWAIIL 329
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489187856 398 LTVLIKLAFFPLSAASYRSMARMRAVSPKMQAIKEQHGDDRQKMSQAMMELYKKEKINPLGGCLPILVQMPVFLSLYWVL 477
Cdd:PRK01318 330 LTIIVKLLLFPLTYKSYVSMAKMKVLQPKMQELKEKYKDDPQKMQQEMMELYKKEKVNPLGGCLPILIQIPIFFALYKVL 409
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489187856 478 LESVEMRQAPWLGWITDLSVKDPFFIL-----PIVMGGTMLIQQMLNPTPPDPMQAKVMKLMPIIFTFFFLWFPAGLVLY 552
Cdd:PRK01318 410 LVSIELRHAPFIGWIHDLSAPDPYFILhigllPILMGITMFLQQKLNPTPTDPMQAKIMKFMPLIFTFFFLSFPAGLVLY 489
|
570 580
....*....|....*....|....
gi 489187856 553 WVVNNCLSIAQQWYITRKIEAAAK 576
Cdd:PRK01318 490 WIVNNLLTIIQQYLINRRLEKKKL 513
|
|
| YidC |
COG0706 |
Membrane protein insertase Oxa1/YidC/SpoIIIJ [Cell wall/membrane/envelope biogenesis]; |
365-575 |
2.33e-124 |
|
Membrane protein insertase Oxa1/YidC/SpoIIIJ [Cell wall/membrane/envelope biogenesis];
Pssm-ID: 440470 [Multi-domain] Cd Length: 212 Bit Score: 364.44 E-value: 2.33e-124
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489187856 365 VDYGFLWFIAQPIFWLLQHIHSLIGNWGWSIIALTVLIKLAFFPLSAASYRSMARMRAVSPKMQAIKEQHGDDRQKMSQA 444
Cdd:COG0706 1 IDYGWFGFIAKPLFWLLNFLHSLVGNWGLAIILLTLIVRLLLFPLTVKQYKSMAKMQELQPELKEIQEKYKDDPQKLQQE 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489187856 445 MMELYKKEKINPLGGCLPILVQMPVFLSLYWVLLESVEMRQAPWLgWITDLSVKDPFFI-LPIVMGGTMLIQQMLNPTP- 522
Cdd:COG0706 81 MMKLYKEEGVNPLGGCLPMLIQMPIFIALYRVLRNSIELRHAPFL-GIPDLSAPDPYYIfLPILMGVTMFLQQKLNPAPa 159
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|...
gi 489187856 523 PDPMQAKVMKLMPIIFTFFFLWFPAGLVLYWVVNNCLSIAQQWYITRKIEAAA 575
Cdd:COG0706 160 QDPQQKKMMYIMPLMFLFFFLSFPAGLVLYWVVSNLLTIGQQLIINRRLDKKK 212
|
|
| yidC_nterm |
TIGR03593 |
membrane protein insertase, YidC/Oxa1 family, N-terminal domain; Essentially all bacteria have ... |
3-389 |
7.05e-121 |
|
membrane protein insertase, YidC/Oxa1 family, N-terminal domain; Essentially all bacteria have a member of the YidC family, whose C-terminal domain is modeled by TIGR03592. The two copies are found in endospore-forming bacteria such as Bacillus subtilis appear redundant during vegetative growth, although the member designated spoIIIJ (stage III sporulation protein J) has a distinct role in spore formation. YidC, its mitochondrial homolog Oxa1, and its chloroplast homolog direct insertion into the bacterial/organellar inner (or only) membrane. This model describes an N-terminal sequence region, including a large periplasmic domain lacking in YidC members from Gram-positive species. The multifunctional YidC protein acts both with and independently of the Sec system. [Protein fate, Protein and peptide secretion and trafficking]
Pssm-ID: 274666 Cd Length: 366 Bit Score: 361.26 E-value: 7.05e-121
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489187856 3 IQRSILIVALAVVSYLLVLQWNKDYGQPELPAASASMNTTQglPDTPSASGTSSDVPTAQSSAAGSEAADKpvAVSDKLI 82
Cdd:TIGR03593 1 NRRLILAIALSFVIFLLWQAWQSDPGPPPPKPPAAAQEASA--ASATAAATSAAAPAAADAPSAAAAADAA--AATAKRI 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489187856 83 QVKTDVLDLAIDPRGGDIVQLGLLQYPRRLDRPDVPFPLFDNGRERTYLAQSGLTGADGPDASSAG-RPLFHSAQSSYQL 161
Cdd:TIGR03593 77 TVETDVLRASISTKGGDIDSLELKKYKETLDKDSPPVLLLSDGAERLYVAQSGLIGANGADLALPGhRTVWQAEGGEYTL 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489187856 162 ADGQneLVVDLSF-SHDGVNYIKRFTFHRGlkadcsdkekaqkkiecinenAYQVGVSYLIDNQSGKTWSGNLFAQLKRD 240
Cdd:TIGR03593 157 TPGQ--LPVTLTWdNSNGVTVTKTYTFDRD---------------------SYLIDVEYKVTNNGDAPVSLSLYGQLKRD 213
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489187856 241 GSADPSSTTATgVSTYLGAAVWTPDSPYKKISTKDMDKE--QFKESVQGGWVAWLQHYFVTAWVP---TKGEQHQVMTRK 315
Cdd:TIGR03593 214 LSPTEKSTYFL-HETFTGAAYYTDGEKYQKVSFKDIEKKklNVETKGGAGWVGMLQHYFASAWIPpagSDGTTAFYYGRK 292
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 489187856 316 DGQGNYIVGFTGPTLSVPAGSKVETDLTLYAGPKLQKHLKELSPGLELTVDYGFLWFIAQPIFWLLQHIHSLIG 389
Cdd:TIGR03593 293 LGNNVYIAGFVSPVVTVAPGQSATIKSRLYAGPKEQDVLKAIAPGLDLAVDYGWLWFIAKPLFWLLDFFHSLVG 366
|
|
| 60KD_IMP |
pfam02096 |
60Kd inner membrane protein; |
391-569 |
1.51e-102 |
|
60Kd inner membrane protein;
Pssm-ID: 460443 [Multi-domain] Cd Length: 187 Bit Score: 307.48 E-value: 1.51e-102
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489187856 391 WGWSIIALTVLIKLAFFPLSAASYRSMARMRAVSPKMQAIKEQHGDDRQKMSQAMMELYKKEKINPLGGCLPILVQMPVF 470
Cdd:pfam02096 1 YGLAIILLTILIKLILFPLTYKQYKSMAKMQELQPEMKEIQEKYKDDRQKLQQEMMKLYKKEGVNPLGGCLPMLIQMPIF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489187856 471 LSLYWVLLESVEMRQAPWLGWITDLSVKDP-----FFILPIVMGGTMLIQQMLNPTPPD-PMQAKVMKL--MPIIFTFFF 542
Cdd:pfam02096 81 IALYRVLRNSIELRHAPFFLWIADLSAPDPisilhYYILPILMGVTMFLQQKLTPAPQDqPPQMKMMMLyfMPLMFLFFF 160
|
170 180
....*....|....*....|....*..
gi 489187856 543 LWFPAGLVLYWVVNNCLSIAQQWYITR 569
Cdd:pfam02096 161 LNFPAGLVLYWVVSNLLSIGQQLIINR 187
|
|
| 5TM_YidC_Alb3 |
cd20070 |
Five transmembrane core domain of membrane protein insertase YidC, Alb3, and similar proteins; ... |
392-569 |
6.85e-102 |
|
Five transmembrane core domain of membrane protein insertase YidC, Alb3, and similar proteins; This group is composed of the bacterial and chloroplastic members of the YidC/Oxa1/Alb3 protein family of insertases, including bacterial YidC, and chloroplastic ALBINO3 (Alb3) and Alb3-like proteins such as ALBINO3-like protein 1 (also called Alb4). Membrane protein insertase YidC, also called foldase YidC or membrane integrase YidC, facilitates proper folding, insertion, and assembly of inner membrane proteins and complexes. Depending on the nature of the substrate, YidC functions in a Sec-independent (YidC only) or a Sec-dependent manner as part of a complex containing YidC, the SecYEG channel, and SecDFYajC. YidC from Gram-negative bacteria contains an extra transmembrane segment (TM1) at the N-terminus and a large periplasmic domain, located between TM1 and TM2, that adopts a beta-super sandwich fold that is found in sugar-binding proteins such as galactose mutarotase. Alb3 and Alb3-like proteins are required for the post-translational insertion of the light-harvesting chlorophyll-binding proteins (LHCPs) into the chloroplast thylakoid membrane. Alb3 acts independently and may also function cooperatively with the thylakoid cpSecYE translocase to insert proteins co-translationally into the thylakoid membrane, similar to bacterial YidC that can function with the SecYEG translocase. YidC/Oxa1/Alb3 family insertases contain a core domain of five transmembrane (5TM) segments that is essential to insertase function.
Pssm-ID: 410994 [Multi-domain] Cd Length: 181 Bit Score: 305.46 E-value: 6.85e-102
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489187856 392 GWSIIALTVLIKLAFFPLSAASYRSMARMRAVSPKMQAIKEQHGDDRQKMSQAMMELYKKEKINPLGGCLPILVQMPVFL 471
Cdd:cd20070 1 GLAIILLTILIRLLLLPLTLKQYKSMKKMQELQPKIKEIQEKYKDDKQKLQQEMMKLYKEHGVNPLGGCLPLLIQMPIFI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489187856 472 SLYWVLLESVEMRQAPWLGWITDLSVKDPFFILPIVMGGTMLIQQMLNPTPPD---PMQAKVMKLMPIIFTFFFLWFPAG 548
Cdd:cd20070 81 ALYQVLRNSIELRGAPFLWWILDLSAPDPYYILPILMGVTMFLQQKLTPTPTDdqaPQQKMMMYFMPVMFTFIFLSFPSG 160
|
170 180
....*....|....*....|.
gi 489187856 549 LVLYWVVNNCLSIAQQWYITR 569
Cdd:cd20070 161 LVLYWLVSNLFSIIQQLIINK 181
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| PRK01318 |
PRK01318 |
membrane protein insertase; Provisional |
1-576 |
0e+00 |
|
membrane protein insertase; Provisional
Pssm-ID: 234942 [Multi-domain] Cd Length: 521 Bit Score: 704.32 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489187856 1 MDIQRSILIVALAVVSYLLVLQWNKDYGQPELPAASASmnttqglpdtpsasgtssdvptaqssaagseaadkpvavsdK 80
Cdd:PRK01318 1 MDNKRLLLAIALSFVIFLGWQYWQQDKAQAAAQAPAPQ-----------------------------------------A 39
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489187856 81 LIQVKTDVLDLAIDPRGGDIVQLGLLQYPRRLDrPDVPFPLFDNGRERTYLAQSGLTGADGPDASSAG-RPLFHSAQSSY 159
Cdd:PRK01318 40 RITVETDVLRLSIDTKGGRIDDLLLKKYKETLD-SSPPVVLLSPSTEHPYFAQSGLTGADGPDNVPNPdRTLYTADGDSL 118
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489187856 160 QLADGQNELVVDLSFSH-DGVNYIKRFTFHRGLkadcsdkekaqkkiecinenaYQVGVSYLIDNQSGKTWSGNLFAQLK 238
Cdd:PRK01318 119 VLADGQNELPVTLTWTNgNGLTFTKTYTLDRGD---------------------YMFTVEYSVNNNSGAPVNLSPYGQLK 177
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489187856 239 RDGsadpssTTATGVSTYLGAAVWTPDSPYKKISTKDMDKEQfKESVQGGWVAWLQHYFVTAWVPTKGEQhQVMTRKDGQ 318
Cdd:PRK01318 178 RTG------SSNFASYTFHGGAIGTPDEKYEKYTYKDIDDNL-NISSKGGWVAILDKYFATALIPQNGQN-NFYSKNLGN 249
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489187856 319 GNYIVGFTGPTLSVPAGSKVETDLTLYAGPKLQKHLK-ELSPGLELTVDYGFLWFIAQPIFWLLQHIHSLIGNWGWSIIA 397
Cdd:PRK01318 250 GLYQVGFKSPPVTVAPGQSASTTARLYAGPKEVKLLAkEIAPGLDLAVDYGWLWFITKPLFWLLDFLHSFVGNWGWAIIL 329
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489187856 398 LTVLIKLAFFPLSAASYRSMARMRAVSPKMQAIKEQHGDDRQKMSQAMMELYKKEKINPLGGCLPILVQMPVFLSLYWVL 477
Cdd:PRK01318 330 LTIIVKLLLFPLTYKSYVSMAKMKVLQPKMQELKEKYKDDPQKMQQEMMELYKKEKVNPLGGCLPILIQIPIFFALYKVL 409
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489187856 478 LESVEMRQAPWLGWITDLSVKDPFFIL-----PIVMGGTMLIQQMLNPTPPDPMQAKVMKLMPIIFTFFFLWFPAGLVLY 552
Cdd:PRK01318 410 LVSIELRHAPFIGWIHDLSAPDPYFILhigllPILMGITMFLQQKLNPTPTDPMQAKIMKFMPLIFTFFFLSFPAGLVLY 489
|
570 580
....*....|....*....|....
gi 489187856 553 WVVNNCLSIAQQWYITRKIEAAAK 576
Cdd:PRK01318 490 WIVNNLLTIIQQYLINRRLEKKKL 513
|
|
| YidC |
COG0706 |
Membrane protein insertase Oxa1/YidC/SpoIIIJ [Cell wall/membrane/envelope biogenesis]; |
365-575 |
2.33e-124 |
|
Membrane protein insertase Oxa1/YidC/SpoIIIJ [Cell wall/membrane/envelope biogenesis];
Pssm-ID: 440470 [Multi-domain] Cd Length: 212 Bit Score: 364.44 E-value: 2.33e-124
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489187856 365 VDYGFLWFIAQPIFWLLQHIHSLIGNWGWSIIALTVLIKLAFFPLSAASYRSMARMRAVSPKMQAIKEQHGDDRQKMSQA 444
Cdd:COG0706 1 IDYGWFGFIAKPLFWLLNFLHSLVGNWGLAIILLTLIVRLLLFPLTVKQYKSMAKMQELQPELKEIQEKYKDDPQKLQQE 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489187856 445 MMELYKKEKINPLGGCLPILVQMPVFLSLYWVLLESVEMRQAPWLgWITDLSVKDPFFI-LPIVMGGTMLIQQMLNPTP- 522
Cdd:COG0706 81 MMKLYKEEGVNPLGGCLPMLIQMPIFIALYRVLRNSIELRHAPFL-GIPDLSAPDPYYIfLPILMGVTMFLQQKLNPAPa 159
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|...
gi 489187856 523 PDPMQAKVMKLMPIIFTFFFLWFPAGLVLYWVVNNCLSIAQQWYITRKIEAAA 575
Cdd:COG0706 160 QDPQQKKMMYIMPLMFLFFFLSFPAGLVLYWVVSNLLTIGQQLIINRRLDKKK 212
|
|
| yidC_nterm |
TIGR03593 |
membrane protein insertase, YidC/Oxa1 family, N-terminal domain; Essentially all bacteria have ... |
3-389 |
7.05e-121 |
|
membrane protein insertase, YidC/Oxa1 family, N-terminal domain; Essentially all bacteria have a member of the YidC family, whose C-terminal domain is modeled by TIGR03592. The two copies are found in endospore-forming bacteria such as Bacillus subtilis appear redundant during vegetative growth, although the member designated spoIIIJ (stage III sporulation protein J) has a distinct role in spore formation. YidC, its mitochondrial homolog Oxa1, and its chloroplast homolog direct insertion into the bacterial/organellar inner (or only) membrane. This model describes an N-terminal sequence region, including a large periplasmic domain lacking in YidC members from Gram-positive species. The multifunctional YidC protein acts both with and independently of the Sec system. [Protein fate, Protein and peptide secretion and trafficking]
Pssm-ID: 274666 Cd Length: 366 Bit Score: 361.26 E-value: 7.05e-121
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489187856 3 IQRSILIVALAVVSYLLVLQWNKDYGQPELPAASASMNTTQglPDTPSASGTSSDVPTAQSSAAGSEAADKpvAVSDKLI 82
Cdd:TIGR03593 1 NRRLILAIALSFVIFLLWQAWQSDPGPPPPKPPAAAQEASA--ASATAAATSAAAPAAADAPSAAAAADAA--AATAKRI 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489187856 83 QVKTDVLDLAIDPRGGDIVQLGLLQYPRRLDRPDVPFPLFDNGRERTYLAQSGLTGADGPDASSAG-RPLFHSAQSSYQL 161
Cdd:TIGR03593 77 TVETDVLRASISTKGGDIDSLELKKYKETLDKDSPPVLLLSDGAERLYVAQSGLIGANGADLALPGhRTVWQAEGGEYTL 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489187856 162 ADGQneLVVDLSF-SHDGVNYIKRFTFHRGlkadcsdkekaqkkiecinenAYQVGVSYLIDNQSGKTWSGNLFAQLKRD 240
Cdd:TIGR03593 157 TPGQ--LPVTLTWdNSNGVTVTKTYTFDRD---------------------SYLIDVEYKVTNNGDAPVSLSLYGQLKRD 213
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489187856 241 GSADPSSTTATgVSTYLGAAVWTPDSPYKKISTKDMDKE--QFKESVQGGWVAWLQHYFVTAWVP---TKGEQHQVMTRK 315
Cdd:TIGR03593 214 LSPTEKSTYFL-HETFTGAAYYTDGEKYQKVSFKDIEKKklNVETKGGAGWVGMLQHYFASAWIPpagSDGTTAFYYGRK 292
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 489187856 316 DGQGNYIVGFTGPTLSVPAGSKVETDLTLYAGPKLQKHLKELSPGLELTVDYGFLWFIAQPIFWLLQHIHSLIG 389
Cdd:TIGR03593 293 LGNNVYIAGFVSPVVTVAPGQSATIKSRLYAGPKEQDVLKAIAPGLDLAVDYGWLWFIAKPLFWLLDFFHSLVG 366
|
|
| yidC_oxa1_cterm |
TIGR03592 |
membrane protein insertase, YidC/Oxa1 family, C-terminal domain; This model describes ... |
390-567 |
7.97e-104 |
|
membrane protein insertase, YidC/Oxa1 family, C-terminal domain; This model describes full-length from some species, and the C-terminal region only from other species, of the YidC/Oxa1 family of proteins. This domain appears to be univeral among bacteria (although absent from Archaea). The well-characterized YidC protein from Escherichia coli and its close homologs contain a large N-terminal periplasmic domain in addition to the region modeled here. [Protein fate, Protein and peptide secretion and trafficking]
Pssm-ID: 274665 [Multi-domain] Cd Length: 179 Bit Score: 310.57 E-value: 7.97e-104
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489187856 390 NWGWSIIALTVLIKLAFFPLSAASYRSMARMRAVSPKMQAIKEQHGDDRQKMSQAMMELYKKEKINPLGGCLPILVQMPV 469
Cdd:TIGR03592 1 NWGLAIILLTIIVRLILLPLTLKQYKSMRKMQELQPKLKEIQEKYKEDPQKLQQEMMKLYKEEGVNPLGGCLPLLIQMPI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489187856 470 FLSLYWVLLESVEMRQAPWLgWITDLSVKDPFFILPIVMGGTMLIQQMLNPT-PPDPMQAKVM-KLMPIIFTFFFLWFPA 547
Cdd:TIGR03592 81 FIALYQVLLRSIELRHAPFL-WIIDLSSPDPYYILPILMGVTMFLQQKLSPKgPPDPAQQKMMmYFMPLMFLFFFLSFPA 159
|
170 180
....*....|....*....|
gi 489187856 548 GLVLYWVVNNCLSIAQQWYI 567
Cdd:TIGR03592 160 GLVLYWVVSNLFTIIQQLII 179
|
|
| 60KD_IMP |
pfam02096 |
60Kd inner membrane protein; |
391-569 |
1.51e-102 |
|
60Kd inner membrane protein;
Pssm-ID: 460443 [Multi-domain] Cd Length: 187 Bit Score: 307.48 E-value: 1.51e-102
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489187856 391 WGWSIIALTVLIKLAFFPLSAASYRSMARMRAVSPKMQAIKEQHGDDRQKMSQAMMELYKKEKINPLGGCLPILVQMPVF 470
Cdd:pfam02096 1 YGLAIILLTILIKLILFPLTYKQYKSMAKMQELQPEMKEIQEKYKDDRQKLQQEMMKLYKKEGVNPLGGCLPMLIQMPIF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489187856 471 LSLYWVLLESVEMRQAPWLGWITDLSVKDP-----FFILPIVMGGTMLIQQMLNPTPPD-PMQAKVMKL--MPIIFTFFF 542
Cdd:pfam02096 81 IALYRVLRNSIELRHAPFFLWIADLSAPDPisilhYYILPILMGVTMFLQQKLTPAPQDqPPQMKMMMLyfMPLMFLFFF 160
|
170 180
....*....|....*....|....*..
gi 489187856 543 LWFPAGLVLYWVVNNCLSIAQQWYITR 569
Cdd:pfam02096 161 LNFPAGLVLYWVVSNLLSIGQQLIINR 187
|
|
| 5TM_YidC_Alb3 |
cd20070 |
Five transmembrane core domain of membrane protein insertase YidC, Alb3, and similar proteins; ... |
392-569 |
6.85e-102 |
|
Five transmembrane core domain of membrane protein insertase YidC, Alb3, and similar proteins; This group is composed of the bacterial and chloroplastic members of the YidC/Oxa1/Alb3 protein family of insertases, including bacterial YidC, and chloroplastic ALBINO3 (Alb3) and Alb3-like proteins such as ALBINO3-like protein 1 (also called Alb4). Membrane protein insertase YidC, also called foldase YidC or membrane integrase YidC, facilitates proper folding, insertion, and assembly of inner membrane proteins and complexes. Depending on the nature of the substrate, YidC functions in a Sec-independent (YidC only) or a Sec-dependent manner as part of a complex containing YidC, the SecYEG channel, and SecDFYajC. YidC from Gram-negative bacteria contains an extra transmembrane segment (TM1) at the N-terminus and a large periplasmic domain, located between TM1 and TM2, that adopts a beta-super sandwich fold that is found in sugar-binding proteins such as galactose mutarotase. Alb3 and Alb3-like proteins are required for the post-translational insertion of the light-harvesting chlorophyll-binding proteins (LHCPs) into the chloroplast thylakoid membrane. Alb3 acts independently and may also function cooperatively with the thylakoid cpSecYE translocase to insert proteins co-translationally into the thylakoid membrane, similar to bacterial YidC that can function with the SecYEG translocase. YidC/Oxa1/Alb3 family insertases contain a core domain of five transmembrane (5TM) segments that is essential to insertase function.
Pssm-ID: 410994 [Multi-domain] Cd Length: 181 Bit Score: 305.46 E-value: 6.85e-102
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489187856 392 GWSIIALTVLIKLAFFPLSAASYRSMARMRAVSPKMQAIKEQHGDDRQKMSQAMMELYKKEKINPLGGCLPILVQMPVFL 471
Cdd:cd20070 1 GLAIILLTILIRLLLLPLTLKQYKSMKKMQELQPKIKEIQEKYKDDKQKLQQEMMKLYKEHGVNPLGGCLPLLIQMPIFI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489187856 472 SLYWVLLESVEMRQAPWLGWITDLSVKDPFFILPIVMGGTMLIQQMLNPTPPD---PMQAKVMKLMPIIFTFFFLWFPAG 548
Cdd:cd20070 81 ALYQVLRNSIELRGAPFLWWILDLSAPDPYYILPILMGVTMFLQQKLTPTPTDdqaPQQKMMMYFMPVMFTFIFLSFPSG 160
|
170 180
....*....|....*....|.
gi 489187856 549 LVLYWVVNNCLSIAQQWYITR 569
Cdd:cd20070 161 LVLYWLVSNLFSIIQQLIINK 181
|
|
| YidC_periplas |
pfam14849 |
YidC periplasmic domain; This is the periplasmic domain of YidC, a bacterial membrane protein ... |
82-367 |
1.29e-95 |
|
YidC periplasmic domain; This is the periplasmic domain of YidC, a bacterial membrane protein which is required for the insertion and assembly of inner membrane proteins.
Pssm-ID: 464346 Cd Length: 266 Bit Score: 292.64 E-value: 1.29e-95
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489187856 82 IQVKTDVLDLAIDPRGGDIVQLGLLQYPRRLDRPDVPFPLFDNGRERTYLAQSGLTGADGPDASSAgRPLFHSAQSSYQL 161
Cdd:pfam14849 1 ITVETDVLRGSISLKGGRIDDLELKKYRETLDDDSPPVVLLSPSGGRTYVAQSGLIGAGGPDLPPH-DTVFTAEGGSYTL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489187856 162 ADGQNELVVDLSFS-HDGVNYIKRFTFHRGlkadcsdkekaqkkiecinenAYQVGVSYLIDNQSGKTWSGNLFAQLKRD 240
Cdd:pfam14849 80 ADGTDELPVTLTWDnGNGVTFTKTYTFDRG---------------------SYLIDVTYEVENTSGAPVTLQPYGQLVRD 138
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489187856 241 GSADPSSTTATgvsTYLGAAVWTPDSPYKKISTKDMDKE---QFKESVQGGWVAWLQHYFVTAWVP-TKGEQHQVMTRKD 316
Cdd:pfam14849 139 PGEPEGSSFYI---TYTGAAGSTDEGKYQKVSFDDIEKGgklKVDTTTGGGWVAMTQHYFLSAWIPdQDGTTNEFYTRFL 215
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|.
gi 489187856 317 GQGNYIVGFTGPTLSVPAGSKVETDLTLYAGPKLQKHLKELSPGLELTVDY 367
Cdd:pfam14849 216 GGNLYQAGYISPAVTVAPGASATVTARLFAGPKEQKVLEAIAPGLDLAVDY 266
|
|
| EcYidC-like_peri |
cd19961 |
periplasmic beta-super sandwich fold domain of membrane protein insertase YidC from ... |
80-367 |
5.19e-62 |
|
periplasmic beta-super sandwich fold domain of membrane protein insertase YidC from Escherichia coli and similar domains; This subfamily is composed of Escherichia coli YidC and similar proteins. Membrane protein insertase YidC, also called foldase YidC or membrane integrase YidC, facilitates proper folding, insertion, and assembly of inner membrane proteins and complexes. Depending on the nature of the substrate, YidC functions in a Sec-independent (YidC only) or a Sec-dependent manner as part of a complex containing YidC, the SecYEG channel, and SecDFYajC. YidC belongs to the YidC/Oxa1/Alb3 protein family of insertases that contain a core domain of five transmembrane (TM) segments that is essential to insertase function. In addition to this core transmembrane domain, YidC from Gram-negative bacteria contain an extra transmembrane segment (TM1) at the N-terminus and a large periplasmic domain, located between TM1 and TM2, that adopts a beta-super sandwich fold that is found in sugar-binding proteins such as galactose mutarotase. This periplasmic domain may have a role in protein assembly: a region of YidC that binds to SecF maps to one edge of the beta-super sandwich.
Pssm-ID: 411000 Cd Length: 255 Bit Score: 205.24 E-value: 5.19e-62
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489187856 80 KLIQVKTDVLDLAIDPRGGDIVQLGLLQYPRRLDrPDVPFPLFDNgrERTYLAQSGLTGADGPDASSAgRPLFHSAQSSY 159
Cdd:cd19961 1 KRITVETDLLKASISTKGGRIKSVELKKYKETLP-DSKPVELLSP--DGPYVAQLGLIGADGPLIPTA-DLLFTADSGSY 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489187856 160 qlaDGQNELVVDLSFSH-DGVNYIKRFTFHRglkadcsdkekaqkkiecineNAYQVGVSYLIDNQSGKTWSGNLFAQLK 238
Cdd:cd19961 77 ---EGGDSLTVTLTWTNgDGLTIEKTYTFDP---------------------DSYLIDVEVRVENNSSAPLSLSLYLQLQ 132
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489187856 239 RDGSADPSSTTAtgvSTYLGAAVwTPDSPYKKISTKDMDKEQFKESvQGGWVAWLQHYFVTAWVPTKGEQHQVMTRKDgQ 318
Cdd:cd19961 133 RKGGEPEGSGST---ITYEGPAG-TEDGKLEKLSFKDLEEEKLSSG-KVGWVAFKQKYFLSALIPDQGFFYSAKLSGK-D 206
|
250 260 270 280
....*....|....*....|....*....|....*....|....*....
gi 489187856 319 GNYIVGFTGPTLSVPAGSKVETDLTLYAGPKLQKHLKELSPGLELTVDY 367
Cdd:cd19961 207 DGDGVKLLSAALTLPPGGSGTFSFRLYAGPKDYDILKAYGPGLELAVDF 255
|
|
| 5TM_YidC_Oxa1_Alb3 |
cd19751 |
Five transmembrane core domain of YidC/Oxa1/Alb3 protein family of insertases; The YidC/Oxa1 ... |
392-569 |
1.40e-59 |
|
Five transmembrane core domain of YidC/Oxa1/Alb3 protein family of insertases; The YidC/Oxa1/Alb3 protein family of insertases facilitate the insertion, folding and assembly of proteins of the inner membranes of bacteria and mitochondria, and the thylakoid membrane of plastids. Members include bacterial YidC, mitochondrial Cox18 and Oxa1, and chloroplastic Alb3 and Alb4. Membrane protein insertase YidC, also called foldase YidC or membrane integrase YidC, facilitates proper folding, insertion, and assembly of inner membrane proteins and complexes. Oxa1 and Cox18/Oxa2 mediate the insertion of both mitochondrion-encoded precursors and nuclear-encoded proteins from the matrix into the mitochondrial inner membrane. Alb3 and Alb3-like proteins, including Alb4, are required for the post-translational insertion of the light-harvesting chlorophyll-binding proteins (LHCPs) into the chloroplast thylakoid membrane. YidC/Oxa1/Alb3 family insertases contain a core domain of five transmembrane (5TM) segments that is essential to insertase function.
Pssm-ID: 410992 [Multi-domain] Cd Length: 189 Bit Score: 196.24 E-value: 1.40e-59
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489187856 392 GWSIIALTVLIKLAFFPLSAASYRSMARMRAVSPKMQAIKEQHGDD------RQKMSQAMMELYKKEKINPLGGCLPILV 465
Cdd:cd19751 1 GLSIIIVTILIRLALLPLTLKQQKSMRKMQVIRPEMEAIREKYKEKaskdkvQQEMQKEMLGLYKKHGVNPMAGCLPLFI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489187856 466 QMPVFLSLYWVLLESVEMRQAPWLgWITDLSVKDPFFILPIVMGGTMLIQQMLNPT------PPDPMQAKVMKLMPIIFT 539
Cdd:cd19751 81 QLPIFMAFYFAIMRTEEIRYHTFL-WFFDLGQPDYLYILPFVAGITTYFQFKMTMShqqqmqMMQMQMKVMLYVMPVMII 159
|
170 180 190
....*....|....*....|....*....|
gi 489187856 540 FFFLWFPAGLVLYWVVNNCLSIAQQWYITR 569
Cdd:cd19751 160 IAGLSFPSALSLYWIISNLFMIIQTYFIVR 189
|
|
| PRK00145 |
PRK00145 |
putative inner membrane protein translocase component YidC; Provisional |
377-578 |
4.99e-49 |
|
putative inner membrane protein translocase component YidC; Provisional
Pssm-ID: 234665 [Multi-domain] Cd Length: 223 Bit Score: 169.54 E-value: 4.99e-49
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489187856 377 IFWLLQH-IHSLIGNWGWS----IIALTVLIKLAFFPLSAASYRSMARMRAVSPKMQAIKEQHGDDRQKMSQAMMELYKK 451
Cdd:PRK00145 12 FFKFIHGfVSSVISNPNFSygiaIILVTLIIRLLILPLNIKQTKSSLRMNEIQPEIKKLQAKYKNDPQKLQQEMMKLYKE 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489187856 452 EKINPLGGCLPILVQMPVFLSLYWVLLESVEMRQAPWLgWITDLSVKDPFFILPIVMGGTMLIQQMLNpTPPDPMQAKVM 531
Cdd:PRK00145 92 KGVNPLGGCLPLLIQWPILIALYYVFNNLTGINGVSFL-WIKDLAKPDITWILPILSGATTYLSGYLM-TKADSSQAGQM 169
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|.
gi 489187856 532 KLMPIIFTFFFLW----FPAGLVLYWVVNNCLSIAQQwYITRKIEAAAKTA 578
Cdd:PRK00145 170 KTMNIGMSIFMGVmswkFKSALVLYWVIGNLIQIIQT-YFIKKLELKKKVE 219
|
|
| PRK01001 |
PRK01001 |
putative inner membrane protein translocase component YidC; Provisional |
344-573 |
5.78e-47 |
|
putative inner membrane protein translocase component YidC; Provisional
Pssm-ID: 234887 [Multi-domain] Cd Length: 795 Bit Score: 176.14 E-value: 5.78e-47
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489187856 344 LYAGPKLQKHLKEL------SPGLelTVDY-------GFLWFIAQP----IFWLLQHIHSLIGNWGWSIIALTVLIKLAF 406
Cdd:PRK01001 514 VYAGPLADPTLKTLdraytnSKGE--NPEYldsitfrGFFSFITEPfaalLFIIMKFFKFLTGSWGISIILLTVFLKLLL 591
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489187856 407 FPLSAASYRSMARMRAVSPKMQAIKEQHGDDRQKMSQAMMELYKKEKINPLGGCLPILVQMPVFLSLYWVLLESVEMRQA 486
Cdd:PRK01001 592 YPLNAWSIRSMRRMQKLSPYIQEIQQKYKKEPKRAQMEIMALYKTNKVNPITGCLPLLIQLPFLIAMFDLLKSSFLLRGA 671
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489187856 487 PWL-GWITDLSVKDPFF--------------ILPIVMGGTMLIQQMLNPT-PPDPM-----QAKVM-KLMPIIFTFFFLW 544
Cdd:PRK01001 672 SFIpGWIDNLTAPDVLFswetpiwfignefhLLPILLGVVMFAQQKISSLkRKGPVtdqqrQQEAMgTMMALLFTFMFYN 751
|
250 260
....*....|....*....|....*....
gi 489187856 545 FPAGLVLYWVVNNCLSIAQQWYITRKIEA 573
Cdd:PRK01001 752 FPSGLNIYWLSSMLLGVIQQWVTNKILDS 780
|
|
| 5TM_Oxa1-like |
cd20069 |
Five transmembrane core domain of mitochondrial inner membrane protein Oxa1 and similar ... |
391-565 |
7.93e-46 |
|
Five transmembrane core domain of mitochondrial inner membrane protein Oxa1 and similar proteins; This group is composed mostly of the mitochondrial members of the YidC/Oxa1/Alb3 protein family of insertases, including mitochondrial inner membrane proteins Oxa1, Oxa1-like (Oxa1L), cytochrome c oxidase assembly protein 18 (Cox18, also called Oxa2), and Arabidopsis thaliana mitochondrial ALBINO3-like protein 3 (ALB33). It also includes Arabidopsis thaliana chloroplastic ALBINO3-like protein 2 (ALB32). Members of this group mediate the insertion of both mitochondrion-encoded precursors and nuclear-encoded proteins from the matrix into the mitochondrial inner membrane. Oxa1 and Cox18/Oxa2 are essential for the activity and assembly of cytochrome c oxidase, playing central roles in the translocation and export of the N-terminal and C-terminal parts, respectively, of the COX2 protein into the mitochondrial intermembrane space. ALB32 may be involved in the insertion of integral membrane proteins into the chloroplast thylakoid membranes. YidC/Oxa1/Alb3 family insertases contain a core domain of five transmembrane (5TM) segments that is essential to insertase function.
Pssm-ID: 410993 [Multi-domain] Cd Length: 201 Bit Score: 160.00 E-value: 7.93e-46
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489187856 391 WGWSIIALTVLIKLAFFPLSAASYRSMARMRAVSPKMQAIKE------QHGDD--RQKMSQAMMELYKKEKINPLGGCLP 462
Cdd:cd20069 4 WWATIAATTVALRLLLLPLVIKSQRNAARMANLQPELQKLQEklkearASGDQleAAEARKELKELMKKHNVNPLKSLLL 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489187856 463 ILVQMPVFLSLYWVL-----LESVEMRQAPwLGWITDLSVKDPFFILPIVMGGTMLI------QQMLNPTPPDPMQAKVM 531
Cdd:cd20069 84 PLVQAPVFISFFFALrkmanLPVPSFKTGG-LLWFTDLTVPDPYYILPILTSLTFLAtielgaETGTSGSPQSKTMKNVF 162
|
170 180 190
....*....|....*....|....*....|....
gi 489187856 532 KLMPIIFTFFFLWFPAGLVLYWVVNNCLSIAQQW 565
Cdd:cd20069 163 RGLPVLMIPFTANFPSAVFLYWITSNLFSLAQNL 196
|
|
| PRK02944 |
PRK02944 |
YidC family membrane integrase SpoIIIJ; |
372-568 |
6.63e-45 |
|
YidC family membrane integrase SpoIIIJ;
Pssm-ID: 179508 Cd Length: 255 Bit Score: 159.55 E-value: 6.63e-45
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489187856 372 FIAQPIFWLLQHIHSLIG-NWGWSIIALTVLIKLAFFPLSAASYRSMARMRAVSPKMQAIKEQHGDD----RQKMSQAMM 446
Cdd:PRK02944 39 YFVYPLSQLITYFANLFGsNYGLAIIVVTLLIRLLILPLMIKQTKSTKAMQALQPEMQKLKEKYSSKdqatQQKLQQEMM 118
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489187856 447 ELYKKEKINPLGGCLPILVQMPVFLSLYWVLLESVEMRQAPWLgWItDLSVKDPFFILPIVMGGTMLIQQ--MLNPTPPD 524
Cdd:PRK02944 119 QLFQKNGVNPLAGCLPIFIQMPILIAFYHAIMRTSEISKHSFL-WF-DLGQADPYYILPIVAGITTFIQQklMMAGTAGQ 196
|
170 180 190 200
....*....|....*....|....*....|....*....|....*
gi 489187856 525 PMQAKVMK-LMPIIFTFFFLWFPAGLVLYWVVNNCLSIAQQWYIT 568
Cdd:PRK02944 197 NPQMAMMLwLMPIMILIFAINFPAALSLYWVVGNIFMIAQTYLIK 241
|
|
| PRK01315 |
PRK01315 |
putative inner membrane protein translocase component YidC; Provisional |
369-569 |
1.91e-40 |
|
putative inner membrane protein translocase component YidC; Provisional
Pssm-ID: 234941 Cd Length: 329 Bit Score: 149.50 E-value: 1.91e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489187856 369 FLWFIAQPIFWLLQHI----HSLIG---------NWGWSIIALTVLIKLAFFPLSAASYRSMARMRAVSPKMQAIKEQHG 435
Cdd:PRK01315 7 FGSAIMTPLYWVISGIlvlfHTLLGflfgpdsglTWVLSIVGLVIVIRALLIPLFVKQIKSQRNMQEIQPKMKKIQEKYK 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489187856 436 DDRQKMSQAMMELYKKEKINPLGGCLPILVQMPVFLSLYWVLLESVEMRQ--APWLGWITDLSVKDPFF----------- 502
Cdd:PRK01315 87 GDRERMSQEMMKLYKETGTNPLSSCLPLLLQMPIFFALYRVLDSAASRGDgiGPINPPLLESFRHAHIFgaplaatflqa 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489187856 503 -------------ILPIVMGGTMLIQQ---MLNPTPPD----PM--QAKVM-KLMPIIFTFFFLWFPAGLVLYWVVNNCL 559
Cdd:PRK01315 167 lnagntavqvvaaVLIILMSASQFITQlqlMTKNMPPEaktgPMaqQQKMLlYLFPLMFLVSGIAFPVGVLFYWLTSNVW 246
|
250
....*....|
gi 489187856 560 SIAQQWYITR 569
Cdd:PRK01315 247 TMGQQFYVIR 256
|
|
| PRK01622 |
PRK01622 |
membrane protein insertase YidC; |
372-571 |
1.38e-34 |
|
membrane protein insertase YidC;
Pssm-ID: 179310 Cd Length: 256 Bit Score: 131.41 E-value: 1.38e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489187856 372 FIAQPIFWLLQHIHSLI-GNWGWSIIALTVLIKLAFFPLSAASYRSM----ARMRAVSPKMQAIKEQHGDDRQKMSQA-- 444
Cdd:PRK01622 40 YFVYPFSFLIQFVAHHIgGSYGIAIIIVTLIIRSLMIPLAVSQYKSQrgmqEKMAVMKPELDKIQAKLKVTKDLEKQKey 119
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489187856 445 ---MMELYKKEKINPLG-GCLPILVQMPVFLSLYWVLLESVEMRQAPWLgWItdlSVKDPFFILPIVMGGTMLIQ---QM 517
Cdd:PRK01622 120 qkeMMELYKSGNINPLAmGCLPLLIQMPILSAFYYAIRRTEEIASHSFL-WF---NLGHADHILPIIAGLTYFIQmkvSQ 195
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*.
gi 489187856 518 LNPTPPDPMQ-AKVMKLM-PIIFTFFFLWFPAGLVLYWVVNNcLSIAQQWYITRKI 571
Cdd:PRK01622 196 SNGTSPEQVQmLKIQGIMmPAMILFMSFAAPSALVLYWITGG-LFLMGQTIVLRKV 250
|
|
| PRK03449 |
PRK03449 |
putative inner membrane protein translocase component YidC; Provisional |
370-578 |
7.01e-29 |
|
putative inner membrane protein translocase component YidC; Provisional
Pssm-ID: 179580 Cd Length: 304 Bit Score: 116.70 E-value: 7.01e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489187856 370 LWFIAQPIFWLLQHIHSLIG---------NWGWSIIALTVLIKLAFFPLSAASYRSMARMRAVSPKMQAIKEQHGDDRQK 440
Cdd:PRK03449 2 LDFIYYPVSAILWFWHKLFSfvlgpdngfAWALSVMFLVFTLRALLYKPFVRQIRTTRKMQELQPQIKALQKKYGNDRQK 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489187856 441 MSQAMMELYKKEKINPLGGCLPILVQMPVFLSLYWVLLE-------------SVEMRQ---------------------- 485
Cdd:PRK03449 82 MALEMQKLQKEHGFNPILGCLPMLAQIPVFLGLFHVLRSfnrtgtgfgqlgmSVEENRntpnyvfsaedvqsfldarlfg 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489187856 486 APWLGWITD----------------LSVKDPFFILPIV---MGGTMLIQ-----QMLNPTPPdPMQAKVMKLMP--IIFT 539
Cdd:PRK03449 162 APLSAYITMprsgldafvdftrtniILVGVPLMIIAGVathFNSRASVArqsaeAAANPQTA-MMNKLALWVFPlgVLVG 240
|
250 260 270 280
....*....|....*....|....*....|....*....|..
gi 489187856 540 FFFLwfPAGLVLYWVVNNCLSIAQQWYITRKI---EAAAKTA 578
Cdd:PRK03449 241 GPFL--PLAILLYWVSNNIWTFGQQHYVFGKIdkeEEAKKQA 280
|
|
| PRK02654 |
PRK02654 |
putative inner membrane protein translocase component YidC; Provisional |
376-477 |
8.03e-27 |
|
putative inner membrane protein translocase component YidC; Provisional
Pssm-ID: 235058 Cd Length: 375 Bit Score: 112.38 E-value: 8.03e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489187856 376 PIfwlLQHIHSLIGNWGWSIIALTVLIKLAFFPLSAASYRSMARMRAVSPKMQA----IKEQHGDDRQKMSQAMMELYkK 451
Cdd:PRK02654 15 PI---LDFFYGIVPSYGLAIVALTLVIRFALYPLSAGSIRNMRRMKIAQPVMQKrqaeIQERYKNDPQKQQEEMGKLM-K 90
|
90 100
....*....|....*....|....*.
gi 489187856 452 EKINPLGGCLPILVQMPVFLSLYWVL 477
Cdd:PRK02654 91 EFGNPLAGCLPLLVQMPILFALFATL 116
|
|
| PRK02463 |
PRK02463 |
OxaA-like protein precursor; Provisional |
367-568 |
2.78e-24 |
|
OxaA-like protein precursor; Provisional
Pssm-ID: 235040 Cd Length: 307 Bit Score: 103.27 E-value: 2.78e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489187856 367 YGFLW-FIAQPIFWLLQHIHSLIG-NWGWSIIALTVLIKLAFFPLS-----AASYRSmARMRAVSPKMQAIKE---QHGD 436
Cdd:PRK02463 34 TGFIWnFLGAPMSYFIDYFANNLGlGFGLAIIIVTIIVRLIILPLGlyqswKATYQS-EKMAYLKPVFEPINErlkNATT 112
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489187856 437 DRQKMS--QAMMELYKKEKINPLG--GCLPILVQMPVFLSLYWVLLESVEMRQAPWLGwitdLSVKDPFFILPIVMGGTM 512
Cdd:PRK02463 113 QEEKMAaqTELMAAQRENGISMLGgiGCLPLLIQMPFFSALYFAAQYTKGVSTSTFLG----IDLGSPSLVLTAIIGVLY 188
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|
gi 489187856 513 LIQQMLNPTPPDPMQAKVMK----LMPIIFTFFFLWFPAGLVLYWVVNNCLSIAQQWYIT 568
Cdd:PRK02463 189 FFQSWLSMMGVPEEQREQMKammyMMPIMMVVFSFSSPAGVGLYWLVGGFFSIIQQLITT 248
|
|
| PRK02201 |
PRK02201 |
putative inner membrane protein translocase component YidC; Provisional |
364-563 |
1.94e-21 |
|
putative inner membrane protein translocase component YidC; Provisional
Pssm-ID: 235012 Cd Length: 357 Bit Score: 96.23 E-value: 1.94e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489187856 364 TVDYG-FLWFIAQPIFWLLQHIHSLIGNWGW-------SIIALTVLIKLAFFPLSAASYRSMARMRAVSPKMQAIKEQHG 435
Cdd:PRK02201 98 TWKYGpFYGLFVYPIAQIILSIMASQSLSELygwstilAIIVVVLIIRLISFLITFKSTFNQEKQEELQGKKAKIDAKYK 177
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489187856 436 DD------RQKMSQAMMELYKKEKINPLGGCLPILVQMPVFLSLYWVLLESVEMRQAPWLGwiTDLSVKD---------P 500
Cdd:PRK02201 178 DYkkdkqmKQRKQQEIQELYKKHNISPFSPFVQMFVTLPIFIAVYRVVQSLPSIKVTTWLG--IDLSATSwqeifagnwI 255
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 489187856 501 FFILPIVMGGTMLIQQML---------NPTPPDPMQAKVMK-------LMPIIFTFFFLWFPAGLVLYWVVNNCLSIAQ 563
Cdd:PRK02201 256 YLPILIIVVPVQALSQLLpqilnkkknKERTLNVKEKEALKkqnktqnIISIVFIFFGVIFAAGVQIYWIIGGIWTILQ 334
|
|
| PRK00247 |
PRK00247 |
putative inner membrane protein translocase component YidC; Validated |
391-478 |
2.29e-12 |
|
putative inner membrane protein translocase component YidC; Validated
Pssm-ID: 178945 [Multi-domain] Cd Length: 429 Bit Score: 69.11 E-value: 2.29e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489187856 391 WGWSIIALTVLIKLAFFPLSAASYRS---MARMRavsPKMQAIKEQHGD-----DRQKMSQAMMELYKKEKINPLGGCLP 462
Cdd:PRK00247 32 WFASLFGLVITVRAIIAPFTWQQYKSgrtAAHIR---PKRKALREEYKGktdeaSIRELQQKQKDLNKEYGYNPLAGCVP 108
|
90
....*....|....*.
gi 489187856 463 ILVQMPVFLSLYWVLL 478
Cdd:PRK00247 109 ALIQIPVFLGLYQVLL 124
|
|
| YidC_peri |
cd19960 |
periplasmic beta-super sandwich fold domain of membrane protein insertase YidC from ... |
80-366 |
2.70e-07 |
|
periplasmic beta-super sandwich fold domain of membrane protein insertase YidC from Gram-negative bacteria and similar domains; Membrane protein insertase YidC, also called foldase YidC or membrane integrase YidC, facilitates proper folding, insertion, and assembly of inner membrane proteins and complexes. Depending on the nature of the substrate, YidC functions in a Sec-independent (YidC only) or a Sec-dependent manner as part of a complex containing YidC, the SecYEG channel, and SecDFYajC. YidC belongs to the YidC/Oxa1/Alb3 protein family of insertases that contains a core domain of five transmembrane (TM) segments that is essential to insertase function. In addition to this core transmembrane domain, YidC from Gram-negative bacteria contain an extra transmembrane segment (TM1) at the N-terminus and a large periplasmic domain, located between TM1 and TM2, that adopts a beta-super sandwich fold that is found in sugar-binding proteins such as galactose mutarotase. This periplasmic domain may have a role in protein assembly: a region of YidC that binds to SecF maps to one edge of the beta-super sandwich. Other members of the YidC/Oxa1/Alb3 family include YidC1/YidC2 from gram-positive bacteria as well as eukaryotic members such as mitochondrial Oxa1/Oxa2 (or Cox18) and chloroplastic Alb3/Alb4; they are not part of this hierarchy as they do not possess the periplasmic domain.
Pssm-ID: 410999 Cd Length: 233 Bit Score: 51.87 E-value: 2.70e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489187856 80 KLIQVKTDVLDLAIDPRGgDIVQLGLLQYPRRLDRPDVPFpLFDNgrertyLAQSGLTGADGPDA---SSAGRPLfhSAQ 156
Cdd:cd19960 1 IIATVKSKDFELTIDTLG-RISQFYLKDKKYKNEDGKQLE-LISP------QAPKPLEIRFSDPAlneEAFKTPY--TAS 70
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489187856 157 SSyQLADGQNELVVDLSFSHDGVNYIKRFTFHRGLKADCsdkekaqkKIEcINENayqvgVSYLIDNQSgktwsgnlfaq 236
Cdd:cd19960 71 VS-EIDLESGPQSVVLTQTLSGLTVTKTITFYPDGHYDV--------KVK-LSKP-----VDYFITPGQ----------- 124
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489187856 237 lkRDGSADPSSTTAtgvstylGAAVWTPDSPYKKIstKDMDKEQFKESVQGGWVAWLQHYFVTAWVPTKGEQHQVMTrKD 316
Cdd:cd19960 125 --RPNAAVDSYTVH-------GALVKTADGTITII--EDGDAEGTESFSNVNIAASFDRYYATLFYNFDKGLNVVVT-KD 192
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|
gi 489187856 317 GQGNYIVGFtgptlsvpaGSKVETDLTLYAGPKLQKHLKELSPGLELTVD 366
Cdd:cd19960 193 ASDNPLVFV---------KGNGNFSLHGYIGPKEYKLLKSIDPELTDVIE 233
|
|
| |
