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Conserved domains on  [gi|489185546|ref|WP_003094967|]
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MULTISPECIES: hypoxanthine-guanine phosphoribosyltransferase [Pseudomonas]

Protein Classification

hypoxanthine-guanine phosphoribosyltransferase( domain architecture ID 10793154)

hypoxanthine-guanine phosphoribosyltransferase converts guanine to guanosine monophosphate, and hypoxanthine to inosine monophosphate

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PRK09162 PRK09162
hypoxanthine-guanine phosphoribosyltransferase; Provisional
 3-184 2.29e-125

hypoxanthine-guanine phosphoribosyltransferase; Provisional


:

Pssm-ID: 181675  Cd Length: 181  Bit Score: 350.32  E-value: 2.29e-125
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489185546   3 VDLAHIRQVMAEADCLFNNDEVEAAIGRVAEAINRDLGETNPVVFCVMNGGLIFSGKLLPLLDFPLELSYLHATRYRNET 82
Cdd:PRK09162   1 MSLEEIRQVLAEADCLVSAAEVEAAIDRMADEITADLADENPLVLCVMGGGLVFTGQLLPRLDFPLEFDYLHATRYRNET 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489185546  83 SGGELFWKAKPEISFIDRDVLIIDDILDEGHTLSAIIDFCKHAGARAVHTAVLVDKEHERKArPDLKASFTGLYCADRYV 162
Cdd:PRK09162  81 TGGELVWKVKPRESLKGRTVLVVDDILDEGHTLAAIRDRCLEMGAAEVYSAVLVDKTHDRKA-KPLKADFVGLEVPDRYV 159

                        170       180
                 ....*....|....*....|..
gi 489185546 163 FGYGMDYKGYWRNAAGIFAVKG 184
Cdd:PRK09162 160 FGYGMDYKGYWRNLPGIYAVKG 181
 
Name Accession Description Interval E-value
PRK09162 PRK09162
hypoxanthine-guanine phosphoribosyltransferase; Provisional
 3-184 2.29e-125

hypoxanthine-guanine phosphoribosyltransferase; Provisional


Pssm-ID: 181675  Cd Length: 181  Bit Score: 350.32  E-value: 2.29e-125
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489185546   3 VDLAHIRQVMAEADCLFNNDEVEAAIGRVAEAINRDLGETNPVVFCVMNGGLIFSGKLLPLLDFPLELSYLHATRYRNET 82
Cdd:PRK09162   1 MSLEEIRQVLAEADCLVSAAEVEAAIDRMADEITADLADENPLVLCVMGGGLVFTGQLLPRLDFPLEFDYLHATRYRNET 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489185546  83 SGGELFWKAKPEISFIDRDVLIIDDILDEGHTLSAIIDFCKHAGARAVHTAVLVDKEHERKArPDLKASFTGLYCADRYV 162
Cdd:PRK09162  81 TGGELVWKVKPRESLKGRTVLVVDDILDEGHTLAAIRDRCLEMGAAEVYSAVLVDKTHDRKA-KPLKADFVGLEVPDRYV 159

                        170       180
                 ....*....|....*....|..
gi 489185546 163 FGYGMDYKGYWRNAAGIFAVKG 184
Cdd:PRK09162 160 FGYGMDYKGYWRNLPGIYAVKG 181
HptA COG0634
Hypoxanthine-guanine phosphoribosyltransferase [Nucleotide transport and metabolism]; ...
 13-183 2.22e-74

Hypoxanthine-guanine phosphoribosyltransferase [Nucleotide transport and metabolism]; Hypoxanthine-guanine phosphoribosyltransferase is part of the Pathway/BioSystem: Purine salvage


Pssm-ID: 440399  Cd Length: 176  Bit Score: 221.05  E-value: 2.22e-74
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489185546  13 AEADCLFNNDEVEAAIGRVAEAINRDLGETNPVVFCVMNGGLIFSGKLLPLLDFPLELSYLHATRYRNETSG-GELFWKA 91
Cdd:COG0634    4 DIAEVLISEEEIQARVKELAAQITADYAGKEPLVVGVLKGAFVFMADLLRALDFPLEIDFMHVSSYGGGTESsGEVRILK 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489185546  92 KPEISFIDRDVLIIDDILDEGHTLSAIIDFCKHAGARAVHTAVLVDKEHERKarPDLKASFTGLYCADRYVFGYGMDYKG 171
Cdd:COG0634   84 DLDEDIEGRDVLIVEDIIDTGLTLSYLLELLKSRGPASVKIATLLDKPERRK--VDVPADYVGFEIPDEFVVGYGLDYAE 161

                        170
                 ....*....|..
gi 489185546 172 YWRNAAGIFAVK 183
Cdd:COG0634  162 YYRNLPYIYALK 173
HGPRTase TIGR01203
hypoxanthine phosphoribosyltransferase; Alternate name: hypoxanthine-guanine ...
 18-175 1.02e-30

hypoxanthine phosphoribosyltransferase; Alternate name: hypoxanthine-guanine phosphoribosyltransferase. Sequence differences as small as a single residue can affect whether members of this family act on hypoxanthine and guanine or hypoxanthine only. The designation of this model as equivalog reflects hypoxanthine specificity and does not reflect whether or not guanine can replace hypoxanthine. [Purines, pyrimidines, nucleosides, and nucleotides, Salvage of nucleosides and nucleotides]


Pssm-ID: 273497  Cd Length: 166  Bit Score: 109.64  E-value: 1.02e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489185546   18 LFNNDEVEAAIGRVAEAINRDLGETNPVVFCVMNGGLIFSGKLLPLLDFPLELSYLHATRYRNET-SGGELFWKAKPEIS 96
Cdd:TIGR01203   2 LIPEEQIKARIAELAKQITEDYAGKPLVLLCVLKGSFPFFADLIRYIAVPVQVDFMAVSSYGNGMqSSGDVKILKDLDLD 81

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 489185546   97 FIDRDVLIIDDILDEGHTLSAIIDFCKHAGARAVHTAVLVDKEHERKArpDLKASFTGLYCADRYVFGYGMDYKGYWRN 175
Cdd:TIGR01203  82 IKGKDVLIVEDIVDTGLTLQYLLDLLKARKPKSLKIVTLLDKPSRRKV--DVKVDFVGFEIPDKFVVGYGLDYAERYRN 158
Pribosyltran pfam00156
Phosphoribosyl transferase domain; This family includes a range of diverse phosphoribosyl ...
 18-170 6.41e-23

Phosphoribosyl transferase domain; This family includes a range of diverse phosphoribosyl transferase enzymes. This family includes: Adenine phosphoribosyl-transferase EC:2.4.2.7. Hypoxanthine-guanine-xanthine phosphoribosyl-transferase. Hypoxanthine phosphoribosyl-transferase EC:2.4.2.8. Ribose-phosphate pyrophosphokinase i EC:2.7.6.1. Amidophosphoribosyltransferase EC:2.4.2.14. Orotate phosphoribosyl-transferase EC:2.4.2.10. Uracil phosphoribosyl-transferase EC:2.4.2.9. Xanthine-guanine phosphoribosyl-transferase EC:2.4.2.22. In Arabidopsis, At the very N-terminus of this domain is the P-Loop NTPase domain.


Pssm-ID: 425489 [Multi-domain]  Cd Length: 150  Bit Score: 88.96  E-value: 6.41e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489185546   18 LFNNDEVEAAIGRVAEAINRDLGETNPVVFCVMNGGLIFSGKLLPLLDFPLelSYLHATRYRNETSGGELFWKAKPEISf 97
Cdd:pfam00156   5 ILDNPAILKAVARLAAQINEDYGGKPDVVVGILRGGLPFAGILARRLDVPL--AFVRKVSYNPDTSEVMKTSSALPDLK- 81

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 489185546   98 iDRDVLIIDDILDEGHTLSAIIDFCKHAGARAVHTAVLVDKeHERKARPDlkASFTGLYCADRYVFGYGMDYK 170
Cdd:pfam00156  82 -GKTVLIVDDILDTGGTLLKVLELLKNVGPKEVKIAVLIDK-PAGTEPKD--KYDKRVDDWIVFVVGFGLDER 150
PRTases_typeI cd06223
Phosphoribosyl transferase (PRT)-type I domain; Phosphoribosyl transferase (PRT) domain. The ...
 27-143 7.09e-19

Phosphoribosyl transferase (PRT)-type I domain; Phosphoribosyl transferase (PRT) domain. The type I PRTases are identified by a conserved PRPP binding motif which features two adjacent acidic residues surrounded by one or more hydrophobic residue. PRTases catalyze the displacement of the alpha-1'-pyrophosphate of 5-phosphoribosyl-alpha1-pyrophosphate (PRPP) by a nitrogen-containing nucleophile. The reaction products are an alpha-1 substituted ribose-5'-phosphate and a free pyrophosphate (PP). PRPP, an activated form of ribose-5-phosphate, is a key metabolite connecting nucleotide synthesis and salvage pathways. The type I PRTase family includes a range of diverse phosphoribosyl transferase enzymes and regulatory proteins of the nucleotide synthesis and salvage pathways, including adenine phosphoribosyltransferase EC:2.4.2.7., hypoxanthine-guanine-xanthine phosphoribosyltransferase, hypoxanthine phosphoribosyltransferase EC:2.4.2.8., ribose-phosphate pyrophosphokinase EC:2.7.6.1., amidophosphoribosyltransferase EC:2.4.2.14., orotate phosphoribosyltransferase EC:2.4.2.10., uracil phosphoribosyltransferase EC:2.4.2.9., and xanthine-guanine phosphoribosyltransferase EC:2.4.2.22.


Pssm-ID: 206754 [Multi-domain]  Cd Length: 130  Bit Score: 78.21  E-value: 7.09e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489185546  27 AIGRVAEAINRDLGEtNPVVFCVMNGGLIFSGKLLPLLDFPLElsYLHATRYRNETSGGELFWKAKPEISFI-DRDVLII 105
Cdd:cd06223    1 AGRLLAEEIREDLLE-PDVVVGILRGGLPLAAALARALGLPLA--FIRKERKGPGRTPSEPYGLELPLGGDVkGKRVLLV 77

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 489185546 106 DDILDEGHTLSAIIDFCKHAGARAVHTAVLVDKEHERK 143
Cdd:cd06223   78 DDVIATGGTLLAAIELLKEAGAKVVGVAVLLDKPEGGA 115
 
Name Accession Description Interval E-value
PRK09162 PRK09162
hypoxanthine-guanine phosphoribosyltransferase; Provisional
 3-184 2.29e-125

hypoxanthine-guanine phosphoribosyltransferase; Provisional


Pssm-ID: 181675  Cd Length: 181  Bit Score: 350.32  E-value: 2.29e-125
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489185546   3 VDLAHIRQVMAEADCLFNNDEVEAAIGRVAEAINRDLGETNPVVFCVMNGGLIFSGKLLPLLDFPLELSYLHATRYRNET 82
Cdd:PRK09162   1 MSLEEIRQVLAEADCLVSAAEVEAAIDRMADEITADLADENPLVLCVMGGGLVFTGQLLPRLDFPLEFDYLHATRYRNET 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489185546  83 SGGELFWKAKPEISFIDRDVLIIDDILDEGHTLSAIIDFCKHAGARAVHTAVLVDKEHERKArPDLKASFTGLYCADRYV 162
Cdd:PRK09162  81 TGGELVWKVKPRESLKGRTVLVVDDILDEGHTLAAIRDRCLEMGAAEVYSAVLVDKTHDRKA-KPLKADFVGLEVPDRYV 159

                        170       180
                 ....*....|....*....|..
gi 489185546 163 FGYGMDYKGYWRNAAGIFAVKG 184
Cdd:PRK09162 160 FGYGMDYKGYWRNLPGIYAVKG 181
HptA COG0634
Hypoxanthine-guanine phosphoribosyltransferase [Nucleotide transport and metabolism]; ...
 13-183 2.22e-74

Hypoxanthine-guanine phosphoribosyltransferase [Nucleotide transport and metabolism]; Hypoxanthine-guanine phosphoribosyltransferase is part of the Pathway/BioSystem: Purine salvage


Pssm-ID: 440399  Cd Length: 176  Bit Score: 221.05  E-value: 2.22e-74
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489185546  13 AEADCLFNNDEVEAAIGRVAEAINRDLGETNPVVFCVMNGGLIFSGKLLPLLDFPLELSYLHATRYRNETSG-GELFWKA 91
Cdd:COG0634    4 DIAEVLISEEEIQARVKELAAQITADYAGKEPLVVGVLKGAFVFMADLLRALDFPLEIDFMHVSSYGGGTESsGEVRILK 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489185546  92 KPEISFIDRDVLIIDDILDEGHTLSAIIDFCKHAGARAVHTAVLVDKEHERKarPDLKASFTGLYCADRYVFGYGMDYKG 171
Cdd:COG0634   84 DLDEDIEGRDVLIVEDIIDTGLTLSYLLELLKSRGPASVKIATLLDKPERRK--VDVPADYVGFEIPDEFVVGYGLDYAE 161

                        170
                 ....*....|..
gi 489185546 172 YWRNAAGIFAVK 183
Cdd:COG0634  162 YYRNLPYIYALK 173
HGPRTase TIGR01203
hypoxanthine phosphoribosyltransferase; Alternate name: hypoxanthine-guanine ...
 18-175 1.02e-30

hypoxanthine phosphoribosyltransferase; Alternate name: hypoxanthine-guanine phosphoribosyltransferase. Sequence differences as small as a single residue can affect whether members of this family act on hypoxanthine and guanine or hypoxanthine only. The designation of this model as equivalog reflects hypoxanthine specificity and does not reflect whether or not guanine can replace hypoxanthine. [Purines, pyrimidines, nucleosides, and nucleotides, Salvage of nucleosides and nucleotides]


Pssm-ID: 273497  Cd Length: 166  Bit Score: 109.64  E-value: 1.02e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489185546   18 LFNNDEVEAAIGRVAEAINRDLGETNPVVFCVMNGGLIFSGKLLPLLDFPLELSYLHATRYRNET-SGGELFWKAKPEIS 96
Cdd:TIGR01203   2 LIPEEQIKARIAELAKQITEDYAGKPLVLLCVLKGSFPFFADLIRYIAVPVQVDFMAVSSYGNGMqSSGDVKILKDLDLD 81

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 489185546   97 FIDRDVLIIDDILDEGHTLSAIIDFCKHAGARAVHTAVLVDKEHERKArpDLKASFTGLYCADRYVFGYGMDYKGYWRN 175
Cdd:TIGR01203  82 IKGKDVLIVEDIVDTGLTLQYLLDLLKARKPKSLKIVTLLDKPSRRKV--DVKVDFVGFEIPDKFVVGYGLDYAERYRN 158
PLN02238 PLN02238
hypoxanthine phosphoribosyltransferase
 7-184 2.64e-26

hypoxanthine phosphoribosyltransferase


Pssm-ID: 215132  Cd Length: 189  Bit Score: 98.96  E-value: 2.64e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489185546   7 HIRQVmaeadcLFNNDEVEAAIGRVAEAINRDLGETNPVVFCVMNGGLIFSGKLLPLLDF---PLELSYLHATRYRNETS 83
Cdd:PLN02238   6 DIEKV------LWTAEDISARVAELAAQIASDYAGKSPVVLGVATGAFMFLADLVRAIQPlprGLTVDFIRASSYGGGTE 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489185546  84 GgelfwKAKPEISFID-------RDVLIIDDILDEGHTLSAIIDFCKHAGARAVHTAVLVDKEHERKA---RPDLKASFT 153
Cdd:PLN02238  80 S-----SGVAKVSGADlkidvkgKHVLLVEDIVDTGNTLSALVAHLEAKGAASVSVCALLDKRARRKVkyeLVGDGKEYV 154

                        170       180       190
                 ....*....|....*....|....*....|.
gi 489185546 154 GLYCADRYVFGYGMDYKGYWRNAAGIFAVKG 184
Cdd:PLN02238 155 GFECPDEFVVGYGLDFAEKYRNLPYVGVLKP 185
Pribosyltran pfam00156
Phosphoribosyl transferase domain; This family includes a range of diverse phosphoribosyl ...
 18-170 6.41e-23

Phosphoribosyl transferase domain; This family includes a range of diverse phosphoribosyl transferase enzymes. This family includes: Adenine phosphoribosyl-transferase EC:2.4.2.7. Hypoxanthine-guanine-xanthine phosphoribosyl-transferase. Hypoxanthine phosphoribosyl-transferase EC:2.4.2.8. Ribose-phosphate pyrophosphokinase i EC:2.7.6.1. Amidophosphoribosyltransferase EC:2.4.2.14. Orotate phosphoribosyl-transferase EC:2.4.2.10. Uracil phosphoribosyl-transferase EC:2.4.2.9. Xanthine-guanine phosphoribosyl-transferase EC:2.4.2.22. In Arabidopsis, At the very N-terminus of this domain is the P-Loop NTPase domain.


Pssm-ID: 425489 [Multi-domain]  Cd Length: 150  Bit Score: 88.96  E-value: 6.41e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489185546   18 LFNNDEVEAAIGRVAEAINRDLGETNPVVFCVMNGGLIFSGKLLPLLDFPLelSYLHATRYRNETSGGELFWKAKPEISf 97
Cdd:pfam00156   5 ILDNPAILKAVARLAAQINEDYGGKPDVVVGILRGGLPFAGILARRLDVPL--AFVRKVSYNPDTSEVMKTSSALPDLK- 81

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 489185546   98 iDRDVLIIDDILDEGHTLSAIIDFCKHAGARAVHTAVLVDKeHERKARPDlkASFTGLYCADRYVFGYGMDYK 170
Cdd:pfam00156  82 -GKTVLIVDDILDTGGTLLKVLELLKNVGPKEVKIAVLIDK-PAGTEPKD--KYDKRVDDWIVFVVGFGLDER 150
PRTases_typeI cd06223
Phosphoribosyl transferase (PRT)-type I domain; Phosphoribosyl transferase (PRT) domain. The ...
 27-143 7.09e-19

Phosphoribosyl transferase (PRT)-type I domain; Phosphoribosyl transferase (PRT) domain. The type I PRTases are identified by a conserved PRPP binding motif which features two adjacent acidic residues surrounded by one or more hydrophobic residue. PRTases catalyze the displacement of the alpha-1'-pyrophosphate of 5-phosphoribosyl-alpha1-pyrophosphate (PRPP) by a nitrogen-containing nucleophile. The reaction products are an alpha-1 substituted ribose-5'-phosphate and a free pyrophosphate (PP). PRPP, an activated form of ribose-5-phosphate, is a key metabolite connecting nucleotide synthesis and salvage pathways. The type I PRTase family includes a range of diverse phosphoribosyl transferase enzymes and regulatory proteins of the nucleotide synthesis and salvage pathways, including adenine phosphoribosyltransferase EC:2.4.2.7., hypoxanthine-guanine-xanthine phosphoribosyltransferase, hypoxanthine phosphoribosyltransferase EC:2.4.2.8., ribose-phosphate pyrophosphokinase EC:2.7.6.1., amidophosphoribosyltransferase EC:2.4.2.14., orotate phosphoribosyltransferase EC:2.4.2.10., uracil phosphoribosyltransferase EC:2.4.2.9., and xanthine-guanine phosphoribosyltransferase EC:2.4.2.22.


Pssm-ID: 206754 [Multi-domain]  Cd Length: 130  Bit Score: 78.21  E-value: 7.09e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489185546  27 AIGRVAEAINRDLGEtNPVVFCVMNGGLIFSGKLLPLLDFPLElsYLHATRYRNETSGGELFWKAKPEISFI-DRDVLII 105
Cdd:cd06223    1 AGRLLAEEIREDLLE-PDVVVGILRGGLPLAAALARALGLPLA--FIRKERKGPGRTPSEPYGLELPLGGDVkGKRVLLV 77

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 489185546 106 DDILDEGHTLSAIIDFCKHAGARAVHTAVLVDKEHERK 143
Cdd:cd06223   78 DDVIATGGTLLAAIELLKEAGAKVVGVAVLLDKPEGGA 115
Hpt1 COG2236
Hypoxanthine phosphoribosyltransferase [Coenzyme transport and metabolism]; Hypoxanthine ...
 12-147 9.70e-15

Hypoxanthine phosphoribosyltransferase [Coenzyme transport and metabolism]; Hypoxanthine phosphoribosyltransferase is part of the Pathway/BioSystem: Purine salvage


Pssm-ID: 441837 [Multi-domain]  Cd Length: 153  Bit Score: 67.95  E-value: 9.70e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489185546  12 MAEADCLF-NNDEVEAAIGRVAEAINRDlgETNP-VVFCVMNGGLIFSGKLLPLLDFPlELSYLHATRYRN-ETSGGELF 88
Cdd:COG2236    1 MDKFKKEYlSWDEIHELSRRLAEQILES--GFRPdVIVAIARGGLVPARILADALGVP-DLASIRVSSYTGtAKRLEEPV 77

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 489185546  89 WKAKPEISFIDRDVLIIDDILDEGHTLSAIIDFCKHAGARAVHTAVLVDKEHeRKARPD 147
Cdd:COG2236   78 VKGPLDEDLAGKRVLIVDDVADTGRTLEAVRDLLKEAGPAEVRTAVLYYKPS-SKFKPD 135
PTZ00271 PTZ00271
hypoxanthine-guanine phosphoribosyltransferase; Provisional
 9-183 2.05e-14

hypoxanthine-guanine phosphoribosyltransferase; Provisional


Pssm-ID: 140297  Cd Length: 211  Bit Score: 68.51  E-value: 2.05e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489185546   9 RQVMAEADCLFNNDEVEAAIGRVAEAINRD-----LGETNPV-VFCVMNGGLIFSGKLLPLL---DFPLELSYLHATRYR 79
Cdd:PTZ00271  18 RNYPMSAHTLVTQEQVWAATAKCAKKIAEDyrsfkLTTENPLyLLCVLKGSFIFTADLARFLadeGVPVKVEFICASSYG 97

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489185546  80 N--ETSGG-ELFWKAKPEISfiDRDVLIIDDILDEGHTLSAIIDFCKHAGARAVHTAVLVDKEHERKARpdLKASFTGLY 156
Cdd:PTZ00271  98 TgvETSGQvRMLLDVRDSVE--NRHILIVEDIVDSAITLQYLMRFMLAKKPASLKTVVLLDKPSGRKVE--VLVDYPVIT 173

                        170       180
                 ....*....|....*....|....*..
gi 489185546 157 CADRYVFGYGMDYKGYWRNAAGIFAVK 183
Cdd:PTZ00271 174 IPHAFVIGYGMDYAESYRELRDICVLK 200
PTZ00149 PTZ00149
hypoxanthine phosphoribosyltransferase; Provisional
 28-175 1.35e-12

hypoxanthine phosphoribosyltransferase; Provisional


Pssm-ID: 240293  Cd Length: 241  Bit Score: 63.63  E-value: 1.35e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489185546  28 IGRVAEAINRDLGETNPVVFCVMNGGLIFSGKLLPLLDF-----PLELS-------YLHATRYRNETSGGELFWKAKPEI 95
Cdd:PTZ00149  67 VEKLAYDIKQVYGNEELHILCILKGSRGFFSALVDYLNRihnysSTESPkppyqehYVRVKSYCNDESTGKLEIVSDDLS 146

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489185546  96 SFIDRDVLIIDDILDEGHTLSAIIDFCKHAGARAVHTAVLVDKEHERKArpDLKASFTGLYCADRYVFGYGMDYKGYWRN 175
Cdd:PTZ00149 147 CLKDKHVLIVEDIIDTGNTLVKFCEYLKKFEPKTIRIATLFEKRTPLSN--GFKGDFVGFSIPDHFVVGYCLDYNEHFRD 224
PRK15423 PRK15423
hypoxanthine phosphoribosyltransferase; Provisional
 23-175 3.09e-10

hypoxanthine phosphoribosyltransferase; Provisional


Pssm-ID: 185321  Cd Length: 178  Bit Score: 56.56  E-value: 3.09e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489185546  23 EVEAAIGRVAEAIN---RDLGeTNPVVFCVMNGGLIFSGKLLPLLDFPLELSYLHATRY---RNETSGGELFWKAKPEIS 96
Cdd:PRK15423  13 EIKARIAELGRQITeryKDSG-SDMVLVGLLRGSFMFMADLCREVQVSHEVDFMTASSYgsgMSTTRDVKILKDLDEDIR 91

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 489185546  97 fiDRDVLIIDDILDEGHTLSAIIDFCKHAGARAVHTAVLVDKEHERKArpDLKASFTGLYCADRYVFGYGMDYKGYWRN 175
Cdd:PRK15423  92 --GKDVLIVEDIIDSGNTLSKVREILSLREPKSLAICTLLDKPSRREV--NVPVEFIGFSIPDEFVVGYGIDYAQRYRH 166
PRK02277 PRK02277
orotate phosphoribosyltransferase-like protein; Provisional
 99-138 5.88e-05

orotate phosphoribosyltransferase-like protein; Provisional


Pssm-ID: 235023 [Multi-domain]  Cd Length: 200  Bit Score: 41.78  E-value: 5.88e-05
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 489185546  99 DRDVLIIDDILDEGHTLSAIIDFCKHAGARAVHTAVLVDK 138
Cdd:PRK02277 140 GKRCVIVDDVITSGTTMKETIEYLKEHGGKPVAVVVLIDK 179
PrsA COG0462
Phosphoribosylpyrophosphate synthetase [Nucleotide transport and metabolism]; ...
 99-149 7.85e-05

Phosphoribosylpyrophosphate synthetase [Nucleotide transport and metabolism]; Phosphoribosylpyrophosphate synthetase is part of the Pathway/BioSystem: Histidine biosynthesis, Purine biosynthesis


Pssm-ID: 440230 [Multi-domain]  Cd Length: 311  Bit Score: 41.97  E-value: 7.85e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 489185546  99 DRDVLIIDDILDEGHTLSAIIDFCKHAGARAVH---T-AVLVDKEHERKARPDLK 149
Cdd:COG0462  211 GKTCIIVDDMIDTGGTLVEAAEALKEAGAKSVYaaaThGVLSGPAVERLENSPID 265
PRK02304 PRK02304
adenine phosphoribosyltransferase; Provisional
 99-149 2.14e-04

adenine phosphoribosyltransferase; Provisional


Pssm-ID: 235028  Cd Length: 175  Bit Score: 40.06  E-value: 2.14e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|.
gi 489185546  99 DRdVLIIDDILDEGHTLSAIIDFCKHAGARAVHTAVLVDKEhERKARPDLK 149
Cdd:PRK02304 115 DR-VLIVDDLLATGGTLEAAIKLLERLGAEVVGAAFVIELP-DLGGREKLE 163
PRK00934 PRK00934
ribose-phosphate pyrophosphokinase; Provisional
 27-133 2.87e-04

ribose-phosphate pyrophosphokinase; Provisional


Pssm-ID: 234868 [Multi-domain]  Cd Length: 285  Bit Score: 40.28  E-value: 2.87e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489185546  27 AIGRVAEAINRDLGetNPVVFCVMNGGLIFSGKLLPLLDfpLELSYLHATRYrnetSGGELFWKAKpEISFIDRDVLIID 106
Cdd:PRK00934 141 AAPLIAEYIGDKLD--DPLVLAPDKGALELAKEAAEILG--CEYDYLEKTRI----SPTEVEIAPK-NLDVKGKDVLIVD 211

                         90       100
                 ....*....|....*....|....*..
gi 489185546 107 DILDEGHTLSAIIDFCKHAGARAVHTA 133
Cdd:PRK00934 212 DIISTGGTMATAIKILKEQGAKKVYVA 238
Apt COG0503
Adenine/guanine phosphoribosyltransferase or related PRPP-binding protein [Nucleotide ...
 102-138 4.24e-04

Adenine/guanine phosphoribosyltransferase or related PRPP-binding protein [Nucleotide transport and metabolism]; Adenine/guanine phosphoribosyltransferase or related PRPP-binding protein is part of the Pathway/BioSystem: Purine salvage


Pssm-ID: 440269  Cd Length: 171  Bit Score: 39.29  E-value: 4.24e-04
                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 489185546 102 VLIIDDILDEGHTLSAIIDFCKHAGARAVHTAVLVDK 138
Cdd:COG0503  115 VLIVDDLLATGGTAKAAIKLVEEAGAEVVGIAFLIEL 151
PyrR COG2065
Pyrimidine operon attenuation protein PyrR/uracil phosphoribosyltransferase [Nucleotide ...
 17-140 1.12e-03

Pyrimidine operon attenuation protein PyrR/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Pyrimidine operon attenuation protein PyrR/uracil phosphoribosyltransferase is part of the Pathway/BioSystem: Pyrimidine salvage


Pssm-ID: 441668  Cd Length: 178  Bit Score: 38.11  E-value: 1.12e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489185546  17 CLFNNDEVEAAIGRVA-EAINRDLGETNPVVFCVMNGGLIFS----GKLLPLLDFPLELSYLHATRYRNE-TSGGELFWK 90
Cdd:COG2065    5 EILDAADIDRALTRIAhEIIERNKGLEDLVLVGIQTRGVPLAerlaERIEEIEGVKVPVGSLDITLYRDDlRRRPPRPVV 84

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 489185546  91 AKPEISFI--DRDVLIIDDILDEGHT----LSAIIDFckhAGARAVHTAVLVDKEH 140
Cdd:COG2065   85 NETEIPFDidGKTVVLVDDVLYTGRTvraaLDALMDF---GRPAKIQLAVLVDRGH 137
PRK08558 PRK08558
adenine phosphoribosyltransferase; Provisional
 96-136 1.15e-03

adenine phosphoribosyltransferase; Provisional


Pssm-ID: 181466 [Multi-domain]  Cd Length: 238  Bit Score: 38.43  E-value: 1.15e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|...
gi 489185546  96 SFIDRD--VLIIDDILDEGHTLSAIIDFCKHAGARAVHTAVLV 136
Cdd:PRK08558 171 SALKKGdrVLIVDDIIRSGETQRALLDLARQAGADVVGVFFLI 213
ComFC COG1040
DNA utilization protein ComFC/GntX, contains phosphoribosyltransferase domain [General ...
 90-135 2.78e-03

DNA utilization protein ComFC/GntX, contains phosphoribosyltransferase domain [General function prediction only];


Pssm-ID: 440662 [Multi-domain]  Cd Length: 196  Bit Score: 37.11  E-value: 2.78e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*.
gi 489185546  90 KAKPEISFIDRDVLIIDDILDEGHTLSAIIDFCKHAGARAVHTAVL 135
Cdd:COG1040  146 AVRPPARLAGKHVLLVDDVLTTGATLAEAARALKAAGAARVDVLVL 191
PLN02440 PLN02440
amidophosphoribosyltransferase
 100-134 3.21e-03

amidophosphoribosyltransferase


Pssm-ID: 215241 [Multi-domain]  Cd Length: 479  Bit Score: 37.35  E-value: 3.21e-03
                         10        20        30
                 ....*....|....*....|....*....|....*
gi 489185546 100 RDVLIIDDILDEGHTLSAIIDFCKHAGARAVHTAV 134
Cdd:PLN02440 341 KRVVVVDDSIVRGTTSSKIVRMLREAGAKEVHMRI 375
upp PRK00129
uracil phosphoribosyltransferase; Reviewed
 78-172 3.31e-03

uracil phosphoribosyltransferase; Reviewed


Pssm-ID: 234653  Cd Length: 209  Bit Score: 36.99  E-value: 3.31e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489185546  78 YRNETSGG--ELFWKAKPEISfiDRDVLIIDDILDEGHTLSAIIDFCKHAGARAVHTAVLVDK----EHERKARPDLKas 151
Cdd:PRK00129 103 YRDEETLEpvEYYVKLPEDID--ERTVIVVDPMLATGGSAIAAIDLLKKRGAKNIKVLCLVAApegiKALEEAHPDVE-- 178

                         90       100
                 ....*....|....*....|...
gi 489185546 152 ftgLYCA--DRyvfgyGMDYKGY 172
Cdd:PRK00129 179 ---IYTAaiDE-----KLNEHGY 193
PRK09219 PRK09219
xanthine phosphoribosyltransferase; Validated
 97-138 9.69e-03

xanthine phosphoribosyltransferase; Validated


Pssm-ID: 181705  Cd Length: 189  Bit Score: 35.53  E-value: 9.69e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....
gi 489185546  97 FIDRD--VLIIDDILDEGHTLSAIIDFCKHAGARAVHTAVLVDK 138
Cdd:PRK09219 113 FLSEGdrVLIIDDFLANGQAALGLIDIIEQAGAKVAGIGIVIEK 156
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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