|
Name |
Accession |
Description |
Interval |
E-value |
| PRK10604 |
PRK10604 |
sensor protein RstB; Provisional |
86-424 |
3.48e-93 |
|
sensor protein RstB; Provisional
Pssm-ID: 236724 [Multi-domain] Cd Length: 433 Bit Score: 287.66 E-value: 3.48e-93
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489178403 86 KLTQEEQALLDKNLLVVREDFTEFISRIDAGPQLLDIKlpPEPSL-----TPLFTVLAYILLGVLVGIALLVWVRPHWRD 160
Cdd:PRK10604 86 HLDPASQQRLREGEIVALDDQYTFLQRIPRSHYVLAVG--PVPYLyylhqMRLLDIALLALIGLSLAFPVFLWMRPHWQD 163
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489178403 161 LETLRLAAQRFGDGDLSSRTRIFRRSDIRTLAQHFNQMADRIESLISNQRELTNAVSHELRTPISRLSFELEQLNKQVDA 240
Cdd:PRK10604 164 MLKLEAAAQRLGDGHLAERIHFDEGSSLERLGVAFNQMADNINALIASKKQLIDGIAHELRTPLVRLRYRLEMSDNLSAA 243
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489178403 241 EVrhdliEDMRADLGELEEMVSELLTYARLEHGNVGSHREIVDAASWLDSVVADVALEAEAAGVTCEISAcQVEQIRIEP 320
Cdd:PRK10604 244 ES-----QALNRDIGQLEALIEELLTYARLDRPQNELHLSEPDLPAWLSTHLADIQAVTPEKTVRLDTPH-QGDYGALDM 317
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489178403 321 RFMARAVINLLRNAIRHAHSRVEIALLDQGDSCQIRVNDDGPGIPADARQKIFEPFSRLDDSRDRSTGGFGLGLAIVRRV 400
Cdd:PRK10604 318 RLMERVLDNLLNNALRYAHSRVRVSLLLDGNQACLIVEDDGPGIPPEERERVFEPFVRLDPSRDRATGGCGLGLAIVHSI 397
|
330 340
....*....|....*....|....
gi 489178403 401 AQWHGGYAEALETPQGGASFRLTW 424
Cdd:PRK10604 398 ALAMGGSVNCDESELGGARFSFSW 421
|
|
| HATPase_RstB-like |
cd16939 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
323-426 |
6.09e-58 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Salmonella typhimurium RstB; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Salmonella typhimurium RstB HK of the RstA-RstB two-component regulatory system (TCS), which regulates expression of the constituents participating in pyrimidine metabolism and iron acquisition, and may be required for regulation of Salmonella motility and invasion. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensor domain.
Pssm-ID: 340416 [Multi-domain] Cd Length: 104 Bit Score: 185.33 E-value: 6.09e-58
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489178403 323 MARAVINLLRNAIRHAHSRVEIALLDQGDSCQIRVNDDGPGIPADARQKIFEPFSRLDDSRDRSTGGFGLGLAIVRRVAQ 402
Cdd:cd16939 1 MARALDNLLRNALRYAHRTVRIALLVSGGRLTLIVEDDGPGIPAAARERVFEPFVRLDPSRDRATGGFGLGLAIVHRVAL 80
|
90 100
....*....|....*....|....
gi 489178403 403 WHGGYAEALETPQGGASFRLTWER 426
Cdd:cd16939 81 WHGGHVECDDSELGGACFRLTWPR 104
|
|
| WalK |
COG5002 |
Sensor histidine kinase WalK [Signal transduction mechanisms]; |
75-423 |
1.53e-57 |
|
Sensor histidine kinase WalK [Signal transduction mechanisms];
Pssm-ID: 444026 [Multi-domain] Cd Length: 390 Bit Score: 194.00 E-value: 1.53e-57
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489178403 75 LELSLTDARQAKLTQEEQALLDKNLLVVREDFTEFISRIDAGPQLLDIKLPPEPSLTPLFTVLAYILLGVLVGIALLVWV 154
Cdd:COG5002 31 LLLLLLLLLLLLLLLLLLLLLLALLLLLLLLLLLLLALLLLLLLLLLLLALALLLLALLLLLLLLLLLLALLILLLLLAL 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489178403 155 RPHWRDLETLRLAAQRFGDGDLSSRTRIFRRSDIRTLAQHFNQMADRIESLISNQRELTNAVSHELRTPISRLSFELEQL 234
Cdd:COG5002 111 LILLAALLLLLSELLLLLLLLGRLSLRLSALLLGLLLLAAVERDITELERLEQMRREFVANVSHELRTPLTSIRGYLELL 190
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489178403 235 NKQV--DAEVRHDLIEDMRADLGELEEMVSELLTYARLEHGNVGSHREIVDAASWLDSVVADVALEAEAAGVTCEISACQ 312
Cdd:COG5002 191 LDGAadDPEERREYLEIILEEAERLSRLVNDLLDLSRLESGELKLEKEPVDLAELLEEVVEELRPLAEEKGIELELDLPE 270
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489178403 313 VE-QIRIEPRFMARAVINLLRNAIRH--AHSRVEIALLDQGDSCQIRVNDDGPGIPADARQKIFEPFSRLDDSRDRSTGG 389
Cdd:COG5002 271 DPlLVLGDPDRLEQVLTNLLDNAIKYtpEGGTITVSLREEDDQVRISVRDTGIGIPEEDLPRIFERFYRVDKSRSRETGG 350
|
330 340 350
....*....|....*....|....*....|....
gi 489178403 390 FGLGLAIVRRVAQWHGGYAEALETPQGGASFRLT 423
Cdd:COG5002 351 TGLGLAIVKHIVEAHGGRIWVESEPGKGTTFTIT 384
|
|
| BaeS |
COG0642 |
Signal transduction histidine kinase [Signal transduction mechanisms]; |
92-424 |
7.91e-55 |
|
Signal transduction histidine kinase [Signal transduction mechanisms];
Pssm-ID: 440407 [Multi-domain] Cd Length: 328 Bit Score: 184.73 E-value: 7.91e-55
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489178403 92 QALLDKNLLVVREDFTEFISRIDAGPQLLDIKLPPEPSLTPLFTVLAYILLGVLVGIALLVWVRPHWRDLETLRLAAQRF 171
Cdd:COG0642 4 LLLLLVLLLLLLLLLLLALLLLLLLLLLLALLLLLALLLLLLLLLLLLLLLALALLALLLLLLLLLLLLLLLLLLLLLLL 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489178403 172 GDGDLSSRTRIFRRSDIRTLAQHFNQmadrieslisnQRELTNAVSHELRTPISRLSFELEQLNKQVDAEVRHDLiEDMR 251
Cdd:COG0642 84 LLLLLLLLLLLLLLALLLLLEEANEA-----------KSRFLANVSHELRTPLTAIRGYLELLLEELDEEQREYL-ETIL 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489178403 252 ADLGELEEMVSELLTYARLEHGNVGSHREIVDAASWLDSVVADVALEAEAAGVTCEISAC-QVEQIRIEPRFMARAVINL 330
Cdd:COG0642 152 RSADRLLRLINDLLDLSRLEAGKLELEPEPVDLAELLEEVVELFRPLAEEKGIELELDLPdDLPTVRGDPDRLRQVLLNL 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489178403 331 LRNAIRHAH--SRVEIALLDQGDSCQIRVNDDGPGIPADARQKIFEPFSRLDDSrdRSTGGFGLGLAIVRRVAQWHGGYA 408
Cdd:COG0642 232 LSNAIKYTPegGTVTVSVRREGDRVRISVEDTGPGIPPEDLERIFEPFFRTDPS--RRGGGTGLGLAIVKRIVELHGGTI 309
|
330
....*....|....*.
gi 489178403 409 EALETPQGGASFRLTW 424
Cdd:COG0642 310 EVESEPGKGTTFTVTL 325
|
|
| KdpD |
COG2205 |
K+-sensing histidine kinase KdpD [Signal transduction mechanisms]; |
194-423 |
9.45e-55 |
|
K+-sensing histidine kinase KdpD [Signal transduction mechanisms];
Pssm-ID: 441807 [Multi-domain] Cd Length: 239 Bit Score: 181.64 E-value: 9.45e-55
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489178403 194 HFNQMADRIESLISNQRELTNAVSHELRTPISRLSFELEQLNKQVD--AEVRHDLIEDMRADLGELEEMVSELLTYARLE 271
Cdd:COG2205 1 ELEEALEELEELERLKSEFLANVSHELRTPLTSILGAAELLLDEEDlsPEERRELLEIIRESAERLLRLIEDLLDLSRLE 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489178403 272 HGNVGSHREIVDAASWLDSVVADVALEAEAAGVTCEIS-ACQVEQIRIEPRFMARAVINLLRNAIRH--AHSRVEIALLD 348
Cdd:COG2205 81 SGKLSLELEPVDLAELLEEAVEELRPLAEEKGIRLELDlPPELPLVYADPELLEQVLANLLDNAIKYspPGGTITISARR 160
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 489178403 349 QGDSCQIRVNDDGPGIPADARQKIFEPFSRLDdsRDRSTGGFGLGLAIVRRVAQWHGGYAEALETPQGGASFRLT 423
Cdd:COG2205 161 EGDGVRISVSDNGPGIPEEELERIFERFYRGD--NSRGEGGTGLGLAIVKRIVEAHGGTIWVESEPGGGTTFTVT 233
|
|
| cpxA |
PRK09470 |
envelope stress sensor histidine kinase CpxA; |
108-427 |
9.80e-47 |
|
envelope stress sensor histidine kinase CpxA;
Pssm-ID: 236532 [Multi-domain] Cd Length: 461 Bit Score: 167.03 E-value: 9.80e-47
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489178403 108 EFISRIDAGPQLLdiklppepsltplftvlayILLGVLVGIALLVWV-----RPHWRdletLRLAAQRFGDG------DL 176
Cdd:PRK09470 159 DFINLLFDRPLLL-------------------LLVTMLVSTPLLLWLawslaKPARK----LKNAADEVAQGnlrqhpEL 215
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489178403 177 SSRTRIFRRsdirtLAQHFNQMADRIESLISNQRELTNAVSHELRTPISRL-------------SFELEQLnkqvdaevr 243
Cdd:PRK09470 216 ETGPQEFRQ-----AGASFNQMVTALERMMTSQQRLLSDISHELRTPLTRLqlatallrrrqgeSKELERI--------- 281
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489178403 244 hdlieDMRADlgELEEMVSELLTYARLEHgNVGSHREIVDAASWLDSVVADVALEAEAAGVTCEISAcQVEQIRI--EPR 321
Cdd:PRK09470 282 -----ETEAQ--RLDSMINDLLVLSRNQQ-KNHLERETFKANSLWSEVLEDAKFEAEQMGKSLTVSA-PPGPWPIngNPN 352
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489178403 322 FMARAVINLLRNAIRHAHSRVEIALLDQGDSCQIRVNDDGPGIPADARQKIFEPFSRLDDSRDRSTGGFGLGLAIVRRVA 401
Cdd:PRK09470 353 ALASALENIVRNALRYSHTKIEVAFSVDKDGLTITVDDDGPGVPEEEREQIFRPFYRVDEARDRESGGTGLGLAIVENAI 432
|
330 340
....*....|....*....|....*.
gi 489178403 402 QWHGGYAEALETPQGGasFRLTWERP 427
Cdd:PRK09470 433 QQHRGWVKAEDSPLGG--LRLTIWLP 456
|
|
| MtrAB_MtrB |
NF040691 |
MtrAB system histidine kinase MtrB; |
135-423 |
3.97e-42 |
|
MtrAB system histidine kinase MtrB;
Pssm-ID: 468655 [Multi-domain] Cd Length: 507 Bit Score: 155.18 E-value: 3.97e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489178403 135 TVLAYILLGVLVGIALLVWVRPHwRDLETLRLA---AQRFGDGDLSSRTRIFRRSDIRTLAQHFNQMADRIESLISN--- 208
Cdd:NF040691 188 GTLLLGGLALVVLLGLIAWLVTR-QVVAPVRSAartAERFAAGDLSERMPVKGEDDLARLARSFNQMADSLQRQIRQlee 266
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489178403 209 ----QRELTNAVSHELRTPISRLsfeleQLNKQVDAEVRHDL-------IEDMRADLGELEEMVSELLTYARLEHGNVGS 277
Cdd:NF040691 267 lsrlQQRFVSDVSHELRTPLTTI-----RMAADVIHDSRDDFdpatarsAELLHTELDRFESLLSDLLEISRFDAGAAEL 341
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489178403 278 HREIVDAASWLDSVVADVALEAEAAGVTCEISACQVEQI-RIEPRFMARAVINLLRNAIRHA-HSRVEIALLDQGDSCQI 355
Cdd:NF040691 342 DVEPVDLRPLVRRVVDALRQLAERAGVELRVDAPGTPVVaEVDPRRVERVLRNLVVNAIEHGeGKPVVVTVAQDDTAVAV 421
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 489178403 356 RVNDDGPGIPADARQKIFEPFSRLDDSRDRSTGGFGLGLAIVRRVAQWHGGYAEALETPQGGASFRLT 423
Cdd:NF040691 422 TVRDHGVGLKPGEVALVFDRFWRADPARARTTGGTGLGLAIALEDARLHGGWLEAWGRPGQGSQFRLT 489
|
|
| cztS_silS_copS |
TIGR01386 |
heavy metal sensor kinase; Members of this family contain a sensor histidine kinase domain ... |
135-423 |
2.71e-40 |
|
heavy metal sensor kinase; Members of this family contain a sensor histidine kinase domain (pfam00512) and a domain found in bacterial signal proteins (pfam00672). This group is separated phylogenetically from related proteins with similar architecture and contains a number of proteins associated with heavy metal resistance efflux systems for copper, silver, cadmium, and/or zinc.
Pssm-ID: 273593 [Multi-domain] Cd Length: 457 Bit Score: 149.46 E-value: 2.71e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489178403 135 TVLAYILLGVLvGIALLVW--VRPHWRDLETLRLAAQRFGDGDLSSRTRIFRRS-DIRTLAQHFNQMADRIESLISNQRE 211
Cdd:TIGR01386 165 WLILIAVLLVL-LTALLGWwiTRLGLEPLRRLSAVAARISPESLDQRLDPSRAPaELRELAQSFNAMLGRLEDAFQRLSQ 243
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489178403 212 LTNAVSHELRTPISRLSFELE-QLNKQVDAEVRHDLIEDMRADLGELEEMVSELLTYARLEHGNVGSHREIVDAASWLDS 290
Cdd:TIGR01386 244 FSADLAHELRTPLTNLLGQTQvALSQPRTGEEYREVLESNLEELERLSRMVSDMLFLARADNGQLALERVRLDLAAELAK 323
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489178403 291 VVADVALEAEAAGVTCEISA-CQVeqiRIEPRFMARAVINLLRNAIRHA--HSRVEIALLDQGDSCQIRVNDDGPGIPAD 367
Cdd:TIGR01386 324 VAEYFEPLAEERGVRIRVEGeGLV---RGDPQMFRRAISNLLSNALRHTpdGGTITVRIERRSDEVRVSVSNPGPGIPPE 400
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*.
gi 489178403 368 ARQKIFEPFSRLDDSRDRSTGGFGLGLAIVRRVAQWHGGYAEAlETPQGGASFRLT 423
Cdd:TIGR01386 401 HLSRLFDRFYRVDPARSNSGEGTGLGLAIVRSIMEAHGGRASA-ESPDGKTRFILR 455
|
|
| envZ |
PRK09467 |
osmolarity sensor protein; Provisional |
127-417 |
1.55e-35 |
|
osmolarity sensor protein; Provisional
Pssm-ID: 236531 [Multi-domain] Cd Length: 435 Bit Score: 135.81 E-value: 1.55e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489178403 127 EPSLTPLFTVLAYILLGVLVGIALlvWVRPHWRDLETLRLAAQRFGDGDLSSRTRIFRRSDIRTLAQHFNQMADRIESLI 206
Cdd:PRK09467 149 QGDFSPLFRYTLAIGLLSVAGGWL--FIRIQNRPLVALEHAALQVGKGEIPPPLREYGASEVRSVTRAFNQMAAGIKQLE 226
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489178403 207 SNQRELTNAVSHELRTPISRLSFELEQLNKQVDAevrhdLIEDMRADLGELEEMVSELLTYARleHGNVGShREIVDaas 286
Cdd:PRK09467 227 DDRTLLMAGVSHDLRTPLTRIRLATEMMSEEDGY-----LAESINKDIEECNAIIEQFIDYLR--TGQEMP-MEMAD--- 295
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489178403 287 wLDSVVADVAL-------EAEAAGVTCEIsacqveQIRIEPRFMARAVINLLRNAIRHAHSRVEIALLDQGDSCQIRVND 359
Cdd:PRK09467 296 -LNALLGEVIAaesgyerEIETALQPGPI------EVPMNPIAIKRALANLVVNAARYGNGWIKVSSGTEGKRAWFQVED 368
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*...
gi 489178403 360 DGPGIPADARQKIFEPFSRLDDSrdRSTGGFGLGLAIVRRVAQWHGGYAEALETPQGG 417
Cdd:PRK09467 369 DGPGIPPEQLKHLFQPFTRGDSA--RGSSGTGLGLAIVKRIVDQHNGKVELGNSEEGG 424
|
|
| COG4251 |
COG4251 |
Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal ... |
20-424 |
7.28e-35 |
|
Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms];
Pssm-ID: 443393 [Multi-domain] Cd Length: 503 Bit Score: 135.30 E-value: 7.28e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489178403 20 IFVVDHVIDAFYDSIVENYHRDAVRGQAYSLVEKLAPLDQAGRQRQLEDWRPHYGLELSLTDARQAKLTQEEQALLDKNL 99
Cdd:COG4251 83 LLLLLELALVLLALLLVLLLLLALLLLLALLLLLELLLLLLALLLLLLLLALLLLEELALLRLALALLLLLLLLLLLLLL 162
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489178403 100 LVVREDFTEFISRIDAGPQLLDIKLPPEPSLTPLFTVLAYILLGVLVGIALLVWVRPHWRDLETLRLAAQRFGDGDLSSR 179
Cdd:COG4251 163 LLALILALLLAALAELELLLLLLLVLLLLLLLLLLLLLLLLRLLLELLLLLEAELLLSLGGGLGLLLLLLLLLVLLLLLI 242
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489178403 180 TRIFRRSDIRTLAQHFNQMADRIESLISNQRELTNA----------VSHELRTPISR----LSFELEQLNKQVDAEVRhD 245
Cdd:COG4251 243 LLLLLLILVLELLELRLELEELEEELEERTAELERSneeleqfayvASHDLREPLRKisgfSQLLEEDYGDKLDEEGR-E 321
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489178403 246 LIEDMRADLGELEEMVSELLTYARLehGNVGSHREIVDAASWLDSVVADVALEAEAAGVTCEISacQVEQIRIEPRFMAR 325
Cdd:COG4251 322 YLERIRDAAERMQALIDDLLAYSRV--GRQELEFEPVDLNELLEEVLEDLEPRIEERGAEIEVG--PLPTVRGDPTLLRQ 397
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489178403 326 AVINLLRNAIRHAHS----RVEIALLDQGDSCQIRVNDDGPGIPADARQKIFEPFSRLDDSRDRStgGFGLGLAIVRRVA 401
Cdd:COG4251 398 VFQNLISNAIKYSRPgeppRIEIGAEREGGEWVFSVRDNGIGIDPEYAEKIFEIFQRLHSRDEYE--GTGIGLAIVKKIV 475
|
410 420
....*....|....*....|...
gi 489178403 402 QWHGGYAEALETPQGGASFRLTW 424
Cdd:COG4251 476 ERHGGRIWVESEPGEGATFYFTL 498
|
|
| NtrY |
COG5000 |
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism ... |
133-423 |
1.09e-33 |
|
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms];
Pssm-ID: 444024 [Multi-domain] Cd Length: 422 Bit Score: 130.47 E-value: 1.09e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489178403 133 LFTVLAYILLGVLVGIALLVW-----VRPhwrdLETLRLAAQRFGDGDLSSRTRIFRRSDIRTLAQHFNQMADRIES--- 204
Cdd:COG5000 8 LLLLLLIALLLLLLALWLALLlarrlTRP----LRRLAEATRAVAAGDLSVRLPVTGDDEIGELARAFNRMTDQLKEqre 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489178403 --------------------------------------------------------------------------------
Cdd:COG5000 84 eleerrryletilenlpagvivldadgritlanpaaerllgipleeligkpleellpeldlaellrealergwqeeielt 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489178403 205 ----------------------------LISNQR-----ELTNAVSHELRTPIS--RLSFEL--EQLNKQV--DAEVRHD 245
Cdd:COG5000 164 rdgrrtllvrasplrddgyvivfdditeLLRAERlaawgELARRIAHEIKNPLTpiQLSAERlrRKLADKLeeDREDLER 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489178403 246 LIEDMRADLGELEEMVSELLTYARLEHgnvgSHREIVDAASWLDSVVADVALEAEAAGVTCEIS-ACQVEQIRIEPRFMA 324
Cdd:COG5000 244 ALDTIIRQVDRLKRIVDEFLDFARLPE----PQLEPVDLNELLREVLALYEPALKEKDIRLELDlDPDLPEVLADRDQLE 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489178403 325 RAVINLLRNAIR--HAHSRVEIALLDQGDSCQIRVNDDGPGIPADARQKIFEPFSrlddsrdrST--GGFGLGLAIVRRV 400
Cdd:COG5000 320 QVLINLLKNAIEaiEEGGEIEVSTRREDGRVRIEVSDNGPGIPEEVLERIFEPFF--------TTkpKGTGLGLAIVKKI 391
|
410 420
....*....|....*....|...
gi 489178403 401 AQWHGGYAEALETPQGGASFRLT 423
Cdd:COG5000 392 VEEHGGTIELESRPGGGTTFTIR 414
|
|
| PRK11100 |
PRK11100 |
sensory histidine kinase CreC; Provisional |
137-428 |
1.40e-33 |
|
sensory histidine kinase CreC; Provisional
Pssm-ID: 236846 [Multi-domain] Cd Length: 475 Bit Score: 131.12 E-value: 1.40e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489178403 137 LAYILLGVLVGIALLVWVRphwRDLETLRLAAQRFGDGDlSSRTRIFRRSDIRTLAQHFNQMADR------IESLIsnqR 210
Cdd:PRK11100 189 ALLLGIALLIGAGVVWWLN---RSIRRLTRYADAVTEGK-PVPLPKLGSSELRELAQALESMRVKlegkayVEQYV---Q 261
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489178403 211 ELTnavsHELRTPISRLSFELEQLNKQVDAEVRHDLIEDMRADLGELEEMVSELLTYARLEHGNVGSHREIVDAASWLDS 290
Cdd:PRK11100 262 TLT----HELKSPLAAIRGAAELLQEDPPPEDRARFTGNILTQSARLQQLIDRLLELARLEQRQELEVLEPVALAALLEE 337
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489178403 291 VVADVALEAEAAGVTCEISACQVeQIRIEPRFMARAVINLLRNAI--RHAHSRVEIALLDQGDSCQIRVNDDGPGIPADA 368
Cdd:PRK11100 338 LVEAREAQAAAKGITLRLRPDDA-RVLGDPFLLRQALGNLLDNAIdfSPEGGTITLSAEVDGEQVALSVEDQGPGIPDYA 416
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 489178403 369 RQKIFEPFSRL--DDSRDRSTGgfgLGLAIVRRVAQWHGGYAEALETPQGGASFRLTWERPR 428
Cdd:PRK11100 417 LPRIFERFYSLprPANGRKSTG---LGLAFVREVARLHGGEVTLRNRPEGGVLATLTLPRHF 475
|
|
| BaeS_SmeS |
NF012163 |
sensor histidine kinase efflux regulator BaeS; |
137-423 |
9.85e-33 |
|
sensor histidine kinase efflux regulator BaeS;
Pssm-ID: 411086 [Multi-domain] Cd Length: 457 Bit Score: 128.41 E-value: 9.85e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489178403 137 LAYILLGVLVGIALLVWVRPHWRDLETLRLAAQRFGDGDLSSRTRIFRRSDIRTLAQHFNQMADRIESLISNQRELTNAV 216
Cdd:NF012163 168 LIVALALLLAALAAFLLARGLLAPVKRLVEATHRLAAGDYTTRVTPTSNDELGKLAQDFNQLASTLEKNEQMRRDFMADI 247
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489178403 217 SHELRTPISRLSFELEQLNKQVDAEVRHDLIEdMRADLGELEEMVSELLTYARLEHGNVGSHREIVDAASWLDSVVADVA 296
Cdd:NF012163 248 SHELRTPLAVLRAELEAIQDGIRKFTPESLDS-LQAEVGTLTKLVDDLHDLSMSDEGALAYQKASVDLVPLLEVEGGAFR 326
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489178403 297 LEAEAAGVTCEISACQVEQIRIEPRFMARAVINLLRNAIRHAHS--RVEIALLDQGDSCQIRVNDDGPGIPADARQKIFE 374
Cdd:NF012163 327 ERFASAGLELEVSLPDSSLVFGDRDRLMQLFNNLLENSLRYTDSggSLHISASQRPKEVTLTVADSAPGVSDEQLARLFE 406
|
250 260 270 280
....*....|....*....|....*....|....*....|....*....
gi 489178403 375 PFSRLDDSRDRSTGGFGLGLAIVRRVAQWHGGYAEALETPQGGASFRLT 423
Cdd:NF012163 407 RFYRVEVSRNRASGGSGLGLAISLNIVQAHGGTLHAAHSPLGGLRIVVT 455
|
|
| HATPase_CpxA-like |
cd16949 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
323-423 |
4.37e-32 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CpxA; This family includes the histidine kinase-like ATPase (HATPase) domains of two-component sensor histidine kinase (HKs) similar to Escherichia coli CpxA, HK of the CpxA-CpxR two-component regulatory system (TCS) which may function in acid stress and in cell wall stability. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a CpxA family periplasmic domain.
Pssm-ID: 340425 [Multi-domain] Cd Length: 104 Bit Score: 117.43 E-value: 4.37e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489178403 323 MARAVINLLRNAIRHAHSRVEIALLDQGDSCQIRVNDDGPGIPADARQKIFEPFSRLDDSRDRSTGGFGLGLAIVRRVAQ 402
Cdd:cd16949 1 LARALENVLRNALRYSPSKILLDISQDGDQWTITITDDGPGVPEDQLEQIFLPFYRVDSARDRESGGTGLGLAIAERAIE 80
|
90 100
....*....|....*....|.
gi 489178403 403 WHGGYAEALETPQGGASFRLT 423
Cdd:cd16949 81 QHGGKIKASNRKPGGLRVRIW 101
|
|
| HATPase_c |
smart00387 |
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases. |
320-424 |
2.51e-31 |
|
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
Pssm-ID: 214643 [Multi-domain] Cd Length: 111 Bit Score: 115.82 E-value: 2.51e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489178403 320 PRFMARAVINLLRNAIRHAHS--RVEIALLDQGDSCQIRVNDDGPGIPADARQKIFEPFSRLDDsRDRSTGGFGLGLAIV 397
Cdd:smart00387 3 PDRLRQVLSNLLDNAIKYTPEggRITVTLERDGDHVEITVEDNGPGIPPEDLEKIFEPFFRTDK-RSRKIGGTGLGLSIV 81
|
90 100
....*....|....*....|....*..
gi 489178403 398 RRVAQWHGGYAEALETPQGGASFRLTW 424
Cdd:smart00387 82 KKLVELHGGEISVESEPGGGTTFTITL 108
|
|
| COG4191 |
COG4191 |
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal ... |
98-423 |
4.03e-31 |
|
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms];
Pssm-ID: 443345 [Multi-domain] Cd Length: 361 Bit Score: 122.21 E-value: 4.03e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489178403 98 NLLVVREDFTEFISRIDAGPQLLDIKLPPEPSLTPLFTVLAYILLGVLVGIALLVWVRPHWRDLETLRLAAQRFGDGDLS 177
Cdd:COG4191 19 ALALALLLLLLLLLLALLLLLLALLLALLALLLLLLLLLLLLLLELLLLLLALLGGLLRLLLLLGLLLLLLLEALLLLLL 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489178403 178 SRTRIFRRSDIRTLAQHFNQMADRIESLISNQR------------ELTNAVSHELRTPI----SRLSFELEQLNKQVDAE 241
Cdd:COG4191 99 AALDAEENAELEELERDITELERAEEELRELQEqlvqseklaalgELAAGIAHEINNPLaailGNAELLRRRLEDEPDPE 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489178403 242 VRHDLIEDMRADLGELEEMVSELLTYARLEHgnvgSHREIVDAASWLDSVVADVALEAEAAGVTCEIS-ACQVEQIRIEP 320
Cdd:COG4191 179 ELREALERILEGAERAAEIVRSLRAFSRRDE----EEREPVDLNELIDEALELLRPRLKARGIEVELDlPPDLPPVLGDP 254
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489178403 321 RFMARAVINLLRNAIrHA-----HSRVEIALLDQGDSCQIRVNDDGPGIPADARQKIFEPFSrlddSRDRSTGGFGLGLA 395
Cdd:COG4191 255 GQLEQVLLNLLINAI-DAmeegeGGRITISTRREGDYVVISVRDNGPGIPPEVLERIFEPFF----TTKPVGKGTGLGLS 329
|
330 340
....*....|....*....|....*...
gi 489178403 396 IVRRVAQWHGGYAEALETPQGGASFRLT 423
Cdd:COG4191 330 ISYGIVEKHGGRIEVESEPGGGTTFTIT 357
|
|
| HATPase |
cd00075 |
Histidine kinase-like ATPase domain; This superfamily includes the histidine kinase-like ... |
323-424 |
7.77e-30 |
|
Histidine kinase-like ATPase domain; This superfamily includes the histidine kinase-like ATPase (HATPase) domains of several ATP-binding proteins such as histidine kinase, DNA gyrase B, topoisomerases, heat shock protein 90 (HSP90), phytochrome-like ATPases and DNA mismatch repair proteins. Domains belonging to this superfamily are also referred to as GHKL (gyrase, heat-shock protein 90, histidine kinase, MutL) ATPase domains.
Pssm-ID: 340391 [Multi-domain] Cd Length: 102 Bit Score: 111.54 E-value: 7.77e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489178403 323 MARAVINLLRNAIRHA--HSRVEIALLDQGDSCQIRVNDDGPGIPADARQKIFEPFSRLDDSRDRstGGFGLGLAIVRRV 400
Cdd:cd00075 1 LEQVLSNLLDNALKYSppGGTIEISLRQEGDGVVLEVEDNGPGIPEEDLERIFERFYRGDKSREG--GGTGLGLAIVRRI 78
|
90 100
....*....|....*....|....
gi 489178403 401 AQWHGGYAEALETPQGGASFRLTW 424
Cdd:cd00075 79 VEAHGGRITVESEPGGGTTFTVTL 102
|
|
| HATPase_c |
pfam02518 |
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the ... |
320-428 |
1.27e-27 |
|
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.
Pssm-ID: 460579 [Multi-domain] Cd Length: 109 Bit Score: 105.53 E-value: 1.27e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489178403 320 PRFMARAVINLLRNAIRHAHSRVEIAL-LDQGDSCQIRVNDDGPGIPADARQKIFEPFSRLDDsrdRSTGGFGLGLAIVR 398
Cdd:pfam02518 3 ELRLRQVLSNLLDNALKHAAKAGEITVtLSEGGELTLTVEDNGIGIPPEDLPRIFEPFSTADK---RGGGGTGLGLSIVR 79
|
90 100 110
....*....|....*....|....*....|
gi 489178403 399 RVAQWHGGYAEALETPQGGASFRLTWERPR 428
Cdd:pfam02518 80 KLVELLGGTITVESEPGGGTTVTLTLPLAQ 109
|
|
| PRK10337 |
PRK10337 |
sensor protein QseC; Provisional |
129-424 |
1.33e-26 |
|
sensor protein QseC; Provisional
Pssm-ID: 182388 [Multi-domain] Cd Length: 449 Bit Score: 110.89 E-value: 1.33e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489178403 129 SLTPLFTVLAYILLgvlvgiaLLVWVRphWRDLETL-RLAAQ-RFGDGDLS---SRTRIfrRSDIRTLAQHFNQMADRIE 203
Cdd:PRK10337 163 QLIPWLVALPIMLI-------ILMVLL--GRELAPLkKLALAlRMRDPDSEtplNATGV--PSEVRPLVEALNQLFARTH 231
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489178403 204 SLISNQRELTNAVSHELRTPISRLSFELE--QLNkQVDAEVRHDLIEDMRADLGELEEMVSELLTYARLEHGNVGSHREI 281
Cdd:PRK10337 232 AMMVRERRFTSDAAHELRSPLAALKVQTEvaQLS-DDDPQARKKALLQLHAGIDRATRLVDQLLTLSRLDSLDNLQDVAE 310
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489178403 282 VDAASWLDSVVADVALEAEAAGVTCEISACQVEQIR-IEPRFMARAVINLLRNAIRHAH--SRVEIALLDQGdscqIRVN 358
Cdd:PRK10337 311 IPLEDLLQSAVMDIYHTAQQAGIDVRLTLNAHPVIRtGQPLLLSLLVRNLLDNAIRYSPqgSVVDVTLNARN----FTVR 386
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 489178403 359 DDGPGIPADARQKIFEPFSRlddSRDRSTGGFGLGLAIVRRVAQWHGGYAEALETPQGGASFRLTW 424
Cdd:PRK10337 387 DNGPGVTPEALARIGERFYR---PPGQEATGSGLGLSIVRRIAKLHGMNVSFGNAPEGGFEAKVSW 449
|
|
| PRK10549 |
PRK10549 |
two-component system sensor histidine kinase BaeS; |
163-427 |
2.40e-25 |
|
two-component system sensor histidine kinase BaeS;
Pssm-ID: 182539 [Multi-domain] Cd Length: 466 Bit Score: 107.41 E-value: 2.40e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489178403 163 TLRLAAqrfgdGDLSSRTRIFRRSDIRTLAQHFNQMADRIESLISNQRELTNAVSHELRTPISRLSFELEQLN---KQVD 239
Cdd:PRK10549 199 THKLAA-----GDFTTRVTPTSRDELGRLAQDFNQLASTLEKNEQMRRDFMADISHELRTPLAVLRGELEAIQdgvRKFT 273
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489178403 240 AEVRHDLiedmRADLGELEEMVSELLTYARLEHGNVGSHREIVDAASWLDSVVADVALEAEAAGVTCEISAcqVEQIRI- 318
Cdd:PRK10549 274 PESVASL----QAEVGTLTKLVDDLHQLSLSDEGALAYRKTPVDLVPLLEVAGGAFRERFASRGLTLQLSL--PDSATVf 347
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489178403 319 -EPRFMARAVINLLRNAIRH--AHSRVEIALLDQGDSCQIRVNDDGPGIPADARQKIFEPFSRLDDSRDRSTGGFGLGLA 395
Cdd:PRK10549 348 gDPDRLMQLFNNLLENSLRYtdSGGSLHISAEQRDKTLRLTFADSAPGVSDEQLQKLFERFYRTEGSRNRASGGSGLGLA 427
|
250 260 270
....*....|....*....|....*....|..
gi 489178403 396 IVRRVAQWHGGYAEALETPQGGasFRLTWERP 427
Cdd:PRK10549 428 ICLNIVEAHNGRIIAAHSPFGG--VSITVELP 457
|
|
| AdeS_HK |
NF012226 |
two-component sensor histidine kinase AdeS; Mutations in this component of the two-component ... |
167-422 |
5.49e-25 |
|
two-component sensor histidine kinase AdeS; Mutations in this component of the two-component regulatory system for the AdeABC efflux pump can confer adaptive resistance to certain antibiotics, including tigecycline.
Pssm-ID: 411090 [Multi-domain] Cd Length: 353 Bit Score: 105.08 E-value: 5.49e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489178403 167 AAQRFGDGDLSSRT--RIFRRSDIRTLAQHFNQMADRIESLISNQRELTNAVSHELRTPISRLSFELEQLnkqVDAEVRH 244
Cdd:NF012226 94 AAKKISQGDLSARAedSQIHSAEISELMHNFNDMAQKLESSVKNAQVWNAAIAHELRTPITILQGRLQGI---LDGVFEP 170
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489178403 245 D--LIEDMRADLGELEEMVSELLTYARLEHGNVGSHREIVDAASWLDSVVADVALEAEAAGVT--CEISA--CQVEQIRI 318
Cdd:NF012226 171 DpaLFKSLLNQVEGLSHLVEDLRTLSLVENQQLRLNYESVDLKDSIEKVLKMFEDRLEQAQLTivLNLTAtpVFCDRRRI 250
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489178403 319 EPRFMAravinLLRNAIRHAHS-RVEIALLDQGDSCQIRVNDDGPGIPADARQKIFEPFSRLDDSRDRSTGGFGLGLAIV 397
Cdd:NF012226 251 EQVLIA-----LIDNAIRYANAgKLKISSSVIQDDWILQIEDEGPGIAEEYQQDLFNPFFRLEQSRNKEFGGTGLGLAVV 325
|
250 260
....*....|....*....|....*
gi 489178403 398 RRVAQWHGGYAEaLETPQGGASFRL 422
Cdd:NF012226 326 HAIVIAHKGSIE-YSNSQGNSVFTI 349
|
|
| phoR_proteo |
TIGR02966 |
phosphate regulon sensor kinase PhoR; Members of this protein family are the regulatory ... |
216-421 |
8.69e-25 |
|
phosphate regulon sensor kinase PhoR; Members of this protein family are the regulatory histidine kinase PhoR associated with the phosphate ABC transporter in most Proteobacteria. Related proteins from Gram-positive organisms are not included in this model. The phoR gene usually is adjacent to the response regulator phoB gene (TIGR02154). [Signal transduction, Two-component systems]
Pssm-ID: 274368 [Multi-domain] Cd Length: 333 Bit Score: 104.21 E-value: 8.69e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489178403 216 VSHELRTPISRLSFELEQL--NKQVDAEVRHDLIEDMRADLGELEEMVSELLTYARLEHGNVGSHREIVDAASWLDSVVA 293
Cdd:TIGR02966 121 VSHELRTPLTVLRGYLETLadGPDEDPEEWNRALEIMLEQSQRMQSLVEDLLTLSRLESAASPLEDEPVDMPALLDHLRD 200
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489178403 294 DVALEAEAAGVTCEISACQVEQIRIEPRFMARAVINLLRNAIRH--AHSRVEIALLDQGDSCQIRVNDDGPGIPADARQK 371
Cdd:TIGR02966 201 EAEALSQGKNHQITFEIDGGVDVLGDEDELRSAFSNLVSNAIKYtpEGGTITVRWRRDGGGAEFSVTDTGIGIAPEHLPR 280
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|
gi 489178403 372 IFEPFSRLDDSRDRSTGGFGLGLAIVRRVAQWHGGYAEALETPQGGASFR 421
Cdd:TIGR02966 281 LTERFYRVDKSRSRDTGGTGLGLAIVKHVLSRHHARLEIESELGKGSTFS 330
|
|
| PRK10755 |
PRK10755 |
two-component system sensor histidine kinase PmrB; |
196-406 |
1.13e-23 |
|
two-component system sensor histidine kinase PmrB;
Pssm-ID: 236751 [Multi-domain] Cd Length: 356 Bit Score: 101.20 E-value: 1.13e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489178403 196 NQMADRIESLISNQRELTNAVSHELRTPIS--RLSFELEQLNKQVDAEVrhdLIEdmRADlgELEEMVSELLTYARLEHG 273
Cdd:PRK10755 124 NQLVSRLTSTLDQERLFTADVAHELRTPLAgiRLHLELLEKQHHIDVAP---LIA--RLD--QMMHTVEQLLQLARAGQS 196
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489178403 274 NVGSHREIVDaasWLDSVV----ADVALEAEAAGVTCEI----SACQVEQIRIEPRFMARaviNLLRNAIRHA--HSRVE 343
Cdd:PRK10755 197 FSSGHYQTVK---LLEDVIlpsqDELSEMLEQRQQTLLLpesaADITVQGDATLLRLLLR---NLVENAHRYSpeGSTIT 270
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 489178403 344 IALLDQGDSCQIRVNDDGPGIPADARQKIFEPFSRLddsrDRSTGGFGLGLAIVRRVAQWHGG 406
Cdd:PRK10755 271 IKLSQEDGGAVLAVEDEGPGIDESKCGELSKAFVRM----DSRYGGIGLGLSIVSRITQLHHG 329
|
|
| PRK10490 |
PRK10490 |
sensor protein KdpD; Provisional |
212-423 |
2.99e-22 |
|
sensor protein KdpD; Provisional
Pssm-ID: 236701 [Multi-domain] Cd Length: 895 Bit Score: 99.73 E-value: 2.99e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489178403 212 LTNAVSHELRTPISRLSFELEQLNKQVDAE-VRHDL-IEDMRADLGELEEMVSELLTYARLEHGNVGSHREivdaasW-- 287
Cdd:PRK10490 667 LLAALSHDLRTPLTVLFGQAEILTLDLASEgSPHARqASEIRQQVLNTTRLVNNLLDMARIQSGGFNLRKE------Wlt 740
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489178403 288 LDSVV--ADVALEAEAAGVTCEISACQ-VEQIRIEPRFMARAVINLLRNAIRHAHSRVEIAL--LDQGDSCQIRVNDDGP 362
Cdd:PRK10490 741 LEEVVgsALQMLEPGLSGHPINLSLPEpLTLIHVDGPLFERVLINLLENAVKYAGAQAEIGIdaHVEGERLQLDVWDNGP 820
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 489178403 363 GIPADARQKIFEPFSRLDdsRDRSTGGFGLGLAIVRRVAQWHGGYAEALETPQGGASFRLT 423
Cdd:PRK10490 821 GIPPGQEQLIFDKFARGN--KESAIPGVGLGLAICRAIVEVHGGTIWAENRPEGGACFRVT 879
|
|
| phoR |
PRK11006 |
phosphate regulon sensor histidine kinase PhoR; |
216-423 |
1.53e-21 |
|
phosphate regulon sensor histidine kinase PhoR;
Pssm-ID: 182895 [Multi-domain] Cd Length: 430 Bit Score: 96.23 E-value: 1.53e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489178403 216 VSHELRTPISRLSFELEQLNKQV-DAEVRHDLIEDMRADLGELEEMVSELLTYARLEHGNVGSHREIVDAASWLDSVVAD 294
Cdd:PRK11006 211 VSHELRTPLTVLQGYLEMMQDQPlEGALREKALHTMREQTQRMEGLVKQLLTLSKIEAAPTIDLNEKVDVPMMLRVLERE 290
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489178403 295 -VALEAEAAGVTCEI-SACQV----EQIRieprfmaRAVINLLRNAIRH----AHSRVEIALLDQGdsCQIRVNDDGPGI 364
Cdd:PRK11006 291 aQTLSQGKHTITFEVdNSLKVfgneDQLR-------SAISNLVYNAVNHtpegTHITVRWQRVPQG--AEFSVEDNGPGI 361
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*....
gi 489178403 365 PADARQKIFEPFSRLDDSRDRSTGGFGLGLAIVRRVAQWHGGYAEALETPQGGASFRLT 423
Cdd:PRK11006 362 APEHIPRLTERFYRVDKARSRQTGGSGLGLAIVKHALSHHDSRLEIESEVGKGTRFSFV 420
|
|
| HATPase_TutC-TodS-like |
cd16925 |
Histidine kinase-like ATPase domain of hybrid sensor histidine kinases similar to Pseudomonas ... |
319-422 |
2.38e-21 |
|
Histidine kinase-like ATPase domain of hybrid sensor histidine kinases similar to Pseudomonas putida TodS and Thauera aromatica TutC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinase (HKs) such Pseudomonas putida TodS HK of the TodS-TodT two-component regulatory system (TCS) which controls the expression of a toluene degradation pathway. Thauera aromatica TutC may be part of a TCS that is involved in anaerobic toluene metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), PAS sensor domain(s) and a REC domain.
Pssm-ID: 340402 [Multi-domain] Cd Length: 110 Bit Score: 88.70 E-value: 2.38e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489178403 319 EPRFMARAVINLLRNAIRHAHS--RVEIAL-LDQGDSCQIRVNDDGPGIPADARQKIFEPFSRLDDSRDRSTGGFGLGLA 395
Cdd:cd16925 1 DAEKYERVVLNLLSNAFKFTPDggRIRCILeKFRLNRFLLTVSDSGPGIPPNLREEIFERFRQGDGSSTRAHGGTGLGLS 80
|
90 100
....*....|....*....|....*..
gi 489178403 396 IVRRVAQWHGGYAEALETPQGGASFRL 422
Cdd:cd16925 81 IVKEFVELHGGTVTVSDAPGGGALFQV 107
|
|
| marine_sort_HK |
TIGR03785 |
proteobacterial dedicated sortase system histidine kinase; This histidine kinase protein is ... |
129-423 |
4.67e-21 |
|
proteobacterial dedicated sortase system histidine kinase; This histidine kinase protein is paired with an adjacent response regulator (TIGR03787) gene. It co-occurs with a variant sortase enzyme (TIGR03784), usually in the same gene neighborhood, in proteobacterial species most of which are marine, and with an LPXTG motif-containing sortase target conserved protein (TIGR03788). Sortases and LPXTG proteins are far more common in Gram-positive bacteria, where sortase systems mediate attachment to the cell wall or cross-linking of pilin structures. We give this predicted sensor histidine kinase the gene symbol psdS, for Proteobacterial Dedicated Sortase system Sensor histidine kinase.
Pssm-ID: 163497 [Multi-domain] Cd Length: 703 Bit Score: 95.58 E-value: 4.67e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489178403 129 SLTPLFTV-LAYILLGVLVGIALLVWVRphWRdLETLRLAAQRFGD--GDLSSRTRIFRRSD-IRTLAQHFNQMADRIES 204
Cdd:TIGR03785 404 ALEKLFNViLAIMSIGTLALFGFASWIS--WR-IRRLSDDAEAAIDsqGRISGAIPASRSRDeIGDLSRSFAQMVARLRQ 480
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489178403 205 LISNQRELTNAVSHELRTPISRLSFELEQLNKQVDAEVRHDLIEdmRADLGelEEMVSELLT----YARLEHGNVGSHRE 280
Cdd:TIGR03785 481 YTHYLENMSSRLSHELRTPVAVVRSSLENLELQALEQEKQKYLE--RAREG--TERLSMILNnmseATRLEQAIQSAEVE 556
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489178403 281 IVDAASWLDSVVAdvALEAEAAGVTCEISACQVEQI-RIEPRFMARAVINLLRNAIR--HAHSRVEIALLDQGDSCQIRV 357
Cdd:TIGR03785 557 DFDLSEVLSGCMQ--GYQMTYPPQRFELNIPETPLVmRGSPELIAQMLDKLVDNAREfsPEDGLIEVGLSQNKSHALLTV 634
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 489178403 358 NDDGPGIPADARQKIFEPFSRLDDSRDRSTGGFGLGLAIVRRVAQWHGGYAEALETPQG-GASFRLT 423
Cdd:TIGR03785 635 SNEGPPLPEDMGEQLFDSMVSVRDQGAQDQPHLGLGLYIVRLIADFHQGRIQAENRQQNdGVVFRIS 701
|
|
| HATPase_BaeS-like |
cd16946 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
319-423 |
9.03e-21 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BaeS HK of the BaeS/BaeR two-component regulatory system (TCS), which responds to envelope stress. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensory domain.
Pssm-ID: 340422 [Multi-domain] Cd Length: 109 Bit Score: 86.75 E-value: 9.03e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489178403 319 EPRFMARAVINLLRNAIRHAHS--RVEIALLDQGDSCQIRVNDDGPGIPADARQKIFEPFSRLDDSRDRSTGGFGLGLAI 396
Cdd:cd16946 1 DRDRLQQLFVNLLENSLRYTDTggKLRIRAAQTPQEVRLDVEDSAPGVSDDQLARLFERFYRVESSRNRASGGSGLGLAI 80
|
90 100
....*....|....*....|....*..
gi 489178403 397 VRRVAQWHGGYAEALETPQGGASFRLT 423
Cdd:cd16946 81 CHNIALAHGGTISAEHSPLGGLRLVLT 107
|
|
| PRK09835 |
PRK09835 |
Cu(+)/Ag(+) sensor histidine kinase; |
187-406 |
9.27e-21 |
|
Cu(+)/Ag(+) sensor histidine kinase;
Pssm-ID: 182101 [Multi-domain] Cd Length: 482 Bit Score: 94.07 E-value: 9.27e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489178403 187 DIRTLAQHFNQMADRIESLISNQRELTNAVSHELRTPISRL----SFELEQLNKQVDAEvrhDLIEDMRADLGELEEMVS 262
Cdd:PRK09835 240 ELEQLVLSFNHMIERIEDVFTRQSNFSADIAHEIRTPITNLitqtEIALSQSRSQKELE---DVLYSNLEELTRMAKMVS 316
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489178403 263 ELLTYARLEHGNVGSHREIVDAASWLDSVVADVALEAEAAGVTCEI--SACQVEQiriEPRFMARAVINLLRNAIRH--A 338
Cdd:PRK09835 317 DMLFLAQADNNQLIPEKKMLDLADEVGKVFDFFEAWAEERGVELRFvgDPCQVAG---DPLMLRRAISNLLSNALRYtpA 393
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 489178403 339 HSRVEIALLDQGDSCQIRVNDDGPGIPADARQKIFEPFSRLDDSRDRSTGGFGLGLAIVRRVAQWHGG 406
Cdd:PRK09835 394 GEAITVRCQEVDHQVQLVVENPGTPIAPEHLPRLFDRFYRVDPSRQRKGEGSGIGLAIVKSIVVAHKG 461
|
|
| HATPase_EvgS-ArcB-TorS-like |
cd16922 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid ... |
327-423 |
2.39e-20 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid sensor histidine kinases, similar to Escherichia coli EvgS, ArcB, TorS, BarA, RcsC; This family contains the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinases (HKs), including the following Escherichia coli HKs: EvgS, a HK of the EvgS-EvgA two-component system (TCS) that confers acid resistance; ArcB, a HK of the ArcB-ArcA TCS that modulates the expression of numerous genes in response to respiratory growth conditions; TorS, a HK of the TorS-TorR TCS which is involved in the anaerobic utilization of trimethylamine-N-oxide; BarA, a HK of the BarA-UvrY TCS involved in the regulation of carbon metabolism; and RcsC, a HK of the RcsB-RcsC TCS which regulates the expression of the capsule operon and of the cell division gene ftsZ. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), with most having accessory sensor domain(s) such as GAF, PAS and CHASE; many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340399 [Multi-domain] Cd Length: 110 Bit Score: 85.62 E-value: 2.39e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489178403 327 VINLLRNAIR-----HAHSRVEiALLDQGDSCQIR--VNDDGPGIPADARQKIFEPFSRLDDSRDRSTGGFGLGLAIVRR 399
Cdd:cd16922 5 LLNLLGNAIKfteegEVTLRVS-LEEEEEDGVQLRfsVEDTGIGIPEEQQARLFEPFSQADSSTTRKYGGTGLGLAISKK 83
|
90 100
....*....|....*....|....
gi 489178403 400 VAQWHGGYAEALETPQGGASFRLT 423
Cdd:cd16922 84 LVELMGGDISVESEPGQGSTFTFT 107
|
|
| HATPase_EnvZ-like |
cd16950 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
323-422 |
1.57e-19 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli EnvZ and Pseudomonas aeruginosa BfmS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli EnvZ of the EnvZ-OmpR two-component regulatory system (TCS), which functions in osmoregulation. It also contains the HATPase domain of Pseudomonas aeruginosa BfmS, the HK of the BfmSR TCS, which functions in the regulation of the rhl quorum-sensing system and bacterial virulence in P. aeruginosa. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a periplasmic domain.
Pssm-ID: 340426 [Multi-domain] Cd Length: 101 Bit Score: 83.27 E-value: 1.57e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489178403 323 MARAVINLLRNAIRHAHSRVEIALLDQGDSCQIRVNDDGPGIPADARQKIFEPFSRLDDSRDrsTGGFGLGLAIVRRVAQ 402
Cdd:cd16950 1 LKRVLSNLVDNALRYGGGWVEVSSDGEGNRTRIQVLDNGPGIAPEEVDELFQPFYRGDNARG--TSGTGLGLAIVQRISD 78
|
90 100
....*....|....*....|
gi 489178403 403 WHGGYAEALETPQGGASFRL 422
Cdd:cd16950 79 AHGGSLTLANRAGGGLCARI 98
|
|
| NtrB |
COG3852 |
Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms]; |
197-422 |
4.55e-19 |
|
Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms];
Pssm-ID: 443061 [Multi-domain] Cd Length: 361 Bit Score: 87.98 E-value: 4.55e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489178403 197 QMADRIESLisnqRELTNAVSHELRTPIS--RLSfeLEQLNKQVDAEVRHDLIEDMRADLGELEEMVSELLTYARLEHGn 274
Cdd:COG3852 127 RRAEKLAAV----GELAAGLAHEIRNPLTgiRGA--AQLLERELPDDELREYTQLIIEEADRLNNLVDRLLSFSRPRPP- 199
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489178403 275 vgsHREIVDAASWLDSVVADVALEAeAAGVTCEISACQ-VEQIRIEPRFMARAVINLLRNAI-------------RHAHs 340
Cdd:COG3852 200 ---EREPVNLHEVLERVLELLRAEA-PKNIRIVRDYDPsLPEVLGDPDQLIQVLLNLVRNAAeampeggtitirtRVER- 274
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489178403 341 RVEIALLDQGDSCQIRVNDDGPGIPADARQKIFEPF--SRlddsrdrsTGGFGLGLAIVRRVAQWHGGYAEALETPQGGA 418
Cdd:COG3852 275 QVTLGGLRPRLYVRIEVIDNGPGIPEEILDRIFEPFftTK--------EKGTGLGLAIVQKIVEQHGGTIEVESEPGKGT 346
|
....
gi 489178403 419 SFRL 422
Cdd:COG3852 347 TFRI 350
|
|
| CitA |
COG3290 |
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction ... |
221-423 |
6.35e-19 |
|
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction mechanisms];
Pssm-ID: 442519 [Multi-domain] Cd Length: 389 Bit Score: 87.98 E-value: 6.35e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489178403 221 RTPISRLSFELEQLNKQVDA--EVRHD----------LIEDMRADlgELEEMVSELLtyARLEHGNVGSHREIVDAAswL 288
Cdd:COG3290 173 RTELERLEEELEGVKELAEAlrAQRHDfrnhlhtisgLLQLGEYD--EALEYIDEIS--EELQELIDSLLSRIGNPV--L 246
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489178403 289 DSVVADVALEAEAAGVTCEISA-CQVEQIRIEPRFMARAVINLLRNAIRHA------HSRVEIALLDQGDSCQIRVNDDG 361
Cdd:COG3290 247 AALLLGKAARARERGIDLTIDIdSDLPDLPLSDTDLVTILGNLLDNAIEAVeklpeeERRVELSIRDDGDELVIEVEDSG 326
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 489178403 362 PGIPADARQKIFEP--FSRLDDSRdrstggfGLGLAIVRRVAQWHGGYAEALETPQGGASFRLT 423
Cdd:COG3290 327 PGIPEELLEKIFERgfSTKLGEGR-------GLGLALVKQIVEKYGGTIEVESEEGEGTVFTVR 383
|
|
| PRK09303 |
PRK09303 |
histidine kinase; |
112-423 |
2.34e-18 |
|
histidine kinase;
Pssm-ID: 236462 [Multi-domain] Cd Length: 380 Bit Score: 86.16 E-value: 2.34e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489178403 112 RIDAGPQLldIKLPPEPsltplftvlayilLGVLVGIALL----VWVrPHWRDLETLRL---AAQRFGDGDLSSRT-RIF 183
Cdd:PRK09303 65 RLVATPAL--IKISPEP-------------RQVLAGSNIFqqlkNWW-PRWQQEGATYSglgENLQPSEIDSGRYSqELL 128
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489178403 184 RRSD-IRTLAQHFNQMADRIESlisnQRELTNAVSHELRTPISRLSFELE--QLNKQVD-----AEVRHDLIEDMRADLG 255
Cdd:PRK09303 129 QLSDeLFVLRQENETLLEQLKF----KDRVLAMLAHDLRTPLTAASLALEtlELGQIDEdtelkPALIEQLQDQARRQLE 204
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489178403 256 ELEEMVSELLTYARLEHGNVGSHREIVDaaswLDSVVADVALEAEaagvtceiSACQVEQIRIE-------------PRF 322
Cdd:PRK09303 205 EIERLITDLLEVGRTRWEALRFNPQKLD----LGSLCQEVILELE--------KRWLAKSLEIQtdipsdlpsvyadQER 272
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489178403 323 MARAVINLLRNAIRH--AHSRVEIALLDQGDS-CQIRVNDDGPGIPADARQKIFEPFSRLDdsRDRSTGGFGLGLAIVRR 399
Cdd:PRK09303 273 IRQVLLNLLDNAIKYtpEGGTITLSMLHRTTQkVQVSICDTGPGIPEEEQERIFEDRVRLP--RDEGTEGYGIGLSVCRR 350
|
330 340
....*....|....*....|....
gi 489178403 400 VAQWHGGYAEALETPQGGASFRLT 423
Cdd:PRK09303 351 IVRVHYGQIWVDSEPGQGSCFHFT 374
|
|
| HATPase_PhoQ-like |
cd16954 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
329-423 |
4.98e-18 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG. PhoQ is the histidine kinase (HK) of the PhoP-PhoQ two-component regulatory system (TCS), which responds to the levels of Mg2+ and Ca2+, controls virulence, mediates the adaptation to Mg2+-limiting environments, and regulates numerous cellular activities. Providencia stuartii AarG is a putative sensor kinase which controls the expression of the 2'-N-acetyltransferase and an intrinsic multiple antibiotic resistance (Mar) response in Providencia stuartii. The AarG product is similar to PhoQ in that it is able to restore wild-type levels of resistance to a Salmonella typhimurium phoQ mutant. However, the expression of the 2'-N-acetyltransferase gene and of aarP (a gene encoding a transcriptional activator of 2'-N-acetyltransferase) are not significantly affected by the levels of Mg2+ or Ca2+. Most proteins in this group contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have an accessory HAMP sensor domain, and some have an intracellular membrane -interaction PhoQ sensor domain.
Pssm-ID: 340430 [Multi-domain] Cd Length: 135 Bit Score: 79.98 E-value: 4.98e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489178403 329 NLLRNAIRHAHSRVEIALLDQGDSCQIRVNDDGPGIPADARQKIFEPFSRLDDSRDrstgGFGLGLAIVRRVAQWHGGYA 408
Cdd:cd16954 44 NLLDNACKWCLEFVEVTARQTDGGLHLIVDDDGPGVPESQRSKIFQRGQRLDEQRP----GQGLGLAIAKEIVEQYGGEL 119
|
90
....*....|....*
gi 489178403 409 EALETPQGGASFRLT 423
Cdd:cd16954 120 SLSDSPLGGARFEVV 134
|
|
| HATPase_BasS-like |
cd16940 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
326-417 |
6.14e-18 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BasS HK of the BasS-BasR two-component regulatory system (TCS). Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some contain a HAMP sensory domain, while some an N-terminal two-component sensor kinase domain.
Pssm-ID: 340417 [Multi-domain] Cd Length: 113 Bit Score: 78.99 E-value: 6.14e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489178403 326 AVINLLRNAIRH--AHSRVEIALlDQGDSCQIRVNDDGPGIPADARQKIFEPFSRLDdsrDRSTGGFGLGLAIVRRVAQW 403
Cdd:cd16940 17 LLRNLVDNAVRYspQGSRVEIKL-SADDGAVIRVEDNGPGIDEEELEALFERFYRSD---GQNYGGSGLGLSIVKRIVEL 92
|
90
....*....|....
gi 489178403 404 HGGYAEALETPQGG 417
Cdd:cd16940 93 HGGQIFLGNAQGGG 106
|
|
| TMAO_torS |
TIGR02956 |
TMAO reductase sytem sensor TorS; This protein, TorS, is part of a regulatory system for the ... |
215-428 |
6.61e-18 |
|
TMAO reductase sytem sensor TorS; This protein, TorS, is part of a regulatory system for the torCAD operon that encodes the pterin molybdenum cofactor-containing enzyme trimethylamine-N-oxide (TMAO) reductase (TorA), a cognate chaperone (TorD), and a penta-haem cytochrome (TorC). TorS works together with the inducer-binding protein TorT and the response regulator TorR. TorS contains histidine kinase ATPase (pfam02518), HAMP (pfam00672), phosphoacceptor (pfam00512), and phosphotransfer (pfam01627) domains and a response regulator receiver domain (pfam00072). [Signal transduction, Two-component systems]
Pssm-ID: 274362 [Multi-domain] Cd Length: 968 Bit Score: 86.37 E-value: 6.61e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489178403 215 AVSHELRTPISRLSFELEQL-NKQVDAEVRHDLieDMRADLGE-LEEMVSELLTYARLEHGNVGSHREIVDAASWLDSVV 292
Cdd:TIGR02956 470 TMSHEIRTPLNGILGTLELLgDTGLTSQQQQYL--QVINRSGEsLLDILNDILDYSKIEAGHLSISPRPFDLNALLDDVH 547
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489178403 293 ADVALEAEAAGVTC--EISACQVEQIRIEPRFMARAVINLLRNAIRHAHS---RVEIALLDQGDsCQIRVNDDGPGIPAD 367
Cdd:TIGR02956 548 HLMVSRAQLKGIQLrlNIPEQLPNWWQGDGPRIRQVLINLVGNAIKFTDRgsvVLRVSLNDDSS-LLFEVEDTGCGIAEE 626
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 489178403 368 ARQKIFEPFSRLDDSrdRSTGGFGLGLAIVRRVAQWHGGYAEALETPQGGASFRLTWERPR 428
Cdd:TIGR02956 627 EQATLFDAFTQADGR--RRSGGTGLGLAISQRLVEAMDGELGVESELGVGSCFWFTLPLTR 685
|
|
| HATPase_VanS-like |
cd16923 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
323-410 |
6.84e-17 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Enterococcus faecium VanS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Enterococcus faecium VanS HK of the VanS-VanR two-component regulatory system (TCS) which activates the transcription of vanH, vanA and vanX vancomycin resistance genes. It also contains Ecoli YedV and PcoS, probable members of YedW-YedV TCS and PcoS-PcoR TCS, repectively. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); most also have a HAMP sensor domain.
Pssm-ID: 340400 [Multi-domain] Cd Length: 102 Bit Score: 75.89 E-value: 6.84e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489178403 323 MARAVINLLRNAIRHA--HSRVEIALLDQGDSCQIRVNDDGPGIPADARQKIFEPFSRLDDSRDrsTGGFGLGLAIVRRV 400
Cdd:cd16923 1 LQRVFSNLLSNAIKYSpeNTRIYITSFLTDDVVNIMFKNPSSHPLDFKLEKLFERFYRGDNSRN--TEGAGLGLSIAKAI 78
|
90
....*....|
gi 489178403 401 AQWHGGYAEA 410
Cdd:cd16923 79 IELHGGSASA 88
|
|
| PRK15347 |
PRK15347 |
two component system sensor kinase; |
129-422 |
3.89e-16 |
|
two component system sensor kinase;
Pssm-ID: 237951 [Multi-domain] Cd Length: 921 Bit Score: 80.84 E-value: 3.89e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489178403 129 SLTPLFTVLAYILLGVLVGIALLVWV------RPHWRDLETLrlaaQRFGDGDLSSRTRIFRRSDIRTLAQHFNQMADRI 202
Cdd:PRK15347 291 ALKPALQQLPFALLILVLLTSVLFLLlrrylaKPLWRFVDII----NKTGPAALEPRLPENRLDELGSIAKAYNQLLDTL 366
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489178403 203 ESLISN-----------------QRELTNA--------VSHELRTPISRLSFELEQL-NKQVDAEvRHDLIEDMRADLGE 256
Cdd:PRK15347 367 NEQYDTlenkvaertqalaeakqRAEQANKrksehlttISHEIRTPLNGVLGALELLqNTPLTAE-QMDLADTARQCTLS 445
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489178403 257 LEEMVSELLTYARLEHGNVGSHREIVDAASWLDSVVADVALEAEAAGVT--CEISACQVEQIRIEPRFMARAVINLLRNA 334
Cdd:PRK15347 446 LLAIINNLLDFSRIESGQMTLSLEETALLPLLDQAMLTIQGPAQSKSLTlrTFVGAHVPLYLHLDSLRLRQILVNLLGNA 525
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489178403 335 IRHA-HSRVEIALLDQGDSCQIRVNDDGPGIPADARQKIFEPFSRLDDsrdrSTGGFGLGLAIVRRVAQWHGGYAEALET 413
Cdd:PRK15347 526 VKFTeTGGIRLRVKRHEQQLCFTVEDTGCGIDIQQQQQIFTPFYQADT----HSQGTGLGLTIASSLAKMMGGELTLFST 601
|
....*....
gi 489178403 414 PQGGASFRL 422
Cdd:PRK15347 602 PGVGSCFSL 610
|
|
| HATPase_HupT_MifS-like |
cd16976 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
327-422 |
9.36e-16 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhodobacter capsulatus HupT and Pseudomonas aeruginosa MifS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Rhodobacter capsulatus HupT of the HupT-HupR two-component regulatory system (TCS), which regulates the synthesis of HupSL, a membrane bound [NiFe]hydrogenase. It also contains the HATPase domain of Pseudomonas aeruginosa MifS, the HK of the MifS-MifR TCS, which may be involved in sensing alpha-ketoglutarate and regulating its transport and subsequent metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some also have a C-terminal PAS sensor domain.
Pssm-ID: 340435 [Multi-domain] Cd Length: 102 Bit Score: 72.49 E-value: 9.36e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489178403 327 VINLLRNAIRHAHS----RVEIALLDQGDSCQIRVNDDGPGIPADARQKIFEPFsrlddSRDRSTG-GFGLGLAIVRRVA 401
Cdd:cd16976 5 LMNLLQNALDAMGKvenpRIRIAARRLGGRLVLVVRDNGPGIAEEHLSRVFDPF-----FTTKPVGkGTGLGLSISYGIV 79
|
90 100
....*....|....*....|.
gi 489178403 402 QWHGGYAEALETPQGGASFRL 422
Cdd:cd16976 80 EEHGGRLSVANEEGAGARFTF 100
|
|
| HATPase_FilI-like |
cd16921 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
329-423 |
2.00e-15 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Methanosaeta harundinacea FilI and some hybrid sensor histidine kinases; This family includes FilI, the histidine kinase (HK) component of FilI-FilRs, a two-component signal transduction system (TCS) of the methanogenic archaeon, Methanosaeta harundinacea, which is involved in regulating methanogenesis. The cytoplasmic HK core consists of a C-terminal HK-like ATPase domain (represented here) and a histidine kinase dimerization and phosphoacceptor domain (HisKA) domain, which, in FilI, are coupled to CHASE, HAMP, PAS, and GAF sensor domains. FilI-FilRs catalyzes the phosphotransfer between FilI (HK) and FilRs (FilR1 and FilR2, response regulators) of the TCS. TCSs are predicted to be of bacterial origin, and acquired by archaea by horizontal gene transfer. This model also includes related HATPase domains such as that of Synechocystis sp. PCC6803 phytochrome-like protein Cph1. Proteins having this HATPase domain and HisKA domain also have accessory sensor domains such as CHASE, GAF, HAMP and PAS; some are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340398 [Multi-domain] Cd Length: 105 Bit Score: 71.59 E-value: 2.00e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489178403 329 NLLRNAIRHAHSR----VEIALLDQGDSCQIRVNDDGPGIPADARQKIFEPFSRLdDSRDRStGGFGLGLAIVRRVAQWH 404
Cdd:cd16921 7 NLLGNAIKFRRPRrpprIEVGAEDVGEEWTFYVRDNGIGIDPEYAEKVFGIFQRL-HSREEY-EGTGVGLAIVRKIIERH 84
|
90
....*....|....*....
gi 489178403 405 GGYAEALETPQGGASFRLT 423
Cdd:cd16921 85 GGRIWLESEPGEGTTFYFT 103
|
|
| PRK11466 |
PRK11466 |
hybrid sensory histidine kinase TorS; Provisional |
62-422 |
3.13e-15 |
|
hybrid sensory histidine kinase TorS; Provisional
Pssm-ID: 236914 [Multi-domain] Cd Length: 914 Bit Score: 78.02 E-value: 3.13e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489178403 62 RQRQLEDWRPHYGLELSLTDARQAK----LTQEE-------QALLDKNLlvvrEDFTEFISRIDAgpQLLDIKLPPEPSL 130
Cdd:PRK11466 246 RQIRIEDPGVRAQVATTLTTVSQYSdllaLYQQDseisnhlQTLAQNNI----AQFAQFSSEVSQ--LVDTIELRNQHGL 319
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489178403 131 TPL-----FTVLAYILLGV--LVGIALLVW---VRPHWRDLETLRLAAQRFGDGDLSS---------------RTRIFRR 185
Cdd:PRK11466 320 AHLekasaRGQYSLLLLGMvsLCALILILWrvvYRSVTRPLAEQTQALQRLLDGDIDSpfpetagvreldtigRLMDAFR 399
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489178403 186 SDIRTLAQHFNQMADRIESLISNQRELT---------------------NAVSHELRTPISRLSFELEQL-NKQVDAEVR 243
Cdd:PRK11466 400 SNVHALNRHREQLAAQVKARTAELQELViehrqaraeaekasqaksaflAAMSHEIRTPLYGILGTAQLLaDNPALNAQR 479
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489178403 244 hdliEDMRA--DLGE-LEEMVSELLTYARLEHG--NVGSHREIVDAASWLDSVV--ADVALEAEAAGVTCEISACQVEQI 316
Cdd:PRK11466 480 ----DDLRAitDSGEsLLTILNDILDYSAIEAGgkNVSVSDEPFEPRPLLESTLqlMSGRVKGRPIRLATDIADDLPTAL 555
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489178403 317 RIEPRFMARAVINLLRNAIRHAhSRVEIALLDQGDSCQ--IRVNDDGPGIPADARQKIFEPFSRLDDSRdrstGGFGLGL 394
Cdd:PRK11466 556 MGDPRRIRQVITNLLSNALRFT-DEGSIVLRSRTDGEQwlVEVEDSGCGIDPAKLAEIFQPFVQVSGKR----GGTGLGL 630
|
410 420
....*....|....*....|....*...
gi 489178403 395 AIVRRVAQWHGGYAEALETPQGGASFRL 422
Cdd:PRK11466 631 TISSRLAQAMGGELSATSTPEVGSCFCL 658
|
|
| HATPase_DpiB-CitA-like |
cd16915 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
329-423 |
1.01e-14 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 DpiB, DcuS, and Bacillus subtilis CitS, DctS, and YufL; This family includes histidine kinase-like ATPase domains of Escherichia coli K-12 DpiB and DcuS, and Bacillus subtilis CitS, DctS and MalK histidine kinases (HKs) all of which are two component transduction systems (TCSs). E. coli K-12 DpiB (also known as CitA) is the histidine kinase (HK) of DpiA-DpiB, a two-component signal transduction system (TCS) required for the expression of citrate-specific fermentation genes and genes involved in plasmid inheritance. E. coli K-12 DcuS (also known as YjdH) is the HK of DcuS-DcuR, a TCS that in the presence of the extracellular C4-dicarboxlates, activates the expression of the genes of anaerobic fumarate respiration and of aerobic C4-dicarboxylate uptake. CitS is the HK of Bacillus subtilis CitS-CitT, a TCS which regulates expression of CitM, the Mg-citrate transporter. Bacillus subtilis DctS forms a tripartite sensor unit (DctS/DctA/DctB) for sensing C4 dicarboxylates. Bacillus subtilis MalK (also known as YfuL) is the HK of MalK-MalR (YufL-YufM) a TCS which regulates the expression of the malate transporters MaeN (YufR) and YflS, and is essential for utilization of malate in minimal medium. Proteins having this DpiB-CitA-like HATPase domain generally have sensor domains such as Cache and PAS, and a histidine kinase A (HisKA)-like SpoOB-type, alpha-helical domain.
Pssm-ID: 340392 [Multi-domain] Cd Length: 104 Bit Score: 69.62 E-value: 1.01e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489178403 329 NLLRNAI------RHAHSRVEIALLDQGDSCQIRVNDDGPGIPADARQKIFEP-FSrlddsrDRSTGGFGLGLAIVRRVA 401
Cdd:cd16915 7 NLIDNALdalaatGAPNKQVEVFLRDEGDDLVIEVRDTGPGIAPELRDKVFERgVS------TKGQGERGIGLALVRQSV 80
|
90 100
....*....|....*....|..
gi 489178403 402 QWHGGYAEALETPQGGASFRLT 423
Cdd:cd16915 81 ERLGGSITVESEPGGGTTFSIR 102
|
|
| HATPase_CreC-like |
cd16945 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
319-420 |
1.98e-14 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CreC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli CreC of the CreC-CreB two-component regulatory system (TCS) involved in catabolic regulation. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and accessory sensory domain(s) such as HAMP, CACHE or PAS.
Pssm-ID: 340421 [Multi-domain] Cd Length: 106 Bit Score: 69.03 E-value: 1.98e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489178403 319 EPRFMARAVINLLRNAIRHAHSRVEIALLDQ--GDSCQIRVNDDGPGIPADARQKIFEPFSRL--DDSRDRSTggfGLGL 394
Cdd:cd16945 1 DPFLLRQAINNLLDNAIDFSPEGGLIALQLEadTEGIELLVFDEGSGIPDYALNRVFERFYSLprPHSGQKST---GLGL 77
|
90 100
....*....|....*....|....*.
gi 489178403 395 AIVRRVAQWHGGYAEALETPQGGASF 420
Cdd:cd16945 78 AFVQEVAQLHGGRITLRNRPDGVLAF 103
|
|
| PRK11360 |
PRK11360 |
two-component system sensor histidine kinase AtoS; |
175-422 |
2.46e-14 |
|
two-component system sensor histidine kinase AtoS;
Pssm-ID: 236901 [Multi-domain] Cd Length: 607 Bit Score: 75.00 E-value: 2.46e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489178403 175 DLSSRTRIFRRsdirtLAQhfnqmADRIESLisnqRELTNAVSHELRTPISRLSFELEQLNKQVDAEVRHDLIEDMRADL 254
Cdd:PRK11360 370 DLTERKRLQRR-----VAR-----QERLAAL----GELVAGVAHEIRNPLTAIRGYVQIWRQQTSDPPSQEYLSVVLREV 435
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489178403 255 GELEEMVSELLTYARlehgnvgsHREIVDAASWLDSVVADVALEAEAAGVTCEI---SACQ--VEQIRIEPRFMARAVIN 329
Cdd:PRK11360 436 DRLNKVIDQLLEFSR--------PRESQWQPVSLNALVEEVLQLFQTAGVQARVdfeTELDneLPPIWADPELLKQVLLN 507
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489178403 330 LLRNAIRhAHS-----RVEIALLDQGDSCqIRVNDDGPGIPADARQKIFEPFSRLDDSrdrstgGFGLGLAIVRRVAQWH 404
Cdd:PRK11360 508 ILINAVQ-AISargkiRIRTWQYSDGQVA-VSIEDNGCGIDPELLKKIFDPFFTTKAK------GTGLGLALSQRIINAH 579
|
250
....*....|....*...
gi 489178403 405 GGYAEALETPQGGASFRL 422
Cdd:PRK11360 580 GGDIEVESEPGVGTTFTL 597
|
|
| HATPase_TmoS-FixL-DctS-like |
cd16920 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
327-423 |
2.96e-14 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhizobium meliloti FixL, and Rhodobacter capsulatus DctS; includes hybrid sensor histidine kinase similar to Pseudomonas mendocina TmoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs), such as Pseudomonas mendocina TmoS HK of the TmoS-TmoT TCS, which controls the expression of the toluene-4-monooxygenase pathway, Rhizobium meliloti FixL HK of the FixL-FixJ TCS, which regulates the expression of the genes related to nitrogen fixation in the root nodule in response to O(2) levels, and Rhodobacter capsulatus DctS of the DctS-DctR TCS, which controls synthesis of the high-affinity C4-dicarboxylate transport system. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and PAS sensor domain(s); many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340397 [Multi-domain] Cd Length: 104 Bit Score: 68.58 E-value: 2.96e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489178403 327 VINLLRNAI---RHAHSRVEIALL----DQGDSCQIRVNDDGPGIPADARQKIFEPFSRLDDSrdrstgGFGLGLAIVRR 399
Cdd:cd16920 5 LINLVRNGIeamSEGGCERRELTIrtspADDRAVTISVKDTGPGIAEEVAGQLFDPFYTTKSE------GLGMGLSICRS 78
|
90 100
....*....|....*....|....
gi 489178403 400 VAQWHGGYAEALETPQGGASFRLT 423
Cdd:cd16920 79 IIEAHGGRLSVESPAGGGATFQFT 102
|
|
| KinA |
COG5805 |
Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle ... |
211-406 |
5.70e-14 |
|
Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444507 [Multi-domain] Cd Length: 496 Bit Score: 73.61 E-value: 5.70e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489178403 211 ELTNAVSHELRTPISRLS--FELEQLNKqvdaEVRHDLIEDMRADLGELEEMVSELLTYARlehgNVGSHREIVDaaswL 288
Cdd:COG5805 289 QLAAGIAHEIRNPLTSIKgfLQLLQPGI----EDKEEYFDIMLSELDRIESIISEFLALAK----PQAVNKEKEN----I 356
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489178403 289 DSVVADVA--LEAEAAGVTCEISA----------CQVEQIRieprfmaRAVINLLRNAIRHAHS--RVEIALLDQGDSCQ 354
Cdd:COG5805 357 NELIQDVVtlLETEAILHNIQIRLelldedpfiyCDENQIK-------QVFINLIKNAIEAMPNggTITIHTEEEDNSVI 429
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|..
gi 489178403 355 IRVNDDGPGIPADARQKIFEPFSRLDDSrdrstgGFGLGLAIVRRVAQWHGG 406
Cdd:COG5805 430 IRVIDEGIGIPEERLKKLGEPFFTTKEK------GTGLGLMVSYKIIENHNG 475
|
|
| PRK10364 |
PRK10364 |
two-component system sensor histidine kinase ZraS; |
212-422 |
4.10e-13 |
|
two-component system sensor histidine kinase ZraS;
Pssm-ID: 236674 [Multi-domain] Cd Length: 457 Bit Score: 70.59 E-value: 4.10e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489178403 212 LTNAVSHELRTPISRLSFELEQLNKQVDAEVR-HDLIEDMRADLGELEEMVSELLTYARLEHGNVgshrEIVDAASWLDS 290
Cdd:PRK10364 240 LAAGVAHEIRNPLSSIKGLAKYFAERAPAGGEaHQLAQVMAKEADRLNRVVSELLELVKPTHLAL----QAVDLNDLINH 315
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489178403 291 VVADVALEAEAAGVTCEISACQ-VEQIRIEPRFMARAVINLLRNAIrHA---HSRVEIALLDQGDSCQIRVNDDGPGIPA 366
Cdd:PRK10364 316 SLQLVSQDANSREIQLRFTANDtLPEIQADPDRLTQVLLNLYLNAI-QAigqHGVISVTASESGAGVKISVTDSGKGIAA 394
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*..
gi 489178403 367 DARQKIFEP-FSRLDDsrdrstgGFGLGLAIVRRVAQWHGGYAEALETPQGGASFRL 422
Cdd:PRK10364 395 DQLEAIFTPyFTTKAE-------GTGLGLAVVHNIVEQHGGTIQVASQEGKGATFTL 444
|
|
| YesM |
COG2972 |
Sensor histidine kinase YesM [Signal transduction mechanisms]; |
129-399 |
5.05e-13 |
|
Sensor histidine kinase YesM [Signal transduction mechanisms];
Pssm-ID: 442211 [Multi-domain] Cd Length: 445 Bit Score: 70.43 E-value: 5.05e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489178403 129 SLTPLFTVLAYILLGVLVGIALLVWVRPHwRDLETLRLAAQRFGDGDLSsRTRIFRRSDIRTLAQHFNQMADRIESLISN 208
Cdd:COG2972 154 SLRRLILLIILLLLLLALLLSYLLSRSIT-RPIKRLKKAMKKVEKGDLV-RLEVSGNDEIGILARSFNEMVERIKELIEE 231
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489178403 209 QRELTnavshelrtpISRLSFELEQLNKQVDaevRHDL------IEDM--RADLGELEEMVSELLTYARLehgNVGSHRE 280
Cdd:COG2972 232 VYELE----------LEKKEAELKALQAQIN---PHFLfntlnsIRWLaeLEDPEEAEEMLEALSKLLRY---SLSKGDE 295
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489178403 281 IVDAASWLDSVVADVALEAEAAG----VTCEISACqVEQIRIePRFMaraVINLLRNAIRHA------HSRVEIALLDQG 350
Cdd:COG2972 296 LVTLEEELELIKSYLEIQKLRFGdrleVEIEIDEE-LLDLLI-PKLI---LQPLVENAIEHGiepkegGGTIRISIRKEG 370
|
250 260 270 280
....*....|....*....|....*....|....*....|....*....
gi 489178403 351 DSCQIRVNDDGPGIPADARQKIFEPFSRLDDSRdrstggfGLGLAIVRR 399
Cdd:COG2972 371 DRLVITVEDNGVGMPEEKLEKLLEELSSKGEGR-------GIGLRNVRE 412
|
|
| KinE |
COG5809 |
Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome ... |
211-406 |
6.22e-12 |
|
Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444511 [Multi-domain] Cd Length: 489 Bit Score: 67.31 E-value: 6.22e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489178403 211 ELTNAVSHELRTPISRLSFELEQLNKQVDAEVRHdLIEDMRADLGELEEMVSELLTYARLEHGNVgshrEIVDaaswLDS 290
Cdd:COG5809 272 ELAAGIAHEIRNPLTSLKGFIQLLKDTIDEEQKT-YLDIMLSELDRIESIISEFLVLAKPQAIKY----EPKD----LNT 342
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489178403 291 VVADVA--LEAEA----AGVTCEISA------CQVEQIRieprfmaRAVINLLRNAI----RHAHSRVEIALLDQgDSCQ 354
Cdd:COG5809 343 LIEEVIplLQPQAllknVQIELELEDdipdilGDENQLK-------QVFINLLKNAIeampEGGNITIETKAEDD-DKVV 414
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....
gi 489178403 355 IRVNDDGPGIPADARQKIFEPFSrlddsrdrST--GGFGLGLAIVRRVAQWHGG 406
Cdd:COG5809 415 ISVTDEGCGIPEERLKKLGEPFY--------TTkeKGTGLGLMVSYKIIEEHGG 460
|
|
| HATPase_EcPhoR-like |
cd16952 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
326-420 |
6.66e-12 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoR; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli or Vibrio cholera PhoR, the histidine kinase (HK) of PhoB-PhoR a two-component signal transduction system (TCS) involved in phosphate regulation. PhoR monitors extracellular inorganic phosphate (Pi) availability and PhoB, the response regulator, regulates transcription of genes of the phosphate regulon. PhoR is a bifunctional histidine autokinase/phospho-PhoB phosphatase; in phosphate deficiency, it autophosphorylates and Pi is transferred to PhoB, and when environmental Pi is abundant, it removes the phosphoryl group from phosphorylated PhoB. Other roles of PhoB-PhoR TCS have been described, including motility, biofilm formation, intestinal colonization, and virulence in V. cholera. E.coli PhoR and Bacillus subtilis PhoR (whose HATPase domain belongs to a different family) sense very different signals in each bacterium. In E. coli the PhoR signal comes from phosphate transport mediated by the PstSCAB2 phosphate transporter and the PhoU chaperone-like protein while in B. subtilis, the PhoR activation signal comes from wall teichoic acid (WTA) metabolism.
Pssm-ID: 340428 [Multi-domain] Cd Length: 108 Bit Score: 61.83 E-value: 6.66e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489178403 326 AVINLLRNAIRHAHSRVEIALLDQGD--SCQIRVNDDGPGIPADARQKIFEPFSRLDDSRDRSTGGFGLGLAIVRRVAQW 403
Cdd:cd16952 4 AFSNLVSNAVKYTPPSDTITVRWSQEesGARLSVEDTGPGIPPEHIPRLTERFYRVDIERCRNTGGTGLGLAIVKHVMSR 83
|
90
....*....|....*..
gi 489178403 404 HGGYAEALETPQGGASF 420
Cdd:cd16952 84 HDARLLIASELGKGSRF 100
|
|
| HATPase_Glnl-NtrB-like |
cd16918 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
323-422 |
8.24e-12 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli GlnL (synonyms NtrB and NRII); This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs), similar to Escherichia coli GlnL/NtrB/NRII HK of the two-component regulatory system (TCS) GlnL/GlnG (NtrB-NtrC, or NRII-NRI), which regulates the transcription of genes encoding metabolic enzymes and permeases in response to carbon and nitrogen status in E. coli and related bacteria. Also included in this family are Rhodobacter capsulatus NtrB, Azospirillum brasilense NtrB, Vibrio alginolyticus NtrB, Rhizobium leguminosarum biovar phaseoli NtrB, and Herbaspirillum seropedicae NtrB. Escherichia coli GlnL/NtrB/NRII is both a kinase and a phosphatase, catalyzing the phosphorylation and dephosphorylation of GlnG/NtrC/NRI. The kinase and phosphatase activities of GlnL/NtrB/NRII are regulated by the PII signal transduction protein, which on binding to GlnL/NtrB/NRII, inhibits the kinase activity of GlnL/NtrB/NRII and activates the GlnL/NtrB/NRII phosphatase activity. Proteins having this HATPase domain also have a histidine kinase dimerization and phosphoacceptor domain (HisKA); some also contain PAS sensor domain(s).
Pssm-ID: 340395 [Multi-domain] Cd Length: 109 Bit Score: 61.65 E-value: 8.24e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489178403 323 MARAVINLLRNA------------IRHAHSR-VEIALLDQGDSCQIRVNDDGPGIPADARQKIFEPFSrldDSRDrstGG 389
Cdd:cd16918 1 LIQVFLNLVRNAaqalagsggeiiLRTRTQRqVTLGHPRHRLALRVSVIDNGPGIPPDLQDTIFYPMV---SGRE---NG 74
|
90 100 110
....*....|....*....|....*....|...
gi 489178403 390 FGLGLAIVRRVAQWHGGYAEALETPqGGASFRL 422
Cdd:cd16918 75 TGLGLAIAQNIVSQHGGVIECDSQP-GHTVFSV 106
|
|
| HATPase_AtoS-like |
cd16943 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
327-422 |
1.01e-10 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 AtoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Escherichia coli AtoS, an HK of the AtoS-AtoC TCS. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have accessory domains such as HAMP or PAS sensor domains or CBS-pair domains.
Pssm-ID: 340419 [Multi-domain] Cd Length: 105 Bit Score: 58.59 E-value: 1.01e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489178403 327 VINLLRNAIR--HAHSRVEIALLDQGDSCQIRVNDDGPGIPADARQKIFEPFSRLDDSRDrstgGFGLGLAIVRRVAQWH 404
Cdd:cd16943 8 LLNLLVNAAQamEGRGRITIRTWAHVDQVLIEVEDTGSGIDPEILGRIFDPFFTTKPVGE----GTGLGLSLSYRIIQKH 83
|
90
....*....|....*...
gi 489178403 405 GGYAEALETPQGGASFRL 422
Cdd:cd16943 84 GGTIRVASVPGGGTRFTI 101
|
|
| PRK10815 |
PRK10815 |
two-component system sensor histidine kinase PhoQ; |
139-426 |
1.03e-10 |
|
two-component system sensor histidine kinase PhoQ;
Pssm-ID: 182754 [Multi-domain] Cd Length: 485 Bit Score: 63.50 E-value: 1.03e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489178403 139 YILLGVLVGIALLVWVRPHW--RDLETLrlAAQrfgdgdlssrtrifrrsdIRTLAQHFNQMAD------------RIES 204
Cdd:PRK10815 195 YVLLANLLLVIPLLWLAAWWslRPIEAL--AKQ------------------VRELEEGEREQLDpnppreltslvrNLNR 254
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489178403 205 LISNQRE--------LTNaVSHELRTPISRLSFELEQL--NKQVDaevrhdlIED----MRADLGELEEMVSELLTYARL 270
Cdd:PRK10815 255 LLKNERErytkyrttLTD-LTHSLKTPLAVLQSTLRSLrsGKQMS-------VEQaepiMLEQISRISQQIGYYLHRASM 326
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489178403 271 EHGNVGSHREIVDAASWLDSVVADVALEAEAAGV--TCEISAcQVEQIRIEPRFMaRAVINLLRNAIRHAHSRVEIALLD 348
Cdd:PRK10815 327 RSEHNLLSRELHSVAPLLDNLTSALNKVYQRKGVniTLDISP-EITFVGEKNDFM-EVMGNVLDNACKYCLEFVEISARQ 404
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 489178403 349 QGDSCQIRVNDDGPGIPADARQKIFEPFSRLDDSRDrstgGFGLGLAIVRRVAQWHGGYAEALETPQGGASFRLTWER 426
Cdd:PRK10815 405 TDEHLHIVVEDDGPGIPESKRELIFDRGQRADTLRP----GQGLGLSVAREITEQYEGKISAGDSPLGGARMEVIFGR 478
|
|
| HisKA |
pfam00512 |
His Kinase A (phospho-acceptor) domain; dimerization and phospho-acceptor domain of histidine ... |
209-273 |
3.43e-10 |
|
His Kinase A (phospho-acceptor) domain; dimerization and phospho-acceptor domain of histidine kinases.
Pssm-ID: 459839 [Multi-domain] Cd Length: 66 Bit Score: 55.68 E-value: 3.43e-10
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 489178403 209 QRELTNAVSHELRTPISRLSFELEQLNKQVDAEVRHDLIEDMRADLGELEEMVSELLTYARLEHG 273
Cdd:pfam00512 2 KSEFLANLSHELRTPLTAIRGYLELLRDEKLDEEQREYLETILRSAERLLRLINDLLDLSRIEAG 66
|
|
| PRK13837 |
PRK13837 |
two-component system VirA-like sensor kinase; |
154-420 |
5.42e-10 |
|
two-component system VirA-like sensor kinase;
Pssm-ID: 237526 [Multi-domain] Cd Length: 828 Bit Score: 61.62 E-value: 5.42e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489178403 154 VRPHWRDLETLRLAAQRFGDGdlssrTRIFRRSDIRTLAQHFNQMADRIESLISnqreLTNAVSHELRTPISRLSFELE- 232
Cdd:PRK13837 404 LRPPAGELQLLELALDCLAHA-----IERRRLETERDALERRLEHARRLEAVGT----LASGIAHNFNNILGAILGYAEm 474
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489178403 233 QLNKQVDAEVRHDLIEDMRADLGELEEMVSELLTYARLEHGNVG--SHREIVDAASWLDSVV----ADVALEAEAAGVTC 306
Cdd:PRK13837 475 ALNKLARHSRAARYIDEIISAGARARLIIDQILAFGRKGERNTKpfDLSELVTEIAPLLRVSlppgVELDFDQDQEPAVV 554
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489178403 307 EISACQVEQIrieprfmaraVINLLRNAIR--HAHSRVEIAL---------------LDQGDSCQIRVNDDGPGIPADAR 369
Cdd:PRK13837 555 EGNPAELQQV----------LMNLCSNAAQamDGAGRVDISLsraklrapkvlshgvLPPGRYVLLRVSDTGAGIDEAVL 624
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|...
gi 489178403 370 QKIFEPF--SRlddsrdrsTGGFGLGLAIVRRVAQWHGGYAEALETPQGGASF 420
Cdd:PRK13837 625 PHIFEPFftTR--------AGGTGLGLATVHGIVSAHAGYIDVQSTVGRGTRF 669
|
|
| HATPase_NtrY-like |
cd16944 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
321-423 |
5.61e-10 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Azorhizobium caulinodans NtrY; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Azorhizobium caulinodans ORS571 NtrY of the NtrY-NtrX TCS, which is involved in nitrogen fixation and metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also have PAS sensor domains.
Pssm-ID: 340420 [Multi-domain] Cd Length: 108 Bit Score: 56.39 E-value: 5.61e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489178403 321 RFMARAVINLLRNAIRHAHSR----VEIAL---LDQGDSCQIRVNDDGPGIPADARQKIFEPFSRlddsrDRSTGgFGLG 393
Cdd:cd16944 3 TQISQVLTNILKNAAEAIEGRpsdvGEVRIrveADQDGRIVLIVCDNGKGFPREMRHRATEPYVT-----TRPKG-TGLG 76
|
90 100 110
....*....|....*....|....*....|
gi 489178403 394 LAIVRRVAQWHGGYAEALETPQGGASFRLT 423
Cdd:cd16944 77 LAIVKKIMEEHGGRISLSNREAGGACIRII 106
|
|
| PRK09959 |
PRK09959 |
acid-sensing system histidine kinase EvgS; |
193-423 |
7.01e-10 |
|
acid-sensing system histidine kinase EvgS;
Pssm-ID: 182169 [Multi-domain] Cd Length: 1197 Bit Score: 61.29 E-value: 7.01e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489178403 193 QHFNQMADRIESLISNQRELTNA----------VSHELRTPISRLSFELEQLNKQ-VDAEVRHDLIEDMRADLGELEEMV 261
Cdd:PRK09959 686 QDITETRDLIHALEVERNKAINAtvaksqflatMSHEIRTPISSIMGFLELLSGSgLSKEQRVEAISLAYATGQSLLGLI 765
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489178403 262 SELLTYARLEHGNVGSHREIVDAASWLDSVVADVALEAEAAGVTCEISACQVEQ--IRIEPRFMARAVINLLRNAIRHAH 339
Cdd:PRK09959 766 GEILDVDKIESGNYQLQPQWVDIPTLVQNTCHSFGAIAASKSIALSCSSTFPDHylVKIDPQAFKQVLSNLLSNALKFTT 845
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489178403 340 S---RVEIALLDQGDS---CQIRVNDDGPGIPADARQKIFEPFSRLDDSRDRStgGFGLGLAIVRRVAQWHGGYAEALET 413
Cdd:PRK09959 846 EgavKITTSLGHIDDNhavIKMTIMDSGSGLSQEEQQQLFKRYSQTSAGRQQT--GSGLGLMICKELIKNMQGDLSLESH 923
|
250
....*....|
gi 489178403 414 PQGGASFRLT 423
Cdd:PRK09959 924 PGIGTTFTIT 933
|
|
| HATPase_SpaK_NisK-like |
cd16975 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
325-422 |
9.21e-10 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK. SpaK is the histidine kinase (HK) of the SpaK-SpaR two-component regulatory system (TCS), which is involved in the regulation of the biosynthesis of lantibiotic subtilin. NisK is the HK of the NisK-NisR TCS, which is involved in the regulation of the biosynthesis of lantibiotic nisin. SpaK and NisK may function as membrane-associated protein kinases that phosphorylate SpaR and NisR, respectively, in response to environmental signals.
Pssm-ID: 340434 [Multi-domain] Cd Length: 107 Bit Score: 55.55 E-value: 9.21e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489178403 325 RAVINLLRNAIRHAHSR--VEIALLDQGDSCQIRVNDDGPGIPADARQKIFEPFSRLDDSRDrSTGGFGLGLAIVRRVAQ 402
Cdd:cd16975 7 RALINIISNACQYAPEGgtVSISIYDEEEYLYFEIWDNGHGFSEQDLKKALELFYRDDTSRR-SGGHYGMGLYIAKNLVE 85
|
90 100
....*....|....*....|
gi 489178403 403 WHGGYAEALETPQGGASFRL 422
Cdd:cd16975 86 KHGGSLIIENSQKGGAEVTV 105
|
|
| HisKA |
smart00388 |
His Kinase A (phosphoacceptor) domain; Dimerisation and phosphoacceptor domain of histidine ... |
209-273 |
3.35e-09 |
|
His Kinase A (phosphoacceptor) domain; Dimerisation and phosphoacceptor domain of histidine kinases.
Pssm-ID: 214644 [Multi-domain] Cd Length: 66 Bit Score: 52.95 E-value: 3.35e-09
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 489178403 209 QRELTNAVSHELRTPISRLSFELEQLNKQVDAEVRHDLIEDMRADLGELEEMVSELLTYARLEHG 273
Cdd:smart00388 2 KREFLANLSHELRTPLTAIRGYLELLLDTELSEEQREYLETILREAERLLRLINDLLDLSRIEAG 66
|
|
| HATPase_BvrS-ChvG-like |
cd16953 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
323-427 |
5.18e-09 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Brucella abortus BvrS and Sinorhizobium meliloti ChvG; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Brucella abortus BvrS of the BvrR-BvrS two-component regulatory system (TCS), which controls cell invasion and intracellular survival, as well as Sinorhizobium meliloti and Agrobacterium tumefaciens ChvG of the ChvI-ChvG TCS necessary for endosymbiosis and pathogenicity in plants. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), an accessory HAMP sensor domain, a periplasmic stimulus-sensing domain, and some also have a sensor N-terminal transmembrane domain.
Pssm-ID: 340429 [Multi-domain] Cd Length: 110 Bit Score: 53.73 E-value: 5.18e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489178403 323 MARAVINLLRNAIRHA---HSRVEIALLDQGDSCQIRVNDDGPGIPADARQKIFEPFSRLDDSRDRSTGGFGLGLAIVRR 399
Cdd:cd16953 1 LGQVLRNLIGNAISFSppdTGRITVSAMPTGKMVTISVEDEGPGIPQEKLESIFDRFYTERPANEAFGQHSGLGLSISRQ 80
|
90 100 110
....*....|....*....|....*....|
gi 489178403 400 VAQWHGG--YAEALETPQGGASFRLTWERP 427
Cdd:cd16953 81 IIEAHGGisVAENHNQPGQVIGARFTVQLP 110
|
|
| HAMP |
cd06225 |
Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain; ... |
154-202 |
5.51e-09 |
|
Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain; HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The structure of the Af1503 HAMP dimer from Archaeoglobus fulgidus has been solved using nuclear magnetic resonance, revealing a parallel four-helix bundle; this structure has been confirmed by cross-linking analysis of HAMP domains from the Escherichia coli aerotaxis receptor Aer. It has been suggested that the four-helix arrangement can rotate between the unusually packed conformation observed in the NMR structure and a canonical coiled-coil arrangement. Such rotation may coincide with signal transduction, but a common mechanism by which HAMP domains relay a variety of input signals has yet to be established.
Pssm-ID: 381743 [Multi-domain] Cd Length: 45 Bit Score: 51.68 E-value: 5.51e-09
10 20 30 40
....*....|....*....|....*....|....*....|....*....
gi 489178403 154 VRPhwrdLETLRLAAQRFGDGDLSSRTRIFRRSDIRTLAQHFNQMADRI 202
Cdd:cd06225 1 TRP----LRRLTEAARRIAEGDLDVRVPVRSKDEIGELARAFNQMAERL 45
|
|
| HATPase_YcbM-like |
cd16947 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
323-406 |
2.27e-08 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis YcbM; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis YcbM, a HK of the two-component system YcbM-YcbL. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA).
Pssm-ID: 340423 [Multi-domain] Cd Length: 125 Bit Score: 52.13 E-value: 2.27e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489178403 323 MARAVINLLRNAIRH--AHSRVEIALLDQGDSCQIRVNDDGPGIPADARQKIFEPFSRLDDSRDRSTGGFGLGLAIVRRV 400
Cdd:cd16947 21 LQRILKNLISNAIKYgsDGKFLGMTLREDEKHVYIDIWDKGKGISETEKDHVFERLYTLEDSRNSAKQGNGLGLTITKRL 100
|
....*.
gi 489178403 401 AQWHGG 406
Cdd:cd16947 101 AESMGG 106
|
|
| ArsS_fam_HK |
NF038389 |
ArsS family sensor histidine kinase; ArsS in Helicobacter pylori is a sensor histidine kinase ... |
139-405 |
2.35e-08 |
|
ArsS family sensor histidine kinase; ArsS in Helicobacter pylori is a sensor histidine kinase participating in a two-component system that controls the response to acid conditiions encountered during the process of gastric colonization. This HMM identified ArsS itself but also a broader collection of apparent orthologs from closely related non-gastric colonizers such as Helicobacter hepaticus, Campylobacter jejuni and Wolinella succinogenes. See BlastRule NBR014349 for specific identification of ArsS itself, distinguished by a signature His residue that becomes protonated at low pH.
Pssm-ID: 468500 [Multi-domain] Cd Length: 402 Bit Score: 55.62 E-value: 2.35e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489178403 139 YILLGVLVGIALL----VWVRPHWRDLETLRLAAQRFGDGDLSSRTRIFRRSDIRTLAQHFNQMADRIESLI-SNQRELT 213
Cdd:NF038389 132 YIIVFFIFLILLLlilyISVLKSLKPLKKLKKQIKKFANGDFDFIKSESNGDEIGEVANEFDKAVKKIKALNeSRQLFLR 211
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489178403 214 NaVSHELRTPI--SRLSFELEQLNKQVdaevrhdliEDMRADLGELEEMVSELLTYARLEHGNVGSHREIVDAASWLDSV 291
Cdd:NF038389 212 N-IMHELKTPItkGRIVAEMLEDEKQK---------ERLISIFERLESLINEFAKIEQLTSKNYKLNKKEYRLSDIIDEA 281
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489178403 292 VaDVALeAEAAGVTCEISacqVEQIRIEPRF--MARAVINLLRNAIRHAhsrveiallDQGDsCQIRVNDD-------GP 362
Cdd:NF038389 282 I-DMLM-IDDSSVIIKVS---LEDFKLNVDFelFSLAIKNLIDNAIKYS---------PDKK-VTIEIKGDkiefknkGE 346
|
250 260 270 280
....*....|....*....|....*....|....*....|...
gi 489178403 363 GIPADaRQKIFEPFSRlddSRDRSTGGFGLGLAIVRRVAQWHG 405
Cdd:NF038389 347 PLEEP-LEYYFEPFFK---GNEKSKSGFGLGLYIVKNILKAHG 385
|
|
| PRK10841 |
PRK10841 |
two-component system sensor histidine kinase RcsC; |
216-396 |
4.74e-08 |
|
two-component system sensor histidine kinase RcsC;
Pssm-ID: 182772 [Multi-domain] Cd Length: 924 Bit Score: 55.37 E-value: 4.74e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489178403 216 VSHELRTP----ISRLsfELEQ---LNKQVDAevrhdLIEDMRADLGELEEMVSELLTYARLEHGNVG------SHREIV 282
Cdd:PRK10841 454 VSHELRTPlygiIGNL--DLLQtkeLPKGVDR-----LVTAMNNSSSLLLKIISDILDFSKIESEQLKieprefSPREVI 526
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489178403 283 D--AASWLDSVVAdvaleaEAAGVTCEISACQVEQIRIEPRFMARAVINLLRNAIRHAHSR-VEIALLDQGDSCQIRVND 359
Cdd:PRK10841 527 NhiTANYLPLVVK------KRLGLYCFIEPDVPVALNGDPMRLQQVISNLLSNAIKFTDTGcIVLHVRVDGDYLSFRVRD 600
|
170 180 190
....*....|....*....|....*....|....*..
gi 489178403 360 DGPGIPADARQKIFEPFSRLDDSRDRSTGGFGLGLAI 396
Cdd:PRK10841 601 TGVGIPAKEVVRLFDPFFQVGTGVQRNFQGTGLGLAI 637
|
|
| ComP |
COG4585 |
Signal transduction histidine kinase ComP [Signal transduction mechanisms]; |
130-424 |
1.57e-07 |
|
Signal transduction histidine kinase ComP [Signal transduction mechanisms];
Pssm-ID: 443642 [Multi-domain] Cd Length: 252 Bit Score: 52.31 E-value: 1.57e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489178403 130 LTPLFTVLAYILLGVLVGIALLVWVRPHWRDLETLRLAAQRfgdgdlssrtrifRRSDIRTLAQHFNQMAdrieslisnq 209
Cdd:COG4585 2 LALALLGALALLVGALLGLLLALVLLRARRAERAAELEREL-------------AARAEEAREEERRRIA---------- 58
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489178403 210 RELTNAVSHELrtpiSRLSFELEQLNKQVDAEVrhdliEDMRADLGELEEMVSELLTYARlehGNVGSHREIVDAASWLD 289
Cdd:COG4585 59 RELHDGVGQSL----SAIKLQLEAARRLLDADP-----EAAREELEEIRELAREALAELR---RLVRGLRPPALDDLGLA 126
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489178403 290 SVVADVALEA-EAAGVTCEISaCQVEQIRIEPRFMA---RAVINLLRNAIRHAH-SRVEIALLDQGDSCQIRVNDDGPGI 364
Cdd:COG4585 127 AALEELAERLlRAAGIRVELD-VDGDPDRLPPEVELalyRIVQEALTNALKHAGaTRVTVTLEVDDGELTLTVRDDGVGF 205
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|
gi 489178403 365 PADARqkifepfsrlddsrdrSTGGFGLgLAIVRRVAQwHGGYAEALETPQGGASFRLTW 424
Cdd:COG4585 206 DPEAA----------------PGGGLGL-RGMRERAEA-LGGTLTIGSAPGGGTRVRATL 247
|
|
| HisKA |
cd00082 |
Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed ... |
209-269 |
2.98e-07 |
|
Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-autophosphorylation by the catalytic domain of the histidine kinase. They subsequently transfer the phosphoryl group to the Asp acceptor residue of a response regulator protein. Two-component signalling systems, consisting of a histidine protein kinase that senses a signal input and a response regulator that mediates the output, are ancient and evolutionarily conserved signaling mechanisms in prokaryotes and eukaryotes.
Pssm-ID: 119399 [Multi-domain] Cd Length: 65 Bit Score: 47.21 E-value: 2.98e-07
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 489178403 209 QRELTNAVSHELRTPISRLSFELEQL-NKQVDAEVRHDLIEDMRADLGELEEMVSELLTYAR 269
Cdd:cd00082 4 KGEFLANVSHELRTPLTAIRGALELLeEELLDDEEQREYLERIREEAERLLRLINDLLDLSR 65
|
|
| nifL_nitrog |
TIGR02938 |
nitrogen fixation negative regulator NifL; NifL is a modulator of the nitrogen fixation ... |
330-417 |
4.01e-07 |
|
nitrogen fixation negative regulator NifL; NifL is a modulator of the nitrogen fixation positive regulator protein NifA, and is therefore a negative regulator. It binds NifA. NifA and NifL are encoded by adjacent genes. [Central intermediary metabolism, Nitrogen fixation, Regulatory functions, Protein interactions]
Pssm-ID: 131984 [Multi-domain] Cd Length: 494 Bit Score: 52.21 E-value: 4.01e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489178403 330 LLRNAI----RHAHSRVEIALLD--QGDSCQIRVNDDGPGIPADARQKIFEPFSrldDSRDRSTGGFGLGLAIVRRVAQW 403
Cdd:TIGR02938 395 LVDNAIeamnIKGWKRRELSITTalNGDLIVVSILDSGPGIPQDLRYKVFEPFF---TTKGGSRKHIGMGLSVAQEIVAD 471
|
90
....*....|....
gi 489178403 404 HGGYAEALETPQGG 417
Cdd:TIGR02938 472 HGGIIDLDDDYSEG 485
|
|
| HAMP |
smart00304 |
HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; |
155-207 |
4.01e-07 |
|
HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain;
Pssm-ID: 197640 [Multi-domain] Cd Length: 53 Bit Score: 46.47 E-value: 4.01e-07
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|...
gi 489178403 155 RPHWRDLETLRLAAQRFGDGDLSSRTRIFRRSDIRTLAQHFNQMADRIESLIS 207
Cdd:smart00304 1 RRLLRPLRRLAEAAQRIADGDLTVRLPVDGRDEIGELARAFNEMADRLEETIA 53
|
|
| HAMP |
pfam00672 |
HAMP domain; |
154-203 |
4.04e-07 |
|
HAMP domain;
Pssm-ID: 459898 [Multi-domain] Cd Length: 53 Bit Score: 46.46 E-value: 4.04e-07
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|
gi 489178403 154 VRPHWRDLETLRLAAQRFGDGDLSSRTRIFRRSDIRTLAQHFNQMADRIE 203
Cdd:pfam00672 3 ARRILRPLRRLAEAARRIASGDLDVRLPVSGRDEIGELARAFNQMAERLR 52
|
|
| dpiB |
PRK15053 |
sensor histidine kinase DpiB; Provisional |
184-422 |
6.05e-07 |
|
sensor histidine kinase DpiB; Provisional
Pssm-ID: 185013 [Multi-domain] Cd Length: 545 Bit Score: 51.76 E-value: 6.05e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489178403 184 RRSDIRTLAQHFNQMADRiESLISNQRELTNAVSHELRTPISRLSFELEQLNKQVDA--EVRHDLIEDMRADLGELEemV 261
Cdd:PRK15053 286 KRQDVVANFNGLSVIANR-EAIRSGDDLLGAIISFRSKDEISTLNAQLTQIKQYVESlrTLRHEHLNWMSTLNGLLQ--M 362
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489178403 262 SELLTYARLEHGNVGSHREIVDA--ASWLDSVVADVAL----EAEAAGVTCEI-SACQVEQI--RIEPRFMARAVINLLR 332
Cdd:PRK15053 363 KEYDRVLEMVQGESQAQQQLIDSlrEAFADRQVAGLLFgkvqRARELGLKMVIvPGSQLSQLppGLDSTEFAAIVGNLLD 442
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489178403 333 NAI------RHAHSRVEIALLDQGDSCQIRVNDDGPGIPADARQKIFEpfsRLDDSRDRSTGGFGLGLAIVRRVAQWHGG 406
Cdd:PRK15053 443 NAFeaslrsDEGNKIVELFLSDEGDDVVIEVADQGCGVPESLRDKIFE---QGVSTRADEPGEHGIGLYLIASYVTRCGG 519
|
250
....*....|....*.
gi 489178403 407 YAEALETPQGGASFRL 422
Cdd:PRK15053 520 VITLEDNDPCGTLFSI 535
|
|
| RsbW |
COG2172 |
Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; |
292-401 |
8.56e-07 |
|
Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms];
Pssm-ID: 441775 [Multi-domain] Cd Length: 127 Bit Score: 47.60 E-value: 8.56e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489178403 292 VADVALEAEAAGVTCEISACQVEQIRIeprfmarAVINLLRNAIRHAHS-----RVEIALLDQGDSCQIRVNDDGPGIPa 366
Cdd:COG2172 11 LGLARRAVRALLRELGLDEDDADDLVL-------AVSEAVTNAVRHAYGgdpdgPVEVELELDPDGLEIEVRDEGPGFD- 82
|
90 100 110
....*....|....*....|....*....|....*
gi 489178403 367 darqkifePFSRLDDSRDRSTGgfGLGLAIVRRVA 401
Cdd:COG2172 83 --------PEDLPDPYSTLAEG--GRGLFLIRRLM 107
|
|
| Tar |
COG0840 |
Methyl-accepting chemotaxis protein (MCP) [Signal transduction mechanisms]; |
20-269 |
2.45e-06 |
|
Methyl-accepting chemotaxis protein (MCP) [Signal transduction mechanisms];
Pssm-ID: 440602 [Multi-domain] Cd Length: 533 Bit Score: 49.63 E-value: 2.45e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489178403 20 IFVVDHVIDAFYDSIVENYHRDAVRGQAYSLVEKLAPLDQAGRQRQLEDWRPHYGLELSLTDARQAKLTQEEQALLDKNL 99
Cdd:COG0840 68 VLLALLLLLALVVLLALLLALLLLLLALLALALAALALLAALAALLALLELLLAALLAALAIALLALAALLALAALALAL 147
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489178403 100 LVVREDFTEFISRIDAGPQLLDIKLPPEPSLTPLFTVLAYILLGVLVGIALLVWV-RPHWRDLETLRLAAQRFGDGDLSS 178
Cdd:COG0840 148 LALALLAAAAAAAAALAALLEAAALALAAAALALALLAAALLALVALAIILALLLsRSITRPLRELLEVLERIAEGDLTV 227
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489178403 179 RTRIFRRSDIRTLAQHFNQMADRIESLISNQRELTNAV---SHELRTPISRLSFELEQLNKQVDaEVRhDLIEDMRADLG 255
Cdd:COG0840 228 RIDVDSKDEIGQLADAFNRMIENLRELVGQVRESAEQVasaSEELAASAEELAAGAEEQAASLE-ETA-AAMEELSATVQ 305
|
250
....*....|....
gi 489178403 256 ELEEMVSELLTYAR 269
Cdd:COG0840 306 EVAENAQQAAELAE 319
|
|
| PRK11091 |
PRK11091 |
aerobic respiration control sensor protein ArcB; Provisional |
329-423 |
1.63e-05 |
|
aerobic respiration control sensor protein ArcB; Provisional
Pssm-ID: 236842 [Multi-domain] Cd Length: 779 Bit Score: 47.24 E-value: 1.63e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489178403 329 NLLRNAIRHAHS-----RVEIallDQGDSCQIRVNDDGPGIPADARQKIFEPFSRLDDSRD-RSTGGFGLGLAIVRRVAQ 402
Cdd:PRK11091 405 NLISNAVKFTQQggvtvRVRY---EEGDMLTFEVEDSGIGIPEDELDKIFAMYYQVKDSHGgKPATGTGIGLAVSKRLAQ 481
|
90 100
....*....|....*....|.
gi 489178403 403 WHGGYAEALETPQGGASFRLT 423
Cdd:PRK11091 482 AMGGDITVTSEEGKGSCFTLT 502
|
|
| HATPase_UhpB-NarQ-NarX-like |
cd16917 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
331-427 |
3.48e-05 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli UhpB, NarQ and NarX, and Bacillus subtilis YdfH, YhcY and YfiJ; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Escherichia coli UhpB, a HK of the UhpB-UhpA TCS, NarQ and NarX, HKs of the NarQ-NarP and NarX-NarL TCSs, respectively, and Bacillus YdfH, YhcY and YfiJ HKs, of the YdfH-YdfI, YhcY-YhcZ and YfiJ-YfiK TCSs, respectively. In addition, it includes Bacillus YxjM, ComP, LiaS and DesK, HKs of the YxjM-YxjML, ComP-ComA, LiaS-LiaR, DesR-DesK TCSs, respectively. Proteins having this HATPase domain have a histidine kinase dimerization and phosphoacceptor domain; some have accessory domains such as GAF, HAMP, PAS and MASE sensor domains.
Pssm-ID: 340394 [Multi-domain] Cd Length: 87 Bit Score: 42.16 E-value: 3.48e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489178403 331 LRNAIRHAH-SRVEIALLDQGDSCQIRVNDDGPGIPADARqkifepfsrlddsrdrsTGGFGLGLAIVR-RVAQWhGGYA 408
Cdd:cd16917 9 LTNALKHAGaSRVRVTLSYTADELTLTVVDDGVGFDGPAP-----------------PGGGGFGLLGMReRAELL-GGTL 70
|
90
....*....|....*....
gi 489178403 409 EALETPQGGasFRLTWERP 427
Cdd:cd16917 71 TIGSRPGGG--TRVTARLP 87
|
|
| HATPase_RsbW-like |
cd16936 |
Histidine kinase-like ATPase domain of RsbW, an anti sigma-B factor and serine-protein kinase ... |
330-401 |
8.51e-05 |
|
Histidine kinase-like ATPase domain of RsbW, an anti sigma-B factor and serine-protein kinase involved in regulating sigma-B during stress in Bacilli, and related domains; This family includes histidine kinase-like ATPase (HATPase) domain of RsbW, an anti sigma-B factor as well as a serine-protein kinase involved in regulating sigma-B during stress in Bacilli. The alternative sigma factor sigma-B is an important regulator of the general stress response of Bacillus cereus and B. subtilis. RsbW is an anti-sigma factor while RsbV is an anti-sigma factor antagonist (anti-anti-sigma factor). RsbW can also act as a kinase on RsbV. In a partner-switching mechanism, RsbW, RsbV, and sigma-B participate as follows: in non-stressed cells, sigma-B is present in an inactive form complexed with RsbW; in this form, sigma-B is unable to bind to RNA polymerase. Under stress, RsbV binds to RsbW, forming an RsbV-RsbW complex, and sigma-B is released to bind to RNA polymerase. RsbW may then act as a kinase on RsbV, phosphorylating a serine residue; RsbW is then released to bind to sigma-B, hence blocking its ability to bind RNA polymerase. A phosphatase then dephosphorylates RsbV so that it can again form a complex with RsbW, leading to the release of sigma-B.
Pssm-ID: 340413 [Multi-domain] Cd Length: 91 Bit Score: 41.10 E-value: 8.51e-05
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 489178403 330 LLRNAIRHAHS-----RVEIALLDQGDSCQIRVNDDGPGipadarqkiFEPFSRLDDSRDRSTGgfGLGLAIVRRVA 401
Cdd:cd16936 8 AVTNAVRHAYRhdgpgPVRLELDLDPDRLRVEVTDSGPG---------FDPLRPADPDAGLREG--GRGLALIRALM 73
|
|
| PRK11107 |
PRK11107 |
hybrid sensory histidine kinase BarA; Provisional |
327-406 |
8.88e-05 |
|
hybrid sensory histidine kinase BarA; Provisional
Pssm-ID: 236848 [Multi-domain] Cd Length: 919 Bit Score: 44.84 E-value: 8.88e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489178403 327 VINLLRNAIR-----HAHSRVEIALLDQgDSCQIR--VNDDGPGIPADARQKIFEPFSRLDDSRDRSTGGFGLGLAIVRR 399
Cdd:PRK11107 413 ITNLVGNAIKftesgNIDILVELRALSN-TKVQLEvqIRDTGIGISERQQSQLFQAFRQADASISRRHGGTGLGLVITQK 491
|
....*..
gi 489178403 400 VAQWHGG 406
Cdd:PRK11107 492 LVNEMGG 498
|
|
| HATPase_c_2 |
pfam13581 |
Histidine kinase-like ATPase domain; |
292-401 |
1.07e-04 |
|
Histidine kinase-like ATPase domain;
Pssm-ID: 433327 [Multi-domain] Cd Length: 127 Bit Score: 41.89 E-value: 1.07e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489178403 292 VADVALEAEAAGVTCEISACQVEQIRIeprfmarAVINLLRNAIRHAH-----SRVEIALLDQGDSCQIRVNDDGPgiPA 366
Cdd:pfam13581 8 LRAARRVLEAVLRRAGLPEELLDEVEL-------AVGEACTNAVEHAYregpeGPVEVRLTSDGGGLVVTVADSGP--PF 78
|
90 100 110
....*....|....*....|....*....|....*
gi 489178403 367 DARQKIFEPFSRLDDSRDRStggfGLGLAIVRRVA 401
Cdd:pfam13581 79 DPLTLPPPDLEEPDEDRKEG----GRGLALIRGLM 109
|
|
| PRK13557 |
PRK13557 |
histidine kinase; Provisional |
317-422 |
1.99e-04 |
|
histidine kinase; Provisional
Pssm-ID: 237425 [Multi-domain] Cd Length: 540 Bit Score: 43.51 E-value: 1.99e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489178403 317 RIEPRFMARAVINLLRNA-----------IR------HAHSRVEIALLDQGDSCQIRVNDDGPGIPADARQKIFEPFSRL 379
Cdd:PRK13557 272 RIDPTQAEVALLNVLINArdampeggrvtIRtrnveiEDEDLAMYHGLPPGRYVSIAVTDTGSGMPPEILARVMDPFFTT 351
|
90 100 110 120
....*....|....*....|....*....|....*....|...
gi 489178403 380 DDSRDrstgGFGLGLAIVRRVAQWHGGYAEALETPQGGASFRL 422
Cdd:PRK13557 352 KEEGK----GTGLGLSMVYGFAKQSGGAVRIYSEVGEGTTVRL 390
|
|
| HATPase_CckA-like |
cd16919 |
Histidine kinase-like ATPase domain of two-component sensor hybrid histidine kinases, similar ... |
347-422 |
2.57e-04 |
|
Histidine kinase-like ATPase domain of two-component sensor hybrid histidine kinases, similar to Brucella abortus 2308 CckA; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinase (HKs) similar to Brucella abortus 2308 CckA, which is a component of an essential protein phosphorelay that regulates expression of genes required for growth, division, and intracellular survival; phosphoryl transfer initiates from the sensor kinase CckA and proceeds via the ChpT phosphotransferase to two regulatory substrates: the DNA-binding response regulator CtrA and the phospho-receiver protein CpdR. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), a REC signal receiver domain, and some contain PAS or PAS and GAF sensor domain(s).
Pssm-ID: 340396 [Multi-domain] Cd Length: 116 Bit Score: 40.44 E-value: 2.57e-04
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 489178403 347 LDQGDSCQIRVNDDGPGIPADARQKIFEPFsrlddSRDRSTG-GFGLGLAIVRRVAQWHGGYAEALETPQGGASFRL 422
Cdd:cd16919 42 LIPGNYVCLEVSDTGSGMPAEVLRRAFEPF-----FTTKEVGkGTGLGLSMVYGFVKQSGGHLRIYSEPGVGTTVRI 113
|
|
| HAMP |
COG2770 |
HAMP domain [Signal transduction mechanisms]; |
26-346 |
3.62e-04 |
|
HAMP domain [Signal transduction mechanisms];
Pssm-ID: 442051 [Multi-domain] Cd Length: 631 Bit Score: 42.79 E-value: 3.62e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489178403 26 VIDAFYDSIVENYHRDAVRGQAYSLVEKLAPLDQAGRQRQLEDWRPHYGLELSLTDARQAKLTQEEQALLDKNLLVVRED 105
Cdd:COG2770 104 LLLAALLLLLLLAALALLLLLLLLLAALLALLLALALLALLLGLAAARLLLAALLALAAALALALGAGELLLLADLAAAI 183
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489178403 106 FTEFISRIDAGPQLLDIKLPPEPSLTPLFTVLAYILLGVLVGIALLVWVRPHW-RDLETLRLAAQRFGDGDLSSRTRIFR 184
Cdd:COG2770 184 AALLAALLLLLLGGLLLVVLLEAALAALLLLLLLALLALLLALLLALLLARRItRPLRRLAEAARRIAAGDLDVRIPVSR 263
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489178403 185 RSDIRTLAQHFNQMADRIESLISNQRELTNAVSHELRTPISRLSFELEQLNKQVDAEVRHDLIEDMRADLGELEEMVSEL 264
Cdd:COG2770 264 KDEIGELARAFNRMADSLRESIEEAEEEEELAEAELARLLEALLELLLALLLLLLALLLLAAAALLLELLLLLLLALLLL 343
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489178403 265 LTYARLEHGNVGSHREIVDAASWLDSVVADVALEAEAAGVTCEISACQVEQIRIEPRFMARAVINLLRNAIRHAHSRVEI 344
Cdd:COG2770 344 LLLAADLLLALALAALLLLLALELLLEAELLVLLALEALALEAELAAVLALLAALAAALLLLELALEELVLALLALALLA 423
|
..
gi 489178403 345 AL 346
Cdd:COG2770 424 LA 425
|
|
| glnL |
PRK11073 |
nitrogen regulation protein NR(II); |
315-409 |
8.82e-04 |
|
nitrogen regulation protein NR(II);
Pssm-ID: 182947 [Multi-domain] Cd Length: 348 Bit Score: 41.22 E-value: 8.82e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489178403 315 QIRIEPRFMARAVINLLRNA---IRHAH------SRVEIALLDQGDSC----QIRVNDDGPGIPADARQKIFEPfsrLDD 381
Cdd:PRK11073 230 ELAHDPDQIEQVLLNIVRNAlqaLGPEGgtitlrTRTAFQLTLHGERYrlaaRIDIEDNGPGIPPHLQDTLFYP---MVS 306
|
90 100
....*....|....*....|....*...
gi 489178403 382 SRDrstGGFGLGLAIVRRVAQWHGGYAE 409
Cdd:PRK11073 307 GRE---GGTGLGLSIARNLIDQHSGKIE 331
|
|
| PRK11086 |
PRK11086 |
sensory histidine kinase DcuS; Provisional |
329-398 |
1.02e-03 |
|
sensory histidine kinase DcuS; Provisional
Pssm-ID: 236839 [Multi-domain] Cd Length: 542 Bit Score: 41.44 E-value: 1.02e-03
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 489178403 329 NLLRNAIRHAHS----RVEIALLDQGDSCQIRVNDDGPGIPADARQKIFEP-FSRLDDSRdrstggfGLGLAIVR 398
Cdd:PRK11086 440 NLIENALEAVGGeeggEISVSLHYRNGWLHCEVSDDGPGIAPDEIDAIFDKgYSTKGSNR-------GVGLYLVK 507
|
|
| NarQ |
COG3850 |
Signal transduction histidine kinase NarQ, nitrate/nitrite-specific [Signal transduction ... |
20-426 |
2.65e-03 |
|
Signal transduction histidine kinase NarQ, nitrate/nitrite-specific [Signal transduction mechanisms];
Pssm-ID: 443059 [Multi-domain] Cd Length: 448 Bit Score: 39.87 E-value: 2.65e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489178403 20 IFVVDHVIDAFYDSIVENYHRDAVRGQAYSLVEKLAPLDQAGRQRQLEDWRPHYGLELSLTDARQAKLTQEEQALLDKNL 99
Cdd:COG3850 2 RELLLLALALLRLLLALLALLLLALLLLSLLALLLLLERTLLRLLSLLASAGLLAALLAALLLLLSLGLLALLLALLLLL 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489178403 100 LVVREDFTEFISRIDAGPQLLDIKLPPEPSLTPLFTVLAYILLGVLVGIALLVWVRPHW---RDLETLRLAAQRFGDGDL 176
Cdd:COG3850 82 LLLLLAALLSLLLLLLLLLLLLLLLLLLLLAAAINRKLALLRLLLALLLALLLAYLLRRrivRPLRRLTQAAERIARGDF 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489178403 177 SSRTRIFRRSDIRTLAQHFNQMADRIESLISNQRELTNAVSHELRTPISRLSFELEQLNKQVDAEVRHDLIEDMRADLGE 256
Cdd:COG3850 162 DARVPVSGRDELGTLARAFNRMADELQELYAELEEEEELEAELELLALLDELLLLAALLLLLALLLALLLAALLAALLLL 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489178403 257 LEEMVSELLTYARLEHGNVGSHREIVDAASWLDSVVADVALEAEAAGVTCEISACQVEQIRIEPRFMARAVINLLRNAIR 336
Cdd:COG3850 242 LLLQDALAESELLALNILAGLLELLLALLLLLLASALLLLELELLALLLELVELLALAAAEEALLLLVELAALLLLLLLQ 321
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489178403 337 HAHSRVEIALLDQGDSCQIRVNDDGPGIPADARQKIFEPFSRLDDSRDRSTGGFGLGLAIVRRVAQWHGGYAEALETPQG 416
Cdd:COG3850 322 AIANASLLLIALASVVAALLELASILALQAALEAAAAGAALAAAAAAAGLARALAQAGADAAEALGLLAEASEGAAGQGA 401
|
410
....*....|
gi 489178403 417 GASFRLTWER 426
Cdd:COG3850 402 GLVDVEGGVA 411
|
|
| PRK10618 |
PRK10618 |
phosphotransfer intermediate protein in two-component regulatory system with RcsBC; Provisional |
176-376 |
2.90e-03 |
|
phosphotransfer intermediate protein in two-component regulatory system with RcsBC; Provisional
Pssm-ID: 236726 [Multi-domain] Cd Length: 894 Bit Score: 39.92 E-value: 2.90e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489178403 176 LSSRTRIF--RRSDIRTLAQHFNQMADRI--ESLISNQRELTNaVSHELRTPISRLSFELEQLNKQVDAEVRHDLIEDMR 251
Cdd:PRK10618 414 LAPRTQLFllRDQDREVLVNKKLQQAQREyeKNQQARKAFLQN-IGDELKQPLQSLAQLAAQLRQTSDEEQQQPELDQLA 492
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489178403 252 ADLGELEEMVSELLTYARLEHGNVGSHREIVDAASWLDSVVADVALEAEAAGVT----CEISAcqvEQIRIEPRFMARAV 327
Cdd:PRK10618 493 EQSDVLVRLVDNIQLLNMLETQDWKPEQELFSLQDLIDEVLPEVLPAIKRKGLQllihNHLKA---EQLRIGDRDALRKI 569
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....
gi 489178403 328 INLLRN-AIRHAHS---RVEIALLDQGDSC-QIRVNDDGPGIPADARQKIFEPF 376
Cdd:PRK10618 570 LLLLLNyAITTTAYgkiTLEVDQDESSPDRlTIRILDTGAGVSIKELDNLHFPF 623
|
|
| HATPase_RsbT-like |
cd16934 |
Histidine kinase-like ATPase domain of the anti sigma-B factor Bacillus subtilis serine ... |
292-401 |
3.51e-03 |
|
Histidine kinase-like ATPase domain of the anti sigma-B factor Bacillus subtilis serine/threonine-protein kinase RsbT, and related domains; This family includes the histidine kinase-like ATPase (HATPase) domain of Bacillus subtilis serine/threonine-protein kinase RsbT, a component of the stressosome signaling complex of Bacillus subtilis. The stressosome is formed from multiple copies of three proteins, a sensor protein RsbR, a scaffold protein RsbS, and RsbT, and responds to environmental changes by initiating a protein partner switching cascade. Stress perception increases the phosphorylation of RsbR and RsbS, by RsbT. Subsequent dissociation of RsbT from the stressosome activates the sigma-B cascade, leading to the release of the alternative sigma factor, sigma-B.
Pssm-ID: 340411 [Multi-domain] Cd Length: 117 Bit Score: 37.35 E-value: 3.51e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 489178403 292 VADVALEAEAAGVTCEISAcqVEQIRIeprfmARAVINLLRNAIRHAHS-RVEIALLDQGD--SCQIRVNDDGPGIPaDA 368
Cdd:cd16934 2 VVDARRAARELARRLGLSE--VRQAEI-----ATAVTELARNLLKHAGGgQVLLEVVAEGGrvALEILAVDQGPGIA-DV 73
|
90 100 110
....*....|....*....|....*....|...
gi 489178403 369 RQKIFEPFSrlddsrdrSTGGFGLGLAIVRRVA 401
Cdd:cd16934 74 DEALRDGFS--------TGGGLGLGLGGVRRLA 98
|
|
| |
